AbrB C-terminal domain; This is the C-terminal domain of AbrB protein from Bacillus subtilis. AbrB is a transition state regulator. Functions of AbrB include biofilm formation, antibiotic production, competence development, extracellular enzyme production, motility, and sporulation. The C-terminal domain is responsible for multimerization and, to a lesser extent than the N-terminal domain, also contributes in DNA binding.

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                 ....*....|....*....|....*....|....*.
gi 446673403  52 CFVTGEVSENNIELLGGRMFLSKEGAIELLDLIQKS 87
Cdd:pfam18277  2 CMITGEISEENKSLANGKIVLSPEGAEILLKEIQEY 37

SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446673403    8 RKVDELGRVVIPVELRRTLGITEGTALDFHVDGENIVLRRHEKS 51
Cdd:smart00966  1 VKVGNSGQVTIPKEVREKLGIKEGDEVELEVDGDGIILEPVKKA 44

Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are also found on chromosomes and to be associated with a number of biological functions such as: reduction of protein synthesis, gene regulation and retardation of cell growth under nutritional stress. This family includes proteins from a number of different pairings, eg MazE, AbrB, VapB, PhoU, PemI-like and SpoVT. MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation, and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446673403   8 RKVDELGRVVIPVELRRTLGITEGTALDFHVDGENIVLR 46
Cdd:pfam04014  1 FKVGNSGAVRIPKEVRKALGIKEGDEVELEVDGDKIILK 39

N-terminal subdomain of transcriptional regulator MraZ; This family contains the N-terminal domain of proteins of unknown function (UPF0040), implicated in a cellular function of bacterial cell division. It includes protein MraZ which is present in almost all bacteria and appears to be essential for survival. It is found in gene clusters associated with the cellular function of cell division and cell wall biosynthesis, including mraW, ftsI, murE, murF, ftsW and murG. Members of this family contain two tandem copies of the domain; the crystal structure of a member of this family (MPN314) reveals that the two subdomains are related by a pseudo two-fold axis, with each subdomain containing a highly conserved DXXXR sequence motif in close proximity to each other, suggested to form the functional site.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 446673403  8 RKVDELGRVVIPVELRRTLGitegtaldfhVDGENIVLRRHEKSC 52
Cdd:cd16320   6 HKLDAKGRLSIPAKFREELG----------AGGEGLVLTRGLDGC 40

SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446673403    8 RKVDELGRVVIPVELRRTLGITEGTALDFHVDGENIVLRRHEKS 51
Cdd:smart00966  1 VKVGNSGQVTIPKEVREKLGIKEGDEVELEVDGDGIILEPVKKA 44

Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are also found on chromosomes and to be associated with a number of biological functions such as: reduction of protein synthesis, gene regulation and retardation of cell growth under nutritional stress. This family includes proteins from a number of different pairings, eg MazE, AbrB, VapB, PhoU, PemI-like and SpoVT. MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation, and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446673403   8 RKVDELGRVVIPVELRRTLGITEGTALDFHVDGENIVLR 46
Cdd:pfam04014  1 FKVGNSGAVRIPKEVRKALGIKEGDEVELEVDGDKIILK 39

Antitoxin component MazE of the MazEF toxin-antitoxin module [Defense mechanisms];

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                ....*....|....*....|....*....|....*
gi 446673403 16 VVIPVELRRTLGITEGTALDFHVDGENIVLRRHEK 50
Cdd:COG2336  14 VRIPKALLEQLGLKEGDEVELEVEDGRIVIRPVRR 48