|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
3-485 |
0e+00 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 1016.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 3 KLLRLFFPLSLRVRFLLATAAVVLVLSLAYGMVALIGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLHVELPENIDKQS 82
Cdd:PRK10815 1 KLLRHFFPLSLRVRFLLATAAVVLALSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLSIELPENLDLNS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 83 PTMTLIYDENGQLLWAQRDVPWLMKMIQPDWLKSNGFHEIEADVNDTSLLLSGDHTIQQQLQEVREDDDDAEMTHSVAVN 162
Cdd:PRK10815 81 PTLVLIYDENGKLLWRQRDVPWLEKMIQPEWLKKNGFHEIETDVNDSSLLLSGDHSAQQQLKEVREDDDDAEMTHSVAVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 163 VYPATSRMPKLTIVVVDTIPVELKSSYMVWSWFIYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPA 242
Cdd:PRK10815 161 VYPATSRLPKLTIVVVDTIPQELQRSYMVWSWFSYVLLANLLLVIPLLWLAAWWSLRPIEALAKQVRELEEGEREQLDPN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 243 TTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVLQSTLRSLRSEK-MSVSDAEPVMLEQISRISQQIGYY 321
Cdd:PRK10815 241 PPRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEPIMLEQISRISQQIGYY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 322 LHRASMRGG-TLLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEI 400
Cdd:PRK10815 321 LHRASMRSEhNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEI 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 401 SARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIFGRQH 480
Cdd:PRK10815 401 SARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQH 480
|
....*
gi 446658075 481 STPKD 485
Cdd:PRK10815 481 STPKD 485
|
|
| PhoQ_Sensor |
pfam08918 |
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria ... |
10-189 |
8.81e-110 |
|
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognizes divalent metal cations, and antimicrobial cationic peptides (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 430316 Cd Length: 179 Bit Score: 322.76 E-value: 8.81e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 10 PLSLRVRFLLATAAVVLVLSLAYGMVALIGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLHVELPENIDKQSPTMTLIY 89
Cdd:pfam08918 1 PFSLRTRFLLATAAVVLALSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYSLAQWDDNKLTIAVPPNLDLNSPTLVLIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 90 DENGQLLWAQRDVPWLMKMIQPDWLKSNGFHEIEADVNDTSLLLSGDHTIQQQLQEVReDDDDAEMTHSVAVNVYPATSR 169
Cdd:pfam08918 81 DENGKLLWRQRHVPELEKHIKPEWLKKNGFYELDTDTDTSSALLGNNPLAQDQLKAIN-DDDDNELTHSVAVNRYPATSR 159
|
170 180
....*....|....*....|
gi 446658075 170 MPKLTIVVVDTIPVELKSSY 189
Cdd:pfam08918 160 LPALTIVVVDTIPQELQRSD 179
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-476 |
1.22e-80 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 246.39 E-value: 1.22e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 342 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIP 421
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446658075 422 LSKREVIFDRGQRVDTLRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:cd16954 81 ESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
250-476 |
8.13e-36 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 133.11 E-value: 8.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 250 LVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAEPVMLEQIS----RISQQIGYYLHRA 325
Cdd:COG2205 2 LEEALEELEELERLK----SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIResaeRLLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 326 SMRGGTL-LSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPE-ISFVGEQNDFVEVMGNVLDNACKYCLE--FVEIS 401
Cdd:COG2205 78 RLESGKLsLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPggTITIS 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446658075 402 ARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR--PGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
194-476 |
1.13e-35 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 135.04 E-value: 1.13e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 194 WFIYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLLKSERERYDKYRTTLT 273
Cdd:COG0642 36 LLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 274 DLTHSLKTPLAVLQSTLRSLRSEKMS-VSDAEPVMLEQISRISQQIGYYLHRASMRGGTL-LSRELHPVAPLLDNLTSAL 351
Cdd:COG0642 116 NVSHELRTPLTAIRGYLELLLEELDEeQREYLETILRSADRLLRLINDLLDLSRLEAGKLeLEPEPVDLAELLEEVVELF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 352 NKVYQRKGVNISLDISPEISFV-GEQNDFVEVMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVI 428
Cdd:COG0642 196 RPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKYTPEggTVTVSVRREGDRVRISVEDTGPGIPPEDLERI 275
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446658075 429 FDRGQRVDTLRPGQGV--GLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:COG0642 276 FEPFFRTDPSRRGGGTglGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
160-476 |
1.34e-31 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 125.44 E-value: 1.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 160 AVNVYPATSRMPKLTIVVVDTIPVELKSSYMVWSWFIYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELL 239
Cdd:COG5002 53 ALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 240 NPATTRELTSLVRNLNRLLK---SERERYDKYRTTLT-DLTHSLKTPLAVLQSTLRSLRSEKMSVSDAEP----VMLEQI 311
Cdd:COG5002 133 RLSLRLSALLLGLLLLAAVErdiTELERLEQMRREFVaNVSHELRTPLTSIRGYLELLLDGAADDPEERReyleIILEEA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 312 SRISQQIG--YYLHRASmRGGTLLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEQNDFVEVMGNVLD 388
Cdd:COG5002 213 ERLSRLVNdlLDLSRLE-SGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVlGDPDRLEQVLTNLLD 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 389 NACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR----PGQGVGLAVAREITEQYEGKIVA 462
Cdd:COG5002 292 NAIKYTPEggTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRsretGGTGLGLAIVKHIVEAHGGRIWV 371
|
330
....*....|....*
gi 446658075 463 gESMLG-GARMEVIF 476
Cdd:COG5002 372 -ESEPGkGTTFTITL 385
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
374-476 |
1.41e-24 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 98.10 E-value: 1.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 374 GEQNDFVEVMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVD---TLRPGQGVGLAV 448
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
|
90 100
....*....|....*....|....*...
gi 446658075 449 AREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
382-476 |
2.85e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 96.90 E-value: 2.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 382 VMGNVLDNACKYCLEF--VEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR--PGQGVGLAVAREITEQYE 457
Cdd:cd00075 4 VLSNLLDNALKYSPPGgtIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRegGGTGLGLAIVRRIVEAHG 83
|
90
....*....|....*....
gi 446658075 458 GKIVAGESMLGGARMEVIF 476
Cdd:cd00075 84 GRITVESEPGGGTTFTVTL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
193-485 |
3.25e-22 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 98.94 E-value: 3.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 193 SWFIYVLSAnlLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTR-ELTSLVRNLNRLL----KSERERydk 267
Cdd:PRK10549 166 SWLIVALST--LLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRdELGRLAQDFNQLAstleKNEQMR--- 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 268 yRTTLTDLTHSLKTPLAVL-------QSTLRSLRSEKMSVSDAEPVMLEQISRisqqigyYLHRASM--RGGTLLSRELH 338
Cdd:PRK10549 241 -RDFMADISHELRTPLAVLrgeleaiQDGVRKFTPESVASLQAEVGTLTKLVD-------DLHQLSLsdEGALAYRKTPV 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 339 PVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEQNDFVEVMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDD 416
Cdd:PRK10549 313 DLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSggSLHISAEQRDKTLRLTFADS 392
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446658075 417 GPGIPLSKREVIFDRGQRVDTLRP----GQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIFGRQHSTPKD 485
Cdd:PRK10549 393 APGVSDEQLQKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQRE 465
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-475 |
2.61e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 88.54 E-value: 2.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 383 MGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR----PGQGVGLAVAREITEQYEG 458
Cdd:cd16949 5 LENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHGG 84
|
90
....*....|....*..
gi 446658075 459 KIVAGESMLGGARMEVI 475
Cdd:cd16949 85 KIKASNRKPGGLRVRIW 101
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
219-476 |
7.67e-20 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 91.06 E-value: 7.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 219 RPIEALAKEVRELEEHNRELLnpattreLTSLVRNLNRLLKSERERYDKYRTTLTDLT--HSLKTPLAVLQSTLRSLRSE 296
Cdd:COG3290 124 RPIDEVLAEVLETGERDEEIL-------LNGRVLVVNRVPIRDDGRVVGAVATFRDRTelERLEEELEGVKELAEALRAQ 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 297 ------KMSVsdaepvmleqISRISQQIGY-----YLHRASMRGGTLLSRELHPVA-PLLDNLTSALNKVYQRKGVNISL 364
Cdd:COG3290 197 rhdfrnHLHT----------ISGLLQLGEYdealeYIDEISEELQELIDSLLSRIGnPVLAALLLGKAARARERGIDLTI 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 365 DISPEISFVG-EQNDFVEVMGNVLDNACKYCLE------FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGqrVDT 437
Cdd:COG3290 267 DIDSDLPDLPlSDTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERG--FST 344
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 446658075 438 -LRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:COG3290 345 kLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
374-476 |
1.30e-19 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 83.96 E-value: 1.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 374 GEQNDFVEVMGNVLDNACKYCLEFVEISAR-QTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR-PGQGVGLAVARE 451
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*
gi 446658075 452 ITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTL 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
236-474 |
2.04e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 91.64 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 236 RELLNPATTREL---TSLVRN-LNRL----------LKSERERYdkyRTTL-TDLTHSLKTPLAVLqstlrslrsekmsV 300
Cdd:PRK10490 620 RQLMIPEQQRLLetfTLLIANaLERLtltaseeqarLASEREQL---RNALlAALSHDLRTPLTVL-------------F 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 301 SDAEPVML----------EQISRISQQI-------GYYLHRASMR-GGTLLSRELHPvaplLDNLT-SALNKV-YQRKGV 360
Cdd:PRK10490 684 GQAEILTLdlasegsphaRQASEIRQQVlnttrlvNNLLDMARIQsGGFNLRKEWLT----LEEVVgSALQMLePGLSGH 759
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 361 NISLDISPEISFVGEQNDFVE-VMGNVLDNACKYCLEFVE--ISARQTDEHLYIVVEDDGPGIPLSKREVIFD---RGQR 434
Cdd:PRK10490 760 PINLSLPEPLTLIHVDGPLFErVLINLLENAVKYAGAQAEigIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDkfaRGNK 839
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 446658075 435 VDTLrPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEV 474
Cdd:PRK10490 840 ESAI-PGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
203-474 |
4.72e-19 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 89.61 E-value: 4.72e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 203 LLLVI-----PLLWVAAWWSLRPIEAL---AKEV--------RELEEHNRELLnpATTRELTSLVRNLNRLLkSERERYd 266
Cdd:PRK09470 171 LLLVTmlvstPLLLWLAWSLAKPARKLknaADEVaqgnlrqhPELETGPQEFR--QAGASFNQMVTALERMM-TSQQRL- 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 267 kyrttLTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAEPVMLEqISRISQQIGYYLHRASMRGGTLLSRELHPVAPLLDN 346
Cdd:PRK09470 247 -----LSDISHELRTPLTRLQLATALLRRRQGESKELERIETE-AQRLDSMINDLLVLSRNQQKNHLERETFKANSLWSE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 347 -LTSALNKVYQRkgvNISLDIS--PEISFV-GEQNDFVEVMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPL 422
Cdd:PRK09470 321 vLEDAKFEAEQM---GKSLTVSapPGPWPInGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPE 397
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 446658075 423 SKREVIFDRGQRVDTLRP----GQGVGLAVAREITEQYEGKIVAGESMLGGARMEV 474
Cdd:PRK09470 398 EEREQIFRPFYRVDEARDresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTI 453
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
199-476 |
1.09e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 88.36 E-value: 1.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 199 LSANLLLVIPLLWVA-AWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLlkseRERYD------KYRTT 271
Cdd:PRK11100 187 AGALLLGIALLIGAGvVWWLNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELAQALESM----RVKLEgkayveQYVQT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 272 LTdltHSLKTPLAVLQSTLRSLRsEKMSVSDAEPVM---LEQISRISQQIGYYLHRASM--RGGtLLSRELHPVAPLLDN 346
Cdd:PRK11100 263 LT---HELKSPLAAIRGAAELLQ-EDPPPEDRARFTgniLTQSARLQQLIDRLLELARLeqRQE-LEVLEPVALAALLEE 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 347 LTSALNKVYQRKGVNISLDIsPEISFVGEQNDFVEVMGNVLDNAckycLEF------VEISARQTDEHLYIVVEDDGPGI 420
Cdd:PRK11100 338 LVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNA----IDFspeggtITLSAEVDGEQVALSVEDQGPGI 412
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 446658075 421 PLSKREVIFDRG---QRVDTLRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:PRK11100 413 PDYALPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
200-476 |
4.58e-18 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 86.17 E-value: 4.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 200 SANLLLVIPLLWV--AAWWSLRPIEALAKEVRE-LEEHNRELLNPATTRELTSLVR--------------NLNRLLKSER 262
Cdd:COG5000 118 AAERLLGIPLEELigKPLEELLPELDLAELLREaLERGWQEEIELTRDGRRTLLVRasplrddgyvivfdDITELLRAER 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 263 erydkyRTTLTD----LTHSLKTPLAVLQSTLRSLRS--EKMSVSDAEP------VMLEQISRISQQIGYYLHRASMRgg 330
Cdd:COG5000 198 ------LAAWGElarrIAHEIKNPLTPIQLSAERLRRklADKLEEDREDleraldTIIRQVDRLKRIVDEFLDFARLP-- 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 331 tLLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEQNDFVEVMGNVLDNACKYCLE--FVEISARQTDE 407
Cdd:COG5000 270 -EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlADRDQLEQVLINLLKNAIEAIEEggEIEVSTRREDG 348
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446658075 408 HLYIVVEDDGPGIPLSKREVIFDrgqrvdtlrP-------GQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:COG5000 349 RVRIEVSDNGPGIPEEVLERIFE---------PffttkpkGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-471 |
6.38e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 79.01 E-value: 6.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 382 VMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR----PGQGVGLAVAREITEQYE 457
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRdratGGFGLGLAIVHRVALWHG 83
|
90
....*....|....
gi 446658075 458 GKIVAGESMLGGAR 471
Cdd:cd16939 84 GHVECDDSELGGAC 97
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
190-471 |
1.97e-17 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 84.27 E-value: 1.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 190 MVWSWFIYVLSANLLLVIP-LLWVAAWW-SLRPIEALAKEVRE--LEEhnRELLNPATtreltSLVR----------NLN 255
Cdd:PRK10604 134 MRLLDIALLALIGLSLAFPvFLWMRPHWqDMLKLEAAAQRLGDghLAE--RIHFDEGS-----SLERlgvafnqmadNIN 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 256 RLLKSererydkyRTTLTD-LTHSLKTPLAVLQSTLRSLRSEkmsvSDAEPVMLEQ-ISRISQQIGYYLHRASmrggtlL 333
Cdd:PRK10604 207 ALIAS--------KKQLIDgIAHELRTPLVRLRYRLEMSDNL----SAAESQALNRdIGQLEALIEELLTYAR------L 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 334 SR---ELHPVAPLLDN-LTSALNKVYQ-RKGVNISLDISPEISFVGEQNDFVE-VMGNVLDNACKYCLEFVEISARQTDE 407
Cdd:PRK10604 269 DRpqnELHLSEPDLPAwLSTHLADIQAvTPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSLLLDGN 348
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446658075 408 HLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRP----GQGVGLAVAREITEQYEGKIVAGESMLGGAR 471
Cdd:PRK10604 349 QACLIVEDDGPGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELGGAR 416
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
121-476 |
4.06e-16 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 79.84 E-value: 4.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 121 EIEADVNDTSLLLSGDHTIQQQLQEVREDDDDAEMTHSVAVNVYPATSRMPKLTIVVVDTIPVELKSSYMVWSWFIYVLS 200
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 201 ANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELlnpatTRELTSLVRNLNRLLKSERerydkyRTTLTDLT---- 276
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITEL-----ERAEEELRELQEQLVQSEK------LAALGELAagia 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 277 HSLKTPLAVLQSTLRSLRSEKMSVSDAEPV------MLEQISRISQQIgyylhrASMRG---GTLLSRELHPVAPLLDNL 347
Cdd:COG4191 151 HEINNPLAAILGNAELLRRRLEDEPDPEELrealerILEGAERAAEIV------RSLRAfsrRDEEEREPVDLNELIDEA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 348 TSALNKVYQRKGVNISLDISPEISFV-GEQNDFVEVMGNVLDNACkYCLE-----FVEISARQTDEHLYIVVEDDGPGIP 421
Cdd:COG4191 225 LELLRPRLKARGIEVELDLPPDLPPVlGDPGQLEQVLLNLLINAI-DAMEegeggRITISTRREGDYVVISVRDNGPGIP 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446658075 422 LSKREVIFD-------RGQrvdtlrpGQGVGLAVAREITEQYEGKIVAgESMLG-GARMEVIF 476
Cdd:COG4191 304 PEVLERIFEpffttkpVGK-------GTGLGLSISYGIVEKHGGRIEV-ESEPGgGTTFTITL 358
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
121-481 |
4.51e-16 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 80.60 E-value: 4.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 121 EIEADVNDTSLLLSGDHTIQQQLQEVREDDDDAEMTHSVAVNVYPATSRMPKLTIVVVDTIPVELKSSYMVWSWFIYVLS 200
Cdd:COG4251 142 LLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 201 ANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRllkSERErydkyrttLTDLTHS-- 278
Cdd:COG4251 222 GGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELER---SNEE--------LEQFAYVas 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 279 --LKTPLAVLQSTLRSLRSEKMSVSDAEpvMLEQISRIsqqigyylHRASMRGGTL------LSR------ELHPV--AP 342
Cdd:COG4251 291 hdLREPLRKISGFSQLLEEDYGDKLDEE--GREYLERI--------RDAAERMQALiddllaYSRvgrqelEFEPVdlNE 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 343 LLDNLTSALNKVYQRKGVNISLDISPEIsfVGEQNDFVEVMGNVLDNACKYCLE----FVEISARQTDEHLYIVVEDDGP 418
Cdd:COG4251 361 LLEEVLEDLEPRIEERGAEIEVGPLPTV--RGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGI 438
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446658075 419 GIPLSKREVIFDRGQRVDTLR--PGQGVGLAVAREITEQYEGKIVAgESMLG-GARMEVIFGRQHS 481
Cdd:COG4251 439 GIDPEYAEKIFEIFQRLHSRDeyEGTGIGLAIVKKIVERHGGRIWV-ESEPGeGATFYFTLPKAPA 503
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
184-462 |
1.57e-15 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 78.58 E-value: 1.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 184 ELKSSYMVWSWFIYVLSanLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHN--RELLNPATTRELTSLVRNLNRLLKSE 261
Cdd:TIGR01386 157 HLLDALRKWLILIAVLL--VLLTALLGWWITRLGLEPLRRLSAVAARISPESldQRLDPSRAPAELRELAQSFNAMLGRL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 262 RERYDKYRTTLTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAEPVM---LEQISRISQQIGYYLHRASMRGGTL-LSREL 337
Cdd:TIGR01386 235 EDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLesnLEELERLSRMVSDMLFLARADNGQLaLERVR 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 338 HPVAPLLDNLTSALNKVYQRKGVniSLDISPEISFVGEQNDFVEVMGNVLDNACKYCLE--FVEISARQTDEHLYIVVED 415
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERGV--RIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDggTITVRIERRSDEVRVSVSN 392
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 446658075 416 DGPGIPLSKREVIFDRGQRVDTLR----PGQGVGLAVAREITEQYEGKIVA 462
Cdd:TIGR01386 393 PGPGIPPEHLSRLFDRFYRVDPARsnsgEGTGLGLAIVRSIMEAHGGRASA 443
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
204-476 |
2.23e-15 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 78.03 E-value: 2.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 204 LLVIPLLWVA-AWWSLR----PIEALAKEVRELEEHN-RELLNPATTRELTSLVRNLNRLLKSERERYDKyRTTLT-DLT 276
Cdd:PRK09467 159 TLAIGLLSVAgGWLFIRiqnrPLVALEHAALQVGKGEiPPPLREYGASEVRSVTRAFNQMAAGIKQLEDD-RTLLMaGVS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 277 HSLKTPLavlqsTLRSLRSEKMS----------VSDAEpvmlEQISRISQQIGYylhrasMRGGTLLSRELHPVAPLLDN 346
Cdd:PRK09467 238 HDLRTPL-----TRIRLATEMMSeedgylaesiNKDIE----ECNAIIEQFIDY------LRTGQEMPMEMADLNALLGE 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 347 LTSALNKvYQRKgvnISLDISPEISFVGEQNDFVE-VMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPLSKR 425
Cdd:PRK09467 303 VIAAESG-YERE---IETALQPGPIEVPMNPIAIKrALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQL 378
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 446658075 426 EVIFDRGQRVDTLR--PGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:PRK09467 379 KHLFQPFTRGDSARgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
379-476 |
8.82e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 70.18 E-value: 8.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 379 FVEVMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRP----GQGVGLAVAREI 452
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....
gi 446658075 453 TEQYEGKIVAGESMLGGARMEVIF 476
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
105-459 |
1.25e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 75.82 E-value: 1.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 105 LMKMIQPDWLKSNGFHEIEADVNDTSLLLSGDHTIQQQLQEVREDDDDAEMTHSVAVNVYPATSRMPKLTIVVVDTIPVE 184
Cdd:COG2972 69 LLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSEL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 185 LKSSYMVWSWFIYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLLkserER 264
Cdd:COG2972 149 FRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMV----ER 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 265 YDKYRTTLTDLTHSLK-TPLAVLQS---------TLRSLRSekMSVSDAEpvmlEQISRISQQIGYYLhRASMRGG---T 331
Cdd:COG2972 225 IKELIEEVYELELEKKeAELKALQAqinphflfnTLNSIRW--LAELEDP----EEAEEMLEALSKLL-RYSLSKGdelV 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 332 LLSRELHPVAPLLdnltsALNKVYQRKGVNISLDISPEIsfvGEQNDFVEVMGNVLDNACKYCLE------FVEISARQT 405
Cdd:COG2972 298 TLEEELELIKSYL-----EIQKLRFGDRLEVEIEIDEEL---LDLLIPKLILQPLVENAIEHGIEpkegggTIRISIRKE 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446658075 406 DEHLYIVVEDDGPGIPLSKREVIFdrgQRVDTLRPGQGVGLAVAREITEQYEGK 459
Cdd:COG2972 370 GDRLVITVEDNGVGMPEEKLEKLL---EELSSKGEGRGIGLRNVRERLKLYYGE 420
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
215-460 |
6.07e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 73.06 E-value: 6.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 215 WWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLlKSERErydkyrtTLTD-----------LTHSLKTPL 283
Cdd:PRK09303 95 WWPRWQQEGATYSGLGENLQPSEIDSGRYSQELLQLSDELFVL-RQENE-------TLLEqlkfkdrvlamLAHDLRTPL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 284 AVLQSTLRSLRSEKMSVSDAEPVM------------LEQISRISQQIgyyLHRASMRGGTLlsrELHPV----APLLDNL 347
Cdd:PRK09303 167 TAASLALETLELGQIDEDTELKPAlieqlqdqarrqLEEIERLITDL---LEVGRTRWEAL---RFNPQkldlGSLCQEV 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 348 TSALNKVYQRKGVNISLDISPEISFV-GEQNDFVEVMGNVLDNACKYCLEFVEISA---RQTDEHLYIVVEDDGPGIPLS 423
Cdd:PRK09303 241 ILELEKRWLAKSLEIQTDIPSDLPSVyADQERIRQVLLNLLDNAIKYTPEGGTITLsmlHRTTQKVQVSICDTGPGIPEE 320
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 446658075 424 KREVIFD---RGQRvDTLRPGQGVGLAVAREITEQYEGKI 460
Cdd:PRK09303 321 EQERIFEdrvRLPR-DEGTEGYGIGLSVCRRIVRVHYGQI 359
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
379-474 |
1.95e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 66.16 E-value: 1.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 379 FVEVMGNVLDNACKYCLEF------VEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGqrVDTLRPG-QGVGLAVARE 451
Cdd:cd16915 1 LITIVGNLIDNALDALAATgapnkqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERG--VSTKGQGeRGIGLALVRQ 78
|
90 100
....*....|....*....|...
gi 446658075 452 ITEQYEGKIVAGESMLGGARMEV 474
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSI 101
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-474 |
1.92e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 63.58 E-value: 1.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 381 EVMGNVLDNACKYCLEFVEISAR-QTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVD-TLRPGQGVGLAVAREITEQYEG 458
Cdd:cd16940 16 LLLRNLVDNAVRYSPQGSRVEIKlSADDGAVIRVEDNGPGIDEEELEALFERFYRSDgQNYGGSGLGLSIVKRIVELHGG 95
|
90
....*....|....*.
gi 446658075 459 KIVAGESMLGGARMEV 474
Cdd:cd16940 96 QIFLGNAQGGGLEAWV 111
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
219-483 |
1.40e-11 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 66.85 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 219 RPIEALAKEVRELEEHNREL--LNPATTRELTSLVRNlNRLLKSERERYDKYRTT-LTDLTHSLKTPLAVLQSTLRSL-- 293
Cdd:PRK11466 393 RLMDAFRSNVHALNRHREQLaaQVKARTAELQELVIE-HRQARAEAEKASQAKSAfLAAMSHEIRTPLYGILGTAQLLad 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 294 -------RSEKMSVSDAEPVMLEQISRISQqigyylHRASMRGGTLLSRELHPVAP--LLDNLTSALNKVYQRKGVNISL 364
Cdd:PRK11466 472 npalnaqRDDLRAITDSGESLLTILNDILD------YSAIEAGGKNVSVSDEPFEPrpLLESTLQLMSGRVKGRPIRLAT 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 365 DISPEI--SFVGEQNDFVEVMGNVLDNACKYCLE-FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPG 441
Cdd:PRK11466 546 DIADDLptALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGG 625
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446658075 442 QGVGLAVAREITEQYEGKIVAGESMLGGARMEVIFGRQHSTP 483
Cdd:PRK11466 626 TGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVATA 667
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-473 |
1.58e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 60.93 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 382 VMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR--PGQGVGLAVAREITEQYEGK 459
Cdd:cd16950 4 VLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARgtSGTGLGLAIVQRISDAHGGS 83
|
90
....*....|....*.
gi 446658075 460 IVAGESMLGG--ARME 473
Cdd:cd16950 84 LTLANRAGGGlcARIE 99
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
150-460 |
1.68e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 66.33 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 150 DDDAEMTHS----VAVNVYPATSRMPKLTIVVVDTIPV------ELKSSYMVWSWFIYvlsanlLLVIPLLWVAAWWSLR 219
Cdd:PRK09835 138 HGHGHMEHSnwrmIALPVGPLVDGKPIYTLLIALSIDFhlhyinDLKNKLIMTASVIS------LLIVFIVLLAVHKGHA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 220 PIEALAKEVRELEEHNREL-LNPATTR-ELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVLQSTLRSLRSEK 297
Cdd:PRK09835 212 PIRSVSRQIQNITSKDLDVrLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQS 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 298 MSVSDAEPVM---LEQISRISQQIGYYLHRASMRggtllSRELHPVAPLLDnLTSALNKVY-------QRKGVNISLDIS 367
Cdd:PRK09835 292 RSQKELEDVLysnLEELTRMAKMVSDMLFLAQAD-----NNQLIPEKKMLD-LADEVGKVFdffeawaEERGVELRFVGD 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 368 PeISFVGEQNDFVEVMGNVLDNACKYCL--EFVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR----PG 441
Cdd:PRK09835 366 P-CQVAGDPLMLRRAISNLLSNALRYTPagEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRqrkgEG 444
|
330
....*....|....*....
gi 446658075 442 QGVGLAVAREITEQYEGKI 460
Cdd:PRK09835 445 SGIGLAIVKSIVVAHKGTV 463
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
380-462 |
1.18e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 58.74 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 380 VEVMGNVLDNACKYCLEF---VEISARQTDEHLYIVVEDDGPGIPLSKREVIFDR--GQRVDTLRPGQ--GVGLAVAREI 452
Cdd:cd16953 2 GQVLRNLIGNAISFSPPDtgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRfyTERPANEAFGQhsGLGLSISRQI 81
|
90
....*....|
gi 446658075 453 TEQYEGKIVA 462
Cdd:cd16953 82 IEAHGGISVA 91
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
380-469 |
3.43e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 56.95 E-value: 3.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 380 VEVMGNVLDNACKYCLEF----VEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR--PGQGVGLAVAREIT 453
Cdd:cd16921 2 GQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREeyEGTGVGLAIVRKII 81
|
90
....*....|....*.
gi 446658075 454 EQYEGKIvAGESMLGG 469
Cdd:cd16921 82 ERHGGRI-WLESEPGE 96
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
203-459 |
5.90e-10 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 60.75 E-value: 5.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 203 LLLVIPLLWVAAW---WSLRPIEALAKEvreLEEHNRELLNP----ATTRELTSLVRNLNRLLKSERERYDKYRTTLTDL 275
Cdd:PRK10755 68 LVMVSLTLLICFQavrWITRPLAELQKE---LEARTADNLTPiaihSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 276 THSLKTPLAVLQSTLRSLrsEKMSVSDAEPvMLEQISRISQQIGYYLHRAsmRGGTLLSRELHPVAPLLDN----LTSAL 351
Cdd:PRK10755 145 AHELRTPLAGIRLHLELL--EKQHHIDVAP-LIARLDQMMHTVEQLLQLA--RAGQSFSSGHYQTVKLLEDvilpSQDEL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 352 NKVYQRKGVNISLDISPEISFVgeQNDFV---EVMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKRE 426
Cdd:PRK10755 220 SEMLEQRQQTLLLPESAADITV--QGDATllrLLLRNLVENAHRYSPEgsTITIKLSQEDGGAVLAVEDEGPGIDESKCG 297
|
250 260 270
....*....|....*....|....*....|...
gi 446658075 427 VIFDRGQRVDTLRPGQGVGLAVAREITEQYEGK 459
Cdd:PRK10755 298 ELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQ 330
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-475 |
1.08e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 55.51 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 381 EVMGNVLDNACKYCLEFVEISAR--QTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQGVGLAVAREITEQYEG 458
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRtwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKHGG 85
|
90
....*....|....*...
gi 446658075 459 KIVAgESMLG-GARMEVI 475
Cdd:cd16943 86 TIRV-ASVPGgGTRFTII 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
382-468 |
1.66e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 55.19 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 382 VMGNVLDNACKYCLE---FVEISARQTDE---HLYIVVEDDGPGIPLSKREVIFDRGQRVD--TLRP--GQGVGLAVARE 451
Cdd:cd16922 4 ILLNLLGNAIKFTEEgevTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADssTTRKygGTGLGLAISKK 83
|
90
....*....|....*..
gi 446658075 452 ITEQYEGKIVAgESMLG 468
Cdd:cd16922 84 LVELMGGDISV-ESEPG 99
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-460 |
1.73e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 55.60 E-value: 1.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 382 VMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRP----GQGVGLAVAREITEQ 455
Cdd:cd16947 24 ILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGLGLTITKRLAES 103
|
....*
gi 446658075 456 YEGKI 460
Cdd:cd16947 104 MGGSI 108
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-462 |
2.08e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 54.70 E-value: 2.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 382 VMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLR--PGQGVGLAVAREITEQYE 457
Cdd:cd16923 4 VFSNLLSNAIKYSPEntRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRntEGAGLGLSIAKAIIELHG 83
|
....*
gi 446658075 458 GKIVA 462
Cdd:cd16923 84 GSASA 88
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
361-460 |
2.13e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.54 E-value: 2.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 361 NISLDIS-----PEISFVGEQNDFVEVMGNVLDNAckycLEFV--------EISARQTDEHLYIVVEDDGPGIPLSKREV 427
Cdd:PRK11086 411 GITLIISedsqlPDSGDEDQVHELITILGNLIENA----LEAVggeeggeiSVSLHYRNGWLHCEVSDDGPGIAPDEIDA 486
|
90 100 110
....*....|....*....|....*....|...
gi 446658075 428 IFDRGqrVDTLRPGQGVGLAVAREITEQYEGKI 460
Cdd:PRK11086 487 IFDKG--YSTKGSNRGVGLYLVKQSVENLGGSI 517
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-460 |
7.56e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 53.23 E-value: 7.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 383 MGNVLDNACKYCLEF--VEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRG---QRVDTLRPGQGVGLAVAREITEQYE 457
Cdd:cd16945 9 INNLLDNAIDFSPEGglIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFyslPRPHSGQKSTGLGLAFVQEVAQLHG 88
|
...
gi 446658075 458 GKI 460
Cdd:cd16945 89 GRI 91
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
411-474 |
7.91e-09 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 53.27 E-value: 7.91e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446658075 411 IVVEDDGPGIPLSKREVIFDRGQRVDTL----RPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEV 474
Cdd:cd16925 40 LTVSDSGPGIPPNLREEIFERFRQGDGSstraHGGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQV 107
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-460 |
1.76e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 52.96 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 360 VNISLDISPEISFvgEQNDFVEVMGNVLDNACKYCLE------FVEISARQTDEHLYIVVEDDGPGiplskrEVIFDRGQ 433
Cdd:cd16935 20 FTIEIDIPILLPI--SPLDLCIIFGNLLDNAIEACAKidkenrFIHLKIRQKKGFLIISIENSYEG------ELKKKNGL 91
|
90 100
....*....|....*....|....*...
gi 446658075 434 RVDTLR-PGQGVGLAVAREITEQYEGKI 460
Cdd:cd16935 92 FLSTKKdKNHGIGLKSIREIVKKYNGNL 119
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
354-481 |
5.49e-08 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 55.36 E-value: 5.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 354 VYQRKGVNISLDISPEISFV---GEQndFVEVMGNVLDNACKYCLEFVEISAR---QTDEHLYIVVEDDGPGIPLSKREV 427
Cdd:PRK11360 475 AGVQARVDFETELDNELPPIwadPEL--LKQVLLNILINAVQAISARGKIRIRtwqYSDGQVAVSIEDNGCGIDPELLKK 552
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446658075 428 IFDrgqRVDTLRP-GQGVGLAVAREITEQYEGKIVAgESMLG-GARMEVIFGRQHS 481
Cdd:PRK11360 553 IFD---PFFTTKAkGTGLGLALSQRIINAHGGDIEV-ESEPGvGTTFTLYLPINPQ 604
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
277-460 |
1.08e-07 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 54.35 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 277 HSLKTPLAVLQSTLRSLRSEKMSVSDAEPVMLEQISRISQQIGYYLHRAS----MRGGTLLSRELHPVAPLLdnLTSALN 352
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKpqavNKEKENINELIQDVVTLL--ETEAIL 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 353 KvyqrkGVNISLDISPEISFV-GEQNDFVEVMGNVLDNAckycLE------FVEISARQTDEHLYIVVEDDGPGIPlskR 425
Cdd:COG5805 374 H-----NIQIRLELLDEDPFIyCDENQIKQVFINLIKNA----IEampnggTITIHTEEEDNSVIIRVIDEGIGIP---E 441
|
170 180 190
....*....|....*....|....*....|....*.
gi 446658075 426 EVIFDRGQRVDTLR-PGQGVGLAVAREITEQYEGKI 460
Cdd:COG5805 442 ERLKKLGEPFFTTKeKGTGLGLMVSYKIIENHNGTI 477
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
241-448 |
1.96e-07 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 53.09 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 241 PATTRELTSLVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVLQSTLRSLRSEKMSVS---DAEPVMLEQISRISQQ 317
Cdd:PRK11006 181 PYTEGQLLMVARDVTQMHQLEGAR----RNFFANVSHELRTPLTVLQGYLEMMQDQPLEGAlreKALHTMREQTQRMEGL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 318 IGYYLHrasmrggtlLSR-ELHPVAPLLDNL-TSALNKVYQRKGV-------NISLDISPEISFVGEQNDFVEVMGNVLD 388
Cdd:PRK11006 257 VKQLLT---------LSKiEAAPTIDLNEKVdVPMMLRVLEREAQtlsqgkhTITFEVDNSLKVFGNEDQLRSAISNLVY 327
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446658075 389 NACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRP----GQGVGLAV 448
Cdd:PRK11006 328 NAVNHTPEgtHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqtgGSGLGLAI 393
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-475 |
2.73e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 48.61 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 381 EVMGNVLDNACKYCLEF----VEISARQTDEHLYIVVEDDGPGIPLSKREVIFDrgqRVDTLRP---GQGVGLAVAREIT 453
Cdd:cd16976 3 QVLMNLLQNALDAMGKVenprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFD---PFFTTKPvgkGTGLGLSISYGIV 79
|
90 100
....*....|....*....|..
gi 446658075 454 EQYEGKIVAGESMLGGARMEVI 475
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFD 101
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
203-452 |
3.27e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 52.73 E-value: 3.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 203 LLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNpaTTR---ELTSLVRNLNRLLKS-----ERERydkyRTTlTD 274
Cdd:PRK10337 171 LPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLN--ATGvpsEVRPLVEALNQLFARthammVRER----RFT-SD 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 275 LTHSLKTPLAVLQstlrsLRSEKMSVSDAEPVMLEqisRISQQIGYYLHRASMRGGTL--LSR--------ELHPVaPLL 344
Cdd:PRK10337 244 AAHELRSPLAALK-----VQTEVAQLSDDDPQARK---KALLQLHAGIDRATRLVDQLltLSRldsldnlqDVAEI-PLE 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 345 DNLTSALNKVY---QRKGVNISLDI-SPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDEHLyiVVEDDGPGI 420
Cdd:PRK10337 315 DLLQSAVMDIYhtaQQAGIDVRLTLnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNF--TVRDNGPGV 392
|
250 260 270
....*....|....*....|....*....|....*..
gi 446658075 421 PLSKREVIFDR-----GQRVdtlrPGQGVGLAVAREI 452
Cdd:PRK10337 393 TPEALARIGERfyrppGQEA----TGSGLGLSIVRRI 425
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
221-470 |
3.93e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.77 E-value: 3.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 221 IEALAKEVR----ELEEHNRELLNPATTREltslvRNLNRLLKSERERYDKYR-----TTLTDLTHSLKTPLAVLQSTLR 291
Cdd:COG4192 382 IGRIARLLRvfrdQAIEKTQELETEIEERK-----RIEKNLRQTQDELIQAAKmavvgQTMTSLAHELNQPLNAMSMYLF 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 292 SLRSEKMSVSDAEpvMLEQISRISQQIGYY------LHRASMRGGTllsrELHPVaPLLDNLTSALNKVYQR-KGVNISL 364
Cdd:COG4192 457 SAKKALEQENYAQ--LPTSLDKIEGLIERMdkiiksLRQFSRKSDT----PLQPV-DLRQVIEQAWELVESRaKPQQITL 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 365 DISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQ--TDEHLYIVVEDDGPGIPLSKREVI-FDRGQRVdtlrpG 441
Cdd:COG4192 530 HIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLlsNAENLRVAISDNGNGWPLVDKLFTpFTTTKEV-----G 604
|
250 260
....*....|....*....|....*....
gi 446658075 442 QGVGLAVAREITEQYEGKIVAGESMLGGA 470
Cdd:COG4192 605 LGLGLSICRSIMQQFGGDLYLASTLERGA 633
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
346-460 |
4.42e-07 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 51.77 E-value: 4.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 346 NLTSALNKVYQ------RKGVNISLDISPEISFV-GEQNDFVEVMGNVLDNACK------------YCLEFVEISARQTD 406
Cdd:COG3852 205 NLHEVLERVLEllraeaPKNIRIVRDYDPSLPEVlGDPDQLIQVLLNLVRNAAEampeggtitirtRVERQVTLGGLRPR 284
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446658075 407 EHLYIVVEDDGPGIPLSKREVIFD-----RGQrvdtlrpGQGVGLAVAREITEQYEGKI 460
Cdd:COG3852 285 LYVRIEVIDNGPGIPEEILDRIFEpffttKEK-------GTGLGLAIVQKIVEQHGGTI 336
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
246-450 |
8.00e-07 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 51.95 E-value: 8.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 246 ELTSLVRNLNRLLKSERERYD------KYRTT-------------------LTDLTHSLKTPL-------AVLQSTlrSL 293
Cdd:PRK15347 351 ELGSIAKAYNQLLDTLNEQYDtlenkvAERTQalaeakqraeqankrksehLTTISHEIRTPLngvlgalELLQNT--PL 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 294 RSEKMSVSDA----EPVMLEQI------SRI-SQQIgyylhrasmrggtLLSRELHPVAPLLDNLTSALNKVYQRKGVNI 362
Cdd:PRK15347 429 TAEQMDLADTarqcTLSLLAIInnlldfSRIeSGQM-------------TLSLEETALLPLLDQAMLTIQGPAQSKSLTL 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 363 SLDISPEI--SFVGEQNDFVEVMGNVLDNACKYClEFVEISAR--QTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTL 438
Cdd:PRK15347 496 RTFVGAHVplYLHLDSLRLRQILVNLLGNAVKFT-ETGGIRLRvkRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH 574
|
250
....*....|..
gi 446658075 439 RPGQGVGLAVAR 450
Cdd:PRK15347 575 SQGTGLGLTIAS 586
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
401-470 |
1.64e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 46.62 E-value: 1.64e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 401 SARQTDEHLYIVVEDDGPGIPLSKREVIFDrgQRVDTLRPGQGVGLAVAREITEQYEGKIVAGESMLGGA 470
Cdd:cd16920 30 TSPADDRAVTISVKDTGPGIAEEVAGQLFD--PFYTTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
385-476 |
2.50e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 46.30 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 385 NVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIP---LSKREVIFDRGQRVDTLRPGQGVGLAVAREITEQYEGK 459
Cdd:cd16975 11 NIISNACQYAPEggTVSISIYDEEEYLYFEIWDNGHGFSeqdLKKALELFYRDDTSRRSGGHYGMGLYIAKNLVEKHGGS 90
|
90
....*....|....*..
gi 446658075 460 IVAGESMLGGArmEVIF 476
Cdd:cd16975 91 LIIENSQKGGA--EVTV 105
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
385-476 |
7.37e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 44.89 E-value: 7.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 385 NVLDNACKYCLEFVEISAR-QTDEH-LYIVVEDDGPGIPLSKREVIFDRGQRVDTLRP----GQGVGLAVAREITEQYEG 458
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRwSQEESgARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 446658075 459 KIVAgESMLG-GARMEVIF 476
Cdd:cd16952 87 RLLI-ASELGkGSRFTCLF 104
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
375-458 |
1.14e-05 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 44.13 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 375 EQNDFVEVMGNVLDNA---CKYCLE--FVEISARQTDEHLYIVVE-------DDGPGIPLSKRevifDRGqrvdtlrpGQ 442
Cdd:pfam14501 2 SDVDLCVIFGNLLDNAieaCSKIDDnrFIRLKIREKQNFLIIRIEntyegelKFEGKLPSTKT----KGD--------GH 69
|
90
....*....|....*.
gi 446658075 443 GVGLAVAREITEQYEG 458
Cdd:pfam14501 70 GIGLKSIRRIVKKYGG 85
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
245-468 |
1.68e-05 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 47.28 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 245 RELTSLVRNLNRLLKSERerYDKYRTTLTDLTHSLKTPLAVLQSTLRSLRSEKMSvsDAEP---VMLEQISRISQQIGYY 321
Cdd:COG5809 249 RDITERKKLEELLRKSEK--LSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDE--EQKTyldIMLSELDRIESIISEF 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 322 LhrasmrggtLLSR------ELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEQNDFVEVMGNVLDNAckyc 394
Cdd:COG5809 325 L---------VLAKpqaikyEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDIlGDENQLKQVFINLLKNA---- 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 395 LEF------VEISARQTDEHLYIV-VEDDGPGIPLSKREVIFDrgqrvdtlrP-------GQGVGLAVAREITEQYEGKI 460
Cdd:COG5809 392 IEAmpeggnITIETKAEDDDKVVIsVTDEGCGIPEERLKKLGE---------PfyttkekGTGLGLMVSYKIIEEHGGKI 462
|
....*...
gi 446658075 461 VAgESMLG 468
Cdd:COG5809 463 TV-ESEVG 469
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-476 |
2.04e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 43.68 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 381 EVMGNVLDNACKYCLEF--------VEISARQtDEHLYIVVEDDGPGIPLSKREVIFDrgQRVDTLRPGQGVGLAVAREI 452
Cdd:cd16944 7 QVLTNILKNAAEAIEGRpsdvgevrIRVEADQ-DGRIVLIVCDNGKGFPREMRHRATE--PYVTTRPKGTGLGLAIVKKI 83
|
90 100
....*....|....*....|....
gi 446658075 453 TEQYEGKIVAGESMLGGARMEVIF 476
Cdd:cd16944 84 MEEHGGRISLSNREAGGACIRIIL 107
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
409-460 |
3.03e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 43.16 E-value: 3.03e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446658075 409 LYIVVEDDGPGIPLSKREVIFDrgQRVDTLRPGQGVGLAVAREITEQYEGKI 460
Cdd:cd16918 44 LRVSVIDNGPGIPPDLQDTIFY--PMVSGRENGTGLGLAIAQNIVSQHGGVI 93
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
375-446 |
2.27e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 43.67 E-value: 2.27e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446658075 375 EQNDFVEVMGNVLDNACKYCLE------FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQ-GVGL 446
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASLRsdegnkIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEhGIGL 507
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
272-330 |
2.48e-04 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 39.12 E-value: 2.48e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446658075 272 LTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAE--PVMLEQISRISQQIGYYLHRASMRGG 330
Cdd:pfam00512 6 LANLSHELRTPLTAIRGYLELLRDEKLDEEQREylETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
381-457 |
2.59e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.67 E-value: 2.59e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446658075 381 EVMGNVLDNACKYCLE-FVEISARQTDEHLYIVVEDDGPGIPLSkrevifDRGQRVDTLRPGqGVGLAVAREITEQYE 457
Cdd:COG2172 41 EAVTNAVRHAYGGDPDgPVEVELELDPDGLEIEVRDEGPGFDPE------DLPDPYSTLAEG-GRGLFLIRRLMDEVE 111
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
203-476 |
3.50e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 42.30 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 203 LLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLlksERERYDkyrttltDLTHSLktp 282
Cdd:COG4585 3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAREEERRRI---ARELHD-------GVGQSL--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 283 lAVLQSTLRSLRSEKMSVSDAEPVMLEQISRISQQIGyylhrASMRGgtlLSRELHPVAPLLDNLTSAL----NKVYQRK 358
Cdd:COG4585 70 -SAIKLQLEAARRLLDADPEAAREELEEIRELAREAL-----AELRR---LVRGLRPPALDDLGLAAALeelaERLLRAA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 359 GVNISLDISPEISFVGEqndfvEVMGNV-------LDNACKYCL-EFVEISARQTDEHLYIVVEDDGPGIPLSKrevifd 430
Cdd:COG4585 141 GIRVELDVDGDPDRLPP-----EVELALyrivqeaLTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEA------ 209
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446658075 431 rgqrvdtlRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIF 476
Cdd:COG4585 210 --------APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
272-330 |
4.06e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 38.70 E-value: 4.06e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446658075 272 LTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAE--PVMLEQISRISQQIGYYLHRASMRGG 330
Cdd:smart00388 6 LANLSHELRTPLTAIRGYLELLLDTELSEEQREylETILREAERLLRLINDLLDLSRIEAG 66
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
275-460 |
4.93e-04 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 42.38 E-value: 4.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 275 LTHSLKTPLAVLQSTLRSLrsEKM----SVSDAEPVMLEQISRIsqqigyylhRAsmrggtLLSRELHPVAP---LLDNL 347
Cdd:PRK11073 137 LAHEIKNPLGGLRGAAQLL--SKAlpdpALTEYTKVIIEQADRL---------RN------LVDRLLGPQRPgthVTESI 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 348 TSALNKVYQ----RKGVNISL----DIS-PEISFVGEQNDfvEVMGNVLDNAckycLEFV-----EISAR-----QTDEH 408
Cdd:PRK11073 200 HKVAERVVQlvslELPDNVRLirdyDPSlPELAHDPDQIE--QVLLNIVRNA----LQALgpeggTITLRtrtafQLTLH 273
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446658075 409 -------LYIVVEDDGPGIPLSKREVIFdrGQRVDTLRPGQGVGLAVAREITEQYEGKI 460
Cdd:PRK11073 274 geryrlaARIDIEDNGPGIPPHLQDTLF--YPMVSGREGGTGLGLSIARNLIDQHSGKI 330
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
398-446 |
8.81e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 38.58 E-value: 8.81e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 446658075 398 VEISARQTDEHLYIVVEDDGPGIPlskREVIFDRGQRVDtlrPGQGVGL 446
Cdd:cd16924 27 VTISALKEDNHVMIEVEDNGRGID---PKVLNILGKKPK---EGNGIGL 69
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
196-476 |
1.24e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.43 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 196 IYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLLKSERERydkyRTTLTDL 275
Cdd:COG3920 227 LAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEK----ELLLREL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 276 THSLKTPLAVLQSTLRsLRSEKMSVSDAEPVMLEQISRI---SQqigyyLHRasmrggtLLSRELH----PVAPLLDNLT 348
Cdd:COG3920 303 HHRVKNNLQVVSSLLR-LQARRADDPEAREALEESQNRIqalAL-----VHE-------LLYQSEDwegvDLRDYLRELL 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 349 SALNKVYQRKGVNISLDIsPEISFVGEQ--------NDFVevmgnvlDNACKYCLE-----FVEISARQTDEHLYIVVED 415
Cdd:COG3920 370 EPLRDSYGGRGIRIELDG-PDVELPADAavplglilNELV-------TNALKHAFLsgeggRIRVSWRREDGRLRLTVSD 441
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446658075 416 DGPGIPLSkreviFDRGQRvdtlrpgQGVGLAVAREITEQYEGKIVAGESmlGGARMEVIF 476
Cdd:COG3920 442 NGVGLPED-----VDPPAR-------KGLGLRLIRALVRQLGGTLELDRP--EGTRVRITF 488
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
356-460 |
1.25e-03 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 41.31 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 356 QRKGVNISLDISPEISFVgeQNDfVEVMGNVLDNACKYCLE------FVEISARQTDEHLYIVVEDDGPGIPLSKREVIF 429
Cdd:PRK10364 325 NSREIQLRFTANDTLPEI--QAD-PDRLTQVLLNLYLNAIQaigqhgVISVTASESGAGVKISVTDSGKGIAADQLEAIF 401
|
90 100 110
....*....|....*....|....*....|.
gi 446658075 430 DrgQRVDTLRPGQGVGLAVAREITEQYEGKI 460
Cdd:PRK10364 402 T--PYFTTKAEGTGLGLAVVHNIVEQHGGTI 430
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
333-483 |
2.29e-03 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 40.43 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 333 LSRELHPVAPLLdnltsalnKVYQRKGVNISLDISPEISFV-GEQNDFVEVMGNVLDNACKYCLE--FVEISARQTD--- 406
Cdd:PRK13837 522 LSELVTEIAPLL--------RVSLPPGVELDFDQDQEPAVVeGNPAELQQVLMNLCSNAAQAMDGagRVDISLSRAKlra 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 407 ------------EHLYIVVEDDGPGIPLSKREVIFDRgqrVDTLRP-GQGVGLAVAREITEQYEGKIvAGESMLG-GARM 472
Cdd:PRK13837 594 pkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEP---FFTTRAgGTGLGLATVHGIVSAHAGYI-DVQSTVGrGTRF 669
|
170
....*....|.
gi 446658075 473 EVIFGRQHSTP 483
Cdd:PRK13837 670 DVYLPPSSKVP 680
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-455 |
2.91e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 37.27 E-value: 2.91e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446658075 382 VMGNVLDNACKYCLE--FVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQ---GVGLAVAREITEQ 455
Cdd:cd16948 9 IIGQIVSNALKYSKQggKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQestGMGLYLVKKLCDK 87
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
381-461 |
8.87e-03 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 38.77 E-value: 8.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446658075 381 EVMGNVLDNACKYCLE-FVEIS-ARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQ-----GVGLAVAREIT 453
Cdd:PRK11091 401 QILWNLISNAVKFTQQgGVTVRvRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKpatgtGIGLAVSKRLA 480
|
....*...
gi 446658075 454 EQYEGKIV 461
Cdd:PRK11091 481 QAMGGDIT 488
|
|
| |
