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Conserved domains on  [gi|446627176|ref|WP_000704522|]
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MULTISPECIES: alpha/beta hydrolase [Gammaproteobacteria]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
24-286 6.43e-46

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 155.07  E-value: 6.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  24 KHPLIILCHGFCGIR-NVLLpcFANAFTEAGFATITFDYRGFGESDGE-RGRLVPAMQteDIISVINWAEKQECIDNQRI 101
Cdd:COG1073   36 KYPAVVVAHGNGGVKeQRAL--YAQRLAELGFNVLAFDYRGYGESEGEpREEGSPERR--DARAAVDYLRTLPGVDPERI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 102 GLWGTSLGGGHVFSAAAQDQRVKCIVSQLAFADgdvlvtgemneseRASFLSTLNKMAEKKKNTGKEMFVGVTrvlsdde 181
Cdd:COG1073  112 GLLGISLGGGYALNAAATDPRVKAVILDSPFTS-------------LEDLAAQRAKEARGAYLPGVPYLPNVR------- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 182 skvffekikarhpemdikipfLTVMETLQYKPAESAASVQCPVLVVIAGQDSVNPPEQGRALYDAvASGTKELYEEADAC 261
Cdd:COG1073  172 ---------------------LASLLNDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEA-AAEPKELLIVPGAG 229
                        250       260
                 ....*....|....*....|....*
gi 446627176 262 HYDIYEGAfFERVVAVQTQWFKQYL 286
Cdd:COG1073  230 HVDLYDRP-EEEYFDKLAEFFKKNL 253
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
24-286 6.43e-46

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 155.07  E-value: 6.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  24 KHPLIILCHGFCGIR-NVLLpcFANAFTEAGFATITFDYRGFGESDGE-RGRLVPAMQteDIISVINWAEKQECIDNQRI 101
Cdd:COG1073   36 KYPAVVVAHGNGGVKeQRAL--YAQRLAELGFNVLAFDYRGYGESEGEpREEGSPERR--DARAAVDYLRTLPGVDPERI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 102 GLWGTSLGGGHVFSAAAQDQRVKCIVSQLAFADgdvlvtgemneseRASFLSTLNKMAEKKKNTGKEMFVGVTrvlsdde 181
Cdd:COG1073  112 GLLGISLGGGYALNAAATDPRVKAVILDSPFTS-------------LEDLAAQRAKEARGAYLPGVPYLPNVR------- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 182 skvffekikarhpemdikipfLTVMETLQYKPAESAASVQCPVLVVIAGQDSVNPPEQGRALYDAvASGTKELYEEADAC 261
Cdd:COG1073  172 ---------------------LASLLNDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEA-AAEPKELLIVPGAG 229
                        250       260
                 ....*....|....*....|....*
gi 446627176 262 HYDIYEGAfFERVVAVQTQWFKQYL 286
Cdd:COG1073  230 HVDLYDRP-EEEYFDKLAEFFKKNL 253
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
26-269 1.41e-31

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 117.61  E-value: 1.41e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   26 PLIILCHGFCGIRNvLLPCFANAFTEAGFATITFDYRGFGESDGERGRlvPAMQTEDIISVINWAekQECIDNQRIGLWG 105
Cdd:pfam00561   1 PPVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPKAQ--DDYRTDDLAEDLEYI--LEALGLEKVNLVG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  106 TSLGGGHVFSAAAQ-DQRVKCIVSQLAFAdgDVLVTGEMNESERASFLSTLNKMAEKKKNTGKEMFVG--VTRVLSDDES 182
Cdd:pfam00561  76 HSMGGLIALAYAAKyPDRVKALVLLGALD--PPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVAklLALLLLRLRL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  183 KVFFEKIKARHPEMDIKIPFLTVMETLQYKPAESAASVQC-------PVLVVIAGQDSVNPPEQGRALYDAVASgtKELY 255
Cdd:pfam00561 154 LKALPLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKflgrldePTLIIWGDQDPLVPPQALEKLAQLFPN--ARLV 231
                         250
                  ....*....|....
gi 446627176  256 EEADACHYDIYEGA 269
Cdd:pfam00561 232 VIPDAGHFAFLEGP 245
/NonD TIGR00976
putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes ...
49-134 8.87e-05

putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273375 [Multi-domain]  Cd Length: 550  Bit Score: 43.64  E-value: 8.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   49 FTEAGFATITFDYRGFGESDGERGrLVPAMQTEDIISVINWAEKQECIDNqRIGLWGTSLGGGHVFSAAAQDQR-VKCIV 127
Cdd:TIGR00976  49 FVAQGYAVVIQDTRGRGASEGEFD-LLGSDEAADGYDLVDWIAKQPWCDG-NVGMLGVSYLAVTQLLAAVLQPPaLRAIA 126

                  ....*..
gi 446627176  128 SQLAFAD 134
Cdd:TIGR00976 127 PQEGVWD 133
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
16-68 3.07e-03

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 38.71  E-value: 3.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446627176  16 FRVPEGNIKHPLIILCHGFC----GIRNVlLPCFANafteaGFATITFDYRGFGESD 68
Cdd:PLN03084 118 FCVESGSNNNPPVLLIHGFPsqaySYRKV-LPVLSK-----NYHAIAFDWLGFGFSD 168
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
24-286 6.43e-46

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 155.07  E-value: 6.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  24 KHPLIILCHGFCGIR-NVLLpcFANAFTEAGFATITFDYRGFGESDGE-RGRLVPAMQteDIISVINWAEKQECIDNQRI 101
Cdd:COG1073   36 KYPAVVVAHGNGGVKeQRAL--YAQRLAELGFNVLAFDYRGYGESEGEpREEGSPERR--DARAAVDYLRTLPGVDPERI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 102 GLWGTSLGGGHVFSAAAQDQRVKCIVSQLAFADgdvlvtgemneseRASFLSTLNKMAEKKKNTGKEMFVGVTrvlsdde 181
Cdd:COG1073  112 GLLGISLGGGYALNAAATDPRVKAVILDSPFTS-------------LEDLAAQRAKEARGAYLPGVPYLPNVR------- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 182 skvffekikarhpemdikipfLTVMETLQYKPAESAASVQCPVLVVIAGQDSVNPPEQGRALYDAvASGTKELYEEADAC 261
Cdd:COG1073  172 ---------------------LASLLNDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEA-AAEPKELLIVPGAG 229
                        250       260
                 ....*....|....*....|....*
gi 446627176 262 HYDIYEGAfFERVVAVQTQWFKQYL 286
Cdd:COG1073  230 HVDLYDRP-EEEYFDKLAEFFKKNL 253
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
15-286 4.66e-39

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 136.69  E-value: 4.66e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  15 TFRVPEGNIKHPLIILCHGFCGIRNVLLPCFANAFTEAGFATITFDYRGFGESDGERGRLvpamQTEDIISVINWAEKQE 94
Cdd:COG1506   13 WLYLPADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGD----EVDDVLAAIDYLAARP 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  95 CIDNQRIGLWGTSLGGGHVFSAAAQD-QRVKCIVSQLAFADGdvlvtgemneserASFLSTLNKMAEKKKNTGKEMFVGV 173
Cdd:COG1506   89 YVDPDRIGIYGHSYGGYMALLAAARHpDRFKAAVALAGVSDL-------------RSYYGTTREYTERLMGGPWEDPEAY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 174 TRvlsddeskvffekikarhpemdikipfltvmetlqYKPAESAASVQCPVLVVIAGQDSVNPPEQGRALYDAV--ASGT 251
Cdd:COG1506  156 AA-----------------------------------RSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALkkAGKP 200
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446627176 252 KELYEEADACHYDIYEGAffERVVAVQTQWFKQYL 286
Cdd:COG1506  201 VELLVYPGEGHGFSGAGA--PDYLERILDFLDRHL 233
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
26-269 1.41e-31

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 117.61  E-value: 1.41e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   26 PLIILCHGFCGIRNvLLPCFANAFTEAGFATITFDYRGFGESDGERGRlvPAMQTEDIISVINWAekQECIDNQRIGLWG 105
Cdd:pfam00561   1 PPVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPKAQ--DDYRTDDLAEDLEYI--LEALGLEKVNLVG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  106 TSLGGGHVFSAAAQ-DQRVKCIVSQLAFAdgDVLVTGEMNESERASFLSTLNKMAEKKKNTGKEMFVG--VTRVLSDDES 182
Cdd:pfam00561  76 HSMGGLIALAYAAKyPDRVKALVLLGALD--PPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVAklLALLLLRLRL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  183 KVFFEKIKARHPEMDIKIPFLTVMETLQYKPAESAASVQC-------PVLVVIAGQDSVNPPEQGRALYDAVASgtKELY 255
Cdd:pfam00561 154 LKALPLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKflgrldePTLIIWGDQDPLVPPQALEKLAQLFPN--ARLV 231
                         250
                  ....*....|....
gi 446627176  256 EEADACHYDIYEGA 269
Cdd:pfam00561 232 VIPDAGHFAFLEGP 245
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-284 8.38e-23

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 93.53  E-value: 8.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   1 MKITDHKL--SEGIALTFRV--PEGNIKhPLIILCHGFCGIRNVLLPcFANAFTEAGFATITFDYRGFGESDGERGRLV- 75
Cdd:COG2267    1 MTRRLVTLptRDGLRLRGRRwrPAGSPR-GTVVLVHGLGEHSGRYAE-LAEALAAAGYAVLAFDLRGHGRSDGPRGHVDs 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  76 PAMQTEDIISVINWAEKQeciDNQRIGLWGTSLGGGHVFSAAAQ-DQRVKCIVsqlafadgdvlvtgemneserasFLST 154
Cdd:COG2267   79 FDDYVDDLRAALDALRAR---PGLPVVLLGHSMGGLIALLYAARyPDRVAGLV-----------------------LLAP 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 155 LNkmaekkkntgkemfvgvtrvlsddeskvffekikARHPEMDIKIPFLTVMEtlqykPAESAASVQCPVLVVIAGQDSV 234
Cdd:COG2267  133 AY----------------------------------RADPLLGPSARWLRALR-----LAEALARIDVPVLVLHGGADRV 173
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 446627176 235 NPPEQGRALYDAVASGtKELYEEADACHyDIYEGAFFERVVAVQTQWFKQ 284
Cdd:COG2267  174 VPPEAARRLAARLSPD-VELVLLPGARH-ELLNEPAREEVLAAILAWLER 221
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
27-272 1.47e-18

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 82.26  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   27 LIILCHGFCGIRNVLLPcFANAFTEAGFATITFDYRGFGESDGERGRlVPAMQT--EDIISVINWAEKQECidNQRIGLW 104
Cdd:pfam12146   6 VVVLVHGLGEHSGRYAH-LADALAAQGFAVYAYDHRGHGRSDGKRGH-VPSFDDyvDDLDTFVDKIREEHP--GLPLFLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  105 GTSLGGGHVFSAAAQD-QRVKCIV-SQLAFADGDVLVTGEMneserASFLSTLNKMAEKKKNTGKEMFVGVTRvlsdDES 182
Cdd:pfam12146  82 GHSMGGLIAALYALRYpDKVDGLIlSAPALKIKPYLAPPIL-----KLLAKLLGKLFPRLRVPNNLLPDSLSR----DPE 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  183 KVffeKIKARHPEMDIKIP------FLTVMETLQykpaESAASVQCPVLVVIAGQDSVNPPEQGRALYDAVASGTKELYe 256
Cdd:pfam12146 153 VV---AAYAADPLVHGGISartlyeLLDAGERLL----RRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLK- 224
                         250
                  ....*....|....*.
gi 446627176  257 eadachydIYEGAFFE 272
Cdd:pfam12146 225 --------LYPGLYHE 232
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
18-272 5.31e-17

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 77.70  E-value: 5.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  18 VPEGNIKHPLIILCHGFCG----IRNVllpcfANAFTEAGFATITFDYRGFGESDGE-------RGRLVPAMQTEDIISV 86
Cdd:COG0412   22 RPAGGGPRPGVVVLHEIFGlnphIRDV-----ARRLAAAGYVVLAPDLYGRGGPGDDpdearalMGALDPELLAADLRAA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  87 INWAEKQECIDNQRIGLWGTSLGGGHVFSAAAQDQRVKCIVSqlafadgdvlvtgemneserasflstlnkmaekkkntg 166
Cdd:COG0412   97 LDWLKAQPEVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVS-------------------------------------- 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 167 kemFVGvtRVLSDDeskvffekikarhpemdikipfltvmetlqykPAESAASVQCPVLVVIAGQDSVNPPEQGRALYDA 246
Cdd:COG0412  139 ---FYG--GLPADD--------------------------------LLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAA 181
                        250       260
                 ....*....|....*....|....*...
gi 446627176 247 V--ASGTKELYEEADACHydiyegAFFE 272
Cdd:COG0412  182 LaaAGVDVELHVYPGAGH------GFTN 203
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
28-276 2.44e-13

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 68.04  E-value: 2.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  28 IILCHGFCGIRNVLLPcFANAFTEAGFATITFDYRGFGESDGERGRLVPAMQTEDIISVINWAeKQECidnQRIGLWGTS 107
Cdd:COG1647   18 VLLLHGFTGSPAEMRP-LAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEIL-KAGY---DKVIVIGLS 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 108 LGGghVFS--AAAQDQRVKCIVSqlafadgdvlvtgeMN-----ESERASFLSTLNKMAEKKKNTGKEMfvgvtrvlsdD 180
Cdd:COG1647   93 MGG--LLAllLAARYPDVAGLVL--------------LSpalkiDDPSAPLLPLLKYLARSLRGIGSDI----------E 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 181 ESKVFFEKIKARHPEMdikipfLTVMETLQYKPAESAASVQCPVLVVIAGQDSVNPPEQGRALYDAVASGTKELY----- 255
Cdd:COG1647  147 DPEVAEYAYDRTPLRA------LAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVwleds 220
                        250       260
                 ....*....|....*....|....*...
gi 446627176 256 -------EEADACHYDIYEgaFFERVVA 276
Cdd:COG1647  221 ghvitldKDREEVAEEILD--FLERLAA 246
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
26-258 7.90e-11

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 60.40  E-value: 7.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  26 PLIILCHGFCGIRNVLLPcFANAFtEAGFATITFDYRGFGESDGERGRLVPAMQTEDIISVINWAEKQECIdnqrigLWG 105
Cdd:COG0596   24 PPVVLLHGLPGSSYEWRP-LIPAL-AAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVV------LVG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 106 TSLGGGHVFSAAAQD-QRVKCIvsqlafadgdvlvtgemneserasflstlnkmaekkkntgkemfvgvtrVLSDDESKV 184
Cdd:COG0596   96 HSMGGMVALELAARHpERVAGL-------------------------------------------------VLVDEVLAA 126
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446627176 185 FFEKIkaRHPEMDIKiPFLTVMETL-QYKPAESAASVQCPVLVVIAGQDSVNPPEQGRALYDAVASGTKELYEEA 258
Cdd:COG0596  127 LAEPL--RRPGLAPE-ALAALLRALaRTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGA 198
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
28-274 4.74e-08

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 52.48  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   28 IILCHGFCGIRNVLLpcfanAFTEAGFATITFDYRGFGESDGERGRLVPAMQTEDIIsvinwaekQECIDNQRIGLWGTS 107
Cdd:pfam12697   1 VVLVHGAGLSAAPLA-----ALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALL--------DELGAARPVVLVGHS 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  108 LGGGHVFSAAAQDQRVKCIVSQLAFADGDVLVTGEMNESERASFLSTLNKMAEkkkntgkemfvgvtrvlsdDESKVFFE 187
Cdd:pfam12697  68 LGGAVALAAAAAALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAE-------------------SLARGFLD 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  188 KIKARHPEMDIKIPFLTVMETLQYKPAESAASVQCPVLvVIAGQDSVNPPEQGRALydaVASGTKELYEEADACHYDIYE 267
Cdd:pfam12697 129 DLPADAEWAAALARLAALLAALALLPLAAWRDLPVPVL-VLAEEDRLVPELAQRLL---AALAGARLVVLPGAGHLPLDD 204

                  ....*..
gi 446627176  268 GAFFERV 274
Cdd:pfam12697 205 PEEVAEA 211
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
49-135 1.83e-07

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 51.19  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   49 FTEAGFATITFDYRGFGESDGERgrlVPAMQTE--DIISVINWAEKQ-ECidNQRIGLWGTSLGGGHVFSAAAQDQ-RVK 124
Cdd:pfam02129  47 FAARGYAVVYQDVRGTGGSEGVF---TVGGPQEaaDGKDVIDWLAGQpWC--NGKVGMTGISYLGTTQLAAAATGPpGLK 121
                          90
                  ....*....|.
gi 446627176  125 CIVSQLAFADG 135
Cdd:pfam02129 122 AIAPESGISDL 132
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
49-134 2.56e-07

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 50.31  E-value: 2.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   49 FTEAGFATITFDYRG---FGESDGERGRLVPAMQT-EDIISVINWAEKQECIDNQRIGLWGTSLGGGHVFSAAAQDQRV- 123
Cdd:pfam00326  10 LADRGYVVAIANGRGsggYGEAFHDAGKGDLGQNEfDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGAALNQRPDLf 89
                          90
                  ....*....|.
gi 446627176  124 KCIVSQLAFAD 134
Cdd:pfam00326  90 KAAVAHVPVVD 100
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
45-127 2.65e-07

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 50.65  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  45 FANAFTEAGFATITFDYRGFGESDGERGRLVPA-MQ---TEDIISVINWAekQECIDNQRIGLWGTSLgGGHVFSAAAQD 120
Cdd:COG4757   51 FARYLAERGFAVLTYDYRGIGLSRPGSLRGFDAgYRdwgELDLPAVLDAL--RARFPGLPLLLVGHSL-GGQLLGLAPNA 127

                 ....*..
gi 446627176 121 QRVKCIV 127
Cdd:COG4757  128 ERVDRLV 134
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
24-286 5.22e-07

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 50.11  E-value: 5.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  24 KHPLIILCHGFCGIRNVLLPcFANAFTEAGFATITFDYRG------FGESDGERGRLVPA---MQTEDIISVINWAEKQE 94
Cdd:COG4188   61 PFPLVVLSHGLGGSREGYAY-LAEHLASHGYVVAAPDHPGsnaadlSAALDGLADALDPEelwERPLDLSFVLDQLLALN 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  95 C--------IDNQRIGLWGTSLGGGHVFSAAAQdqrvkcivsQLAFADGDVLVTGEMNESERASFLSTLNkmaekkkntg 166
Cdd:COG4188  140 KsdpplagrLDLDRIGVIGHSLGGYTALALAGA---------RLDFAALRQYCGKNPDLQCRALDLPRLA---------- 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 167 kemfvgvtRVLSDDEskvffekIKArhpemdiKIPFLTVMETLQykPAESAASVQCPVLVVIAGQDSVNP-PEQGRALYD 245
Cdd:COG4188  201 --------YDLRDPR-------IKA-------VVALAPGGSGLF--GEEGLAAITIPVLLVAGSADDVTPaPDEQIRPFD 256
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176 246 AVASGTKELYEEADACHYDI-------------YEGAFFERVVAVQ------TQWFKQYL 286
Cdd:COG4188  257 LLPGADKYLLTLEGATHFSFldpctpgaailpePDPPGPDRAAIHEylnalsLAFFDAYL 316
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
18-93 1.43e-05

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 44.77  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  18 VPEGNIKhPLIILCH------GFcgIRNVLLPCFANAFTEAGFATITFDYRGFGESDGE--RGRLvpamQTEDIISVINW 89
Cdd:COG2945   17 LPEGPPR-GVALILHphplfgGT--MDNKVVYTLARALVAAGFAVLRFNFRGVGRSEGEfdEGRG----ELDDAAAALDW 89

                 ....
gi 446627176  90 AEKQ 93
Cdd:COG2945   90 LRAQ 93
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
19-112 2.74e-05

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 44.09  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   19 PEGNIKHPLIILCHG----------FCGIRNVLLpcfaNAFTEAGFATITFDYRGFGESdgergrLVPAmQTEDIISVIN 88
Cdd:pfam20434   7 KNAKGPYPVVIWIHGggwnsgdkeaDMGFMTNTV----KALLKAGYAVASINYRLSTDA------KFPA-QIQDVKAAIR 75
                          90       100
                  ....*....|....*....|....*...
gi 446627176   89 W----AEKQEcIDNQRIGLWGTSlGGGH 112
Cdd:pfam20434  76 FlranAAKYG-IDTNKIALMGFS-AGGH 101
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
25-110 3.07e-05

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 44.75  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  25 HPLIILCHGFCG------IRnvllpCFANAFTEAGFATITFDYRGFGesdGERGRLVPAM---QTEDIISVINWAEKQEC 95
Cdd:COG0429   61 KPLVVLLHGLEGssdshyAR-----GLARALYARGWDVVRLNFRGCG---GEPNLLPRLYhsgDTEDLVWVLAHLRARYP 132
                         90
                 ....*....|....*
gi 446627176  96 idNQRIGLWGTSLGG 110
Cdd:COG0429  133 --YAPLYAVGFSLGG 145
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
16-133 4.49e-05

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 43.32  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176  16 FRVPEGNIKHPLIILCHG---FCGIRNVLLPcFANAFTE-AGFATITFDYRgfgesdgergrLVPA----MQTEDIISVI 87
Cdd:COG0657    4 YRPAGAKGPLPVVVYFHGggwVSGSKDTHDP-LARRLAArAGAAVVSVDYR-----------LAPEhpfpAALEDAYAAL 71
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446627176  88 NWAEKQEC---IDNQRIGLWGTSLGGGHVFSAA--AQDQRVKCIVSQLAFA 133
Cdd:COG0657   72 RWLRANAAelgIDPDRIAVAGDSAGGHLAAALAlrARDRGGPRPAAQVLIY 122
/NonD TIGR00976
putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes ...
49-134 8.87e-05

putative hydrolase, CocE/NonD family; This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273375 [Multi-domain]  Cd Length: 550  Bit Score: 43.64  E-value: 8.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   49 FTEAGFATITFDYRGFGESDGERGrLVPAMQTEDIISVINWAEKQECIDNqRIGLWGTSLGGGHVFSAAAQDQR-VKCIV 127
Cdd:TIGR00976  49 FVAQGYAVVIQDTRGRGASEGEFD-LLGSDEAADGYDLVDWIAKQPWCDG-NVGMLGVSYLAVTQLLAAVLQPPaLRAIA 126

                  ....*..
gi 446627176  128 SQLAFAD 134
Cdd:TIGR00976 127 PQEGVWD 133
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
16-118 9.83e-05

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 42.88  E-value: 9.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   16 FRVPEGNIKHPLIILCHGFCGIRNV---LLPCFANAFTEAGFATITFDYRGFGESDGERGRLVPAMQTEDIISVINWAEK 92
Cdd:TIGR03101  16 YHPPVAVGPRGVVIYLPPFAEEMNKsrrMVALQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIE 95
                          90       100
                  ....*....|....*....|....*.
gi 446627176   93 QECidnQRIGLWGTSLGGGHVFSAAA 118
Cdd:TIGR03101  96 QGH---PPVTLWGLRLGALLALDAAN 118
hydr1_PEP TIGR03100
exosortase A system-associated hydrolase 1; This group of proteins are members of the alpha ...
45-127 1.27e-04

exosortase A system-associated hydrolase 1; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 2, TIGR03101) of the same superfamily.


Pssm-ID: 132144  Cd Length: 274  Bit Score: 42.49  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   45 FANAFTEAGFATITFDYRGFGESDGERGRLVPAMqtEDIISVINwAEKQECIDNQRIGLWGTSLGGGHVFSAAAQDQRVK 124
Cdd:TIGR03100  49 LARRLAEAGFPVLRFDYRGMGDSEGENLGFEGID--ADIAAAID-AFREAAPHLRRIVAWGLCDAASAALLYAPADLRVA 125

                  ...
gi 446627176  125 CIV 127
Cdd:TIGR03100 126 GLV 128
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
16-68 3.07e-03

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 38.71  E-value: 3.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446627176  16 FRVPEGNIKHPLIILCHGFC----GIRNVlLPCFANafteaGFATITFDYRGFGESD 68
Cdd:PLN03084 118 FCVESGSNNNPPVLLIHGFPsqaySYRKV-LPVLSK-----NYHAIAFDWLGFGFSD 168
PRK10566 PRK10566
esterase; Provisional
2-128 4.32e-03

esterase; Provisional


Pssm-ID: 182555 [Multi-domain]  Cd Length: 249  Bit Score: 37.66  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446627176   2 KITDHKLSeGIALTFRVPEGNIKHPL--IILCHGFCGIRNVLlPCFANAFTEAGFATITFDYRGFGES-DG-ERGRLV-- 75
Cdd:PRK10566   3 EIETRELA-GIEVLHAFPAGQRDTPLptVFFYHGFTSSKLVY-SYFAVALAQAGFRVIMPDAPMHGARfSGdEARRLNhf 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446627176  76 -PAMQT--EDIISVINWAEKQECIDNQRIGLWGTSLGGGHVFSAAAQDQRVKCIVS 128
Cdd:PRK10566  81 wQILLQnmQEFPTLRAAIREEGWLLDDRLAVGGASMGGMTALGIMARHPWVKCVAS 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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