phospholipase C catayzes the hydroysis of a phosphatidylcholine to form 1,2-diacyl-sn-glycerol and phosphocholine| zinc dependent phospholipase C (PLC) family protein similar to the N-terminal domain PLC domain found in Clostridium perfringens alpha-toxin
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
50-291
9.06e-53
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium.
:
Pssm-ID: 211381 Cd Length: 218 Bit Score: 176.80 E-value: 9.06e-53
soybean trypsin inhibitor (STI)-like domain, beta-trefoil fold; The STI-like domain is found ...
307-363
5.11e-04
soybean trypsin inhibitor (STI)-like domain, beta-trefoil fold; The STI-like domain is found in the soybean trypsin inhibitor (Kunitz) family of protease inhibitors. They inhibit proteases by binding with high affinity to their active sites. Plant Kunitz-type inhibitors are thought to be important in defense, especially against insect pests. The STI-like domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
The actual alignment was detected with superfamily member pfam00197:
Pssm-ID: 472192 Cd Length: 174 Bit Score: 40.75 E-value: 5.11e-04
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
50-291
9.06e-53
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium.
Pssm-ID: 211381 Cd Length: 218 Bit Score: 176.80 E-value: 9.06e-53
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
39-292
1.51e-38
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.
Pssm-ID: 214813 Cd Length: 241 Bit Score: 139.86 E-value: 1.51e-38
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
50-291
9.06e-53
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium.
Pssm-ID: 211381 Cd Length: 218 Bit Score: 176.80 E-value: 9.06e-53
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
39-292
1.51e-38
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.
Pssm-ID: 214813 Cd Length: 241 Bit Score: 139.86 E-value: 1.51e-38
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and ...
54-287
1.62e-09
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.
Pssm-ID: 211380 Cd Length: 238 Bit Score: 58.22 E-value: 1.62e-09
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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