|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
170-501 |
1.65e-71 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 232.52 E-value: 1.65e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 170 ITIEGKNLYMFVSGIPEGEVIYDTQEGPFPFLIGVLVFIFSFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDEI 249
Cdd:COG5002 58 LLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 250 AALTENINNMAEELMNNIEKERKLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHDEYTRIAFAKSEQLKN 329
Cdd:COG5002 138 LSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSR 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 330 LIEDLFEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYS 409
Cdd:COG5002 218 LVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYT 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 410 KDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSIRAEYR--D 487
Cdd:COG5002 298 PEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEpgK 377
|
330
....*....|....
gi 446641859 488 GTIqFIVSLPIIEK 501
Cdd:COG5002 378 GTT-FTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
262-500 |
1.04e-67 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 217.47 E-value: 1.04e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 262 ELMNNIEKERKLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHDEYTRIAFAKSEQLKNLIEDLFEYTKLT 341
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 342 NEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQR 421
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 422 QRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvTEGSGLGLAIAKSIVELQGGSIRAEYRD--GTIqFIVSLPII 499
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPggGTT-FTVTLPLA 237
|
.
gi 446641859 500 E 500
Cdd:COG2205 238 E 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
250-498 |
2.47e-55 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 188.19 E-value: 2.47e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 250 AALTENINNMAEELMNNIEKERKLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKyenKEQHDEYTRIAFAKSEQLKN 329
Cdd:COG0642 83 LLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL---DEEQREYLETILRSADRLLR 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 330 LIEDLFEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYS 409
Cdd:COG0642 160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 410 KDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvTEGSGLGLAIAKSIVELQGGSIRAEYRDGT 489
Cdd:COG0642 240 PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
250
....*....|
gi 446641859 490 -IQFIVSLPI 498
Cdd:COG0642 318 gTTFTVTLPL 327
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
268-497 |
4.23e-37 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 144.12 E-value: 4.23e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 268 EKErKLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHDEYTRIAFAKSEQLKNLIEDLFEYTKLTNEQVVL 347
Cdd:NF033092 364 EQE-KIEQERREFVANVSHELRTPLTTMRSYLEALADGAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKL 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 348 EKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQ 427
Cdd:NF033092 443 NKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRII 522
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446641859 428 IVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSIRAEYRDG---TIQFivSLP 497
Cdd:NF033092 523 ISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGkgtTIYF--TLP 593
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
26-497 |
1.14e-36 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 140.99 E-value: 1.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 26 RKSIRIQLITTFAACALLGVLSAKAAApffenanrqatidYRAGMEQINHQAQGAANSsvhenKLEAISNMIEMEN---- 101
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFML-------------YSSLERHFEERDREELQG-----KLEQVRRFLRDPAdlde 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 102 ---------QNLEQGSRALKILVTDESGKVLYKTKQAQEEQIDLHNtirNAASFAINYTDGRNVFESTRKEFISFSPITI 172
Cdd:TIGR01386 63 dikrlqekiDDLLVGHSDLALSILNPDGRLLFERAQGAALVPAVAA---NDALLELDQADAKMTHYRSILRSVAALPGGK 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 173 EGKNLYMFVSGIPEGEVIYDTQEGPFPFLIGVLVFIFSFF---YITKRKMKQIEAMAQGVKEIERGNLAYRI-EKKGEDE 248
Cdd:TIGR01386 140 GRKPVQITVALDINAHTHLLDALRKWLILIAVLLVLLTALlgwWITRLGLEPLRRLSAVAARISPESLDQRLdPSRAPAE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 249 IAALTENINNMAEELMnniEKERKLEkqknELITNVSHDLRTPLTSIMGY----LRLLRDSkyenkeqhDEYTRIAFAKS 324
Cdd:TIGR01386 220 LRELAQSFNAMLGRLE---DAFQRLS----QFSADLAHELRTPLTNLLGQtqvaLSQPRTG--------EEYREVLESNL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 325 EQLKNL---IEDLFEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKkfpEERAYASIDSEKMVRVFDNL 401
Cdd:TIGR01386 285 EELERLsrmVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRV---EGEGLVRGDPQMFRRAISNL 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 402 LMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSI 481
Cdd:TIGR01386 362 LSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRA 441
|
490
....*....|....*.
gi 446641859 482 RAEYRDGTIQFIVSLP 497
Cdd:TIGR01386 442 SAESPDGKTRFILRFP 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
201-501 |
7.73e-32 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 126.62 E-value: 7.73e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 201 LIGVLVFIFSFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAALTENINNMAEEL---MNNIEKERK----- 272
Cdd:COG5000 16 LLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLkeqREELEERRRyleti 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 --------------------------------------------------------------------------------
Cdd:COG5000 96 lenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtllvras 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 273 -----------------LEKQKN----ELITNVSHDLRTPLTSIMGYL----RLLRDSKYENKEQHDEYTRIAFAKSEQL 327
Cdd:COG5000 176 plrddgyvivfdditelLRAERLaawgELARRIAHEIKNPLTPIQLSAerlrRKLADKLEEDREDLERALDTIIRQVDRL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 328 KNLIEDLFEYTKLTNeqvvLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIK 407
Cdd:COG5000 256 KRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIE 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 408 YSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFY--KKdqsrsrvtEGSGLGLAIAKSIVELQGGSIRAEY 485
Cdd:COG5000 332 AIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFttKP--------KGTGLGLAIVKKIVEEHGGTIELES 403
|
410
....*....|....*...
gi 446641859 486 RD--GTiQFIVSLPIIEK 501
Cdd:COG5000 404 RPggGT-TFTIRLPLAEE 420
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
267-481 |
1.22e-31 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 124.24 E-value: 1.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 267 IEKERKLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHDEYTRIAFAKSEQLKNLIEDLFEYTKLTNEQVV 346
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 347 LEKQEVCVNELLEQLIEELVPQAEEHGLTFVkkFPEERAYASIDSEKMVR-VFDNLLMNAIKYSKDDGEIKVSLQRQRRD 425
Cdd:TIGR02966 184 LEDEPVDMPALLDHLRDEAEALSQGKNHQIT--FEIDGGVDVLGDEDELRsAFSNLVSNAIKYTPEGGTITVRWRRDGGG 261
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 446641859 426 IQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSI 481
Cdd:TIGR02966 262 AEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARL 317
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
26-497 |
1.43e-31 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 127.45 E-value: 1.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 26 RKSIR-----IQLITTFAACALLG-VLSAKAAAPFFENANRQATIDYRAGMEQINHQAQGAANSSVHENKLEAISNMIEM 99
Cdd:NF040691 2 RRSLQlrvvaITLLLSLVVILVLGvVLALQITNGLLDNRVDAALGDSRRARTQAQSQLNASDASTSDSAQQLLRTTLLSV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 100 ENQNLEQGSRALKILV-----------TDESGKV--LYKTKQAQEEQIDLHNTIRNAASFAINYTDGrnvfeSTRKEFIS 166
Cdd:NF040691 82 LASASGAMQGAFDVVLlvpgddpsglgPRASGSVglVSQIPEELREAVAGGQVAQQYQSVALPSGDG-----SSAPALVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 167 FSPITIEGKN---LYMFVSGIPEGEVIYDTQeGPFPF-------LIGVLVFIfsffyITKRKMKQIEAMAQGVKEIERGN 236
Cdd:NF040691 157 GTPVTLPVAGnyeLYLLFPLEDEQSTLALVR-GTLLLgglalvvLLGLIAWL-----VTRQVVAPVRSAARTAERFAAGD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 237 LAYRIEKKGEDEIAALTENINNMAEELMNNIEKERKLEKQKNELITNVSHDLRTPLTSImgylRLLRDSKYENKEQHDEY 316
Cdd:NF040691 231 LSERMPVKGEDDLARLARSFNQMADSLQRQIRQLEELSRLQQRFVSDVSHELRTPLTTI----RMAADVIHDSRDDFDPA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 317 TRIA----FAKSEQLKNLIEDLFEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSE 392
Cdd:NF040691 307 TARSaellHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPR 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 393 KMVRVFDNLLMNAIKYSkDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKS 472
Cdd:NF040691 387 RVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALE 465
|
490 500
....*....|....*....|....*.
gi 446641859 473 IVELQGGSIRAEYRDGT-IQFIVSLP 497
Cdd:NF040691 466 DARLHGGWLEAWGRPGQgSQFRLTLP 491
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
10-498 |
3.30e-30 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 123.36 E-value: 3.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 10 YIRKIRELFEKLVKSVRKSIRIQLITTFAACALLGVLSAKAAAPFFENANRQATIDYRAGMEQINHQAQGAANSSVHENK 89
Cdd:COG4251 2 LLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 90 LEAISNMIEMENQNLEQGSRALKILVTDESGKVLYKTKQAQEEQIDLHNTIRNAASFAINYTDGRNVFESTRKEFISFSP 169
Cdd:COG4251 82 LLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 170 ITIEGKNLYMFVSGIPEGEVIYDTQEGPFPFLIGVLVFIFSFFYITKRKMKQIEAMAQGVKE---IERGNLAYRIEKKGE 246
Cdd:COG4251 162 LLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGglgLLLLLLLLLVLLLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 247 DEIAALTENINNMAEELMNNIEKERKLEKQKNEL-ITN---------VSHDLRTPLTSIMGYLRLLRDsKYENK--EQHD 314
Cdd:COG4251 242 ILLLLLLILVLELLELRLELEELEEELEERTAELeRSNeeleqfayvASHDLREPLRKISGFSQLLEE-DYGDKldEEGR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 315 EYTRIAFAKSEQLKNLIEDLFEYTKLTNEQvvLEKQEVCVNELLEQLIEELVPQAEEHGLTF-VKKFPEERAyasiDSEK 393
Cdd:COG4251 321 EYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIeVGPLPTVRG----DPTL 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSKDD--GEIKVSLQRQRRDIQIVIANH----SEEFtREELANLFERFYKKDQSrsrvtEGSGLGL 467
Cdd:COG4251 395 LRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNgigiDPEY-AEKIFEIFQRLHSRDEY-----EGTGIGL 468
|
490 500 510
....*....|....*....|....*....|...
gi 446641859 468 AIAKSIVELQGGSIRAEYR--DGTIqFIVSLPI 498
Cdd:COG4251 469 AIVKKIVERHGGRIWVESEpgEGAT-FYFTLPK 500
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
235-500 |
2.09e-28 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 117.43 E-value: 2.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 235 GNLAYRIEKKGEDEIAALTENINNMAEELMNNiekerklEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYEnkeqhd 314
Cdd:PRK10549 205 GDFTTRVTPTSRDELGRLAQDFNQLASTLEKN-------EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK------ 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 315 eytriafAKSEQLKNLIEDLFEYTKLTNE--QVVL--------EKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEEr 384
Cdd:PRK10549 272 -------FTPESVASLQAEVGTLTKLVDDlhQLSLsdegalayRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDS- 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 385 ayASI--DSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEG 462
Cdd:PRK10549 344 --ATVfgDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGG 421
|
250 260 270
....*....|....*....|....*....|....*....
gi 446641859 463 SGLGLAIAKSIVELQGGSIRAEYRD-GTIQFIVSLPIIE 500
Cdd:PRK10549 422 SGLGLAICLNIVEAHNGRIIAAHSPfGGVSITVELPLER 460
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
394-497 |
1.88e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 100.15 E-value: 1.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvTEGSGLGLAIAKSI 473
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....
gi 446641859 474 VELQGGSIRAEYRDGTIQFIVSLP 497
Cdd:cd16923 79 IELHGGSASAEYDDNHDLFKVRLP 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
389-498 |
4.19e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 99.65 E-value: 4.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 389 IDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQsRSRVTEGSGLGLA 468
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 446641859 469 IAKSIVELQGGSIRAEYRD--GTIqFIVSLPI 498
Cdd:smart00387 80 IVKKLVELHGGEISVESEPggGTT-FTITLPL 110
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
205-497 |
3.54e-24 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 105.24 E-value: 3.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 205 LVFIFSFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGED-EIAALTENINNMAEELmnniekERKLEKQKNeLITN 283
Cdd:PRK09835 196 LLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERI------EDVFTRQSN-FSAD 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 284 VSHDLRTPLTSIMGYLRL----------LRDSKYENKEqhdEYTRIAfakseqlkNLIEDLFEYTKLTNEQVVLEKQEVC 353
Cdd:PRK09835 269 IAHEIRTPITNLITQTEIalsqsrsqkeLEDVLYSNLE---ELTRMA--------KMVSDMLFLAQADNNQLIPEKKMLD 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 354 VNELLEQLIEELVPQAEEHGLTFvkKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANH 433
Cdd:PRK09835 338 LADEVGKVFDFFEAWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENP 415
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446641859 434 SEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSIRAEYRDGTIQFIVSLP 497
Cdd:PRK09835 416 GTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
246-498 |
3.71e-24 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 103.72 E-value: 3.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 246 EDEIAALTENINNMAEELMNNIEKERKLEKQ-----K----NELITNVSHDLRTPLTSIMGYLRLLRD--SKYENKEQHD 314
Cdd:COG4191 102 DAEENAELEELERDITELERAEEELRELQEQlvqseKlaalGELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELR 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 315 EYTRIAFAKSEQLKNLIEDLFEYTKLTNEqvvlEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKM 394
Cdd:COG4191 182 EALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQL 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 395 VRVFDNLLMNAIK--YSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFY--KkdqsrsRVTEGSGLGLAIA 470
Cdd:COG4191 258 EQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttK------PVGKGTGLGLSIS 331
|
250 260 270
....*....|....*....|....*....|
gi 446641859 471 KSIVELQGGSIRAEYR--DGTIqFIVSLPI 498
Cdd:COG4191 332 YGIVEKHGGRIEVESEpgGGTT-FTITLPL 360
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
268-501 |
7.63e-22 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 96.84 E-value: 7.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 268 EKERKLEKQK--NELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQhdEYTRIAFAKSEQLKNLIEDLFEYTKltneQV 345
Cdd:COG3852 124 RELRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELR--EYTQLIIEEADRLNNLVDRLLSFSR----PR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 346 VLEKQEVCVNELLEQLIEELVPQAEeHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLqRQRRD 425
Cdd:COG3852 198 PPEREPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRT-RVERQ 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 426 IQIVIANHSEEF-----------TREELANLFERFY--KKdqsrsrvtEGSGLGLAIAKSIVELQGGSIRAEYRDG--TI 490
Cdd:COG3852 276 VTLGGLRPRLYVrievidngpgiPEEILDRIFEPFFttKE--------KGTGLGLAIVQKIVEQHGGTIEVESEPGkgTT 347
|
250
....*....|.
gi 446641859 491 qFIVSLPIIEK 501
Cdd:COG3852 348 -FRIYLPLEQA 357
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
390-497 |
1.52e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 89.44 E-value: 1.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 390 DSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAI 469
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 446641859 470 AKSIVELQGGSIRAEYRD-GTIQFIVSLP 497
Cdd:cd16946 81 CHNIALAHGGTISAEHSPlGGLRLVLTLP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
178-498 |
4.65e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 95.44 E-value: 4.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 178 YMFVSGIPEGEviYDTQEGPFPFL----------IGVLVFI-FS-----FFYITK--RKMKQIEAMAQGVKEierGNLAY 239
Cdd:PRK10604 107 YTFLQRIPRSH--YVLAVGPVPYLyylhqmrlldIALLALIgLSlafpvFLWMRPhwQDMLKLEAAAQRLGD---GHLAE 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 240 RIEKKGEDEIAALTENINNMAEelmnNIEKerkLEKQKNELITNVSHDLRTPLtsimgyLRLlrdsKY--ENKEQHDEYT 317
Cdd:PRK10604 182 RIHFDEGSSLERLGVAFNQMAD----NINA---LIASKKQLIDGIAHELRTPL------VRL----RYrlEMSDNLSAAE 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 318 RIAFAKS-EQLKNLIEDLFEYTKLTNEQVVLEKQEVcvNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVR 396
Cdd:PRK10604 245 SQALNRDiGQLEALIEELLTYARLDRPQNELHLSEP--DLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMER 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 397 VFDNLLMNAIKYSkdDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVEL 476
Cdd:PRK10604 323 VLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALA 400
|
330 340
....*....|....*....|...
gi 446641859 477 QGGSIRAEYRD-GTIQFIVSLPI 498
Cdd:PRK10604 401 MGGSVNCDESElGGARFSFSWPV 423
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
390-497 |
7.95e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 87.42 E-value: 7.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 390 DSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRrDIQIVIANHSEEFTREELANLFERFYkkdQSRSRVTEGSGLGLAI 469
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFS---TADKRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|
gi 446641859 470 AKSIVELQGGSIRAEYRD--GTIqFIVSLP 497
Cdd:pfam02518 78 VRKLVELLGGTITVESEPggGTT-VTLTLP 106
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
194-482 |
1.08e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 94.21 E-value: 1.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 194 QEGPFPFL------IGVLVFIFSFFYITK--RKMKQIEAMAQGVKeieRGNLAYRIEKKGEDEIAALTENINNMAEELmn 265
Cdd:PRK09467 148 HQGDFSPLfrytlaIGLLSVAGGWLFIRIqnRPLVALEHAALQVG---KGEIPPPLREYGASEVRSVTRAFNQMAAGI-- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 266 niekeRKLEKQKNELITNVSHDLRTPLTSImgylRLlrdsKYENKEQHDEYTRIAFAKS-EQLKNLIEDLFEYTKLTNEQ 344
Cdd:PRK09467 223 -----KQLEDDRTLLMAGVSHDLRTPLTRI----RL----ATEMMSEEDGYLAESINKDiEECNAIIEQFIDYLRTGQEM 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 345 VvleKQEVCVNelleqLIEELVPQAE-EHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKddGEIKVSLQRQR 423
Cdd:PRK09467 290 P---MEMADLN-----ALLGEVIAAEsGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEG 359
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 446641859 424 RDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvTEGSGLGLAIAKSIVELQGGSIR 482
Cdd:PRK09467 360 KRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVE 416
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
396-497 |
1.35e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 86.61 E-value: 1.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 396 RVFDNLLMNAIKYSkdDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVE 475
Cdd:cd16949 3 RALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|...
gi 446641859 476 LQGGSIRAEYRD-GTIQFIVSLP 497
Cdd:cd16949 81 QHGGKIKASNRKpGGLRVRIWLP 103
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
271-471 |
1.81e-20 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 93.54 E-value: 1.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 271 RKLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHdeytRIAFAKSEQLK---NLIEDLFEYTKLT------ 341
Cdd:PRK11006 198 HQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALRE----KALHTMREQTQrmeGLVKQLLTLSKIEaaptid 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 342 -NEQV-------VLEKQEVCVNElleqlieelvpqaEEHGLTFvkkfpeerayasiDSEKMVRVF----------DNLLM 403
Cdd:PRK11006 274 lNEKVdvpmmlrVLEREAQTLSQ-------------GKHTITF-------------EVDNSLKVFgnedqlrsaiSNLVY 327
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446641859 404 NAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAK 471
Cdd:PRK11006 328 NAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVK 395
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
234-498 |
4.13e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 92.69 E-value: 4.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 234 RGNLAYRIE-KKGEDEIAALTENINNMAEELmnniekERKLEKQKnELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEq 312
Cdd:PRK09470 206 QGNLRQHPElETGPQEFRQAGASFNQMVTAL------ERMMTSQQ-RLLSDISHELRTPLTRLQLATALLRRRQGESKE- 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 313 hdeYTRIAfAKSEQLKNLIEDLFEytkLTNEQV--VLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASID 390
Cdd:PRK09470 278 ---LERIE-TEAQRLDSMINDLLV---LSRNQQknHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGN 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 391 SEKMVRVFDNLLMNAIKYSKDdgEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIA 470
Cdd:PRK09470 351 PNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIV 428
|
250 260
....*....|....*....|....*....
gi 446641859 471 KSIVELQGGSIRAEYRD-GTIQFIVSLPI 498
Cdd:PRK09470 429 ENAIQQHRGWVKAEDSPlGGLRLTIWLPL 457
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
279-501 |
1.71e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 91.57 E-value: 1.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 279 ELITNVSHDLRTPLTSIMGYLRLLRdsKYENKEQHDEYTRIAFAKSEQLKNLIEDLFEYTKLTNEQVvlekQEVCVNELL 358
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWR--QQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQW----QPVSLNALV 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 359 EQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIV-IANHSEEF 437
Cdd:PRK11360 466 EEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVsIEDNGCGI 545
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446641859 438 TREELANLFERFYKKDQSrsrvteGSGLGLAIAKSIVELQGGSIRAEYR--DGTIqFIVSLPIIEK 501
Cdd:PRK11360 546 DPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEpgVGTT-FTLYLPINPQ 604
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
201-488 |
9.80e-19 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 88.75 E-value: 9.80e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 201 LIGVLVFIFSFF-YITKRKMKQIEAMAQGVKEIERGNLAYRiekkGEDEIAALTENINNMAEEL--MNNIEKerklekqk 277
Cdd:PRK11100 191 LLGIALLIGAGVvWWLNRSIRRLTRYADAVTEGKPVPLPKL----GSSELRELAQALESMRVKLegKAYVEQ-------- 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 278 neLITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHdeytriaFAK-----SEQLKNLIEDLFEYTKLTNEQVVLEKQEV 352
Cdd:PRK11100 259 --YVQTLTHELKSPLAAIRGAAELLQEDPPPEDRAR-------FTGniltqSARLQQLIDRLLELARLEQRQELEVLEPV 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 353 CVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYAsiDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIAN 432
Cdd:PRK11100 330 ALAALLEELVEAREAQAAAKGITLRLRPDDARVLG--DPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVED 407
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446641859 433 HSE---EFTreeLANLFERFYkkdqSRSRVTEG---SGLGLAIAKSIVELQGGSIRAEYRDG 488
Cdd:PRK11100 408 QGPgipDYA---LPRIFERFY----SLPRPANGrksTGLGLAFVREVARLHGGEVTLRNRPE 462
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
262-498 |
3.27e-18 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 88.25 E-value: 3.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 262 ELMNNIEKERK----LEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYeNKEQHDEYTRIAFAKSEQLKNLIEDLFEY 337
Cdd:PRK09959 693 DLIHALEVERNkainATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGL-SKEQRVEAISLAYATGQSLLGLIGEILDV 771
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 338 TKLTNEQVVLEKQEVCVNELLEQL--IEELVPQAEEHGLTFVKKFPEERaYASIDSEKMVRVFDNLLMNAIKYSKdDGEI 415
Cdd:PRK09959 772 DKIESGNYQLQPQWVDIPTLVQNTchSFGAIAASKSIALSCSSTFPDHY-LVKIDPQAFKQVLSNLLSNALKFTT-EGAV 849
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 416 KVSLQRQRRD-----IQIVIANHSEEFTREELANLFERFYKKDQSRSRVteGSGLGLAIAKSIVELQGGSIRAEYRDGT- 489
Cdd:PRK09959 850 KITTSLGHIDdnhavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIg 927
|
....*....
gi 446641859 490 IQFIVSLPI 498
Cdd:PRK09959 928 TTFTITIPV 936
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
268-481 |
5.27e-18 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 85.77 E-value: 5.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 268 EKERKLE--KQKNELITNVSHDLRTPLT--SI------MGYLRLLRDSKYENKEQHDEYTRIAFAKSEQLknlIEDLFEY 337
Cdd:PRK09303 140 ENETLLEqlKFKDRVLAMLAHDLRTPLTaaSLaletleLGQIDEDTELKPALIEQLQDQARRQLEEIERL---ITDLLEV 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 338 TKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEE--RAYAsiDSEKMVRVFDNLLMNAIKYSKDDGEI 415
Cdd:PRK09303 217 GRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDlpSVYA--DQERIRQVLLNLLDNAIKYTPEGGTI 294
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446641859 416 KVS-LQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvTEGSGLGLAIAKSIVELQGGSI 481
Cdd:PRK09303 295 TLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEG--TEGYGIGLSVCRRIVRVHYGQI 359
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
390-497 |
1.46e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 78.30 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 390 DSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRD-IQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLA 468
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNrFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 446641859 469 IAKSIVELQGGSIR-AEYRDGTIQFIVSLP 497
Cdd:cd16925 81 IVKEFVELHGGTVTvSDAPGGGALFQVELP 110
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
270-481 |
1.71e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 85.76 E-value: 1.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 270 ERK-----LEK---QKNELITNVSHDLRTPLTSIMGYLRLLRDSKYeNKEQHdEYTRIAFAKSEQLKNLIEDLFEYTKLT 341
Cdd:PRK11091 268 ERKryqdaLEKasrDKTTFISTISHELRTPLNGIVGLSRILLDTEL-TAEQR-KYLKTIHVSAITLGNIFNDIIDMDKME 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 342 NEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKK----FPeerAYASIDSEKMVRVFDNLLMNAIKYSKdDGEIKV 417
Cdd:PRK11091 346 RRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEpllpLP---HKVITDGTRLRQILWNLISNAVKFTQ-QGGVTV 421
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446641859 418 SLQRQRRD-IQIVIANHSEEFTREELANLFERFYK-KDQSRSRVTEGSGLGLAIAKSIVELQGGSI 481
Cdd:PRK11091 422 RVRYEEGDmLTFEVEDSGIGIPEDELDKIFAMYYQvKDSHGGKPATGTGIGLAVSKRLAQAMGGDI 487
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
249-497 |
1.87e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 85.86 E-value: 1.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 249 IAALTENINNMAEELMNNIEKERklEKQKNELITNVSHDLRTPLTSIMGYLRLLR-DSKYENKEqhdeYTRIAFAKSEQL 327
Cdd:PRK10490 638 IANALERLTLTASEEQARLASER--EQLRNALLAALSHDLRTPLTVLFGQAEILTlDLASEGSP----HARQASEIRQQV 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 328 KN---LIEDLFEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFvkKFPEERAYASIDSEKMVRVFDNLLMN 404
Cdd:PRK10490 712 LNttrLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINL--SLPEPLTLIHVDGPLFERVLINLLEN 789
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 405 AIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvTEGSGLGLAIAKSIVELQGGSIRAE 484
Cdd:PRK10490 790 AVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAE 867
|
250
....*....|....
gi 446641859 485 YRD-GTIQFIVSLP 497
Cdd:PRK10490 868 NRPeGGACFRVTLP 881
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
258-498 |
6.43e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 83.10 E-value: 6.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 258 NMAEELMNNIEKERKLEKQKN-----ELITNVSHDLRTPLTSIMGYLRLLRDSKyenKEQHDEYTRIAFAKSEQLKNLIE 332
Cdd:COG5809 246 IIFRDITERKKLEELLRKSEKlsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTI---DEEQKTYLDIMLSELDRIESIIS 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 333 DLFEYTKLTNEQVvlekQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDD 412
Cdd:COG5809 323 EFLVLAKPQAIKY----EPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEG 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 413 GEIKVSLQRQRRD-IQIVIANHSEEFTREELANLFERFYkkdqsrSRVTEGSGLGLAIAKSIVELQGGSIRAEYRD--GT 489
Cdd:COG5809 399 GNITIETKAEDDDkVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVgkGT 472
|
....*....
gi 446641859 490 IqFIVSLPI 498
Cdd:COG5809 473 T-FSITLPI 480
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-486 |
9.33e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 76.40 E-value: 9.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 381 PEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVT 460
Cdd:cd16947 8 PDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAK 87
|
90 100
....*....|....*....|....*.
gi 446641859 461 EGSGLGLAIAKSIVELQGGSIRAEYR 486
Cdd:cd16947 88 QGNGLGLTITKRLAESMGGSIYVNSK 113
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
400-497 |
9.79e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 75.99 E-value: 9.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 400 NLLMNAIKYSkDDGEIKVSLQRQRRDIQIVIANHSEE-----FTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIV 474
Cdd:cd16922 7 NLLGNAIKFT-EEGEVTLRVSLEEEEEDGVQLRFSVEdtgigIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLV 85
|
90 100
....*....|....*....|....*
gi 446641859 475 ELQGGSIRAE--YRDGTIqFIVSLP 497
Cdd:cd16922 86 ELMGGDISVEsePGQGST-FTFTLP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
236-500 |
1.92e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 79.30 E-value: 1.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 236 NLAYRIEKKGEDE---IA----ALTENINNMAEELMNNIeKERKLE------------KQKNELITNVSHDLRTPLTSIM 296
Cdd:PRK15347 339 ALEPRLPENRLDElgsIAkaynQLLDTLNEQYDTLENKV-AERTQAlaeakqraeqanKRKSEHLTTISHEIRTPLNGVL 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 297 GYLRLLRDSKYENKEQhdEYTRIAFAKSEQLKNLIEDLFEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGL-- 374
Cdd:PRK15347 418 GALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLtl 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 375 -TFV-KKFPEeraYASIDSEKMVRVFDNLLMNAIKYSkDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKK 452
Cdd:PRK15347 496 rTFVgAHVPL---YLHLDSLRLRQILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQA 571
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446641859 453 DQSRSrvteGSGLGLAIAKSIVELQGGSI--RAEYRDGTiQFIVSLPIIE 500
Cdd:PRK15347 572 DTHSQ----GTGLGLTIASSLAKMMGGELtlFSTPGVGS-CFSLVLPLNE 616
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
280-499 |
2.56e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 77.90 E-value: 2.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 280 LITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHdEYTRIAFAKSEQLKNLIEDLFEYTKLTNeqvvLEKQEVCVNELLE 359
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAH-QLAQVMAKEADRLNRVVSELLELVKPTH----LALQAVDLNDLIN 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 360 QLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTR 439
Cdd:PRK10364 315 HSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAA 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446641859 440 EELANLFERFYKKDqsrsrvTEGSGLGLAIAKSIVELQGGSIRAEYRDGT-IQFIVSLPII 499
Cdd:PRK10364 395 DQLEAIFTPYFTTK------AEGTGLGLAVVHNIVEQHGGTIQVASQEGKgATFTLWLPVN 449
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
274-339 |
5.01e-15 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 69.55 E-value: 5.01e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446641859 274 EKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQhDEYTRIAFAKSEQLKNLIEDLFEYTK 339
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQ-REYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
394-497 |
8.79e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 70.29 E-value: 8.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSKDD-GEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKS 472
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 446641859 473 IVELQGGSIRAEYRDGTIQ-----FIVSLP 497
Cdd:cd16953 81 IIEAHGGISVAENHNQPGQvigarFTVQLP 110
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
394-488 |
8.96e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 70.51 E-value: 8.96e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRvfdNLLMNAIKYSKDDGEIKVSLQRQRRDiQIVIANHSEEFTREELANLFERFYKKDqsrSRVTEGSGLGLAIAKSI 473
Cdd:cd16940 17 LLR---NLVDNAVRYSPQGSRVEIKLSADDGA-VIRVEDNGPGIDEEELEALFERFYRSD---GQNYGGSGLGLSIVKRI 89
|
90
....*....|....*
gi 446641859 474 VELQGGSIRAEYRDG 488
Cdd:cd16940 90 VELHGGQIFLGNAQG 104
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
276-343 |
9.15e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 68.78 E-value: 9.15e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446641859 276 QKNELITNVSHDLRTPLTSIMGYLRLLRDSKyeNKEQHDEYTRIAFAKSEQLKNLIEDLFEYTKLTNE 343
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEK--LDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
259-498 |
4.94e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 74.38 E-value: 4.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 259 MAEELMNNIEKERKLekqkNELITNVSHDLRTPLTSIMGYLRLLRdskyENKEQHDEYTRIAFAKSEQLKNLIEDLFEYT 338
Cdd:COG5805 273 EAEELMARSEKLSIA----GQLAAGIAHEIRNPLTSIKGFLQLLQ----PGIEDKEEYFDIMLSELDRIESIISEFLALA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 339 KLTNEQvvleKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVS 418
Cdd:COG5805 345 KPQAVN----KEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIH 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 419 LQRQRRDIQIVIANHSEEFTREELANLFERFYkkdqsrSRVTEGSGLGLAIAKSIVELQGGSIRAEYRDGT-IQFIVSLP 497
Cdd:COG5805 421 TEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKgTTFTITLP 494
|
.
gi 446641859 498 I 498
Cdd:COG5805 495 L 495
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
398-474 |
5.29e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 68.00 E-value: 5.29e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446641859 398 FDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIV 474
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVM 81
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
276-343 |
3.85e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 64.12 E-value: 3.85e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446641859 276 QKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQhdEYTRIAFAKSEQLKNLIEDLFEYTKLTNE 343
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
201-481 |
2.58e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 69.49 E-value: 2.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 201 LIGVLVFIFSFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAALTENINNMA-------EELMNNIE----- 268
Cdd:PRK11107 185 LLGIGLALLFAFRLMRDVTGPIRNMVNTVDRIRRGQLDSRVEGNMLGELDMLKNGINAMAmslsayhEEMQQNIDqatsd 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 269 ------------------KERKLE--KQKNELITNVSHDLRTPLTSIMGYLRLLRdsKYE-NKEQHDEYTRIAfaKS-EQ 326
Cdd:PRK11107 265 lretleqmeiqnveldlaKKRAQEaaRIKSEFLANMSHELRTPLNGVIGFTRQTL--KTPlTPTQRDYLQTIE--RSaNN 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 327 LKNLIEDLFEYTKLTNEQVVLEK---------QEVCVnelleqlieELVPQAEEHGLTFV----KKFPEeraYASIDSEK 393
Cdd:PRK11107 341 LLAIINDILDFSKLEAGKLVLENipfslretlDEVVT---------LLAHSAHEKGLELTlnidPDVPD---NVIGDPLR 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSkDDGEIKVSLQ-----RQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLA 468
Cdd:PRK11107 409 LQQIITNLVGNAIKFT-ESGNIDILVElralsNTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLV 487
|
330
....*....|...
gi 446641859 469 IAKSIVELQGGSI 481
Cdd:PRK11107 488 ITQKLVNEMGGDI 500
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
400-488 |
3.74e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.86 E-value: 3.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 400 NLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYK----KDQSRSrvtegSGLGLAIAKSIVE 475
Cdd:cd16945 11 NLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprpHSGQKS-----TGLGLAFVQEVAQ 85
|
90
....*....|...
gi 446641859 476 LQGGSIRAEYRDG 488
Cdd:cd16945 86 LHGGRITLRNRPD 98
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
200-482 |
5.19e-12 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 68.17 E-value: 5.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 200 FLIGVLVFIF-SFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAAL-------TENINNMAEELMNNIEKER 271
Cdd:COG4192 332 ALLSLLLAVLiNYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIarllrvfRDQAIEKTQELETEIEERK 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 272 KLEKQ----KNELI------------TNVSHDLRTPLTSIMGYLRLLRDS-KYENKEQHDEYTRIAFAKSEQLKNLIEDL 334
Cdd:COG4192 412 RIEKNlrqtQDELIqaakmavvgqtmTSLAHELNQPLNAMSMYLFSAKKAlEQENYAQLPTSLDKIEGLIERMDKIIKSL 491
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 335 FEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQaeehglTFVKKFPEErAYASIDSEKMVRVFDNLLMNAIKYSKDDGE 414
Cdd:COG4192 492 RQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQ------QITLHIPDD-LMVQGDQVLLEQVLVNLLVNALDAVATQPQ 564
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446641859 415 IKVSLQRQRRDIQIVIANHSEEFtrEELANLFERFYkkdqsrSRVTEGSGLGLAIAKSIVELQGGSIR 482
Cdd:COG4192 565 ISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLY 624
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
368-498 |
8.78e-12 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 66.80 E-value: 8.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 368 QAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAI----KYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELA 443
Cdd:COG3290 256 RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLE 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446641859 444 NLFER-FYKKDQsrsrvtEGSGLGLAIAKSIVELQGGSIRAEYRDGT-IQFIVSLPI 498
Cdd:COG3290 336 KIFERgFSTKLG------EGRGLGLALVKQIVEKYGGTIEVESEEGEgTVFTVRLPK 386
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
390-484 |
1.04e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 61.32 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 390 DSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRsRVTEGSGLGLAI 469
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90
....*....|....*
gi 446641859 470 AKSIVELQGGSIRAE 484
Cdd:cd16975 80 AKNLVEKHGGSLIIE 94
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
394-488 |
1.19e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 61.31 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSKddGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvTEGSGLGLAIAKSI 473
Cdd:cd16950 1 LKRVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90
....*....|....*
gi 446641859 474 VELQGGSIRAEYRDG 488
Cdd:cd16950 77 SDAHGGSLTLANRAG 91
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
394-497 |
3.40e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 59.75 E-value: 3.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSkdDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSI 473
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 446641859 474 VELQGGSIRAEYRD-GTIQFIVSLP 497
Cdd:cd16939 79 ALWHGGHVECDDSElGGACFRLTWP 103
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
133-501 |
1.66e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 63.11 E-value: 1.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 133 QIDLHNTIRNAASFAINYTDGRNVFESTRKEFISFSPITIEGKNLYMFVSGIPEGEVIYDTQE----GPFPFLIGVLVFI 208
Cdd:COG2972 92 LLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSlrrlILLIILLLLLLAL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 209 FSFFYITKRKMKQIEAMAQGVKEIERGNLAyRIEKKGEDEIAALTENINNMAEELMNNIEKERKLEKQKN--ELITNVS- 285
Cdd:COG2972 172 LLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKeaELKALQAq 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 286 ---HDLRTPLTSImgylrllrdskyenkeqhdeYTRIAFAKSEQLKNLIEDL---FEYTKLTNEQVVLEKQEVcvnelle 359
Cdd:COG2972 251 inpHFLFNTLNSI--------------------RWLAELEDPEEAEEMLEALsklLRYSLSKGDELVTLEEEL------- 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 360 qlieelvpqaeEH--------------GLTFVKKFPEErayasIDSEKMVRvfdnLLM-----NAIKY----SKDDGEIK 416
Cdd:COG2972 304 -----------ELiksyleiqklrfgdRLEVEIEIDEE-----LLDLLIPK----LILqplveNAIEHgiepKEGGGTIR 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 417 VSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDqsrsrvtEGSGLGLAIAKSIVELQ-----GGSIRAEYRDGTIQ 491
Cdd:COG2972 364 ISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKG-------EGRGIGLRNVRERLKLYygeeyGLEIESEPGEGTTV 436
|
410
....*....|
gi 446641859 492 fIVSLPIIEK 501
Cdd:COG2972 437 -TIRIPLEEE 445
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
284-498 |
4.37e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 62.30 E-value: 4.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 284 VSHDLRTPLTSIMGYLRLLRdskyeNKEQHDEYTRIAFA---KSEQLKNLIEDLFEYTKLTNEQVVLEKQEVCVNELLEQ 360
Cdd:PRK10841 454 VSHELRTPLYGIIGNLDLLQ-----TKELPKGVDRLVTAmnnSSSLLLKIISDILDFSKIESEQLKIEPREFSPREVINH 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 361 LIEELVPQAeehgltfVKK------FPEERAYASIDSEKM--VRVFDNLLMNAIKYSkDDGEIKVSLQRQRRDIQIVIAN 432
Cdd:PRK10841 529 ITANYLPLV-------VKKrlglycFIEPDVPVALNGDPMrlQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRD 600
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446641859 433 HSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSIRAEYRDGT-IQFIVSLPI 498
Cdd:PRK10841 601 TGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMgSQFTIRIPL 667
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
219-263 |
1.53e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 53.22 E-value: 1.53e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446641859 219 MKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAALTENINNMAEEL 263
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
394-497 |
4.23e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 53.94 E-value: 4.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSKD-DGEI----------KVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKkdqsrSRVtEG 462
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIilrtrtqrqvTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVS-----GRE-NG 74
|
90 100 110
....*....|....*....|....*....|....*
gi 446641859 463 SGLGLAIAKSIVELQGGSIRAEYRDGTIQFIVSLP 497
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
394-497 |
4.37e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 53.87 E-value: 4.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRVFDNLLMNAIKYSKDD--GEIKVSLQRQR-------RDIQIVIanhSEEFTrEELANLFERFYKKDQSrsrvtEGSG 464
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGeewtfyvRDNGIGI---DPEYA-EKVFGIFQRLHSREEY-----EGTG 71
|
90 100 110
....*....|....*....|....*....|....*
gi 446641859 465 LGLAIAKSIVELQGGSIRAE--YRDGTiQFIVSLP 497
Cdd:cd16921 72 VGLAIVRKIIERHGGRIWLEsePGEGT-TFYFTLP 105
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
200-500 |
4.48e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 58.74 E-value: 4.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 200 FLIGVLVFIFSFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAALTENINNMAEELMnniEKERKLEKQKNE 279
Cdd:COG3850 124 LLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQ---ELYAELEEEEEL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 280 LITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHDEYTRIAFAKSEQLKNLIEDLFEYTKLTNEQVVLEKQEVCVNELLE 359
Cdd:COG3850 201 EAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 360 QLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTR 439
Cdd:COG3850 281 LELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGA 360
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446641859 440 EELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSIRAEYRDGTIQFIVSLPIIE 500
Cdd:COG3850 361 ALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIV 421
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
9-501 |
4.61e-09 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 58.97 E-value: 4.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 9 TYIRKIRELFEKLVKSVRKSIRIQLITTFAACALLGVLSAKAAAPFFENANRQATIDYRAGMEQINHQAQGAANSSVHEN 88
Cdd:COG2770 28 LALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 89 KLEAISNMIEMENQNLEQGSRALKILVTDESGKVLYKTKQAQEEQIDLHNTIRNAASFAINYTDGRNVFESTRKEFISFS 168
Cdd:COG2770 108 ALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 169 PITIEGKNLYMFVSGIPEgEVIYDTQEGPFPFLIGVLVFIFSFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDE 248
Cdd:COG2770 188 AALLLLLLGGLLLVVLLE-AALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDE 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 249 IAALTENINNMAEELMNNIEKERKLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENKEQHDEYTRIAFAKSEQLK 328
Cdd:COG2770 267 IGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLL 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 329 NLIEDLFEYTKLTNEQVVLEKQEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKY 408
Cdd:COG2770 347 AADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAA 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 409 SKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRVTEGSGLGLAIAKSIVELQGGSIRAEYRDG 488
Cdd:COG2770 427 AAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELA 506
|
490
....*....|...
gi 446641859 489 TIQFIVSLPIIEK 501
Cdd:COG2770 507 EELLLLEGLLLLL 519
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
247-486 |
6.35e-09 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 57.67 E-value: 6.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 247 DEIAALTENINNMAEELMNNIEKERklekqkneLIT-NVSHDLRTPLTSIMGYLRLLrdskyenKEQHDEYTRIAFAKSE 325
Cdd:PRK10755 114 LEIEAVTSALNQLVSRLTSTLDQER--------LFTaDVAHELRTPLAGIRLHLELL-------EKQHHIDVAPLIARLD 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 326 QLKNLIEDLFEYTKLTNEQVVLEKQEVC-VNELLEQLIEELVPQAEEHGLTFVKKFPEERAYASIDS---EKMVRvfdNL 401
Cdd:PRK10755 179 QMMHTVEQLLQLARAGQSFSSGHYQTVKlLEDVILPSQDELSEMLEQRQQTLLLPESAADITVQGDAtllRLLLR---NL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 402 LMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHS---EEFTREELANLFERFykkDQSRSrvteGSGLGLAIAKSIVELQG 478
Cdd:PRK10755 256 VENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGpgiDESKCGELSKAFVRM---DSRYG----GIGLGLSIVSRITQLHH 328
|
....*...
gi 446641859 479 GSIRAEYR 486
Cdd:PRK10755 329 GQFFLQNR 336
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
396-498 |
1.12e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 52.81 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 396 RVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYkkdqSRSRVTEGSGLGLAIAKSIVE 475
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF----TTKPVGEGTGLGLSLSYRIIQ 81
|
90 100
....*....|....*....|....
gi 446641859 476 LQGGSIRAEYRDGT-IQFIVSLPI 498
Cdd:cd16943 82 KHGGTIRVASVPGGgTRFTIILPI 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
397-497 |
3.77e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 51.24 E-value: 3.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 397 VFDNLLMNAIK----YSKDDGEIKVSLQR-QRRDIQIVIANHSEEFTREELANLFERFYkkdqsrSRVTEGSGLGLAIAK 471
Cdd:cd16920 4 VLINLVRNGIEamseGGCERRELTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICR 77
|
90 100
....*....|....*....|....*...
gi 446641859 472 SIVELQGGSIRAEYRD--GTIqFIVSLP 497
Cdd:cd16920 78 SIIEAHGGRLSVESPAggGAT-FQFTLP 104
|
|
| HAMP |
pfam00672 |
HAMP domain; |
214-263 |
6.29e-08 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 49.16 E-value: 6.29e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 446641859 214 ITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAALTENINNMAEEL 263
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
390-488 |
1.66e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 49.46 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 390 DSEKMVRVFDNLLMNA---IKYSKDD---GEIKVSLQRQRRdIQIVIANHSEEFTREELANLFERfYKKDQSRsrvteGS 463
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSDvgeVRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100
....*....|....*....|....*
gi 446641859 464 GLGLAIAKSIVELQGGSIRAEYRDG 488
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREA 98
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
394-496 |
3.35e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 52.73 E-value: 3.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 394 MVRvfdNLLMNAIKYSKDDGEIKVSLQRQRrdiqIVIANHSEEFTREELANLFERFYKK-DQSRSrvteGSGLGLAIAKS 472
Cdd:PRK10337 356 LVR---NLLDNAIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERFYRPpGQEAT----GSGLGLSIVRR 424
|
90 100
....*....|....*....|....*
gi 446641859 473 IVELQGGSIR-AEYRDGTiqFIVSL 496
Cdd:PRK10337 425 IAKLHGMNVSfGNAPEGG--FEAKV 447
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
389-484 |
4.16e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 49.17 E-value: 4.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 389 IDSEKMVRVFDNLLMNAIKYSkdDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSrvteGSGLGLA 468
Cdd:cd16954 33 GERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLA 106
|
90
....*....|....*.
gi 446641859 469 IAKSIVELQGGSIRAE 484
Cdd:cd16954 107 IAKEIVEQYGGELSLS 122
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
219-263 |
4.57e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 46.47 E-value: 4.57e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446641859 219 MKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAALTENINNMAEEL 263
Cdd:smart00304 4 LRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRL 48
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
390-492 |
6.39e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 48.05 E-value: 6.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 390 DSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRsRVTEGSGLGLAI 469
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*...
gi 446641859 470 AKSIVELQGGSIRAEYRDG-----TIQF 492
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGegttfTITF 108
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
397-482 |
7.40e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 47.45 E-value: 7.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 397 VFDNLLMNAIK--YSKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYkkdqSRSRVTEGSGLGLAIAKSIV 474
Cdd:cd16976 4 VLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF----TTKPVGKGTGLGLSISYGIV 79
|
....*...
gi 446641859 475 ELQGGSIR 482
Cdd:cd16976 80 EEHGGRLS 87
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
41-263 |
9.59e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 51.17 E-value: 9.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 41 ALLGVLSAKAAAPFFENANRQATIDYRAGMEQINHQAQGAANSSVHENKLEAISNMIEMENQNLEQGSRALKILVTDESG 120
Cdd:COG0840 29 LLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 121 KVLYKTKQAQEEQIDLHNTIRNAASFAINYTDGRNVFESTRKEFISFSPITIEGKNLYMFVSGIPEGEVIYDTQEGPFPF 200
Cdd:COG0840 109 LAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAAL 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446641859 201 LIGVLVFIFSFFYITKRKMKQIEAMAQGVKEIERGNLAYRIEKKGEDEIAALTENINNMAEEL 263
Cdd:COG0840 189 LALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
201-317 |
1.76e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 50.44 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 201 LIGVLVFIFSFFYITKRKM---KQIEAMAQGvkeIERGNLAYRIEKKGEDEIAALTENINNMAEEL--MNNIEKERKLEK 275
Cdd:PRK10600 132 VFMALLLVFTIIWLRRRLLqpwRQLLSMANA---VSHRDFTQRANISGRDEMAMLGTALNNMSAELaeSYAVLEQRVQEK 208
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446641859 276 -----QKNE-----------LITNVSHDLR-----------TPLTSIMgylrlLRDSKYENKEQHDEYT 317
Cdd:PRK10600 209 tagleQKNQilsflwqanrrLHSRAPLCERlspvlnglqnlTLLRDIE-----LRVYETDDEENHQEFT 272
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-496 |
6.98e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 45.65 E-value: 6.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 368 QAEEHGLTFVKKFPEERAyASIDSEKMVRVFDNLLMNAI----KYSKDDGEIKVSLQRQRRDIQIVIANHSEEftreELA 443
Cdd:cd16935 12 LAREKGIEFTIEIDIPIL-LPISPLDLCIIFGNLLDNAIeacaKIDKENRFIHLKIRQKKGFLIISIENSYEG----ELK 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446641859 444 NLFERFY--KKDQSRsrvtegsGLGLAIAKSIVELQGGSIRAEYRDGTIQFIVSL 496
Cdd:cd16935 87 KKNGLFLstKKDKNH-------GIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
373-501 |
8.54e-06 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 48.52 E-value: 8.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 373 GLTFVKKFPEERAYASIDSEKMVRVFDNLLMNAIKYSKDDGEIKVSLQRQ---------------RRDIQIVIANHSEEF 437
Cdd:PRK13837 540 GVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAklrapkvlshgvlppGRYVLLRVSDTGAGI 619
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446641859 438 TREELANLFERFYKkdqSRSRvteGSGLGLAIAKSIVELQGGSI--RAEYRDGTiQFIVSLPIIEK 501
Cdd:PRK13837 620 DEAVLPHIFEPFFT---TRAG---GTGLGLATVHGIVSAHAGYIdvQSTVGRGT-RFDVYLPPSSK 678
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
272-483 |
1.07e-05 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 48.36 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 272 KLEKQKNELITNVSHDLRTPLTSIMGYLRLLRDSKYENkeQHDEYTRIAFAKSEQLKNLIEDLFEYTKLT--NEQVVLEK 349
Cdd:PRK11466 439 KASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALN--AQRDDLRAITDSGESLLTILNDILDYSAIEagGKNVSVSD 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 350 QEVCVNELLEQLIEELVPQAEEHGLTFVKKFPEE-RAYASIDSEKMVRVFDNLLMNAIKYSkDDGEIKVSLQRQRRDIQI 428
Cdd:PRK11466 517 EPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLV 595
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446641859 429 VIANHSEEFTREELANLFERFYKKDQSRSrvteGSGLGLAIAKSIVELQGGSIRA 483
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKRG----GTGLGLTISSRLAQAMGGELSA 646
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
395-496 |
2.94e-05 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 42.97 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 395 VRVFDNLLMNAI---KYSKDDGEIKVSLQRQRRDIQIVIANHSEEftreELanlfeRFYKKDQSRSRVTEGSGLGLAIAK 471
Cdd:pfam14501 7 CVIFGNLLDNAIeacSKIDDNRFIRLKIREKQNFLIIRIENTYEG----EL-----KFEGKLPSTKTKGDGHGIGLKSIR 77
|
90 100
....*....|....*....|....*
gi 446641859 472 SIVELQGGSIRAEYRDGTIQFIVSL 496
Cdd:pfam14501 78 RIVKKYGGNLSTEIENGIFTLSILL 102
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
389-497 |
8.93e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 44.90 E-value: 8.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 389 IDSEKMVR----VFDNLLMNAIKY--SKDDGEIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYkkdqsrSRVTEG 462
Cdd:PRK11086 425 SGDEDQVHelitILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSN 498
|
90 100 110
....*....|....*....|....*....|....*.
gi 446641859 463 SGLGLAIAKSIVELQGGSIRAEYRDGT-IQFIVSLP 497
Cdd:PRK11086 499 RGVGLYLVKQSVENLGGSIAVESEPGVgTQFFVQIP 534
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
222-484 |
2.18e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 43.85 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 222 IEAMAQGVKEIERGNlayRiEKKGED---EIAALTENINnmaeELMNNiEKERkLEKQKNELiTNVSHDLRTPLTSIMGY 298
Cdd:PRK10815 219 IEALAKQVRELEEGE---R-EQLDPNpprELTSLVRNLN----RLLKN-ERER-YTKYRTTL-TDLTHSLKTPLAVLQST 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 299 LRLLRDSKYENKEQH-----DEYTRI----------AFAKSEQ-------------LKNLIEDLfeyTKltneqvVLEKQ 350
Cdd:PRK10815 288 LRSLRSGKQMSVEQAepimlEQISRIsqqigyylhrASMRSEHnllsrelhsvaplLDNLTSAL---NK------VYQRK 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 351 EVCVNELLEqlieelvPQaeehgLTFVkkfpeerayasidSEK--MVRVFDNLLMNAIKYSKDDGEIKVslqRQRRD-IQ 427
Cdd:PRK10815 359 GVNITLDIS-------PE-----ITFV-------------GEKndFMEVMGNVLDNACKYCLEFVEISA---RQTDEhLH 410
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 446641859 428 IVIANHSEEFTREELANLFERFYKKDQSRSrvteGSGLGLAIAKSIVELQGGSIRAE 484
Cdd:PRK10815 411 IVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAG 463
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
401-500 |
2.77e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 43.36 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 401 LLMNAIKY---SKDDGEIKVSLQRQRRDIQIVIANH----SEEFTREElanlferfykkdqsrsrvteGSGLGLAIAKSI 473
Cdd:COG3920 407 LVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNgvglPEDVDPPA--------------------RKGLGLRLIRAL 466
|
90 100
....*....|....*....|....*..
gi 446641859 474 VELQGGSIRAEYRDGTiQFIVSLPIIE 500
Cdd:COG3920 467 VRQLGGTLELDRPEGT-RVRITFPLAE 492
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
400-497 |
5.26e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 36.50 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446641859 400 NLLMNAIKYSKDDG----EIKVSLQRQRRDIQIVIANHSEEFTREELANLFERFYKKDQSRSRvtegsGLGLAIAKSIVE 475
Cdd:cd16915 7 NLIDNALDALAATGapnkQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|....
gi 446641859 476 LQGGSIRAE--YRDGTiQFIVSLP 497
Cdd:cd16915 82 RLGGSITVEsePGGGT-TFSIRIP 104
|
|
| |
