|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
7-383 |
2.22e-113 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 336.50 E-value: 2.22e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 7 NPLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGL 86
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 87 GLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAF 166
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 167 LYWGIIVLLLVLIGSFFLREAIVSNAVTETLHN---------DYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIG 237
Cdd:cd17353 161 LILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLannaensprDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 238 VQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGN 317
Cdd:cd17353 241 QEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGG 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446737880 318 ITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL---GGFQPTFIIIGVLSVISFIISILI 383
Cdd:cd17353 321 FALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVlytGGYNAAFIIAAALSLVALALALLL 389
|
|
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
8-379 |
6.32e-75 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 237.73 E-value: 6.32e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 8 PLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLG 87
Cdd:TIGR00890 2 WWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 88 LILSSQVSSLPLLYLLAGVVvGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFL 167
Cdd:TIGR00890 82 FTFYAIADSLAALYLTYGLA-SAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPAAFI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 168 YWGIIVLLLVLIGSFFLREAIVSNAVT--ETLHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLvGLSA 245
Cdd:TIGR00890 161 YMGIIFLLVIVLGAFLIGYPPGQLIKTniEVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSL-GLSD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 246 ATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIP-LNYGIYFACVASVAFCFGGNITIFPAI 324
Cdd:TIGR00890 240 GFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPmLNDVLFLATVALVFFTWGGTISLFPSL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446737880 325 VGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL---GGFQPTFIIIGVLSVISFII 379
Cdd:TIGR00890 320 VSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHAlteIGFEYTFIVTGAFALTSLAL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-384 |
4.19e-62 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 204.73 E-value: 4.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 5 SINPLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVL 84
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 85 GLGLILSSQVSSLPLLyLLAGVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVS 163
Cdd:COG2223 81 GIGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 164 QAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETlHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGL 243
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK-ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 244 SAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPA 323
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446737880 324 IVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL----GGFQPTFIIIGVLSVISFIISILIR 384
Cdd:COG2223 319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldatGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-383 |
2.77e-36 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 136.25 E-value: 2.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 8 PLLIVLGTIIVQ-IGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGL 86
Cdd:cd17355 1 GWVVLAVTFLILiLSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 87 GLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLI-KWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQA 165
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAaWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 166 FLYWGIIVLLLVLIGSFFLR-----EAIVSNAVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMGG----LYLISMVKDI 236
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRrrpadLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVvgliVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 237 GvqlvgLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGG 316
Cdd:cd17355 241 G-----ISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446737880 317 NITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL----GGFQPTFIIIGVLSVISFIISILI 383
Cdd:cd17355 316 TVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLydrtGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
10-384 |
3.15e-32 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 124.97 E-value: 3.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 10 LIVLGTIIVQI-GLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGL 88
Cdd:cd17352 3 VVVFASFLVNFfTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 89 ILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLY 168
Cdd:cd17352 83 LLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 169 WGIIVLLLVLIGSFFlreaivsnavtetlhndytprEMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLvGLSAATA 248
Cdd:cd17352 163 LGGLCLNLCVCGLLL---------------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESDA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 249 ANAVAMIAIFNTVGRIILGTLSDK--IGRMKIVSATFIIIGLSVFtLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVG 326
Cdd:cd17352 221 AFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLL-AFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILA 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446737880 327 DFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL----GGFQPTFIIIGVLSVISFIISILIR 384
Cdd:cd17352 300 DLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLrdytGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
23-382 |
1.23e-26 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 109.81 E-value: 1.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 23 GTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYL 102
Cdd:cd17314 17 GFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 103 LAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSF 182
Cdd:cd17314 97 ACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 183 F-LREAIVSNAVTETLHNDYTPR-EMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNT 260
Cdd:cd17314 177 LgFKEPPDNQARLHVQKKKTQTMgEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSIYGLFNA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 261 VGRIILGTLSD-KIGRMKIVSATFIIIGLSVFTLSFIPLNYGI-YFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNY 338
Cdd:cd17314 257 FGRLLWGIVADfFGGRLSTLSILLTILGLGLCAFLFLLKMTPVgLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLY 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446737880 339 GIVYQGFGFGALAGSFIGAILGGFQPT-FIIIGVLSVISFIISIL 382
Cdd:cd17314 337 GILLFAPAIGSILGPMLGAKFYDRTPSyISAVYIYAVIVFLASAI 381
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-386 |
9.39e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 104.18 E-value: 9.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 9 LLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGL 88
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 89 ILSSQVSSLPLLYLLAgVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFL 167
Cdd:COG2271 90 LLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 168 YWGIIVLLLVLIgsfflreaivsnavtetlhndytpremmrtkQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAAT 247
Cdd:COG2271 169 ILGLPGLLLALL-------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 248 AANAVAMIAIFNTVGRIILGTLSDKIGR-MKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVG 326
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446737880 327 DFFGLKNHSTNYGIVYQ-GFGFGALAGSFIGAIL--GGFQPTFIIIGVLSVISFIISILIRPP 386
Cdd:COG2271 298 ELFPKKARGTASGLVNTfGFLGGALGPLLVGYLLdaTGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-389 |
7.97e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 101.87 E-value: 7.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 8 PLLIVLGTIIVQIGLGT-IYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGL 86
Cdd:COG2807 16 RWLLLLAIVLVALNLRPaITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 87 GLILSSQVSSLPLLYLLAgVVVGYADGTAYITsLSNLIK-WFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQA 165
Cdd:COG2807 96 GLLLRSLAPSVALLLAGT-ALIGAGIAVGNVL-LPGLIKrWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 166 FLYWGIIVLLLVLIGSFFLREAIVSNAVTETlhnDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLvGLSA 245
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPAAAAAAPA---AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 246 ATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGL-SVFTLSFIPLNYGIYFACVASvaFCFGGNITIFPAI 324
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLaGLLGLLLAPGSLPWLWAVLLG--LGQGGLFPLALTL 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 325 VGDFFGLKNH-STNYGIVYQGFGFGALAGSFIGAIL----GGFQPTFIIIGVLSVISFIISILIRPPNVE 389
Cdd:COG2807 328 IGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALhdatGSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
8-375 |
5.37e-21 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 93.47 E-value: 5.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 8 PLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNSVAItFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLG 87
Cdd:cd17354 2 RWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNL-LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 88 -----LILSSQVSSLPLLYL-LAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYInGNLIDNLG 161
Cdd:cd17354 81 ygvlwLVVTGLISDLSFWLMcLCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGSQL-YKALFFHD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 162 VSQAFLYWGIIVLLLVLIGSFFLReaIVSNAVtetlhndytpREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLV 241
Cdd:cd17354 160 SARVFLFLAVLPAVVGLLAWFSVR--IVSIEE----------GEFLKDIDFWLLFISLFLGVGPGEMFINNLGQIGQSLT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 242 GLSAATAANAvaMIAIFNTVGRIILGTLSD------KIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFAcVASVAFCFG 315
Cdd:cd17354 228 GPSNTSTLVS--LFSIFSFLGRLLSGLLSDlfvrkfRLPRPSRMVLLLLILSLGHLLQAFGLPSGALYVA-SALIGFGYG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446737880 316 GNITIFPAIVGDFFGLKNHSTNYGIVYQG-----FGFGALAGSFIGAILGG--------------FQPTFIIIGVLSVI 375
Cdd:cd17354 305 GLFSIAPTIVSELFGLKNFGTNYGFLMLApaigsLIFSVIYAGVYYDNGGEgagsddlscigphcFSLTFLIMAAVCLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-349 |
6.77e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 90.03 E-value: 6.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 1 MKQTSINPLLIVLGTIIVQIGLGT-IYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIAT 79
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLgIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 80 AGIVLGLGLILSSQVSSLPLLyLLAGVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLID 158
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLL-LAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 159 NLGVSQAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETLhndyTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGV 238
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG----SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 239 QLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPlNYGIYFACVASVAFCFGGNI 318
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLF 314
|
330 340 350
....*....|....*....|....*....|.
gi 446737880 319 TIFPAIVGDFFGLKNHSTNYGIVYQGFGFGA 349
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-353 |
4.52e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 81.70 E-value: 4.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 20 IGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPL 99
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 100 LyLLAGVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVL 178
Cdd:pfam07690 88 L-LVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 179 IGSFFLREA--IVSNAVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLvGLSAATAANAVAMIA 256
Cdd:pfam07690 167 LLLLPRPPPesKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 257 IFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPL--NYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNH 334
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
330
....*....|....*....
gi 446737880 335 STNYGIVYQGFGFGALAGS 353
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-386 |
3.79e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.27 E-value: 3.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 1 MKQTSINPLLIVLGTIIVQIGLGTIyTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATA 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATA-LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 81 GIVLGLGLILSSQVSSLPLLyLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLID-N 159
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLL-LLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 160 LGVSQAFLYWGI-IVLLLVLIGSFFLREAIVSNAVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGV 238
Cdd:COG0738 159 LSLSWHLPYLILaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 239 QLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPlNYGIYFACVASVAFCFGGni 318
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP-GPWLALIGLALVGLGLSL-- 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446737880 319 tIFPAI---VGDFFGlKNHSTNYGIVYQGFGFGALAGSFIGAILG---GFQPTFIIIGVLSVISFIISILIRPP 386
Cdd:COG0738 316 -MFPTIfslALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLAdafGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
46-384 |
8.30e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.14 E-value: 8.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 46 VAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYL---LAGVVVGYAD--GTAYITSL 120
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLarfLQGLASAAVWpaAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 121 SNlikwfPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETL--H 198
Cdd:cd17325 113 AP-----PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSaaR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 199 NDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKI 278
Cdd:cd17325 188 LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 279 VSATFIIIGLSVFTLSFIPlNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAI 358
Cdd:cd17325 268 ILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346
|
330 340
....*....|....*....|....*....
gi 446737880 359 L---GGFQPTFIIIGVLSVISFIISILIR 384
Cdd:cd17325 347 LydaFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-383 |
4.46e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.74 E-value: 4.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 39 FGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGvVVGYADGTAYIT 118
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF-LLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 119 SLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFLReaivsnavtetl 197
Cdd:cd17319 112 AIKALAEWFPaRERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 198 hndytpremmrtkQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMK 277
Cdd:cd17319 180 -------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 278 IVSATFIIIGLSVFTLSFIPLNYGIYFA--CVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGS-F 354
Cdd:cd17319 247 RRLVIIIGLLLAAVGLLLAYLTTSPVVAviLLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPlL 326
|
330 340 350
....*....|....*....|....*....|..
gi 446737880 355 IGAIL---GGFQPTFIIIGVLSVISFIISILI 383
Cdd:cd17319 327 IGYLVdatGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
11-362 |
5.63e-10 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 60.48 E-value: 5.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 11 IVLGTIIVQIGL--GTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGL 88
Cdd:cd17423 3 VVVLAAFLQNALvfGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 89 ILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLY 168
Cdd:cd17423 83 LLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 169 WGIIVLLLVLIGSfFLREAIVSNAVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVK-DIGVQLVGLSAAT 247
Cdd:cd17423 163 LSALSLHLVPCGA-LLRPLALPGDPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHlVAHARALGLGEYQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 248 AANAVAMIAIFNTVGRIILGTLSDkIGRMKIVSATFIIIGLSVFTLSFIPL--NYGIYFACVASVAFCFGGNITIFPAIV 325
Cdd:cd17423 242 AAFVVSVAAVADAVGRLFSGWLAD-LGPLRLLHLLVLWTALTGLSLLLLPLakVYGSLLALAVAYGFCAGALAPLVFSVL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446737880 326 GDFFGLKNhstnygiVYQGFGFGAL---AGSFIGAILGGF 362
Cdd:cd17423 321 PELVGVER-------VLNATGLLQMiesVGGLLGPPLSGW 353
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-381 |
7.80e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.13 E-value: 7.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 39 FGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLyLLAGVVVGYADGTAYIT 118
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLL-LLGRFLLGLGSGLIDPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 119 SLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVS-QAFLYWGIIVLLLVLIGSFFLREAIVSNAVTET 196
Cdd:cd06174 105 VLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwRAVFLIAAALALLAAILLLLVVPDPPESARAKN 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 197 LHNDYTP-----REMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSD 271
Cdd:cd06174 185 EEASSKSvlkllKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 272 KIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQ----GFGF 347
Cdd:cd06174 265 RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTfgflGGAI 344
|
330 340 350
....*....|....*....|....*....|....
gi 446737880 348 GALAGSFIGAILGGFQPTFIIIGVLSVISFIISI 381
Cdd:cd06174 345 GPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
72-385 |
9.89e-10 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 59.46 E-value: 9.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 72 GLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRY 151
Cdd:cd17429 66 GCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 152 INGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFlreaivsnavtetlhndytpREMMRTKQVYLLFFMLFTSCMGGLYLIS 231
Cdd:cd17429 146 LLKYLCAEFGWRNAMFIQGAVSLNLCVCGALM--------------------RLFTNKVFVAFIFWALFAYCSFVIPFIH 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 232 MVKDigVQLVGLSAATAAN-AVAMIAIFNTVGRIILGTLSDK--IGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACvA 308
Cdd:cd17429 206 LPEI--VKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLpcISVWNVFILANFTLGVCILILPLMHTYTGLAIVC-A 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 309 SVAFcFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAG----SFIGAILGGFQPTFIIIGVLSVISfIISILIR 384
Cdd:cd17429 283 LIGF-SSGYFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGppfaGWIYDITQKYDFSFYVCGLLYMVG-IICLLLK 360
|
.
gi 446737880 385 P 385
Cdd:cd17429 361 P 361
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
41-386 |
4.38e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.60 E-value: 4.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 41 WNLNSVAIT--FSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILS---SQVSSLPLLYLLAGVVVGYADGTA 115
Cdd:cd17365 29 WGLSPAQLGpvGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTafaQSVLQLALLRFLTGLGLGAAMPNA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 116 yITSLSNLIKwfPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIgsfflreaivsnavte 195
Cdd:cd17365 109 -ITLVSEYAP--ARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL---------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 196 tlhndytpreMMRTKQVYLLFFMlftsCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGR 275
Cdd:cd17365 170 ----------LRGTLLLWVTFFM----GLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 276 MKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVyQGFG-FGALAGSF 354
Cdd:cd17365 236 KRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWA-LGVGrLGAILGPL 314
|
330 340 350
....*....|....*....|....*....|....*.
gi 446737880 355 IGAIL----GGFQPTFIIIGVLSVISFIISILIRPP 386
Cdd:cd17365 315 LGGLLlaagLGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-393 |
1.15e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 208 RTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLvGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIG 287
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 288 LSVFTLSFIPlNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAILG---GFQP 364
Cdd:COG2814 87 LGSLLCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdlfGWRW 165
|
170 180
....*....|....*....|....*....
gi 446737880 365 TFIIIGVLSVISFIISILIRPPNVEKKKE 393
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAARA 194
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
71-352 |
1.45e-08 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 55.98 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 71 LGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFR 150
Cdd:cd17428 65 FGARPVTIFSGFMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 151 YINGNLIDNLGVSQAFLYWGIIVLLLVLIGSfflreaivsnavtetlhndytPREMMRTKQVYLLFFMLFTSCMGGLYLI 230
Cdd:cd17428 145 ALQRELIELYGLDGCLLIVGALALNLLACGS---------------------LMRLFKNRVFSALFIAILLFDIGAFPPS 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 231 SMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDK--IGRMKIVSATFIIIGLSVFTLSFIPLNYGIyfACVA 308
Cdd:cd17428 204 LLMEDVARSENIIEEIALIPLVSIIGITTAIGKLILGVLADFkwVNSLYLYVLTLIGMGAALLAIPFAKSYLTL--AVLS 281
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 446737880 309 SVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAG 352
Cdd:cd17428 282 AILGFLSGNWSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLG 325
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
77-342 |
2.17e-08 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 55.59 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 77 IATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNL 156
Cdd:cd17424 71 IILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 157 IDNLGVSQAFLYWGIIVLLLVLIGS---FFLREAIVSNAVTetlhndytpremmrtkqvylLFFMLFTSCMGGLYLISMV 233
Cdd:cd17424 151 IEQFSWRGALLILGGFVLNLCVCGAlmrFLLMPDFLVLAVS--------------------VLFLAYGCSPPFVYLVPYA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 234 KDIGVqlvglSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFII-IGLSVFTLSFIPLNYGiyFACVASVAF 312
Cdd:cd17424 211 LSVGV-----SHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFaVGMDGLCCLFLPILKT--FPLLVPFSF 283
|
250 260 270
....*....|....*....|....*....|....
gi 446737880 313 CF----GGNITIFPAIVGDFFGLKNHSTNYGIVY 342
Cdd:cd17424 284 TFgyfdGAYVALIPVVTSDVVGTSSLSSALGVVY 317
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
25-315 |
2.76e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 55.32 E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 25 IYTWSLFnqpLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLyLLA 104
Cdd:cd17475 15 IPALAPF---LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL-LVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 105 GVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVSA----YGMGSLIFRYINGnlidNLGVSQAFLYWGIIVLLLVLI 179
Cdd:cd17475 91 LFLVGAGYGSVQPGGGRAIMRWFPpRERGLAMGIRQTGvplgGALAAALLPPLAL----HYGWRAAFVVAGLVSILAAVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 180 GSFFLREAIVSNAVTE-TLHNDYTPREMMRTKQVYLLFFMLFTSCMGGL----YLISMVKDIgvqlVGLSAATAANAVAM 254
Cdd:cd17475 167 FWLFYREPPAASAATEsASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFalltFLLLFLHDH----LGLSVVAAGALLAV 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446737880 255 IAIFNTVGRIILGTLSDKIG---RMKIVSATFIIIGLSVFTLSFIPLnyGIYFACVASVAFCFG 315
Cdd:cd17475 243 AQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSP--GTPLWLLVLLLILLG 304
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
39-382 |
1.12e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 39 FGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLaGVVVGYADGTAYIT 118
Cdd:cd17333 26 FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVL-MFLAGLGAGILDTG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 119 SLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDN-LGVSQAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETL 197
Cdd:cd17333 105 ANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 198 HNDYTPREMMRTKQVYLLFFMLFTSC-MGGLY-LISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGR 275
Cdd:cd17333 185 VGAFSASASRLLRNPSIILGALALFLyVGAETaFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKP 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 276 MKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGgnitIFPAIVGDF--FGLKNHSTNYGIVYQGFGFGALAGS 353
Cdd:cd17333 265 HTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAA----LFPTILSLGisNLPYAKGKGTSVLLAAGSIGGAIIP 340
|
330 340 350
....*....|....*....|....*....|..
gi 446737880 354 FIGAIL---GGFQPTFIIIGVLSVISFIISIL 382
Cdd:cd17333 341 FIMGFIaeaVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-393 |
1.44e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.81 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 215 LFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLS 294
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 295 FIPlNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL---GGFQPTFIIIGV 371
Cdd:pfam07690 81 FAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLaslFGWRAAFLILAI 159
|
170 180
....*....|....*....|..
gi 446737880 372 LSVISFIISILIRPPNVEKKKE 393
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPK 181
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
138-383 |
1.95e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 138 SVSAYGMGSLIFRYINGNLIDnlGVSQAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETLHNDYtpREMMRTKQVYLLFF 217
Cdd:COG2211 160 GLLASVLPPPLVAAFGGDAAL--GYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESL--KALLKNRPFLLLLL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 218 MLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFI- 296
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLg 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 297 PLNYGIYFACVASVAFCFGGNITIFPAIVGD---FFGLKNHSTNYGIVYQGFGF-----GALAGSFIGAILG--GFQPT- 365
Cdd:COG2211 316 PGNLWLLLVLAALAGIGLGAILVLPWAMLADvvdYDEWKTGRRREGLYFGIFTFaiklgQALAGALAGLLLAlfGYVAGa 395
|
250 260
....*....|....*....|....*...
gi 446737880 366 ----------FIIIGVLSVISFIISILI 383
Cdd:COG2211 396 aqspsaltgiRLLFFLLPAVLLLLAALL 423
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
215-392 |
4.43e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.42 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 215 LFFMLFTSCMGgLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKivsatFIIIGLSVFTLS 294
Cdd:cd17325 1 LSLALFLDMLG-YGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR-----LLLLGLLLLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 295 FIPLNYGIYFACVASVAFCFG----GNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL---GGFQPTFI 367
Cdd:cd17325 75 TLLFAFATSYWQLLLARFLQGlasaAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLadaLGYRAPFL 154
|
170 180
....*....|....*....|....*
gi 446737880 368 IIGVLSVISFIISILIRPPNVEKKK 392
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPPPN 179
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
23-359 |
5.48e-07 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 51.29 E-value: 5.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 23 GTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYL 102
Cdd:cd17422 17 GVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 103 LAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSF 182
Cdd:cd17422 97 TIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGALQLNIVVCGAL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 183 FlreaivsnavtetlhndytpREMMRTKQVYLLFFMLFTSC---MGGLYLISMVKDIgvqlvGLSAATAANAVAMIAIFN 259
Cdd:cd17422 177 L--------------------RVLKEPGFICYALFGLFATLgffAPQLYIIPLSLSL-----GIDQDWAAYMLSAMAIAE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 260 TVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFiPLNYGIYFACVASVAFCFG-GNI--TIFPAIV-GDFFGLKNHS 335
Cdd:cd17422 232 LFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLF-PFAYGFWSLLVCSIFYGFMfGTVagTHIPLLAeDDVVGIEKMS 310
|
330 340
....*....|....*....|....
gi 446737880 336 TNYGIVYQGFGFGALAGSFIGAIL 359
Cdd:cd17422 311 SALGVYVFIQSIAGLAGPPLGGVL 334
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
238-379 |
1.93e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.46 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 238 VQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFcFGGN 317
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLY-MGAQ 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446737880 318 ITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFI-GAILGGFQP--TFIIIGVLSVISFII 379
Cdd:cd17370 305 ESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIaGYLWDLISPsaAFLFSAVLALIALLL 369
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
35-381 |
2.93e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 2.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 35 LVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVV-VGYA-- 111
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAgIGSAaf 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 112 --DGTAYITSLSnlikwfPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGvSQAFLYWGIIVLLLVLIGSFFLREAIV 189
Cdd:cd17478 102 hpEGARLASQAA------GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-GLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 190 SNAVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMgglYLISMVKDIGVQLV--GLSAATAANAVAMIAIFNTVGRIILG 267
Cdd:cd17478 175 PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSW---VLSSLTTFLPFYLVqrGYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 268 TLSDKIGRMKIVSATfiIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVGDFFGlKNHSTNYGIVYQ-GFG 346
Cdd:cd17478 252 PLSDRFGRRRVIIAS--LLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGlSFG 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 446737880 347 FGALAGSFIGAI--LGGFQPTFIIIGVLSVISFIISI 381
Cdd:cd17478 329 LGGIGAPVLGALadAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
35-381 |
4.29e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 4.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 35 LVSKFGWNLNS--VAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSlPLLYLLAGVVVGYAD 112
Cdd:cd17316 25 LAAEFSLGLSLlqTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT-PILLLVLRFLQGIGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 113 GTAYITSLSNLI-KWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGsFFLREAIVsn 191
Cdd:cd17316 104 GGEYPGASTYVAeFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLA-LLLRRRTL-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 192 avtetlhndytpremmrtkqvyLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSD 271
Cdd:cd17316 181 ----------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 272 KIGRMKIVSATFIIIGLSVFTLSFIPLNYGIY-FACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQ----GFG 346
Cdd:cd17316 239 RIGRKKTLVIGLILSGILALPLFYLLSGSPTLlLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNlgrlGGG 318
|
330 340 350
....*....|....*....|....*....|....*
gi 446737880 347 FGALAGSFIGAILGGFQPTFIIIGVLSVISFIISI 381
Cdd:cd17316 319 GAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
59-180 |
6.59e-06 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 47.91 E-value: 6.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 59 FSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGIS 138
Cdd:cd17420 58 FCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFV 137
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 446737880 139 VSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIG 180
Cdd:cd17420 138 TAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCS 179
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
41-362 |
8.76e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 47.35 E-value: 8.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 41 WNLNSVAITF--SITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLG---LGLILSSQVSSLPLLYLLAGVVVG--YADG 113
Cdd:TIGR00895 47 WGLDPVQLGFlfSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSvftLLCALATNVTQLLILRFLAGLGLGglMPNL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 114 TAYITSLsnlikWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFLREAI----- 188
Cdd:TIGR00895 127 NALVSEY-----APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIdflvs 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 189 --------VSNAVTETLHNDYT---PREMMRTKQVYLLFFMLFTSCMG----GLYLISMVKDIGVQLVGL--------SA 245
Cdd:TIGR00895 202 krpetvrrIVNAIAPQMQAEAQsalPEQKSTQGTKRSVFKALFQGKTAritvLLWLLYFMLLVGVYFLTNwlpklmveLG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 246 ATAANAVAMIAIFNT---VGRIILGTLSDKIGRmKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFP 322
Cdd:TIGR00895 282 FSLSLAATGGALFNFggvIGSIIFGWLADRLGP-RVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLY 360
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446737880 323 AIVGDFFGLKNHSTNYGIvyqGFGFGALaGSFIGAILGGF 362
Cdd:TIGR00895 361 ALMALFYPTAIRATGVGW---AIGIGRL-GAIIGPILAGY 396
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-381 |
4.56e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 4.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 39 FGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADG----- 113
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGfwaia 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 114 TAYITSLSNlikwfPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFLREAIVSNAV 193
Cdd:cd17324 109 AAYAADLVP-----PEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 194 teTLHNDYTPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKI 273
Cdd:cd17324 184 --SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 274 GRMKIVSATFIIIGLSVFtlsFIPLNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGF-GALAG 352
Cdd:cd17324 262 GRRALLIALLLLAAALLL---LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNlGGALG 338
|
330 340 350
....*....|....*....|....*....|..
gi 446737880 353 SFIGAIL---GGFQPTFIIIGVLSVISFIISI 381
Cdd:cd17324 339 AALGGLVldhGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
34-384 |
7.21e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 34 PLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLY---LLAGVVVGY 110
Cdd:cd17489 21 LYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLvlrLIHGIGWGA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 111 AdGTAYITSLSNLIKwfPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYwGIIVLLLVLIGSFFLREAIVS 190
Cdd:cd17489 101 F-TTAAATLVADIIP--PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-AAVLALLALLLVFLVKDPPPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 191 NAVTETLHNDYTPREMMRTKQVYLLFFMLFTSCMGGL--YLISMVKDIGVQLVGLSAATAanavamiAIFNTVGRIILGT 268
Cdd:cd17489 177 AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIstFLPLYAAERGISNAGLFFTVY-------AIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 269 LSDKIGRMKIVSATFIIIGLSVFTLSFIPLNYGIyfacVASVAFCFGGNITIFPAI---VGDFFGLKNHSTNYGIVYQGF 345
Cdd:cd17489 250 LSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWML----LLAAVLYGLGFGLLFPALqalAVDLVPPHRRGAANGTFFIFF 325
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446737880 346 GFGALAGSFIGAIL---GGFQPTFIIIGVLSVISFIISILIR 384
Cdd:cd17489 326 DLGIGLGGLLLGLVaelFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
39-379 |
9.22e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 44.35 E-value: 9.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 39 FGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIatagivlGLGLILSSQVSSLP--------LLYLLAGVVVGY 110
Cdd:TIGR00894 71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSI-------GIGMFLSSVISIVIpwaagggiALVVFCRVIQGL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 111 ADGTAYITSLSNLIKWF-PNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLY----WGIIVLLLVLIGSF--- 182
Cdd:TIGR00894 144 AQGSVSPATHKIIVKWApPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYvfgiVGCAWSLLWFVFPAddp 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 183 --------FLREAIVSNAVTETLHNDY-TP-REMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAV 252
Cdd:TIGR00894 224 sihpciskFEKKYINSSLQGQKGSTRQsLPiKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLS 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 253 AMIAIFNTVGRIILGTLSDKI---GRMKIVSATFII-----IGLSVFTLSFIPLNYGIYFACV------ASVAFCFGGNI 318
Cdd:TIGR00894 304 SLPYLFAWLCSIFAGYLADFLkssKTLSLTAARKIFngiggLGPGIFAYALPYLSAAFYLTIIiltlanAVSSGPLAGVL 383
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446737880 319 TIFPAIVGDFFGLKNHSTNygivYQGFGFGALAGSFIGAIL-----GGFQPTFII---IGVLSVISFII 379
Cdd:TIGR00894 384 INSLDLAPRFLGFIKGITG----LPGFIGGLIASTLAGNILsqdskNVWLIVFLImafVNILCVIFYLI 448
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
256-386 |
9.97e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.15 E-value: 9.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 256 AIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPlNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHS 335
Cdd:cd17328 44 IISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP-NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446737880 336 TNYGIVYQGF----GFGALAGSFIGAILGGFQPTFIIIGVLSVISFIISILIRPP 386
Cdd:cd17328 123 RALGVFYFAIplgsGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVRE 177
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
71-180 |
1.53e-04 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 43.63 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 71 LGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAYGMGSLIFR 150
Cdd:cd17464 70 FGCRKTATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLP 149
|
90 100 110
....*....|....*....|....*....|
gi 446737880 151 YINGNLIDNLGVSQAFLYWGIIVLLLVLIG 180
Cdd:cd17464 150 FLLRVLLDSVGLFNTLRVLCIFMFVLFLAG 179
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
7-184 |
1.91e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 7 NPLLIVLGTI-IVQIGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLG 85
Cdd:cd17490 193 DKKLLFFSLLaILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 86 LGLILSSQVSSLPLLYLLAgVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQ 164
Cdd:cd17490 273 AYCFLIPFAPNLTLLYLLQ-ALNGFGTGILFPLLMSLSIEGVPaEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT 351
|
170 180
....*....|....*....|
gi 446737880 165 AFLYWGIIVLLLVLIGSFFL 184
Cdd:cd17490 352 GFFVIGVIALLAAILSLAYY 371
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
63-383 |
4.06e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 42.22 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 63 FAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGTAYITSLSNLIKWFPNRKGLISGISVSAY 142
Cdd:PRK12307 72 LFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGF 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 143 GMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLI---------------GSFFLREAIVSNAVTETLHNDYTPREMM 207
Cdd:PRK12307 152 GIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIrarapeskeweeaklSGKGKHSQSAWSVFSLSMKGLFNRAQFP 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 208 RTKQVYLLFFMLFTSC--MGGLyLISMVKDIGVQLVGLSAATAanavamIAIFNTV-GRIILGTLSDKIGRMKIVSATFI 284
Cdd:PRK12307 232 LTLCVFIVLFSIFGANwpIFGL-LPTYLAGEGFDTGVVSNLMT------AAAFGTVlGNIVWGLCADRIGLKKTFSIGLL 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 285 IIGLSVFTLSFIPL-NYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQ----GFGFGALAGSFIGAIL 359
Cdd:PRK12307 305 MSFLFIFPLFRIPQdNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNlaatSGTFNSMAATWLGITM 384
|
330 340
....*....|....*....|....*
gi 446737880 360 G-GFQPTFIIIGVLSVISFIISILI 383
Cdd:PRK12307 385 GlGAALTFIVAFWTATILLIIGLSI 409
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
216-400 |
4.08e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 216 FFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSF 295
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 296 IPlNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAIL-----GGFQPTFIIIG 370
Cdd:cd06174 81 AP-SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasslgFGWRAVFLIAA 159
|
170 180 190
....*....|....*....|....*....|
gi 446737880 371 VLSVISFIISILIRPPNVEKKKELKHLHRK 400
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASS 189
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
215-386 |
4.08e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 215 LFFMLFTSCMGGLYLISMVKDIGVQLV--GLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIvsatfIIIGLSVFT 292
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPV-----LLLSLAGSA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 293 LSFIPLNYGIYFACV---ASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAILG---GFQPTF 366
Cdd:cd17330 76 VSYVLLGLSRNLWLLflaRFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStpyGYALPF 155
|
170 180
....*....|....*....|
gi 446737880 367 IIIGVLSVISFIISILIRPP 386
Cdd:cd17330 156 LVAAALALLNLVLVLFFLPP 175
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-187 |
5.20e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 5.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 9 LLIVLGTIIVQIGLGTIYTWslFNQPLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLG--LRKLIATAGIVLGL 86
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTW--LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 87 GLILSSQVSSLPLLYLLAgVVVGYADGTAYITSLSNLIKWFPNRK-GLISGISVSAYGMGSLIFRYINGNLIDNLGVSQA 165
Cdd:COG2271 261 ALLLLALLPSPALAIALL-FLAGFGLGGAFGLLWALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|..
gi 446737880 166 FLYWGIIVLLLVLIGSFFLREA 187
Cdd:COG2271 340 FLLLAALALLAALLALLLLRET 361
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
11-383 |
9.20e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 9.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 11 IVLGTIIVQIGLGTIYTWSLFnqpLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLIL 90
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSL---RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 91 SSQVSSLPLLYLLAgVVVGYADGTAYITSLSNLIKWFPNR-KGLISGISVSAYGMGSLIfryiNGNLIDNLGVSQAFLYW 169
Cdd:cd17477 78 LALTDSPWVWFLLR-FVMGIGLAGLFVVSESWLNALATNEnRGRVLGLYSTVLGLGFAL----GPLLLALVGTAGALPFL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 170 GIIVLLLVligsfflreAIVSNAVTETLHNDYTPREMMRTKQVYLLFFMLFTSC-MGGLYLISMVKDIGVQLV--GLSAA 246
Cdd:cd17477 153 IAAVLLLL---------ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAfVAGFLEGAFYSLLPLYGLrlGLSVA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 247 TAANAVAMIAIFNTVGRIILGTLSDKIGRMK-IVSATFIIIGLSVFTLSFIPLNYGIYFacvasVAFCFGGNI-TIFP-- 322
Cdd:cd17477 224 QAALLLAAFVLGGLLLQWPLGWLADRFDRRRvLLGCALLGALAALLLPLVPGLPLALLV-----LLFLWGGAAgPLYTla 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446737880 323 -AIVGDFFGLKNHSTNYGIVYQGFGFGALAGSFIGAILGGFQPTFIIIGVLSVISFIISILI 383
Cdd:cd17477 299 lALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-384 |
9.50e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 9.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 46 VAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLyLLAGVVVGYADGTAYITSLSNLIK 125
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-LASRALLGIGVAGIMTLATALIGD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 126 WF--PNRKGLIsGISVSAYGMGSLIFRYINGNLIDnLGVSQAFLY--WGIIVLLLVLigsFFLREAivSNAVTETLHNDY 201
Cdd:cd17473 116 YFegEERAKML-GLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVylLALPVLILVL---LFLPEP--ARKSKSAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 202 TPREMMRTKQVYLLFFMLFTSCMGGLYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSA 281
Cdd:cd17473 189 ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 282 TFIIIGLSVFTLSFIPlNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQGFGFG----ALAGSFIGA 357
Cdd:cd17473 269 GFALMALGFLLLALAS-GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGqflsPLVLGPLVN 347
|
330 340
....*....|....*....|....*..
gi 446737880 358 ILGGFQPTFIIIGVLSVISFIISILIR 384
Cdd:cd17473 348 LTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
261-393 |
9.52e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.06 E-value: 9.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 261 VGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPlnyGIYFACVASVAFCFGGNITIFP--AIVGDFFGLKNHSTNY 338
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH---SPWLFAIALVLTGFGGGLFEPAseAMIADVTTPENRTRAF 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446737880 339 GIVYQGFGFGALAGSFIGAILG--GFQPTFIIIGVLSVISFIISILIRPPNVEKKKE 393
Cdd:cd17329 127 SLLYWAINLGVAIGPLLGGLLLlySFRLLFLAAAVLFLLAALVLLFLLPETRPKRRA 183
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-186 |
1.86e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.25 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 35 LVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYADGT 114
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446737880 115 AYITSLSNLIKWFPNRK-GLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFLRE 186
Cdd:COG2223 312 GNGAVFALVPDIFPTKNaGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
71-315 |
1.93e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.93 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 71 LGLRKLIATAGIVLGLGLILSSQVSSLPLLYLLAGVVVGYAdGTAYITSLSNLIKWFP-NRKGLISGISVSAYGMGS--- 146
Cdd:cd17341 61 FGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPkEKIGGAAGGIAGAGNMGVavs 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 147 -----LIFRYINGnLIDNLGVSQAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETLHNDYTPRemMRTKQVYLLFFmLFT 221
Cdd:cd17341 140 qllapLIAGAIVF-DGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAV--LKNYRTWILSL-LYG 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 222 SCMGG-LYLISMVKDIGVQLVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNY 300
Cdd:cd17341 216 VTFGSfVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTS 295
|
250
....*....|....*
gi 446737880 301 GIYFACVASVAFCFG 315
Cdd:cd17341 296 GTNLVLFLALFVALG 310
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
256-392 |
2.62e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.45 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 256 AIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPlNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHS 335
Cdd:cd17324 44 ALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP-SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRG 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 336 TNYGIVYQGFGFGALAGSFIGAILG---GFQPTFIIIGVLSVISFIISILIRPPNVEKKK 392
Cdd:cd17324 123 RAIGLVFSGLTLGLVLGRPLGGLLGqllGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
265-385 |
3.20e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.54 E-value: 3.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 265 ILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACVasVAFCFGGNITIFPAIVGDFFGLKNHSTNYGIVYQG 344
Cdd:cd17388 57 ILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRI--IAGITGATGAVAAAYIADVTPPEQRARNFGLLGAA 134
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446737880 345 FGFGALAGSFIGAILGGFQPT--FIIIGVLSVISFIISILIRP 385
Cdd:cd17388 135 FGLGFIAGPALGGLLGEISPRapFLVAAGLNGLNFLLGLFVLP 177
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
48-380 |
3.62e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 48 ITFSITSFSLSFSTLFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSS---LPLLYLLAGVVVGYADG-TAYITSLSNl 123
Cdd:cd17391 40 LAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNvwqLLILRLLQGVFSGYVPNaTALIASQTP- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 124 ikwfPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFLREaivsNAVTETLHNDYTP 203
Cdd:cd17391 119 ----KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKE----DFKPVEKKKMVST 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 204 REMMRT-KQVYLLFFMLFTSCMGGLYLISM-------VKDIGVQLVGLSAATAANAVAMiAIFNTVGRIILGTLSDKIGR 275
Cdd:cd17391 191 KEVWNSvPNPSLLISLFVTTFIIQLANQSIepiltlyIRQLMGDASNLAFISGLVFSAT-GVSSLLSAPRLGKLGDRIGH 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 276 MKIVSATFIIIGLSVFTLSFI--PLNYGIYFACvasVAFCFGG---------NITIFPAIVGDFFGLknhstNYGIVYQG 344
Cdd:cd17391 270 HRILLGALLASALLYIPQAFVqtPWQLGILRFL---LGLATGGllpainsllAKITPKEVAGRIFGY-----NQSFQYLG 341
|
330 340 350
....*....|....*....|....*....|....*.
gi 446737880 345 FGFGALAGSFIGAILgGFQPTFIIIGVLSVISFIIS 380
Cdd:cd17391 342 NVAGPLLGSAIAAHF-GYRAVFVVTALLVLLNAIWS 376
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
34-385 |
3.70e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.21 E-value: 3.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 34 PLVSKFGWNLNSVAITFSITSFSLSFSTLFAAKLQKKLGlRKLIATAGIVL----GLGLILSSQVSSLPLLYLLAGVVVG 109
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFG-RVRVLVITILLfavfTLLCGFAQNYWQLLILRALAGLGFG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 110 --YADGTAYITSLsnlikWFPNRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVS---QAFLYWGIIVLLLVLIGSFFL 184
Cdd:cd17371 103 geWAAGAALMAEY-----VPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiawRVLFLLGALPALLVLFIRRFV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 185 RE-AIVSNAVTETLHNDYTPREMM----RTKQVYLLFFMLFTSCMGGLYLISM-VKDIGVQLVGLSAATAANAVAMIAIF 258
Cdd:cd17371 178 KEpPQWQAARAARRHFADRPSLRElfspPLLRTTLLASLLATGALGGYYGITTwLPSYLTGERGLSFEGSAGYLVVTILG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 259 NTVGRIILGTLSDKIGRMKIVSATFIIIGLSVFTLSFIPLNYGIYFACVASVAFCFGGNITIFPAIVGDFFGLKNHSTNY 338
Cdd:cd17371 258 GFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQ 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446737880 339 GIVYQ-GFGFGALAGSFIGAIL--GGFQPTFIIIGVLSVISFIISILIRP 385
Cdd:cd17371 338 GFCYNvGRIIGALFPFLVGFLAtsGSLGTAIAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-182 |
4.79e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 4.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 8 PLLIVLGTIIVQIGLGTIYTWSLFNQPLVSKFGWNLNSVAITFSITSFSLSFS-TLFAAKLQKKLGLRKLIATAGIVLGL 86
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 87 GLILSSQVSSLPLLYLLAgVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVSAYGMGSLIFRYINGNLIDNLGVSQA 165
Cdd:cd17330 254 GLLLLPFASSVPLLVLAA-AILAFGTGIVFPALSALLSKSVPsKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVP 332
|
170
....*....|....*..
gi 446737880 166 FLYWGIIVLLLVLIGSF 182
Cdd:cd17330 333 FLLAAGLLLIALFLLSL 349
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
62-384 |
9.05e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.05 E-value: 9.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 62 LFAAKLQKKLGLRKLIATAGIVLGLGLILSSQVSSLPLLyLLAGVVVGYADGTAYITSLSNLIKWFP-NRKGLISGISVS 140
Cdd:cd06180 52 LLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAAL-LALRFLAGAASAFVFVFGSNLVLHHATaAGRGHLIGLLFA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 141 AYGMGSLIF-RYINGNLIDNLGVSQAFLYWGIIVLLLVLIGSFFLREAIVSNAVTETLHND-YTPREMMRTKQVYLLFFm 218
Cdd:cd06180 131 GVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESApGLNRPLWRLALAYGLFG- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 219 lFTSCMGGLYLISMVKDigvqlVGLSAATAANAVAMIAIFNTVGRIILGTLSDKIGRMKIVSATFIIIGLSVftlsFIPL 298
Cdd:cd06180 210 -FGYIITATFLPLIARE-----TGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGV----LLPL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 299 NYGIYFACVASvAFCFGGNITIFPAIV---GDFFGLKNHSTNYGIVYQGFGFGALAG----SFIGAILGGFQPTFIIIGV 371
Cdd:cd06180 280 LSPGPAGLVLS-AVLFGGTFMAITALVmalARELAPPAAPRALALMTASFGVGQILGpllaGWLADATGGFAPALILAAA 358
|
330
....*....|...
gi 446737880 372 LSVISFIISILIR 384
Cdd:cd06180 359 ALVVAALLALLVL 371
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
257-386 |
9.87e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 37.94 E-value: 9.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446737880 257 IFNTVGRIILGTLSDKIGRMKIvsatfIIIGLSVFTLSFIPL----NYGIYFACVASVAFCFGGNITIFPAIVGDFFGLK 332
Cdd:cd17323 45 LGFGLGPLIWAPLSELYGRRPV-----YLVSLFIFVIFQIGCalapNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446737880 333 NHSTNYGIvyqgFGFGALAGSFIGAILGGF-------QPTFIIIGVLSVISFIISILIRPP 386
Cdd:cd17323 120 ERGKAMGV----YSLGPLLGPALGPIIGGFitqslgwRWIFWFLAIISGFCLILIFLFLPI 176
|
|
| |
