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Conserved domains on  [gi|446646239|ref|WP_000723585|]
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MULTISPECIES: sensor histidine kinase [Bacillus]

Protein Classification

sensor histidine kinase( domain architecture ID 11468388)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals, such as Bacillus subtilis thermosensor DesK which regulates the order of membrane lipids by controlling the expression of the gene encoding delta 5-acyl-lipid desaturase, oxygen sensor histidine kinase NreB which is involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen, sensor histidine kinase LiaS which is involved in sensing cell wall stress, and Staphylococcus aureus VraS which positively modulates cell wall biosynthesis

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10500846|10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
146-399 1.29e-55

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 183.67  E-value: 1.29e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 146 LAILISMFLLVLAIIIPFSYINKQQFDARnriqsyiQELESAYMRVEELTLANERQRMARDLHDTLAQGVASLIMQLEAI 225
Cdd:COG4585    7 LGALALLVGALLGLLLALVLLRARRAERA-------AELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 226 dAHMQKGNTVRSQEIMKQTMIRARQTLHDARLVIDDLRHTTN---SFNKAVEEEVQRFSEATSIHVRFTIQ-SPPHISSL 301
Cdd:COG4585   80 -RRLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALddlGLAAALEELAERLLRAAGIRVELDVDgDPDRLPPE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 302 VKEHCLYVISECLTNIAKHSQATEVNLKVEYIDDleKLTIEVEDNGIGFDTGDIGknPGHYGLIGLNERVRLMNGEIHIL 381
Cdd:COG4585  159 VELALYRIVQEALTNALKHAGATRVTVTLEVDDG--ELTLTVRDDGVGFDPEAAP--GGGLGLRGMRERAEALGGTLTIG 234

                        250
                 ....*....|....*...
gi 446646239 382 SEKMKGTKVYIQVPINNE 399
Cdd:COG4585  235 SAPGGGTRVRATLPLAAA 252
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
146-399 1.29e-55

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 183.67  E-value: 1.29e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 146 LAILISMFLLVLAIIIPFSYINKQQFDARnriqsyiQELESAYMRVEELTLANERQRMARDLHDTLAQGVASLIMQLEAI 225
Cdd:COG4585    7 LGALALLVGALLGLLLALVLLRARRAERA-------AELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 226 dAHMQKGNTVRSQEIMKQTMIRARQTLHDARLVIDDLRHTTN---SFNKAVEEEVQRFSEATSIHVRFTIQ-SPPHISSL 301
Cdd:COG4585   80 -RRLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALddlGLAAALEELAERLLRAAGIRVELDVDgDPDRLPPE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 302 VKEHCLYVISECLTNIAKHSQATEVNLKVEYIDDleKLTIEVEDNGIGFDTGDIGknPGHYGLIGLNERVRLMNGEIHIL 381
Cdd:COG4585  159 VELALYRIVQEALTNALKHAGATRVTVTLEVDDG--ELTLTVRDDGVGFDPEAAP--GGGLGLRGMRERAEALGGTLTIG 234

                        250
                 ....*....|....*...
gi 446646239 382 SEKMKGTKVYIQVPINNE 399
Cdd:COG4585  235 SAPGGGTRVRATLPLAAA 252
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-395 2.34e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 93.00  E-value: 2.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 306 CLYVISECLTNIAKHSQATEVNLKVEYIDDleKLTIEVEDNGIGFDtGDIGKNPGHYGLIGLNERVRLMNGEIHILSEKM 385
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTAD--ELTLTVVDDGVGFD-GPAPPGGGGFGLLGMRERAELLGGTLTIGSRPG 77

                         90
                 ....*....|
gi 446646239 386 KGTKVYIQVP 395
Cdd:cd16917   78 GGTRVTARLP 87
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
184-404 3.84e-20

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 92.43  E-value: 3.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 184 LESAYMRVEELTLANERQRMARDLHDTLAQGVASLIMQLEAIdaHMQKGN-TVRSQEIMKQtmIRA---------RQTLH 253
Cdd:PRK10600 346 LERQQERQQQLIVMEERATIARELHDSIAQSLSCMKMQVSCL--QMQGDAlPESSRELLSQ--IRNelnaswrqlRELLT 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 254 DARlviddLRHTTNSFNKAVEEEVQRFSEATSIHVRFTIQSPPH-ISSLVKEHCLYVISECLTNIAKHSQATEVNLKVEY 332
Cdd:PRK10600 422 TFR-----LQLTEPGLRPALEASCEEFSARFGFPVKLDYQLPPRlVPSHQAIHLLQIAREALSNALKHAQASEVVVTVAQ 496

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446646239 333 IDDLEKLTieVEDNGIGFdtGDIGKNPGHYGLIGLNERVRLMNGEIHILSEKMKGTKVYIQV-----PINNEGDSHE 404
Cdd:PRK10600 497 NQNQVKLS--VQDNGCGV--PENAERSNHYGLIIMRDRAQSLRGDCRVRRRESGGTEVVVTFipektFTDVQGDTHE 569
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 199-266 3.56e-14

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 66.88  E-value: 3.56e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446646239  199 ERQRMARDLHDTLAQGVASLIMQLEAIDAHMQKGNTvRSQEIMKQTMIRARQTLHDARLVIDDLRHTT 266
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDPE-EAREQLDAIRELAREALQELRRLLGDLRPPA 67
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 309-396 2.07e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.36  E-value: 2.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239   309 VISECLTNIAKHSQAtEVNLKVEYIDDLEKLTIEVEDNGIGFD-------------TGDIGKNPGHYGLiGL---NERVR 372
Cdd:smart00387   9 VLSNLLDNAIKYTPE-GGRITVTLERDGDHVEITVEDNGPGIPpedlekifepffrTDKRSRKIGGTGL-GLsivKKLVE 86

                           90       100
                   ....*....|....*....|....
gi 446646239   373 LMNGEIHILSEKMKGTKVYIQVPI 396
Cdd:smart00387  87 LHGGEISVESEPGGGTTFTITLPL 110
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
146-399 1.29e-55

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 183.67  E-value: 1.29e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 146 LAILISMFLLVLAIIIPFSYINKQQFDARnriqsyiQELESAYMRVEELTLANERQRMARDLHDTLAQGVASLIMQLEAI 225
Cdd:COG4585    7 LGALALLVGALLGLLLALVLLRARRAERA-------AELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 226 dAHMQKGNTVRSQEIMKQTMIRARQTLHDARLVIDDLRHTTN---SFNKAVEEEVQRFSEATSIHVRFTIQ-SPPHISSL 301
Cdd:COG4585   80 -RRLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPALddlGLAAALEELAERLLRAAGIRVELDVDgDPDRLPPE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 302 VKEHCLYVISECLTNIAKHSQATEVNLKVEYIDDleKLTIEVEDNGIGFDTGDIGknPGHYGLIGLNERVRLMNGEIHIL 381
Cdd:COG4585  159 VELALYRIVQEALTNALKHAGATRVTVTLEVDDG--ELTLTVRDDGVGFDPEAAP--GGGLGLRGMRERAEALGGTLTIG 234

                        250
                 ....*....|....*...
gi 446646239 382 SEKMKGTKVYIQVPINNE 399
Cdd:COG4585  235 SAPGGGTRVRATLPLAAA 252
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-395 2.34e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 93.00  E-value: 2.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 306 CLYVISECLTNIAKHSQATEVNLKVEYIDDleKLTIEVEDNGIGFDtGDIGKNPGHYGLIGLNERVRLMNGEIHILSEKM 385
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTAD--ELTLTVVDDGVGFD-GPAPPGGGGFGLLGMRERAELLGGTLTIGSRPG 77

                         90
                 ....*....|
gi 446646239 386 KGTKVYIQVP 395
Cdd:cd16917   78 GGTRVTARLP 87
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
184-404 3.84e-20

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 92.43  E-value: 3.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 184 LESAYMRVEELTLANERQRMARDLHDTLAQGVASLIMQLEAIdaHMQKGN-TVRSQEIMKQtmIRA---------RQTLH 253
Cdd:PRK10600 346 LERQQERQQQLIVMEERATIARELHDSIAQSLSCMKMQVSCL--QMQGDAlPESSRELLSQ--IRNelnaswrqlRELLT 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 254 DARlviddLRHTTNSFNKAVEEEVQRFSEATSIHVRFTIQSPPH-ISSLVKEHCLYVISECLTNIAKHSQATEVNLKVEY 332
Cdd:PRK10600 422 TFR-----LQLTEPGLRPALEASCEEFSARFGFPVKLDYQLPPRlVPSHQAIHLLQIAREALSNALKHAQASEVVVTVAQ 496

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446646239 333 IDDLEKLTieVEDNGIGFdtGDIGKNPGHYGLIGLNERVRLMNGEIHILSEKMKGTKVYIQV-----PINNEGDSHE 404
Cdd:PRK10600 497 NQNQVKLS--VQDNGCGV--PENAERSNHYGLIIMRDRAQSLRGDCRVRRRESGGTEVVVTFipektFTDVQGDTHE 569
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 189-395 7.03e-20

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 91.22  E-value: 7.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 189 MRVEEltlaNERQRMARDLHDTLAQGV------ASLIMQLEAIDAHMQKGNTVRSQ-EIMKQTMiraRQTLHDAR-LVID 260
Cdd:COG3851  286 VSAEE----SERREIARELHDEIGQNItairtqASILKRLAPQPEIEQSAQSIESLaLRIYDTT---RRLLDRLRpAVLD 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 261 DLrhttnSFNKAVEEEVQRFS-EATSIHVRFTIQSPP----HISSLVkehcLY-VISECLTNIAKHSQATEVNLKVeYID 334
Cdd:COG3851  359 EL-----GLEEALRELPRELAfEEPGISCQLDLRGDPslldDTLQLT----LYrLVQEALTNILKHAEASQIRISL-SQD 428

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446646239 335 DlEKLTIEVEDNGIGFDTGDIGKnpgHYGLIGLNERVRLMNGEIHILSEKmKGTKVYIQVP 395
Cdd:COG3851  429 K-RLLSLEIRDDGIGLPPELRAK---GFGLRGMRERVRALGGDFRLSSAP-KGTRLSVLLP 484
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
173-395 1.59e-16

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 81.18  E-value: 1.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 173 ARNRiqsyiqELESAYMRVEELTlaneRQRMARDLHDTLAQGV------ASLIMQLEAidahmQKGNTVRSQEIMKQTMI 246
Cdd:PRK11644 285 ARNR------HLAERLLETEESV----RRDVARELHDEIGQTItairtqAGIIKRLAA-----DNASVKQSAQLIEQLSL 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 247 RARQTLHD--ARL---VIDDLrhttnSFNKAVEEEVQRFS-EATSIHVRFTIQSPPHISSLVKEHCLY-VISECLTNIAK 319
Cdd:PRK11644 350 GVYDTVRRllGRLrprQLDDL-----TLEQAIRSLMREMElEDRGIVSHLDWRIDESALSETQRVTLFrVCQEGLNNIVK 424

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446646239 320 HSQATEVNLKVEYIDDLEKLTIevEDNGIGFDTGDigkNPGHYGLIGLNERVRLMNGEIHILSEkmKGTKVYIQVP 395
Cdd:PRK11644 425 HADASAVTLQGWQQDERLMLVI--EDDGSGLPPGS---GQQGFGLRGMRERVTALGGTLTISCT--HGTRLSVSLP 493
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
192-395 2.44e-15

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 77.59  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 192 EELTLANERQRMARDLHDTLAQGVASLIMQL----EAIDAHMQKgntvrSQEIMKQTmiraRQTLHDA-----------R 256
Cdd:PRK10935 356 QQLLLMEERATIARELHDSLAQVLSYLKIQLtllkRSLDEDNAK-----AQSIIAEF----DQALSDAyrqlrellttfR 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 257 LVIDDlrhttNSFNKAVEEEVQRFSEATSIHVRFTIQSPPHI---SSLVkeHCLYVISECLTNIAKHSQATEVNLKVEYI 333
Cdd:PRK10935 427 LTIQE-----ANLGSALEEMLDQLRNQTDAKITLDCRLPSQAldaQQQV--HLLQIIREATLNAIKHANASEIAVSCVTN 499

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446646239 334 DDlEKLTIEVEDNGIGFDTGDigKNPGHYGLIGLNERVRLMNGEIHILSEKMKGTKVYIQVP 395
Cdd:PRK10935 500 PD-GEHTVSIRDDGIGIGELK--EPEGHYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFP 558
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 199-266 3.56e-14

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 66.88  E-value: 3.56e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446646239  199 ERQRMARDLHDTLAQGVASLIMQLEAIDAHMQKGNTvRSQEIMKQTMIRARQTLHDARLVIDDLRHTT 266
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDPE-EAREQLDAIRELAREALQELRRLLGDLRPPA 67
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 309-395 4.20e-13

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 65.08  E-value: 4.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239  309 VISECLTNIAKHS-QATEVNLKVEYIDDLeklTIEVEDNGIG------------FDTGDIGKNPGH-YGLIGLNERVRLM 374
Cdd:pfam02518   9 VLSNLLDNALKHAaKAGEITVTLSEGGEL---TLTVEDNGIGippedlprifepFSTADKRGGGGTgLGLSIVRKLVELL 85

                          90       100
                  ....*....|....*....|.
gi 446646239  375 NGEIHILSEKMKGTKVYIQVP 395
Cdd:pfam02518  86 GGTITVESEPGGGTTVTLTLP 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 309-396 2.07e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.36  E-value: 2.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239   309 VISECLTNIAKHSQAtEVNLKVEYIDDLEKLTIEVEDNGIGFD-------------TGDIGKNPGHYGLiGL---NERVR 372
Cdd:smart00387   9 VLSNLLDNAIKYTPE-GGRITVTLERDGDHVEITVEDNGPGIPpedlekifepffrTDKRSRKIGGTGL-GLsivKKLVE 86

                           90       100
                   ....*....|....*....|....
gi 446646239   373 LMNGEIHILSEKMKGTKVYIQVPI 396
Cdd:smart00387  87 LHGGEISVESEPGGGTTFTITLPL 110
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
193-399 5.25e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 59.15  E-value: 5.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 193 ELTLANERQRMARDLHDTLAQGVA--------SLIMQLEAIDAHMQKGNTVRSQ--EIMKQTMIRARQTLHD----ARLV 258
Cdd:COG2205    1 ELEEALEELEELERLKSEFLANVShelrtpltSILGAAELLLDEEDLSPEERREllEIIRESAERLLRLIEDlldlSRLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 259 ID--DLRHTTNSFNKAVEEEVQRFSE-ATSIHVRFTIQSPPHISSLV--KEHCLYVISECLTNIAKHSQA-TEVNLKVEY 332
Cdd:COG2205   81 SGklSLELEPVDLAELLEEAVEELRPlAEEKGIRLELDLPPELPLVYadPELLEQVLANLLDNAIKYSPPgGTITISARR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 333 IDDleKLTIEVEDNGIG------------FDTGDIGKNPGHYGLiGLN---ERVRLMNGEIHILSEKMKGTKVYIQVPIN 397
Cdd:COG2205  161 EGD--GVRISVSDNGPGipeeeleriferFYRGDNSRGEGGTGL-GLAivkRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237


                 ..
gi 446646239 398 NE 399
Cdd:COG2205  238 ES 239
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
79-397 3.82e-08

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 54.53  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239  79 FFVQLFIVFLAAFIVPNASIAIFVGLTPILIAQSLYVYHNIFKVIAVFTLMYAIFCTAISINYGVNKLAILISMFLLVLA 158
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 159 IIIPFSYINKQQFDARNRIQSYIQELESAymrveeltlaneRQRMARDL-HDtLAQGVASLIMQLEAIDAHmQKGNTVRS 237
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEA------------KSRFLANVsHE-LRTPLTAIRGYLELLLEE-LDEEQREY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 238 QEIMKQTMIRARQTLHD----ARL--VIDDLRHTTNSFNKAVEEEVQRFSE-ATSIHVRFTIQSPPHISSLV--KEHCLY 308
Cdd:COG0642  147 LETILRSADRLLRLINDlldlSRLeaGKLELEPEPVDLAELLEEVVELFRPlAEEKGIELELDLPDDLPTVRgdPDRLRQ 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 309 VISECLTNIAKHSQA-TEVNLKVEYIDDleKLTIEVEDNGIG------------FDTGDIGKNPGHYGLiGL---NERVR 372
Cdd:COG0642  227 VLLNLLSNAIKYTPEgGTVTVSVRREGD--RVRISVEDTGPGippedlerifepFFRTDPSRRGGGTGL-GLaivKRIVE 303

                        330       340
                 ....*....|....*....|....*
gi 446646239 373 LMNGEIHILSEKMKGTKVYIQVPIN 397
Cdd:COG0642  304 LHGGTIEVESEPGKGTTFTVTLPLA 328
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 339-395 2.29e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 48.60  E-value: 2.29e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446646239 339 LTIEVEDNGIGFD---TGDIGKNPGHYGLIGL---NERVRLMNGE---IHILSEKMKGTKVYIQVP 395
Cdd:cd16924   38 VMIEVEDNGRGIDpkvLNILGKKPKEGNGIGLynvHQRLILLFGEdygIHIASEPDKGTRITFTIP 103
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
37-399 4.52e-07

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 51.48  E-value: 4.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239  37 MLLEFRNSILSMDSFFFTIVIVIHTVFHWYASSLRNRQLLYFFFVQLFIVFLAAFIVPNASIAIFVGLTPILIAQSLYVY 116
Cdd:COG5002    2 LLLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 117 HNIFKVIAVFTLMYAIfctaISINYGVNKLAILISMFLLVLAIIIPFSYINKQQFDARNRIQSYIQELESAYMRVEELTL 196
Cdd:COG5002   82 ALLLLALLLLLLLLLL----LLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 197 ANERQRMARDL-----HD-----TLAQGVASLIMQLEAIDAHMQKgntvRSQEIMKQTMIRARQTLHD----ARL--VID 260
Cdd:COG5002  158 LERLEQMRREFvanvsHElrtplTSIRGYLELLLDGAADDPEERR----EYLEIILEEAERLSRLVNDlldlSRLesGEL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 261 DLRHTTNSFNKAVEEEVQRFS---EATSIHVRFTIQSPPHISSLVKEHCLYVISECLTNIAKHSQA-TEVNLKVEYIDDl 336
Cdd:COG5002  234 KLEKEPVDLAELLEEVVEELRplaEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEgGTITVSLREEDD- 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 337 eKLTIEVEDNGIGFDTGDIGK--------------NPGHYGLiGLN---ERVRLMNGEIHILSEKMKGTKVYIQVPINNE 399
Cdd:COG5002  313 -QVRISVRDTGIGIPEEDLPRiferfyrvdksrsrETGGTGL-GLAivkHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 338-395 9.84e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 47.07  E-value: 9.84e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446646239 338 KLTIEVEDNGIGFDTGDIGK------NPGHYGLIGLNERVRLMNG-EIHILSEKMKGTKVYIQVP 395
Cdd:cd16955   38 RLHIAVEDNGIGISPKVIERveqdemPGNKIGLLNVHQRLKLGYGeGLHIRSRPDPGTLIAFYIP 102
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
1-399 6.98e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 48.09  E-value: 6.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239   1 MKKINSNIDLDTNVLEAVFIPRRFIVLWITLVYIASMLLEFRNSILSMDSFFFTIVIVIHTVFHWYASSLRNRQLLYFFF 80
Cdd:COG2972   10 IVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239  81 VQLFIVFLAAFIVPNASIAIFVGLTPILIAQSLYVYHNIFKVIAVFTLMYAIFCTAISINYGVNKL-AILISMFLLVLAI 159
Cdd:COG2972   90 LLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLrRLILLIILLLLLL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 160 IIPFSYINKQQFDAR-NRIQSYIQELESAYM-------RVEELTLANERQRMARDLHDTLAQGVASLIMQLEA-IDA-HM 229
Cdd:COG2972  170 ALLLSYLLSRSITRPiKRLKKAMKKVEKGDLvrlevsgNDEIGILARSFNEMVERIKELIEEVYELELEKKEAeLKAlQA 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 230 QKG--------NTVRSQeIMKQTMIRARQTLHDarlVIDDLRHTTNSFNKAV--EEEVQ-----------RFSEatSIHV 288
Cdd:COG2972  250 QINphflfntlNSIRWL-AELEDPEEAEEMLEA---LSKLLRYSLSKGDELVtlEEELEliksyleiqklRFGD--RLEV 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 289 RFTIQspphisslvkEHCLYVISECLT------NIAKH---SQATEVNLKVEYIDDLEKLTIEVEDNGIGFDTGDI---- 355
Cdd:COG2972  324 EIEID----------EELLDLLIPKLIlqplveNAIEHgiePKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLekll 393

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446646239 356 -----GKNPGHYGLIGLNERVRLMNGE---IHILSEKMKGTKVYIQVPINNE 399
Cdd:COG2972  394 eelssKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 325-403 1.20e-05

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 47.22  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 325 EVNLKVEYIDdlEKLTIEVEDNGIGFDTGDI-----------GKNPGhYGLIGLNERVRLMNGEIHILSEKMKGTKVYIQ 393
Cdd:PRK11086 456 EISVSLHYRN--GWLHCEVSDDGPGIAPDEIdaifdkgystkGSNRG-VGLYLVKQSVENLGGSIAVESEPGVGTQFFVQ 532

                         90
                 ....*....|
gi 446646239 394 VPINNEGDSH 403
Cdd:PRK11086 533 IPWDGERSNR 542
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 306-351 3.36e-05

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 42.26  E-value: 3.36e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446646239 306 CLYVISECLTNIAKHSQAT--EVNLKVEYIDDLEKLTIEVEDNGIGFD 351
Cdd:cd16936    1 VELAVSEAVTNAVRHAYRHdgPGPVRLELDLDPDRLRVEVTDSGPGFD 48
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
309-396 3.36e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 42.98  E-value: 3.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 309 VISECLTNIAKHSQA----TEVNLKVEYIDDleKLTIEVEDNGIGFDTGDIGK-----NPGHYGLIGLNervRLMNgEIH 379
Cdd:COG2172   38 AVSEAVTNAVRHAYGgdpdGPVEVELELDPD--GLEIEVRDEGPGFDPEDLPDpystlAEGGRGLFLIR---RLMD-EVE 111

                         90
                 ....*....|....*..
gi 446646239 380 ILSEKmKGTKVYIQVPI 396
Cdd:COG2172  112 YESDP-GGTTVRLVKRL 127
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 325-399 1.36e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 43.68  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 325 EVNLKVEYIDDleKLTIEVEDNGIG---------FDTGDIGKNPGHYGlIGL---NERVRLMNGEIHILSEKMKGTKVYI 392
Cdd:COG3290  306 RVELSIRDDGD--ELVIEVEDSGPGipeellekiFERGFSTKLGEGRG-LGLalvKQIVEKYGGTIEVESEEGEGTVFTV 382


                 ....*..
gi 446646239 393 QVPINNE 399
Cdd:COG3290  383 RLPKEGE 389
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 8-399 8.84e-04

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 41.31  E-value: 8.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239   8 IDLDTNVLEAVFIPRRFIVLWITLVYIASMLLEFRNSILSMDSFFFTIVIVIHTVFHWYASSLRNRQLLYFFFVQLFIVF 87
Cdd:COG4251   92 VLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239  88 LAAFIVPNASIAIFVGLTPILIAQSLYVYHNIFKVIAVFTLMYAIFCTAISINYGVNKLAILISMFLLVLAIIIPFSYIN 167
Cdd:COG4251  172 LAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILV 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 168 KQQFDARNRIQSYIQELESaymRVEELTLAN-ERQRMAR----DLHDTLaQGVASLIMQLEAIDAHMQKGNTVRSQEIMK 242
Cdd:COG4251  252 LELLELRLELEELEEELEE---RTAELERSNeELEQFAYvashDLREPL-RKISGFSQLLEEDYGDKLDEEGREYLERIR 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 243 QTMIRARQTLHD----ARLVIDDLRHTTNSFNKAVEEEVQRFSEA-TSIHVRFTIQSPPHI---SSLVKEhclyVISECL 314
Cdd:COG4251  328 DAAERMQALIDDllaySRVGRQELEFEPVDLNELLEEVLEDLEPRiEERGAEIEVGPLPTVrgdPTLLRQ----VFQNLI 403

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 315 TNIAKHSQATEVN-LKVEYIDDLEKLTIEVEDNGIGFDTGDIGK-------------NPGHyGlIGLN--ER-VRLMNGE 377
Cdd:COG4251  404 SNAIKYSRPGEPPrIEIGAEREGGEWVFSVRDNGIGIDPEYAEKifeifqrlhsrdeYEGT-G-IGLAivKKiVERHGGR 481

                        410       420
                 ....*....|....*....|..
gi 446646239 378 IHILSEKMKGTKVYIQVPINNE 399
Cdd:COG4251  482 IWVESEPGEGATFYFTLPKAPA 503
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 314-405 1.60e-03

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 40.69  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 314 LTNIAKHSQATEVNLKVEYiDDLEKLTIEVEDNGIGFDTGDIGK--------NPGHYGL------IGL---NERVRLMNG 376
Cdd:PRK11091 407 ISNAVKFTQQGGVTVRVRY-EEGDMLTFEVEDSGIGIPEDELDKifamyyqvKDSHGGKpatgtgIGLavsKRLAQAMGG 485

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446646239 377 EIHILSEKMKGT--KVYIQVPINNEGDSHEV 405
Cdd:PRK11091 486 DITVTSEEGKGScfTLTIHAPAVAEEVEDAF 516
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-395 2.59e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 37.78  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446646239 309 VISECLTNIAKH--SQATEVNLKVEYIDDLEKLTIEVEDNGIGFDTGDIGKNPGHYGLIGLNERVRLMNGEIHILSEKMK 386
Cdd:cd16951   43 VVNELLQNALKHafSDREGGTITIRSVVDGDYLRITVIDDGVGLPQDEDWPNKGSLGLQIVRSLVEGELKAFLEVQSAEN 122


                 ....*....
gi 446646239 387 GTKVYIQVP 395
Cdd:cd16951  123 GTRVNIDIP 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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