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Conserved domains on  [gi|446634842|ref|WP_000712188|]
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MULTISPECIES: YvcK family protein [Bacillus]

Protein Classification

gluconeogenesis factor YvcK family protein( domain architecture ID 10785358)

gluconeogenesis factor YvcK family protein similar to gluconeogenesis factor required for morphogenesis under gluconeogenic growth conditions

CATH:  3.40.50.12300
Gene Ontology:  GO:0043743|GO:0051287
SCOP:  4002881

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CofD COG0391
Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family ...
1-315 5.37e-172

Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family [Carbohydrate transport and metabolism, Coenzyme transport and metabolism];


:

Pssm-ID: 440160  Cd Length: 314  Bit Score: 479.25  E-value: 5.37e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   1 MKKERKPKIVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQH 80
Cdd:COG0391    1 RRLARGPKVVAIGGGTGLSTLLRGLKRYTANLTAIVTVADDGGSSGRLRRELGVLPPGDLRNCLAALADDEPLLSRLFQY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  81 RFTTGDGLKGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGKKINR 160
Cdd:COG0391   81 RFSGGGDLAGHSLGNLLLAALTEITGDFVEAIDLLSKLLGVRGRVLPMTLDPVDLVAELEDGRIVRGESAIAKAGGRIER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 161 VFLTPEDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQAL 240
Cdd:COG0391  161 VFLEPEDAPATPEALEAIEEADLIVLGPGSLYTSIIPNLLVPGIAEALRETKAPKVYVCNLMTQPGETDGYSAADHVRAL 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446634842 241 HDHLGQPFINTAIVNNREIPCELRKSYEEEMSTPVVVDEERFVENNIDVIQEGLAKyDDHVVRHDTLKLASILYS 315
Cdd:COG0391  241 ERHLGGPFIDAVLVNNAPVPDELLERYAEEGAEPVELDRERLEELGVRVVRADLLD-EDGPVRHDPEKLARALLE 314
 
Name Accession Description Interval E-value
CofD COG0391
Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family ...
1-315 5.37e-172

Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family [Carbohydrate transport and metabolism, Coenzyme transport and metabolism];


Pssm-ID: 440160  Cd Length: 314  Bit Score: 479.25  E-value: 5.37e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   1 MKKERKPKIVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQH 80
Cdd:COG0391    1 RRLARGPKVVAIGGGTGLSTLLRGLKRYTANLTAIVTVADDGGSSGRLRRELGVLPPGDLRNCLAALADDEPLLSRLFQY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  81 RFTTGDGLKGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGKKINR 160
Cdd:COG0391   81 RFSGGGDLAGHSLGNLLLAALTEITGDFVEAIDLLSKLLGVRGRVLPMTLDPVDLVAELEDGRIVRGESAIAKAGGRIER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 161 VFLTPEDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQAL 240
Cdd:COG0391  161 VFLEPEDAPATPEALEAIEEADLIVLGPGSLYTSIIPNLLVPGIAEALRETKAPKVYVCNLMTQPGETDGYSAADHVRAL 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446634842 241 HDHLGQPFINTAIVNNREIPCELRKSYEEEMSTPVVVDEERFVENNIDVIQEGLAKyDDHVVRHDTLKLASILYS 315
Cdd:COG0391  241 ERHLGGPFIDAVLVNNAPVPDELLERYAEEGAEPVELDRERLEELGVRVVRADLLD-EDGPVRHDPEKLARALLE 314
CofD_related TIGR01826
conserved hypothetical protein, cofD-related; This model represents a subfamily of conserved ...
9-317 1.69e-158

conserved hypothetical protein, cofD-related; This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved]


Pssm-ID: 211689  Cd Length: 310  Bit Score: 444.83  E-value: 1.69e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842    9 IVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQHRFTTGDGL 88
Cdd:TIGR01826   1 VVAIGGGTGLSVLLRGLKELDSRITAIVTVADDGGSSGRLREELDVPPPGDLRNCLAALSDDPSLLSKLFQYRFGGGGEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   89 KGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGKKINRVFLTPEDV 168
Cdd:TIGR01826  81 SGHSLGNLMLAALSEISGSFLEAINLLSKILKVKGRVLPMSEHPVTLVAEFEDGREVRGESNIPKMGGKIDRVRLEPEDV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  169 EPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQALHDHLGQPF 248
Cdd:TIGR01826 161 PALREAVEAIREADLIILGPGSLYTSIIPNLLVPEIAEALRESKAPKVYVCNLMTQPGETDGFSLEDHVDALHRHLGKPF 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446634842  249 INTAIVNNREIPCELRKSYEEEMSTPVVVDEERFVENNIDVIQEGLAKYDDHVVRHDTLKLASILYSLL 317
Cdd:TIGR01826 241 IDTVLVNTEKVPLEVLRNYFEEGSEQVEHDAEGLQKLGIEVIFEDLLRAENGTIRHDPQKLADALERIL 309
CofD pfam01933
2-phospho-L-lactate transferase CofD; This entry contains 2-phospho-L-lactate transferase ...
9-254 1.33e-143

2-phospho-L-lactate transferase CofD; This entry contains 2-phospho-L-lactate transferase (CofD), phosphoenolpyruvate transferase and related sequences. CofD catalyzes the fourth step in the biosynthesis of coenzyme F420, which is the transfer of the 2-phospholactate moiety from lactyl (2)diphospho-(5') guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (F420-0) and GMP. F420 is a flavin derivative found in methanogens, Mycobacteria, and several other lineages. This enzyme is characterized so far in Methanocaldococcus jannaschii (Methanococcus jannaschii) but appears restricted to F420-containing species and is predicted to carry out the same function in these other species. CofD monomer contains 12 beta- strands, seven of them form a Rossmann fold, and 13 alpha-helices.


Pssm-ID: 426519  Cd Length: 249  Bit Score: 404.52  E-value: 1.33e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842    9 IVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQHRFTTGDGL 88
Cdd:pfam01933   1 IVVIGGGTGLSRLLRGLKRYTANLTAIVTVADDGGSSGRLRRELGLLPPGDIRNCLVALADTEPLMEELFQYRFLGDGDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   89 KGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGK---KINRVFLTP 165
Cdd:pfam01933  81 AGHSLGNLFLAALTEITGDFSEAIEALSKVLAVRGRVLPMTDDPVELHAELEDGTIVHGESWIPEARKakpPIKRVFLGP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  166 EDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQALHDHLG 245
Cdd:pfam01933 161 EDAKALPEVLEAIEEADLIVLGPGSLYTSIIPNLLVPGIREALRESKAPKVYVSNIMTQPGETDGYTVSDHAKAIMRHLG 240

                  ....*....
gi 446634842  246 QPFINTAIV 254
Cdd:pfam01933 241 KGYIDAVLV 249
YvcK_like cd07187
family of mostly uncharacterized proteins similar to B.subtilis YvcK; One member of this ...
9-315 1.73e-138

family of mostly uncharacterized proteins similar to B.subtilis YvcK; One member of this protein family, YvcK from Bacillus subtilis, has been proposed to play a role in carbon metabolism, since its function is essential for growth on intermediates of the Krebs cycle and the pentose phosphate pathway. In general, this family of mostly uncharacterized proteins is related to the CofD-like protein family. CofD has been characterized as a 2-phospho-L-lactate transferase involved in F420 biosynthesis. This family appears to have the same conserved phosphate binding site as the other family in this hierarchy, but a different substrate binding site.


Pssm-ID: 132873  Cd Length: 308  Bit Score: 394.24  E-value: 1.73e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   9 IVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEAL-FQHRFTTGDG 87
Cdd:cd07187    1 IVAFGGGTGLSTLLRGLKKYTHNLTAIVTVTDDGGSSGRLRRELGIPAPGDIRNRLVALADDESLAQKLfFLYRRFGDFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  88 LKGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYY--GKKINRVFLTP 165
Cdd:cd07187   81 LRGHSLGNLILAALTLITGSFAEAILLLSRLLGVRGRVLPVTNDPLHLVAELEDGTIVRGESRISHLelGSPIKRVFLEP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 166 EDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQALHDHLG 245
Cdd:cd07187  161 PDPKANPEALEAIEEADLIVYGPGSLYTSILPNLLVKGIAEAIRASKAPKVYICNLMTQPGETDGFTLSDHVRALLRHLG 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 246 QPFINTAIVNNREIPCELRKSYEEEmSTPVVVDEERFVENNIDVIqEGLAKYDDHVVRHDTLKLASILYS 315
Cdd:cd07187  241 EGLLDVVLVNSERPPEEVLRRYEEG-SLPVELDEELLEKLGIRVI-EADLLSEESGIRHDPEKLAAALLE 308
 
Name Accession Description Interval E-value
CofD COG0391
Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family ...
1-315 5.37e-172

Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family [Carbohydrate transport and metabolism, Coenzyme transport and metabolism];


Pssm-ID: 440160  Cd Length: 314  Bit Score: 479.25  E-value: 5.37e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   1 MKKERKPKIVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQH 80
Cdd:COG0391    1 RRLARGPKVVAIGGGTGLSTLLRGLKRYTANLTAIVTVADDGGSSGRLRRELGVLPPGDLRNCLAALADDEPLLSRLFQY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  81 RFTTGDGLKGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGKKINR 160
Cdd:COG0391   81 RFSGGGDLAGHSLGNLLLAALTEITGDFVEAIDLLSKLLGVRGRVLPMTLDPVDLVAELEDGRIVRGESAIAKAGGRIER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 161 VFLTPEDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQAL 240
Cdd:COG0391  161 VFLEPEDAPATPEALEAIEEADLIVLGPGSLYTSIIPNLLVPGIAEALRETKAPKVYVCNLMTQPGETDGYSAADHVRAL 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446634842 241 HDHLGQPFINTAIVNNREIPCELRKSYEEEMSTPVVVDEERFVENNIDVIQEGLAKyDDHVVRHDTLKLASILYS 315
Cdd:COG0391  241 ERHLGGPFIDAVLVNNAPVPDELLERYAEEGAEPVELDRERLEELGVRVVRADLLD-EDGPVRHDPEKLARALLE 314
CofD_related TIGR01826
conserved hypothetical protein, cofD-related; This model represents a subfamily of conserved ...
9-317 1.69e-158

conserved hypothetical protein, cofD-related; This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved]


Pssm-ID: 211689  Cd Length: 310  Bit Score: 444.83  E-value: 1.69e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842    9 IVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQHRFTTGDGL 88
Cdd:TIGR01826   1 VVAIGGGTGLSVLLRGLKELDSRITAIVTVADDGGSSGRLREELDVPPPGDLRNCLAALSDDPSLLSKLFQYRFGGGGEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   89 KGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGKKINRVFLTPEDV 168
Cdd:TIGR01826  81 SGHSLGNLMLAALSEISGSFLEAINLLSKILKVKGRVLPMSEHPVTLVAEFEDGREVRGESNIPKMGGKIDRVRLEPEDV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  169 EPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQALHDHLGQPF 248
Cdd:TIGR01826 161 PALREAVEAIREADLIILGPGSLYTSIIPNLLVPEIAEALRESKAPKVYVCNLMTQPGETDGFSLEDHVDALHRHLGKPF 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446634842  249 INTAIVNNREIPCELRKSYEEEMSTPVVVDEERFVENNIDVIQEGLAKYDDHVVRHDTLKLASILYSLL 317
Cdd:TIGR01826 241 IDTVLVNTEKVPLEVLRNYFEEGSEQVEHDAEGLQKLGIEVIFEDLLRAENGTIRHDPQKLADALERIL 309
CofD pfam01933
2-phospho-L-lactate transferase CofD; This entry contains 2-phospho-L-lactate transferase ...
9-254 1.33e-143

2-phospho-L-lactate transferase CofD; This entry contains 2-phospho-L-lactate transferase (CofD), phosphoenolpyruvate transferase and related sequences. CofD catalyzes the fourth step in the biosynthesis of coenzyme F420, which is the transfer of the 2-phospholactate moiety from lactyl (2)diphospho-(5') guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (F420-0) and GMP. F420 is a flavin derivative found in methanogens, Mycobacteria, and several other lineages. This enzyme is characterized so far in Methanocaldococcus jannaschii (Methanococcus jannaschii) but appears restricted to F420-containing species and is predicted to carry out the same function in these other species. CofD monomer contains 12 beta- strands, seven of them form a Rossmann fold, and 13 alpha-helices.


Pssm-ID: 426519  Cd Length: 249  Bit Score: 404.52  E-value: 1.33e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842    9 IVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQHRFTTGDGL 88
Cdd:pfam01933   1 IVVIGGGTGLSRLLRGLKRYTANLTAIVTVADDGGSSGRLRRELGLLPPGDIRNCLVALADTEPLMEELFQYRFLGDGDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   89 KGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGK---KINRVFLTP 165
Cdd:pfam01933  81 AGHSLGNLFLAALTEITGDFSEAIEALSKVLAVRGRVLPMTDDPVELHAELEDGTIVHGESWIPEARKakpPIKRVFLGP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  166 EDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQALHDHLG 245
Cdd:pfam01933 161 EDAKALPEVLEAIEEADLIVLGPGSLYTSIIPNLLVPGIREALRESKAPKVYVSNIMTQPGETDGYTVSDHAKAIMRHLG 240

                  ....*....
gi 446634842  246 QPFINTAIV 254
Cdd:pfam01933 241 KGYIDAVLV 249
YvcK_like cd07187
family of mostly uncharacterized proteins similar to B.subtilis YvcK; One member of this ...
9-315 1.73e-138

family of mostly uncharacterized proteins similar to B.subtilis YvcK; One member of this protein family, YvcK from Bacillus subtilis, has been proposed to play a role in carbon metabolism, since its function is essential for growth on intermediates of the Krebs cycle and the pentose phosphate pathway. In general, this family of mostly uncharacterized proteins is related to the CofD-like protein family. CofD has been characterized as a 2-phospho-L-lactate transferase involved in F420 biosynthesis. This family appears to have the same conserved phosphate binding site as the other family in this hierarchy, but a different substrate binding site.


Pssm-ID: 132873  Cd Length: 308  Bit Score: 394.24  E-value: 1.73e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   9 IVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEAL-FQHRFTTGDG 87
Cdd:cd07187    1 IVAFGGGTGLSTLLRGLKKYTHNLTAIVTVTDDGGSSGRLRRELGIPAPGDIRNRLVALADDESLAQKLfFLYRRFGDFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  88 LKGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYY--GKKINRVFLTP 165
Cdd:cd07187   81 LRGHSLGNLILAALTLITGSFAEAILLLSRLLGVRGRVLPVTNDPLHLVAELEDGTIVRGESRISHLelGSPIKRVFLEP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 166 EDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQALHDHLG 245
Cdd:cd07187  161 PDPKANPEALEAIEEADLIVYGPGSLYTSILPNLLVKGIAEAIRASKAPKVYICNLMTQPGETDGFTLSDHVRALLRHLG 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 246 QPFINTAIVNNREIPCELRKSYEEEmSTPVVVDEERFVENNIDVIqEGLAKYDDHVVRHDTLKLASILYS 315
Cdd:cd07187  241 EGLLDVVLVNSERPPEEVLRRYEEG-SLPVELDEELLEKLGIRVI-EADLLSEESGIRHDPEKLAAALLE 308
CofD_YvcK cd07044
Family of CofD-like proteins and proteins related to YvcK; CofD is a 2-phospho-L-lactate ...
9-314 5.61e-123

Family of CofD-like proteins and proteins related to YvcK; CofD is a 2-phospho-L-lactate transferase that catalyzes the last step in the biosynthesis of coenzyme F(420)-0 (F(420) without polyglutamate) by transferring the lactyl phosphate moiety of lactyl(2)diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin ribitol (F0). F420 is a hydride carrier, important for energy metabolism of methanogenic archaea, as well as for the biosynthesis of other natural products, like tetracycline in Streptomyces. F420 and some of its precursors are also utilized as cofactors for enzymes, like DNA photolyase in Mycobacterium tuberculosis. YvcK from Bacillus subtilis is a member of a family of mostly uncharacterized proteins and has been proposed to play a role in carbon metabolism, since its function is essential for growth on intermediates of the Krebs cycle and pentose phosphate pathway. Both families appear to have a conserved phosphate binding site, but have different substrate binding residues conserved within each family.


Pssm-ID: 132871  Cd Length: 309  Bit Score: 354.97  E-value: 5.61e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   9 IVIMGGGTGLSVLLRGLKQYPVDITAVVTIADDGGSSGRLRDELEIPPPGDIRNVLVALSDVEPLVEALFQHRFTTG-DG 87
Cdd:cd07044    1 VVVFGGGTGLPVLLRGLKEFPVEITAIVTVADDGGSSGELRN*QDIPPPGDLRNVLVALSDQEDRLEQLFQYRKEEGiNE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  88 LKGHALGNLLLAGMTSITGDFFHAITETSKVLNVRGRVLPAANQSAVLHAELEDGEIVTGESKIPYYGKKINRVFLTPED 167
Cdd:cd07044   81 GLGHSLGNLAIAG*TSITGDFTDAIVELSKVFNIKGNILPSSDDPVSLHAE*EDGTIVHGESFIPKGEKKIDRVFLTPVD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842 168 -VEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYVCNVMTQAGETMGYTAFDHVQALHDHLGQ 246
Cdd:cd07044  161 eASPSREVLEAIEKADNIVIGPGSLYTSILPNISVPGIREALKKT*AKKVYVSNI*TQPGETDEYTSSDHAEALQRHLGR 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446634842 247 PFINTAIVNNREIPCELRKSYEEEMSTPVVVDEERFVENNIDVIQEGLAKYDDHVVRHDTLKLASILY 314
Cdd:cd07044  241 PFIDVVLVDEEDRSDEV*NSYRFDELVPVEVDFFALKRLGCRVISADFL*EENGGSRHNSKELSEIIV 308
CofD_like cd07186
LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; CofD is a ...
9-218 6.26e-14

LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; CofD is a 2-phospho-L-lactate transferase that catalyzes the last step in the biosynthesis of coenzyme F(420)-0 (F(420) without polyglutamate) by transferring the lactyl phosphate moiety of lactyl(2)diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin ribitol (F0). F420 is a hydride carrier, important for energy metabolism of methanogenic archaea, as well as for the biosynthesis of other natural products, like tetracycline in Streptomyces. F420 and some of its precursors are also utilized as cofactors for enzymes, like DNA photolyase in Mycobacterium tuberculosis.


Pssm-ID: 132872  Cd Length: 303  Bit Score: 71.09  E-value: 6.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842   9 IVIMGGGTGLSVLLRGLKQ--YPVDITAVVTIADDGGSSGrlrdeLEIPPpgDIRNVLVALSDV---------------- 70
Cdd:cd07186    1 IVVLSGGTGGAKLLRGLKRvlDPEELTVVVNTGDDFWLSG-----LYVSP--DLDTVLYTLAGLidretgwgiegdtfnt 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446634842  71 -EPLVEALFQHRFTTGDG-LKGHAL-GNLLLAGM--TSITGDFfhaitetSKVLNVRGRVLPAANQSAVLHAELEDGEIV 145
Cdd:cd07186   74 lEALERLGGEEWFRLGDRdRATHILrTEMLREGKslSEVTAEL-------AERLGIKARILPMSDDRVETRVVTDEGDLH 146
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446634842 146 TGESKIPYYGKKINR--VFLTPEDVEPLHETLAEIKRADLLVFGPGSLYTSILPNLVVNKIGDAVLAAKAKKVYV 218
Cdd:cd07186  147 FQEYWVRRRGEPEVRdvRFVGAEEARPAPEVLEAIEDADLVIIGPSNPVTSIGPILALPGIREALRDKKAPVVAV 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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