|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
7-383 |
3.65e-106 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 318.01 E-value: 3.65e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 7 NPWLVVLGTVIVQMGLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGL 86
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 87 GLVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAF 166
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 167 IYWGLIVTAMIVLGACLIHQAADQGAVQETN---------THEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIG 237
Cdd:cd17353 161 LILGIIFLIIIVIGAFLIRDPPKGWVPPGVDplannaensPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 238 VQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGN 317
Cdd:cd17353 241 QEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGG 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446671570 318 ITIFPAIVGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALL---GGFKPTFMVIGVLCVVSFIIAILI 383
Cdd:cd17353 321 FALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVlytGGYNAAFIIAAALSLVALALALLL 389
|
|
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
8-379 |
1.69e-74 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 236.57 E-value: 1.69e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 8 PWLVVLGTVIVQMGLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLG 87
Cdd:TIGR00890 2 WWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 88 LVLSSQASSLILLYILAGVVvGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFI 167
Cdd:TIGR00890 82 FTFYAIADSLAALYLTYGLA-SAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPAAFI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 168 YWGLIVTAMIVLGACLIHQAADQGAVQ--ETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLvGLSA 245
Cdd:TIGR00890 161 YMGIIFLLVIVLGAFLIGYPPGQLIKTniEVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSL-GLSD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 246 ATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFV-DLNYGIYFVCVASVAFCFGGNITIFPAI 324
Cdd:TIGR00890 240 GFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIpMLNDVLFLATVALVFFTWGGTISLFPSL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446671570 325 VGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALL---GGFKPTFMVIGVLCVVSFII 379
Cdd:TIGR00890 320 VSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHAlteIGFEYTFIVTGAFALTSLAL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-393 |
5.20e-61 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 202.03 E-value: 5.20e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 9 WLVVLGTVIVQMGLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGL 88
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 89 VLSSQASSLILLyILAGVVVGYADGTAYITSLSNLIKWFP-ERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFI 167
Cdd:COG2223 85 LLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 168 YWGLIVTAMIVLGACLIHQAADQGAVQETNTHEyTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLVGLSAAT 247
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR-DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 248 AANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGNITIFPAIVGD 327
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 328 FFGMKNHSKNYGIVYQGFGFGALAGSFIGALL----GGFKPTFMVIGVLCVVSFIIAILIRAPKQKKEQE 393
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldatGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-383 |
7.36e-34 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 129.70 E-value: 7.36e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 8 PWLVVLGTVIVQM-GLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGL 86
Cdd:cd17355 1 GWVVLAVTFLILIlSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 87 GLVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLI-KWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQA 165
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAaWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 166 FIYWGLIVTAMIVLGACLIH-----QAADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSG----LYLIGMVKDI 236
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRrrpadLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVvgliVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 237 gvqlvGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGG 316
Cdd:cd17355 241 -----GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446671570 317 NITIFPAIVGDFFGMKNHSKNYGIVYQ----GFGFGALAGSFIGALLGGFKPTFMVIGVLCVVSFIIAILI 383
Cdd:cd17355 316 TVPLTAALAARYFGARSYGTLFGLVFAphqlGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
9-382 |
9.47e-26 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 107.11 E-value: 9.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 9 WLVVLGTVIVQMGL-GTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLG 87
Cdd:cd17314 2 WFVLYVSFLLSAMStGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 88 LVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFI 167
Cdd:cd17314 82 YTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 168 YWGLIVTAMIVLGACLI--HQAADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLVGLSA 245
Cdd:cd17314 162 ILGILAAIVLSVVSLLGfkEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 246 ATAANAVAMVAIFNTLGRIILGPLSD-KIGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVA-FCFGGNITIFPA 323
Cdd:cd17314 242 SFVTKLMSIYGLFNAFGRLLWGIVADfFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLgFSYGGLFTVYPA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446671570 324 IVGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGAL----LGGFKPTFMVIGVLCVVSFIIAIL 382
Cdd:cd17314 322 TVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKfydrTPSYISAVYIYAVIVFLASAILLA 384
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
9-384 |
3.30e-24 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 102.63 E-value: 3.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 9 WLVVLGTVIVQM-GLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLG 87
Cdd:cd17352 2 WVVVFASFLVNFfTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 88 LVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFI 167
Cdd:cd17352 82 LLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 168 YWGLIVTAMIVLGACLIhqaadqgavqetntheytmkeMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLvGLSAAT 247
Cdd:cd17352 162 ILGGLCLNLCVCGLLLR---------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 248 AANAVAMVAIFNTLGRIILGPLSDK--IGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVAsVAFCFGGNITIFPAIV 325
Cdd:cd17352 220 AAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVL-FGFCSGSYSSLTPVIL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446671570 326 GDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALL----GGFKPTFMVIGVLCVVSFIIAILIR 384
Cdd:cd17352 299 ADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLrdytGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-387 |
2.88e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 97.64 E-value: 2.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 2 KKSKVNPWLVVLGTVIVQMGLGT-IYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIA 80
Cdd:COG2807 10 RSRRAGRWLLLLAIVLVALNLRPaITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 81 GLALGLGLVLSSQASSLILLYILAgVVVGYADGTAYITsLSNLIK-WFPERKGLISGISVAAYGTGSLIFKYINAKLIDS 159
Cdd:COG2807 90 LLLLAAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVL-LPGLIKrWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 160 VGVSQAFIYWGLIVTAMIVLgacLIHQAADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQ 239
Cdd:COG2807 168 LGWRGALAVWALLALLALLL---WLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 240 LvGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLK-IVTGTFVVMASSVLVLSFVDLNYGIYFVCVASvaFCFGGNI 318
Cdd:COG2807 245 A-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLG--LGQGGLF 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446671570 319 TIFPAIVGDFFGMKNH-SKNYGIVYQGFGFGALAGSFIGALL----GGFKPTFMVIGVLCVVSFIIAILIRAPK 387
Cdd:COG2807 322 PLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALhdatGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-389 |
2.27e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.55 E-value: 2.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 1 MKKSKVNPWLVVLGTVIVQMGLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIA 80
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 81 GLALGLGLVLSSQASSLILLYILAgVVVGYADGTAYITSLSNLIKWFPERK-GLISGISVAAYGTGSLIFKYINAKLIDS 159
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 160 VGVSQAFIYWGLIVTAMIVLgaclihqaadqgavqetntheytmkemlgtkQVYLLFIMLFTSCMSGLYLIGMVKDIGVQ 239
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVE 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 240 LVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRL-KIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGNI 318
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446671570 319 TIFPAIVGDFFGMKNHSKNYGIVYQ-GFGFGALAGSFIGALL--GGFKPTFMVIGVLCVVSFIIAILIRAPKQK 389
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTfGFLGGALGPLLVGYLLdaTGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
8-375 |
4.02e-17 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 82.30 E-value: 4.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 8 PWLVVLGTVIVQMGLGTIYTWSLFNQPLVSKYGWSLNAVAItFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLA---- 83
Cdd:cd17354 2 RWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNL-LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILffpg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 84 -LGLGLVLSSQASSLIL-LYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYI-NAKLIDSV 160
Cdd:cd17354 81 yGVLWLVVTGLISDLSFwLMCLCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGSQLyKALFFHDS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 161 GVSQAFIYWGLIVTAMIVLGACLIHQAADQgavqetntheytmkEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQL 240
Cdd:cd17354 161 ARVFLFLAVLPAVVGLLAWFSVRIVSIEEG--------------EFLKDIDFWLLFISLFLGVGPGEMFINNLGQIGQSL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 241 VGLSAATAANAVAMvaIFNTLGRIILGPLSDKIGRLKIVTGT-FVVMASSVLVLSFV----DLNYGIYFVCVASVAFCFG 315
Cdd:cd17354 227 TGPSNTSTLVSLFS--IFSFLGRLLSGLLSDLFVRKFRLPRPsRMVLLLLILSLGHLlqafGLPSGALYVASALIGFGYG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446671570 316 GNITIFPAIVGDFFGMKNHSKNYGIVYQG-----FGFGALAGSFIGALLGG--------------FKPTFMVIGVLCVV 375
Cdd:cd17354 305 GLFSIAPTIVSELFGLKNFGTNYGFLMLApaigsLIFSVIYAGVYYDNGGEgagsddlscigphcFSLTFLIMAAVCLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-349 |
5.17e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.56 E-value: 5.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 1 MKKSKVNPWLVVLGTVIVQMGLGT-IYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMI 79
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLgIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 80 AGLALGLGLVLSSQASSLILLyILAGVVVGYADGTAYITSLSNLIKWFP-ERKGLISGISVAAYGTGSLIFKYINAKLID 158
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLL-LAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 159 SVGVSQAFIYWGLIVTAMIVLGACLIHQAADQGAVQETNTheytMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGV 238
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS----LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 239 QLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVASVAFCFGGNI 318
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLF 314
|
330 340 350
....*....|....*....|....*....|.
gi 446671570 319 TIFPAIVGDFFGMKNHSKNYGIVYQGFGFGA 349
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-353 |
2.69e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 73.22 E-value: 2.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 20 MGLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGLVLSSQASSLIL 99
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 100 LYILaGVVVGYADGTAYITSLSNLIKWFP-ERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWGLIVTAMIV 178
Cdd:pfam07690 88 LLVL-RVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 179 LGACLI--HQAADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLvGLSAATAANAVAMVA 256
Cdd:pfam07690 167 LLLLPRppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 257 IFNTLGRIILGPLSDKIG--RLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNH 334
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGrrRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
330
....*....|....*....
gi 446671570 335 SKNYGIVYQGFGFGALAGS 353
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-390 |
1.58e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 1.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 1 MKKSKVNPWLVVLGTVIVQMGLGTIyTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIA 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATA-LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 81 GLALGLGLVLSSQASSLILLyILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDS- 159
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLL-LLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 160 VGVSQAFIYWGL-IVTAMIVLGACLIHQAADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGV 238
Cdd:COG0738 159 LSLSWHLPYLILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 239 QLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVASVAFCFGGni 318
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP-GPWLALIGLALVGLGLSL-- 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446671570 319 tIFPAI---VGDFFGmKNHSKNYGIVYQGFGFGALAGSFIGALLG---GFKPTFMVIGVLCVVSFIIAILIRAPKQKK 390
Cdd:COG0738 316 -MFPTIfslALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLAdafGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-384 |
5.38e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.75 E-value: 5.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 11 VVLGTVIVQMGLGTIYtwslfnqPLVSKYGWSLNA----VAITFSITSLSLAFSTLFASKLQEKWGLRKLI---MIAGLA 83
Cdd:cd17325 1 LSLALFLDMLGYGIII-------PILPLYAESLGAsvaqIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLllgLLLLAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 84 LGLGLVLSSQASSLILLYILAGVVVGYAD--GTAYITSLSNlikwfPERKGLISGISVAAYGTGSLIFKYINAKLIDSVG 161
Cdd:cd17325 74 STLLFAFATSYWQLLLARFLQGLASAAVWpaAMALIADIAP-----PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 162 VSQAFIYWGLIVTAMIVLGACLIH----QAADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVkdIG 237
Cdd:cd17325 149 YRAPFLVCAALALLALVLALLLLPeprpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL--YA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 238 VQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlnyGIYFVCVASVAFCFGGN 317
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT---SFWLLLLLLALLGLGLG 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446671570 318 ITIFP--AIVGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALL---GGFKPTFMVIGVLCVVSFIIAILIR 384
Cdd:cd17325 304 LVFPAtlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLydaFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
212-382 |
1.63e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.83 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 212 VYLLFIMLFTSCMSGLYLIGMVKDIGVQLvGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVL 291
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 292 VLSFVDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALLG---GFKPTFMV 368
Cdd:COG2814 91 LCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdlfGWRWVFLV 169
|
170
....*....|....
gi 446671570 369 IGVLCVVSFIIAIL 382
Cdd:COG2814 170 NAVLALLALLLLLR 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-395 |
1.93e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 215 LFIMLFTSCMSGLYLIGMVKDIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLS 294
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 295 FVDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALL---GGFKPTFMVIGV 371
Cdd:pfam07690 81 FAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLaslFGWRAAFLILAI 159
|
170 180
....*....|....*....|....
gi 446671570 372 LCVVSFIIAILIRAPKQKKEQEEA 395
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPA 183
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-381 |
5.95e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 57.44 E-value: 5.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 39 YGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGLVLSSQASSLILLyILAGVVVGYADGTAYIT 118
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLL-LLGRFLLGLGSGLIDPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 119 SLSNLIKWFPER-KGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWGLIVTAMIVLGACLIHQAADQGAVQETN 197
Cdd:cd06174 105 VLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKN 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 198 THEYT------MKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSD 271
Cdd:cd06174 185 EEASSksvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 272 K-IGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKN---HSKNYGIVYQGFGF 347
Cdd:cd06174 265 RlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRgtaFGLLNTFGFLGGAI 344
|
330 340 350
....*....|....*....|....*....|....
gi 446671570 348 GALAGSFIGALLGGFKPTFMVIGVLCVVSFIIAI 381
Cdd:cd06174 345 GPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-383 |
1.11e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 53.34 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 40 GWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGLVLSSQASSLILLYILAGVVvGYADGTAYITS 119
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL-GVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 120 LSNLIKWFPER-KGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWGLIVTAMIVLGACLIhqaadqgavqetnt 198
Cdd:cd17319 113 IKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL-------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 199 heytmkemlgtKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKI---GR 275
Cdd:cd17319 179 -----------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgAR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 276 LKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFgmknHSKNYGIVYQGFGFGALAGSFI 355
Cdd:cd17319 248 RLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLL----PGEAAATAGGLINSGGNLGGFV 322
|
330 340 350
....*....|....*....|....*....|....*.
gi 446671570 356 GALL--------GGFKPTFMVIGVLCVVSFIIAILI 383
Cdd:cd17319 323 APLLigylvdatGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
9-382 |
7.88e-07 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 50.60 E-value: 7.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 9 WLVVLGTVIV-------QMGLGTIYTWSL--FNQplvskygwslnAVAITFSITSLSLAFSTL---FASKLQEKWGLRKL 76
Cdd:cd17429 2 WMVVLSSFIVhilvmgsQMALGILNMEWLeeFQQ-----------SRGLTAWISSLSMGITLIvgpFIGLFINTCGCRKT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 77 IMIAGLALGLGLVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKL 156
Cdd:cd17429 71 AIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 157 IDSVGVSQAFIYWGLIVTAMIVLGACLihqaadqgavqetntheytmkeMLGTKQVYLLFIM--LFTSCMSGLYLIGMVK 234
Cdd:cd17429 151 CAEFGWRNAMFIQGAVSLNLCVCGALM----------------------RLFTNKVFVAFIFwaLFAYCSFVIPFIHLPE 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 235 DigVQLVGLSAATAAN-AVAMVAIFNTLGRIILGPLSDK--IGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCvASVA 311
Cdd:cd17429 209 I--VKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLpcISVWNVFILANFTLGVCILILPLMHTYTGLAIVC-ALIG 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446671570 312 FcFGGNITIFPAIVGDFFGMKNHSKNYGIVYQGFGFGALAG----SFIGALLGGFKPTFMVIGVLCVVSFIIAIL 382
Cdd:cd17429 286 F-SSGYFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGppfaGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
39-383 |
9.59e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.40 E-value: 9.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 39 YGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGLVLSSQASSLILLYILaGVVVGYADGTAYIT 118
Cdd:cd17333 26 FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVL-MFLAGLGAGILDTG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 119 SLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWGLIVTAMIVLGACLIHQAADQGA---VQE 195
Cdd:cd17333 105 ANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSArnpQQS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 196 TNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGR 275
Cdd:cd17333 185 VGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKP 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 276 LKIVtgtfVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGM--KNHSKNYGIVYQGFGFGALAGS 353
Cdd:cd17333 265 HTLL----VLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNlpYAKGKGTSVLLAAGSIGGAIIP 340
|
330 340 350
....*....|....*....|....*....|..
gi 446671570 354 FIGALLGGF--KPTFMVIGVLCVVSFIIAILI 383
Cdd:cd17333 341 FIMGFIAEAvgIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
212-382 |
2.49e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 212 VYLLFIMLFTSCMSGLYLIGmvkdIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVL 291
Cdd:cd17370 204 LYLLAVALFALGNFSFAFLI----LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 292 VLSFVDLNYGIYFVCVASVAFcFGGNITIFPAIVGDFFGMKNHSKNYGIVYQGFGFGALAGSFI-GALLGGFKPTF-MVI 369
Cdd:cd17370 280 GFALGSSLWLLLLGFILWGLY-MGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIaGYLWDLISPSAaFLF 358
|
170
....*....|...
gi 446671570 370 GVLCVVSFIIAIL 382
Cdd:cd17370 359 SAVLALIALLLLL 371
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
9-360 |
6.09e-06 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 47.77 E-value: 6.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 9 WLVVL-GTVIVQMGLGTIYTWSLFNQPLVSKYGWSLNAVAItfsITSLSLA---FSTLFASKLQEKWGLRKLIMIAGLAL 84
Cdd:cd17423 2 WVVVLaAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSW---ITSIGLAvqqLASPVGSALSTRYGARPVVMLGGLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 85 GLGLVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQ 164
Cdd:cd17423 79 SLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 165 AFIYWGLIVTAMIVLGACLIHQAADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLVGLS 244
Cdd:cd17423 159 ALLLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 245 AATAANAVAMVAIFNTLGRIILGPLSD-KIGRLKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGNITIFPA 323
Cdd:cd17423 239 EYQAAFVVSVAAVADAVGRLFSGWLADlGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFS 318
|
330 340 350
....*....|....*....|....*....|....*..
gi 446671570 324 IVGDFFGMKNhsknygiVYQGFGFGALAGSfIGALLG 360
Cdd:cd17423 319 VLPELVGVER-------VLNATGLLQMIES-VGGLLG 347
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
9-315 |
9.80e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.23 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 9 WLVVLGTVIVQMGlgtIYTWSLFnqpLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGL 88
Cdd:cd17475 2 TLAQAAASLVAQG---IPALAPF---LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 89 VLSSQASSLILLyILAGVVVGYADGTAYITSLSNLIKWFPER-KGLISGISVAA----YGTGSLIFKYINAKLidsvGVS 163
Cdd:cd17475 76 LLMALVGSYPVL-LVLLFLVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGvplgGALAAALLPPLALHY----GWR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 164 QAFIYWGLIVTAMIVLGACLIHQAADQGAVQETNTHEYT-MKEMLGTKQVYLLFIMLFTSCMSGL----YLIGMVKDIgv 238
Cdd:cd17475 151 AAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRsLKEVLRNRDVWLIAIAGALLVAPQFalltFLLLFLHDH-- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 239 qlVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGR------LKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAF 312
Cdd:cd17475 229 --LGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrpvLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLF 306
|
...
gi 446671570 313 CFG 315
Cdd:cd17475 307 AIG 309
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
265-400 |
1.51e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 46.86 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 265 ILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVAsVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQG 344
Cdd:cd17388 57 ILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP-TLWWLYLGRI-IAGITGATGAVAAAYIADVTPPEQRARNFGLLGAA 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446671570 345 FGFGALAGSFIGALLGGFKPT--FMVIGVLCVVSFIIAILIRAPKQKKEQEEAYRSVA 400
Cdd:cd17388 135 FGLGFIAGPALGGLLGEISPRapFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRR 192
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
42-381 |
1.91e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 42 SLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGLVLSSQASSLILLYI---LAGVVVG--YADGTAY 116
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVlrfLQGIGIGgeYPGASTY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 117 ITSLsnlikWFPERKGLISGISVAAYGTGSLIfkyinAKLIDSVGVSQAFIYWG----LIVTAMIVLGACLIHQaadqga 192
Cdd:cd17316 114 VAEF-----APSKRRGFALGLLQSGWALGALL-----AALVASLLIPLLSGDWGwrilFLIGALPALLALLLRR------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 193 vqetntheytmkemlgtkqvYLLFIMLFTSCMSGLY--LIGMVKDIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLS 270
Cdd:cd17316 178 --------------------RTLLLILLWFFISFGYygLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 271 DKIGRLKIVTGTFVVMA-SSVLVLSFVDLNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQ----GF 345
Cdd:cd17316 238 DRIGRKKTLVIGLILSGiLALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNlgrlGG 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 446671570 346 GFGALAGSFIGALLGGFKPTFMVIGVLCVVSFIIAI 381
Cdd:cd17316 318 GGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
216-394 |
1.19e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.95 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 216 FIMLFTSCMSGLYLIGMVKDIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSF 295
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 296 VDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALL-----GGFKPTFMVIG 370
Cdd:cd06174 81 AP-SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasslgFGWRAVFLIAA 159
|
170 180
....*....|....*....|....
gi 446671570 371 VLCVVSFIIAILIRAPKQKKEQEE 394
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAK 183
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
128-362 |
1.45e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 128 PERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWGL-IVTAMIVLGACLIHQAADQGAVQETNTHEY---TM 203
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTaLIFAVLGLLAFLLTFFGTKERPVPEEEKVSlkeSL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 204 KEMLGTKQ-VYLLFIMLFTSCMSGLYLIGMVKdIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGT 282
Cdd:COG2211 222 KALLKNRPfLLLLLAYLLFFLALALVAALLLY-YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 283 FVVMASSVLVLSFVDL-NYGIYFVCVASVAFCFGGNITIFPAIVGD---FFGMKNHSKNYGIVYQGFGFGALAGSFIGAL 358
Cdd:COG2211 301 LLLAALGLLLLFFLGPgNLWLLLVLAALAGIGLGAILVLPWAMLADvvdYDEWKTGRRREGLYFGIFTFAIKLGQALAGA 380
|
....
gi 446671570 359 LGGF 362
Cdd:COG2211 381 LAGL 384
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
56-180 |
1.59e-04 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 43.67 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 56 SLAFSTLF-----ASKLQEKWGLRKLIMIAGLALGLGLVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPER 130
Cdd:cd17420 50 ALAMGMIFfcspiVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRR 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446671570 131 KGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWGLIVTAMIVLG 180
Cdd:cd17420 130 LGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCS 179
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
41-386 |
1.60e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 43.34 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 41 WSLNAVAIT--FSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGLVLSSQASS---LILLYILAGVVVGYADGTA 115
Cdd:cd17365 29 WGLSPAQLGpvGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSvlqLALLRFLTGLGLGAAMPNA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 116 yITSLSNLIKwfPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWGLIVTAMIVLgaclihqaadqgavqe 195
Cdd:cd17365 109 -ITLVSEYAP--ARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL---------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 196 tntheytmkeMLGTKQVYLLFIMlftsCMSGLYLIGMVKDIGVQLVGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGR 275
Cdd:cd17365 170 ----------LRGTLLLWVTFFM----GLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 276 LKIVTGTFVVMASSVLVLSFVDLNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVyQGFG-FGALAGSF 354
Cdd:cd17365 236 KRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWA-LGVGrLGAILGPL 314
|
330 340 350
....*....|....*....|....*....|....*.
gi 446671570 355 IGALL----GGFKPTFMVIGVLCVVSFIIAILIRAP 386
Cdd:cd17365 315 LGGLLlaagLGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
212-383 |
1.96e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 212 VYLLFIMLFTSCMSGLYLIGMVKDIGVQLvGLSAATAANAVAMVAIFNTLGRIILGPLSDKIGRLKIVTGTFVVMASSVL 291
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 292 VLSFVDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQGFGFGALAGSFIGALLG---GFKPTFMV 368
Cdd:cd17324 80 LAALAP-SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqllGWRAAFLA 158
|
170
....*....|....*
gi 446671570 369 IGVLCVVSFIIAILI 383
Cdd:cd17324 159 IAVLALLAALLLWRL 173
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
9-183 |
2.38e-04 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 42.81 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 9 WLVVLGTVIVQ-MGLGTIYTWSLFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLG 87
Cdd:cd17422 2 WAVAVAFFFVEvFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 88 LVLSSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFI 167
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170
....*....|....*.
gi 446671570 168 YWGLIVTAMIVLGACL 183
Cdd:cd17422 162 VVGALQLNIVVCGALL 177
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
261-399 |
2.39e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 261 LGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlnyGIYFVCVASVAFCFGGNItIFP---AIVGDFFGMKNHSKN 337
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH---SPWLFAIALVLTGFGGGL-FEPaseAMIADVTTPENRTRA 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446671570 338 YGIVYQGFGFGALAGSFIGALLG--GFKPTFMVIGVLCVVSFIIAIL-------IRAPKQKKEQEEAYRSV 399
Cdd:cd17329 126 FSLLYWAINLGVAIGPLLGGLLLlySFRLLFLAAAVLFLLAALVLLFllpetrpKRRAAEKTEILRGYKIV 196
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
264-395 |
4.37e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.22 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 264 IILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQ 343
Cdd:cd17328 52 PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP-NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYF 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446671570 344 GF----GFGALAGSFIGALLGGFKPTFMVIGVLCVVSFIIAILIRAPKQKKEQEEA 395
Cdd:cd17328 131 AIplgsGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGG 186
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
91-352 |
7.32e-04 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 41.34 E-value: 7.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 91 SSQASSLILLYILAGVVVGYADGTAYITSLSNLIKWFPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGVSQAFIYWG 170
Cdd:cd17428 85 SAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLLIVG 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 171 LIVTAMIVLGACLihqaadqgavqetntheytmkEMLGTKQVYLLFIMLFTSCMSGLYLIGMVKDIGVQLVGLSAATAAN 250
Cdd:cd17428 165 ALALNLLACGSLM---------------------RLFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 251 AVAMVAIFNTLGRIILGPLSDK--IGRLKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVASVAFcFGGNITIFPAIVGDF 328
Cdd:cd17428 224 LVSIIGITTAIGKLILGVLADFkwVNSLYLYVLTLIGMGAALLAIPFAK-SYLTLAVLSAILGF-LSGNWSIFPYVTTKT 301
|
250 260
....*....|....*....|....
gi 446671570 329 FGMKNHSKNYGIVYQGFGFGALAG 352
Cdd:cd17428 302 VGIEKLGHAYGILMFFAGLGNSLG 325
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
261-375 |
7.36e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 7.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 261 LGRIILGPLSDKIGRLKIVTGTFVV----MASSVLVLSFVDLnygIYFVCVASVAfcFGGNITIFPAIVGDFFGMKNHSK 336
Cdd:TIGR00895 67 FGALFFGPLADRIGRRRVLLWSILLfsvfTLLCALATNVTQL---LILRFLAGLG--LGGLMPNLNALVSEYAPKRFRGT 141
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 446671570 337 NYGIVYQGFGFGALAGSFIGALLG---GFKPTFMVIGVLCVV 375
Cdd:TIGR00895 142 AVGLMFCGYPIGAAVGGFLAGWLIpvfGWRSLFYVGGIAPLL 183
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
265-383 |
1.05e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 265 ILGPLSDKIGRLKIVTGTfvvMASSVLVLSFVDLNYGIYFVCVA-SVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIVYQ 343
Cdd:cd17330 53 LWGRLSDRYGRKPVLLLS---LAGSAVSYVLLGLSRNLWLLFLArFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISA 129
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446671570 344 GFGFGALAGSFIGALLGGFKP---TFMVIGVLCVVSFIIAILI 383
Cdd:cd17330 130 AFGLGFILGPALGGFLSTPYGyalPFLVAAALALLNLVLVLFF 172
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
35-381 |
1.08e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 35 LVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGLGLVLSSQASS---LILLYILAGVVVG-- 109
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNywlLLLLVALAGIGSAaf 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 110 YADGTAYITSLSnlikwfPERKGLISGISVAAYGTGSLIFKYINAKLIDSVGvSQAFIYWGLIVTAMIVLGACLIHQAAD 189
Cdd:cd17478 102 HPEGARLASQAA------GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-GLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 190 QGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTSCMsglYLIGMVKDIGVQLV--GLSAATAANAVAMVAIFNTLGRIILG 267
Cdd:cd17478 175 PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSW---VLSSLTTFLPFYLVqrGYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 268 PLSDKIGRLKIVTGTFVVMASSVLVLSFVD--LNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNhsknyGIVYQ-G 344
Cdd:cd17478 252 PLSDRFGRRRVIIASLLLAAPFLLLFLLTPgiWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLAS-----GLMMGlS 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 446671570 345 FGFGALAGSFIGAL--LGGFKPTFMVIGVLCVVSFIIAI 381
Cdd:cd17478 327 FGLGGIGAPVLGALadAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
262-383 |
1.34e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.75 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 262 GRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGIV 341
Cdd:cd17371 50 GGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ-NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYV 128
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 446671570 342 YQGFGFGALAGSFIGALLGGFKPTFMVIGVLCVVSFIIAILI 383
Cdd:cd17371 129 QSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLV 170
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-384 |
2.06e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 46 VAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAglalglglvlssqasslILLYILAGVVVGYAD------------- 112
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAG-----------------LLLYGIGGVAGLFLDslyallasrallg 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 113 -GTAYITSLSNLI--KWF--PERKGLIsGISVAAYGTGSLIFKYINAkLIDSVGVSQAFIYWGLivtAMIVLGACLIHQA 187
Cdd:cd17473 100 iGVAGIMTLATALigDYFegEERAKML-GLQSAAMSLGGVVFLLLGG-ALAEIGWRAPFLVYLL---ALPVLILVLLFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 188 ADQGAVQETNTHEYTMKEMLGTKQVYLLFIMLFTScMSGLYLIGMVKDIGVQLVGL-SAATAANAVAMVAIFNTLGRIIL 266
Cdd:cd17473 175 EPARKSKSAASPGAATAAALPWKRVLPIYFLAFLA-MLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 267 GPLSDKIGRLKIVTGTFVVMASSVLVLSFVdlnYGIYFVCVASVAFCFGGNItIFPAI---VGDFFGMKNHSKNYGIVYQ 343
Cdd:cd17473 254 GRLKRRLGKRRLLAIGFALMALGFLLLALA---SGLWVVLLGAILAGLGFGL-LLPTLnswAMSLVPPELRGRAMGIVTS 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446671570 344 GFGFGA----LAGSFIGALLGGFKPTFMVIGVLCVVSFIIAILIR 384
Cdd:cd17473 330 AFFLGQflspLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
261-383 |
7.83e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 37.87 E-value: 7.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 261 LGRIILGPLSDKIGRLKIVTGTFVVMASSVLVLSFVDlNYGIYFVCVASVAFCFGGNITIFPAIVGDFFGMKNHSKNYGI 340
Cdd:COG0477 64 IGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP-SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGL 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446671570 341 VYQGFGFGALAGSFIGALL---GGFKPTFMVIGVLCVVSFIIAILI 383
Cdd:COG0477 143 WGAAIGLGLALGPLLGGLLvaaLGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
8-179 |
8.23e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 37.95 E-value: 8.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 8 PWLVVLGTV-IVQMGLGTIYTwslFNQPLVSKYGWSLNAVAITFSITSLSLAFSTLFASKLQEKWGLRKLIMIAGLALGL 86
Cdd:cd17335 199 RVLAFLLVAfLMGFGHGLIYS---FLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVV 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446671570 87 GLVLSSQASSLILLYILAgVVVGYADGTAYITSLSNLIKWFPER-----KGLISGISvaaYGTGSLIFKYINAKLIDSVG 161
Cdd:cd17335 276 RWLLYSFLENPWLVLPIE-LLHGLTFALVWAAAVSYASAAAPPGlrataQGLLQGLY---FGLGGGLGSLIGGYLYEAFG 351
|
170
....*....|....*...
gi 446671570 162 VSQAFIYWGLIVTAMIVL 179
Cdd:cd17335 352 ARTTFRFFAIAALAGLLA 369
|
|
| |
