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MULTISPECIES: penicillin-binding protein 2 [Bacillus]
Protein Classification
peptidoglycan D,D-transpeptidase FtsI family protein ( domain architecture ID 11433609 )
peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-693
9.93e-148
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 441.96
E-value: 9.93e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 1 MK K qe KK SG R VVPL RL NI LFL C V F LLF SGIIIQ L GKV Q IFD G ET Y KNEL E KRENA TV GLSV PRG K I F DR E GN PVVD N KSL 80
Cdd:COG0768 1 MK R -- KK EK R LFRR RL LL LFL L V L LLF LLLVGR L FYL Q VVE G DE Y AELA E ENRIR TV PIPA PRG L I Y DR N GN VLAT N VPV 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 81 RTITYTKVKGVKQ EE I lks A RQ LA DIIEMPQ E DID K L tetdkkdfwmqlnpelaqdlvskkeidkfrdkditgkeldkki 160
Cdd:COG0768 79 YSLYADPEEVKDP EE T --- A EK LA KLLGLDP E ELR K K ------------------------------------------- 112
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 161 ed LK R K R vtdknlqeltakdievlaikskmts G F qma P QII K KDV S EQ E Y A V I se NLAN LPGV DASVDWE R I Y VNDG L FR 240
Cdd:COG0768 113 -- LK K K S ------------------------- R F --- P VYL K RNL S PE E A A R I -- RALK LPGV YVEAEYK R Y Y PYGE L AA 160
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 241 S VLG N V SNA deglprerldyylvrdy SRN D RV GKS YI E QQ YED V L H GT KKEV R SIA D KQ G NT IR T - ETVSEGKS GK N L T L 319
Cdd:COG0768 161 H VLG Y V GEI ----------------- NGG D GI GKS GL E KA YED L L R GT PGKR R VEV D AR G RV IR D l GEEKPPVP GK D L V L 223
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 320 TID ME LQK KV EE SIE K ILKQ YK G sesml DRAF VV M M N PK N G QV L S MA GK ------ RL V EKDG kmev E DYALGTLTSS YE L 393
Cdd:COG0768 224 TID SD LQK IA EE ALK K AVEE YK A ----- KSGA VV V M D PK T G EI L A MA SY psfdpn LF V GGPD ---- E PLRNRAVQGT YE P 294
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 394 GST V K GA T VLTGF E TNA ITP G T H F YD - APMKFK G TK e KKS W K -- NF G DIDDLR AL QV SSNV YMFNI AL KI a G V D yvknss 470
Cdd:COG0768 295 GST F K PF T AAAAL E EGV ITP D T T F DC p GYYRVG G RT - IRD W D rg GH G TLTLTE AL AK SSNV GFYKL AL RL - G I D ------ 366
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 471 ldikqeyfd K MRY Y FRQ FGLG VQ TGIDLP N E TA G QIGKKDN - Q PG FLLDY SIGQ YDTY TPLQLAQ YIST IANGG YRM KP Q 549
Cdd:COG0768 367 --------- K LYD Y LKK FGLG QK TGIDLP G E AS G LLPSPKR w Y PG ETATM SIGQ GLSV TPLQLAQ AYAA IANGG VLV KP H 437
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 550 I V Q EI REQT vqknev G K VV QS i EP V VL N R I d MKQ E YINQ V K EG FRK V FQ E GD GT GV RA f QKAP Y KP AGKTGTAQ T V YG G E 629
Cdd:COG0768 438 L V K EI VDPD ------ G E VV KE - EP E VL R R V - ISP E TAET V R EG MEG V VN E PG GT AR RA - AIPG Y RV AGKTGTAQ V V DI G N 508
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446666422 630 NAIGRNA kgdrrec YNLTLA G Y AP Y D D P EV A FS VVV PWVENDKS G -- INSDIGK E VLD AY FD L KNK 693
Cdd:COG0768 509 GGYYKGR ------- HIASFV G F AP A D N P RY A VA VVV ENPGGGAY G gt VAAPVFR E IME AY LR L LGP 567
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-693
9.93e-148
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 441.96
E-value: 9.93e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 1 MK K qe KK SG R VVPL RL NI LFL C V F LLF SGIIIQ L GKV Q IFD G ET Y KNEL E KRENA TV GLSV PRG K I F DR E GN PVVD N KSL 80
Cdd:COG0768 1 MK R -- KK EK R LFRR RL LL LFL L V L LLF LLLVGR L FYL Q VVE G DE Y AELA E ENRIR TV PIPA PRG L I Y DR N GN VLAT N VPV 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 81 RTITYTKVKGVKQ EE I lks A RQ LA DIIEMPQ E DID K L tetdkkdfwmqlnpelaqdlvskkeidkfrdkditgkeldkki 160
Cdd:COG0768 79 YSLYADPEEVKDP EE T --- A EK LA KLLGLDP E ELR K K ------------------------------------------- 112
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 161 ed LK R K R vtdknlqeltakdievlaikskmts G F qma P QII K KDV S EQ E Y A V I se NLAN LPGV DASVDWE R I Y VNDG L FR 240
Cdd:COG0768 113 -- LK K K S ------------------------- R F --- P VYL K RNL S PE E A A R I -- RALK LPGV YVEAEYK R Y Y PYGE L AA 160
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 241 S VLG N V SNA deglprerldyylvrdy SRN D RV GKS YI E QQ YED V L H GT KKEV R SIA D KQ G NT IR T - ETVSEGKS GK N L T L 319
Cdd:COG0768 161 H VLG Y V GEI ----------------- NGG D GI GKS GL E KA YED L L R GT PGKR R VEV D AR G RV IR D l GEEKPPVP GK D L V L 223
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 320 TID ME LQK KV EE SIE K ILKQ YK G sesml DRAF VV M M N PK N G QV L S MA GK ------ RL V EKDG kmev E DYALGTLTSS YE L 393
Cdd:COG0768 224 TID SD LQK IA EE ALK K AVEE YK A ----- KSGA VV V M D PK T G EI L A MA SY psfdpn LF V GGPD ---- E PLRNRAVQGT YE P 294
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 394 GST V K GA T VLTGF E TNA ITP G T H F YD - APMKFK G TK e KKS W K -- NF G DIDDLR AL QV SSNV YMFNI AL KI a G V D yvknss 470
Cdd:COG0768 295 GST F K PF T AAAAL E EGV ITP D T T F DC p GYYRVG G RT - IRD W D rg GH G TLTLTE AL AK SSNV GFYKL AL RL - G I D ------ 366
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 471 ldikqeyfd K MRY Y FRQ FGLG VQ TGIDLP N E TA G QIGKKDN - Q PG FLLDY SIGQ YDTY TPLQLAQ YIST IANGG YRM KP Q 549
Cdd:COG0768 367 --------- K LYD Y LKK FGLG QK TGIDLP G E AS G LLPSPKR w Y PG ETATM SIGQ GLSV TPLQLAQ AYAA IANGG VLV KP H 437
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 550 I V Q EI REQT vqknev G K VV QS i EP V VL N R I d MKQ E YINQ V K EG FRK V FQ E GD GT GV RA f QKAP Y KP AGKTGTAQ T V YG G E 629
Cdd:COG0768 438 L V K EI VDPD ------ G E VV KE - EP E VL R R V - ISP E TAET V R EG MEG V VN E PG GT AR RA - AIPG Y RV AGKTGTAQ V V DI G N 508
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446666422 630 NAIGRNA kgdrrec YNLTLA G Y AP Y D D P EV A FS VVV PWVENDKS G -- INSDIGK E VLD AY FD L KNK 693
Cdd:COG0768 509 GGYYKGR ------- HIASFV G F AP A D N P RY A VA VVV ENPGGGAY G gt VAAPVFR E IME AY LR L LGP 567
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
15-689
1.34e-114
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 357.22
E-value: 1.34e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 15 R LNI L FLC V FL LF SGIIIQ L GKV Q IFD GE T Y KNEL E KRENAT V GLSV PRG K I F DR E G NPVV DN KS lrti TYT kvkgvkqe 94
Cdd:TIGR03423 2 R ALV L GGL V LA LF GVLAAR L FYL Q VIR GE E Y ATLS E DNRIRL V PIPP PRG L I L DR N G VLLA DN RP ---- SFS -------- 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 95 eilksarqladi I E MPQ E DI D K L TE T dkkdfwmq L n PE LA QD L vskkeidkfrdk D ITGKELDKKIED LKR K R vtdknlq 174
Cdd:TIGR03423 70 ------------ L E IVP E KV D D L DA T -------- L - DR LA KL L ------------ D LDPEDIARFLKE LKR S R ------- 109
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 175 eltakdievlaikskmts G F Q ma P QII K K D VS E Q E Y A VISE N LAN LPGV DASVDWE R I Y VNDG L FRS VLG N V S -- N ADE g 252
Cdd:TIGR03423 110 ------------------ R F E -- P IPL K S D LT E E E V A RFAV N QYR LPGV EIEARLK R Y Y PYGE L AAH VLG Y V G ei N EED - 168
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 253 lp R ERL DY ylv RD Y SRN D RV GKS Y IE QQ YED V L H G TKKEVRSIADKQ G NT IRT ETVSEGKS GK N L T LTID ME LQ KK vees 332
Cdd:TIGR03423 169 -- L ERL EP --- AN Y AGG D YI GKS G IE KY YED E L R G KPGYREVEVNAR G RV IRT LSRVPPVP GK D L V LTID AR LQ QA ---- 239
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 333 I EK I L KQYK G S esmldraf VV M M N P KN G QV L S M A ---------- GKRLVE KD G K M -- EVE D YA L -- GTLTSS Y EL GST V K 398
Cdd:TIGR03423 240 A EK A L GGRR G A -------- VV V M D P RT G EI L A M V stpsfdpnlf VDGISS KD Y K A ll NDP D RP L ln RAIQGV Y PP GST F K 311
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 399 GATV L TGF E TNA ITP G T HF Y D a P MK F K - G TKEKKS WK -- NF G DI D DLR A LQV S SN VY MFNI AL KI a G V D yvknssldikq 475
Cdd:TIGR03423 312 PVVA L AAL E EGV ITP E T RI Y C - P GY F Q l G GRRFRC WK rg GH G RV D LRK A IEE S CD VY FYQL AL RL - G I D ----------- 378
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 476 eyfd K MRY Y FRQ FG L G VQ TGIDLP N E TA G QIG --------- KKDNQ PG FL L DY SIGQ - Y DTY TPLQLA QYISTI ANGG YR 545
Cdd:TIGR03423 379 ---- K IAE Y AKR FG F G QK TGIDLP G E KS G LVP srewkrkrf GQPWY PG DT L NV SIGQ g Y VLV TPLQLA VATAAL ANGG KL 454
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 546 M KP QI V QE I REQT vqknev G K VV QSI EP V VL NRIDMKQ E YINQ V K EG F R K V FQEGD GT GV RA FQKA PYK P AGKTGTAQ T V 625
Cdd:TIGR03423 455 Y KP HL V KS I EDPD ------ G G VV RRT EP E VL RPLPISP E NLDV V R EG M R D V VNGPG GT AR RA RLGL PYK M AGKTGTAQ V V 528
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446666422 626 YGGENAIGRNAKGDR R ECYNLTLAGY APYD D P EV A FS V V vpw VE NDKS G -- INSD I GKEVL DAY FD 689
Cdd:TIGR03423 529 SLKQGEKYDAEQIPE R LRDHALFVAF APYD N P KI A VA V I --- VE HGGG G ss AAAP I ARKIM DAY LL 591
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
350-685
4.58e-71
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 233.46
E-value: 4.58e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 350 AFV V MMN PK N G Q VL S M A GK R lv EK D GKMEVEDYALGTL TS S YE L GST V K GA T V L TGFETNAIT P GTHFY D A P M K FK G T K E 429
Cdd:pfam00905 1 GSA V VLD PK T G E VL A M V GK P -- SY D PNGFIGPLRNRAV TS R YE P GST F K PF T A L AALDNGVLK P DETIF D W P G K QQ G G K S 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 430 KKS W KNFGD - I DD LR - AL QV SSN V YM FNI A L K IA gvdyvknssldikqey F DK M R Y Y FRQ FG L G VQ TGI D LP N E T AG QIG 507
Cdd:pfam00905 79 IGD W NQDQV g I GT LR q AL EY SSN W YM QKL A Q K LG ---------------- A DK L R S Y LKK FG Y G NK TGI G LP G E N AG YLT 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 508 KKDNQ p G FLLDYS IG qy D T Y TPLQ L AQ YIST IANGG YRMK P QI V QE I reqtvqknevgkv VQSIE P V VLN RIDMKQEYIN 587
Cdd:pfam00905 143 PYWLE - G ATASFG IG -- L T I TPLQ Q AQ AYAA IANGG KLVP P HL V KS I ------------- EDKVD P K VLN KLPISKSTAE 206
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 588 Q VK EGF R K V fq EG DGTG VRAFQKAP YK P AGKTGTAQ TVYGGEN aigrnak G DRRECYNLTLA GYAP Y D D P EV AF S V VVPW 667
Cdd:pfam00905 207 K VK DML R L V -- VN DGTG TGTAAVPG YK V AGKTGTAQ VAGPKGG ------- G YYDGAQIGWFV GYAP A D N P KY AF A V LIDD 277
330
....*....|....*....
gi 446666422 668 VENDKS G INSD - I G K EV L D 685
Cdd:pfam00905 278 PKRYYG G KVAA p I F K DI L E 296
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
15-708
6.91e-41
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 158.78
E-value: 6.91e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 15 R LNIL FL CVF LL FSGI I IQ L GKV QI FDGET Y KNELEKRENAT V GLSVP RG K I F DR E G N P VVD N ksl RTI T ytkvkgvkqe 94
Cdd:PRK10795 21 R ALVA FL GIL LL TGVL I AN L YNL QI VRFTD Y QTRSNENRIKL V PIAPS RG I I Y DR N G T P LAL N --- RTI Y ---------- 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 95 eilksar QL adii EM PQ E DI D K L TE T dkkdfwmqlnpelaqdlvskkeidkfrdkditgkeldkk IED L K rkrvtdk NLQ 174
Cdd:PRK10795 88 ------- QL ---- EM MP E KV D N L QQ T --------------------------------------- LDA L R ------- SVV 110
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 175 E LT AK DI EVLAIKSKMTSG F QMA P qi I K KDVS E QEY A VISE N LANL PGV DASVDWE R I Y VNDGLFRS V L G N VS NA - D EGL 253
Cdd:PRK10795 111 D LT DD DI AAFRKERARSRR F TSI P -- V K TNLT E VQV A RFAV N QYRF PGV EVKGYQR R Y Y PYGSALTH V I G Y VS KI n D KDV 188
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 254 pr ERLD YY - LVRD Y SRNDRV GK SY IE QQ YEDVLHG TK -- K EV R si ADKQ G NT IR TETVSEGKS G KNLT LT I D ME LQ K kve 330
Cdd:PRK10795 189 -- ERLD KE g KLAN Y AATHDI GK LG IE RY YEDVLHG KT gy E EV E -- VNNR G RV IR QLHEQPPQA G HDIY LT L D LK LQ Q --- 261
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 331 e S IE KI L K qyk GS esmld RA F VV MMN P KN G QV L SMAGKR ---------- LVE KD -- G KMEVEDYA L GTLTSS -- Y ELG ST 396
Cdd:PRK10795 262 - Y IE TL L A --- GS ----- RA A VV VTD P RT G GI L ALVSTP sydpnlfvdg ISS KD ys G LLNDPNRP L INRATQ gv Y PPA ST 332
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 397 VK GATVLTGFETNA IT PG T HFY D A ----- P MKF K GTKEK K S W KN f G DIDDLRA L QV S SNVYMFNI A LKIA gvdyvknssl 471
Cdd:PRK10795 333 VK PYVAVSALSAGV IT RN T SLF D P gwwql P GSE K RYRDW K K W GH - G RLNVTKS L EE S ADTFFYQV A YDMG ---------- 401
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 472 dikqey F D KMRYYFRQ FG L G VQ TGIDL PN E TA G QIG --------- KK DNQP G FLLDYS IGQ - Y D T Y TP L Q LAQYIS T IA N 541
Cdd:PRK10795 402 ------ I D RLSEWMGK FG Y G HY TGIDL AE E RS G NMP trewkqkrf KK PWYQ G DTIPVG IGQ g Y W T A TP I Q MSKALM T LI N 475
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 542 G G YRMK P QIVQEIR E Q tvqknev GK V V QSIE P VVLNRI D MKQE Y INQV K E G FRK V FQEGD GT GVRA F QK APYK P A G K T GT 621
Cdd:PRK10795 476 D G IVKV P HLLMSTA E D ------- GK Q V PWVQ P HEPPVG D IHSG Y WEIA K D G MYG V ANRPN GT AHKY F AS APYK I A A K S GT 548
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 622 AQ t V Y G GENAIGR NA K -- GD R RECYN L TL A g Y APY DD P E VA FSVV vpw V EN DKS G IN - SD I GKEV LD a YFD L -- K N KR L T 696
Cdd:PRK10795 549 AQ - V F G LKANETY NA H ki AE R LRDHK L MT A - F APY NN P Q VA VAII --- L EN GGA G PA v GT I MRQI LD - HIM L gd N N TD L P 622
730
....*....|..
gi 446666422 697 G E A P KTD A SKEN 708
Cdd:PRK10795 623 A E N P AVA A AEDH 634
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-693
9.93e-148
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 441.96
E-value: 9.93e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 1 MK K qe KK SG R VVPL RL NI LFL C V F LLF SGIIIQ L GKV Q IFD G ET Y KNEL E KRENA TV GLSV PRG K I F DR E GN PVVD N KSL 80
Cdd:COG0768 1 MK R -- KK EK R LFRR RL LL LFL L V L LLF LLLVGR L FYL Q VVE G DE Y AELA E ENRIR TV PIPA PRG L I Y DR N GN VLAT N VPV 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 81 RTITYTKVKGVKQ EE I lks A RQ LA DIIEMPQ E DID K L tetdkkdfwmqlnpelaqdlvskkeidkfrdkditgkeldkki 160
Cdd:COG0768 79 YSLYADPEEVKDP EE T --- A EK LA KLLGLDP E ELR K K ------------------------------------------- 112
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 161 ed LK R K R vtdknlqeltakdievlaikskmts G F qma P QII K KDV S EQ E Y A V I se NLAN LPGV DASVDWE R I Y VNDG L FR 240
Cdd:COG0768 113 -- LK K K S ------------------------- R F --- P VYL K RNL S PE E A A R I -- RALK LPGV YVEAEYK R Y Y PYGE L AA 160
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 241 S VLG N V SNA deglprerldyylvrdy SRN D RV GKS YI E QQ YED V L H GT KKEV R SIA D KQ G NT IR T - ETVSEGKS GK N L T L 319
Cdd:COG0768 161 H VLG Y V GEI ----------------- NGG D GI GKS GL E KA YED L L R GT PGKR R VEV D AR G RV IR D l GEEKPPVP GK D L V L 223
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 320 TID ME LQK KV EE SIE K ILKQ YK G sesml DRAF VV M M N PK N G QV L S MA GK ------ RL V EKDG kmev E DYALGTLTSS YE L 393
Cdd:COG0768 224 TID SD LQK IA EE ALK K AVEE YK A ----- KSGA VV V M D PK T G EI L A MA SY psfdpn LF V GGPD ---- E PLRNRAVQGT YE P 294
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 394 GST V K GA T VLTGF E TNA ITP G T H F YD - APMKFK G TK e KKS W K -- NF G DIDDLR AL QV SSNV YMFNI AL KI a G V D yvknss 470
Cdd:COG0768 295 GST F K PF T AAAAL E EGV ITP D T T F DC p GYYRVG G RT - IRD W D rg GH G TLTLTE AL AK SSNV GFYKL AL RL - G I D ------ 366
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 471 ldikqeyfd K MRY Y FRQ FGLG VQ TGIDLP N E TA G QIGKKDN - Q PG FLLDY SIGQ YDTY TPLQLAQ YIST IANGG YRM KP Q 549
Cdd:COG0768 367 --------- K LYD Y LKK FGLG QK TGIDLP G E AS G LLPSPKR w Y PG ETATM SIGQ GLSV TPLQLAQ AYAA IANGG VLV KP H 437
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 550 I V Q EI REQT vqknev G K VV QS i EP V VL N R I d MKQ E YINQ V K EG FRK V FQ E GD GT GV RA f QKAP Y KP AGKTGTAQ T V YG G E 629
Cdd:COG0768 438 L V K EI VDPD ------ G E VV KE - EP E VL R R V - ISP E TAET V R EG MEG V VN E PG GT AR RA - AIPG Y RV AGKTGTAQ V V DI G N 508
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446666422 630 NAIGRNA kgdrrec YNLTLA G Y AP Y D D P EV A FS VVV PWVENDKS G -- INSDIGK E VLD AY FD L KNK 693
Cdd:COG0768 509 GGYYKGR ------- HIASFV G F AP A D N P RY A VA VVV ENPGGGAY G gt VAAPVFR E IME AY LR L LGP 567
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
15-689
1.34e-114
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 357.22
E-value: 1.34e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 15 R LNI L FLC V FL LF SGIIIQ L GKV Q IFD GE T Y KNEL E KRENAT V GLSV PRG K I F DR E G NPVV DN KS lrti TYT kvkgvkqe 94
Cdd:TIGR03423 2 R ALV L GGL V LA LF GVLAAR L FYL Q VIR GE E Y ATLS E DNRIRL V PIPP PRG L I L DR N G VLLA DN RP ---- SFS -------- 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 95 eilksarqladi I E MPQ E DI D K L TE T dkkdfwmq L n PE LA QD L vskkeidkfrdk D ITGKELDKKIED LKR K R vtdknlq 174
Cdd:TIGR03423 70 ------------ L E IVP E KV D D L DA T -------- L - DR LA KL L ------------ D LDPEDIARFLKE LKR S R ------- 109
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 175 eltakdievlaikskmts G F Q ma P QII K K D VS E Q E Y A VISE N LAN LPGV DASVDWE R I Y VNDG L FRS VLG N V S -- N ADE g 252
Cdd:TIGR03423 110 ------------------ R F E -- P IPL K S D LT E E E V A RFAV N QYR LPGV EIEARLK R Y Y PYGE L AAH VLG Y V G ei N EED - 168
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 253 lp R ERL DY ylv RD Y SRN D RV GKS Y IE QQ YED V L H G TKKEVRSIADKQ G NT IRT ETVSEGKS GK N L T LTID ME LQ KK vees 332
Cdd:TIGR03423 169 -- L ERL EP --- AN Y AGG D YI GKS G IE KY YED E L R G KPGYREVEVNAR G RV IRT LSRVPPVP GK D L V LTID AR LQ QA ---- 239
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 333 I EK I L KQYK G S esmldraf VV M M N P KN G QV L S M A ---------- GKRLVE KD G K M -- EVE D YA L -- GTLTSS Y EL GST V K 398
Cdd:TIGR03423 240 A EK A L GGRR G A -------- VV V M D P RT G EI L A M V stpsfdpnlf VDGISS KD Y K A ll NDP D RP L ln RAIQGV Y PP GST F K 311
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 399 GATV L TGF E TNA ITP G T HF Y D a P MK F K - G TKEKKS WK -- NF G DI D DLR A LQV S SN VY MFNI AL KI a G V D yvknssldikq 475
Cdd:TIGR03423 312 PVVA L AAL E EGV ITP E T RI Y C - P GY F Q l G GRRFRC WK rg GH G RV D LRK A IEE S CD VY FYQL AL RL - G I D ----------- 378
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 476 eyfd K MRY Y FRQ FG L G VQ TGIDLP N E TA G QIG --------- KKDNQ PG FL L DY SIGQ - Y DTY TPLQLA QYISTI ANGG YR 545
Cdd:TIGR03423 379 ---- K IAE Y AKR FG F G QK TGIDLP G E KS G LVP srewkrkrf GQPWY PG DT L NV SIGQ g Y VLV TPLQLA VATAAL ANGG KL 454
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 546 M KP QI V QE I REQT vqknev G K VV QSI EP V VL NRIDMKQ E YINQ V K EG F R K V FQEGD GT GV RA FQKA PYK P AGKTGTAQ T V 625
Cdd:TIGR03423 455 Y KP HL V KS I EDPD ------ G G VV RRT EP E VL RPLPISP E NLDV V R EG M R D V VNGPG GT AR RA RLGL PYK M AGKTGTAQ V V 528
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446666422 626 YGGENAIGRNAKGDR R ECYNLTLAGY APYD D P EV A FS V V vpw VE NDKS G -- INSD I GKEVL DAY FD 689
Cdd:TIGR03423 529 SLKQGEKYDAEQIPE R LRDHALFVAF APYD N P KI A VA V I --- VE HGGG G ss AAAP I ARKIM DAY LL 591
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
350-685
4.58e-71
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 233.46
E-value: 4.58e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 350 AFV V MMN PK N G Q VL S M A GK R lv EK D GKMEVEDYALGTL TS S YE L GST V K GA T V L TGFETNAIT P GTHFY D A P M K FK G T K E 429
Cdd:pfam00905 1 GSA V VLD PK T G E VL A M V GK P -- SY D PNGFIGPLRNRAV TS R YE P GST F K PF T A L AALDNGVLK P DETIF D W P G K QQ G G K S 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 430 KKS W KNFGD - I DD LR - AL QV SSN V YM FNI A L K IA gvdyvknssldikqey F DK M R Y Y FRQ FG L G VQ TGI D LP N E T AG QIG 507
Cdd:pfam00905 79 IGD W NQDQV g I GT LR q AL EY SSN W YM QKL A Q K LG ---------------- A DK L R S Y LKK FG Y G NK TGI G LP G E N AG YLT 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 508 KKDNQ p G FLLDYS IG qy D T Y TPLQ L AQ YIST IANGG YRMK P QI V QE I reqtvqknevgkv VQSIE P V VLN RIDMKQEYIN 587
Cdd:pfam00905 143 PYWLE - G ATASFG IG -- L T I TPLQ Q AQ AYAA IANGG KLVP P HL V KS I ------------- EDKVD P K VLN KLPISKSTAE 206
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 588 Q VK EGF R K V fq EG DGTG VRAFQKAP YK P AGKTGTAQ TVYGGEN aigrnak G DRRECYNLTLA GYAP Y D D P EV AF S V VVPW 667
Cdd:pfam00905 207 K VK DML R L V -- VN DGTG TGTAAVPG YK V AGKTGTAQ VAGPKGG ------- G YYDGAQIGWFV GYAP A D N P KY AF A V LIDD 277
330
....*....|....*....
gi 446666422 668 VENDKS G INSD - I G K EV L D 685
Cdd:pfam00905 278 PKRYYG G KVAA p I F K DI L E 296
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
15-708
6.91e-41
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 158.78
E-value: 6.91e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 15 R LNIL FL CVF LL FSGI I IQ L GKV QI FDGET Y KNELEKRENAT V GLSVP RG K I F DR E G N P VVD N ksl RTI T ytkvkgvkqe 94
Cdd:PRK10795 21 R ALVA FL GIL LL TGVL I AN L YNL QI VRFTD Y QTRSNENRIKL V PIAPS RG I I Y DR N G T P LAL N --- RTI Y ---------- 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 95 eilksar QL adii EM PQ E DI D K L TE T dkkdfwmqlnpelaqdlvskkeidkfrdkditgkeldkk IED L K rkrvtdk NLQ 174
Cdd:PRK10795 88 ------- QL ---- EM MP E KV D N L QQ T --------------------------------------- LDA L R ------- SVV 110
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 175 E LT AK DI EVLAIKSKMTSG F QMA P qi I K KDVS E QEY A VISE N LANL PGV DASVDWE R I Y VNDGLFRS V L G N VS NA - D EGL 253
Cdd:PRK10795 111 D LT DD DI AAFRKERARSRR F TSI P -- V K TNLT E VQV A RFAV N QYRF PGV EVKGYQR R Y Y PYGSALTH V I G Y VS KI n D KDV 188
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 254 pr ERLD YY - LVRD Y SRNDRV GK SY IE QQ YEDVLHG TK -- K EV R si ADKQ G NT IR TETVSEGKS G KNLT LT I D ME LQ K kve 330
Cdd:PRK10795 189 -- ERLD KE g KLAN Y AATHDI GK LG IE RY YEDVLHG KT gy E EV E -- VNNR G RV IR QLHEQPPQA G HDIY LT L D LK LQ Q --- 261
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 331 e S IE KI L K qyk GS esmld RA F VV MMN P KN G QV L SMAGKR ---------- LVE KD -- G KMEVEDYA L GTLTSS -- Y ELG ST 396
Cdd:PRK10795 262 - Y IE TL L A --- GS ----- RA A VV VTD P RT G GI L ALVSTP sydpnlfvdg ISS KD ys G LLNDPNRP L INRATQ gv Y PPA ST 332
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 397 VK GATVLTGFETNA IT PG T HFY D A ----- P MKF K GTKEK K S W KN f G DIDDLRA L QV S SNVYMFNI A LKIA gvdyvknssl 471
Cdd:PRK10795 333 VK PYVAVSALSAGV IT RN T SLF D P gwwql P GSE K RYRDW K K W GH - G RLNVTKS L EE S ADTFFYQV A YDMG ---------- 401
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 472 dikqey F D KMRYYFRQ FG L G VQ TGIDL PN E TA G QIG --------- KK DNQP G FLLDYS IGQ - Y D T Y TP L Q LAQYIS T IA N 541
Cdd:PRK10795 402 ------ I D RLSEWMGK FG Y G HY TGIDL AE E RS G NMP trewkqkrf KK PWYQ G DTIPVG IGQ g Y W T A TP I Q MSKALM T LI N 475
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 542 G G YRMK P QIVQEIR E Q tvqknev GK V V QSIE P VVLNRI D MKQE Y INQV K E G FRK V FQEGD GT GVRA F QK APYK P A G K T GT 621
Cdd:PRK10795 476 D G IVKV P HLLMSTA E D ------- GK Q V PWVQ P HEPPVG D IHSG Y WEIA K D G MYG V ANRPN GT AHKY F AS APYK I A A K S GT 548
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 622 AQ t V Y G GENAIGR NA K -- GD R RECYN L TL A g Y APY DD P E VA FSVV vpw V EN DKS G IN - SD I GKEV LD a YFD L -- K N KR L T 696
Cdd:PRK10795 549 AQ - V F G LKANETY NA H ki AE R LRDHK L MT A - F APY NN P Q VA VAII --- L EN GGA G PA v GT I MRQI LD - HIM L gd N N TD L P 622
730
....*....|..
gi 446666422 697 G E A P KTD A SKEN 708
Cdd:PRK10795 623 A E N P AVA A AEDH 634
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
59-305
1.24e-32
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 123.97
E-value: 1.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 59 LSV PRG K I F DR E G NPVVD NK SLRTI T Y T K v KGV K QEEI LK S A RQ LA DII empqedidkltetdkkdfwmqlnpelaqdlv 138
Cdd:pfam03717 2 IPA PRG E I Y DR N G VVLAT NK PVYSL T I T P - SKL K KADA LK T A LK LA KLL ------------------------------- 49
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 139 skkeidkfrdkditgkeld KKI EDL KRKRV T DKN L Q eltakdievlaiksk M T S GFQMA P QI IKK DV SE Q E Y A V I S ENL A 218
Cdd:pfam03717 50 ------------------- SNY EDL DDEDL T ERF L K --------------- M N S YKSYY P VV IKK NL SE E E V A R I E ENL L 95
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 219 N LPGV DASV D WE R I Y VNDG L FRSV LG N V SNAD E glpr E R L DY YL VRD YSR N D R VGKS YI E Q QYE D VL H G TKKEVRSIA D K 298
Cdd:pfam03717 96 E LPGV SIET D PV R Y Y PYGE L AAHL LG Y V GEIT E ---- E E L EK YL DKG YSR G D L VGKS GL E K QYE S VL R G KDGVRQVEV D A 171
....*..
gi 446666422 299 Q G NT IR T 305
Cdd:pfam03717 172 L G RV IR E 178
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
289-623
4.56e-28
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 120.03
E-value: 4.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 289 KK E VRSIADKQ ----- G NT I R T etvsegksgknltl T I D ME LQK KV E ESIEKI L KQY K GSES mld R A FV V MMN PK N G Q VL 363
Cdd:COG0744 278 RR E LEELLGED dlyrg G LK I Y T -------------- T L D PK LQK AA E KAVKNV L PEG K PGGL --- Q A AL V VVD PK T G E VL 340
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 364 S M A G K R lvek D GKMEVEDY A LGTL tss YEL GST V K GATVLTGF E TN a I TP G T HFY D A P MK F K G tkek KS W -- KN F ----- 436
Cdd:COG0744 341 A M V G G R ---- D YGKSQFNR A TQAK --- RQP GST F K PFVYAAAL E QG - Y TP A T TVD D E P VT F P G ---- GG W sp KN Y dgryr 408
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 437 G DIDDLR AL QV S S N VYMFNI A LKI a G V D Y V K nssldikq EYFDKM ryyfrqfglgvqt GI D lpnetagqi GKK D NQ P GFL 516
Cdd:COG0744 409 G PVTLRE AL AN S L N TPAVRL A QEV - G L D K V V -------- DTARRL ------------- GI T --------- SPL D PN P SLA 457
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 517 L dysi G QYDT y T PL QL A QYIS T I ANGG YRMK P QIVQEIREQT vqknev GKV VQSIE P VVLNR I D mk Q E YINQVKEGFRK V 596
Cdd:COG0744 458 L ---- G TSEV - S PL EM A SAYA T F ANGG VYVE P HAITKVTDAD ------ GKV LYEAK P KCEQV I S -- P E VAYLMTDMLQD V 524
330 340
....*....|....*....|....*..
gi 446666422 597 FQE G D G TGV R a FQKA P Y kp AGKTGT AQ 623
Cdd:COG0744 525 VTS G T G RAA R - LPGR P V -- AGKTGT TN 548
PBP_1a_fam
TIGR02074 penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
263-674
6.10e-14
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain]
Cd Length: 531
Bit Score: 74.99
E-value: 6.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 263 VRDYSRNDRVG K SYIEQQYEDVLHGTKK E VRSIAD ---- KQ G NT I R T etvsegksgknltl T I D MEL QK KV E ESIEKI L K 338
Cdd:TIGR02074 180 INEPIQLYLQT K KSEQYKAPYFVDYVIQ E LEEEYG eely TG G LK I Y T -------------- T L D LDA QK AA E KVLNTG L R 245
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 339 QYKGSESMLDR A FV V MMN P KN G Q V LSMA G K R LVE K DGK meve DY A LGTLTSS yel GST V K GATVLTGF E T n AI TP G T HFY 418
Cdd:TIGR02074 246 VAGRRDGDDLQ A AL V AID P DT G A V RALV G G R DYG K SQF ---- NR A TQAKRQP --- GST F K PFVYAAAL E K - GL TP A T IVN 317
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 419 D A P MKFK G TK ekk S W -- KN F ----- G DIDDLR AL QV S S N VYMFNIALKI a G V D Y V K nssldikqeyfdkmr YYFRQ FG lg 491
Cdd:TIGR02074 318 D E P ITYN G NG --- P W sp KN Y gggyr G NVTLRQ AL AQ S R N IPAVRLLQEV - G L D K V V --------------- ALAKR FG -- 376
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 492 vqtg I DL P netagqig KKDNQP gflld YSI G QYDT y T PL QL A QYISTI ANGG YRMK P QIVQE I REQT vqknev GKV VQSI 571
Cdd:TIGR02074 377 ---- I TS P -------- LDPVLS ----- LAL G TVEV - S PL EM A SAYAVF ANGG KYVE P HGIRK I VDRD ------ GKV IYEN 432
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 572 E P VVLNR I DMKQE YI - NQV keg FRK V FQE G D G TGV R AFQ kap YKP AGKTGT A Q tvyggenaigr N AK gdrrecy NLTLA G 650
Cdd:TIGR02074 433 K P KTTQV I SPATA YI m TDM --- LKG V VES G T G RSA R LPG --- RPV AGKTGT T Q ----------- N WR ------- DAWFV G 488
410 420
....*....|....*....|....
gi 446666422 651 Y A PY ddpeva FSVV V p WV EN D KSG 674
Cdd:TIGR02074 489 Y T PY ------ YVTA V - WV GY D DKK 505
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
277-665
9.11e-12
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 68.31
E-value: 9.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 277 I E QQYEDV L H G TKK E VRSIA D KQ G NT I RTETVSEGKSGK NL T L T ID ME LQ KK V EESIEKILKQY K g S ES mldr AFV V MMN 356
Cdd:PRK15105 191 V E KSFDKW L T G QPG E RIVRK D RY G RV I EDISSTDSQAAH NL A L S ID ER LQ AL V YRELNNAVAFN K - A ES ---- GSA V LVD 265
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 357 PKN G Q VL S MA GKRLVEKDGKMEVEDY A LG -- TL T SSY E L GSTVK GAT V L T GFETNAITPGTHFYDA P MKFK G t K E K K SWK 434
Cdd:PRK15105 266 VNT G E VL A MA NSPSYNPNNLSGTPKD A MR nr AI T DVF E P GSTVK PMV V M T ALQRGVVKENSVLNTV P YRIN G - H E I K DVA 344
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 435 NFGDIDDLRA LQ V SSNV YMFNI AL KIAGVDY V KNS S ldikqeyfdkmryyfr Q FGLG VQ T GID L PN E TA G QIGK K DNQPG 514
Cdd:PRK15105 345 RYSELTLTGV LQ K SSNV GVSKL AL AMPSSAL V DTY S ---------------- R FGLG KA T NLG L VG E RS G LYPQ K QRWSD 408
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 515 F - LLDY S I G QYDTY TPLQLA QYIS TI ANG G - YR mk P QIVQEIR ----- E QTVQKNE V GK VV QSI E P V V L N ridmkqeyin 587
Cdd:PRK15105 409 I e RATF S F G YGLMV TPLQLA RVYA TI GSY G i YR -- P LSITKVD ppvpg E RVFPESI V RT VV HMM E S V A L P ---------- 476
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446666422 588 qvkegfrkvfqeg D G T GV R A FQ K A p Y KP A G KTGTA QT V YGGENA I GR nakgdrrec Y NLTL AG Y AP YDD P EV A FS VV V 665
Cdd:PRK15105 477 ------------- G G G GV K A AI K G - Y RI A I KTGTA KK V GPDGRY I NK --------- Y IAYT AG V AP ASQ P RF A LV VV I 531
MrcA
COG5009 Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
350-621
1.92e-10
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain]
Cd Length: 785
Bit Score: 64.41
E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 350 A F V VM m N P KN G Q VL SMA G KR lvekdgkmeve D YAL gtlt S SY -------- EL GS TV K ---- G A TVLT G F etnai TP G T HF 417
Cdd:COG5009 424 A L V AL - D P HT G A VL ALV G GF ----------- D FEQ ---- S KF nratqakr QP GS SF K pfvy A A ALDN G Y ----- TP A T II 482
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 418 Y DAP MK F KGTKEKKS W -- KN FGDIDD ---- LR - AL QV S S N VYMFNIALKI a G V DYV KN ssldikqeyfdkmry Y FRQ FG L 490
Cdd:COG5009 483 N DAP IV F DDGGGGGV W rp KN YSGKFY gptt LR e AL EK S R N LVTVRLLQDV - G I DYV ID --------------- Y AER FG I 546
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446666422 491 GVQ tgid LP N etagqigkkdnqpgfll DY S I -- G QYDT y TPL QL A QYISTI ANGGYR MK P QIVQE I reqtvq KNEV GKV V 568
Cdd:COG5009 547 YSK ---- LP P ----------------- NL S L al G SGEV - TPL EM A RAYAVF ANGGYR VE P YLIDR I ------ EDRN GKV I 598
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446666422 569 QSIE P VVLNRIDMKQ E YINQVKEGF ------------------- R K V F Q E G D G TGV RA FQ kapy KP - AGKTGT 621
Cdd:COG5009 599 YRAD P ARACEDCDAA E WDGAEPRLP dpaeqvidprtayqmtsml R G V V Q R G T G RRA RA LG ---- RD i AGKTGT 667
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
