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Conserved domains on  [gi|446679613|ref|WP_000756959|]
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MULTISPECIES: type 3 fimbria major subunit MrkA [Enterobacteriaceae]

Protein Classification

fimbrial protein( domain architecture ID 10007530)

fimbrial protein similar to Escherichia coli fimbrial adapter PapF, which is required for the correct presentation of the PapG adhesin at the distal end of the tip fibrillum

Gene Ontology:  GO:0009289|GO:0007155

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
FimA COG3539
Pilin (type 1 fimbrial protein) [Cell motility];
1-202 1.43e-18

Pilin (type 1 fimbrial protein) [Cell motility];


:

Pssm-ID: 442760 [Multi-domain]  Cd Length: 172  Bit Score: 78.93  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMATAFFgmtaahAADTNVGGGQVNFFGKVTDVSCTVSVNGQgsDANVYLSPVTLTEVKAAAADTylKPKSF 80
Cdd:COG3539    1 MKKLLLALLLALALS------AAAAAAADGTVNFTGTVVAPTCTINTGSK--DQTVDLGTVSTSDLNGVGSTS--GPKPF 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  81 TIDVSNCQAADGTkqddvsKLGVNWTGgnllaGATSKQQGYLANTEASGAQNIQLVLSTDNATALTnkiiPGDSTQPKAK 160
Cdd:COG3539   71 SIKLTNCDAGTSN------SVKVTFTG-----TADSANPGLLANTGSGGASGVGIQLLDSDGTPIP----LGTPSSAVTL 135
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446679613 161 GDASAvadgARFTYYVGYATSApTTVTTGVVNSYATYEITYQ 202
Cdd:COG3539  136 TSNGS----ATLPFYARYVATG-ATVTAGSFNATATFTIDYQ 172
 
Name Accession Description Interval E-value
FimA COG3539
Pilin (type 1 fimbrial protein) [Cell motility];
1-202 1.43e-18

Pilin (type 1 fimbrial protein) [Cell motility];


Pssm-ID: 442760 [Multi-domain]  Cd Length: 172  Bit Score: 78.93  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMATAFFgmtaahAADTNVGGGQVNFFGKVTDVSCTVSVNGQgsDANVYLSPVTLTEVKAAAADTylKPKSF 80
Cdd:COG3539    1 MKKLLLALLLALALS------AAAAAAADGTVNFTGTVVAPTCTINTGSK--DQTVDLGTVSTSDLNGVGSTS--GPKPF 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  81 TIDVSNCQAADGTkqddvsKLGVNWTGgnllaGATSKQQGYLANTEASGAQNIQLVLSTDNATALTnkiiPGDSTQPKAK 160
Cdd:COG3539   71 SIKLTNCDAGTSN------SVKVTFTG-----TADSANPGLLANTGSGGASGVGIQLLDSDGTPIP----LGTPSSAVTL 135
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446679613 161 GDASAvadgARFTYYVGYATSApTTVTTGVVNSYATYEITYQ 202
Cdd:COG3539  136 TSNGS----ATLPFYARYVATG-ATVTAGSFNATATFTIDYQ 172
PRK15239 PRK15239
putative fimbrial protein StaA; Provisional
1-202 4.32e-07

putative fimbrial protein StaA; Provisional


Pssm-ID: 185152  Cd Length: 197  Bit Score: 48.19  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMATAFfGMTAAHAadtnVGGGQVNFFGKVTDVSC----TVSVNGQGSDANVYLSPVTLT----EVKAAAAD 72
Cdd:PRK15239   1 MKKVLLATAVFMAL-GSSSVMA----VEGGRINFEGLVSAETCkkvvSSAVGNSNIDGTVTLKTAHVSdvtaEVQNSTAG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  73 TYLKPKSFTIDVSNCqAADGTKQDDVSKLGVNWTGGNLLAGATSKQQGylanteASGAQNIQL-VLSTDNATALTNKIIp 151
Cdd:PRK15239  76 VNAEDFSIIIDCSDA-GAGLVKSHLTMSSSFSNTKGTLDNDETLTRSG------IEAAKAVDIaVHHVDDANALSLVKI- 147
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446679613 152 gdsTQPKAKGDASAVADGARFTYYVGYATS--APTTVTTGVVNSYATYEITYQ 202
Cdd:PRK15239 148 ---NDPSNTMEESFTNGIATYNFKASYVKSsdAGASVTTGLVSTNAIYTFTYE 197
Fimbrial pfam00419
Fimbrial protein;
32-202 3.47e-04

Fimbrial protein;


Pssm-ID: 425671  Cd Length: 152  Bit Score: 39.34  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   32 VNFFGKVTDV--SCTVSvngQGSDANVYLSPVTLTEVKAAAADTylKPKSFTIDVsNCQAADGtkqddvsklGVNWTGGN 109
Cdd:pfam00419   1 INFTGTVTRVpaTCKIT---AGTPIEVDFGQIPVNELNAGGEGS--RQKPFSITL-ECSSGSS---------AVKVTVGL 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  110 LLAGATSKQQGYLANTEASGAQNIQLVLSTDNataltNKIIPGDSTQPKAKGDASAVADGArFTYYVGYATSAPTTVTTG 189
Cdd:pfam00419  66 FGTADASSPNLLLTGNGAGAATGVGIRLYDAN-----GGALPPNNGTSSIPVSATAAVATG-ITFTASLVATTGGTPTAG 139
                         170
                  ....*....|...
gi 446679613  190 VVNSYATYEITYQ 202
Cdd:pfam00419 140 DFNATATIVVDYQ 152
 
Name Accession Description Interval E-value
FimA COG3539
Pilin (type 1 fimbrial protein) [Cell motility];
1-202 1.43e-18

Pilin (type 1 fimbrial protein) [Cell motility];


Pssm-ID: 442760 [Multi-domain]  Cd Length: 172  Bit Score: 78.93  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMATAFFgmtaahAADTNVGGGQVNFFGKVTDVSCTVSVNGQgsDANVYLSPVTLTEVKAAAADTylKPKSF 80
Cdd:COG3539    1 MKKLLLALLLALALS------AAAAAAADGTVNFTGTVVAPTCTINTGSK--DQTVDLGTVSTSDLNGVGSTS--GPKPF 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  81 TIDVSNCQAADGTkqddvsKLGVNWTGgnllaGATSKQQGYLANTEASGAQNIQLVLSTDNATALTnkiiPGDSTQPKAK 160
Cdd:COG3539   71 SIKLTNCDAGTSN------SVKVTFTG-----TADSANPGLLANTGSGGASGVGIQLLDSDGTPIP----LGTPSSAVTL 135
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446679613 161 GDASAvadgARFTYYVGYATSApTTVTTGVVNSYATYEITYQ 202
Cdd:COG3539  136 TSNGS----ATLPFYARYVATG-ATVTAGSFNATATFTIDYQ 172
PRK15239 PRK15239
putative fimbrial protein StaA; Provisional
1-202 4.32e-07

putative fimbrial protein StaA; Provisional


Pssm-ID: 185152  Cd Length: 197  Bit Score: 48.19  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMATAFfGMTAAHAadtnVGGGQVNFFGKVTDVSC----TVSVNGQGSDANVYLSPVTLT----EVKAAAAD 72
Cdd:PRK15239   1 MKKVLLATAVFMAL-GSSSVMA----VEGGRINFEGLVSAETCkkvvSSAVGNSNIDGTVTLKTAHVSdvtaEVQNSTAG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  73 TYLKPKSFTIDVSNCqAADGTKQDDVSKLGVNWTGGNLLAGATSKQQGylanteASGAQNIQL-VLSTDNATALTNKIIp 151
Cdd:PRK15239  76 VNAEDFSIIIDCSDA-GAGLVKSHLTMSSSFSNTKGTLDNDETLTRSG------IEAAKAVDIaVHHVDDANALSLVKI- 147
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446679613 152 gdsTQPKAKGDASAVADGARFTYYVGYATS--APTTVTTGVVNSYATYEITYQ 202
Cdd:PRK15239 148 ---NDPSNTMEESFTNGIATYNFKASYVKSsdAGASVTTGLVSTNAIYTFTYE 197
PRK15210 PRK15210
fimbrial protein;
3-201 4.96e-06

fimbrial protein;


Pssm-ID: 185132  Cd Length: 194  Bit Score: 45.46  E-value: 4.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   3 KVLLSAAMATAFFGmTAAHAADTN-----VGGGQVNFFGKVTDVSCTVSvngQGSDA-NVYLSPVTLTEVKAAAADTYLK 76
Cdd:PRK15210   4 KIILAMAAAGMMYG-ASVFAADTTptagpFGSGKILFTGTITNSPCDIA---PGDDAiTVPFGQISYRKLNTADATTESK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  77 PksFTIDVSNCqAADGTKQD------DVSKLGVNWTGgnllaGATSKQQGYLANTEASGAqNIQLvLSTDNATALTnkii 150
Cdd:PRK15210  80 P--FTIHLQNC-AFDPNIPDtagsagKMSKVTVSFSG-----TANTSKKAYTTSGSAQHV-GVQL-LKSDNTSIIE---- 145
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446679613 151 pgdSTQPKAKGDASAVADGARFTYYVGYATSAPTTVTTGVVNSYATYEITY 201
Cdd:PRK15210 146 ---PNTPMPDGDAQQLQAGNNELNFFARLIALDNGVTPGDFNASVTYTLKY 193
PRK15307 PRK15307
major fimbrial protein StkA; Provisional
1-202 6.44e-06

major fimbrial protein StkA; Provisional


Pssm-ID: 185207  Cd Length: 201  Bit Score: 45.03  E-value: 6.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMaTAFFGMTAAHAADTNVGggQVNFFGKVTDVSCTVSVNGQ----GSDANVYLSPVTLTEVKAAAA-DTYL 75
Cdd:PRK15307   3 LKKYGLAAAV-AMTLSASSAMAADPDTG--TITFHGLVTNNTCNISLDNKidqdGNDFDITLPTVFVKDFATALGvNSTL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  76 KPKSFTIDVSNCqaaDGTKQDDVSKLGVNWTGGNLLAGATSKQQGYLANTeasgAQNIQLVLSTDNATAlTNKIIPGdst 155
Cdd:PRK15307  80 GEKQFTLNLSEC---DNATLKDASAQFNSWGGSSATSGGLLVPPANLQGS----ATNVNLVLANNGNTA-TDLIKID--- 148
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446679613 156 QPKAKGDASAVADGA-----RFTYYVGYATSAPTT-VTTGVVNSYATYEITYQ 202
Cdd:PRK15307 149 QPNNTQKATISTDGTgdlfyRVAYTQGQKWNADTSpVTSGTVQAQVAFTMIYN 201
PRK15262 PRK15262
putative fimbrial protein StaF; Provisional
1-202 9.11e-05

putative fimbrial protein StaF; Provisional


Pssm-ID: 237933  Cd Length: 197  Bit Score: 41.60  E-value: 9.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMATAFFGmtAAHAADTNVgggqvNFFGKVTDVSCTVSVNGQGsdaNVYLSPVTLTEVKAAAADTYLKP--K 78
Cdd:PRK15262   6 MKKIILFLGLLFALTS--PPAYAGQDV-----DLTANIKNSTCQSGISNNG---NVDLGTVGVGYFADNVTAETYYPggK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  79 SFTIDVSNCQAADGTkqDDVSKLGVNWTGgnlLAG--ATSKQQGYLANTEASGAQNIQLVLSTDNATALTNKIIPGDSTQ 156
Cdd:PRK15262  76 EFTITVVDCALQGTG--SVLNQLHFDFRP---QSGvmATGSQQIFANEAVAGGAKNVGVVIFSIQDPANTFNVLNSDGSS 150
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446679613 157 PKAKGDASAVADGARFTYYVGYA-TSAPTTVTTGVVNSYATYEITYQ 202
Cdd:PRK15262 151 RSVYPVMTSALNNSSWKFYARMQkIDPALDVTSGQVTSHVLVDVYYE 197
PRK15296 PRK15296
fimbrial protein SthA;
17-202 2.78e-04

fimbrial protein SthA;


Pssm-ID: 185196  Cd Length: 181  Bit Score: 40.07  E-value: 2.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  17 MTAAHAADTNVGGGQVNFFGKVTDVSCTVSVNGQGsDANVYLSPVTLTEVKAAAADTylKPKSFTIDVSNCQAADGtkqd 96
Cdd:PRK15296  11 MLTAVASTPVFAQNTITFNGKIYDQACTVQVNGST-DTTIDLGNYSKERIAEKGATT--DYVPFTVSLVSCPEAGT---- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  97 dvsklGVNWTGGNLLAGAT-SKQQGYLANTEA---SGAQNIQLVLSTDNATALTNKIIPGDSTQPKAKGDASavadgarF 172
Cdd:PRK15296  84 -----GVPTQAMFRFHGATdDSNPTYFKNADEgseTGAAGVGISIQNASHSDVTDNTDDAAVNLPTDGSTAD-------F 151
                        170       180       190
                 ....*....|....*....|....*....|
gi 446679613 173 TYYVGYATSAPTTVTTGVVNSYATYEITYQ 202
Cdd:PRK15296 152 TYYAAMANDGSATVTGGDVSTQVTYTVSYQ 181
Fimbrial pfam00419
Fimbrial protein;
32-202 3.47e-04

Fimbrial protein;


Pssm-ID: 425671  Cd Length: 152  Bit Score: 39.34  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   32 VNFFGKVTDV--SCTVSvngQGSDANVYLSPVTLTEVKAAAADTylKPKSFTIDVsNCQAADGtkqddvsklGVNWTGGN 109
Cdd:pfam00419   1 INFTGTVTRVpaTCKIT---AGTPIEVDFGQIPVNELNAGGEGS--RQKPFSITL-ECSSGSS---------AVKVTVGL 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  110 LLAGATSKQQGYLANTEASGAQNIQLVLSTDNataltNKIIPGDSTQPKAKGDASAVADGArFTYYVGYATSAPTTVTTG 189
Cdd:pfam00419  66 FGTADASSPNLLLTGNGAGAATGVGIRLYDAN-----GGALPPNNGTSSIPVSATAAVATG-ITFTASLVATTGGTPTAG 139
                         170
                  ....*....|...
gi 446679613  190 VVNSYATYEITYQ 202
Cdd:pfam00419 140 DFNATATIVVDYQ 152
PRK15209 PRK15209
long polar fimbrial protein LpfA; Provisional
1-202 8.98e-04

long polar fimbrial protein LpfA; Provisional


Pssm-ID: 185131 [Multi-domain]  Cd Length: 174  Bit Score: 38.41  E-value: 8.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLsaAMATAFFGMTAAHAADTnvGGGQVNFFGKVTDVSCTVSVNGQGSDanVYLSPVTLTEVKAAAADTYLKPksF 80
Cdd:PRK15209   1 MKKVVF--ALSALALTSTSVFAAES--GDGTVKFTGEIVDAPCVVSTDSQNQE--VVLGQVKKSVFKAIGDKSSAKP--F 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613  81 TIDVSNCQAADGTKQdDVSKLGVnwtggnllaGATSKQQGYLANTEASGAQNIQLVLsTDNatalTNKIIPGDSTQpkak 160
Cdd:PRK15209  73 QIKLEDCDITTNKKV-NVSFNGV---------GDADDSTLVSVSTEAGAATGVGIGI-YDN----ANTLVELNTGK---- 133
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446679613 161 gDASAVADGARFTYYVGYATSAPTTVTTGVVNSYATYEITYQ 202
Cdd:PRK15209 134 -STTTLAAGQTVLYFTANYVSTKDTVTTGYGNAEVDFNLSYE 174
PRK15194 PRK15194
type 1 fimbrial protein subunit FimA;
1-87 7.12e-03

type 1 fimbrial protein subunit FimA;


Pssm-ID: 237920  Cd Length: 185  Bit Score: 36.09  E-value: 7.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446679613   1 MKKVLLSAAMATAFFGMTAAHAAD---TNVGGGQVNFFGKVTDVSCtvSVNGQGSDANVYLSPVTLTEVKAAAADTYLKP 77
Cdd:PRK15194   1 MKLRFISSAIASLLFVAGAAYAADptpVSVDGGTIHFEGELVNAAC--SVNTDSADQTVTLGQYRTAIFTAVGNTTALIP 78
                         90
                 ....*....|
gi 446679613  78 ksFTIDVSNC 87
Cdd:PRK15194  79 --FTIQLNDC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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