|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
288-615 |
1.35e-77 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 251.78 E-value: 1.35e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 288 YIYAMASLQPVDEAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSK 367
Cdd:COG5002 62 LLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSAL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 368 NINVLSNKLHSHigqleeDIEKERKLERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEY--YFQAMEREVDKM 445
Cdd:COG5002 142 LLGLLLLAAVER------DITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERreYLEIILEEAERL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 446 DTLILDMLELAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICS--FEVIANQGRIEQVIVNFITNAIR 523
Cdd:COG5002 216 SRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEdpLLVLGDPDRLEQVLTNLLDNAIK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 524 YTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNILELHDAEYGVKNTE 603
Cdd:COG5002 296 YTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEP 375
|
330
....*....|...
gi 446638062 604 D-GVLFYFYLPKK 615
Cdd:COG5002 376 GkGTTFTITLPLA 388
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
382-616 |
1.62e-67 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 219.78 E-value: 1.62e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 382 QLEEDIEKERKLERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEY--YFQAMEREVDKMDTLILDMLELAKFE 459
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERreLLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 460 SGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNIC--SFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTID 537
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPpeLPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 538 EKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDtaRQRSQGGTGLGLAISKNILELHDAEYGVKNTED-GVLFYFYLPKKA 616
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGgGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
382-614 |
4.07e-60 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 203.60 E-value: 4.07e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 382 QLEEDIEKERKLERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYyFQAMEREVDKMDTLILDMLELAKFESG 461
Cdd:COG0642 95 LLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREY-LETILRSADRLLRLINDLLDLSRLEAG 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 462 TYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICS--FEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEK 539
Cdd:COG0642 174 KLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDdlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREG 253
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446638062 540 DRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRsqGGTGLGLAISKNILELHDAEYGVKNTED-GVLFYFYLPK 614
Cdd:COG0642 254 DRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGkGTTFTVTLPL 327
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
311-594 |
6.77e-36 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 140.54 E-value: 6.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 311 YIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLhshigqleediEKE 390
Cdd:PRK10549 168 LIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTL-----------EKN 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 391 rklERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYyFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSF 470
Cdd:PRK10549 237 ---EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPES-VASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPV 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 471 YIDTVIEDICEHLSVEIEKKELHVHKNIC-SFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENK 549
Cdd:PRK10549 313 DLVPLLEVAGGAFRERFASRGLTLQLSLPdSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADS 392
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 446638062 550 GTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNILELHD 594
Cdd:PRK10549 393 APGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHN 437
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
380-616 |
1.23e-35 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 140.69 E-value: 1.23e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 380 IGQLEEDIEK-ERKLERTRKE---FISGVSHELKTPLSIMKSCISILKDGVAEHKKE---YYFQAMEREVDKMDTLILDM 452
Cdd:COG4251 261 LEELEEELEErTAELERSNEEleqFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEegrEYLERIRDAAERMQALIDDL 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 453 LELAKfeSGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHknICSF-EVIANQGRIEQVIVNFITNAIRYTPNKED- 530
Cdd:COG4251 341 LAYSR--VGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIE--VGPLpTVRGDPTLLRQVFQNLISNAIKYSRPGEPp 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 531 -IIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSqgGTGLGLAISKNILELHDAEYGVKNTED-GVLF 608
Cdd:COG4251 417 rIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGeGATF 494
|
....*...
gi 446638062 609 YFYLPKKA 616
Cdd:COG4251 495 YFTLPKAP 502
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
305-616 |
2.79e-35 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 137.79 E-value: 2.79e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 305 VQDYYIYIIAFVVVLIFLAS----FYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLHSHI 380
Cdd:COG5000 3 LQILFLLLLLLIALLLLLLAlwlaLLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 381 GQLEE--------------------------------------------------------------------------- 385
Cdd:COG5000 83 EELEErrryletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeiel 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 386 -------------------------DIEKERKLERTR--KEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEY----- 433
Cdd:COG5000 163 trdgrrtllvrasplrddgyvivfdDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDredle 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 434 -YFQAMEREVDKMDTLILDMLELAKFEsgtyKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNIC--SFEVIANQGRI 510
Cdd:COG5000 243 rALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDpdLPEVLADRDQL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 511 EQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdTARQRsqgGTGLGLAISKNIL 590
Cdd:COG5000 319 EQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TTKPK---GTGLGLAIVKKIV 392
|
410 420
....*....|....*....|....*..
gi 446638062 591 ELHDAEYGVKNTED-GVLFYFYLPKKA 616
Cdd:COG5000 393 EEHGGTIELESRPGgGTTFTIRLPLAE 419
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
369-613 |
3.90e-32 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 127.61 E-value: 3.90e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 369 INVLSNKLHSHIGQLEEDIEK----ERKLERTRK-----EFISGVSHELKTPLSIMKSCISILKDGVAEHKK----EYYF 435
Cdd:COG4191 105 ENAELEELERDITELERAEEElrelQEQLVQSEKlaalgELAAGIAHEINNPLAAILGNAELLRRRLEDEPDpeelREAL 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 436 QAMEREVDKMDTLILDMLELAKFESGtykmKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICS--FEVIANQGRIEQV 513
Cdd:COG4191 185 ERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNELIDEALELLRPRLKARGIEVELDLPPdlPPVLGDPGQLEQV 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 514 IVNFITNAIRYTPNKED--IIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdTARqRSQGGTGLGLAISKNILE 591
Cdd:COG4191 261 LLNLLINAIDAMEEGEGgrITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF---TTK-PVGKGTGLGLSISYGIVE 336
|
250 260
....*....|....*....|...
gi 446638062 592 LHDAEYGVKNTED-GVLFYFYLP 613
Cdd:COG4191 337 KHGGRIEVESEPGgGTTFTITLP 359
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
335-615 |
4.56e-29 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 120.12 E-value: 4.56e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 335 LLKINDTTKKIAQLDFTEKIPItskdeigdlskninVLSNKLHSHI-------GQL---EEDIEKERKLERTRKEFISGV 404
Cdd:PRK11006 146 LLRYPEFTQYLKTRDFSRPLTL--------------VLNNGRHLEIrvmpyteGQLlmvARDVTQMHQLEGARRNFFANV 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 405 SHELKTPLSIMKSCISILKDGVAEHK-KEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEdICEHL 483
Cdd:PRK11006 212 SHELRTPLTVLQGYLEMMQDQPLEGAlREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLR-VLERE 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 484 SVEIEKKELHVHKNI-CSFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIW 562
Cdd:PRK11006 291 AQTLSQGKHTITFEVdNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLT 370
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 446638062 563 DRFYRVDTARQRSQGGTGLGLAISKNILELHDAEYGVKNTED-GVLFYFYLPKK 615
Cdd:PRK11006 371 ERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGkGTRFSFVLPER 424
|
|
| his_kin_PieS |
NF041210 |
two component system sensor histidine kinase PieS; |
308-613 |
7.68e-29 |
|
two component system sensor histidine kinase PieS;
Pssm-ID: 469114 [Multi-domain] Cd Length: 474 Bit Score: 120.28 E-value: 7.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 308 YYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLHSHigqlEEDI 387
Cdd:NF041210 168 YMFYTILLSITIALILSAILSKLQVNRINKLRKATKRVIRGNYETRLKENNFDEIGALAHDFNKMTETLAES----KEEI 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 388 EKErklERTRKEFISGVSHELKTPLSImkscISILKDG-----VAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGT 462
Cdd:NF041210 244 ERQ---EKRRRQFIADVSHEMRTPLTT----ISGLTEGlvndiIPKSETDRCIALIDTEAKRLTKLVNENLDYERIRSNK 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 463 YKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNI-CSFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDR 541
Cdd:NF041210 317 IQLYKTRFGVHAFLDLIKEQLEPLASEKGNQIIVDApLDLEVYADYDRLTQIVINIVKNSIQFTENGTITLTGRQDYKET 396
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446638062 542 IkVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQ-GGTGLGLAISKNILELHDAEYGVKNT-EDGVLFYFYLP 613
Cdd:NF041210 397 I-LTITDTGIGMDTGELEQIWERFYKADMSRTSTAfGESGIGLSIVKQLVEYHDGSIEVESEpNKGTTFTIRLP 469
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
281-599 |
1.47e-28 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 119.03 E-value: 1.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 281 EKDGSVTYIYAMASLQPVDEavQMVQDYYIYIIAFVVVLIFLASF---YYSKQIAKPLLKINDTTKKIAQLDFTEKIPIT 357
Cdd:TIGR01386 137 GGKGRKPVQITVALDINAHT--HLLDALRKWLILIAVLLVLLTALlgwWITRLGLEPLRRLSAVAARISPESLDQRLDPS 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 358 SK-DEIGDLSKNINVLsnklhshIGQLEEDIekeRKLERtrkeFISGVSHELKTPLS--IMKSCISILKDGVAEHKKEYY 434
Cdd:TIGR01386 215 RApAELRELAQSFNAM-------LGRLEDAF---QRLSQ----FSADLAHELRTPLTnlLGQTQVALSQPRTGEEYREVL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 435 FQAMErEVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNIcSFEVIANQGRIEQVI 514
Cdd:TIGR01386 281 ESNLE-ELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEG-EGLVRGDPQMFRRAI 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 515 VNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNILELHD 594
Cdd:TIGR01386 359 SNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHG 438
|
....*
gi 446638062 595 AEYGV 599
Cdd:TIGR01386 439 GRASA 443
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
362-616 |
8.45e-28 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 117.18 E-value: 8.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 362 IGDLSKNI-NVLSNKLHSHIGQLEEDIEKER-------KLER-----TRK-EFISGVSHELKTPLS--IMKSCISILKDG 425
Cdd:PRK09835 213 IRSVSRQIqNITSKDLDVRLDPQTVPIELEQlvlsfnhMIERiedvfTRQsNFSADIAHEIRTPITnlITQTEIALSQSR 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 426 VAEHKKEYYFQAMErEVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICSFEVIA 505
Cdd:PRK09835 293 SQKELEDVLYSNLE-ELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAG 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 506 NQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAI 585
Cdd:PRK09835 372 DPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAI 451
|
250 260 270
....*....|....*....|....*....|.
gi 446638062 586 SKNILELHDAEYGVKNTEDGVLFYFYLPKKA 616
Cdd:PRK09835 452 VKSIVVAHKGTVAVTSDARGTRFVISLPRLE 482
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
505-615 |
1.81e-27 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 106.58 E-value: 1.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 505 ANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTaRQRSQGGTGLGLA 584
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 446638062 585 ISKNILELHDAEYGVKNTED-GVLFYFYLPKK 615
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGgGTTFTITLPLE 111
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
385-615 |
7.88e-26 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 111.22 E-value: 7.88e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 385 EDIEKERKLERTRK-----EFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYyFQAMEREVDKMDTLILDMLELAKFE 459
Cdd:COG5809 253 ERKKLEELLRKSEKlsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTY-LDIMLSELDRIESIISEFLVLAKPQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 460 SGTYKMKKdsfyIDTVIEDICEHLSVEIEKKELHVHKNICSFE--VIANQGRIEQVIVNFITNAIRYTPNKEDIIIST-I 536
Cdd:COG5809 332 AIKYEPKD----LNTLIEEVIPLLQPQALLKNVQIELELEDDIpdILGDENQLKQVFINLLKNAIEAMPEGGNITIETkA 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 537 DEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdtarQRSQGGTGLGLAISKNILELHDAEYGVKNTED-GVLFYFYLPKK 615
Cdd:COG5809 408 EDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGkGTTFSITLPIK 481
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
385-613 |
2.49e-25 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 107.62 E-value: 2.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 385 EDIEKERKLERTR---------KEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLEL 455
Cdd:COG3852 114 RDITERKRLERELrraeklaavGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSF 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 456 AKFESgtykMKKDSFYIDTVIEDICEHLSVEIeKKELHVHKNICS--FEVIANQGRIEQVIVNFITNAIRYTPNKEDIII 533
Cdd:COG3852 194 SRPRP----PEREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPslPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITI 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 534 ST----------IDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdTARqrsQGGTGLGLAISKNILELHDAEYGVKNTE 603
Cdd:COG3852 269 RTrverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF---TTK---EKGTGLGLAIVQKIVEQHGGTIEVESEP 342
|
250
....*....|.
gi 446638062 604 D-GVLFYFYLP 613
Cdd:COG3852 343 GkGTTFRIYLP 353
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
406-616 |
6.05e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 108.39 E-value: 6.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 406 HELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDICEHLSV 485
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 486 EIEKKELHVHKNICSFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRF 565
Cdd:PRK11100 345 QAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERF 424
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446638062 566 Y---RVDTARQrsqgGTGLGLAISKNILELHDAEYGVKNTED-GVLFYFYLPKKA 616
Cdd:PRK11100 425 YslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEgGVLATLTLPRHF 475
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
401-593 |
9.75e-24 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 104.63 E-value: 9.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 401 ISGVSHELKTPLSIMKSCISILKDGVAEHKKeyyFQAMEREVDKMDTLILDMLELAKFESGTYkMKKDSFYIDTVIEDIC 480
Cdd:PRK09470 247 LSDISHELRTPLTRLQLATALLRRRQGESKE---LERIETEAQRLDSMINDLLVLSRNQQKNH-LERETFKANSLWSEVL 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 481 EHLSVEIE--KKELHVHKNICSFEVIANQGRIEQVIVNFITNAIRYTpnKEDIIISTIDEKDRIKVCIENKGTHIEEEQL 558
Cdd:PRK09470 323 EDAKFEAEqmGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEEER 400
|
170 180 190
....*....|....*....|....*....|....*
gi 446638062 559 DKIWDRFYRVDTARQRSQGGTGLGLAISKNILELH 593
Cdd:PRK09470 401 EQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
505-615 |
3.67e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 94.36 E-value: 3.67e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 505 ANQGRIEQVIVNFITNAIRYTPNKEDIIIsTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTarqRSQGGTGLGLA 584
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITV-TLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|..
gi 446638062 585 ISKNILELHDAEYGVKNTED-GVLFYFYLPKK 615
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGgGTTVTLTLPLA 108
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
309-616 |
4.12e-23 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 102.30 E-value: 4.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 309 YIYIIAFVVVLiflASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSnklhSHIGQLEEDie 388
Cdd:PRK09467 158 YTLAIGLLSVA---GGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMA----AGIKQLEDD-- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 389 keRKLertrkeFISGVSHELKTPLS-------IMKSCISILKDGvaehkkeyyfqaMEREVDKMDTLI---LDMLELAKf 458
Cdd:PRK09467 229 --RTL------LMAGVSHDLRTPLTrirlateMMSEEDGYLAES------------INKDIEECNAIIeqfIDYLRTGQ- 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 459 esgtyKMKKDSFYIDTVIEDIcehLSVEIE-KKELHVHKNICSFEVIANQGRIEQVIVNFITNAIRYTpnKEDIIISTID 537
Cdd:PRK09467 288 -----EMPMEMADLNALLGEV---IAAESGyEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGT 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 538 EKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSqgGTGLGLAISKNILELHDAEYGVKNTEDGVL-FYFYLPKKA 616
Cdd:PRK09467 358 EGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGLsARAWLPLTT 435
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
510-613 |
4.29e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 91.40 E-value: 4.29e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYTPNKEDII----ISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAI 585
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLrvslEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 446638062 586 SKNILELHDAEYGVKNTED-GVLFYFYLP 613
Cdd:cd16922 81 SKKLVELMGGDISVESEPGqGSTFTFTLP 109
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
385-615 |
9.78e-22 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 98.65 E-value: 9.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 385 EDIEKERKLERT--RKEFIS-------GVSHELKTPLSIMKSCISILKDGVAEHKKeyYFQAMEREVDKMDTLILDMLEL 455
Cdd:COG5805 266 RDITEKKEAEELmaRSEKLSiagqlaaGIAHEIRNPLTSIKGFLQLLQPGIEDKEE--YFDIMLSELDRIESIISEFLAL 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 456 AKFESGTYKMKKdsfyIDTVIEDICEHLSVE--IEKKELHVHKNICSFEVIANQGRIEQVIVNFITNAIRYTPNKEDIII 533
Cdd:COG5805 344 AKPQAVNKEKEN----INELIQDVVTLLETEaiLHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITI 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 534 STIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdTARQRsqgGTGLGLAISKNILELHDAEYGVK-NTEDGVLFYFYL 612
Cdd:COG5805 420 HTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF---TTKEK---GTGLGLMVSYKIIENHNGTIDIDsKVGKGTTFTITL 493
|
...
gi 446638062 613 PKK 615
Cdd:COG5805 494 PLS 496
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
390-613 |
2.33e-21 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 98.12 E-value: 2.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 390 ERKLERTRK-----EFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKfesgTYK 464
Cdd:PRK11360 378 QRRVARQERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRE 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 465 MKKDSFYIDTVIEDicehlsVEIEKKELHvHKNICSFE---------VIANQGRIEQVIVNFITNAIRYTPNKEDIIIST 535
Cdd:PRK11360 454 SQWQPVSLNALVEE------VLQLFQTAG-VQARVDFEteldnelppIWADPELLKQVLLNILINAVQAISARGKIRIRT 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 536 IDEKD-RIKVCIENKGTHIEEEQLDKIWDRFYrvdTARQRsqgGTGLGLAISKNILELHDAEYGVKNTED-GVLFYFYLP 613
Cdd:PRK11360 527 WQYSDgQVAVSIEDNGCGIDPELLKKIFDPFF---TTKAK---GTGLGLALSQRIINAHGGDIEVESEPGvGTTFTLYLP 600
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-614 |
3.51e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 88.54 E-value: 3.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYTPnkEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNI 589
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 446638062 590 LELHDAEYGVKNTE-DGVLFYFYLPK 614
Cdd:cd16949 79 IEQHGGKIKASNRKpGGLRVRIWLPA 104
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
509-593 |
1.29e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 87.13 E-value: 1.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 509 RIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKN 588
Cdd:cd16946 4 RLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHN 83
|
....*
gi 446638062 589 ILELH 593
Cdd:cd16946 84 IALAH 88
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
382-613 |
4.18e-20 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 92.71 E-value: 4.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 382 QLEEDI-----EKERKLERTR-KE-FISGVSHELKTPLSIMKSCISILK----DGVAEHK---KEYYFQAMEREVDKMDT 447
Cdd:PRK09303 129 QLSDELfvlrqENETLLEQLKfKDrVLAMLAHDLRTPLTAASLALETLElgqiDEDTELKpalIEQLQDQARRQLEEIER 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 448 LILDMLELAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICSF--EVIANQGRIEQVIVNFITNAIRYT 525
Cdd:PRK09303 209 LITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDlpSVYADQERIRQVLLNLLDNAIKYT 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 526 PNKEDIIISTIDEKD-RIKVCIENKGTHIEEEQLDKIWDRFYRVDtaRQRSQGGTGLGLAISKNILELHdaeYG----VK 600
Cdd:PRK09303 289 PEGGTITLSMLHRTTqKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVH---YGqiwvDS 363
|
250
....*....|...
gi 446638062 601 NTEDGVLFYFYLP 613
Cdd:PRK09303 364 EPGQGSCFHFTLP 376
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
513-613 |
1.06e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 81.66 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 513 VIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQrsQGGTGLGLAISKNILEL 592
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAIIEL 81
|
90 100
....*....|....*....|.
gi 446638062 593 HDAEYGVKNTEDGVLFYFYLP 613
Cdd:cd16923 82 HGGSASAEYDDNHDLFKVRLP 102
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
514-613 |
2.23e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 78.01 E-value: 2.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 514 IVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNILELH 593
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 446638062 594 DAEYGVKNTE-DGVLFYFYLP 613
Cdd:cd16952 85 DARLLIASELgKGSRFTCLFP 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
379-613 |
2.73e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 85.86 E-value: 2.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 379 HIGQLEED--IEKERklERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDT--LILDMLE 454
Cdd:PRK10490 646 TLTASEEQarLASER--EQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNTtrLVNNLLD 723
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 455 LAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVhkNICSFEVIAN--QGRIEQVIVNFITNAIRYTPNKEDII 532
Cdd:PRK10490 724 MARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINL--SLPEPLTLIHvdGPLFERVLINLLENAVKYAGAQAEIG 801
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 533 ISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDtaRQRSQGGTGLGLAISKNILELHDAEYGVKNT-EDGVLFYFY 611
Cdd:PRK10490 802 IDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRpEGGACFRVT 879
|
..
gi 446638062 612 LP 613
Cdd:PRK10490 880 LP 881
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
284-613 |
6.70e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 83.50 E-value: 6.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 284 GSVTYIYAMASLQPVDEAVqmvqdyyiyiIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIG 363
Cdd:PRK10604 123 GPVPYLYYLHQMRLLDIAL----------LALIGLSLAFPVFLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSSLE 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 364 DLSKNINvlsnklhshigQLEEDIEKerkLERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKkeyyfQAMEREVD 443
Cdd:PRK10604 193 RLGVAFN-----------QMADNINA---LIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAES-----QALNRDIG 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 444 KMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHvhkniCSFEVIANQGR-----IEQVIVNFI 518
Cdd:PRK10604 254 QLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVR-----LDTPHQGDYGAldmrlMERVLDNLL 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 519 TNAIRYTPNKedIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNILELHDAEYG 598
Cdd:PRK10604 329 NNALRYAHSR--VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVN 406
|
330
....*....|....*.
gi 446638062 599 VKNTE-DGVLFYFYLP 613
Cdd:PRK10604 407 CDESElGGARFSFSWP 422
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
382-616 |
2.36e-16 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 81.76 E-value: 2.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 382 QLEEDIEKERKLErTRKEFISGVSHELKTPLSIMKscisilkdGVAEhkkeyYF--------------QAMEREVDKMDT 447
Cdd:PRK10364 223 LLQDEMKRKEKLV-ALGHLAAGVAHEIRNPLSSIK--------GLAK-----YFaerapaggeahqlaQVMAKEADRLNR 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 448 LILDMLELAKFESGTYKmkkdsfyiDTVIEDICEH----LSVEIEKKELHVHKNICSF--EVIANQGRIEQVIVNFITNA 521
Cdd:PRK10364 289 VVSELLELVKPTHLALQ--------AVDLNDLINHslqlVSQDANSREIQLRFTANDTlpEIQADPDRLTQVLLNLYLNA 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 522 IRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvDTARQrsqgGTGLGLAISKNILELHDAEYGVKN 601
Cdd:PRK10364 361 IQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF--TTKAE----GTGLGLAVVHNIVEQHGGTIQVAS 434
|
250
....*....|....*.
gi 446638062 602 TE-DGVLFYFYLPKKA 616
Cdd:PRK10364 435 QEgKGATFTLWLPVNI 450
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
307-593 |
1.09e-15 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 79.50 E-value: 1.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 307 DYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKninvlsnklhshigQLEED 386
Cdd:NF038389 130 YYYIIVFFIFLILLLLILYISVLKSLKPLKKLKKQIKKFANGDFDFIKSESNGDEIGEVAN--------------EFDKA 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 387 IEKERKLERTRKEFISGVSHELKTPlsIMKSCI--SILKDGvaEHKKEyyfqaMEREVDKMDTLILDMLELAKFESGTYK 464
Cdd:NF038389 196 VKKIKALNESRQLFLRNIMHELKTP--ITKGRIvaEMLEDE--KQKER-----LISIFERLESLINEFAKIEQLTSKNYK 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 465 MKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICSFEV------IAnqgrieqvIVNFITNAIRYTPNKEDIIIStidE 538
Cdd:NF038389 267 LNKKEYRLSDIIDEAIDMLMIDDSSVIIKVSLEDFKLNVdfelfsLA--------IKNLIDNAIKYSPDKKVTIEI---K 335
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446638062 539 KDRIkvCIENKGTHIEEEqLDKIWDRFYRvdtARQRSQGGTGLGLAISKNILELH 593
Cdd:NF038389 336 GDKI--EFKNKGEPLEEP-LEYYFEPFFK---GNEKSKSGFGLGLYIVKNILKAH 384
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
301-585 |
1.77e-15 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 79.16 E-value: 1.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 301 AVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLHSHI 380
Cdd:COG3850 112 AAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELY 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 381 GQLEEDIEKERKLERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAkfes 460
Cdd:COG3850 192 AELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLL---- 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 461 gtyKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICSFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKD 540
Cdd:COG3850 268 ---ALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELA 344
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 446638062 541 RIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAI 585
Cdd:COG3850 345 SILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLL 389
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
299-589 |
3.82e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 79.30 E-value: 3.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 299 DEAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLHS 378
Cdd:PRK15347 289 NEALKPALQQLPFALLILVLLTSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKAYNQLLDTLNE 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 379 HIGQLEEDI-EKERKLERTRK----------EFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDT 447
Cdd:PRK15347 369 QYDTLENKVaERTQALAEAKQraeqankrksEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLA 448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 448 LILDMLELAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELhvhknicSFEVIANQG----------RIEQVIVNF 517
Cdd:PRK15347 449 IINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSL-------TLRTFVGAHvplylhldslRLRQILVNL 521
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446638062 518 ITNAIRYTPNKEdIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQrsqgGTGLGLAISKNI 589
Cdd:PRK15347 522 LGNAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ----GTGLGLTIASSL 588
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
298-607 |
5.64e-15 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 78.23 E-value: 5.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 298 VDEAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLH 377
Cdd:COG2770 203 LLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLR 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 378 SHIgqlEEDIEKERKLERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAK 457
Cdd:COG2770 283 ESI---EEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAAL 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 458 FESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNICSFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTID 537
Cdd:COG2770 360 LLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALE 439
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 538 EKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNILELHDAEYGVKNTEDGVL 607
Cdd:COG2770 440 LAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEEL 509
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-605 |
1.52e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 69.80 E-value: 1.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 506 NQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARqRSQGGTGLGLAI 585
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|
gi 446638062 586 SKNILELHDAEYGVKNTEDG 605
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKG 99
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
312-591 |
1.57e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 76.65 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 312 IIAFVVVL---IFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINV----LSNKLHSHIGQLE 384
Cdd:COG4192 329 LAIALLSLllaVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVfrdqAIEKTQELETEIE 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 385 EDIEKERKLERTRKEFI------------SGVSHELKTPLSIMKSCISILKDGVAEHKKE---YYFQAMEREVDKMDTLI 449
Cdd:COG4192 409 ERKRIEKNLRQTQDELIqaakmavvgqtmTSLAHELNQPLNAMSMYLFSAKKALEQENYAqlpTSLDKIEGLIERMDKII 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 450 LDMLELAKFESGTYKmkkdSFYIDTVIEDICEhlSVEIEKKELHVHKNICSF-EVIANQGRIEQVIVNFITNAIRYTPNK 528
Cdd:COG4192 489 KSLRQFSRKSDTPLQ----PVDLRQVIEQAWE--LVESRAKPQQITLHIPDDlMVQGDQVLLEQVLVNLLVNALDAVATQ 562
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446638062 529 EDIIISTIDEKDRIKVCIENKGTHIEEeqLDKIWDRFYrvdtarQRSQGGTGLGLAISKNILE 591
Cdd:COG4192 563 PQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFT------TTKEVGLGLGLSICRSIMQ 617
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
512-605 |
2.93e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 69.36 E-value: 2.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 512 QVIVNFITNAIRYTPNKEDIIIsTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTarqRSQGGTGLGLAISKNILE 591
Cdd:cd16940 16 LLLRNLVDNAVRYSPQGSRVEI-KLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRIVE 91
|
90
....*....|....
gi 446638062 592 LHDAEYGVKNTEDG 605
Cdd:cd16940 92 LHGGQIFLGNAQGG 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
509-613 |
4.66e-14 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 68.67 E-value: 4.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 509 RIEQVIVNFITNAIRYTPNKEDI-IISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISK 587
Cdd:cd16925 4 KYERVVLNLLSNAFKFTPDGGRIrCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVK 83
|
90 100
....*....|....*....|....*..
gi 446638062 588 NILELHDAEYGVKNTE-DGVLFYFYLP 613
Cdd:cd16925 84 EFVELHGGTVTVSDAPgGGALFQVELP 110
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
397-461 |
5.62e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 66.85 E-value: 5.62e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446638062 397 RKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESG 461
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
397-461 |
5.85e-14 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 66.82 E-value: 5.85e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446638062 397 RKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESG 461
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
315-605 |
6.40e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 73.46 E-value: 6.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 315 FVVVLIFLASFYYSKQIAKPLLKIndtTKKIAQ--LDFTEKIPITSK-DEIGDLSKNINVLsnklhshIGQLEEDIEKER 391
Cdd:PRK10755 69 VMVSLTLLICFQAVRWITRPLAEL---QKELEArtADNLTPIAIHSStLEIEAVTSALNQL-------VSRLTSTLDQER 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 392 klertrkEFISGVSHELKTPLSimkscisilkdGVAEH----KKEYYFQAM---EReVDKMDTLILDMLELA----KFES 460
Cdd:PRK10755 139 -------LFTADVAHELRTPLA-----------GIRLHlellEKQHHIDVApliAR-LDQMMHTVEQLLQLAragqSFSS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 461 GTYKMKKdsfYIDTVIEDICEHLSVEIEKKE--LHVHKNICSFEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDE 538
Cdd:PRK10755 200 GHYQTVK---LLEDVILPSQDELSEMLEQRQqtLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQE 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446638062 539 KDRIKVCIENKGTHIEEEQLDKIWDRFYRVDtarQRSqGGTGLGLAISKNILELHDAEYGVKNTEDG 605
Cdd:PRK10755 277 DGGAVLAVEDEGPGIDESKCGELSKAFVRMD---SRY-GGIGLGLSIVSRITQLHHGQFFLQNRQER 339
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
392-613 |
1.01e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 74.56 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 392 KLERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYK--MKKDS 469
Cdd:PRK11466 439 KASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNvsVSDEP 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 470 FYIDTVIEDICEHLSVEIEKKELHVHKNICSFEVIANQG---RIEQVIVNFITNAIRYTpNKEDIIISTIDEKDRIKVCI 546
Cdd:PRK11466 519 FEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPTALMGdprRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEV 597
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446638062 547 ENKGTHIEEEQLDKIWDRFYRVDTARqrsqGGTGLGLAISKNILELHDAEYGVKNT-EDGVLFYFYLP 613
Cdd:PRK11466 598 EDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTpEVGSCFCLRLP 661
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-607 |
6.33e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 65.17 E-value: 6.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVdtAR-QRSQGGTGLGLAISKN 588
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL--PRpHSGQKSTGLGLAFVQE 82
|
90
....*....|....*....
gi 446638062 589 ILELHDAEYGVKNTEDGVL 607
Cdd:cd16945 83 VAQLHGGRITLRNRPDGVL 101
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-613 |
9.27e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 64.73 E-value: 9.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIR----YTPNKEDIIIS-TIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdTARQRsqgGTGLGLA 584
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY---TTKSE---GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 446638062 585 ISKNILELHDAEYGV-KNTEDGVLFYFYLP 613
Cdd:cd16920 75 ICRSIIEAHGGRLSVeSPAGGGATFQFTLP 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
386-591 |
9.30e-13 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 71.69 E-value: 9.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 386 DIEKERKLERT--RKEFISGVSHELKTPLSIMKSCISILK-DGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGT 462
Cdd:PRK09959 699 EVERNKAINATvaKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGN 778
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 463 YKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHkniCS------FEVIANQGRIEQVIVNFITNAIRYTPNKEDIIISTI 536
Cdd:PRK09959 779 YQLQPQWVDIPTLVQNTCHSFGAIAASKSIALS---CSstfpdhYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSL 855
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446638062 537 ----DEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQrsQGGTGLGLAISKNILE 591
Cdd:PRK09959 856 ghidDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQ--QTGSGLGLMICKELIK 912
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
394-457 |
1.08e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 63.00 E-value: 1.08e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446638062 394 ERTRKEFISGVSHELKTPLSIMKSCISILKDGVAEHKK-EYYFQAMEREVDKMDTLILDMLELAK 457
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
512-613 |
1.24e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 64.52 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 512 QVIVNFITNAIRYTPNKE-DIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNIL 590
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 446638062 591 ELHDAEYGVKNTED-----GVLFYFYLP 613
Cdd:cd16953 83 EAHGGISVAENHNQpgqviGARFTVQLP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-607 |
1.59e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.01 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYtpNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTArqRSQGGTGLGLAISKNI 589
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76
|
90
....*....|....*...
gi 446638062 590 LELHDAEYGVKNTEDGVL 607
Cdd:cd16950 77 SDAHGGSLTLANRAGGGL 94
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
384-587 |
1.78e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 70.65 E-value: 1.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 384 EEDIEKERKLE--RTRKEFISGVSHELKTPLSimkSCIS----ILKDGVAEHKKEYyFQAMEREVDKMDTLILDMLELAK 457
Cdd:PRK11107 278 ELDLAKKRAQEaaRIKSEFLANMSHELRTPLN---GVIGftrqTLKTPLTPTQRDY-LQTIERSANNLLAIINDILDFSK 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 458 FESGtyKMKKDS--FYIDTVIEDICEHLSVEIEKKEL----HVHKNICSfEVIANQGRIEQVIVNFITNAIRYTPNKE-D 530
Cdd:PRK11107 354 LEAG--KLVLENipFSLRETLDEVVTLLAHSAHEKGLeltlNIDPDVPD-NVIGDPLRLQQIITNLVGNAIKFTESGNiD 430
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 531 IIISTI---DEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISK 587
Cdd:PRK11107 431 ILVELRalsNTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQ 490
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-613 |
2.11e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 63.50 E-value: 2.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYT---PNKEdIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTarQRSQGGTGLGLAIS 586
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrprRPPR-IEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 446638062 587 KNILELHDAEYGVKNTED-GVLFYFYLP 613
Cdd:cd16921 78 RKIIERHGGRIWLESEPGeGTTFYFTLP 105
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-593 |
2.47e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 63.60 E-value: 2.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdTARQRSQgGTGLGLAISKNI 589
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVGE-GTGLGLSLSYRI 79
|
....
gi 446638062 590 LELH 593
Cdd:cd16943 80 IQKH 83
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-613 |
2.91e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 63.22 E-value: 2.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYTPNKedIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNI 589
Cdd:cd16939 1 MARALDNLLRNALRYAHRT--VRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 446638062 590 LELHDAEYGVKNTE-DGVLFYFYLP 613
Cdd:cd16939 79 ALWHGGHVECDDSElGGACFRLTWP 103
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
236-600 |
5.68e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 68.12 E-value: 5.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 236 GIFLDSIKEFQTNLLLKESKPIQYTTQTMDYEKNDIKYKLLIKPIEKDGSVTYIYAMASLQPVDEAVQMVQDYYIYIIAF 315
Cdd:COG2972 86 LLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 316 VVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTeKIPITSKDEIGDLSKNINVLSNKLHSHIGQLEEDIEKERKLEr 395
Cdd:COG2972 166 LLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAE- 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 396 trkefisgvshelktpLSIMKSCI----------SIlkdgvaehkkeyYFQAMEREVDKMDTLILDMLELAKfesgtYKM 465
Cdd:COG2972 244 ----------------LKALQAQInphflfntlnSI------------RWLAELEDPEEAEEMLEALSKLLR-----YSL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 466 KKDSFYIDTVIE-DICEHLsVEIEK----KELHVHKNICsfEVIANQG---RIEQVIV-NFITNAIRYTPNKEDIIISTI 536
Cdd:COG2972 291 SKGDELVTLEEElELIKSY-LEIQKlrfgDRLEVEIEID--EELLDLLipkLILQPLVeNAIEHGIEPKEGGGTIRISIR 367
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446638062 537 DEKDRIKVCIENKGTHIEEEQLDKIWDRFyrvdtarQRSQGGTGLGLAISKNILELH-DAEYGVK 600
Cdd:COG2972 368 KEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYyGEEYGLE 425
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
505-591 |
1.23e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.15 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 505 ANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLA 584
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLT 95
|
....*..
gi 446638062 585 ISKNILE 591
Cdd:cd16947 96 ITKRLAE 102
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
298-385 |
5.50e-11 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 65.43 E-value: 5.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 298 VDEAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLH 377
Cdd:COG0840 173 ALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLR 252
|
....*...
gi 446638062 378 SHIGQLEE 385
Cdd:COG0840 253 ELVGQVRE 260
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
386-603 |
6.39e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 65.35 E-value: 6.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 386 DIeKERK-----LERTRKE---FISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAK 457
Cdd:PRK11091 265 DI-TERKryqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTIHVSAITLGNIFNDIIDMDK 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 458 FESgtYKMKKDSFYIDTV--IEDIcEHLS-VEIEKKELHVHknicsFE--------VIANQGRIEQVIVNFITNAIRYTP 526
Cdd:PRK11091 344 MER--RKLQLDNQPIDFTdfLADL-ENLSgLQAEQKGLRFD-----LEpllplphkVITDGTRLRQILWNLISNAVKFTQ 415
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446638062 527 NKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRV-DTARQRSQGGTGLGLAISKNILELHDAEYGVKNTE 603
Cdd:PRK11091 416 QGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEE 493
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
333-376 |
1.94e-10 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 56.30 E-value: 1.94e-10
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 446638062 333 KPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKL 376
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
400-594 |
3.66e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 63.07 E-value: 3.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 400 FISGVSHELKTPLSIMKSCISILKDgvaehkkeyyfQAMEREVDKMDT-----------LILDMLELAKFESGTYKMKKD 468
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLLQT-----------KELPKGVDRLVTamnnssslllkIISDILDFSKIESEQLKIEPR 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 469 SFYIDTVIEDICEHLSVEIEKKELHVHkniCSFE----VIANQG--RIEQVIVNFITNAIRYTpnkeD---IIISTIDEK 539
Cdd:PRK10841 519 EFSPREVINHITANYLPLVVKKRLGLY---CFIEpdvpVALNGDpmRLQQVISNLLSNAIKFT----DtgcIVLHVRVDG 591
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446638062 540 DRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQRSQGGTGLGLAISKNILELHD 594
Cdd:PRK10841 592 DYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMD 646
|
|
| HAMP |
pfam00672 |
HAMP domain; |
327-377 |
2.40e-09 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 53.40 E-value: 2.40e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 446638062 327 YSKQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLH 377
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLR 52
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
329-381 |
5.92e-09 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 52.25 E-value: 5.92e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 446638062 329 KQIAKPLLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLHSHIG 381
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
304-596 |
4.77e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 55.79 E-value: 4.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 304 MVQDYYIYIIA----FVVVLIFLASfYYSkqiakpLLKINDTTKKIAQLD--FTEKIPITSKDEIGDLSKNINVLSNKlh 377
Cdd:PRK10815 188 MVWSWFSYVLLanllLVIPLLWLAA-WWS------LRPIEALAKQVRELEegEREQLDPNPPRELTSLVRNLNRLLKN-- 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 378 shigqleediEKER--KLERTrkefISGVSHELKTPLSIMKSCISILKDGvaehKKEYYFQA---MEREVDKMDTLILDM 452
Cdd:PRK10815 259 ----------ERERytKYRTT----LTDLTHSLKTPLAVLQSTLRSLRSG----KQMSVEQAepiMLEQISRISQQIGYY 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 453 LELAKFESGTYKMKKDSFYIDTVIEDICEHLSVEIEKKELHVHKNIcSFEV--IANQGRIEQVIVNFITNAIRYTpnKED 530
Cdd:PRK10815 321 LHRASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDI-SPEItfVGEKNDFMEVMGNVLDNACKYC--LEF 397
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446638062 531 IIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQrsqgGTGLGLAISKNILELHDAE 596
Cdd:PRK10815 398 VEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGK 459
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-605 |
1.47e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 49.76 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYTPNKED--IIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYrvdTARQRSQGgTGLGLAISK 587
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVGKG-TGLGLSISY 76
|
90
....*....|....*...
gi 446638062 588 NILELHDAEYGVKNTEDG 605
Cdd:cd16976 77 GIVEEHGGRLSVANEEGA 94
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-589 |
2.95e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 49.21 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIvnfiTNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQrSQGGTGLGLAISKNI 589
Cdd:cd16948 10 IGQIV----SNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRN-FQESTGMGLYLVKKL 84
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
516-605 |
4.73e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 52.73 E-value: 4.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 516 NFITNAIRYTPNKEDIIIsTIDEkDRIKVciENKGTHIEEEQLDKIWDRFYRvdtARQRSQGGTGLGLAISKNILELHDA 595
Cdd:PRK10337 359 NLLDNAIRYSPQGSVVDV-TLNA-RNFTV--RDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGM 431
|
90
....*....|
gi 446638062 596 EYGVKNTEDG 605
Cdd:PRK10337 432 NVSFGNAPEG 441
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-596 |
1.48e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 48.01 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 506 NQGRIEQVIVNFITNAIRYTpnKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRVDTARQrsqgGTGLGLAI 585
Cdd:cd16954 34 ERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAI 107
|
90
....*....|.
gi 446638062 586 SKNILELHDAE 596
Cdd:cd16954 108 AKEIVEQYGGE 118
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
398-615 |
1.63e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 50.46 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 398 KEFISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLIlDMLeLAKFESGTYKMKKdsfyIDTVIE 477
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYTKVIIEQADRLRNLV-DRL-LGPQRPGTHVTES----IHKVAE 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 478 DICEHLSVEIEKKeLHVHKN----ICSFEVIANQgrIEQVIVNFITNAIR-YTPNKEDIIISTID--------EKDRI-- 542
Cdd:PRK11073 205 RVVQLVSLELPDN-VRLIRDydpsLPELAHDPDQ--IEQVLLNIVRNALQaLGPEGGTITLRTRTafqltlhgERYRLaa 281
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446638062 543 KVCIENKGTHIEEEQLDKIwdrFYRVDTARQrsqGGTGLGLAISKNILELHDAEYGVK----NTEdgvlFYFYLPKK 615
Cdd:PRK11073 282 RIDIEDNGPGIPPHLQDTL---FYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTswpgHTE----FSVYLPIR 348
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
516-615 |
3.14e-06 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 49.85 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 516 NFITNAIRYTPNKED----IIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFYRvdTarqRSQGGTGLGLAISKNILE 591
Cdd:COG3290 288 NLLDNAIEAVEKLPEeerrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS--T---KLGEGRGLGLALVKQIVE 362
|
90 100
....*....|....*....|....*
gi 446638062 592 LHDAEYGVKNTED-GVLFYFYLPKK 615
Cdd:COG3290 363 KYGGTIEVESEEGeGTVFTVRLPKE 387
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
335-613 |
6.80e-06 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 49.29 E-value: 6.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 335 LLKINDTTKKIAQLDFTEKIPITSKDEIGDLSKNINVLSNKLHshIGQLEEDIEK-ERKLERTRK-----EFISGVSHEL 408
Cdd:PRK13837 384 AFKSGDRIVALLGLGRQRYGLRPPAGELQLLELALDCLAHAIE--RRRLETERDAlERRLEHARRleavgTLASGIAHNF 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 409 KTPLSIMKSCISILKDGVAEHKK-EYYFQAMEREVDKMDTLILDMLELAKFESGTYKmkkdSFYIDTVIEDICEHLSVEI 487
Cdd:PRK13837 462 NNILGAILGYAEMALNKLARHSRaARYIDEIISAGARARLIIDQILAFGRKGERNTK----PFDLSELVTEIAPLLRVSL 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 488 -EKKELHVHKNICSFEVIANQGRIEQVIVNFITNAIRY--TPNKEDIIISTID-------------EKDRIKVCIENKGT 551
Cdd:PRK13837 538 pPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAmdGAGRVDISLSRAKlrapkvlshgvlpPGRYVLLRVSDTGA 617
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446638062 552 HIEEEQLDKIWDRFYrvdTARQrsqGGTGLGLAISKNILELHDAEYGVKNTED-GVLFYFYLP 613
Cdd:PRK13837 618 GIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGrGTRFDVYLP 674
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
310-399 |
2.10e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 47.54 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 310 IYIIAFVVVliflasFYYSKQIAKPLLKINDTTKKIAQLDFTE-KIPITSKDEIGDLSKNINVLSNKLHSHIGQLEEDI- 387
Cdd:PRK10935 161 ILTLVFFTV------RFTRRQVVAPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHKLYRSLEASVe 234
|
90
....*....|..
gi 446638062 388 EKERKLERTRKE 399
Cdd:PRK10935 235 EKTRKLTQANRS 246
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-605 |
2.12e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 43.68 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAI-----RYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLDKIWDRFyrVDTarqrSQGGTGLGLA 584
Cdd:cd16944 5 ISQVLTNILKNAAeaiegRPSDVGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPY--VTT----RPKGTGLGLA 78
|
90 100
....*....|....*....|.
gi 446638062 585 ISKNILELHDAEYGVKNTEDG 605
Cdd:cd16944 79 IVKKIMEEHGGRISLSNREAG 99
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
510-613 |
2.07e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 40.85 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446638062 510 IEQVIVNFITNAIRYTPNKE-DIIIST--------IDEKDRI--KVCIENKGTHIEEEQLDKIwdrFYRVDTARQrsqGG 578
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgEIILRTrtqrqvtlGHPRHRLalRVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100 110
....*....|....*....|....*....|....*
gi 446638062 579 TGLGLAISKNILELHDAEYGVKNTEDGVLFYFYLP 613
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| |
