|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
8-393 |
3.08e-142 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 410.27 E-value: 3.08e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 8 QTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGL 87
Cdd:PRK07050 11 QTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 88 SAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGSVTLEFPDLK 165
Cdd:PRK07050 91 AAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADliQPNTRLIWLEAPGSVTMEVPDVP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 166 ALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGIS 245
Cdd:PRK07050 171 AITAAARARGVVTAIDNTYSAGLAFKPF----EH-GVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 246 VSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEIcSTGrSAGLVSVVFKSDYDI 325
Cdd:PRK07050 246 VSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRD-FTG-AGGLFSVVFDERYSP 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446639170 326 SAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTHlqQGLLVRFCIGLEDPQDLIQDIENAL 393
Cdd:PRK07050 324 AQVDAFVEALELFAIGWSWGGACSLAMPYDVASMRTAKWPH--RGTLVRLYIGLEDEADLIADLEQAL 389
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
6-396 |
1.10e-135 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 393.26 E-value: 1.10e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 6 NFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPS 85
Cdd:COG0626 2 GPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 86 GLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGSVTLEFPD 163
Cdd:COG0626 82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAaiRPNTKLVFLETPSNPTLEVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 164 LKALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdeHLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILG 243
Cdd:COG0626 162 IAAIAAIAHAAGALLVVDNTFATPLLQRPL-----ELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 244 ISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICStgRSAGLVSVVFKSDY 323
Cdd:COG0626 237 AVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMS--GFGGMLSFELKGGR 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446639170 324 DisAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTHLQQ----GLLVRFCIGLEDPQDLIQDIENALKQM 396
Cdd:COG0626 315 E--AARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAAlgitDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
25-394 |
1.20e-90 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 277.55 E-value: 1.20e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 25 VQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEV 104
Cdd:cd00614 3 VAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 105 WVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSF--QPSDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDN 182
Cdd:cd00614 83 VASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALeaAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 183 TWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSLAHMS 262
Cdd:cd00614 163 TFATPYLQRPLE-----LGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 263 LRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICStgRSAGLVSVVFKSDYDisAVRRFCDALKLFKLGF 342
Cdd:cd00614 238 LRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMS--GYGGVFSFELKGGLE--AAKKFLNALKLFSLAV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446639170 343 SWGGPVSLVMLydLKMMrklenTHLQ--------QGL---LVRFCIGLEDPQDLIQDIENALK 394
Cdd:cd00614 314 SLGGVESLVEH--PASM-----THSQlppeeraaAGItpgLVRLSVGIEDVEDLIADLEQALK 369
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
8-394 |
5.76e-85 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 263.32 E-value: 5.76e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 8 QTQLIHAPRKAPQFIETVQPPLFRASTIIFKStshlFDRHwtDPYDYSygTHGTPTTFTLGDNIAQIEGGLYCLLAPSGL 87
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFDF----AGEE--GGYDYS--RSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 88 SAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGSVTLEFPDLK 165
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAaiKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 166 ALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGIS 245
Cdd:pfam01053 153 AIAKLAKKHGILVVVDNTFASPYLQRPLD-----LGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 246 VSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICStgRSAGLVSvvFKSDYDI 325
Cdd:pfam01053 228 LSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMK--GFGGMLS--FELKGGL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446639170 326 SAVRRFCDALKLFKLGFSWGGPVSLVmLYDLKM--MRKLENTHLQQGL---LVRFCIGLEDPQDLIQDIENALK 394
Cdd:pfam01053 304 EAAKKFLDNLKLFSLAVSLGGVESLI-SHPATMthASIPPEEREAAGItddLIRLSVGIEDVDDLIADLKQALE 376
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
9-393 |
3.17e-84 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 261.35 E-value: 3.17e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 9 TQLIHAPRKAPQFIETVQPPLFRASTIifkstshLFDRHWTDPYD---YSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPS 85
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTV-------LFDSHAAQRRAkgeLTYGRRGTLTHFALQDAMCELEGGAGCYLYPS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 86 GLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPI---DVSSF-QPSdkTKLLWLEAAGSVTLEF 161
Cdd:TIGR01324 74 GLAAVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLigeDIATLiQPN--TKVLFLEAPSSITFEI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 162 PDLKALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHhRLFRMHAI 241
Cdd:TIGR01324 152 QDIPAIAKAARNPGIVIMIDNTWAAGLLFKPL----EH-GVDISIQAGTKYLVGHSDIMIGTVVANARTWD-QLREHSYL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 242 LGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYW-QEICStgrSAGLVSVVFK 320
Cdd:TIGR01324 226 MGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWkRDFSG---SSGLFSFVLQ 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446639170 321 SDYDiSAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTHLQQGLLVRFCIGLEDPQDLIQDIENAL 393
Cdd:TIGR01324 303 RLTQ-KQVHAFLDHLQLFGLGYSWGGYESLALCNQPELGHRPNIKRNLEGPLIRVHIGLENVDDLKADLKAGF 374
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
9-393 |
9.56e-81 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 253.19 E-value: 9.56e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 9 TQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRhwtdPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLS 88
Cdd:PRK05967 15 TRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAETMATR----GQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 89 AINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNP---IDVSS-FQPSdkTKLLWLEAAGSVTLEFPDL 164
Cdd:PRK05967 91 AVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPeigAGIAKlMRPN--TKVVHTEAPGSNTFEMQDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 165 KALVKKAKAHGVLTALDNTWGAGLAFNAFNFsdehlSVDLTIHALTKYPSGGGDILMGSvVTRDEKLHHRLFRMHAILGI 244
Cdd:PRK05967 169 PAIAEAAHRHGAIVMMDNTWATPLYFRPLDF-----GVDISIHAATKYPSGHSDILLGT-VSANEKCWPQLLEAHGTLGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 245 SVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEicSTGRSAGLVSVVFKSDYD 324
Cdd:PRK05967 243 CAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKR--DFSGASGIFSFVLAAGPE 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446639170 325 ISAVRR--FCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENThlQQGLLVRFCIGLEDPQDLIQDIENAL 393
Cdd:PRK05967 321 KGKAKAhaFLDALEIFGLGYSWGGYESLALHVKLGDRTVAKAP--YAGPVIRLQIGLEDVPDLKADLERGF 389
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
1-396 |
1.66e-69 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 224.23 E-value: 1.66e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKhnnfQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLfdRHWTDPY---DYSYGTHGTPTTFTLGDNIAQIEGG 77
Cdd:PRK09028 3 EKK----ATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEM--RHAAKNRangEMFYGRRGTPTHFAFQAAIVELEGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 78 LYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPI---DVSSF-QPSdkTKLLWLEA 153
Cdd:PRK09028 77 AGTALYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMigeGIRELiRPN--TKVLFLES 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 154 AGSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSvVTRDEKLHH 233
Cdd:PRK09028 155 PGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPF----EM-GVDISIQAATKYIVGHSDVMLGT-ATANEKHWD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 234 RLFRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICSTGRsaG 313
Cdd:PRK09028 229 QLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSN--G 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 314 LVSVVFKSDyDISAVRRFCDALKLFKLGFSWGGPVSLVM-LYDLKMMRKLENTHLqQGLLVRFCIGLEDPQDLIQDIENA 392
Cdd:PRK09028 307 LFSFVLKQG-DPKAVTALVEGMQHFKMGFSWGGFESLILgVFGINKLRTATNWDF-SKPLIRLHIGLEDVDDLIADLEAG 384
|
....
gi 446639170 393 LKQM 396
Cdd:PRK09028 385 FERY 388
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
6-390 |
1.56e-60 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 200.70 E-value: 1.56e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 6 NFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHlfDRHWTDPY---DYSYGTHGTPTTFTLGDNIAQIEGGLYCLL 82
Cdd:PRK08114 5 KLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEA--KKHATRNRangELFYGRRGTLTHFSLQEAMCELEGGAGCAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 83 APSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPID----VSSFQPsdKTKLLWLEAAGSVT 158
Cdd:PRK08114 83 YPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIgadiAKLIQP--NTKVVFLESPGSIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 159 LEFPDLKALVK--KAKAHGVLTALDNTWGAGLAFNAFNFsdehlSVDLTIHALTKYPSGGGDILMGSVVTrDEKLHHRLf 236
Cdd:PRK08114 161 MEVHDVPAIVAavRSVNPDAVIMIDNTWAAGVLFKALDF-----GIDISIQAGTKYLVGHSDAMIGTAVA-NARCWEQL- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 237 RMHAIL-GISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICSTgrSAGLV 315
Cdd:PRK08114 234 RENSYLmGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTG--SSGLF 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446639170 316 SVVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLY---DLKMMRKLENTHLqQGLLVRFCIGLEDPQDLIQDIE 390
Cdd:PRK08114 312 SFVLKKKLTDEQLANYLDNFSLFSMAYSWGGFESLILANqpeEIAAIRPAGEVDF-TGTLIRLHIGLEDVDDLIADLA 388
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
8-395 |
1.52e-48 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 169.09 E-value: 1.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 8 QTQLIHAPRKAPQFiETVQPPLFRASTIIFKSTSHLFDRHwtdpYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGL 87
Cdd:PRK08574 4 GTDAVRGYRGSDPY-GSLQPPIYLTALFRQEGEAYPSDRG----FDLKYSREENPTLRPLEEALAKLEGGVDALAFNSGM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 88 SAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLkDQYGINVQVYNPI--DVSSFQPSDKTKLLWLEAAGSVTLEFPDLK 165
Cdd:PRK08574 79 AAISTLFFSLLKAGDRVVLPMEAYGTTLRLLKSL-EKFGVKVVLAYPSteDIIEAIKEGRTKLVFIETMTNPTLKVIDVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 166 ALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGIS 245
Cdd:PRK08574 158 EVAKAAKELGAILVVDNTFATPLLYRPL----RH-GADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 246 VSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICSTGRSAGLVSVVFKSDYDi 325
Cdd:PRK08574 233 MQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDLYGGVVSFRVKGGRD- 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446639170 326 sAVRRFCDALKLFKLGFSWGGPVSLVMlYDLKMMRKLENTHLQQGL-----LVRFCIGLEDPQDLIQDIENALKQ 395
Cdd:PRK08574 312 -AVLKFLRSLKLIKPSPSLGGVESLAT-YPVKSAASPIPEEDRKALgitedLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
1-396 |
4.19e-48 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 168.03 E-value: 4.19e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIifkstsHLFDRHWTDPYDYSYGthGTPTTFTLGDNIAQIEGGLYC 80
Cdd:PRK08064 1 MAMSYSIDTLLLHNQYKHDKQTGAVNVPIYHASTF------HQFDFDTFGKYDYSRS--GNPTREALEDIIAELEGGTKG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 81 LLAPSGLSAINlvnSA--VLATGDEVWVPDNIYGPNLEHLNYLKDQYGIN---VQVYNPIDVSS-FQPSdkTKLLWLEAA 154
Cdd:PRK08064 73 FAFASGMAAIS---TAflLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEhtfVDMTNLEEVAQnIKPN--TKLFYVETP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 155 GSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHR 234
Cdd:PRK08064 148 SNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLD-----LGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQK 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 235 LFRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEicstgRSAGL 314
Cdd:PRK08064 223 LYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQS-----QATSA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 315 VSVVFKSDYDISAVRRFCDALKLFKLGFSWGGpVSLVMLYDLKM----MRKLEntHLQQGL---LVRFCIGLEDPQDLIQ 387
Cdd:PRK08064 298 GAVLSFTLQSEEAVRQFVSHVKLPVFAVSLGA-VESILSYPAKMshaaMPKEE--RDERGItdgLLRLSVGLENVDDLIA 374
|
....*....
gi 446639170 388 DIENALKQM 396
Cdd:PRK08064 375 DFEQALSYV 383
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
19-395 |
5.52e-46 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 162.17 E-value: 5.52e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 19 PQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINlvnSAVL 98
Cdd:PRK05968 20 GNAFDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAIS---STVL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 99 A---TGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPID---VSSFQPSdkTKLLWLEAAGSVTLEFPDLKALVKKAK 172
Cdd:PRK05968 97 SfvePGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDeeaVAKALPG--AKLLYLESPTSWVFELQDVAALAALAK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 173 AHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGISVSGDDTA 252
Cdd:PRK05968 175 RHGVVTMIDNSWASPVFQRPIT-----LGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYPYLGAKLSPFEAW 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 253 QIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHP--SDKASPGhqywqeicSTGRSaGLVSVVFKSDYDisaVRR 330
Cdd:PRK05968 250 LLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPalANHPPAG--------LSGTS-GLFSFIFREGID---VRA 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446639170 331 FCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTHLQQ-GL---LVRFCIGLEDPQDLIQDIENALKQ 395
Cdd:PRK05968 318 FADALKLFRLGVSWGGHESLVVPAEVVLQQKAQPNSAARfGVsprSVRLHVGLEGTEALWADLEQALAA 386
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
7-396 |
4.14e-44 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 156.98 E-value: 4.14e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 7 FQTQLIHAPRKAPQFIETVQPPLFRASTiiFKSTShlfdrhWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSG 86
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGAVSVPIYQTST--YRQDA------IGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 87 LSAINLVNSaVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQPSDK--TKLLWLEAAGSVTLEFPDL 164
Cdd:PRK06176 75 LAGIHAVFS-LFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKpnTKALYLETPSNPLLKITDL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 165 KALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdeHLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGI 244
Cdd:PRK06176 154 AQCASVAKDHGLLTIVDNTFATPYYQNPL-----LLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 245 SVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICSTgrSAGLVSVVFKSDyd 324
Cdd:PRK06176 229 VLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRG--FSGMLSFTLKND-- 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446639170 325 iSAVRRFCDALKLFKLGFSWGGPVSLV-----MLYDLKMMRKLENTHLQQGlLVRFCIGLEDPQDLIQDIENALKQM 396
Cdd:PRK06176 305 -SEAVAFVESLKLFILGESLGGVESLVgipafMTHACIPKEQREAAGIRDG-LVRLSVGIEHEQDLLEDLEQAFAKI 379
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
7-395 |
8.96e-44 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 156.34 E-value: 8.96e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 7 FQTQLIHAPRKAPQFIETVQPPLFRASTiiFKSTSHLFDRHwtdpyDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSG 86
Cdd:PRK07811 13 FATRAIHAGYEPDPATGAVNPPIYASST--FAQDGVGGLRG-----GYEYARTGNPTRTALEEQLAALEGGAYGRAFSSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 87 LSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINvqvYNPIDVSSFQP-----SDKTKLLWLEAAGSVTLEF 161
Cdd:PRK07811 86 MAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVE---YTPVDLSDLDAvraaiTPRTKLIWVETPTNPLLSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 162 PDLKALVKKAKAHGVLTALDNTWGAG-----LAFNAfnfsdehlsvDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLF 236
Cdd:PRK07811 163 TDIAALAELAHDAGAKVVVDNTFASPylqqpLALGA----------DVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 237 RMHAILGiSVSGD-DTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHqywqEICS--TGRSAG 313
Cdd:PRK07811 233 FLQNGAG-AVPGPfDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGH----EVAArqMRGFGG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 314 LVSVVFKSDYDisAVRRFCDALKLFKLGFSWGGPVSLvMLYDLKMmrklenTH-------LQ-QGLLVRFCIGLEDPQDL 385
Cdd:PRK07811 308 MVSVRLAGGEE--AARDFCARTKVFTLAESLGGVESL-IEHPSAM------THastagsqLEvPDDLVRLSVGIEDVADL 378
|
410
....*....|
gi 446639170 386 IQDIENALKQ 395
Cdd:PRK07811 379 LADLEQALGQ 388
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
25-394 |
3.58e-41 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 149.66 E-value: 3.58e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 25 VQPPLFRASTIIFKStshlfdrhWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEV 104
Cdd:PRK08045 23 VVPPIHLSSTYNFTG--------FNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 105 WVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDN 182
Cdd:PRK08045 95 VAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAalAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 183 TWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSLAHMS 262
Cdd:PRK08045 175 TFLSPALQNPLA-----LGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 263 LRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHqywqEICSTGRSAGLVSVVFKSDYDISAVRRFCDALKLFKLGF 342
Cdd:PRK08045 250 PRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGH----EIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAE 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446639170 343 SWGGPVSLV----------MLYDLKMMRKLENThlqqglLVRFCIGLEDPQDLIQDIENALK 394
Cdd:PRK08045 326 SLGGVESLIshaatmthagMAPEARAAAGISET------LLRISTGIEDGEDLIADLENGFR 381
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
9-395 |
4.45e-40 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 146.51 E-value: 4.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 9 TQLIHAPRKAPQFIETVqPPLFRASTiiFKSTSHLFDrhwtDPYDYSYGthGTPTTFTLGDNIAQIEGGLYCLLAPSGLS 88
Cdd:TIGR01329 3 TLLVNTDNKNDPYDASS-MPIYQTAT--FKQPLAIEN----GPYDYTRS--GNPTRTALESLLAKLDKADRAFAFSSGMA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 89 AINLVnSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQPS--DKTKLLWLEAAGSVTLEFPDLKA 166
Cdd:TIGR01329 74 ALDVI-TRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAAlgPKTKLVLLESPTNPLQKIVDIRK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 167 LVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGISV 246
Cdd:TIGR01329 153 ISEMAHAQNALVVVDNTMMSPLLCNPLE-----LGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 247 SGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQ-YWqeicSTGRSAGLVSVVFKSDYDI 325
Cdd:TIGR01329 228 APFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHlHF----SQAKGAGSVLSFETGSVAL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446639170 326 SavRRFCDALKLFKLGFSWGGPVSLVmlydlKMMRKLENTHLQQGL---------LVRFCIGLEDPQDLIQDIENALKQ 395
Cdd:TIGR01329 304 S--KRLVEATKLFSITVSFGSVNSLI-----SMPCFMSHASIPAEVreerglpedLVRLSVGIEDVDDLISDLDIAFVT 375
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
3-396 |
4.88e-39 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 143.30 E-value: 4.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 3 KHNNFQTQLIHAPRKAPQFIETVQPPlfrastiIFKSTSHlfdRHW----TDPYDYSygTHGTPTTFTLGDNIAQIEGGL 78
Cdd:PRK08247 1 QMSTIETKLAQIGNRSDERTGTVNPP-------VYFSTAY---RHEgigeSTGFDYS--RTGNPTRGVLEQAIADLEGGD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 79 YCLLAPSGLSAINLVNSaVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGS 156
Cdd:PRK08247 69 QGFACSSGMAAIQLVMS-LFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQaiTPNTKAIFIETPTN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 157 VTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLF 236
Cdd:PRK08247 148 PLMQETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLE-----EGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 237 RMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPsdkaspghqywqeicstGRSaGLVS 316
Cdd:PRK08247 223 YYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP-----------------GRG-GMLS 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 317 VVFKsdyDISAVRRFCDALKLFKLGFSWGGPVSLvMLYDLKM--MRKLENTHLQQGL---LVRFCIGLEDPQDLIQDIEN 391
Cdd:PRK08247 285 FRLQ---DEEWVNPFLKSLKLITFAESLGGVESF-ITYPATQthADIPEEIRIANGVcnrLLRFSVGIENVEDLIADLKQ 360
|
....*
gi 446639170 392 ALKQM 396
Cdd:PRK08247 361 AFKQV 365
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
2-396 |
1.28e-38 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 142.67 E-value: 1.28e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 2 KKHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCL 81
Cdd:PRK06767 1 MKKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 82 LAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINvQVYNPIDVSS---FQPSDKTKLLWLEAAGSVT 158
Cdd:PRK06767 81 AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMIT-HSFCDMETEAdieNKIRPNTKLIFVETPINPT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 159 LEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRM 238
Cdd:PRK06767 160 MKLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLE-----LGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPM 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 239 HAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSdkaspghqywQEICS--TGRSAGLVS 316
Cdd:PRK06767 235 RKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE----------GELASrqMKRGGGVIS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 317 VVFKSDYDisAVRRFCDALKLFKLGFSWGGPVSLVMlYDLKMMRKLENTHLQQGL-----LVRFCIGLEDPQDLIQDIEN 391
Cdd:PRK06767 305 FSIKGGKE--ETQAFINDLHFITIAVSLGDTETLIQ-HPATMTHAAIPAELRQEMgiydnLIRLSVGLESWEDIVSDLEQ 381
|
....*
gi 446639170 392 ALKQM 396
Cdd:PRK06767 382 ALKKI 386
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
25-395 |
6.78e-38 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 141.28 E-value: 6.78e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 25 VQPPLFRASTIIFKSTSHlfdrhwtdPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEV 104
Cdd:PRK08776 31 VTPPIVLSSNFSFDGFGN--------KRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNALLQPGDTL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 105 WVPDNIYGPNLEHLNYL--KDQYG-INVQVYNP---IDVSSFQPsdktKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLT 178
Cdd:PRK08776 103 VVPHDAYGGSWRLFNALakKGHFAlITADLTDPrslADALAQSP----KLVLIETPSNPLLRITDLRFVIEAAHKVGALT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 179 ALDNTWGAGLAFNAFNFsdehlSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSL 258
Cdd:PRK08776 179 VVDNTFLSPALQKPLEF-----GADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 259 AHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQywqeICSTGRSAGLVSVVFKSDYDISAVRRFCDALKLF 338
Cdd:PRK08776 254 RTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHA----LAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYF 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446639170 339 KLGFSWGGPVSLV-----MLYDLKMMRKLENTHLQQGLLvRFCIGLEDPQDLIQDIENALKQ 395
Cdd:PRK08776 330 TLAESLGGVESLIahpasMTHAAMTAEARAAAGISDGLL-RLSVGIESAEDLLIDLRAGLAR 390
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-395 |
3.39e-37 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 139.39 E-value: 3.39e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKHN-NFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSH---LFDrhwTDPYDYSYGTHGTPTTFTLGDNIAQIEG 76
Cdd:COG2873 1 MTEKKyGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHaadLFA---LKEPGNIYTRIMNPTTDVLEKRIAALEG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 77 GLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAA 154
Cdd:COG2873 78 GVAALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAaiDPNTKAIFGETI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 155 GSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSVV--------- 225
Cdd:COG2873 158 GNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPI----EH-GADIVVHSATKYIGGHGTSIGGVIVdggnfdwaa 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 226 --------TRDEKLHHRLF-----------RMHAIL----GISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQ 282
Cdd:COG2873 233 ngkfpeltEPDPSYHGLVYteafgnaafitKARVQLlrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAH 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 283 PQFAQVLHPSDKASPGHQYWQEICsTGRSAGLVSVVFKSDYDisAVRRFCDALKLFKLgfswggpvslvmlydlkmmrkL 362
Cdd:COG2873 313 PKVAWVNYPGLPSHPYHELAQKYL-PKGAGGVLTFGLKGGRE--AGKKFIDSLKLFSH---------------------L 368
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 446639170 363 EN--------------THLQ--------QGL---LVRFCIGLEDPQDLIQDIENALKQ 395
Cdd:COG2873 369 ANigdakslvihpastTHSQlseeeqaaAGVtpdLIRLSVGIEDIDDIIADLDQALAA 426
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
3-393 |
8.32e-37 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 138.04 E-value: 8.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 3 KHNNFQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLL 82
Cdd:PRK06234 5 KKMGFATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 83 APSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQPSDK--TKLLWLEAAGSVTLE 160
Cdd:PRK06234 85 AASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKanTKVVYLETPANPTLK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 161 FPDLKALVKKAKAH--GVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHH-RLFR 237
Cdd:PRK06234 165 VTDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQ-----LGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQvKLFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 238 MHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHqywqEICSTGRSAGLVSV 317
Cdd:PRK06234 240 IKDMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYY----ELAKKQMSLPGAMI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 318 VFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLV-----MLYDLKMMRKLENTHLQQGlLVRFCIGLEDPQDLIQDIENA 392
Cdd:PRK06234 316 SFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIqhpasMTHSPYTAEERKEAGISDG-LVRLSVGLEDVDDIIADLKQA 394
|
.
gi 446639170 393 L 393
Cdd:PRK06234 395 L 395
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
25-395 |
2.09e-36 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 136.56 E-value: 2.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 25 VQPPlfrastiIFKSTSHLFDRHWTDPyDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEV 104
Cdd:PRK08861 24 VVPP-------IYLSTNYGFPAFGEVP-KYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 105 WVPDNIYGPNLEHLNYLKDQYGINVQVynpIDVSSFQPSD-----KTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTA 179
Cdd:PRK08861 96 VAPHDCYGGTYRLFNTRANKGDFKVQF---VDQSDAAALDaalakKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 180 LDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSLA 259
Cdd:PRK08861 173 VDNTFLTPVLQKPLE-----LGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 260 HMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHqywqEICSTGRS--AGLVSVVFKSDYDisAVRRFCDALKL 337
Cdd:PRK08861 248 TLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGH----EIAKKQQSgfGSMLSFEFAGSFE--QLKVFVKALAL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446639170 338 FKLGFSWGGPVSLV-----MLYDLKMMRKLENTHLQQGLLvRFCIGLEDPQDLIQDIENALKQ 395
Cdd:PRK08861 322 FSLAESLGGVESLIchpasMTHRAMGEEALAEAGVSQQLL-RLSVGLEDAQDLIADLDQAFAK 383
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
2-395 |
2.10e-36 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 136.86 E-value: 2.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 2 KKHNN--FQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLY 79
Cdd:PRK07503 3 DSHNNtgFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 80 CLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGSV 157
Cdd:PRK07503 83 AVALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAaiSDKTRMVYFETPANP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 158 TLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHH-RLF 236
Cdd:PRK07503 163 NMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLE-----LGADLVVHSATKYLGGHGDITAGLVVGGKALADRiRLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 237 RMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHqywqEICSTGRSAGLVS 316
Cdd:PRK07503 238 GLKDMTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQH----ALAQRQMALPGGM 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 317 VVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLV-----MLYDLKMMRKLENTHLQQGlLVRFCIGLEDPQDLIQDIEN 391
Cdd:PRK07503 314 IAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAqhpasMTHSTYTPEERAEHGISEG-LVRLSVGLEDVADILADLAQ 392
|
....
gi 446639170 392 ALKQ 395
Cdd:PRK07503 393 ALDA 396
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
9-393 |
2.38e-36 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 135.89 E-value: 2.38e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 9 TQLIHAPRKAPQFIETVQPPLfrastiIFKSTSHLFDRHWTDPYdySYGTHGTPTTFTLGDNIAQIEGGlYCLLAPSGLS 88
Cdd:PRK07582 6 TRSVHAGGPEAVPGEPVLPGP------VFAAPYHLSPGEPTGPD--TYGRASNPTWRALEAALGELEGA-EALVFPSGMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 89 AINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVqvynpIDVSSFQP----SDKTKLLWLEAAGSVTLEFPDL 164
Cdd:PRK07582 77 AITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTV-----REAPTAGMaeaaLAGADLVLAETPSNPGLDVCDL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 165 KALVKKAKAHGVLTALDNTwgaglafNAFNFSDEHLSV--DLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLFRMHAIL 242
Cdd:PRK07582 152 AALAAAAHAAGALLVVDNT-------TATPLGQRPLELgaDLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 243 GISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHqywqEICSTG--RSAGLVSVVFK 320
Cdd:PRK07582 225 GAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAH----EVAARQmrRFGGLVSFELA 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446639170 321 sdyDISAVRRFCDALKLFKLGFSWGGpvslvmLYDLKMMRKLENTHLQQGlLVRFCIGLEDPQDLIQDIENAL 393
Cdd:PRK07582 301 ---DAAAAERFVAASRLVVAATSFGG------VHTSADRRARWGDAVPEG-FVRLSCGIEDTDDLVADLERAL 363
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
1-393 |
1.16e-35 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 134.64 E-value: 1.16e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKH--NNFQTQLIHAPR-KAPQFiETVQPPLFRASTIIF-KSTSHLFDRHWTD-PYDYSygTHGTPTTFTLGDNIAQIE 75
Cdd:PRK06434 1 AEKRmlNGFNTRAVQSGElRDPRF-GNVTTPIFETSTFVYpNSEKEAYMDSTRGmPYIYT--RWGNPTVQAFEEKYAVLE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 76 GGLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSS--FQPSDkTKLLWLEA 153
Cdd:PRK06434 78 NAEHALSFSSGMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSldFDPSN-YDLIYAES 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 154 AGSVTLEFPDLKALVKKAKAHGVLtaLDNTWGAglafnAFNFSDEHLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHH 233
Cdd:PRK06434 157 ITNPTLKVPDIKNVSSFCHENDVI--VDATFAS-----PYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 234 RLFRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPghqywQEICSTGrsaG 313
Cdd:PRK06434 230 NLVERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDTEIGK-----KVLRGFG---G 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 314 LVSVVFKSDYDisaVRRFCDALKLFKLGFSWGGPVSLVMLydlkmmrKLENTHL--------QQGL---LVRFCIGLEDP 382
Cdd:PRK06434 302 MLSFELRSMED---VHKFIRNLEIPMVAASLGGVESLITL-------PVETSHSslspeereRLGIsdnLVRFSIGIEDI 371
|
410
....*....|.
gi 446639170 383 QDLIQDIENAL 393
Cdd:PRK06434 372 DDLIKDIENAL 382
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
1-394 |
1.43e-33 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 128.69 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKhnnfQTQLIHAPRKAPQFIETVQPPLFRASTiiFKSTShlFDRHwtdpYDYSYGTHGTPTTFTLGDNIAQIEGGLYC 80
Cdd:PRK07671 1 MRA----KTKLIHGGIIGDPSTGAVSVPIYQVST--YKQEA--VGKH----QGYEYSRTGNPTRAALEELIAVLEGGHAG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 81 LLAPSGLSAINLVNSaVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQPS--DKTKLLWLEAAGSVT 158
Cdd:PRK07671 69 FAFGSGMAAITAVMM-LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAirPNTKAIYVETPTNPL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 159 LEFPDLKALVKKAKAHGVLTALDNT-----WGAGLAFNAfnfsdehlsvDLTIHALTKYPSGGGDILMGSVVTRDEKLHH 233
Cdd:PRK07671 148 LKITDIKKISTIAKEKGLLTIVDNTfmtpyWQSPISLGA----------DIVLHSATKYLGGHSDVVAGLVVVNSPELAE 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 234 RL-FRMHAILGIsVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEIcSTGrSA 312
Cdd:PRK07671 218 DLhFVQNSTGGI-LGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQ-ANG-FG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 313 GLVSvvfksdYDISA---VRRFCDALKLFKLGFSWGGPVSLVMLyDLKMmrklenTH--------LQQGL---LVRFCIG 378
Cdd:PRK07671 295 GMIS------FDVGSeetANKVLERLQYFTLAESLGAVESLISI-PSQM------THasipadrrKELGItdgLIRISVG 361
|
410
....*....|....*.
gi 446639170 379 LEDPQDLIQDIENALK 394
Cdd:PRK07671 362 IEDGEDLIEDLAQALA 377
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
54-393 |
6.66e-32 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 124.47 E-value: 6.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 54 YSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDE-VWVPDNIYGPNLEHLNYLKdQYGINVQVY 132
Cdd:PRK08249 56 HIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYTFLKPGDRvVSIKDTYGGTNKIFTEFLP-RMGVDVTLC 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 133 NPIDVSSFQP--SDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALT 210
Cdd:PRK08249 135 ETGDHEQIEAeiAKGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLA-----LGADLVIHSAT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 211 KYPSGGGDIlMGSVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLH 290
Cdd:PRK08249 210 KFLSGHADA-LGGVVCGSKELMEQVYHYREINGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYY 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 291 PSDKASPGHqywqEICSTGRS--AGLVSVVFKSDYDisAVRRFCDALKLFKLGFSWG------GPVslvmlydlKMMRKL 362
Cdd:PRK08249 289 PGLETHPNH----EIAKAQMRgfGGILSFVLKGGMD--TVKRLLPKLRYAHRAANLGavetiyGPA--------RTTSHV 354
|
330 340 350
....*....|....*....|....*....|....*..
gi 446639170 363 ENT---HLQQGL---LVRFCIGLEDPQDLIQDIENAL 393
Cdd:PRK08249 355 ENTleeRAALGIpegLVRISVGIEDTEDLIADLEQAF 391
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
1-394 |
8.41e-32 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 125.53 E-value: 8.41e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKHNNFQTQLIHAPRKAPQFiETVQPPLFRASTiiFKSTSHLFDrhwtDPYDYSYGthGTPTTFTLGDNIAQIEGGLYC 80
Cdd:PLN02509 81 IKEEASVSTLLVNLDNKFDPF-DAMSTPLYQTAT--FKQPSAIEN----GPYDYTRS--GNPTRDALESLLAKLDKADRA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 81 LLAPSGLSAINLVnSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDV----SSFQPsdKTKLLWLEAAGS 156
Cdd:PLN02509 152 FCFTSGMAALSAV-THLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLdevaAAIGP--QTKLVWLESPTN 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 157 VTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdeHLSVDLTIHALTKYPSGGGDILMGSVVTRDEKLHHRLF 236
Cdd:PLN02509 229 PRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPL-----ELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVY 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 237 RMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQeicSTGRSAGLVS 316
Cdd:PLN02509 304 FLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHF---SQAKGAGSVF 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 317 VVFKSDYDISavRRFCDALKLFKLGFSWGGPVSLVML----------YDLKMMRKLENThlqqglLVRFCIGLEDPQDLI 386
Cdd:PLN02509 381 SFITGSVALS--KHLVETTKYFSIAVSFGSVKSLISMpcfmshasipAEVREARGLTED------LVRISAGIEDVDDLI 452
|
....*...
gi 446639170 387 QDIENALK 394
Cdd:PLN02509 453 SDLDIAFR 460
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
6-394 |
1.30e-31 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 123.57 E-value: 1.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 6 NFQTQLIHAPRKAPQFIETVQPpLFRASTIIFKSTSHLFDR--HWTDPYDYSYGTHGTPTTFTlgDNIAQIEGGLYCLLA 83
Cdd:PRK08133 6 GFDTLAVRAGQLRSPFGEHSEA-LFLTSSFVFESAAEAAARfaGEEPGNIYSRFTNPTVTMFQ--ERLAALEGAEACVAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 84 PSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHL-NYLKdQYGINVQVYNPIDVSSFQPSDK--TKLLWLEAAGSVTLE 160
Cdd:PRK08133 83 ASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFeKIFA-RFGIETTFVDLTDLDAWRAAVRpnTKLFFLETPSNPLTE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 161 FPDLKALVKKAKAHGVLTALDNTWGAG-----LAFNAfnfsdehlsvDLTIHALTKYPSGGGDILMGSVVTRDEKLHhRL 235
Cdd:PRK08133 162 LADIAALAEIAHAAGALLVVDNCFCTPalqqpLKLGA----------DVVIHSATKYLDGQGRVLGGAVVGSKELME-EV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 236 FRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICSTGrsAGLV 315
Cdd:PRK08133 231 FGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGG--GAIV 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 316 SVVFKSDYDisAVRRFCDALKLFKLGFSWGgpvslvmlyDLK--MMRKLENTH------------LQQGlLVRFCIGLED 381
Cdd:PRK08133 309 SFEVKGGRE--AAWRVIDATRLISITANLG---------DTKttITHPATTTHgrlspearaaagITEG-LIRVAVGLED 376
|
410
....*....|...
gi 446639170 382 PQDLIQDIENALK 394
Cdd:PRK08133 377 VADIKADLARGLA 389
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
54-394 |
1.56e-28 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 114.53 E-value: 1.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 54 YSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSaVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYN 133
Cdd:PRK07269 46 FDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAFS-VFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYAN 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 134 PIDVSSFQPSDKTKLLWLEA-AGSVTLEFpDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTKY 212
Cdd:PRK07269 125 TEEELIAAIEEDTDIVYIETpTNPLMVEF-DIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIE-----LGADIVLHSATKY 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 213 PSGGGDILMGSVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPs 292
Cdd:PRK07269 199 LSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 293 dkaspghqywqeicstGRsAGLVSvvFKSdYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKL-ENTHLQQGL 371
Cdd:PRK07269 278 ----------------GK-GGMIS--FKV-ADETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIpAEVRHSYGL 337
|
330 340
....*....|....*....|....*.
gi 446639170 372 ---LVRFCIGLEDPQDLIQDIENALK 394
Cdd:PRK07269 338 tddLLRLSIGIEDARDLIADLKQALE 363
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-393 |
5.23e-28 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 114.04 E-value: 5.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 7 FQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSG 86
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 87 LSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSF--QPSDKTKLLWLEA----AGSVTle 160
Cdd:PRK05994 88 HAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFerAITPRTKAIFIESianpGGTVT-- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 161 fpDLKALVKKAKAHGVLTALDNTwgagLAFNAFNFSDEHlSVDLTIHALTKYPSGGGDILMGSVV-------TRDEK--- 230
Cdd:PRK05994 166 --DIAAIAEVAHRAGLPLIVDNT----LASPYLIRPIEH-GADIVVHSLTKFLGGHGNSMGGIIVdggtfdwSKSGKypm 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 231 ------------LHHRLFRM-HAI---------LGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQV 288
Cdd:PRK05994 239 lseprpeyhglvLHETFGNFaFAIaarvlglrdLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 289 LHPSDKASPGHQYWQEICSTGrsAGLV-SVVFKSDYDisAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLenTHL 367
Cdd:PRK05994 319 NYAGLPDDPYHALAQKYSPKG--AGAVfTFGLKGGYE--AGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQL--TDE 392
|
410 420 430
....*....|....*....|....*....|..
gi 446639170 368 QQGL------LVRFCIGLEDPQDLIQDIENAL 393
Cdd:PRK05994 393 QKVAagagpdVVRLSIGIEDVDDIIADLEQAL 424
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
54-396 |
2.36e-27 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 111.70 E-value: 2.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 54 YSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQyGINVQVYN 133
Cdd:PRK05939 39 FTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSSQFLFGNTNSLFGTLRGL-GVEVTMVD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 134 PIDVS----SFQPSdkTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAfnfsdEHLSVDLTIHAL 209
Cdd:PRK05939 118 ATDVQnvaaAIRPN--TRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSPWLFRP-----KDVGASLVINSL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 210 TKYPSGGGDILMGSVV-------TRDEKLHHRlFRMHAI---------------LGISVSGDDTAQIQRSLAHMSLRYEQ 267
Cdd:PRK05939 191 SKYIAGHGNALGGAVTdtglfdwSAYPNIFPA-YRKGDPqqwgltqirkkglrdMGATLSSEAAHRIAIGAETLALRVDR 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 268 QSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEIcsTGRSAGLVSVVFKSDYDISAvrrFCDALKLF----KLG-- 341
Cdd:PRK05939 270 SCSNALALAQFLEAHPKVARVYYPGLASHPQHARATEL--FRHYGGLLSFELADGIDCFD---FLNRLKLVikatHLGdt 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446639170 342 FSWGGPVSLVMLYDLKMMRKlenthLQQGL---LVRFCIGLEDPQDLIQDIENALKQM 396
Cdd:PRK05939 345 RTLVIPVAPTIYYEMGAERR-----ASMGIadsLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
28-393 |
7.53e-26 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 108.06 E-value: 7.53e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 28 PLFRASTI-IFKSTSHLFD--RHWTDPYDYS-----YGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLA 99
Cdd:PRK06084 16 PTTKAVAVpIYQTTSYAFDdtQHGADLFDLKvpgniYTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITYAIQTIAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 100 TGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVL 177
Cdd:PRK06084 96 AGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEAliDERTKAVFCESIGNPAGNIIDIQALADAAHRHGVP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 178 TALDNTWGAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSVV------------------TRDEKLHHRLFRMH 239
Cdd:PRK06084 176 LIVDNTVATPVLCRPF----EH-GADIVVHSLTKYIGGHGTSIGGIVVdsgkfpwaehkerfallnTPDPSYHGVTYTEA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 240 ---------------AILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQE 304
Cdd:PRK06084 251 fgpaafigrcrvvplRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARR 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 305 ICStGRSAGLVSVVFKSDYDISAvrRFCDALKLFklgfswggpVSLVMLYDLKMM---------RKLENTHLQQ-GL--- 371
Cdd:PRK06084 331 YMG-GKPASILSFGIKGGQAAGA--RFIDALKLV---------VRLVNIGDAKSLachpastthRQLNDEELEKaGVsrd 398
|
410 420
....*....|....*....|..
gi 446639170 372 LVRFCIGLEDPQDLIQDIENAL 393
Cdd:PRK06084 399 MVRLSIGIEHIDDIIADLAQAL 420
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
1-395 |
2.35e-23 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 100.60 E-value: 2.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKHNNFQTQLIHAPRKAPQFIETVQPpLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYC 80
Cdd:PRK07504 5 MARKWRPATRLVHSGTLRSQFGETSEA-LFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 81 LLAPSGLSAinlVNSAVLA---TGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQPS--DKTKLLWLEAAG 155
Cdd:PRK07504 84 RATASGMAA---VTAAILCqvkAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAvrPNTKVFFLESPT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 156 SVTLEFPDLKALVKKAKAHGVLTALDNT-----WGAGLAFNAfnfsdehlsvDLTIHALTKYPSGGGDILMGSVVTR--- 227
Cdd:PRK07504 161 NPTLEVIDIAAVAKIANQAGAKLVVDNVfatplFQKPLELGA----------HIVVYSATKHIDGQGRCLGGVVLSDkaw 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 228 -DEKLHHrLFRMhaiLGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGhqywQEIC 306
Cdd:PRK07504 231 iEEHLQD-YFRH---TGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQ----ADII 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 307 STGRSAGLVSVVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKLENTH-----LQQGLLvRFCIGLED 381
Cdd:PRK07504 303 AKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEAraelgISEGFL-RLSAGLED 381
|
410
....*....|....
gi 446639170 382 PQDLIQDIENALKQ 395
Cdd:PRK07504 382 TDDLIEDLAAALKK 395
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
28-394 |
7.26e-23 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 99.43 E-value: 7.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 28 PLFRASTIIFKSTSH---LFDrhwTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEV 104
Cdd:PRK08134 30 PIHLTTSFVFRDSDHaaaLFN---LERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHLAIATLMGAGSHI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 105 WVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQPSDK--TKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDN 182
Cdd:PRK08134 107 VASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRpnTRLLFGETLGNPGLEVLDIPTVAAIAHEAGVPLLVDS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 183 TWGAGLAFNAFNfsdehLSVDLTIHALTKYPSGGGDILMGSVV---TRD--------------EKLHHRLF--------- 236
Cdd:PRK08134 187 TFTTPYLLRPFE-----HGADLVYHSATKFLGGHGTAIGGVLVdggRFDweasgkfpeltepyAGFHGMVFaeestvaaf 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 237 ----RMHAI--LGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICStgR 310
Cdd:PRK08134 262 llraRREGLrdFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHALAKRLLP--R 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 311 SAGLVsVVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVmlydlkmMRKLENTHLQ------------QGlLVRFCIG 378
Cdd:PRK08134 340 GAGSV-FSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLV-------IHPASTTHFRmdaaalaaagigEG-TIRLSIG 410
|
410
....*....|....*.
gi 446639170 379 LEDPQDLIQDIENALK 394
Cdd:PRK08134 411 LEDADDLIDDLKRALK 426
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
33-393 |
8.07e-23 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 98.75 E-value: 8.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 33 STIIFKSTSHlfdrHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYG 112
Cdd:PRK06460 20 TTPIYQTTAY----HYPEGEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNSVLVHRDMFG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 113 PNLEHL-NYLKDqYGINVQVYNPIDVSSFQ--PSDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDNTWGAgla 189
Cdd:PRK06460 96 RSYRFFtDYLKN-WGVNVDASNPGSDNIIEkaKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFST--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 190 fnAFNFSDEHLSVDLTIHALTKYPSGGGDILMGsVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQS 269
Cdd:PRK06460 172 --PINQKPLELGADIVVHSASKFLAGHNDVIAG-LAAGYGKLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVIN 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 270 NNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICSTgrSAGLVSVVFKSDYDiSAVRRFcDALKLFKLGFSWGGPVS 349
Cdd:PRK06460 249 RNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKG--FGGVLSFEVNGGQE-SALKVM-KSLKLIIPAQTLGGVNS 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446639170 350 LVMLYDLKMMRKLENTHLQ-QGL---LVRFCIGLEDPQDLIQDIENAL 393
Cdd:PRK06460 325 VISHPATMSHRTLSLEERKiVGItdsLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
7-390 |
1.63e-22 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 98.67 E-value: 1.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 7 FQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSH---LFDrhWTDPYDYsYGTHGTPTTFTLGDNIAQIEGGLYCLLA 83
Cdd:PRK07812 14 FETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHaaaLFG--LAEPGNI-YTRIMNPTQDVVEQRIAALEGGVAALLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 84 PSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQ-VYNPIDVSSFQPS--DKTKLLWLEAAGSVTLE 160
Cdd:PRK07812 91 ASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSfVEDPDDLDAWRAAvrPNTKAFFAETISNPQID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 161 FPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSVV--------------- 225
Cdd:PRK07812 171 VLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPL----EH-GADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgf 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 226 -TRDEKLHHRLF------------RMHAI--LGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLH 290
Cdd:PRK07812 246 tTPDPSYHGVVFaelgppayalkaRVQLLrdLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNY 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 291 PSDKASPGHQYWQEICSTGrsAGLVsVVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVmlydlkmMRKLENTHLQ-- 368
Cdd:PRK07812 326 AGLPSSPWYERAKRLAPKG--TGAV-LSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLV-------IHPASTTHSQlt 395
|
410 420 430
....*....|....*....|....*....|.
gi 446639170 369 --QGL-------LVRFCIGLEDPQDLIQDIE 390
Cdd:PRK07812 396 peEQLatgvtpgLVRLAVGIEGIDDILADLE 426
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
1-395 |
5.18e-21 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 94.14 E-value: 5.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKHNNFQ--TQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGL 78
Cdd:PRK08248 1 MSEERTFRleTLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 79 YCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYNPIDVSSFQP--SDKTKLLWLEAAGS 156
Cdd:PRK08248 81 GALAVSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAaiTDKTKALFAETIGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 157 VTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNFsdehlSVDLTIHALTKYPSGGGDILMGSVV----------- 225
Cdd:PRK08248 161 PKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEH-----GADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsg 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 226 -----TRDEKLHHRLFRMHAI----------------LGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQ 284
Cdd:PRK08248 236 kfpglTEPDPSYHGLVYTDAVgeaayitkarvqllrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 285 FAQVLHPSDKASPGHQYWQEICSTGRSAGLvsvVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKL-E 363
Cdd:PRK08248 316 VEWVSYPGLPSHPSYELAKKYLPKGQGAIL---TFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLsE 392
|
410 420 430
....*....|....*....|....*....|....*
gi 446639170 364 NTHLQQGL---LVRFCIGLEDPQDLIQDIENALKQ 395
Cdd:PRK08248 393 EEQLAAGVtpgLVRLSVGTEAIDDILDDLRQAIRQ 427
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
54-300 |
1.70e-20 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 92.52 E-value: 1.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 54 YSYGTHGTPTTFTLGDNIAQIEG--GLYCllAPSGLSAINLVNSAVLATGDEVWVPDNIYGPN---LEHlnYLKDQYGIN 128
Cdd:PLN02242 68 YIYSRHFNPTVLNLGRQMAALEGteAAYC--TASGMSAISSVLLQLCSSGGHVVASNTLYGGThalLAH--FLPRKCNIT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 129 ---VQVYNPIDVSSFQPSDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDNTwgaglaFNAFNFSDEHLSVDLT 205
Cdd:PLN02242 144 ttfVDITDLEAVKKAVVPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNT------FAPMVLSPARLGADVV 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 206 IHALTKYPSGGGDILMGSVVTrDEKLHHRLFRMHA----ILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKE 281
Cdd:PLN02242 218 VHSISKFISGGADIIAGAVCG-PAELVNSMMDLHHgalmLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKE 296
|
250
....*....|....*....
gi 446639170 282 QPqfAQVLHPSDKASPGHQ 300
Cdd:PLN02242 297 LG--LKVIYPGLEDHPQHA 313
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
25-393 |
7.76e-20 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 90.50 E-value: 7.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 25 VQPPLFRASTIIFKSTS---HLFDR---------HWTDPYDYSYGTHgtPTTFTLGDNIAQIEGGLYCLLAPSGLSAINL 92
Cdd:PRK07049 36 VKPPVFLTSTFVFRSAEdgrDFFDYvsgrkeppaGEGAGLVYSRFNH--PNSEIVEDRLAVYEGAESAALFSSGMSAIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 93 VNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGIN-VQVYNPIDVSSFQPS-------DKTKLLWLEAAGSVTLEFPDL 164
Cdd:PRK07049 114 TLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSEAAIGAAaeaaaakGRVSLILIETPANPTNSLVDV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 165 KALVKKAKA------HGVLTALDNTwgagLAFNAFNFSDEHlSVDLTIHALTKYPSGGGDILMGSVVTRdEKLHHRLFRM 238
Cdd:PRK07049 194 AAVRRVADAiearqgHRPIIACDNT----LLGPVFQKPLEH-GADLSVYSLTKYVGGHSDLVAGAVLGR-KALIRQVRAL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 239 HAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQV-LHP-SDKASPGHQYWQEICSTGRSAglVS 316
Cdd:PRK07049 268 RSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLhYLPfLDPDSAYGAVYKRQCTGAGST--FS 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 317 VVFKSDYDisAVRRFCDALKLFKLGFSWGGPVSLVMlYDLKMmrklenTHL------QQGL-----LVRFCIGLEDPQDL 385
Cdd:PRK07049 346 FDIKGGQA--AAFRFLNALQIFKLAVSLGGTESLAS-HPASM------THSgvpadvRERIgvlesTIRLSIGIEHPDDL 416
|
....*...
gi 446639170 386 IQDIENAL 393
Cdd:PRK07049 417 IADLAQAL 424
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
1-396 |
4.20e-17 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 82.61 E-value: 4.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 1 MKKHNN-------FQTQLIHAPRKAPQFIETVQPPLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQ 73
Cdd:PRK05613 1 MPKYDNsnadqwgFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 74 IEGGLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQ-VYNPIDVSSFQPS--DKTKLLW 150
Cdd:PRK05613 81 LEGGVHAVAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTfVENPDDPESWQAAvqPNTKAFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 151 LEAAGSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFnfsdeHLSVDLTIHALTKYPSGGGDILMGSV------ 224
Cdd:PRK05613 161 GETFANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPL-----ELGADVVVASLTKFYTGNGSGLGGVLidggkf 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 225 ---VTRD-----------EKLHHRL---------FRMHAILGI------SVSGDDTAQIQRSLAHMSLRYEQQSNNAKTL 275
Cdd:PRK05613 236 dwtVERDgkpvfpyfvtpDPAYHGLkyadlgapaFGLKARAGLlrdtgaTLSPFNAWVTAQGLDTLSLRLERHNENAIKV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 276 LTWLKEQPQFAQVLHPSDKASPghqyWQeicSTGRSAGLVSVVFKSDYDISAVR----RFCDALKLFKLGFSWGGPVSLV 351
Cdd:PRK05613 316 AEFLNNHEKVAKVNFAGLKDSP----WY---ATKEKLGLKYTGSVLSFDIKGGKdeawAFIDALKLHSNLANIGDVRSLV 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 446639170 352 mlydlkmMRKLENTHLQ---QGLL--------VRFCIGLEDPQDLIQDIENALKQM 396
Cdd:PRK05613 389 -------VHPATTTHSQsdeAGLAragitqatVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
28-393 |
1.16e-16 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 81.25 E-value: 1.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 28 PLFRASTIIFKSTSHLFDRHWTDPYDYSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEVWVP 107
Cdd:PRK06702 27 PLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNICSSGDHLLCS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 108 DNIYGPNLEHLNYLKDQYGINVQVYNP---IDVSSFQPSDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDNTW 184
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKLGIDVTFFNPnltADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 185 GAGLAFNAFnfsdEHlSVDLTIHALTKYPSGGGDILMGSVV---------------TRDEKLHHRLFRMHAILGISVSGD 249
Cdd:PRK06702 187 ATPYLCQAF----EH-GANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSYHGVSYVQNFGAAAYIVK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 250 DTAQIQRS----------------LAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHPSDKASPGHQYWQEICSTGRSAG 313
Cdd:PRK06702 262 ARVQLLRDygncmspfnayisnigLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKKGASGV 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 314 LvsvVFKSDYDISAVRRFCDALKLFKLGFSWGGPVSLVMLYDLKMMRKL--ENTHLQ--QGLLVRFCIGLEDPQDLIQDI 389
Cdd:PRK06702 342 L---TFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLsaEDQRLAgvTSDLIRLSVGIEDVSDIIADL 418
|
....
gi 446639170 390 ENAL 393
Cdd:PRK06702 419 EAAL 422
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
54-394 |
1.47e-16 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 80.55 E-value: 1.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 54 YSYGTHGTPTTFTLGDNIAQIEGGLYCLLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPNLEHLNYLKDQYGINVQVYN 133
Cdd:PRK07810 62 FVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVD 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 134 PIDVSSFQP--SDKTKLLWLEAAGSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNfsdehLSVDLTIHALTK 211
Cdd:PRK07810 142 GEDLSQWEEalSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLP-----LGADVVVYSGTK 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 212 YPSGGGDILMGSVVTRDEKLHHRLFRMHAILGISVSGDDTAQIQRSLAHMSLRYEQQSNNAKTLLTWLKEQPQFAQVLHP 291
Cdd:PRK07810 217 HIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 292 SDKASPGHqywqEICSTGRSAGLVSVVFKSDYDISAVRR----FCDALKLFKLGFSWGGPVSLVMlydlkmmRKLENTHL 367
Cdd:PRK07810 297 FLPSHPQY----DLAKRQMSGGGTVVTFELDAPEDAAKKrafeVLDKLRVIDISNNLGDAKSLIT-------HPATTTHR 365
|
330 340 350
....*....|....*....|....*....|....*...
gi 446639170 368 QQGL-----------LVRFCIGLEDPQDLIQDIENALK 394
Cdd:PRK07810 366 AMGPegraaiglgdgVVRLSVGLEDTDDLIADLDRALG 403
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
84-221 |
2.24e-07 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 50.46 E-value: 2.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 84 PSGLSAINLVNSAVLATGDEVWVPDNIY-----------GPNLEHLNYLKDQYGINvqvyNPIDVSSFQPSDKTKLLWLE 152
Cdd:cd01494 24 PSGTGANEAALLALLGPGDEVIVDANGHgsrywvaaelaGAKPVPVPVDDAGYGGL----DVAILEELKAKPNVALIVIT 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446639170 153 AAGSVTLEFPDLKALVKKAKAHGVLTALDNTWGAGLAFNAFNFSDEHlSVDLTIHALTKY--PSGGGDILM 221
Cdd:cd01494 100 PNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLIPEG-GADVVTFSLHKNlgGEGGGVVIV 169
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
81-283 |
5.37e-03 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 38.48 E-value: 5.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 81 LLAPSGLSAINLVNSAVLATGDEVWVPDNIYGPnleHLNYLKdQYGINVqVYNPIDVSSFQPSD----------KTKLLW 150
Cdd:cd00609 63 VVTNGAQEALSLLLRALLNPGDEVLVPDPTYPG---YEAAAR-LAGAEV-VPVPLDEEGGFLLDlelleaaktpKTKLLY 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 151 LEAA----GSVtLEFPDLKALVKKAKAHGVLTALDNtwgaglAFNAFNFSDEHLSVD---------LTIHALTKYPSGGG 217
Cdd:cd00609 138 LNNPnnptGAV-LSEEELEELAELAKKHGILIISDE------AYAELVYDGEPPPALalldayervIVLRSFSKTFGLPG 210
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446639170 218 dILMGSVVTRDEKLHHRLFRMHAILGISVSGddTAQI---------QRSLAHMSLRYEQqsnNAKTLLTWLKEQP 283
Cdd:cd00609 211 -LRIGYLIAPPEELLERLKKLLPYTTSGPST--LSQAaaaaalddgEEHLEELRERYRR---RRDALLEALKELG 279
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
81-210 |
8.50e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 38.06 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446639170 81 LLAPSGLSAINLVNSAVLATGDEVWVPDNIYGpnlEHLNYLKDqYGINVQVYNPIDVSSFQP---------SDKTKLLWL 151
Cdd:pfam00155 67 VFGSGAGANIEALIFLLANPGDAILVPAPTYA---SYIRIARL-AGGEVVRYPLYDSNDFHLdfdaleaalKEKPKVVLH 142
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446639170 152 EAAGSVT---LEFPDLKALVKKAKAHGVLTALDNTWgAGLAFNAFNFSDEHLSVDLTIHALT 210
Cdd:pfam00155 143 TSPHNPTgtvATLEELEKLLDLAKEHNILLLVDEAY-AGFVFGSPDAVATRALLAEGPNLLV 203
|
|
| |
