|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
1-268 |
8.77e-134 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 378.68 E-value: 8.77e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 1 MKKLLLTALISTSIFGLAACGGKD-----KDEKKLVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADK 75
Cdd:COG1464 1 MKKLLALLLALALALALAACGSSSaaaaaADKKTIKVGATPGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEALADG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 76 DLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLEPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKD 155
Cdd:COG1464 81 EIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 156 GVDpVSATPKDIADNPKNLKFKtDIEPGLLPQVYNnkEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGD 235
Cdd:COG1464 161 GVG-LLATVKDITENPKNLKFV-ELDAAQLPRSLD--DVDAAVINGNYALEAGLDPTKDALFLEDKDSPYANIIVVREDD 236
|
250 260 270
....*....|....*....|....*....|...
gi 446657732 236 KDKKAIKELVEVLHSKEIEDFITKEYKGAVVPV 268
Cdd:COG1464 237 KDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPA 269
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
29-267 |
1.63e-113 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 326.15 E-value: 1.63e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 29 KLVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLE 108
Cdd:cd13597 1 TLKVGATPVPHAEILEFIKPELKKQGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 109 PIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPvSATPKDIADNPKNLKFKtDIEPGLLPQV 188
Cdd:cd13597 81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGL-TATVKDIVKNPKNLKFK-ELEAAQLPRS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 189 YNNKegDAVLINSNYAIDAKLNPEKDAIAIEG-DDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITKEYKGAVVP 267
Cdd:cd13597 159 LDDV--DAAVINGNYALEAGLNPKKDALALEDkDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
30-268 |
4.35e-102 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 297.25 E-value: 4.35e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 30 LVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLEP 109
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 110 IGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVdPVSATPKDIADNPKNLKFKtDIEPGLLPQVY 189
Cdd:pfam03180 81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGK-GLLATVKDITENPKNLKIK-ELEAAQLPRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446657732 190 NNkeGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITKEYKGAVVPV 268
Cdd:pfam03180 159 DD--VDAAVINTNYALEAGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
4-266 |
2.73e-62 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 197.29 E-value: 2.73e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 4 LLLTALISTSIfgLAACGGKDKDEKKLVVGASNVPHAEILEKAKPLL-EKKGIELEIKKFQDYVLPNKSLADKDLDANYF 82
Cdd:PRK11063 9 AAVGALIGTLA--LVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAkEKYGLDVELVTFNDYVLPNEALSKGDIDANAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 83 QHIPYLEKEIKDKKYDFEIAGKIHLEPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDpVSA 162
Cdd:PRK11063 87 QHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVG-LLP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 163 TPKDIADNPKNLKFkTDIEPGLLPQVYNNKEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIK 242
Cdd:PRK11063 166 TVLDIVENPKNLKI-VELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEDKDSPYVNLIVAREDNKDAENVK 244
|
250 260
....*....|....*....|....
gi 446657732 243 ELVEVLHSKEIEDFITKEYKGAVV 266
Cdd:PRK11063 245 KFVQAYQSDEVYEAANKVFNGGAV 268
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
17-267 |
3.52e-58 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 186.26 E-value: 3.52e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 17 LAACGGKDKDEKKLVVGASNVPHAEILEKAKPLL-EKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDK 95
Cdd:TIGR00363 7 LTGCKQDKKDPLHIKVGVISGAEQQVAEVAAKVAkEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 96 KYDFEIAGKIHLEPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPVSaTPKDIADNPKNLK 175
Cdd:TIGR00363 87 GYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLP-TVLDIVENPKKLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 176 FkTDIEPGLLPQVYNNKEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIED 255
Cdd:TIGR00363 166 I-TELETSQLPRALDDPKVDLAVINTTYAGQVGLNPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEVYQ 244
|
250
....*....|..
gi 446657732 256 FITKEYKGAVVP 267
Cdd:TIGR00363 245 AAQKHFNGGAVK 256
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
1-268 |
8.77e-134 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 378.68 E-value: 8.77e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 1 MKKLLLTALISTSIFGLAACGGKD-----KDEKKLVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADK 75
Cdd:COG1464 1 MKKLLALLLALALALALAACGSSSaaaaaADKKTIKVGATPGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEALADG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 76 DLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLEPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKD 155
Cdd:COG1464 81 EIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 156 GVDpVSATPKDIADNPKNLKFKtDIEPGLLPQVYNnkEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGD 235
Cdd:COG1464 161 GVG-LLATVKDITENPKNLKFV-ELDAAQLPRSLD--DVDAAVINGNYALEAGLDPTKDALFLEDKDSPYANIIVVREDD 236
|
250 260 270
....*....|....*....|....*....|...
gi 446657732 236 KDKKAIKELVEVLHSKEIEDFITKEYKGAVVPV 268
Cdd:COG1464 237 KDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVPA 269
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
29-267 |
1.63e-113 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 326.15 E-value: 1.63e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 29 KLVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLE 108
Cdd:cd13597 1 TLKVGATPVPHAEILEFIKPELKKQGIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 109 PIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPvSATPKDIADNPKNLKFKtDIEPGLLPQV 188
Cdd:cd13597 81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGL-TATVKDIVKNPKNLKFK-ELEAAQLPRS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 189 YNNKegDAVLINSNYAIDAKLNPEKDAIAIEG-DDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITKEYKGAVVP 267
Cdd:cd13597 159 LDDV--DAAVINGNYALEAGLNPKKDALALEDkDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
30-268 |
4.35e-102 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 297.25 E-value: 4.35e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 30 LVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLEP 109
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 110 IGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVdPVSATPKDIADNPKNLKFKtDIEPGLLPQVY 189
Cdd:pfam03180 81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGK-GLLATVKDITENPKNLKIK-ELEAAQLPRAL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446657732 190 NNkeGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITKEYKGAVVPV 268
Cdd:pfam03180 159 DD--VDAAVINTNYALEAGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235
|
|
| PBP2_lipoprotein_MetQ_like |
cd13526 |
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ... |
29-259 |
9.22e-79 |
|
The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270244 Cd Length: 228 Bit Score: 237.60 E-value: 9.22e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 29 KLVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLE 108
Cdd:cd13526 1 KLKIGVTAGPSADVVEAAKKEAKKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 109 PIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPvSATPKDIADNPKNLKFkTDIEPGLLPQV 188
Cdd:cd13526 81 PIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGL-FATVLDITENPKNLEI-VEVDAAQLPRS 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446657732 189 YNnkEGDAVLINSNYAIDAKLNPEKDAIAIE-GDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITK 259
Cdd:cd13526 159 LD--DVDAAVINGNYAISAGLDPRKDAIFLEdSDASPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
|
|
| PBP2_lipoprotein_IlpA_like |
cd13598 |
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ... |
29-259 |
7.54e-78 |
|
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270316 Cd Length: 227 Bit Score: 235.32 E-value: 7.54e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 29 KLVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLE 108
Cdd:cd13598 1 PIKVGVIRGPDAQIWEVVQKVAKEKGLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 109 PIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDpVSATPKDIADNPKNLKFKtDIEPGLLPQV 188
Cdd:cd13598 81 PIGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGVG-LLATVRDIAENPKKLKIV-ELDAGQLPRA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446657732 189 YNnkEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITK 259
Cdd:cd13598 159 LD--DVDLAAINTDYASKAGLTPARDAIAQEDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFALK 227
|
|
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
4-266 |
2.73e-62 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 197.29 E-value: 2.73e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 4 LLLTALISTSIfgLAACGGKDKDEKKLVVGASNVPHAEILEKAKPLL-EKKGIELEIKKFQDYVLPNKSLADKDLDANYF 82
Cdd:PRK11063 9 AAVGALIGTLA--LVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAkEKYGLDVELVTFNDYVLPNEALSKGDIDANAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 83 QHIPYLEKEIKDKKYDFEIAGKIHLEPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDpVSA 162
Cdd:PRK11063 87 QHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVG-LLP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 163 TPKDIADNPKNLKFkTDIEPGLLPQVYNNKEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIK 242
Cdd:PRK11063 166 TVLDIVENPKNLKI-VELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEDKDSPYVNLIVAREDNKDAENVK 244
|
250 260
....*....|....*....|....
gi 446657732 243 ELVEVLHSKEIEDFITKEYKGAVV 266
Cdd:PRK11063 245 KFVQAYQSDEVYEAANKVFNGGAV 268
|
|
| PBP2_lipoprotein_like_1 |
cd13600 |
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ... |
29-259 |
4.06e-60 |
|
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270318 Cd Length: 228 Bit Score: 190.24 E-value: 4.06e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 29 KLVVGASNVPHAEILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLE 108
Cdd:cd13600 1 TLKVATNSGPMTEILEYIAAELAPDGITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPIYHW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 109 PIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPVSATPKDIADNPKNLKFKTdIEPGLLPQV 188
Cdd:cd13600 81 AFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLADIVTNPKNLKFTE-VDLLALPRA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446657732 189 YNnkEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITK 259
Cdd:cd13600 160 LD--DVDLAFGYPSYFDAAGLTPKDGILLEEPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
|
|
| PBP2_lipoprotein_Gna1946 |
cd13599 |
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ... |
29-259 |
3.39e-58 |
|
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270317 Cd Length: 228 Bit Score: 185.29 E-value: 3.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 29 KLVVGASNVPHAEILEKA-KPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHL 107
Cdd:cd13599 1 TIVIGFTPGPYGDMVKNGvAPYLEKKGYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 108 EPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPVSATPKDIADNPKNLKFKTdIEPGLLPQ 187
Cdd:cd13599 81 PPMGLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNIDPLKASVNDIAENPKNIKIVE-LEAAQLPR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446657732 188 VYNnkEGDAVLINSNYAIDAKLNPeKDAIAIEGDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFITK 259
Cdd:cd13599 160 SLD--DVDFAAIQGNFAISSGIKL-TSALALEEMTDPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIHA 228
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
17-267 |
3.52e-58 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 186.26 E-value: 3.52e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 17 LAACGGKDKDEKKLVVGASNVPHAEILEKAKPLL-EKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDK 95
Cdd:TIGR00363 7 LTGCKQDKKDPLHIKVGVISGAEQQVAEVAAKVAkEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 96 KYDFEIAGKIHLEPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPVSaTPKDIADNPKNLK 175
Cdd:TIGR00363 87 GYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLP-TVLDIVENPKKLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 176 FkTDIEPGLLPQVYNNKEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAIKELVEVLHSKEIED 255
Cdd:TIGR00363 166 I-TELETSQLPRALDDPKVDLAVINTTYAGQVGLNPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEVYQ 244
|
250
....*....|..
gi 446657732 256 FITKEYKGAVVP 267
Cdd:TIGR00363 245 AAQKHFNGGAVK 256
|
|
| PBP2_lipoprotein_GmpC |
cd13596 |
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ... |
41-257 |
1.21e-53 |
|
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270314 Cd Length: 230 Bit Score: 173.70 E-value: 1.21e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 41 EILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLEKEIKDKKYDFEIAGKIHLEPIGVYSQKYKSL 120
Cdd:cd13596 12 DIWDKIVEEAEEAGIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGDTVIAPMGIYSKKITSV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 121 KELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDPVSaTPKDIADNPKNLKFkTDIEPGLLPQVYNNKegDAVLIN 200
Cdd:cd13596 92 DELPDGAKIAIPNDPSNLSRALFILQAAGLIKLKKDAGDFP-TVNDITENPKNLEI-VPVDADQVYRALNDV--DAAVIN 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446657732 201 SNYAIDAKLNPEKDAIAIEGDDS----PYANVLVVRKGDKDKKAIKELVEVLHSKEIEDFI 257
Cdd:cd13596 168 NTFALDAGLDPKKDAIFLEDPSSygskPYINLIAVREEDKDNPLYKKLVETYHDERVQKAV 228
|
|
| PRK09861 |
PRK09861 |
lipoprotein NlpA; |
3-267 |
5.64e-53 |
|
lipoprotein NlpA;
Pssm-ID: 182119 Cd Length: 272 Bit Score: 173.28 E-value: 5.64e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 3 KLLLTALISTSIFGLAACGGKDKDEKKLVVGASNVPHAEILEKAKPLL-EKKGIELEIKKFQDYVLPNKSLADKDLDANY 81
Cdd:PRK09861 7 HLRAGAALLLAGILLAGCDQSSSDAKHIKVGVINGAEQDVAEVAKKVAkEKYGLDVELVGFSGSLLPNDATNHGELDANV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 82 FQHIPYLEKEIKDKKYDFEIAGKIHLEPIGVYSQKYKSLKELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDGVDpVS 161
Cdd:PRK09861 87 FQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKG-LL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 162 ATPKDIADNPKNLKFkTDIEPGLLPQVYNNKEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSPYANVLVVRKGDKDKKAI 241
Cdd:PRK09861 166 PTALDITDNPRHLQI-MELEGAQLPRVLDDPKVDVAIISTTYIQQTGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENV 244
|
250 260
....*....|....*....|....*.
gi 446657732 242 KELVEVLHSKEIEDFITKEYKGAVVP 267
Cdd:PRK09861 245 KEFLQSYQSPEVAKAAETIFNGGAVP 270
|
|
| TauA |
COG0715 |
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ... |
9-262 |
4.62e-07 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];
Pssm-ID: 440479 [Multi-domain] Cd Length: 297 Bit Score: 50.00 E-value: 4.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 9 LISTSIFGLAACGGK--DKDEKKLVVGAS-NVPHAE-ILEKAKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQH 84
Cdd:COG0715 1 LAALAALALAACSAAaaAAEKVTLRLGWLpNTDHAPlYVAKEKGYFKKEGLDVELVEFAGGAAALEALAAGQADFGVAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 85 IPYLekEIKDKKYDFEIAGKIHL-EPIGVYSQK---YKSLKELpDGATIIMSNSVTDHGRGLAILQKEGIlkikdgvdpv 160
Cdd:COG0715 81 PPAL--AARAKGAPVKAVAALSQsGGNALVVRKdsgIKSLADL-KGKKVAVPGGSTSHYLLRALLAKAGL---------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 161 saTPKDIadNPKNLkfktdiEPGLLPQVYNNKEGDAVLINSNYAIDAKLNPEKDAIAIEGDDSP--YANVLVVRKG--DK 236
Cdd:COG0715 148 --DPKDV--EIVNL------PPPDAVAALLAGQVDAAVVWEPFESQAEKKGGGRVLADSADLVPgyPGDVLVASEDflEE 217
|
250 260 270
....*....|....*....|....*....|....*
gi 446657732 237 DKKAIKELVEVL---------HSKEIEDFITKEYK 262
Cdd:COG0715 218 NPEAVKAFLRALlkawawaaaNPDEAAAILAKATG 252
|
|
| OsmF |
COG1732 |
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system ... |
1-60 |
2.03e-04 |
|
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441338 [Multi-domain] Cd Length: 294 Bit Score: 42.05 E-value: 2.03e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446657732 1 MKKLLLTALISTSIFGLAACGGKD--KDEKKLVVGASNVPHAEIL-EKAKPLLEKKGIELEIK 60
Cdd:COG1732 1 MKRLLLLALALAAALALAGCGLASaaAAGDTIVVGSKNFTEQEILaEIYAQALEAAGLKVERK 63
|
|
| Periplasmic_Binding_Protein_Type_2 |
cd00648 |
Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent ... |
46-233 |
3.19e-03 |
|
Type 2 periplasmic binding fold superfamily; This evolutionary model and hierarchy represent the ligand-binding domains found in solute binding proteins that serve as initial receptors in the transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1 (PBP1), but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The origin of PBP module can be traced across the distant phyla, including eukaryotes, archebacteria, and prokaryotes. The majority of PBP2 proteins are involved in the uptake of a variety of soluble substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction. The substrate binding domain of the LysR transcriptional regulators and the oligopeptide-like transport systems also contain the type 2 periplasmic binding fold and thus they are significantly homologous to that of the PBP2; however, these two families are grouped into a separate hierarchy of the PBP2 superfamily due to the large number of protein sequences.
Pssm-ID: 270214 [Multi-domain] Cd Length: 196 Bit Score: 37.94 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 46 AKPLLEKKGIELEIKKFQDYVLPNKSLADKDLDANYFQHIPYLE--KEIKDKKyDFEIAGKIHLEPIGVYSQKYKSLK-- 121
Cdd:cd00648 20 AKQLAKETGIKVELVPGSSIGTLIEALAAGDADVAVGPIAPALEaaADKLAPG-GLYIVPELYVGGYVLVVRKGSSIKgl 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657732 122 ---ELPDGATIIMSNSVTDHGRGLAILQKEGILKIKDG-VDPVSATpkdiadnpknlkfktdiepGLLPQVYNNKEGDAV 197
Cdd:cd00648 99 lavADLDGKRVGVGDPGSTAVRQARLALGAYGLKKKDPeVVPVPGT-------------------SGALAAVANGAVDAA 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 446657732 198 LINSNYAIDAKLNPEK-DAIAIEGDDSPYANVLVVRK 233
Cdd:cd00648 160 IVWVPAAERAQLGNVQlEVLPDDLGPLVTTFGVAVRK 196
|
|
| |
