|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13054 |
PRK13054 |
lipid kinase; Reviewed |
2-299 |
0e+00 |
|
lipid kinase; Reviewed
Pssm-ID: 237281 [Multi-domain] Cd Length: 300 Bit Score: 544.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 2 AEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCE 81
Cdd:PRK13054 1 MTFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 82 GDDIPALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGG 161
Cdd:PRK13054 81 GDARPALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 162 VSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTG-DEILPALVSTLK 240
Cdd:PRK13054 161 VAYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPApQELLPTLLSTLT 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 241 S-DEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR 299
Cdd:PRK13054 241 GgSEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
|
|
| lip_kinase_YegS |
TIGR03702 |
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid ... |
6-298 |
2.26e-172 |
|
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 163414 Cd Length: 293 Bit Score: 478.45 E-value: 2.26e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 6 ASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDDI 85
Cdd:TIGR03702 1 KALLILNGKQADNEDVREAVGDLRDEGIQLHVRVTWEKGDAQRYVAEALALGVSTVIAGGGDGTLREVATALAQIRDDAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 86 PALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYI 165
Cdd:TIGR03702 81 PALGLLPLGTANDFATAAGIPLEPAKALKLALNGAAQPIDLARVNGKHYFLNMATGGFGTRVTTETSEKLKKALGGAAYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 166 IHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDN 245
Cdd:TIGR03702 161 ITGLTRFSELTAASCEFRGPDFHWEGDFLALGIGNGRQAGGGQVLCPDALINDGLLDVRILPAPELLPATLSTLFGGDKN 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 446730053 246 PNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLL 298
Cdd:TIGR03702 241 PEFVRARLPWLEIEAPQPLTFNLDGEPLSGRHFRIEVLPGALRCHLPPGCPLL 293
|
|
| LCB5 |
COG1597 |
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ... |
8-294 |
3.67e-82 |
|
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];
Pssm-ID: 441205 [Multi-domain] Cd Length: 295 Bit Score: 249.77 E-value: 3.67e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILN---GKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEgdd 84
Cdd:COG1597 6 LLIVNpasGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTG--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 85 iPALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQtCFINMATGGFGTRITTETPEKLKAALGGVSY 164
Cdd:COG1597 83 -PPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGR-YFLNVAGIGFDAEVVERANRALKRRLGKLAY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 165 IIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEI--LPALVSTLKSD 242
Cdd:COG1597 161 VLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRlrLLRLLPRLLRG 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446730053 243 E--DNPNIIEGASSWFDIQAPHEITFNLDGEPL-SGQNFHIEILPAALRCRLPPD 294
Cdd:COG1597 241 RhlRHPGVRYFRAREVEIESDRPLPVQLDGEPLgLATPLEFEVLPGALRVLVPAD 295
|
|
| DAGK_cat |
pfam00781 |
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ... |
8-129 |
1.49e-34 |
|
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.
Pssm-ID: 425868 [Multi-domain] Cd Length: 125 Bit Score: 121.92 E-value: 1.49e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILNGKSTDNLP---LREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIqcEGDD 84
Cdd:pfam00781 3 LVIVNPKSGGGKGkklLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLA--GLAT 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446730053 85 IPALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQV 129
Cdd:pfam00781 81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
|
|
| DAGKc |
smart00046 |
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ... |
8-131 |
7.92e-27 |
|
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Pssm-ID: 214487 [Multi-domain] Cd Length: 124 Bit Score: 101.60 E-value: 7.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILNGKSTDNLPLReAIMLLREEGMTIHVRVTWEKGDAARYVEeARKLGVA-TVIAGGGDGTINEVSTALIQCEGD-DI 85
Cdd:smart00046 1 LVFVNPKSGGGKGEK-LLRKFRLLLNPRQVFDLTKKGPAVALVI-FRDVPDFnRVLVCGGDGTVGWVLNALDKRELPlPE 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446730053 86 PALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNK 131
Cdd:smart00046 79 PPVAVLPLGTGNDLARSLGWGGGYDGEKLLKTLRDALESDTVKLDR 124
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13054 |
PRK13054 |
lipid kinase; Reviewed |
2-299 |
0e+00 |
|
lipid kinase; Reviewed
Pssm-ID: 237281 [Multi-domain] Cd Length: 300 Bit Score: 544.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 2 AEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCE 81
Cdd:PRK13054 1 MTFPKSLLILNGKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 82 GDDIPALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGG 161
Cdd:PRK13054 81 GDARPALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMATGGFGTRVTTETPEKLKAALGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 162 VSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTG-DEILPALVSTLK 240
Cdd:PRK13054 161 VAYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILPApQELLPTLLSTLT 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 241 S-DEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR 299
Cdd:PRK13054 241 GgSEDNPNIIRARLPWLEIQAPHELTFNLDGEPLSGRHFRIEVLPAALRCRLPPDCPLLR 300
|
|
| lip_kinase_YegS |
TIGR03702 |
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid ... |
6-298 |
2.26e-172 |
|
lipid kinase YegS; Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. Bakali, et al. report phosphatidylglycerol kinase activity for the member from Escherichia coli, but refrain from calling that activity synonymous with its biological role. Note that a broader, subfamily-type model (TIGR00147), includes this family but also multiple paralogs in some species and varied functions. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 163414 Cd Length: 293 Bit Score: 478.45 E-value: 2.26e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 6 ASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDDI 85
Cdd:TIGR03702 1 KALLILNGKQADNEDVREAVGDLRDEGIQLHVRVTWEKGDAQRYVAEALALGVSTVIAGGGDGTLREVATALAQIRDDAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 86 PALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYI 165
Cdd:TIGR03702 81 PALGLLPLGTANDFATAAGIPLEPAKALKLALNGAAQPIDLARVNGKHYFLNMATGGFGTRVTTETSEKLKKALGGAAYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 166 IHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDN 245
Cdd:TIGR03702 161 ITGLTRFSELTAASCEFRGPDFHWEGDFLALGIGNGRQAGGGQVLCPDALINDGLLDVRILPAPELLPATLSTLFGGDKN 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 446730053 246 PNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLL 298
Cdd:TIGR03702 241 PEFVRARLPWLEIEAPQPLTFNLDGEPLSGRHFRIEVLPGALRCHLPPGCPLL 293
|
|
| TIGR00147 |
TIGR00147 |
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ... |
1-291 |
7.16e-158 |
|
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 161732 [Multi-domain] Cd Length: 293 Bit Score: 441.94 E-value: 7.16e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 1 MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQC 80
Cdd:TIGR00147 1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 81 egDDIPALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALG 160
Cdd:TIGR00147 81 --DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYCFINMAGGGFGTEITTETPEKLKAALG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 161 GVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLK 240
Cdd:TIGR00147 159 SLSYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLM 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446730053 241 SDE----DNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRL 291
Cdd:TIGR00147 239 SDEgkhtDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
|
|
| LCB5 |
COG1597 |
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ... |
8-294 |
3.67e-82 |
|
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];
Pssm-ID: 441205 [Multi-domain] Cd Length: 295 Bit Score: 249.77 E-value: 3.67e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILN---GKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEgdd 84
Cdd:COG1597 6 LLIVNpasGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTG--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 85 iPALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQtCFINMATGGFGTRITTETPEKLKAALGGVSY 164
Cdd:COG1597 83 -PPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGR-YFLNVAGIGFDAEVVERANRALKRRLGKLAY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 165 IIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEI--LPALVSTLKSD 242
Cdd:COG1597 161 VLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRlrLLRLLPRLLRG 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446730053 243 E--DNPNIIEGASSWFDIQAPHEITFNLDGEPL-SGQNFHIEILPAALRCRLPPD 294
Cdd:COG1597 241 RhlRHPGVRYFRAREVEIESDRPLPVQLDGEPLgLATPLEFEVLPGALRVLVPAD 295
|
|
| PRK13337 |
PRK13337 |
putative lipid kinase; Reviewed |
18-283 |
3.22e-43 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183982 [Multi-domain] Cd Length: 304 Bit Score: 149.81 E-value: 3.22e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 18 NLPlrEAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALiqCEGDDIPALGILPLGTAN 97
Cdd:PRK13337 20 NLP--DVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGI--AEKENRPKLGIIPVGTTN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 98 DFATSVGIPEALDKALKLAIVGNAIAIDMAQVNkQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQP 177
Cdd:PRK13337 96 DFARALHVPRDIEKAADVIIEGHTVPVDIGKAN-NRYFINIAGGGRLTELTYEVPSKLKTMLGQLAYYLKGIEMLPSLKA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 178 DRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPAL-VSTLKSDED---NPNIIEGAS 253
Cdd:PRK13337 175 TDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIhIATLALRGEhikHPKVIYTKA 254
|
250 260 270
....*....|....*....|....*....|....*..
gi 446730053 254 SWFDIQAPHEITFNLDGE-----PLSGQNF--HIEIL 283
Cdd:PRK13337 255 NRIKVSSFDKMQLNLDGEyggklPAEFENLyrHIEVF 291
|
|
| DAGK_cat |
pfam00781 |
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ... |
8-129 |
1.49e-34 |
|
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.
Pssm-ID: 425868 [Multi-domain] Cd Length: 125 Bit Score: 121.92 E-value: 1.49e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILNGKSTDNLP---LREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIqcEGDD 84
Cdd:pfam00781 3 LVIVNPKSGGGKGkklLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLA--GLAT 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446730053 85 IPALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQV 129
Cdd:pfam00781 81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
|
|
| PRK00861 |
PRK00861 |
putative lipid kinase; Reviewed |
23-294 |
1.50e-32 |
|
putative lipid kinase; Reviewed
Pssm-ID: 234850 [Multi-domain] Cd Length: 300 Bit Score: 121.65 E-value: 1.50e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 23 EAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIqceGDDIPaLGILPLGTANDFATS 102
Cdd:PRK00861 23 ALIRAILEPEMDLDIYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALI---GTDIP-LGIIPRGTANAFAAA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 103 VGIPEALDKALKLAIVGNAIAIDMAQVNKQTcFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEI 182
Cdd:PRK00861 99 LGIPDTIEEACRTILQGKTRRVDVAYCNGQP-MILLAGIGFEAETVEEADREAKNRFGILAYILSGLQQLRELESFEVEI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 183 RGENFHWQGDALVIGIGNGRQAGG-GQQLCPNALINDGLLQLRIFTGDEILPALVSTL--------KSDEDNPNIIEGAS 253
Cdd:PRK00861 178 ETEDQIITTNAVAVTVANAAPPTSvLAQGPGAVIPDDGLLDVTIVAPKNLAEAVAASYhllqtalqGNPAERDDIGYLRA 257
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446730053 254 SWFDIQA--PHEITfnLDGEPLSGQNFHIEILPAALRCRLPPD 294
Cdd:PRK00861 258 KQVKITTdpPQKVV--IDGEVVGTTPIEIECLPRSLKVFAPLQ 298
|
|
| PRK13057 |
PRK13057 |
lipid kinase; |
8-294 |
1.93e-32 |
|
lipid kinase;
Pssm-ID: 183857 [Multi-domain] Cd Length: 287 Bit Score: 121.18 E-value: 1.93e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILNGKSTD-NLPLREAIMLLREEGMTIhVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIqceGDDIP 86
Cdd:PRK13057 1 LLLVNRHARSgRAALAAARAALEAAGLEL-VEPPAEDPDDLSEVIEAYADGVDLVIVGGGDGTLNAAAPALV---ETGLP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 87 aLGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQTcFINMATGGFGTRITTETPEKLKAALGGVSYII 166
Cdd:PRK13057 77 -LGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHY-FFNVASLGLSAELARRLTKELKRRWGTLGYAI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 167 HGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQ---LRIFTGDEILPALvstlksde 243
Cdd:PRK13057 155 AALRVLRRSRPFTAEIEHDGRTERVKTLQVAVGNGRYYGGGMTVAHDATIDDGRLDlysLEVAHWWRLLALL-------- 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446730053 244 dnPNIIEGA-SSWFDIQA------------PHEItfNLDGEpLSGQN-FHIEILPAALRCRLPPD 294
Cdd:PRK13057 227 --PALRRGRhGEWPDVRAfrttelelrtrkPRPI--NTDGE-LTTYTpAHFRVLPKALRVLAPPP 286
|
|
| PRK13055 |
PRK13055 |
putative lipid kinase; Reviewed |
37-282 |
5.45e-32 |
|
putative lipid kinase; Reviewed
Pssm-ID: 237282 [Multi-domain] Cd Length: 334 Bit Score: 120.87 E-value: 5.45e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 37 VRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDdiPALGILPLGTANDFATSVGIP-EALDKALKL 115
Cdd:PRK13055 39 FQTTPEPNSAKNEAKRAAEAGFDLIIAAGGDGTINEVVNGIAPLEKR--PKMAIIPAGTTNDYARALKIPrDNPVEAAKV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 116 AIVGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALV 195
Cdd:PRK13055 117 ILKNQTIKMDIGRANEDKYFINIAAGGSLTELTYSVPSQLKSMFGYLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISM 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 196 IGIGNGRQAGGGQQLCPNALINDGLLQLRIF-TGD--EILPALVSTLKSDE--DNPNIIEGASSWFDI--QAPHEITFNL 268
Cdd:PRK13055 197 FFLALTNSVGGFEQIVPDAKLDDGKFTLIIVkTANlfELLHLMALILNGGKhiDDPRVIYIKTSKLTIepLGDDRLMVNL 276
|
250 260
....*....|....*....|.
gi 446730053 269 DGE-----PLSGQNF--HIEI 282
Cdd:PRK13055 277 DGEyggdaPMTFENLkqHIEF 297
|
|
| PRK13059 |
PRK13059 |
putative lipid kinase; Reviewed |
8-282 |
2.67e-30 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183858 Cd Length: 295 Bit Score: 115.52 E-value: 2.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILNGKSTDNLPLRE---AIMLLREEGMTIH-VRVTWEKGDAARY--VEEARKLgvatVIAGGGDGTINEVSTALIQCe 81
Cdd:PRK13059 5 KFIYNPYSGENAIISEldkVIRIHQEKGYLVVpYRISLEYDLKNAFkdIDESYKY----ILIAGGDGTVDNVVNAMKKL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 82 GDDIPaLGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNKQTcFINMATGGFGTRITTETPEKLKAALGG 161
Cdd:PRK13059 80 NIDLP-IGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDKY-FINVASTGLFTDVSQKTDVNLKNTIGK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 162 VSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAgGGQQLCPNALINDGLLQLRIFTG---DEILPALVST 238
Cdd:PRK13059 158 LAYYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTA-GNFNLAYKAEVDDGLLDVIIIKAcpiIDLIPLFIKV 236
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446730053 239 LKSD--EDNPNIIEGASSWFDIQAPHEITFNLDGEplSGQNFHIEI 282
Cdd:PRK13059 237 LKGEhlEDVNGLIYFKTDKLEIESNEEIVTDIDGE--RGPDFPLNI 280
|
|
| DAGKc |
smart00046 |
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ... |
8-131 |
7.92e-27 |
|
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Pssm-ID: 214487 [Multi-domain] Cd Length: 124 Bit Score: 101.60 E-value: 7.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 8 LLILNGKSTDNLPLReAIMLLREEGMTIHVRVTWEKGDAARYVEeARKLGVA-TVIAGGGDGTINEVSTALIQCEGD-DI 85
Cdd:smart00046 1 LVFVNPKSGGGKGEK-LLRKFRLLLNPRQVFDLTKKGPAVALVI-FRDVPDFnRVLVCGGDGTVGWVLNALDKRELPlPE 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446730053 86 PALGILPLGTANDFATSVGIPEALDKALKLAIVGNAIAIDMAQVNK 131
Cdd:smart00046 79 PPVAVLPLGTGNDLARSLGWGGGYDGEKLLKTLRDALESDTVKLDR 124
|
|
| PRK12361 |
PRK12361 |
hypothetical protein; Provisional |
33-293 |
7.39e-17 |
|
hypothetical protein; Provisional
Pssm-ID: 183473 [Multi-domain] Cd Length: 547 Bit Score: 80.43 E-value: 7.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 33 MTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTINEVSTALIqceGDDIpALGILPLGTANDFA------TSVGIP 106
Cdd:PRK12361 273 FDLTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELV---NTDI-TLGIIPLGTANALShalfglGSKLIP 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 107 eaLDKALKLAIVGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKlKAALGGVSYiIHGLMR---MDTLQPDRCEIR 183
Cdd:PRK12361 349 --VEQACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRER-KNALGQLAY-LDGLWRavnENETLTLTVTLD 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 184 G-ENFHWQGDALVigIGNGRQA------GGGQqlcPNalINDGLLQL-----RIFTGDEILP----ALVSTLKSDEDNpN 247
Cdd:PRK12361 425 DaEPQTISTHSLV--VANAAPFtsllaqGGGE---PN--MTDGLLDItwldsGGEPGEQLLSlaelALSGLGKEPEAN-K 496
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446730053 248 IIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPP 293
Cdd:PRK12361 497 VHHAHAKKVTISSQKPIKYVIDGELFEDEDLTIEVQPASLKVFVPY 542
|
|
| PRK11914 |
PRK11914 |
diacylglycerol kinase; Reviewed |
22-223 |
1.01e-14 |
|
diacylglycerol kinase; Reviewed
Pssm-ID: 237021 [Multi-domain] Cd Length: 306 Bit Score: 72.90 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 22 REAIMLLREEGMTIHVRVTWEKGDAARYVEEARKLGVATVIAGGGDGTInevSTALIQCEGDDIPaLGILPLGTANDFAT 101
Cdd:PRK11914 29 ERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVI---SNALQVLAGTDIP-LGIIPAGTGNDHAR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 102 SVGIPEALDKALKLAIV-GNAIAIDMAQVN----KQTCFINMATGGFGTRITTETpEKLKAALGGVSYIIHGLMRMDTLQ 176
Cdd:PRK11914 105 EFGIPTGDPEAAADVIVdGWTETVDLGRIQdddgIVKWFGTVAATGFDSLVTDRA-NRMRWPHGRMRYNLAMLAELSKLR 183
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 446730053 177 --PDRCEIRGENfHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQL 223
Cdd:PRK11914 184 plPFRLVLDGTE-EIVTDLTLAAFGNTRSYGGGMLICPNADHTDGLLDI 231
|
|
| YegS_C |
pfam19279 |
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ... |
159-288 |
1.02e-04 |
|
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.
Pssm-ID: 437111 Cd Length: 158 Bit Score: 41.80 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446730053 159 LGGVSYIIHGLMRMDTLQPDRCEIR--GENFHWQGdALVIgIGNGRQAGGGQQLCPNALINDGLLQL------------- 223
Cdd:pfam19279 22 PGALSYPAAALRALATFRPLRYRVTvdGEVREFSA-ALVA-VANSGYYGGGMRIAPDARVDDGLLDVvvieaasrrtllr 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446730053 224 ---RIFTGDEI-LPAlVSTLKSDEdnpniIEgasswfdIQAPHEITFNLDGEPLSGQNFHIEILPAALR 288
Cdd:pfam19279 100 llpKVYDGRHVrLPQ-VEVLRGRE-----VR-------IEADRPLPAGADGEVLGPLPVRVEVLPGALR 155
|
|
| |
