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Conserved domains on  [gi|446713503|ref|WP_000790845|]
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MULTISPECIES: DUF4878 domain-containing protein [Bacillales]

Protein Classification

nuclear transport factor 2 family protein( domain architecture ID 233)

nuclear transport factor 2 (NTF2) family protein, similar to Aspergillus flavus scytalone dehydratases, Pseudomonas putida benzene 1,2-dioxygenase subunit beta, and many other members with similar structural details but divergent functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NTF2_like super family cl09109
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ...
 24-124 3.46e-11

Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes.


The actual alignment was detected with superfamily member pfam12870:

Pssm-ID: 471850  Cd Length: 111  Bit Score: 56.04  E-value: 3.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446713503   24 ACGNNrNPEEVATAYFEDAKEGNVKDFGELFTPEAKKIVA----------FVGGNADLMKSVSKDLKSYKIRKVEEKNEI 93
Cdd:pfam12870   2 SCGEN-GPKDVVINFMKDIEEGNGDDAIKYLTEDTRDSDAkkekvkgkfkEAAAKAESKKEKFGGIDEVEIVDECEEGDT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 446713503   94 ATVTVDAVYKDNPKKVIVIELEKTDDGWKIS 124
Cdd:pfam12870  81 AIVTVFVRTKDGSEKKDTIELIKEDGEWKIS 111
 
Name Accession Description Interval E-value
DUF4878 pfam12870
Domain of unknown function (DUF4878); This is a family of putative lipoproteins from bacteria. ...
 24-124 3.46e-11

Domain of unknown function (DUF4878); This is a family of putative lipoproteins from bacteria. The family is probably related to the NTF2-like transpeptidase family.


Pssm-ID: 432842  Cd Length: 111  Bit Score: 56.04  E-value: 3.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446713503   24 ACGNNrNPEEVATAYFEDAKEGNVKDFGELFTPEAKKIVA----------FVGGNADLMKSVSKDLKSYKIRKVEEKNEI 93
Cdd:pfam12870   2 SCGEN-GPKDVVINFMKDIEEGNGDDAIKYLTEDTRDSDAkkekvkgkfkEAAAKAESKKEKFGGIDEVEIVDECEEGDT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 446713503   94 ATVTVDAVYKDNPKKVIVIELEKTDDGWKIS 124
Cdd:pfam12870  81 AIVTVFVRTKDGSEKKDTIELIKEDGEWKIS 111
SodC COG2032
Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism];
8-59 6.93e-03

Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 441635  Cd Length: 171  Bit Score: 34.46  E-value: 6.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446713503   8 MIMLTLVMIVSISALAACGNNRNPEEVATAYFEDAKEGNVK--------DFGELFTPEAK 59
Cdd:COG2032    1 MKKLLALLAAAALLLAACAQSAAAAKTATATLVDTGDGKVVgtvtftetPGGVLVTVELS 60
 
Name Accession Description Interval E-value
DUF4878 pfam12870
Domain of unknown function (DUF4878); This is a family of putative lipoproteins from bacteria. ...
 24-124 3.46e-11

Domain of unknown function (DUF4878); This is a family of putative lipoproteins from bacteria. The family is probably related to the NTF2-like transpeptidase family.


Pssm-ID: 432842  Cd Length: 111  Bit Score: 56.04  E-value: 3.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446713503   24 ACGNNrNPEEVATAYFEDAKEGNVKDFGELFTPEAKKIVA----------FVGGNADLMKSVSKDLKSYKIRKVEEKNEI 93
Cdd:pfam12870   2 SCGEN-GPKDVVINFMKDIEEGNGDDAIKYLTEDTRDSDAkkekvkgkfkEAAAKAESKKEKFGGIDEVEIVDECEEGDT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 446713503   94 ATVTVDAVYKDNPKKVIVIELEKTDDGWKIS 124
Cdd:pfam12870  81 AIVTVFVRTKDGSEKKDTIELIKEDGEWKIS 111
Lumazine_bd_2 pfam12893
Putative lumazine-binding; This is a family of uncharacterized proteins. However, the family ...
 32-123 5.50e-03

Putative lumazine-binding; This is a family of uncharacterized proteins. However, the family belongs to the NTF2-like superfamily of various enzymes, and some of the members of the family are putative dehydrogenases.


Pssm-ID: 432859  Cd Length: 116  Bit Score: 34.20  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446713503   32 EEVATAYFEDAKEGNVKDFGELFTPEAkKIVAFVGGN------ADLMKSVSK--------DLKSYKIRKVEEKNEIATVT 97
Cdd:pfam12893   7 LAVLQDYFDGLYEGDPAKLRKAFHPDA-AIVGFTGGElvsmsrEEYIALVASrgspadegDPRERRIESIDVQGDVAMVK 85

                          90       100
                  ....*....|....*....|....*.
gi 446713503   98 VDAVYKDNpKKVIVIELEKTDDGWKI 123
Cdd:pfam12893  86 VELEWPGR-RFTDYLTLVKIDGEWRI 110
SodC COG2032
Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism];
8-59 6.93e-03

Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 441635  Cd Length: 171  Bit Score: 34.46  E-value: 6.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446713503   8 MIMLTLVMIVSISALAACGNNRNPEEVATAYFEDAKEGNVK--------DFGELFTPEAK 59
Cdd:COG2032    1 MKKLLALLAAAALLLAACAQSAAAAKTATATLVDTGDGKVVgtvtftetPGGVLVTVELS 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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