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Conserved domains on  [gi|446669052|ref|WP_000746398|]
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MULTISPECIES: sensor histidine kinase [Bacillus]

Protein Classification

sensor histidine kinase( domain architecture ID 11485193)

two-component system sensor histidine kinase with a PAS sensor and/or ligand binding domain functions as a protein kinase that phosphorylates a target protein in response to various signals, similar to Escherichia coli sensor histidine kinase DcuS and Bacillus subtilis sensor histidine kinase MalK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-534 0e+00

sensory histidine kinase DcuS; Provisional


:

Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 823.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   1 MKKRKRLWNLWKTITLLVCTVVIFSLLVTDILISHNVERATEDSQAEKAKTIAHIVANDSIVINGLVGKADTPAIQTYTN 80
Cdd:PRK11086   7 MKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESGIQTYAE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  81 RILKNTGVQFIVVMDMDGIRKSHPDPQKIGRHFIGGDEGPALKGKEHVSLAEGTLGISMRVFVPIFSETGEQLGAVAVGI 160
Cdd:PRK11086  87 AVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGVVAVGI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 161 SADNVKERVKESRHIIYIGVGVGVLVGIIGAILLARHIKKSLFGLEPHRIAKILEERNTMLQSVKEGIIAVDKEARVTLI 240
Cdd:PRK11086 167 SLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRGEVTLI 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 241 NNEAKRLF-KKSGLEENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGITIVTNRVPLYVKGEIVGAIATFRDKTEI 319
Cdd:PRK11086 247 NDEAKRLFnYKKGLEDDPLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATFRDKTEV 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 320 RKLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGMVSEHQYEIGGVMKRIKSPVFAGFLLGKLSY 399
Cdd:PRK11086 327 RQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISR 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMPEIDDESITHELITIVGNLIDNALEAVTNCEKKQVEIEIQHGD-ILTITVQDTGKGIQEKEIEE 478
Cdd:PRK11086 407 ARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNgWLHCEVSDDGPGIAPDEIDA 486

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446669052 479 LFTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKGRDERQI 534
Cdd:PRK11086 487 IFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-534 0e+00

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 823.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   1 MKKRKRLWNLWKTITLLVCTVVIFSLLVTDILISHNVERATEDSQAEKAKTIAHIVANDSIVINGLVGKADTPAIQTYTN 80
Cdd:PRK11086   7 MKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESGIQTYAE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  81 RILKNTGVQFIVVMDMDGIRKSHPDPQKIGRHFIGGDEGPALKGKEHVSLAEGTLGISMRVFVPIFSETGEQLGAVAVGI 160
Cdd:PRK11086  87 AVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGVVAVGI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 161 SADNVKERVKESRHIIYIGVGVGVLVGIIGAILLARHIKKSLFGLEPHRIAKILEERNTMLQSVKEGIIAVDKEARVTLI 240
Cdd:PRK11086 167 SLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRGEVTLI 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 241 NNEAKRLF-KKSGLEENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGITIVTNRVPLYVKGEIVGAIATFRDKTEI 319
Cdd:PRK11086 247 NDEAKRLFnYKKGLEDDPLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATFRDKTEV 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 320 RKLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGMVSEHQYEIGGVMKRIKSPVFAGFLLGKLSY 399
Cdd:PRK11086 327 RQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISR 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMPEIDDESITHELITIVGNLIDNALEAVTNCEKKQVEIEIQHGD-ILTITVQDTGKGIQEKEIEE 478
Cdd:PRK11086 407 ARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNgWLHCEVSDDGPGIAPDEIDA 486

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446669052 479 LFTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKGRDERQI 534
Cdd:PRK11086 487 IFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
malate_HK_MalK NF038334
malate sensor histidine kinase MalK;
1-526 1.73e-173

malate sensor histidine kinase MalK;


Pssm-ID: 439628 [Multi-domain]  Cd Length: 533  Bit Score: 500.20  E-value: 1.73e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   1 MKKRKRLWNlwkTITLLVCTVVIFSLLVTDILISHNVERATEDSQAEKAKTIAHIVANDSIVINGLVGKADTPAIQTYTN 80
Cdd:NF038334   1 MKKTLKLQT---RLTIFVCIVVLISLCITFFTIGSETAKNIREQERDIALQTAKMVAEAPITAKSLESGKSYKELRQYTT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  81 RILKNTGVQFIVVMDMDGIRKSHPDPQKIGRHFIGGDEGPALKGKEHVSLAEGTLGISMRVFVPIFSETGEQLGAVAVGI 160
Cdd:NF038334  78 RVQKITGTEFVVVMDMNGIRKTHPDPNKIGKKFAGGDEEPALKGHEHISTASGTLGKSMRAFVPVYDKDGKQVGAVAVGI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 161 SADNVKERVKESRHIIYIGVGVGVLVGIIGAILLARHIKKSLFGLEPHRIAKILEERNTMLQSVKEGIIAVDKEARVTLI 240
Cdd:NF038334 158 TLNEIDLIISQSLRPLYFVICLSIFVGIIGAVIVARKVKNIMFGLEPYEIATLLEERSAMLESTKEGILAVDQHGKIKLA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 241 NNEAKRLFKKSGLEENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGITIVTNRVPLYVKGEIVGAIATFRDKTEIR 320
Cdd:NF038334 238 NAEAKRLFHKMGIMTNPIDQDVQDILPKSRLKQVIETKKPLQDRDVRINGLELVFNEVPIHLKGQIVGAIATFRDKTEVK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 321 KLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGMVSEHQYEIGGVMKRIKSPVFAGFLLGKLSYA 400
Cdd:NF038334 318 HLAEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTETSEIINHVKNSVLAGFLLGKQSYI 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 401 REKNIKLIISEDSYMPEIDDESITHELITIVGNLIDNALEAVTNCEKKQVEIEIQHGD-ILTITVQDTGKGIQEKEIEEL 479
Cdd:NF038334 398 REQGATLEVICSTQIPNAADPAVIHDLITVIGNLLNNALDAVSQTEKKNISISFRFHDeQLDIEITDTGVGMSKEEQAKM 477

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 446669052 480 FTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:NF038334 478 FDQGFSTKGQNRGFGLYFVQQSIENLNGHMIVTSEKNEGTTFSLRIP 524
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 210-530 2.22e-104

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 318.33  E-value: 2.22e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 210 IAKILEERNTMLQSVKEGIIAVDKEARVTLINNEAKRLfkksgLEENFIGKDVELYmpnsrIKEVLQTGEVqlNEEQNIY 289
Cdd:COG3290   79 IARLVEEREAVLESIREGVIAVDRDGRITLINDAARRL-----LGLDAIGRPIDEV-----LAEVLETGER--DEEILLN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 290 GITIVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGM 369
Cdd:COG3290  147 GRVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEI 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 370 VSEHQYEIGGVMKRIKSPVFAGFLLGKLSYAREKNIKLIISEDSYMPEIDDESitHELITIVGNLIDNALEAVTNCE--K 447
Cdd:COG3290  227 SEELQELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSD--TDLVTILGNLLDNAIEAVEKLPeeE 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 448 KQVEIEI-QHGDILTITVQDTGKGIQEKEIEELFTKGYSTK-GDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEI 525
Cdd:COG3290  305 RRVELSIrDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384


                 ....*
gi 446669052 526 PKGRD 530
Cdd:COG3290  385 PKEGE 389
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-526 7.22e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 107.37  E-value: 7.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAV--TNCEKKQVEIEI-QHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGD-NRGYGLYLVKESI 502
Cdd:cd16915    1 LITIVGNLIDNALDALaaTGAPNKQVEVFLrDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQgERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 446669052 503 QRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 427-529 6.24e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.59  E-value: 6.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  427 LITIVGNLIDNALEAVTNCEKkqVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKGYS---TKGDNRGYGLYLVKESIQ 503
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGE--ITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....*.
gi 446669052  504 RINGEIHMHSLVGKGTTITIEIPKGR 529
Cdd:pfam02518  84 LLGGTITVESEPGGGTTVTLTLPLAQ 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 427-527 1.17e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 92.71  E-value: 1.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   427 LITIVGNLIDNALEAVTNCEKKQVEIEiQHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNR-----GYGLYLVKES 501
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLE-RDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....*.
gi 446669052   502 IQRINGEIHMHSLVGKGTTITIEIPK 527
Cdd:smart00387  85 VELHGGEISVESEPGGGTTFTITLPL 110
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 215-326 8.30e-06

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 45.36  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  215 EER-NTMLQSVKEGIIAVDKEARVTLINNEAKRLFkksGL-EENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGI- 291
Cdd:TIGR00229   2 EERyRAIFESSPDAIIVIDLEGNILYVNPAFEEIF---GYsAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEe 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 446669052  292 TIVTNR-----------VPLYVKGEIVGAIATFRDKTEIRKLAEEL 326
Cdd:TIGR00229  79 RRVRRKdgseiwvevsvSPIRTNGGELGVVGIVRDITERKEAEEAL 124
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-534 0e+00

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 823.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   1 MKKRKRLWNLWKTITLLVCTVVIFSLLVTDILISHNVERATEDSQAEKAKTIAHIVANDSIVINGLVGKADTPAIQTYTN 80
Cdd:PRK11086   7 MKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESGIQTYAE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  81 RILKNTGVQFIVVMDMDGIRKSHPDPQKIGRHFIGGDEGPALKGKEHVSLAEGTLGISMRVFVPIFSETGEQLGAVAVGI 160
Cdd:PRK11086  87 AVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGVVAVGI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 161 SADNVKERVKESRHIIYIGVGVGVLVGIIGAILLARHIKKSLFGLEPHRIAKILEERNTMLQSVKEGIIAVDKEARVTLI 240
Cdd:PRK11086 167 SLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRGEVTLI 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 241 NNEAKRLF-KKSGLEENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGITIVTNRVPLYVKGEIVGAIATFRDKTEI 319
Cdd:PRK11086 247 NDEAKRLFnYKKGLEDDPLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATFRDKTEV 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 320 RKLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGMVSEHQYEIGGVMKRIKSPVFAGFLLGKLSY 399
Cdd:PRK11086 327 RQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLLGKISR 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMPEIDDESITHELITIVGNLIDNALEAVTNCEKKQVEIEIQHGD-ILTITVQDTGKGIQEKEIEE 478
Cdd:PRK11086 407 ARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNgWLHCEVSDDGPGIAPDEIDA 486

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446669052 479 LFTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKGRDERQI 534
Cdd:PRK11086 487 IFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
malate_HK_MalK NF038334
malate sensor histidine kinase MalK;
1-526 1.73e-173

malate sensor histidine kinase MalK;


Pssm-ID: 439628 [Multi-domain]  Cd Length: 533  Bit Score: 500.20  E-value: 1.73e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   1 MKKRKRLWNlwkTITLLVCTVVIFSLLVTDILISHNVERATEDSQAEKAKTIAHIVANDSIVINGLVGKADTPAIQTYTN 80
Cdd:NF038334   1 MKKTLKLQT---RLTIFVCIVVLISLCITFFTIGSETAKNIREQERDIALQTAKMVAEAPITAKSLESGKSYKELRQYTT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  81 RILKNTGVQFIVVMDMDGIRKSHPDPQKIGRHFIGGDEGPALKGKEHVSLAEGTLGISMRVFVPIFSETGEQLGAVAVGI 160
Cdd:NF038334  78 RVQKITGTEFVVVMDMNGIRKTHPDPNKIGKKFAGGDEEPALKGHEHISTASGTLGKSMRAFVPVYDKDGKQVGAVAVGI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 161 SADNVKERVKESRHIIYIGVGVGVLVGIIGAILLARHIKKSLFGLEPHRIAKILEERNTMLQSVKEGIIAVDKEARVTLI 240
Cdd:NF038334 158 TLNEIDLIISQSLRPLYFVICLSIFVGIIGAVIVARKVKNIMFGLEPYEIATLLEERSAMLESTKEGILAVDQHGKIKLA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 241 NNEAKRLFKKSGLEENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGITIVTNRVPLYVKGEIVGAIATFRDKTEIR 320
Cdd:NF038334 238 NAEAKRLFHKMGIMTNPIDQDVQDILPKSRLKQVIETKKPLQDRDVRINGLELVFNEVPIHLKGQIVGAIATFRDKTEVK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 321 KLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGMVSEHQYEIGGVMKRIKSPVFAGFLLGKLSYA 400
Cdd:NF038334 318 HLAEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKNYDDLGTYIKDIAIYQQTETSEIINHVKNSVLAGFLLGKQSYI 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 401 REKNIKLIISEDSYMPEIDDESITHELITIVGNLIDNALEAVTNCEKKQVEIEIQHGD-ILTITVQDTGKGIQEKEIEEL 479
Cdd:NF038334 398 REQGATLEVICSTQIPNAADPAVIHDLITVIGNLLNNALDAVSQTEKKNISISFRFHDeQLDIEITDTGVGMSKEEQAKM 477

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 446669052 480 FTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:NF038334 478 FDQGFSTKGQNRGFGLYFVQQSIENLNGHMIVTSEKNEGTTFSLRIP 524
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 210-530 2.22e-104

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 318.33  E-value: 2.22e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 210 IAKILEERNTMLQSVKEGIIAVDKEARVTLINNEAKRLfkksgLEENFIGKDVELYmpnsrIKEVLQTGEVqlNEEQNIY 289
Cdd:COG3290   79 IARLVEEREAVLESIREGVIAVDRDGRITLINDAARRL-----LGLDAIGRPIDEV-----LAEVLETGER--DEEILLN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 290 GITIVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGM 369
Cdd:COG3290  147 GRVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQLGEYDEALEYIDEI 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 370 VSEHQYEIGGVMKRIKSPVFAGFLLGKLSYAREKNIKLIISEDSYMPEIDDESitHELITIVGNLIDNALEAVTNCE--K 447
Cdd:COG3290  227 SEELQELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSD--TDLVTILGNLLDNAIEAVEKLPeeE 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 448 KQVEIEI-QHGDILTITVQDTGKGIQEKEIEELFTKGYSTK-GDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEI 525
Cdd:COG3290  305 RRVELSIrDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384


                 ....*
gi 446669052 526 PKGRD 530
Cdd:COG3290  385 PKEGE 389
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 2-527 6.73e-74

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 244.36  E-value: 6.73e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   2 KKRKRLWNLWKT------ITLLVCTVVIFSLLVTDILISHNVERATEDSQAEKAKTIAHIVANDSIVINGlVGKADTPAI 75
Cdd:PRK15053   4 LNENKQFAFFQRlafplrIFLLILVFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIASNDSVISA-VKTRDYKRL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  76 QTYTNRILKNTGVQFIVVMDMDGIRKSHPDPQKIGRHFIGGDEGPALKGKEHVSLAEGTLGISMRVFVPIFSETGEQLGA 155
Cdd:PRK15053  83 ATIANKLQRDTDFDYVVIGDRHSIRLYHPNPEKIGYPMQFTKPGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 156 VAVGISADNVkervkESRHIIYIGVGVGVLVGIIGAILL-----ARHIKKSLFGLEPHRIAKILEERNTMLQSVKEGIIA 230
Cdd:PRK15053 163 VSIGYLVSKI-----DSWRLEFLLPMAGVFVVLLGILMLlswffAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 231 VDKEARVTLINNEAKRLFKKSGLEENFIGKDV-ELYMPNSRIKEvlQTGEVQLNEEQNIYGITIVTNRVPLYVKGEIVGA 309
Cdd:PRK15053 238 VDPHGYITAINRNARKMLGLSSPGRQWLGKPIaEVVRPADFFTE--QIDEKRQDVVANFNGLSVIANREAIRSGDDLLGA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 310 IATFRDKTEIRKLAEELTGIRLYAEALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGMVSEHQYEIGGVMKRIKSPVF 389
Cdd:PRK15053 316 IISFRSKDEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQV 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 390 AGFLLGKLSYAREKNIKLII---SEDSYMPEIDDESithELITIVGNLIDNALEA-VTNCE-KKQVEIEIQ-HGDILTIT 463
Cdd:PRK15053 396 AGLLFGKVQRARELGLKMVIvpgSQLSQLPPGLDST---EFAAIVGNLLDNAFEAsLRSDEgNKIVELFLSdEGDDVVIE 472

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446669052 464 VQDTGKGIQEKEIEELFTKGYSTKGDN---RGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPK 527
Cdd:PRK15053 473 VADQGCGVPESLRDKIFEQGVSTRADEpgeHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPK 539
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 214-531 2.92e-30

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 122.76  E-value: 2.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 214 LEERN----TMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMPNSR----IKEVLQTGEVQLNEE 285
Cdd:COG5000   85 LEERRryleTILENLPAGVIVLDADGRITLANPAAERLLGIP--LEELIGKPLEELLPELDlaelLREALERGWQEEIEL 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 286 QNIYGITIVTNRVPLYVKGEIVgaiaTFRDKTE-------------IRKLAEE----LTGIRLYAEALRaqsHEFMNKMH 348
Cdd:COG5000  163 TRDGRRTLLVRASPLRDDGYVI----VFDDITEllraerlaawgelARRIAHEiknpLTPIQLSAERLR---RKLADKLE 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 349 vvlglthmKQYEELQKYISGMVSEhqyeIGGVMK---------RIKSPVFAGFLLGKL---------SYAREKNIKLIIS 410
Cdd:COG5000  236 --------EDREDLERALDTIIRQ----VDRLKRivdefldfaRLPEPQLEPVDLNELlrevlalyePALKEKDIRLELD 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 411 EDSYMPEID-DEsitHELITIVGNLIDNALEAVTncEKKQVEIEI-QHGDILTITVQDTGKGIQEKEIEELFTKGYSTKG 488
Cdd:COG5000  304 LDPDLPEVLaDR---DQLEQVLINLLKNAIEAIE--EGGEIEVSTrREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP 378

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 446669052 489 DNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKGRDE 531
Cdd:COG5000  379 KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-526 7.22e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 107.37  E-value: 7.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAV--TNCEKKQVEIEI-QHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGD-NRGYGLYLVKESI 502
Cdd:cd16915    1 LITIVGNLIDNALDALaaTGAPNKQVEVFLrDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQgERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 446669052 503 QRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
218-533 2.37e-26

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 110.32  E-value: 2.37e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 218 NTMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMPN-----SRIKEVLQTGEVQLNEEQNIYG-- 290
Cdd:COG3852   10 RAILDSLPDAVIVLDADGRITYVNPAAERLLGLS--AEELLGRPLAELFPEdsplrELLERALAEGQPVTEREVTLRRkd 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 291 ---ITIVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEELtgirLYAEALRAQS-------HEFMNKMHVVLG----LTHM 356
Cdd:COG3852   88 geeRPVDVSVSPLRDAEGEGGVLLVLRDITERKRLEREL----RRAEKLAAVGelaaglaHEIRNPLTGIRGaaqlLERE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 357 KQYEELQKYISGMVSEhqyeiggvMKRIKSpvfagfLLGK-LSYARE--------------------------KNIKLII 409
Cdd:COG3852  164 LPDDELREYTQLIIEE--------ADRLNN------LVDRlLSFSRPrpperepvnlhevlervlellraeapKNIRIVR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 410 SEDSYMPEID-DESithELITIVGNLIDNALEAV---------TNCEKKQVEIEIQHGDILTITVQDTGKGIQEKEIEEL 479
Cdd:COG3852  230 DYDPSLPEVLgDPD---QLIQVLLNLVRNAAEAMpeggtitirTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRI 306

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446669052 480 FTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKGRDERQ 533
Cdd:COG3852  307 FEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEE 360
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 205-331 9.58e-24

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 104.08  E-value: 9.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 205 LEPHRIAKILEernTMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMPNSRIKEVLQTGEVQLNE 284
Cdd:COG3829    4 LELKELEEELE---AILDSLDDGIIVVDADGRITYVNRAAERILGLP--REEVIGKNVTELIPNSPLLEVLKTGKPVTGV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 446669052 285 EQNIYG--ITIVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEELTGIRL 331
Cdd:COG3829   79 IQKTGGkgKTVIVTAIPIFEDGEVIGAVETFRDITELKRLERKLREEEL 127
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 427-529 6.24e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.59  E-value: 6.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  427 LITIVGNLIDNALEAVTNCEKkqVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKGYS---TKGDNRGYGLYLVKESIQ 503
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGE--ITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....*.
gi 446669052  504 RINGEIHMHSLVGKGTTITIEIPKGR 529
Cdd:pfam02518  84 LLGGTITVESEPGGGTTVTLTLPLAQ 109
sCache_3_2 pfam17203
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ...
 38-174 9.35e-23

Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435783 [Multi-domain]  Cd Length: 140  Bit Score: 94.02  E-value: 9.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   38 ERATEDSQAEKAKTIAHIVANDSIVINGLVGKADTPAIQTYTNRILKNTGVQFIVVMDMDGIRKSHPDPQKIGRHFIGGD 117
Cdd:pfam17203   3 RADLTRQLERRALALARSVAASPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSGPA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446669052  118 EGPAL-KGKEHVSLAEGTLGISMRVFVPIFSETGEQLGAVAVGISADNVKERVKESRH 174
Cdd:pfam17203  83 TAPALtAGRSYTGTVTGTLGPSLDAKLPIFDADGRVIGIVSVGVKQDSITAALRELLR 140
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 224-533 9.86e-23

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 101.20  E-value: 9.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 224 VKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMP-------NSRIKEVLQTGEVQLNEEQNIYG----IT 292
Cdd:COG5809  150 SPDGIIVTDLDGRIIYANPAACKLLGIS--IEELIGKSILELIHsddqenvAAFISQLLKDGGIAQGEVRFWTKdgrwRL 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 293 IVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEELTgirlYAEALRAQ-------SHEFMNKMHVVLGLTHMKQ---YEEL 362
Cdd:COG5809  228 LEASGAPIKKNGEVDGIVIIFRDITERKKLEELLR----KSEKLSVVgelaagiAHEIRNPLTSLKGFIQLLKdtiDEEQ 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 363 QKYISGMVSEhqyeiggvMKRIKSPVFAGFLLGKLSYAR--EKNIKLIISE-------DSYMPEIDDESIT-HELITIVG 432
Cdd:COG5809  304 KTYLDIMLSE--------LDRIESIISEFLVLAKPQAIKyePKDLNTLIEEvipllqpQALLKNVQIELELeDDIPDILG 375

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 433 ----------NLIDNALEAVTNCEKKQVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYLVKESI 502
Cdd:COG5809  376 denqlkqvfiNLLKNAIEAMPEGGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKII 455

                        330       340       350
                 ....*....|....*....|....*....|.
gi 446669052 503 QRINGEIHMHSLVGKGTTITIEIPKGRDERQ 533
Cdd:COG5809  456 EEHGGKITVESEVGKGTTFSITLPIKLSEQV 486
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 427-527 1.17e-22

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 92.71  E-value: 1.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052   427 LITIVGNLIDNALEAVTNCEKKQVEIEiQHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNR-----GYGLYLVKES 501
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLE-RDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....*.
gi 446669052   502 IQRINGEIHMHSLVGKGTTITIEIPK 527
Cdd:smart00387  85 VELHGGEISVESEPGGGTTFTITLPL 110
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
211-526 1.36e-21

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 98.50  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 211 AKILEERN---TMLQSVKEGIIAVDKEARVTLINNEAKRLFkksGLEE-NFIGKDV-ELYMPNSRIKEV----LQTGEVQ 281
Cdd:PRK11360 255 QALRETRSlneLILESIADGVIAIDRQGKITTMNPAAEVIT---GLQRhELVGKPYsELFPPNTPFASPlldtLEHGTEH 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 282 L-------NEEQNIygITIVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEELTGI-RLYA--EALRAQSHEFMNKmhvvl 351
Cdd:PRK11360 332 VdleisfpGRDRTI--ELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQeRLAAlgELVAGVAHEIRNP----- 404

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 352 gLTHMKQYEE-LQKYISGmvSEHQYEIGGVMKRIKS--------------------PVFAGFLLGK-LSYARE----KNI 405
Cdd:PRK11360 405 -LTAIRGYVQiWRQQTSD--PPSQEYLSVVLREVDRlnkvidqllefsrpresqwqPVSLNALVEEvLQLFQTagvqARV 481

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 406 KLIISEDSYMPEI--DDESITHELItivgNLIDNALEAVTNCEKKQVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKG 483
Cdd:PRK11360 482 DFETELDNELPPIwaDPELLKQVLL----NILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPF 557

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 446669052 484 YSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK11360 558 FTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
400-528 6.57e-21

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 93.82  E-value: 6.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMPEID-DEsitHELITIVGNLIDNALEAvtNCEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIE 477
Cdd:COG0642  199 AEEKGIELELDLPDDLPTVRgDP---DRLRQVLLNLLSNAIKY--TPEGGTVTVSVRrEGDRVRISVEDTGPGIPPEDLE 273

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446669052 478 ELFTKGYSTKGDNR----GYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKG 528
Cdd:COG0642  274 RIFEPFFRTDPSRRgggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
175-530 7.15e-20

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 91.54  E-value: 7.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 175 IIYIGVGVGVLVGIIGAILLARHIKKSLFGLEPHRIAKILEERNTMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSGLE 254
Cdd:COG5002   14 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 255 ENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGITIVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEE--------- 325
Cdd:COG5002   94 LLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMrrefvanvs 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 326 ------LTGIRLYAEALR-------AQSHEFMNKMHvvlglthmKQYEELQKYISGMVSEHQYEiGGVMKRIKSPVFAGF 392
Cdd:COG5002  174 helrtpLTSIRGYLELLLdgaaddpEERREYLEIIL--------EEAERLSRLVNDLLDLSRLE-SGELKLEKEPVDLAE 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 393 LLGKL-----SYAREKNIKLIISEDSYMPEID-DESithELITIVGNLIDNALEAvtNCEKKQVEIEI-QHGDILTITVQ 465
Cdd:COG5002  245 LLEEVveelrPLAEEKGIELELDLPEDPLLVLgDPD---RLEQVLTNLLDNAIKY--TPEGGTITVSLrEEDDQVRISVR 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446669052 466 DTGKGIQEKEIEELFTKGYST-KGDNR-----GYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKGRD 530
Cdd:COG5002  320 DTGIGIPEEDLPRIFERFYRVdKSRSRetggtGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
326-527 1.35e-19

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 88.04  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 326 LTGIRLYAEALRAQSHEFMNKMHVVLGLTHmKQYEELQKYISGMVSEHQYEiGGVMKRIKSPVFAGFLLGKL-----SYA 400
Cdd:COG2205   31 LTSILGAAELLLDEEDLSPEERRELLEIIR-ESAERLLRLIEDLLDLSRLE-SGKLSLELEPVDLAELLEEAveelrPLA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 401 REKNIKLIISEDSYMPEI--DDESITHelitIVGNLIDNALEAvtNCEKKQVEIEI-QHGDILTITVQDTGKGIQEKEIE 477
Cdd:COG2205  109 EEKGIRLELDLPPELPLVyaDPELLEQ----VLANLLDNAIKY--SPPGGTITISArREGDGVRISVSDNGPGIPEEELE 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446669052 478 ELFTKGYSTKGDNR----GYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPK 527
Cdd:COG2205  183 RIFERFYRGDNSRGeggtGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 427-525 2.30e-18

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 80.34  E-value: 2.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAvtNCEKKQVEIEI-QHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNR----GYGLYLVKES 501
Cdd:cd00075    1 LEQVLSNLLDNALKY--SPPGGTIEISLrQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREgggtGLGLAIVRRI 78

                         90       100
                 ....*....|....*....|....
gi 446669052 502 IQRINGEIHMHSLVGKGTTITIEI 525
Cdd:cd00075   79 VEAHGGRITVESEPGGGTTFTVTL 102
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 209-527 2.20e-17

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 84.78  E-value: 2.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 209 RIAKILEERNTMLQSVKE----GIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMPNS---RIKEVLQtgEVQ 281
Cdd:COG5805  147 KIEEILQEQEERLQTLIEnspdLICVIDTDGRILFINESIERLFGAP--REELIGKNLLELLHPCdkeEFKERIE--SIT 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 282 LNEEQNIYGITIVTNR----------VPLY-VKGEIVGAIATFRDKTEiRKLAEELTgIRLYAEALRAQ-----SHEFMN 345
Cdd:COG5805  223 EVWQEFIIEREIITKDgriryfeaviVPLIdTDGSVKGILVILRDITE-KKEAEELM-ARSEKLSIAGQlaagiAHEIRN 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 346 KMHVVLGLTHMKQ--YEELQKYISGMVSE-------------------HQYEIGGVMKRIKSPVFagfLLGklSYAREKN 404
Cdd:COG5805  301 PLTSIKGFLQLLQpgIEDKEEYFDIMLSEldriesiiseflalakpqaVNKEKENINELIQDVVT---LLE--TEAILHN 375

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 405 IKLIISEDSYMPEID-DESITHELITivgNLIDNALEAVTNCEKKQVEIEIQHGDILtITVQDTGKGIQEKEIEELFTKG 483
Cdd:COG5805  376 IQIRLELLDEDPFIYcDENQIKQVFI---NLIKNAIEAMPNGGTITIHTEEEDNSVI-IRVIDEGIGIPEERLKKLGEPF 451

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 446669052 484 YSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPK 527
Cdd:COG5805  452 FTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 400-526 2.84e-16

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 80.23  E-value: 2.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMPEIddESITHELITIVGNLIDNALEAVTNCEKKQVEIEI-QHGDILTITVQDTGKGIQEKEIEE 478
Cdd:COG4191  232 LKARGIEVELDLPPDLPPV--LGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTrREGDYVVISVRDNGPGIPPEVLER 309

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446669052 479 LFTKGYSTKGDNRGYG--LYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:COG4191  310 IFEPFFTTKPVGKGTGlgLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 396-511 4.75e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 71.84  E-value: 4.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 396 KLSYAREKNIKLII----SEDSYMPEIDdesitheLITIVGNLIDNALEAVTNCEKKQVEIEI---QHGDILTITVQDTG 468
Cdd:cd16935    9 KLELAREKGIEFTIeidiPILLPISPLD-------LCIIFGNLLDNAIEACAKIDKENRFIHLkirQKKGFLIISIENSY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446669052 469 KGiqekEIEELFTKGYSTKGD-NRGYGLYLVKESIQRINGEIHM 511
Cdd:cd16935   82 EG----ELKKKNGLFLSTKKDkNHGIGLKSIREIVKKYNGNLSI 121
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 398-526 1.22e-13

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 72.59  E-value: 1.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 398 SYAREKNIKLIIS-EDSYMPEIDDESITHELItivgNLIDNALEAVTNCEKKQVEIEIQHGDILtITVQDTGKGIQEKEI 476
Cdd:COG5806  286 PYANMNNVEIQTElEPGLYIEGDRQKLQQCLI----NIIKNGIEAMPNGGTLTIDVSIDKNKVI-ISIKDTGVGMTKEQL 360

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446669052 477 EELFTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:COG5806  361 ERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
417-530 1.32e-13

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 72.74  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 417 EID-DESITHELI--TIVGNLIDNALEAVTNCEKKQVEIEI---QHGDILTITVQDTGKGIQEKEIEELFtKGYSTKGDN 490
Cdd:COG2972  324 EIEiDEELLDLLIpkLILQPLVENAIEHGIEPKEGGGTIRIsirKEGDRLVITVEDNGVGMPEEKLEKLL-EELSSKGEG 402

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446669052 491 RGYGLYLVKESIQRINGE---IHMHSLVGKGTTITIEIPKGRD 530
Cdd:COG2972  403 RGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 426-526 2.03e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 63.60  E-value: 2.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 426 ELITIVGNLIDNALEAVTncEKKQVEIEI-QHGDILTITVQDTGKGIQEKEIEELFTKGYSTK--GDNRGYGLYLVKESI 502
Cdd:cd16943    3 QLNQVLLNLLVNAAQAME--GRGRITIRTwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRII 80

                         90       100
                 ....*....|....*....|....
gi 446669052 503 QRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16943   81 QKHGGTIRVASVPGGGTRFTIILP 104
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
400-526 2.42e-12

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 69.04  E-value: 2.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMPEI--DDESITHELItivgNLIDNALEAVTNCEKKQVEIEiQHGDILTITVQDTGKGIQEKEIE 477
Cdd:PRK10364 324 ANSREIQLRFTANDTLPEIqaDPDRLTQVLL----NLYLNAIQAIGQHGVISVTAS-ESGAGVKISVTDSGKGIAADQLE 398

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 446669052 478 ELFTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK10364 399 AIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 433-526 2.86e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 63.18  E-value: 2.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 433 NLIDNALEAVT--NCEKKQVEI--EIQHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYLVKESIQRINGE 508
Cdd:cd16920    7 NLVRNGIEAMSegGCERRELTIrtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGR 86

                         90
                 ....*....|....*...
gi 446669052 509 IHMHSLVGKGTTITIEIP 526
Cdd:cd16920   87 LSVESPAGGGATFQFTLP 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 430-526 1.20e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 61.35  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 430 IVGNLIDNAL------EAVTNCekkQVEIEIQHGDILTITVQDTGKGIQEKEIEELFTK------GYSTKGDNRGYGLYL 497
Cdd:cd16922    4 ILLNLLGNAIkfteegEVTLRV---SLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPfsqadsSTTRKYGGTGLGLAI 80

                         90       100
                 ....*....|....*....|....*....
gi 446669052 498 VKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16922   81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-526 2.02e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 60.76  E-value: 2.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEavTNCEKKQVEIEIQH-GDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNR-----GYGLYLVKE 500
Cdd:cd16948    6 LSFIIGQIVSNALK--YSKQGGKIEIYSETnEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNfqestGMGLYLVKK 83

                         90       100
                 ....*....|....*....|....*.
gi 446669052 501 SIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16948   84 LCDKLGHKIDVESEVGEGTTFTITFP 109
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 401-527 1.94e-10

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 63.27  E-value: 1.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 401 REKNIKLIISEdsyMPEID-DESithELITIVGNLIDNALEAVTNCEKKQVEIE-IQHGDILTITVQDTGKGIQEKEIEE 478
Cdd:COG4251  374 EERGAEIEVGP---LPTVRgDPT---LLRQVFQNLISNAIKYSRPGEPPRIEIGaEREGGEWVFSVRDNGIGIDPEYAEK 447

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446669052 479 LFTKGYSTKGDNR----GYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPK 527
Cdd:COG4251  448 IFEIFQRLHSRDEyegtGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 400-526 2.89e-10

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 63.04  E-value: 2.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMP---EIDDEsithELITIVGNLIDNAleaVTNCEKKQVEIEIQH--GDILTITVQDTGKGIQEK 474
Cdd:PRK11091 373 AEQKGLRFDLEPLLPLPhkvITDGT----RLRQILWNLISNA---VKFTQQGGVTVRVRYeeGDMLTFEVEDSGIGIPED 445

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446669052 475 EIEELFTKGYSTKG--DNR-----GYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK11091 446 ELDKIFAMYYQVKDshGGKpatgtGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 440-526 5.46e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 56.02  E-value: 5.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 440 EAVTNCEK----KQVEIEIQH-GDILTITVQDTGKGIQEkeieelftkgySTKGDNRGYGLYLVKESIQRINGEIHMHSL 514
Cdd:cd16917    7 EALTNALKhagaSRVRVTLSYtADELTLTVVDDGVGFDG-----------PAPPGGGGFGLLGMRERAELLGGTLTIGSR 75

                         90
                 ....*....|..
gi 446669052 515 VGKGTTITIEIP 526
Cdd:cd16917   76 PGGGTRVTARLP 87
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
400-526 6.71e-10

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 62.06  E-value: 6.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  400 AREKNIKLIISE---DSYMPEIDDESITHELITIVGNLIDNALEAVTNCEKKQVEIEIQHGdILTITVQDTGKGIQEKEI 476
Cdd:PRK09959  803 AASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDNHA-VIKMTIMDSGSGLSQEEQ 881

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446669052  477 EELFtKGYSTKGDNR-----GYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK09959  882 QQLF-KRYSQTSAGRqqtgsGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 425-510 1.83e-09

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 54.91  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  425 HELITIVGNLIDNALEAVTNCEK-KQVEIEI-QHGDILTITVQDTGKGiQEKEIEELFTKgySTKGDNRGYGLYLVKESI 502
Cdd:pfam14501   4 VDLCVIFGNLLDNAIEACSKIDDnRFIRLKIrEKQNFLIIRIENTYEG-ELKFEGKLPST--KTKGDGHGIGLKSIRRIV 80


                  ....*...
gi 446669052  503 QRINGEIH 510
Cdd:pfam14501  81 KKYGGNLS 88
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
309-526 5.47e-09

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 58.92  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 309 AIATFRDKTEIRKLAEELTGI--RL-YAEALRAQ-------SHEFMNKMHVVLGLTHMKQYEE-----LQKYISGMVS-- 371
Cdd:PRK13837 417 ALDCLAHAIERRRLETERDALerRLeHARRLEAVgtlasgiAHNFNNILGAILGYAEMALNKLarhsrAARYIDEIISag 496

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 372 EHQYEI-------GGVMKRIKSPVFAGFLLGK----LSYAREKNIKLIISEDSYMPEIDDESIthELITIVGNLIDNALE 440
Cdd:PRK13837 497 ARARLIidqilafGRKGERNTKPFDLSELVTEiaplLRVSLPPGVELDFDQDQEPAVVEGNPA--ELQQVLMNLCSNAAQ 574

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 441 AVTncEKKQVEI-----------EIQH-----GDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYLVKESIQR 504
Cdd:PRK13837 575 AMD--GAGRVDIslsraklrapkVLSHgvlppGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSA 652

                        250       260
                 ....*....|....*....|..
gi 446669052 505 INGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK13837 653 HAGYIDVQSTVGRGTRFDVYLP 674
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 388-526 1.40e-08

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 54.51  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 388 VFAGF--LLGKLSYAREKNIKLIIS-EDSympEIDD---ESITHELITIVGNLIDNALEAVTNCEKK------QVEIEIQ 455
Cdd:cd16916    1 VFSRFprLVRDLARELGKQVELVVEgEDT---ELDKsvlEKLADPLTHLLRNAVDHGIEAPEERLAAgkppegTITLRAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 456 H-GDILTITVQDTGKGIQ-----------------------EKEIEEL-FTKGYSTKGD-----NRGYGLYLVKESIQRI 505
Cdd:cd16916   78 HqGNQVVIEVSDDGRGIDrekirekaierglitadeaatlsDDEVLNLiFAPGFSTAEQvtdvsGRGVGMDVVKRSIESL 157

                        170       180
                 ....*....|....*....|.
gi 446669052 506 NGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16916  158 GGTIEVESEPGQGTTFTIRLP 178
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
440-526 1.59e-08

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 55.78  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 440 EAVTNCEK----KQVEIEI-QHGDILTITVQDTGKGIQEKEIEElftkgystkgdnRGYGLYLVKESIQRINGEIHMHSL 514
Cdd:COG4585  169 EALTNALKhagaTRVTVTLeVDDGELTLTVRDDGVGFDPEAAPG------------GGLGLRGMRERAEALGGTLTIGSA 236

                         90
                 ....*....|..
gi 446669052 515 VGKGTTITIEIP 526
Cdd:COG4585  237 PGGGTRVRATLP 248
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-523 1.94e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 52.41  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 431 VGNLIDNALEAVTncEKKQVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKGY---STKGDNRGYGLYLVKESIQRING 507
Cdd:cd16940   18 LRNLVDNAVRYSP--QGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVKRIVELHGG 95

                         90
                 ....*....|....*.
gi 446669052 508 EIHMHSLVGKGTTITI 523
Cdd:cd16940   96 QIFLGNAQGGGLEAWV 111
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 430-526 2.88e-08

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 51.72  E-value: 2.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 430 IVGNLIDNALEAVTNCEKKQVEIEIQHGDILTITVQDTGKGI---QEKEIEELFTKGYSTKGDNR---GYGLYLVKESIQ 503
Cdd:cd16925    8 VVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIppnLREEIFERFRQGDGSSTRAHggtGLGLSIVKEFVE 87

                         90       100
                 ....*....|....*....|...
gi 446669052 504 RINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16925   88 LHGGTVTVSDAPGGGALFQVELP 110
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 433-526 3.03e-08

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 52.00  E-value: 3.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 433 NLIDNALEAVTNCEKKQVEIEIQH--------------GDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYL- 497
Cdd:cd16919    7 NLAVNARDAMPEGGRLTIETSNQRvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLs 86

                         90       100       110
                 ....*....|....*....|....*....|
gi 446669052 498 -VKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16919   87 mVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 430-526 1.64e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 49.37  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 430 IVGNLIDNALeavtNCEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIEEL---FTKGYSTKG-DNRGYGLYLVKESIQR 504
Cdd:cd16950    4 VLSNLVDNAL----RYGGGWVEVSSDgEGNRTRIQVLDNGPGIAPEEVDELfqpFYRGDNARGtSGTGLGLAIVQRISDA 79

                         90       100
                 ....*....|....*....|..
gi 446669052 505 INGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16950   80 HGGSLTLANRAGGGLCARIELP 101
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-526 1.89e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 49.25  E-value: 1.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAVTNCEKKQVEI-EIQHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNR----GYGLYLVKES 501
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRRPPRIEVgAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEyegtGVGLAIVRKI 80

                         90       100
                 ....*....|....*....|....*
gi 446669052 502 IQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16921   81 IERHGGRIWLESEPGEGTTFYFTLP 105
PRK15347 PRK15347
two component system sensor kinase;
430-526 3.60e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 53.11  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 430 IVGNLIDNAleaVTNCEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYLvkeSIQR---- 504
Cdd:PRK15347 517 ILVNLLGNA---VKFTETGGIRLRVKrHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGL---TIASslak 590

                         90       100
                 ....*....|....*....|...
gi 446669052 505 -INGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK15347 591 mMGGELTLFSTPGVGSCFSLVLP 613
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 425-516 4.11e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 49.17  E-value: 4.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 425 HELITIVGNLIDNAleavtnCE--KKQVEIEIQHGD-ILTITVQDTGKGIQEKEIEELFTKGysTKGDNR----GYGLYL 497
Cdd:cd16954   36 NDLMELLGNLLDNA------CKwcLEFVEVTARQTDgGLHLIVDDDGPGVPESQRSKIFQRG--QRLDEQrpgqGLGLAI 107

                         90       100
                 ....*....|....*....|
gi 446669052 498 VKESIQRINGEIHM-HSLVG 516
Cdd:cd16954  108 AKEIVEQYGGELSLsDSPLG 127
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
449-526 8.34e-07

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 51.72  E-value: 8.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 449 QVEIEIQH-GDILTITVQDTGKGIQ-----------------------EKEIEEL-FTKGYSTK-------GdnRGYGLY 496
Cdd:COG0643  310 TITLSAYHeGGRVVIEVSDDGRGLDlekirakaiekglitaeeaaalsDEELLELiFAPGFSTAeevtdlsG--RGVGMD 387

                         90       100       110
                 ....*....|....*....|....*....|
gi 446669052 497 LVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:COG0643  388 VVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 431-529 9.94e-07

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 51.38  E-value: 9.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 431 VGNLIDNALEaVTNcEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIEELFTKGYST-KGDNR----GYGLYLVKESIQR 504
Cdd:PRK11100 373 LGNLLDNAID-FSP-EGGTITLSAEvDGEQVALSVEDQGPGIPDYALPRIFERFYSLpRPANGrkstGLGLAFVREVARL 450

                         90       100
                 ....*....|....*....|....*
gi 446669052 505 INGEIHMHSLVGKGTTITIEIPKGR 529
Cdd:PRK11100 451 HGGEVTLRNRPEGGVLATLTLPRHF 475
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-497 1.23e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 47.07  E-value: 1.23e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446669052 427 LITIVGNLIDNALEAVTNCEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYL 497
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVENPRIRIAARrLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGL 72
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 423-532 1.89e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 50.29  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 423 ITHELITivgnlidNALE-AVTNCEKKQVEIEIQ-HGDILTITVQDTGKGIQEKeieelftkgySTKGDNRGYGLYLVKE 500
Cdd:COG3920  403 ILNELVT-------NALKhAFLSGEGGRIRVSWRrEDGRLRLTVSDNGVGLPED----------VDPPARKGLGLRLIRA 465

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446669052 501 SIQRINGEIHMHSlvGKGTTITIEIPKGRDER 532
Cdd:COG3920  466 LVRQLGGTLELDR--PEGTRVRITFPLAELAA 495
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-526 2.20e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 46.41  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAVTNCEKKQVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKGYSTK------GDNRGYGLYLVKE 500
Cdd:cd16953    1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERpaneafGQHSGLGLSISRQ 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 446669052 501 SIQ----RINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16953   81 IIEahggISVAENHNQPGQVIGARFTVQLP 110
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
420-526 3.92e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 46.06  E-value: 3.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 420 DESITHELITIVGNLIDNALE-AVTNCEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIEElftkGYSTKGDnRGYGLYL 497
Cdd:COG2172   28 DEDDADDLVLAVSEAVTNAVRhAYGGDPDGPVEVELElDPDGLEIEVRDEGPGFDPEDLPD----PYSTLAE-GGRGLFL 102

                         90       100
                 ....*....|....*....|....*....
gi 446669052 498 VKesiqRINGEIHMHSLVGkGTTITIEIP 526
Cdd:COG2172  103 IR----RLMDEVEYESDPG-GTTVRLVKR 126
SPOB_a pfam14689
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B ...
 334-372 6.13e-06

Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.


Pssm-ID: 434130 [Multi-domain]  Cd Length: 62  Bit Score: 43.78  E-value: 6.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 446669052  334 EALRAQSHEFMNKMHVVLGLTHMKQYEELQKYISGMVSE 372
Cdd:pfam14689  14 KALRHQRHDFLNHLQVISGYLQLGRYDRAEEYIKEVVKD 52
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 430-526 7.04e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 44.74  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 430 IVGNLIDNALE------AVTNCEKKQveieiqhGDILTITVQDTGKGIQEKEIEELFTKgySTKGdnRGYGLYLVKESIQ 503
Cdd:cd16924    9 LVENAIQHGLSpltdkgVVTISALKE-------DNHVMIEVEDNGRGIDPKVLNILGKK--PKEG--NGIGLYNVHQRLI 77

                         90       100
                 ....*....|....*....|....*.
gi 446669052 504 RINGE---IHMHSLVGKGTTITIEIP 526
Cdd:cd16924   78 LLFGEdygIHIASEPDKGTRITFTIP 103
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 215-326 8.30e-06

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 45.36  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  215 EER-NTMLQSVKEGIIAVDKEARVTLINNEAKRLFkksGL-EENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQNIYGI- 291
Cdd:TIGR00229   2 EERyRAIFESSPDAIIVIDLEGNILYVNPAFEEIF---GYsAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEe 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 446669052  292 TIVTNR-----------VPLYVKGEIVGAIATFRDKTEIRKLAEEL 326
Cdd:TIGR00229  79 RRVRRKdgseiwvevsvSPIRTNGGELGVVGIVRDITERKEAEEAL 124
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 215-315 9.06e-06

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 44.72  E-value: 9.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  215 EERNTMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMPN-------SRIKEVLQTGEVQLNEEQN 287
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLS--REEVIGKSLLDLIPEeddaevaELLRQALLQGEESRGFEVS 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446669052  288 I-----YGITIVTNRVPLY-VKGEIVGAIATFRD 315
Cdd:pfam00989  79 FrvpdgRPRHVEVRASPVRdAGGEILGFLGVLRD 112
PRK10547 PRK10547
chemotaxis protein CheA; Provisional
 431-526 1.32e-05

chemotaxis protein CheA; Provisional


Pssm-ID: 236712 [Multi-domain]  Cd Length: 670  Bit Score: 47.80  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 431 VGNLIDNAleavtncekkqveiEIQHGDIlTITVQDTGKGIQEKEI-----------------EE----LFTKGYSTKG- 488
Cdd:PRK10547 416 VGNLILSA--------------EHQGGNI-CIEVTDDGAGLNRERIlakaasqglavsenmsdEEvgmlIFAPGFSTAEq 480

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446669052 489 ----DNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK10547 481 vtdvSGRGVGMDVVKRNIQEMGGHVEIQSKQGKGTTIRILLP 522
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 398-526 1.72e-05

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 47.37  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 398 SYAREKNIKLIISEDSyMPEIDDESITHELItivgNLIDNALEAVTncEKKQVEIEIQ-HGDILTITVQDTGKGIQEkeI 476
Cdd:COG4192  520 SRAKPQQITLHIPDDL-MVQGDQVLLEQVLV----NLLVNALDAVA--TQPQISVDLLsNAENLRVAISDNGNGWPL--V 590

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446669052 477 EELFTKGYSTKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:COG4192  591 DKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
HATPase_TopVIB-like cd16933
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
 427-491 2.52e-05

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.


Pssm-ID: 340410 [Multi-domain]  Cd Length: 203  Bit Score: 45.42  E-value: 2.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446669052 427 LITIVGNLIDNALEAvtnCEKK------QVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKG-YSTKGDNR 491
Cdd:cd16933   20 LYTTVRELVENSLDA---TEEAgilpdiKVEIEEIGKDHYKVIVEDNGPGIPEEQIPKVFGKVlYGSKYHNK 88
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-509 2.75e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.22  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 431 VGNLIDNALEAVTNCEKKQVEIEIQHGDIlTITVQDTGKGIQEKEIEELFTKGYS-----TKGDNRGYGLYLVKESIQRI 505
Cdd:cd16945    9 INNLLDNAIDFSPEGGLIALQLEADTEGI-ELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQLH 87


                 ....
gi 446669052 506 NGEI 509
Cdd:cd16945   88 GGRI 91
PAS COG2202
PAS domain [Signal transduction mechanisms];
206-338 3.52e-05

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 45.40  E-value: 3.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 206 EPHRIAKILEERNTMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMPNS-------RIKEVLQTG 278
Cdd:COG2202    2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYS--AEELLGKTLRDLLPPEdddefleLLRAALAGG 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446669052 279 EVQLNEEQNIY----GITIVTNRVPLY-VKGEIVGAIATFRDKTEiRKLAEELtgIRLYAEALRA 338
Cdd:COG2202   80 GVWRGELRNRRkdgsLFWVELSISPVRdEDGEITGFVGIARDITE-RKRAEEA--LRESEERLRL 141
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
369-509 3.54e-05

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 46.55  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 369 MVSEHqyeigGVMKRIKSPVFAgfLLGKLSYAREK-------NIKLIIS-EDSYMPEIDDesitheLITIVGNLIDNA-- 438
Cdd:PRK10815 326 MRSEH-----NLLSRELHSVAP--LLDNLTSALNKvyqrkgvNITLDISpEITFVGEKND------FMEVMGNVLDNAck 392

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446669052 439 --LEAVtncekkqvEIEIQHGD-ILTITVQDTGKGIQEKEIEELFTKGysTKGDN----RGYGLYLVKESIQRINGEI 509
Cdd:PRK10815 393 ycLEFV--------EISARQTDeHLHIVVEDDGPGIPESKRELIFDRG--QRADTlrpgQGLGLSVAREITEQYEGKI 460
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-526 4.36e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 42.80  E-value: 4.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 434 LIDNAL-----EAVTNCEKKQVEIEIQHGdiLTITVQDTGKGIQEKEIEELftkGYSTKGDNRGYGLYLVKESiQRING- 507
Cdd:cd16957    9 LVENAIrhafpKRKENNEVRVVVKKDQHK--VHVSVSDNGQGIPEERLDLL---GKTTVTSEKGTGTALENLN-RRLIGl 82

                         90       100
                 ....*....|....*....|....
gi 446669052 508 -----EIHMHSLVGKGTTITIEIP 526
Cdd:cd16957   83 fgseaCLHIESEVHGGTEVWFVIP 106
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 462-529 4.70e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 42.57  E-value: 4.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446669052 462 ITVQDTGKGIQEKEIEELFTKGY------STKGDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIPKGR 529
Cdd:cd16952   35 LSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHVMSRHDARLLIASELGKGSRFTCLFPSSR 108
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-526 2.44e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 40.46  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAVtncEKKQVEIEIQ-------------HGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGY 493
Cdd:cd16918    1 LIQVFLNLVRNAAQAL---AGSGGEIILRtrtqrqvtlghprHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGL 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446669052 494 GLYLVKESIQRINGEIHMHSLVGKgTTITIEIP 526
Cdd:cd16918   78 GLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 400-526 2.56e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 44.07  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 400 AREKNIKLIISEDSYMPE--IDDesiTHELITIVGNLIDNALEaVTncEKKQVEIEIQHGDI------LTITVQDTGKGI 471
Cdd:PRK11107 383 AHEKGLELTLNIDPDVPDnvIGD---PLRLQQIITNLVGNAIK-FT--ESGNIDILVELRALsntkvqLEVQIRDTGIGI 456

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446669052 472 QEKEIEELF----------TKGYStkgdnrGYGLYLV--KESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK11107 457 SERQQSQLFqafrqadasiSRRHG------GTGLGLVitQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 221-318 4.50e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 39.70  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052  221 LQSVKEGIIAVDKEARVTLINNEAKRLFKKSGleENFIGK-DVELYMPNSR------IKEVLQTGEVQLNEEQNIYG--- 290
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPP--EELLGKtLAELLPPEDAarleraLRRALEGEEPIDFLEELLLNgee 78

                          90       100
                  ....*....|....*....|....*....
gi 446669052  291 ITIVTNRVPLY-VKGEIVGAIATFRDKTE 318
Cdd:pfam08448  79 RHYELRLTPLRdPDGEVIGVLVISRDITE 107
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 433-526 5.21e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 39.83  E-value: 5.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 433 NLIDNALEAVTNCEKKQVEIEI-----QHGDIlTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYLVKESIQRING 507
Cdd:cd16944   11 NILKNAAEAIEGRPSDVGEVRIrveadQDGRI-VLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEEHGG 89

                         90
                 ....*....|....*....
gi 446669052 508 EIHMHSLVGKGTTITIEIP 526
Cdd:cd16944   90 RISLSNREAGGACIRIILP 108
PAS COG2202
PAS domain [Signal transduction mechanisms];
215-326 5.91e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 41.93  E-value: 5.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 215 EER-NTMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMP-------NSRIKEVLQTGEVQLNEE- 285
Cdd:COG2202  136 EERlRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYS--PEELLGKSLLDLLHpedrerlLELLRRLLEGGRESYELEl 213

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446669052 286 ----QNIYGITIVTNRVPLYVKGEIVGAIATFRDKTEIRKLAEEL 326
Cdd:COG2202  214 rlkdGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-526 7.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 39.37  E-value: 7.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAVTNCEKKQVEIEiQHGDILTITVQDTGKGIQEKEIEELFTKGYSTKGD-NR-----GYGLYLVKE 500
Cdd:cd16946    5 LQQLFVNLLENSLRYTDTGGKLRIRAA-QTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrNRasggsGLGLAICHN 83

                         90       100
                 ....*....|....*....|....*..
gi 446669052 501 SIQRINGEIHM-HSLVGkGTTITIEIP 526
Cdd:cd16946   84 IALAHGGTISAeHSPLG-GLRLVLTLP 109
PRK04184 PRK04184
DNA topoisomerase VI subunit B; Validated
 427-487 1.28e-03

DNA topoisomerase VI subunit B; Validated


Pssm-ID: 235246 [Multi-domain]  Cd Length: 535  Bit Score: 41.42  E-value: 1.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAvtnCE--------KKQVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKG-YSTK 487
Cdd:PRK04184  37 LYTTVKELVDNSLDA---CEeagilpdiKIEIKRVDEGKDHYRVTVEDNGPGIPPEEIPKVFGKLlYGSK 103
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-526 1.57e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 38.21  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 434 LIDNAL-EAVTNCEKKQV---EIEIQHGDILTITVQDTGKGIQEKEIEELftkgYSTKGDNRGYGLYLVKESIQRING-E 508
Cdd:cd16955    9 LVENAIvHGIQEKKGKGVvkiSVKKQLKNRLHIAVEDNGIGISPKVIERV----EQDEMPGNKIGLLNVHQRLKLGYGeG 84

                         90
                 ....*....|....*...
gi 446669052 509 IHMHSLVGKGTTITIEIP 526
Cdd:cd16955   85 LHIRSRPDPGTLIAFYIP 102
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 409-526 1.76e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 39.25  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 409 ISEDSYMPEIDDESITHELITIV----------GNLIDNALEAV------TNCEKKQVEIEIQHGDI-LTITVQDTGKGI 471
Cdd:cd16929   16 LCDDYYLSSPELEIEGDPSIRFPyvpshlyyilFELLKNAMRATveshgdDSDDLPPIKVTVAKGDEdLTIKISDRGGGI 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446669052 472 QEKEIEELFTKGYSTK----GDNR---------------GYGLYLVKESIQRINGEIHMHSLVGKGTTITIEIP 526
Cdd:cd16929   96 PREDLARLFSYMYSTApqpsLDDFsdlisgtqpsplagfGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 427-525 1.79e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 38.21  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAVTncEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIE---ELFTKG--YSTKGDNRGYGLYLVKE 500
Cdd:cd16975    5 LSRALINIISNACQYAP--EGGTVSISIYdEEEYLYFEIWDNGHGFSEQDLKkalELFYRDdtSRRSGGHYGMGLYIAKN 82

                         90       100
                 ....*....|....*....|....*
gi 446669052 501 SIQRINGEIHMHSLVGKGTTITIEI 525
Cdd:cd16975   83 LVEKHGGSLIIENSQKGGAEVTVKI 107
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 430-525 1.96e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 38.26  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 430 IVGNLIDNALEAVTNCEKKQVEIEIQHGDILtITVQDTGKGIQEKEIEELFTKGYsTKGDNR-------GYGLYLVKESI 502
Cdd:cd16947   24 ILKNLISNAIKYGSDGKFLGMTLREDEKHVY-IDIWDKGKGISETEKDHVFERLY-TLEDSRnsakqgnGLGLTITKRLA 101

                         90       100
                 ....*....|....*....|...
gi 446669052 503 QRINGEIHMHSLVGKGTTITIEI 525
Cdd:cd16947  102 ESMGGSIYVNSKPYEKTVFTVTL 124
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
430-526 2.30e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 40.73  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 430 IVGNLIDNALEAV-TNCEKKQVEIeiqHGDILTITVQDTGKGIQEKEIEELF------TKGYSTKGDNRGYGLYLVKESI 502
Cdd:PRK10841 566 VISNLLSNAIKFTdTGCIVLHVRV---DGDYLSFRVRDTGVGIPAKEVVRLFdpffqvGTGVQRNFQGTGLGLAICEKLI 642

                         90       100
                 ....*....|....*....|....
gi 446669052 503 QRINGEIHMHSLVGKGTTITIEIP 526
Cdd:PRK10841 643 NMMDGDISVDSEPGMGSQFTIRIP 666
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
440-499 3.59e-03

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 37.65  E-value: 3.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446669052  440 EAVTN--------CEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIEELFTKGYSTKGDNRGYGLYLVK 499
Cdd:pfam13581  38 EACTNavehayreGPEGPVEVRLTsDGGGLVVTVADSGPPFDPLTLPPPDLEEPDEDRKEGGRGLALIR 106
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
427-526 4.04e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 39.92  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 427 LITIVGNLIDNALEAvtncEKKQVEIEIQ-HGDILTITVQDTGKGIQEKEIEELFTKGY--STKGDNR----GYGLYLVK 499
Cdd:PRK09470 354 LASALENIVRNALRY----SHTKIEVAFSvDKDGLTITVDDDGPGVPEEEREQIFRPFYrvDEARDREsggtGLGLAIVE 429

                         90       100
                 ....*....|....*....|....*...
gi 446669052 500 ESIQRINGEIH-MHSLVGkGTTITIEIP 526
Cdd:PRK09470 430 NAIQQHRGWVKaEDSPLG-GLRLTIWLP 456
PRK13560 PRK13560
hypothetical protein; Provisional
 209-334 4.52e-03

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 40.04  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 209 RIAKILEERNTMLQSVKE----GIIAVDKEARVTLINNEAKRLF---------------KKSGLEENFIGKDVELYMPNS 269
Cdd:PRK13560 322 AAERELLEKEDMLRAIIEaapiAAIGLDADGNICFVNNNAAERMlgwsaaevmgkplpgMDPELNEEFWCGDFQEWYPDG 401

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 270 RIK--------------EVLQTGEVQLNEEQNIYgITIVTNRVPLY-VKGEIVGAIATFRDKTEIRKLAEELTGIRLYAE 334
Cdd:PRK13560 402 RPMafdacpmaktikggKIFDGQEVLIEREDDGP-ADCSAYAEPLHdADGNIIGAIALLVDITERKQVEEQLLLANLIVE 480
TyrR COG3283
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ...
 216-351 5.73e-03

Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];


Pssm-ID: 442513 [Multi-domain]  Cd Length: 514  Bit Score: 39.40  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 216 ERNTMLQSVKEGIIAVDKEARVTLINNEAKRLFKKSglEENFIGKDVELYMPNSRIKEVLQTGEVQLNEEQ-NIYGITIV 294
Cdd:COG3283   81 ELDALLEALPDPVFSIDLKGKIELANPAALSLLGLS--EEELIGQPLSELLKGFNFSRWLESNEPRPQSERvVINGQDYL 158

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446669052 295 TNRVPLYV-----KGEIVGAIATFrdKTEIRklaeelTGIRLYA---------EALRAQShefmNKMHVVL 351
Cdd:COG3283  159 ADILPIYLpdeegKSILAGAVVTL--KSAAR------LGEQLQAlqvnddsgfDHIVASS----PKMRQVI 217
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 434-487 5.95e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 37.31  E-value: 5.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 446669052  434 LIDNALEAvtNCEKKQVEIEIQHGDILTITVQDTGKGIQEKEIEELFTKGYSTK 487
Cdd:pfam13589   8 LIDNSIDA--DATNIKIEVNKNRGGGTEIVIEDDGHGMSPEELINALRLATSAK 59
PRK10618 PRK10618
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
 450-526 6.04e-03

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional


Pssm-ID: 236726 [Multi-domain]  Cd Length: 894  Bit Score: 39.53  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446669052 450 VEIEIQHGDILTITVQDTGKGIQEKEIEEL----FTKGYSTK-GDNRGYGLYLVKESIQRINGEIHMHSLVGKGTTITIE 524
Cdd:PRK10618 590 VDQDESSPDRLTIRILDTGAGVSIKELDNLhfpfLNQTQGDRyGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIH 669


                 ..
gi 446669052 525 IP 526
Cdd:PRK10618 670 LK 671
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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