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Conserved domains on  [gi|446632194|ref|WP_000709540|]
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MULTISPECIES: cysteine hydrolase family protein [Bacillus]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10099067)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 4-154 2.37e-64

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


:

Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 194.73  E-value: 2.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAGMPVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDHPLEKGTDGWRIHAAIAPQEGDNIVEKT 83
Cdd:cd01014    1 ALLVIDVQNGYFDGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGWEIHPELAPLEGETVIEKT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446632194  84 TPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTF----NTEVLRAEDIVKHH 154
Cdd:cd01014   81 VPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFdlpdHGGVLSAEEIHAHY 155
 
Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 4-154 2.37e-64

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 194.73  E-value: 2.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAGMPVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDHPLEKGTDGWRIHAAIAPQEGDNIVEKT 83
Cdd:cd01014    1 ALLVIDVQNGYFDGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGWEIHPELAPLEGETVIEKT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446632194  84 TPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTF----NTEVLRAEDIVKHH 154
Cdd:cd01014   81 VPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFdlpdHGGVLSAEEIHAHY 155
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 4-165 1.12e-51

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 162.77  E-value: 1.12e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAG-MPVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDHP-----------LEKGTDGWRIHAAI 71
Cdd:COG1335    1 ALLVIDVQNDFVPPGaLAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSefaefdlwpphCVPGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  72 APQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTEVLRAediv 151
Cdd:COG1335   81 APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEA---- 156

                        170
                 ....*....|....*
gi 446632194 152 khHNAVL-GAFADVV 165
Cdd:COG1335  157 --ALARLrAAGATVV 169
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 4-158 1.04e-37

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 127.52  E-value: 1.04e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194    4 ALIVIDVQAGMYTAGMP-VHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKD-----------HPLEKGTDGWRIHAAI 71
Cdd:pfam00857   2 ALLVIDMQNDFVDSGGPkVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDdadfalkdrpsPAFPPGTTGAELVPEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   72 APQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTE-VLRAEDI 150
Cdd:pfam00857  82 APLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEaHDAALER 161


                  ....*...
gi 446632194  151 VKHHNAVL 158
Cdd:pfam00857 162 LAQRGAEV 169
PLN02621 PLN02621
nicotinamidase
 2-171 4.36e-25

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 95.62  E-value: 4.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   2 KKALIVIDVQAGMYTAGMPVhnggkfLQTLQELIRECRSNDIPVIYIQHN--GPKDHP-LEKGTDGWRI-----HAAIAP 73
Cdd:PLN02621  20 QAALLVIDMQNYFSSMAEPI------LPALLTTIDLCRRASIPVFFTRHShkSPSDYGmLGEWWDGDLIldgttEAELMP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  74 Q-----EGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTEVlrae 148
Cdd:PLN02621  94 EigrvtGPDEVVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANEEL---- 169

                        170       180
                 ....*....|....*....|....*..
gi 446632194 149 divkhHNAVLG----AFADVVEVKDLK 171
Cdd:PLN02621 170 -----HEATLKnlayGFAYLVDCDRLE 191
 
Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 4-154 2.37e-64

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 194.73  E-value: 2.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAGMPVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDHPLEKGTDGWRIHAAIAPQEGDNIVEKT 83
Cdd:cd01014    1 ALLVIDVQNGYFDGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGWEIHPELAPLEGETVIEKT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446632194  84 TPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTF----NTEVLRAEDIVKHH 154
Cdd:cd01014   81 VPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFdlpdHGGVLSAEEIHAHY 155
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 4-165 1.12e-51

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 162.77  E-value: 1.12e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAG-MPVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDHP-----------LEKGTDGWRIHAAI 71
Cdd:COG1335    1 ALLVIDVQNDFVPPGaLAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSefaefdlwpphCVPGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  72 APQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTEVLRAediv 151
Cdd:COG1335   81 APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAHEA---- 156

                        170
                 ....*....|....*
gi 446632194 152 khHNAVL-GAFADVV 165
Cdd:COG1335  157 --ALARLrAAGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 4-143 7.20e-49

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 155.50  E-value: 7.20e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAG-MPVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDHP----------LEKGTDGWRIHAAIA 72
Cdd:cd00431    1 ALLVVDMQNDFVPGGgLLLPGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPefaellwpphCVKGTEGAELVPELA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446632194  73 PQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTE 143
Cdd:cd00431   81 PLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEE 151
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 4-158 1.04e-37

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 127.52  E-value: 1.04e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194    4 ALIVIDVQAGMYTAGMP-VHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKD-----------HPLEKGTDGWRIHAAI 71
Cdd:pfam00857   2 ALLVIDMQNDFVDSGGPkVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDdadfalkdrpsPAFPPGTTGAELVPEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   72 APQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTE-VLRAEDI 150
Cdd:pfam00857  82 APLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEaHDAALER 161


                  ....*...
gi 446632194  151 VKHHNAVL 158
Cdd:pfam00857 162 LAQRGAEV 169
PLN02621 PLN02621
nicotinamidase
 2-171 4.36e-25

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 95.62  E-value: 4.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   2 KKALIVIDVQAGMYTAGMPVhnggkfLQTLQELIRECRSNDIPVIYIQHN--GPKDHP-LEKGTDGWRI-----HAAIAP 73
Cdd:PLN02621  20 QAALLVIDMQNYFSSMAEPI------LPALLTTIDLCRRASIPVFFTRHShkSPSDYGmLGEWWDGDLIldgttEAELMP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  74 Q-----EGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTEVlrae 148
Cdd:PLN02621  94 EigrvtGPDEVVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANEEL---- 169

                        170       180
                 ....*....|....*....|....*..
gi 446632194 149 divkhHNAVLG----AFADVVEVKDLK 171
Cdd:PLN02621 170 -----HEATLKnlayGFAYLVDCDRLE 191
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
4-170 5.39e-22

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 87.98  E-value: 5.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQA---GMYTAGMPVhnGGKFLQTLQELIRECRSNDIPVIYIQHngPKDHPLE--------------KGTDGWR 66
Cdd:COG1535   21 ALLIHDMQNyflRPYDPDEPP--IRELVANIARLRDACRAAGIPVVYTAQ--PGDQTPEdrgllndfwgpgltAGPEGQE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  67 IHAAIAPQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTEvlr 146
Cdd:COG1535   97 IVDELAPAPGDTVLTKWRYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPFVVADAVADFSRE--- 173

                        170       180
                 ....*....|....*....|....*...
gi 446632194 147 aedivkHHNAVL----GAFADVVEVKDL 170
Cdd:COG1535  174 ------EHRMALeyvaGRCGVVVTTDEV 195
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 4-136 1.80e-17

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 75.52  E-value: 1.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAGMPVHNG-GKFLQTLQELIRECRSNDIPVIY---IQHNGPKDHP-----------LEKGTDGWRIH 68
Cdd:cd01015    1 ALLVIDLVEGYTQPGSYLAPGiAAALENVQRLLAAARAAGVPVIHttvVYDPDGADGGlwarkvpamsdLVEGSPLAAIC 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446632194  69 AAIAPQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDA 136
Cdd:cd01015   81 DELAPQEDEMVLVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVREC 148
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 4-143 1.51e-13

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 64.54  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   4 ALIVIDVQAGMYTAgmpVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDHPLekgtdgwrIHAAIAPQEGDNIVEKT 83
Cdd:cd01012    1 ALLLVDVQEKLAPA---IKSFDELINNTVKLAKAAKLLDVPVILTEQYPKGLGPT--------VPELREVFPDAPVIEKT 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  84 TPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTE 143
Cdd:cd01012   70 SFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKE 129
PRK11440 PRK11440
putative hydrolase; Provisional
 2-143 3.07e-13

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 64.37  E-value: 3.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   2 KKALIVIDVQAGMYT-AGMPvHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKD------HPLEKGTDG-------WRI 67
Cdd:PRK11440   8 TTALVVIDLQEGILPfAGGP-HTADEVVARAARLAAKFRASGSPVVLVRVGWSADyaealkQPVDAPSPAkvlpenwWQH 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446632194  68 HAAIAPQEGDNIVEKTTPDSFHNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTE 143
Cdd:PRK11440  87 PAALGKTDSDIEVTKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACSAASAE 162
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 2-136 6.74e-13

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 63.82  E-value: 6.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   2 KKALIVIDVQAGMYTAG-MPVHNGGKFLQTLQELIRECRSNdiPVIYIQHNGPKDH----------PLE----------- 59
Cdd:cd01011    1 TDALLVVDVQNDFCPGGaLAVPGGDAIVPLINALLSLFQYD--LVVATQDWHPANHasfasnhpgqMPFitlppgpqvlw 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  60 -----KGTDGWRIHAAIAPQEGDNIVEK-TTPDS------FHN-----TNLSEVLQEKGIEHVILSGMQTEYCVDTTTRR 122
Cdd:cd01011   79 pdhcvQGTPGAELHPGLPVPDIDLIVRKgTNPDIdsysafFDNdrrssTGLAEYLRERGIDRVDVVGLATDYCVKATALD 158

                        170
                 ....*....|....
gi 446632194 123 ACSEGYKVTLVSDA 136
Cdd:cd01011  159 ALKAGFEVRVLEDA 172
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
1-135 2.25e-12

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 62.70  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   1 MKKALIVIDVQAGMYTAG-MPVHNGGKFLQTLQELIRECRSNDIPVIYIQHNGPKDH----------PLEKGT-DG---- 64
Cdd:PRK11609   1 MKRALLLVDLQNDFCAGGaLAVPEGDSTIDVANRLIDWCQSRGIPVIASQDWHPANHgsfasnhgaePGTQGElDGlpqt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  65 -WRIH-------AAIAPQEGDN----IVEK-TTP--DS----FHN-----TNLSEVLQEKGIEHVILSGMQTEYCVDTTT 120
Cdd:PRK11609  81 wWPDHcvqnsegAALHPLLNQKaidaVFHKgENPliDSysafFDNghrqkTALDDWLREHGITELIVMGLATDYCVKFTV 160

                        170
                 ....*....|....*
gi 446632194 121 RRACSEGYKVTLVSD 135
Cdd:PRK11609 161 LDALALGYQVNVITD 175
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 2-136 9.76e-12

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 60.85  E-value: 9.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194   2 KKALIVIDVQAGMYTAG-MPVHNGGKFLQTLQElIRECRSNDIPVIY------------IQHNGPKDHPLEK-------- 60
Cdd:PTZ00331  12 NDALIIVDVQNDFCKGGsLAVPDAEEVIPVINQ-VRQSHHFDLVVATqdwhppnhisfaSNHGKPKILPDGTtqglwpph 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  61 ---GTDGWRIHAAIAPQEGDNIVEKTTP---DSF--------HNTNLSEVLQEKGIEHVILSGMQTEYCVDTTTRRACSE 126
Cdd:PTZ00331  91 cvqGTKGAQLHKDLVVERIDIIIRKGTNrdvDSYsafdndkgSKTGLAQILKAHGVRRVFICGLAFDFCVLFTALDAVKL 170

                        170
                 ....*....|
gi 446632194 127 GYKVTLVSDA 136
Cdd:PTZ00331 171 GFKVVVLEDA 180
isochorismatase cd01013
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
 28-143 2.36e-08

Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.


Pssm-ID: 238495  Cd Length: 203  Bit Score: 51.19  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446632194  28 LQTLQELIRECRSNDIPVIYIQHNGPKDhPLEKG--TDGW-----------RIHAAIAPQEGDNIVEKTTPDSFHNTNLS 94
Cdd:cd01013   56 IANIARLRDWCRQAGIPVVYTAQPGNQT-PEQRAllNDFWgpgltaspeetKIVTELAPQPDDTVLTKWRYSAFKRSPLL 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 446632194  95 EVLQEKGIEHVILSGMQTEYCVDTTTRRACSEGYKVTLVSDAHSTFNTE 143
Cdd:cd01013  135 ERLKESGRDQLIITGVYAHIGCLSTAVDAFMRDIQPFVVADAIADFSLE 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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