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Conserved domains on  [gi|446660645|ref|WP_000737991|]
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MULTISPECIES: AlpA family transcriptional regulator [Enterobacteriaceae]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10007181)

helix-turn-helix DNA-binding protein similar to Mycobacterium phage excisionase, which is necessary for the excision of prophage from the host genome by site-specific recombination at the attachment site

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  15808743|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
19-70 1.29e-14

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


:

Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 61.48  E-value: 1.29e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 446660645 19 DRMIREKECRELTTLANSTRWKLEKEGKFPKRIKIGSTAVAYRLSEVQAWIR 70
Cdd:COG3311   6 DRLLRLKEVAELLGVSRSTIYRLIKKGEFPKPVKLGGRSVRWRESEVEAWLA 57
 
Name Accession Description Interval E-value
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
19-70 1.29e-14

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 61.48  E-value: 1.29e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 446660645 19 DRMIREKECRELTTLANSTRWKLEKEGKFPKRIKIGSTAVAYRLSEVQAWIR 70
Cdd:COG3311   6 DRLLRLKEVAELLGVSRSTIYRLIKKGEFPKPVKLGGRSVRWRESEVEAWLA 57
Phage_AlpA pfam05930
Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and ...
 19-69 4.44e-11

Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light. Several of the sequences in this family are thought to be DNA-binding proteins.


Pssm-ID: 399137  Cd Length: 51  Bit Score: 52.33  E-value: 4.44e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446660645  19 DRMIREKECRELTTLANSTRWKLEKEGKFPKRIKIGSTAVAYRLSEVQAWI 69
Cdd:pfam05930  1 MRILRLREVEQKTGLSRSSIYRLMKEGEFPKPVRLGVRAVAWVESEIDQWI 51
 
Name Accession Description Interval E-value
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
19-70 1.29e-14

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 61.48  E-value: 1.29e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 446660645 19 DRMIREKECRELTTLANSTRWKLEKEGKFPKRIKIGSTAVAYRLSEVQAWIR 70
Cdd:COG3311   6 DRLLRLKEVAELLGVSRSTIYRLIKKGEFPKPVKLGGRSVRWRESEVEAWLA 57
Phage_AlpA pfam05930
Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and ...
 19-69 4.44e-11

Prophage CP4-57 regulatory protein (AlpA); This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light. Several of the sequences in this family are thought to be DNA-binding proteins.


Pssm-ID: 399137  Cd Length: 51  Bit Score: 52.33  E-value: 4.44e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446660645  19 DRMIREKECRELTTLANSTRWKLEKEGKFPKRIKIGSTAVAYRLSEVQAWI 69
Cdd:pfam05930  1 MRILRLREVEQKTGLSRSSIYRLMKEGEFPKPVRLGVRAVAWVESEIDQWI 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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