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Conserved domains on  [gi|446724127|ref|WP_000801440|]
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MULTISPECIES: DNA-binding transcriptional regulator [Gammaproteobacteria]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11459264)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
2-37 7.46e-07

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


:

Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 41.84  E-value: 7.46e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 446724127  2 KPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQK 37
Cdd:COG2944   3 KKPLTPEEIRALRERLGLSQAEFAALLGVSVSTVRR 38
 
Name Accession Description Interval E-value
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
2-37 7.46e-07

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 41.84  E-value: 7.46e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 446724127  2 KPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQK 37
Cdd:COG2944   3 KKPLTPEEIRALRERLGLSQAEFAALLGVSVSTVRR 38
VC1465_fam NF040522
VC1465 family Xer recombination activation factor;
10-39 1.39e-03

VC1465 family Xer recombination activation factor;


Pssm-ID: 439737 [Multi-domain]  Cd Length: 111  Bit Score: 34.35  E-value: 1.39e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 446724127  10 VKKLRLKAGLTQKECSHIYGVGLRTWQKKE 39
Cdd:NF040522   1 IKETREKAGLTRQQAAEMLRVSLRTVQNWE 30
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 6-39 8.63e-03

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 32.22  E-value: 8.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446724127    6 TPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKE 39
Cdd:TIGR03830  66 TGPEIRRIRKKLGLSQREAAELLGGGVNAFSRYE 99
 
Name Accession Description Interval E-value
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
2-37 7.46e-07

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 41.84  E-value: 7.46e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 446724127  2 KPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQK 37
Cdd:COG2944   3 KKPLTPEEIRALRERLGLSQAEFAALLGVSVSTVRR 38
VC1465_fam NF040522
VC1465 family Xer recombination activation factor;
10-39 1.39e-03

VC1465 family Xer recombination activation factor;


Pssm-ID: 439737 [Multi-domain]  Cd Length: 111  Bit Score: 34.35  E-value: 1.39e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 446724127  10 VKKLRLKAGLTQKECSHIYGVGLRTWQKKE 39
Cdd:NF040522   1 IKETREKAGLTRQQAAEMLRVSLRTVQNWE 30
CxxCG_CxxCG_HTH TIGR03830
putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of ...
 6-39 8.63e-03

putative zinc finger/helix-turn-helix protein, YgiT family; This model describes a family of predicted regulatory proteins with a conserved zinc finger/HTH architecture. The amino-terminal region contains a novel domain, featuring two CXXC motifs and occuring in a number of small bacterial proteins as well as in the present family. The carboxyl-terminal region consists of a helix-turn-helix domain, modeled by pfam01381. The predicted function is DNA binding and transcriptional regulation.


Pssm-ID: 274805 [Multi-domain]  Cd Length: 127  Bit Score: 32.22  E-value: 8.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446724127    6 TPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKE 39
Cdd:TIGR03830  66 TGPEIRRIRKKLGLSQREAAELLGGGVNAFSRYE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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