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MULTISPECIES: malate dehydrogenase (quinone) [Enterobacteriaceae]
Protein Classification
malate:quinone oxidoreductase ( domain architecture ID 10012287 )
malate:quinone oxidoreductase catalyzes the oxidation of malate to oxaloacetate using quinone as the electron acceptor as part of the citric acid cycle
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05257
PRK05257 malate:quinone oxidoreductase; Validated
27-520
0e+00
malate:quinone oxidoreductase; Validated
Pssm-ID: 179979
Cd Length: 494
Bit Score: 1044.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 27 SEE QE TDV L LIGGGIMSATLGT Y L R ELEPEWS M TM V ERL E GVA Q ESSNGWNNAGTGHSAL M ELNYTP QN ADGSI S I E KAV 106
Cdd:PRK05257 1 SEE SK TDV V LIGGGIMSATLGT L L K ELEPEWS I TM F ERL D GVA L ESSNGWNNAGTGHSAL C ELNYTP EK ADGSI D I S KAV 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 107 A INE A FQISRQFWA HQ VE R GVL RT PRSFIN T VPHMSFVWGEDNV N FL RA RY A AL QQSS LF R GM RY SED H AQIKEWAPL V M 186
Cdd:PRK05257 81 K INE Q FQISRQFWA YL VE K GVL PD PRSFIN P VPHMSFVWGEDNV A FL KK RY E AL KANP LF A GM EF SED P AQIKEWAPL M M 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 187 EGRDP Q QKVAATR T EIGTDVN Y G EI TRQL IAS LQK KS NF S LQL SS EVR AL KRNDD NT WTVTV A DLK N G TAQNI RAKFVFI 266
Cdd:PRK05257 161 EGRDP S QKVAATR I EIGTDVN F G AL TRQL VGY LQK QG NF E LQL GH EVR DI KRNDD GS WTVTV K DLK T G EKRTV RAKFVFI 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 267 GAGG A AL K LLQ E SGIPEAK D Y A GFPV G GQFLV S ENP D VV NH H L AKVYGKASVGAPPMSVPH I DTRV L DGKR VV LFGPFA T 346
Cdd:PRK05257 241 GAGG G AL P LLQ K SGIPEAK G Y G GFPV S GQFLV C ENP E VV AQ H H AKVYGKASVGAPPMSVPH L DTRV I DGKR SL LFGPFA G 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 347 FSTKFLKNGSL W DL M SS TTT SN VM PM MH VGLDNFDL V KYL V SQVMLS E EDRFEAL K E Y YP Q AK K EDW R L WQ AGQRVQIIK 426
Cdd:PRK05257 321 FSTKFLKNGSL L DL F SS VRP SN LL PM LA VGLDNFDL T KYL I SQVMLS D EDRFEAL R E F YP N AK P EDW E L IV AGQRVQIIK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 427 R D AE KGGVL RL GTEVVS DQQ G T IAALLGASPGASTA A PIML DL LEK V F G DR VS SP Q WQ AT LK AIV PSYG R KLN GDV A AT E 506
Cdd:PRK05257 401 K D PK KGGVL QF GTEVVS SAD G S IAALLGASPGASTA V PIML EV LEK C F P DR MA SP E WQ PK LK EMI PSYG Q KLN DNP A LL E 480
490
....*....|....
gi 446680727 507 RELQ YTSEVLGL K Y 520
Cdd:PRK05257 481 EIRA YTSEVLGL D Y 494
Name
Accession
Description
Interval
E-value
PRK05257
PRK05257 malate:quinone oxidoreductase; Validated
27-520
0e+00
malate:quinone oxidoreductase; Validated
Pssm-ID: 179979
Cd Length: 494
Bit Score: 1044.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 27 SEE QE TDV L LIGGGIMSATLGT Y L R ELEPEWS M TM V ERL E GVA Q ESSNGWNNAGTGHSAL M ELNYTP QN ADGSI S I E KAV 106
Cdd:PRK05257 1 SEE SK TDV V LIGGGIMSATLGT L L K ELEPEWS I TM F ERL D GVA L ESSNGWNNAGTGHSAL C ELNYTP EK ADGSI D I S KAV 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 107 A INE A FQISRQFWA HQ VE R GVL RT PRSFIN T VPHMSFVWGEDNV N FL RA RY A AL QQSS LF R GM RY SED H AQIKEWAPL V M 186
Cdd:PRK05257 81 K INE Q FQISRQFWA YL VE K GVL PD PRSFIN P VPHMSFVWGEDNV A FL KK RY E AL KANP LF A GM EF SED P AQIKEWAPL M M 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 187 EGRDP Q QKVAATR T EIGTDVN Y G EI TRQL IAS LQK KS NF S LQL SS EVR AL KRNDD NT WTVTV A DLK N G TAQNI RAKFVFI 266
Cdd:PRK05257 161 EGRDP S QKVAATR I EIGTDVN F G AL TRQL VGY LQK QG NF E LQL GH EVR DI KRNDD GS WTVTV K DLK T G EKRTV RAKFVFI 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 267 GAGG A AL K LLQ E SGIPEAK D Y A GFPV G GQFLV S ENP D VV NH H L AKVYGKASVGAPPMSVPH I DTRV L DGKR VV LFGPFA T 346
Cdd:PRK05257 241 GAGG G AL P LLQ K SGIPEAK G Y G GFPV S GQFLV C ENP E VV AQ H H AKVYGKASVGAPPMSVPH L DTRV I DGKR SL LFGPFA G 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 347 FSTKFLKNGSL W DL M SS TTT SN VM PM MH VGLDNFDL V KYL V SQVMLS E EDRFEAL K E Y YP Q AK K EDW R L WQ AGQRVQIIK 426
Cdd:PRK05257 321 FSTKFLKNGSL L DL F SS VRP SN LL PM LA VGLDNFDL T KYL I SQVMLS D EDRFEAL R E F YP N AK P EDW E L IV AGQRVQIIK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 427 R D AE KGGVL RL GTEVVS DQQ G T IAALLGASPGASTA A PIML DL LEK V F G DR VS SP Q WQ AT LK AIV PSYG R KLN GDV A AT E 506
Cdd:PRK05257 401 K D PK KGGVL QF GTEVVS SAD G S IAALLGASPGASTA V PIML EV LEK C F P DR MA SP E WQ PK LK EMI PSYG Q KLN DNP A LL E 480
490
....*....|....
gi 446680727 507 RELQ YTSEVLGL K Y 520
Cdd:PRK05257 481 EIRA YTSEVLGL D Y 494
Mqo
pfam06039 Malate:quinone oxidoreductase (Mqo); This family consists of several bacterial Malate:quinone ...
31-518
0e+00
Malate:quinone oxidoreductase (Mqo); This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.
Pssm-ID: 461809
Cd Length: 488
Bit Score: 1016.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 31 ET DV L LIG G GIMSATLGT Y L R ELEP E WS M T MV ERL EG VA Q ESSN G WNNAGTGHSAL M ELNYTP QNA DGSI S I E KAV A INE 110
Cdd:pfam06039 1 KV DV V LIG A GIMSATLGT L L K ELEP D WS I T VF ERL DA VA A ESSN A WNNAGTGHSAL C ELNYTP EKP DGSI D I S KAV K INE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 111 A F QI SRQFWA HQ VE R GVL RT P R SFIN T VPHMSFVWGEDNV N FLR A RY A AL QQSS LF R GM RY SED H AQI K EWAPL V MEGRD 190
Cdd:pfam06039 81 Q F EV SRQFWA YL VE N GVL PD P K SFIN P VPHMSFVWGEDNV A FLR K RY E AL SAHP LF E GM EF SED P AQI A EWAPL M MEGRD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 191 P QQK VAATR T E I GTDVN Y G EI TRQL I A S LQK KSNFS L QLSS EV RA LKRN D D NT W T V T V A DL KN G TAQNI RAKFVFIGAGG 270
Cdd:pfam06039 161 P SEP VAATR I E L GTDVN F G AL TRQL V A Y LQK QPGVE L HYGH EV TD LKRN S D GR W R V K V K DL NT G EKRTV RAKFVFIGAGG 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 271 A AL K LLQ E SGIPEAK D Y A GFPV G GQFL VSE NP D V VNH H L AKVYGKA S VGAPPMSVPH I DTRV L DGK RVV LFGPFA T FSTK 350
Cdd:pfam06039 241 G AL P LLQ K SGIPEAK G Y G GFPV S GQFL RCT NP E V IAQ H H AKVYGKA A VGAPPMSVPH L DTRV I DGK KSL LFGPFA G FSTK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 351 FLKNGSL W DL MS S TTT SN VM PM MH VGLDN F DL V KYL VS QV ML S E EDR F EAL K E YY P Q AK K EDW R L WQ AGQRVQ I IK R D A E 430
Cdd:pfam06039 321 FLKNGSL L DL FK S IRP SN IL PM LA VGLDN L DL T KYL IG QV LQ S H EDR M EAL R E FF P E AK D EDW E L IT AGQRVQ V IK K D E E 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 431 KGGVL RL GTEVV SDQQ G T IAALLGASPGASTA AP IML DL LE KV F GD R VS SP Q WQ AT LK AIV PSYG R KLN G D VAATERELQ 510
Cdd:pfam06039 401 KGGVL QF GTEVV ASAD G S IAALLGASPGASTA VS IML EV LE RC F PE R MA SP E WQ PK LK EMI PSYG Q KLN D D PELLAEIRA 480
....*...
gi 446680727 511 Y TS E VLGL 518
Cdd:pfam06039 481 R TS K VLGL 488
mal_quin_oxido
TIGR01320 malate:quinone-oxidoreductase; This membrane-associated enzyme is an alternative to the ...
32-516
0e+00
malate:quinone-oxidoreductase; This membrane-associated enzyme is an alternative to the better-known NAD-dependent malate dehydrogenase as part of the TCA cycle. The reduction of a quinone rather than NAD+ makes the reaction essentially irreversible in the direction of malate oxidation to oxaloacetate. Both forms of malate dehydrogenase are active in E. coli; disruption of this form causes less phenotypic change. In some bacteria, this form is the only or the more important malate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 130387
Cd Length: 483
Bit Score: 686.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 32 TDV L LIG G GIMSATLG TY LRELEP E WS M T MV ERL EG VA Q ESSN G WNNAGTGHSAL M ELNYTP QN ADGSI S I E KAV A INE A 111
Cdd:TIGR01320 1 TDV V LIG A GIMSATLG VL LRELEP N WS I T LI ERL DA VA A ESSN P WNNAGTGHSAL C ELNYTP EM ADGSI D I A KAV G INE Q 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 112 FQ I SRQFWAH Q VE R G V L RT P R SFIN T VPH M SFV W G E D N V NF L RA RY A AL QQSS LF R GM RY SED H A QIK EW A PL VME GRD P 191
Cdd:TIGR01320 81 FQ V SRQFWAH L VE E G I L TD P K SFIN P VPH V SFV H G S D G V AY L KK RY E AL KGHP LF E GM EF SED P A TFA EW L PL MAA GRD F 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 192 QQK VAA TRTEI GTDV NY G EI T R QL IAS L QKKSN f SLQLSS EVR A LKR ND D NT WTVTV ADLKN G TAQNIRAK FVF I GAGG A 271
Cdd:TIGR01320 161 SEP VAA NWAAE GTDV DF G AL T K QL LGY L VQNGT - TIRFGH EVR N LKR QS D GS WTVTV KNTRT G GKRTLNTR FVF V GAGG G 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 272 AL K LLQ E SGIPE A K DY AGFPV G G Q FL VSE NP DVVNH H L AKVYG K ASVGAPPMSVPH I DTRV L DGK RVV LFGP F A TF S T KF 351
Cdd:TIGR01320 240 AL P LLQ K SGIPE V K GF AGFPV S G L FL RCG NP ELTEQ H R AKVYG Q ASVGAPPMSVPH L DTRV V DGK KWL LFGP Y A GW S P KF 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 352 LK N GS LW DL MS S TTTS N VMP M MH VGL DNF DL V KYL VS Q VML SEE D R FE AL K E Y YP Q A KKE DW R L WQ AGQRVQ I IK R D A EK 431
Cdd:TIGR01320 320 LK H GS IL DL PL S IRPD N LLS M LG VGL TEM DL T KYL IG Q LRK SEE E R VS AL R E F YP E A IDS DW E L IV AGQRVQ V IK K D P EK 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 432 G - GVL RL GT EVVS D QQ G T IA A LLGASPGASTA AP IMLDLLE KV F GD R vs SPQ W QAT LK AI VPSYG R KL NGDV A ATERELQ 510
Cdd:TIGR01320 400 G g GVL EF GT TLIA D AD G S IA G LLGASPGASTA VS IMLDLLE RC F PE R -- YQS W LPK LK EM VPSYG K KL SSEP A LFDEVWS 477
....*.
gi 446680727 511 Y T SE VL 516
Cdd:TIGR01320 478 R T TK VL 483
LhgO
COG0579 L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
28-506
2.30e-154
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
Pssm-ID: 440344 [Multi-domain]
Cd Length: 418
Bit Score: 447.67
E-value: 2.30e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 28 EEQET DV LL IG G GI MSAT L GTY L REL E p EWSMTMV E RLEG VAQESS N gw NN A G TG H SA L mel N YTP qnad GS ISIEKA V A 107
Cdd:COG0579 1 MMEMY DV VI IG A GI VGLA L ARE L SRY E - DLKVLVL E KEDD VAQESS G -- NN S G VI H AG L --- Y YTP ---- GS LKARLC V E 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 108 I NE A F - QIS R Q fwa HQVE rgvlrtprsf INTVPHMSFVW GE DN V N FL RAR Y AALQQS s LFR G MRYS e D HAQIK E WA PL VM 186
Cdd:COG0579 71 G NE L F y ELC R E --- LGIP ---------- FKRCGKLVVAT GE EE V A FL EKL Y ERGKAN - GVP G LEIL - D REELR E LE PL LS 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 187 E grdpq QK VAA TRTEIGTD V NY G EI TR Q L IASLQKK s NFS L Q L SS EV RALK R ND D N t W T VT VA dlk N GT aqn IRA K FV FI 266
Cdd:COG0579 136 D ----- EG VAA LYSPSTGI V DP G AL TR A L AENAEAN - GVE L L L NT EV TGIE R EG D G - W E VT TN --- G GT --- IRA R FV IN 202
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 267 G AG GA A LK L L Q ES GI pe A KD YAG FPV G G QF LV SEN P - DV VN H hla KVY GKASV GAP PMS V p H I d TR VL DG K rv V LFGP F A 345
Cdd:COG0579 203 A AG LY A DR L A Q MA GI -- G KD FGI FPV K G EY LV LDK P a EL VN A --- KVY PVPDP GAP FLG V - H L - TR TI DG N -- L LFGP N A 273
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 346 T F ST K fl K NG SL W DL MS S TTTS N VM PM MH vgl D N F d L V KYL V S QVM LS E E DRF EAL KE Y Y P QAKK ED WRLWQ AG Q R V QII 425
Cdd:COG0579 274 V F VP K -- K ED SL L DL FE S LRFP N FW PM LA --- K N L - L T KYL E S VTS LS K E AFL EAL RK Y V P ELPD ED LIPAF AG I R A QII 347
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 426 K R D aekggvlrl G TE V V -- S D QQ G T I AA L LGA SPGA ST A AP I MLDLL E K v FGDRVSSPQ WQ ATL K A I vp S Y G r K L NG D V A 503
Cdd:COG0579 348 K P D --------- G DF V I ee A D DP G S I HV L GIE SPGA TS A LA I AEHVA E L - LPEKLEEKD WQ PKR K M I -- S F G - E L KE D P A 414
...
gi 446680727 504 AT E 506
Cdd:COG0579 415 YG E 417
Name
Accession
Description
Interval
E-value
PRK05257
PRK05257 malate:quinone oxidoreductase; Validated
27-520
0e+00
malate:quinone oxidoreductase; Validated
Pssm-ID: 179979
Cd Length: 494
Bit Score: 1044.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 27 SEE QE TDV L LIGGGIMSATLGT Y L R ELEPEWS M TM V ERL E GVA Q ESSNGWNNAGTGHSAL M ELNYTP QN ADGSI S I E KAV 106
Cdd:PRK05257 1 SEE SK TDV V LIGGGIMSATLGT L L K ELEPEWS I TM F ERL D GVA L ESSNGWNNAGTGHSAL C ELNYTP EK ADGSI D I S KAV 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 107 A INE A FQISRQFWA HQ VE R GVL RT PRSFIN T VPHMSFVWGEDNV N FL RA RY A AL QQSS LF R GM RY SED H AQIKEWAPL V M 186
Cdd:PRK05257 81 K INE Q FQISRQFWA YL VE K GVL PD PRSFIN P VPHMSFVWGEDNV A FL KK RY E AL KANP LF A GM EF SED P AQIKEWAPL M M 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 187 EGRDP Q QKVAATR T EIGTDVN Y G EI TRQL IAS LQK KS NF S LQL SS EVR AL KRNDD NT WTVTV A DLK N G TAQNI RAKFVFI 266
Cdd:PRK05257 161 EGRDP S QKVAATR I EIGTDVN F G AL TRQL VGY LQK QG NF E LQL GH EVR DI KRNDD GS WTVTV K DLK T G EKRTV RAKFVFI 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 267 GAGG A AL K LLQ E SGIPEAK D Y A GFPV G GQFLV S ENP D VV NH H L AKVYGKASVGAPPMSVPH I DTRV L DGKR VV LFGPFA T 346
Cdd:PRK05257 241 GAGG G AL P LLQ K SGIPEAK G Y G GFPV S GQFLV C ENP E VV AQ H H AKVYGKASVGAPPMSVPH L DTRV I DGKR SL LFGPFA G 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 347 FSTKFLKNGSL W DL M SS TTT SN VM PM MH VGLDNFDL V KYL V SQVMLS E EDRFEAL K E Y YP Q AK K EDW R L WQ AGQRVQIIK 426
Cdd:PRK05257 321 FSTKFLKNGSL L DL F SS VRP SN LL PM LA VGLDNFDL T KYL I SQVMLS D EDRFEAL R E F YP N AK P EDW E L IV AGQRVQIIK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 427 R D AE KGGVL RL GTEVVS DQQ G T IAALLGASPGASTA A PIML DL LEK V F G DR VS SP Q WQ AT LK AIV PSYG R KLN GDV A AT E 506
Cdd:PRK05257 401 K D PK KGGVL QF GTEVVS SAD G S IAALLGASPGASTA V PIML EV LEK C F P DR MA SP E WQ PK LK EMI PSYG Q KLN DNP A LL E 480
490
....*....|....
gi 446680727 507 RELQ YTSEVLGL K Y 520
Cdd:PRK05257 481 EIRA YTSEVLGL D Y 494
Mqo
pfam06039 Malate:quinone oxidoreductase (Mqo); This family consists of several bacterial Malate:quinone ...
31-518
0e+00
Malate:quinone oxidoreductase (Mqo); This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.
Pssm-ID: 461809
Cd Length: 488
Bit Score: 1016.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 31 ET DV L LIG G GIMSATLGT Y L R ELEP E WS M T MV ERL EG VA Q ESSN G WNNAGTGHSAL M ELNYTP QNA DGSI S I E KAV A INE 110
Cdd:pfam06039 1 KV DV V LIG A GIMSATLGT L L K ELEP D WS I T VF ERL DA VA A ESSN A WNNAGTGHSAL C ELNYTP EKP DGSI D I S KAV K INE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 111 A F QI SRQFWA HQ VE R GVL RT P R SFIN T VPHMSFVWGEDNV N FLR A RY A AL QQSS LF R GM RY SED H AQI K EWAPL V MEGRD 190
Cdd:pfam06039 81 Q F EV SRQFWA YL VE N GVL PD P K SFIN P VPHMSFVWGEDNV A FLR K RY E AL SAHP LF E GM EF SED P AQI A EWAPL M MEGRD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 191 P QQK VAATR T E I GTDVN Y G EI TRQL I A S LQK KSNFS L QLSS EV RA LKRN D D NT W T V T V A DL KN G TAQNI RAKFVFIGAGG 270
Cdd:pfam06039 161 P SEP VAATR I E L GTDVN F G AL TRQL V A Y LQK QPGVE L HYGH EV TD LKRN S D GR W R V K V K DL NT G EKRTV RAKFVFIGAGG 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 271 A AL K LLQ E SGIPEAK D Y A GFPV G GQFL VSE NP D V VNH H L AKVYGKA S VGAPPMSVPH I DTRV L DGK RVV LFGPFA T FSTK 350
Cdd:pfam06039 241 G AL P LLQ K SGIPEAK G Y G GFPV S GQFL RCT NP E V IAQ H H AKVYGKA A VGAPPMSVPH L DTRV I DGK KSL LFGPFA G FSTK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 351 FLKNGSL W DL MS S TTT SN VM PM MH VGLDN F DL V KYL VS QV ML S E EDR F EAL K E YY P Q AK K EDW R L WQ AGQRVQ I IK R D A E 430
Cdd:pfam06039 321 FLKNGSL L DL FK S IRP SN IL PM LA VGLDN L DL T KYL IG QV LQ S H EDR M EAL R E FF P E AK D EDW E L IT AGQRVQ V IK K D E E 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 431 KGGVL RL GTEVV SDQQ G T IAALLGASPGASTA AP IML DL LE KV F GD R VS SP Q WQ AT LK AIV PSYG R KLN G D VAATERELQ 510
Cdd:pfam06039 401 KGGVL QF GTEVV ASAD G S IAALLGASPGASTA VS IML EV LE RC F PE R MA SP E WQ PK LK EMI PSYG Q KLN D D PELLAEIRA 480
....*...
gi 446680727 511 Y TS E VLGL 518
Cdd:pfam06039 481 R TS K VLGL 488
PRK13339
PRK13339 malate:quinone oxidoreductase; Reviewed
26-520
0e+00
malate:quinone oxidoreductase; Reviewed
Pssm-ID: 183983
Cd Length: 497
Bit Score: 710.31
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 26 ASEEQET DV L L I G G GI M S A T L G TY L R EL E P E W SMTM VERL EGV A Q ESSN G WNNAGTGH S AL M ELNYT P Q NA DGSI S IEKA 105
Cdd:PRK13339 1 MAKSESK DV V L V G A GI L S T T F G VL L K EL D P D W NIEV VERL DSP A I ESSN E WNNAGTGH A AL C ELNYT V Q QP DGSI D IEKA 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 106 VA INE A F Q IS R QFW A H Q V ER G VLRT PR S FIN TV PH M SFV W G ED NV N FL RA RY A AL Q Q SSL F RGMR Y S ED HAQIKE W A PL V 185
Cdd:PRK13339 81 KE INE Q F E IS K QFW G H L V KS G TIGN PR E FIN PL PH I SFV R G KN NV K FL KK RY E AL K Q HPM F DNIE Y T ED IEVMAK W M PL M 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 186 M E GR DPQQKV AA TRTEI GTDVN Y G EI TR Q L IAS L QKKS N FSLQLSS EV RA L K R ND D NT W T VTV A D LKN G TAQNIR A KF VF 265
Cdd:PRK13339 161 M P GR EANEIM AA SKIDE GTDVN F G AL TR K L AKH L ESHP N AQVKYNH EV VD L E R LS D GG W E VTV K D RNT G EKREQV A DY VF 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 266 IGAGG A A LK LLQ E SGIPE A K DYA GFP VG GQFL VSE NP D VV NH H L AKVY G K AS VG A PPM S VPH I DTR VL DGKR VV LFGP F A 345
Cdd:PRK13339 241 IGAGG G A IP LLQ K SGIPE S K HLG GFP IS GQFL RCT NP E VV KQ H Q AKVY S K EP VG T PPM T VPH L DTR YI DGKR SL LFGP Y A 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 346 T F ST KFLK N GS LW DL MS S TTTS N VMP M MH V GLD N FD L V KY LVS QVM LSE E D R FEA L KEY YP Q A KK EDWRL WQ AG Q RVQ I I 425
Cdd:PRK13339 321 G F GP KFLK H GS NL DL FK S VKPY N ITT M LA V AVK N MP L I KY SID QVM QTK E G R MNH L RTF YP E A RA EDWRL YT AG K RVQ V I 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 426 K RDA E K G - G VLRL GTEVV SD Q QGTIA ALLG A SPGAST AAPIM L DL LE KV F GDRVS sp Q W QAT LK AIV PSYG RK L NG D VAA 504
Cdd:PRK13339 401 K DTP E H G k G FIQF GTEVV NS Q DHSVI ALLG E SPGAST SVSVA L EV LE RN F PEYAK -- E W APK LK EMI PSYG KS L IE D AKL 478
490
....*....|....*.
gi 446680727 505 TERELQY TS EV L G L K Y 520
Cdd:PRK13339 479 MRKIRKQ TS KD L E L G Y 494
mal_quin_oxido
TIGR01320 malate:quinone-oxidoreductase; This membrane-associated enzyme is an alternative to the ...
32-516
0e+00
malate:quinone-oxidoreductase; This membrane-associated enzyme is an alternative to the better-known NAD-dependent malate dehydrogenase as part of the TCA cycle. The reduction of a quinone rather than NAD+ makes the reaction essentially irreversible in the direction of malate oxidation to oxaloacetate. Both forms of malate dehydrogenase are active in E. coli; disruption of this form causes less phenotypic change. In some bacteria, this form is the only or the more important malate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 130387
Cd Length: 483
Bit Score: 686.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 32 TDV L LIG G GIMSATLG TY LRELEP E WS M T MV ERL EG VA Q ESSN G WNNAGTGHSAL M ELNYTP QN ADGSI S I E KAV A INE A 111
Cdd:TIGR01320 1 TDV V LIG A GIMSATLG VL LRELEP N WS I T LI ERL DA VA A ESSN P WNNAGTGHSAL C ELNYTP EM ADGSI D I A KAV G INE Q 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 112 FQ I SRQFWAH Q VE R G V L RT P R SFIN T VPH M SFV W G E D N V NF L RA RY A AL QQSS LF R GM RY SED H A QIK EW A PL VME GRD P 191
Cdd:TIGR01320 81 FQ V SRQFWAH L VE E G I L TD P K SFIN P VPH V SFV H G S D G V AY L KK RY E AL KGHP LF E GM EF SED P A TFA EW L PL MAA GRD F 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 192 QQK VAA TRTEI GTDV NY G EI T R QL IAS L QKKSN f SLQLSS EVR A LKR ND D NT WTVTV ADLKN G TAQNIRAK FVF I GAGG A 271
Cdd:TIGR01320 161 SEP VAA NWAAE GTDV DF G AL T K QL LGY L VQNGT - TIRFGH EVR N LKR QS D GS WTVTV KNTRT G GKRTLNTR FVF V GAGG G 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 272 AL K LLQ E SGIPE A K DY AGFPV G G Q FL VSE NP DVVNH H L AKVYG K ASVGAPPMSVPH I DTRV L DGK RVV LFGP F A TF S T KF 351
Cdd:TIGR01320 240 AL P LLQ K SGIPE V K GF AGFPV S G L FL RCG NP ELTEQ H R AKVYG Q ASVGAPPMSVPH L DTRV V DGK KWL LFGP Y A GW S P KF 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 352 LK N GS LW DL MS S TTTS N VMP M MH VGL DNF DL V KYL VS Q VML SEE D R FE AL K E Y YP Q A KKE DW R L WQ AGQRVQ I IK R D A EK 431
Cdd:TIGR01320 320 LK H GS IL DL PL S IRPD N LLS M LG VGL TEM DL T KYL IG Q LRK SEE E R VS AL R E F YP E A IDS DW E L IV AGQRVQ V IK K D P EK 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 432 G - GVL RL GT EVVS D QQ G T IA A LLGASPGASTA AP IMLDLLE KV F GD R vs SPQ W QAT LK AI VPSYG R KL NGDV A ATERELQ 510
Cdd:TIGR01320 400 G g GVL EF GT TLIA D AD G S IA G LLGASPGASTA VS IMLDLLE RC F PE R -- YQS W LPK LK EM VPSYG K KL SSEP A LFDEVWS 477
....*.
gi 446680727 511 Y T SE VL 516
Cdd:TIGR01320 478 R T TK VL 483
LhgO
COG0579 L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
28-506
2.30e-154
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
Pssm-ID: 440344 [Multi-domain]
Cd Length: 418
Bit Score: 447.67
E-value: 2.30e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 28 EEQET DV LL IG G GI MSAT L GTY L REL E p EWSMTMV E RLEG VAQESS N gw NN A G TG H SA L mel N YTP qnad GS ISIEKA V A 107
Cdd:COG0579 1 MMEMY DV VI IG A GI VGLA L ARE L SRY E - DLKVLVL E KEDD VAQESS G -- NN S G VI H AG L --- Y YTP ---- GS LKARLC V E 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 108 I NE A F - QIS R Q fwa HQVE rgvlrtprsf INTVPHMSFVW GE DN V N FL RAR Y AALQQS s LFR G MRYS e D HAQIK E WA PL VM 186
Cdd:COG0579 71 G NE L F y ELC R E --- LGIP ---------- FKRCGKLVVAT GE EE V A FL EKL Y ERGKAN - GVP G LEIL - D REELR E LE PL LS 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 187 E grdpq QK VAA TRTEIGTD V NY G EI TR Q L IASLQKK s NFS L Q L SS EV RALK R ND D N t W T VT VA dlk N GT aqn IRA K FV FI 266
Cdd:COG0579 136 D ----- EG VAA LYSPSTGI V DP G AL TR A L AENAEAN - GVE L L L NT EV TGIE R EG D G - W E VT TN --- G GT --- IRA R FV IN 202
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 267 G AG GA A LK L L Q ES GI pe A KD YAG FPV G G QF LV SEN P - DV VN H hla KVY GKASV GAP PMS V p H I d TR VL DG K rv V LFGP F A 345
Cdd:COG0579 203 A AG LY A DR L A Q MA GI -- G KD FGI FPV K G EY LV LDK P a EL VN A --- KVY PVPDP GAP FLG V - H L - TR TI DG N -- L LFGP N A 273
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 346 T F ST K fl K NG SL W DL MS S TTTS N VM PM MH vgl D N F d L V KYL V S QVM LS E E DRF EAL KE Y Y P QAKK ED WRLWQ AG Q R V QII 425
Cdd:COG0579 274 V F VP K -- K ED SL L DL FE S LRFP N FW PM LA --- K N L - L T KYL E S VTS LS K E AFL EAL RK Y V P ELPD ED LIPAF AG I R A QII 347
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 426 K R D aekggvlrl G TE V V -- S D QQ G T I AA L LGA SPGA ST A AP I MLDLL E K v FGDRVSSPQ WQ ATL K A I vp S Y G r K L NG D V A 503
Cdd:COG0579 348 K P D --------- G DF V I ee A D DP G S I HV L GIE SPGA TS A LA I AEHVA E L - LPEKLEEKD WQ PKR K M I -- S F G - E L KE D P A 414
...
gi 446680727 504 AT E 506
Cdd:COG0579 415 YG E 417
PTZ00383
PTZ00383 malate:quinone oxidoreductase; Provisional
33-461
7.79e-21
malate:quinone oxidoreductase; Provisional
Pssm-ID: 240393 [Multi-domain]
Cd Length: 497
Bit Score: 95.57
E-value: 7.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 33 DV LLI GGG IMSAT L GTY L RELEPEWSMTMV ER LEGV A QES S N G W NN AG T G H SALM E L NYT P qnadgsisi EKA VAINEAF 112
Cdd:PTZ00383 47 DV VIV GGG VTGTA L FYT L SKFTNLKKIALI ER RSDF A LVA S H G K NN SQ T I H CGDI E T NYT L --------- EKA RKVKRQA 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 113 QIS R QFWAH -- QV ER gvlrtp R S F I NTVPH M SFVW GE DNVN FL RA RY AALQQ ss LF RG M RYSEDH a Q I KEWA P L V MEGRD 190
Cdd:PTZ00383 118 DML R NYLTK lp PS ER ------ D S I I FKMQK M VLGV GE KECE FL EK RY PVFKE -- LF PS M QLLDKK - E I HRVE P R V VLKNN 188
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 191 ---- PQQKV A ATRTEIG T D V N Y GEITRQLIASLQKKSN ----- F S LQ L SS EV RALK R ND D NTWTVTV adl KN G T aqn IRA 261
Cdd:PTZ00383 189 htlr EEPLA A LYVPNEL T T V D Y QKLSESFVKHARRDAL vpgkk I S IN L NT EV LNIE R SN D SLYKIHT --- NR G E --- IRA 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 262 K FV FIG A G G AA L KLL Q ES G I pe AKD Y AGF PV G G Q F LV S en PDVV N hhl A KVY gka S V GA P -- P MSVP H I D TR - VLD GK rv 338
Cdd:PTZ00383 263 R FV VVS A C G YS L LFA Q KM G Y -- GLE Y SCL PV A G S F YF S -- GNIL N --- G KVY --- T V QN P al P FAAV H G D PD i IAK GK -- 330
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 339 VL FGP F A TFSTKFLKN -- G SL W D LMS stt TS N VMP - MMH V GL D N F --- DLV KY LVSQVM ----- L SEEDRFEALKEYY P Q 407
Cdd:PTZ00383 331 TR FGP T A LPLPLLERY nm S SL P D FLK --- VW N PDL n LLA V YF D L F kds TMR KY VLRNFL fevpl L NKYLFLKDARKIV P S 407
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 446680727 408 AKKE D W R LWQA -- G Q R V Q I I KRDAE K ggv L R LG TEVVSDQQ G T I AALL g A SPGA S T 461
Cdd:PTZ00383 408 LTRK D L R YCVG yg G V R P Q L I DKVSK K --- L L LG EGKIDPGK G I I FNIT - P SPGA T T 459
DadA
COG0665 Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
30-303
3.69e-08
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
Pssm-ID: 440429 [Multi-domain]
Cd Length: 364
Bit Score: 55.68
E-value: 3.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 30 QET DV LL IGGGI MSATLGTY L REL ep EWSM T MV ER l EGVAQES S ng WN NAG tghsalmel NYT P QN A D gs ISIEKA V AIN 109
Cdd:COG0665 1 ATA DV VV IGGGI AGLSTAYH L ARR -- GLDV T VL ER - GRPGSGA S -- GR NAG --------- QLR P GL A A -- LADRAL V RLA 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 110 EA fqi SRQF W AHQVERGVLRTP rsf INTVPHMSFVWG E DNVNF LRA RYA AL QQ sslf R G MRYSE - D H A QIK E WA P LV meg 188
Cdd:COG0665 65 RE --- ALDL W RELAAELGIDCD --- FRRTGVLYLART E AELAA LRA EAE AL RA ---- L G LPVEL l D A A ELR E RE P GL --- 131
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 189 r DPQQKVAATRTEIGTD V NYGEIT R Q L IASLQKK s NFSLQLSSE V RA L K R NDDNTWT V TVAD lkn GT aqn I RA KF V FIG A 268
Cdd:COG0665 132 - GSPDYAGGLYDPDDGH V DPAKLV R A L ARAARAA - GVRIREGTP V TG L E R EGGRVTG V RTER --- GT --- V RA DA V VLA A 203
250 260 270
....*....|....*....|....*....|....*
gi 446680727 269 G GAALK LL QES G I peak DYAGF PV G G QF LV S E NPD 303
Cdd:COG0665 204 G AWSAR LL PML G L ---- RLPLR PV R G YV LV T E PLP 234
mnmC
PRK01747 bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
24-295
9.79e-05
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;
Pssm-ID: 234978 [Multi-domain]
Cd Length: 662
Bit Score: 45.22
E-value: 9.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 24 A KASEEQET D VLL IGGGI MS A T lg TY L RELEPE W SM T MV E RL E GV AQ ES S N gw N NA G tghs AL M elnyt P Q - NA D GSISI 102
Cdd:PRK01747 253 A RPGSPKAR D AAI IGGGI AG A A -- LA L ALARRG W QV T LY E AD E AP AQ GA S G -- N RQ G ---- AL Y ----- P L l SK D DNALS 319
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 103 EKAV A ine AF QIS R Q F WAHQVER GV l RTPRSF i NT V PH ms FV W G E DNVNFLRARY A ALQQSS L F R GM rysedhaqikewa 182
Cdd:PRK01747 320 RFFR A --- AF LFA R R F YDALPAA GV - AFDHDW - CG V LQ -- LA W D E KSAEKIAKML A LGLPAE L A R AL ------------- 379
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446680727 183 plvmegr D PQQ kvaa TRTEI G TD V NY G ------------- E IT R Q L I A SLQKK sn FSLQLSS EV RA L K R N DD n T W T vtva 249
Cdd:PRK01747 380 ------- D AEE ---- AEELA G LP V PC G gifypqggwlcpa E LC R A L L A LAGQQ -- LTIHFGH EV AR L E R E DD - G W Q ---- 441
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446680727 250 d L KNGTAQNIR A KF V FIGA G GA A LKLL Q ESGI P eakdya GFP V G GQ 295
Cdd:PRK01747 442 - L DFAGGTLAS A PV V VLAN G HD A ARFA Q TAHL P ------ LYS V R GQ 480
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
