heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, ...
1-225
4.02e-96
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.
The actual alignment was detected with superfamily member TIGR03656:
Pssm-ID: 274705 [Multi-domain] Cd Length: 217 Bit Score: 279.48 E-value: 4.02e-96
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, ...
1-225
4.02e-96
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.
Pssm-ID: 274705 [Multi-domain] Cd Length: 217 Bit Score: 279.48 E-value: 4.02e-96
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
33-143
2.57e-27
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer
Pssm-ID: 428269 [Multi-domain] Cd Length: 116 Bit Score: 100.80 E-value: 2.57e-27
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; ...
33-147
9.66e-23
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.
Pssm-ID: 132993 [Multi-domain] Cd Length: 117 Bit Score: 88.91 E-value: 9.66e-23
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, ...
1-225
4.02e-96
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.
Pssm-ID: 274705 [Multi-domain] Cd Length: 217 Bit Score: 279.48 E-value: 4.02e-96
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
33-143
2.57e-27
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer
Pssm-ID: 428269 [Multi-domain] Cd Length: 116 Bit Score: 100.80 E-value: 2.57e-27
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; ...
33-147
9.66e-23
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.
Pssm-ID: 132993 [Multi-domain] Cd Length: 117 Bit Score: 88.91 E-value: 9.66e-23
sortase B signal domain, NPQTN class; This model represents one of the boutique (rare) sortase ...
189-221
5.42e-15
sortase B signal domain, NPQTN class; This model represents one of the boutique (rare) sortase signals, recognized by sortase B (SrtB) rather than by the housekeeping-type SrtA class sortase. This sequence, beginning NPQTN, shows little similarity to several other SrtB substrates.
Pssm-ID: 132112 Cd Length: 33 Bit Score: 66.30 E-value: 5.42e-15
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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