|
Name |
Accession |
Description |
Interval |
E-value |
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
3-449 |
1.77e-87 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 274.26 E-value: 1.77e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 3 RLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDT----LPVYFNRMMDVSQD 78
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEdikrLQEKIDDLLVGHSD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 79 ILIihgdSINKIVNRTNVSDDMLNNIPASETISAAG-IYRSIINDTEIDALRINIDEVSP------SLTVTVAKLASARH 151
Cdd:TIGR01386 81 LAL----SILNPDGRLLFERAQGAALVPAVAANDALlELDQADAKMTHYRSILRSVAALPggkgrkPVQITVALDINAHT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 152 NMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVK 231
Cdd:TIGR01386 157 HLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLED 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 232 DFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLS 311
Cdd:TIGR01386 237 AFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 312 LNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHItSFLDTNGYLNIDIASPGT 391
Cdd:TIGR01386 317 LAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITV-RIERRSDEVRVSVSNPGP 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446749510 392 KINEP--EKLFRRFWRGDNSRH--SEGQGLGLSLVKAIAELHGGSATYHYFNKHNVFRITLP 449
Cdd:TIGR01386 396 GIPPEhlSRLFDRFYRVDPARSnsGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
166-449 |
1.07e-47 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 166.62 E-value: 1.07e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 166 IVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAH 245
Cdd:COG0642 40 LLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSH 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 246 ELRTPINALLGQNQVTLSQTRsiAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEY 325
Cdd:COG0642 120 ELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 326 LSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNGYLNIDIASPGTKINEP--EKLF 400
Cdd:COG0642 198 LAEEKGIELELDLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE-GDRVRISVEDTGPGIPPEdlERIF 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446749510 401 RRFWRGDNSRHSEGQGLGLSLVKAIAELHGGSATYHY-FNKHNVFRITLP 449
Cdd:COG0642 277 EPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESePGKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
221-452 |
4.38e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 162.38 E-value: 4.38e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 221 ALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNI-EELENISRLTENILFLARAD 299
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIrESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 300 KNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFL 376
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElplVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446749510 377 DtNGYLNIDIASPGTKINEP--EKLFRRFWRGDNSRHSEGQGLGLSLVKAIAELHGGSATYHY-FNKHNVFRITLPQRN 452
Cdd:COG2205 161 E-GDGVRISVSDNGPGIPEEelERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESePGGGTTFTVTLPLAE 238
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
154-451 |
1.89e-46 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 167.26 E-value: 1.89e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 154 LEQYKiNSIIICIVAIVLCSVLSPLL-IRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKD 232
Cdd:PRK09835 180 INDLK-NKLIMTASVISLLIVFIVLLaVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDV 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 233 FERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSL 312
Cdd:PRK09835 259 FTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDL 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 313 NKEVENLLDYLEYLSDEKEICFKVECNQ-QIFADKILLQRMLSNLIVNAIRYSPEKSRIhITSFLDTNGYLNIDIASPGT 391
Cdd:PRK09835 339 ADEVGKVFDFFEAWAEERGVELRFVGDPcQVAGDPLMLRRAISNLLSNALRYTPAGEAI-TVRCQEVDHQVQLVVENPGT 417
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749510 392 KINEPE--KLFRRFWRGDNSRH--SEGQGLGLSLVKAIAELHGGSATYHYFNKHNVFRITLPQR 451
Cdd:PRK09835 418 PIAPEHlpRLFDRFYRVDPSRQrkGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLPRL 481
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
6.91e-46 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 154.47 E-value: 6.91e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPEKSRIHITSFLDTNgYLNIDIASPGTKINE--PEKLFRRFWRGDNSRHSEGQGLGLSLVKAIA 426
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDD-VVNIMFKNPSSHPLDfkLEKLFERFYRGDNSRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|...
gi 446749510 427 ELHGGSATYHYFNKHNVFRITLP 449
Cdd:cd16923 80 ELHGGSASAEYDDNHDLFKVRLP 102
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
115-449 |
3.79e-42 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 153.55 E-value: 3.79e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 115 IYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVT 194
Cdd:COG5002 44 LLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 195 EALNYNDSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQ-TRSIAEYQK 273
Cdd:COG5002 124 LLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERRE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 274 TIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQ 350
Cdd:COG5002 204 YLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpllVLGDPDRLE 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 351 RMLSNLIVNAIRYSPEKSRIHITSFLDtNGYLNIDIASPGTKINEP--EKLFRRFWRGDNS--RHSEGQGLGLSLVKAIA 426
Cdd:COG5002 284 QVLTNLLDNAIKYTPEGGTITVSLREE-DDQVRISVRDTGIGIPEEdlPRIFERFYRVDKSrsRETGGTGLGLAIVKHIV 362
|
330 340
....*....|....*....|....
gi 446749510 427 ELHGGSATYHY-FNKHNVFRITLP 449
Cdd:COG5002 363 EAHGGRIWVESePGKGTTFTITLP 386
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
141-451 |
3.81e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 110.32 E-value: 3.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 141 VTVAK--------LASARHNMLEQYKINSIIICIVAIVLCSVLSpllirtglREIKKLSGVTEALNYNdsrEPVEVSAL- 211
Cdd:PRK11100 164 LSVGKpnssmapfIKRSERRILWAGALLLGIALLIGAGVVWWLN--------RSIRRLTRYADAVTEG---KPVPLPKLg 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 212 PRELKPLGQALNKMHHALV-KDF-ERLSQfadDLAHELRTPINALLGQNQvtLSQTRSIAEYQKTIAGNIE-ELENISRL 288
Cdd:PRK11100 233 SSELRELAQALESMRVKLEgKAYvEQYVQ---TLTHELKSPLAAIRGAAE--LLQEDPPPEDRARFTGNILtQSARLQQL 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 289 TENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVEC-NQQIFADKILLQRMLSNLIVNAIRYSPEK 367
Cdd:PRK11100 308 IDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPdDARVLGDPFLLRQALGNLLDNAIDFSPEG 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 368 SRIHITSFLDtNGYLNIDIASPGTKINEP--EKLFRRFW---RGDNSRHSegQGLGLSLVKAIAELHGGSATYHyfNKHN 442
Cdd:PRK11100 388 GTITLSAEVD-GEQVALSVEDQGPGIPDYalPRIFERFYslpRPANGRKS--TGLGLAFVREVARLHGGEVTLR--NRPE 462
|
330
....*....|..
gi 446749510 443 ---VFRITLPQR 451
Cdd:PRK11100 463 ggvLATLTLPRH 474
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
108-431 |
9.39e-26 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 109.15 E-value: 9.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 108 ETISAAGIYRSI-INDTEIDALRInidevSPSLTVTvaklASARHNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLRE 186
Cdd:NF012163 121 DPVSDDGTRRPIlVNGQEVGALGA-----SPVERLT----RNTDINFDSQQKRASWLIVALALLLAALAAFLLARGLLAP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 187 IKKLSGVTEALNYNDSREPVEVSAlPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTR 266
Cdd:NF012163 192 VKRLVEATHRLAAGDYTTRVTPTS-NDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIR 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 267 SIAeyQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLS----LNKEVENLLDYLEylSDEKEICFKVECNQQI 342
Cdd:NF012163 271 KFT--PESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDlvplLEVEGGAFRERFA--SAGLELEVSLPDSSLV 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 343 FADKILLQRMLSNLIVNAIRYSPEKSRIHI-TSFLDTNGYLNIDIASPGTKINEPEKLFRRFWRGDNSRH--SEGQGLGL 419
Cdd:NF012163 347 FGDRDRLMQLFNNLLENSLRYTDSGGSLHIsASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNraSGGSGLGL 426
|
330
....*....|..
gi 446749510 420 SLVKAIAELHGG 431
Cdd:NF012163 427 AISLNIVQAHGG 438
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
349-448 |
1.66e-23 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 94.21 E-value: 1.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLnIDIASPGTKINE--PEKLFRRFWRGDNSRHSEGQGLGLSLVKAIA 426
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVV-LEVEDNGPGIPEedLERIFERFYRGDKSREGGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 446749510 427 ELHGGSATYHY-FNKHNVFRITL 448
Cdd:cd00075 80 EAHGGRITVESePGGGTTFTVTL 102
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
178-435 |
7.04e-23 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 100.49 E-value: 7.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 178 LLIRTGL--REIKKLSGVTEALNYN--DSREPVEVSALPRELKPLGQALN----KMHHALVKdfERlsQFADDLAHELRT 249
Cdd:PRK10337 175 LIILMVLlgRELAPLKKLALALRMRdpDSETPLNATGVPSEVRPLVEALNqlfaRTHAMMVR--ER--RFTSDAAHELRS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 250 PINALLGQNQVT-LSQTRSIAEyQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSD 328
Cdd:PRK10337 251 PLAALKVQTEVAqLSDDDPQAR-KKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQ 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 329 EKEICFKVECNqqifADKI-------LLQRMLSNLIVNAIRYSPEKSRIHITSfldTNGYLNIDIASPGTkinEPEKLFR 401
Cdd:PRK10337 330 QAGIDVRLTLN----AHPVirtgqplLLSLLVRNLLDNAIRYSPQGSVVDVTL---NARNFTVRDNGPGV---TPEALAR 399
|
250 260 270
....*....|....*....|....*....|....*..
gi 446749510 402 ---RFWRgDNSRHSEGQGLGLSLVKAIAELHGGSATY 435
Cdd:PRK10337 400 igeRFYR-PPGQEATGSGLGLSIVRRIAKLHGMNVSF 435
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
344-451 |
7.76e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 92.71 E-value: 7.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 344 ADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNGYLNIDIASPGTKINE--PEKLFRRFWRGD-NSRHSEGQGLGLS 420
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERD-GDHVEITVEDNGPGIPPedLEKIFEPFFRTDkRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 446749510 421 LVKAIAELHGGSATYHY-FNKHNVFRITLPQR 451
Cdd:smart00387 80 IVKKLVELHGGEISVESePGGGTTFTITLPLE 111
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
71-452 |
2.43e-22 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 99.47 E-value: 2.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 71 RMMDVSQDILIIHGDSINKIVNRTNVSDDMLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASAR 150
Cdd:COG4251 117 ELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLL 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 151 HNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSALPRELKPLGQALNKMHHALV 230
Cdd:COG4251 197 LLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELE 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 231 KDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRS-----IAEYQKTIAGNIEELeniSRLTENILFLARADKNNVlv 305
Cdd:COG4251 277 RSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDkldeeGREYLERIRDAAERM---QALIDDLLAYSRVGRQEL-- 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 306 KLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKS--RIHITSfLDTNGYLN 383
Cdd:COG4251 352 EFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEppRIEIGA-EREGGEWV 430
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446749510 384 IDIASPGTKINEP--EKLFRRFWRGDNSRHSEGQGLGLSLVKAIAELHGGSATYHY-FNKHNVFRITLPQRN 452
Cdd:COG4251 431 FSVRDNGIGIDPEyaEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESePGEGATFYFTLPKAP 502
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-432 |
1.06e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 89.77 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 339 NQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLNIDIASPGTKINEPEKLFRRFWRGDnSRHSEGQGLG 418
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSD-GQNYGGSGLG 82
|
90
....*....|....
gi 446749510 419 LSLVKAIAELHGGS 432
Cdd:cd16940 83 LSIVKRIVELHGGQ 96
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
209-432 |
2.43e-20 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 92.74 E-value: 2.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 209 SALPRelkpLGQALNKMH---HALVKDFErlsQFADDLAHELRTPINALlgQNQVTLSQTRSIAEyQKTIAGNIEELENi 285
Cdd:PRK10604 189 SSLER----LGVAFNQMAdniNALIASKK---QLIDGIAHELRTPLVRL--RYRLEMSDNLSAAE-SQALNRDIGQLEA- 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 286 srLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEI-CFKVECNQQIFADKILLQRMLSNLIVNAIRYS 364
Cdd:PRK10604 258 --LIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVrLDTPHQGDYGALDMRLMERVLDNLLNNALRYA 335
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 365 PEKSRIHITsFLDTNGYLNIDIASPGTKINEPEKLFRRFWRGDNSRH--SEGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10604 336 HSRVRVSLL-LDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDraTGGCGLGLAIVHSIALAMGGS 404
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
243-449 |
5.67e-20 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 91.56 E-value: 5.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 243 LAHELR---TPI--NALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNnvlvKLDSLSLNKEVE 317
Cdd:COG5000 208 IAHEIKnplTPIqlSAERLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEP----QLEPVDLNELLR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 318 NLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDtNGYLNIDIASPGTKIN 394
Cdd:COG5000 284 EVLALYEPALKEKDIRLELDLDPDlpeVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE-DGRVRIEVSDNGPGIP 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 395 EP--EKLFRRFwrgdNSRHSEGQGLGLSLVKAIAELHGGSATYHyfNKHN---VFRITLP 449
Cdd:COG5000 363 EEvlERIFEPF----FTTKPKGTGLGLAIVKKIVEEHGGTIELE--SRPGggtTFTIRLP 416
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
344-452 |
1.78e-19 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 83.57 E-value: 1.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 344 ADKILLQRMLSNLIVNAIRYSPEKSRIHITsfLDTNGYLNIDIASPGTKINEP--EKLFRRFWRGDnSRHSEGQGLGLSL 421
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT--LSEGGELTLTVEDNGIGIPPEdlPRIFEPFSTAD-KRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 446749510 422 VKAIAELHGGSATYHY-FNKHNVFRITLPQRN 452
Cdd:pfam02518 78 VRKLVELLGGTITVESePGGGTTVTLTLPLAQ 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
201-431 |
2.24e-19 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 89.26 E-value: 2.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 201 DSREPVEVSALPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINA------LLGQNQVTLSQTRsiaeyqkt 274
Cdd:PRK10755 102 DNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGirlhleLLEKQHHIDVAPL-------- 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 275 iagnIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEV----ENLLDYLEYLSDEKEICFKVECNQQIFADKILLQ 350
Cdd:PRK10755 174 ----IARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVilpsQDELSEMLEQRQQTLLLPESAADITVQGDATLLR 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 351 RMLSNLIVNAIRYSPEKSRIHITSFLDTNGY-LNIDIASPG---TKINEPEKLFRRFwrgdNSRHSeGQGLGLSLVKAIA 426
Cdd:PRK10755 250 LLLRNLVENAHRYSPEGSTITIKLSQEDGGAvLAVEDEGPGideSKCGELSKAFVRM----DSRYG-GIGLGLSIVSRIT 324
|
....*
gi 446749510 427 ELHGG 431
Cdd:PRK10755 325 QLHHG 329
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
243-450 |
5.76e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 89.71 E-value: 5.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 243 LAHELRTPINALLGQNQV-TLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLD 321
Cdd:PRK10490 671 LSHDLRTPLTVLFGQAEIlTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQ 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 322 YLEYLSDEKEIcfKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGyLNIDI--ASPGTKINEP 396
Cdd:PRK10490 751 MLEPGLSGHPI--NLSLPEPltlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGER-LQLDVwdNGPGIPPGQE 827
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446749510 397 EKLFRRFWRGDNSRHSEGQGLGLSLVKAIAELHGGsaTYHYFNKHN---VFRITLPQ 450
Cdd:PRK10490 828 QLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGG--TIWAENRPEggaCFRVTLPL 882
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
201-431 |
2.25e-18 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 85.72 E-value: 2.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 201 DSREPVE-VSALPRELK------PLGqalNKMHHALVKDFERLSQ-------FADDLAHELRTPINALLGQNQvTLSQTR 266
Cdd:TIGR02966 68 RFSEPLElPSPINSERVleiriaPYG---EEQKLLVARDVTRLRRleqmrrdFVANVSHELRTPLTVLRGYLE-TLADGP 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 267 SI--AEYQKTIAGNIEELENISRLTENILFLAR-----ADKNNVLVKLDSLslnkeVENLLDYLEYLSDEKE--ICFKVE 337
Cdd:TIGR02966 144 DEdpEEWNRALEIMLEQSQRMQSLVEDLLTLSRlesaaSPLEDEPVDMPAL-----LDHLRDEAEALSQGKNhqITFEID 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 338 CNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGyLNIDIASPGTKInEPE---KLFRRFWRGDNSRHSE- 413
Cdd:TIGR02966 219 GGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGG-AEFSVTDTGIGI-APEhlpRLTERFYRVDKSRSRDt 296
|
250
....*....|....*....
gi 446749510 414 -GQGLGLSLVKAIAELHGG 431
Cdd:TIGR02966 297 gGTGLGLAIVKHVLSRHHA 315
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
127-432 |
3.55e-18 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 86.61 E-value: 3.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 127 ALRINIDEVSPSLTVTVAKLA-SARHNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREP 205
Cdd:PRK10549 131 PILVNGAEVGWVIASPVERLTrNTDINFDKQQRRTSWLIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTR 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 206 VEVSAlPRELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLG-----QNQVTLSQTRSIAEYQKtiagnie 280
Cdd:PRK10549 211 VTPTS-RDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGeleaiQDGVRKFTPESVASLQA------- 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 281 ELENISRLTENILFLARADknnvlvkLDSLSLNKEVENLLDYLE---------YLSDEKEICFKVECNQQIFADKILLQR 351
Cdd:PRK10549 283 EVGTLTKLVDDLHQLSLSD-------EGALAYRKTPVDLVPLLEvaggafrerFASRGLTLQLSLPDSATVFGDPDRLMQ 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 352 MLSNLIVNAIRYSPEKSRIHITSFLDTNGY-LNIDIASPGTKINEPEKLFRRFWRGDNSRH--SEGQGLGLSLVKAIAEL 428
Cdd:PRK10549 356 LFNNLLENSLRYTDSGGSLHISAEQRDKTLrLTFADSAPGVSDEQLQKLFERFYRTEGSRNraSGGSGLGLAICLNIVEA 435
|
....
gi 446749510 429 HGGS 432
Cdd:PRK10549 436 HNGR 439
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
214-451 |
1.08e-17 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 85.08 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 214 ELKPLGQALNKMHHAL------VKDFERLSQ-FADDLAHELRTPINA------LLGQNQVTL-SQTRSIAEYQKTiagni 279
Cdd:NF040691 242 DLARLARSFNQMADSLqrqirqLEELSRLQQrFVSDVSHELRTPLTTirmaadVIHDSRDDFdPATARSAELLHT----- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 280 eELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIF---ADKILLQRMLSNL 356
Cdd:NF040691 317 -ELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVvaeVDPRRVERVLRNL 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 357 IVNAIRYSpEKSRIHITsfLDTNG---YLNIDIASPGTKINEPEKLFRRFWRGDNSR--HSEGQGLGLSLVKAIAELHGG 431
Cdd:NF040691 396 VVNAIEHG-EGKPVVVT--VAQDDtavAVTVRDHGVGLKPGEVALVFDRFWRADPARarTTGGTGLGLAIALEDARLHGG 472
|
250 260
....*....|....*....|....*
gi 446749510 432 -----SATyhyfNKHNVFRITLPQR 451
Cdd:NF040691 473 wleawGRP----GQGSQFRLTLPRV 493
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
243-450 |
3.53e-17 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 82.35 E-value: 3.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 243 LAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGN-IEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLD 321
Cdd:NF012226 145 IAHELRTPITILQGRLQGILD---GVFEPDPALFKSlLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLK 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 322 YLEYLSDEKEICFKVE-CNQQIFADKILLQRMLSNLIVNAIRYSpEKSRIHITSFLDTNGY-LNIDIASPGTKINEPEKL 399
Cdd:NF012226 222 MFEDRLEQAQLTIVLNlTATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWiLQIEDEGPGIAEEYQQDL 300
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 446749510 400 FRRFWRGDNSRHSE--GQGLGLSLVKAIAELHGGSATYHYFNKHNVFRITLPQ 450
Cdd:NF012226 301 FNPFFRLEQSRNKEfgGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTIKLPA 353
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
207-449 |
4.17e-17 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 82.54 E-value: 4.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 207 EVSALPRELKPLGQALNKMHHAlvkdfERLS---QFADDLAHELRTPINALLGQNQV---TLSQTRSIAEYQKTIAGNIE 280
Cdd:COG4191 115 DITELERAEEELRELQEQLVQS-----EKLAalgELAAGIAHEINNPLAAILGNAELlrrRLEDEPDPEELREALERILE 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 281 ELENISRLTENILFLARADKnnvlVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQ---QIFADKILLQRMLSNLI 357
Cdd:COG4191 190 GAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVELDLPPdlpPVLGDPGQLEQVLLNLL 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 358 VNAIRYSPEKS--RIHITSFLDtNGYLNIDIASPGTKINEP--EKLFRRFW----RGdnsrhsEGQGLGLSLVKAIAELH 429
Cdd:COG4191 266 INAIDAMEEGEggRITISTRRE-GDYVVISVRDNGPGIPPEvlERIFEPFFttkpVG------KGTGLGLSISYGIVEKH 338
|
250 260
....*....|....*....|.
gi 446749510 430 GGSATYHY-FNKHNVFRITLP 449
Cdd:COG4191 339 GGRIEVESePGGGTTFTITLP 359
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
234-431 |
7.06e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 76.93 E-value: 7.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 234 ERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIaEYQKTIAGNIEELENISRLTENILFLARADKnnvlVKLDSL 310
Cdd:PRK11360 385 ERLAalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP-PSQEYLSVVLREVDRLNKVIDQLLEFSRPRE----SQWQPV 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 311 SLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLNIDIA 387
Cdd:PRK11360 460 SLNALVEEVLQLFQTAGVQARVDFETELDNElppIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVSIE 539
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446749510 388 SPGTKInEPE---KLFRRFWrgdnSRHSEGQGLGLSLVKAIAELHGG 431
Cdd:PRK11360 540 DNGCGI-DPEllkKIFDPFF----TTKAKGTGLGLALSQRIINAHGG 581
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-432 |
1.30e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 69.80 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 345 DKILLQRMLSNLIVNAIRYSPEKSRIHI-TSFLDTNGYLNIDIASPGTKINEPEKLFRRFWRGDNSRH--SEGQGLGLSL 421
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIrAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNraSGGSGLGLAI 80
|
90
....*....|.
gi 446749510 422 VKAIAELHGGS 432
Cdd:cd16946 81 CHNIALAHGGT 91
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-432 |
2.12e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 68.89 E-value: 2.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPEKsrIHITSFLDTNG-YLNIDIASPGTKINEPEKLFRRFWRGDNSR--HSEGQGLGLSLVKAI 425
Cdd:cd16949 1 LARALENVLRNALRYSPSK--ILLDISQDGDQwTITITDDGPGVPEDQLEQIFLPFYRVDSARdrESGGTGLGLAIAERA 78
|
....*..
gi 446749510 426 AELHGGS 432
Cdd:cd16949 79 IEQHGGK 85
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
212-432 |
4.21e-14 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 73.81 E-value: 4.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 212 PRELKPLGQALNKMHHAL---VKDFERLsqfADDLAHELRTPI------NALLgqnqvtlsqTRSIAEYQKT--IAGNIE 280
Cdd:PRK09470 219 PQEFRQAGASFNQMVTALermMTSQQRL---LSDISHELRTPLtrlqlaTALL---------RRRQGESKELerIETEAQ 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 281 ELEN-ISRLteniLFLARADKNNVLVKlDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNL 356
Cdd:PRK09470 287 RLDSmINDL----LVLSRNQQKNHLER-ETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGpwpINGNPNALASALENI 361
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446749510 357 IVNAIRYSpeKSRIHITSFLDTNG-YLNIDIASPGTKINEPEKLFRRFWRGDNS--RHSEGQGLGLSLVKAIAELHGGS 432
Cdd:PRK09470 362 VRNALRYS--HTKIEVAFSVDKDGlTITVDDDGPGVPEEEREQIFRPFYRVDEArdRESGGTGLGLAIVENAIQQHRGW 438
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
239-451 |
6.40e-14 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 73.12 E-value: 6.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 239 FADdLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNnvlvklDSLSLNKEVE- 317
Cdd:PRK11006 208 FAN-VSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAA------PTIDLNEKVDv 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 318 -NLLDYLEY----LSDEK-EICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNG-YLNIDIASPG 390
Cdd:PRK11006 281 pMMLRVLEReaqtLSQGKhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGaEFSVEDNGPG 360
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446749510 391 TkinEPEKLFR---RFWRGDN--SRHSEGQGLGLSLVKaiaelhggsatyHYFNKHN-------------VFRITLPQR 451
Cdd:PRK11006 361 I---APEHIPRlteRFYRVDKarSRQTGGSGLGLAIVK------------HALSHHDsrleiesevgkgtRFSFVLPER 424
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
243-431 |
1.13e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 72.29 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 243 LAHELRTPINAL--------LGQNQ-VTLSQTRSIAEYQKTIAgniEELENISRLTENILFLARAdKNNVL----VKLDS 309
Cdd:PRK09303 158 LAHDLRTPLTAAslaletleLGQIDeDTELKPALIEQLQDQAR---RQLEEIERLITDLLEVGRT-RWEALrfnpQKLDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 310 LSLNKEVenLLDYLEYLSdEKEICFKVECNQQI---FADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLNIDI 386
Cdd:PRK09303 234 GSLCQEV--ILELEKRWL-AKSLEIQTDIPSDLpsvYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVQVSI 310
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446749510 387 AS--PGTKINEPEKLFRRFWRGDNSRHSEGQGLGLSLVKAIAELHGG 431
Cdd:PRK09303 311 CDtgPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
236-449 |
1.25e-13 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 71.80 E-value: 1.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 236 LSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKnnvlVKLDSLSLNKE 315
Cdd:COG3852 135 VGELAAGLAHEIRNPLTGIRGAAQL-LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 316 VENLLDYLEYLSDeKEICFKVECNQ---QIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTN---------GYLN 383
Cdd:COG3852 210 LERVLELLRAEAP-KNIRIVRDYDPslpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQvtlgglrprLYVR 288
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446749510 384 IDIASPGTKINEP--EKLFRRFWrgdnSRHSEGQGLGLSLVKAIAELHGGSATYH-YFNKHNVFRITLP 449
Cdd:COG3852 289 IEVIDNGPGIPEEilDRIFEPFF----TTKEKGTGLGLAIVQKIVEQHGGTIEVEsEPGKGTTFRIYLP 353
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
1.63e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 66.32 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSpeKSRIHITSFLDTNgYLNIDIASPGTKINEPE--KLFRRFWRGDNSRHSEGQGLGLSLVKAIA 426
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGN-RTRIQVLDNGPGIAPEEvdELFQPFYRGDNARGTSGTGLGLAIVQRIS 77
|
....*...
gi 446749510 427 ELHGGSAT 434
Cdd:cd16950 78 DAHGGSLT 85
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-434 |
2.08e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 66.33 E-value: 2.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 345 DKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNgYLNIDIASPGTKINEP--EKLFRRFWRGDNSRHSEGQ-GLGLSL 421
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEE-YLYFEIWDNGHGFSEQdlKKALELFYRDDTSRRSGGHyGMGLYI 79
|
90
....*....|...
gi 446749510 422 VKAIAELHGGSAT 434
Cdd:cd16975 80 AKNLVEKHGGSLI 92
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
329-432 |
2.16e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 71.48 E-value: 2.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 329 EKEICFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSpeKSRIHITSFLDTN-GYLNIDIASPGTKINEPEKLFRRFWRG 406
Cdd:PRK09467 311 EREIETALqPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKrAWFQVEDDGPGIPPEQLKHLFQPFTRG 388
|
90 100
....*....|....*....|....*.
gi 446749510 407 DNSRHSEGQGLGLSLVKAIAELHGGS 432
Cdd:PRK09467 389 DSARGSSGTGLGLAIVKRIVDQHNGK 414
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
344-436 |
4.19e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 65.59 E-value: 4.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 344 ADKIllQRMLSNLIVNAIRYSPEKSRIH-ITSFLDTNGYL-NIDIASPGTKINEPEKLFRRFWRG--DNSRHSEGQGLGL 419
Cdd:cd16925 2 AEKY--ERVVLNLLSNAFKFTPDGGRIRcILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGL 79
|
90
....*....|....*..
gi 446749510 420 SLVKAIAELHGGSATYH 436
Cdd:cd16925 80 SIVKEFVELHGGTVTVS 96
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
245-431 |
1.10e-11 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 66.70 E-value: 1.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 245 HELRTPinallgqnqvtLSQTRSIAE------YQ-KTIAGNI-----EELENISRLTENILFLARADKNNVLVKLDSLSL 312
Cdd:NF033092 381 HELRTP-----------LTTMRSYLEaladgaWKdPELAPRFlgvtqNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNF 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 313 NKEVENLLDYLEYLSDEKEICFKVEC-NQQIFA----DKIllQRMLSNLIVNAIRYSPEKSRIHItSFLDTNGYLNIDIA 387
Cdd:NF033092 450 NEFFNYIIDRFEMILKNKNITFKREFpKRDLWVeidtDKI--TQVLDNIISNAIKYSPEGGTITF-RLLETHNRIIISIS 526
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 446749510 388 SPGTKI--NEPEKLFRRFWRGDNSRHSE--GQGLGLSLVKAIAELHGG 431
Cdd:NF033092 527 DQGLGIpkKDLDKIFDRFYRVDKARSRKmgGTGLGLAIAKEVVEAHGG 574
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
349-432 |
2.73e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 60.20 E-value: 2.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPE---KSRIHITSFLDTNGYLNIDIASPGTKINEPE--KLFRRFWRGDNS--RHSEGQGLGLSL 421
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEgevTLRVSLEEEEEDGVQLRFSVEDTGIGIPEEQqaRLFEPFSQADSSttRKYGGTGLGLAI 80
|
90
....*....|.
gi 446749510 422 VKAIAELHGGS 432
Cdd:cd16922 81 SKKLVELMGGD 91
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-433 |
3.83e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 59.75 E-value: 3.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPEKSRIhitSFLDTNGYLNIDIAS--PGTKINEPEKLFRRFWRGDNSR--HSEGQGLGLSLVKA 424
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRI---ALLVSGGRLTLIVEDdgPGIPAAARERVFEPFVRLDPSRdrATGGFGLGLAIVHR 77
|
....*....
gi 446749510 425 IAELHGGSA 433
Cdd:cd16939 78 VALWHGGHV 86
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
234-297 |
4.11e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 58.38 E-value: 4.11e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749510 234 ERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLAR 297
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
85-432 |
5.00e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 64.71 E-value: 5.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 85 DSINKIVNRTNVSDDMLNNIPASETisaagiYRSIIN--------DTEIDALRINIDEVSPSLTVTVAK----------- 145
Cdd:COG4192 225 DRLQYLKDELDRNLQALKNYPSTIT------LRQLIDellaigsgEGGLPSLRRDELAAQATLEALAEEnnsileqlrtq 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 146 ----LASARHNM----------LEQYKINSIIICIVAIVLCSVLSPLLIRTGL-REIKKLSGVTEALNYNDSREPV---- 206
Cdd:COG4192 299 isglVGNSREQLvalnqetaqlVQQSGILLLAIALLSLLLAVLINYFYVRRRLvKRLNALSDAMAAIAAGDLDVPIpvdg 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 207 --EVSALPRELKPLGQALNKMHHAL---VKDFER-----------LSQFAD---------DLAHELRTPINAL-----LG 256
Cdd:COG4192 379 ndEIGRIARLLRVFRDQAIEKTQELeteIEERKRieknlrqtqdeLIQAAKmavvgqtmtSLAHELNQPLNAMsmylfSA 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 257 QNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENilFLARADknnvlVKLDSLSLNKEVENLLDYLEYLSDEKEICFKV 336
Cdd:COG4192 459 KKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQ--FSRKSD-----TPLQPVDLRQVIEQAWELVESRAKPQQITLHI 531
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 337 ECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHItSFLDTNGYLNIDIASPGTKINEPEKLFRRFwrgdNSRHSEGQG 416
Cdd:COG4192 532 PDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISV-DLLSNAENLRVAISDNGNGWPLVDKLFTPF----TTTKEVGLG 606
|
410
....*....|....*.
gi 446749510 417 LGLSLVKAIAELHGGS 432
Cdd:COG4192 607 LGLSICRSIMQQFGGD 622
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
274-449 |
5.06e-11 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 64.10 E-value: 5.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 274 TIAGNIEELEN------ISRLTENIlflaradkNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKI 347
Cdd:COG3290 206 TISGLLQLGEYdealeyIDEISEEL--------QELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 348 ---LLQRMLSNLIVNAIRYS----PEKSRIHITsFLDTNGYLNIDIASPGTKINePEKLFRRFWRGDNSRHSEGQGLGLS 420
Cdd:COG3290 278 sdtDLVTILGNLLDNAIEAVeklpEEERRVELS-IRDDGDELVIEVEDSGPGIP-EELLEKIFERGFSTKLGEGRGLGLA 355
|
170 180 190
....*....|....*....|....*....|
gi 446749510 421 LVKAIAELHGGSATYHYFNKHN-VFRITLP 449
Cdd:COG3290 356 LVKQIVEKYGGTIEVESEEGEGtVFTVRLP 385
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
234-449 |
9.89e-11 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 63.46 E-value: 9.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 234 ERLS---QFADDLAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGNI-EELENISRLTENILFLARADKnnvlVKLDS 309
Cdd:COG5809 265 EKLSvvgELAAGIAHEIRNPLTSLKGFIQLLKD---TIDEEQKTYLDIMlSELDRIESIISEFLVLAKPQA----IKYEP 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 310 LSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLNIDI 386
Cdd:COG5809 338 KDLNTLIEEVIPLLQPQALLKNVQIELELEDDipdILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVVISV 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446749510 387 ASPGTKINEP--EKLFRRFWrgdnSRHSEGQGLGLSLVKAIAELHGGSATYHY-FNKHNVFRITLP 449
Cdd:COG5809 418 TDEGCGIPEErlKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKITVESeVGKGTTFSITLP 479
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-448 |
3.32e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 57.52 E-value: 3.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 334 FKVECN---QQIFA--DKILLQRMLSNLIVNAIRYSPEKSRIHITSFLD-TNGYlnIDIASPGTKINEP--EKLFRRFWR 405
Cdd:cd16947 1 FQVEINipdRPIYAnaNTEALQRILKNLISNAIKYGSDGKFLGMTLREDeKHVY--IDIWDKGKGISETekDHVFERLYT 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446749510 406 GDNSRHS--EGQGLGLSLVKAIAELHGGSATYH-YFNKHNVFRITL 448
Cdd:cd16947 79 LEDSRNSakQGNGLGLTITKRLAESMGGSIYVNsKPYEKTVFTVTL 124
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-435 |
2.32e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 55.33 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 314 KEVENLLDYLEYLSDEK--EICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEksRIHITSFLDTNG-YLNIDIASPG 390
Cdd:cd16954 1 PLLDSLCSALNKVYQRKgvSISLDISPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGlHLIVDDDGPG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446749510 391 TKINEPEKLFRRFWRGDNSRhsEGQGLGLSLVKAIAELHGGSATY 435
Cdd:cd16954 79 VPESQRSKIFQRGQRLDEQR--PGQGLGLAIAKEIVEQYGGELSL 121
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-434 |
2.66e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 54.39 E-value: 2.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 345 DKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGyLNIDIASPGTKINE--PEKLFRRFW---RGDNSRHSegQGLGL 419
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEG-IELLVFDEGSGIPDyaLNRVFERFYslpRPHSGQKS--TGLGL 77
|
90
....*....|....*
gi 446749510 420 SLVKAIAELHGGSAT 434
Cdd:cd16945 78 AFVQEVAQLHGGRIT 92
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
235-299 |
3.58e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 52.98 E-value: 3.58e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446749510 235 RLSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARAD 299
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
223-449 |
8.77e-09 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 57.43 E-value: 8.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 223 NKMHHALVKDFERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIagnIEELENISRLTENILFLARaD 299
Cdd:COG5805 271 KKEAEELMARSEKLSiagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIM---LSELDRIESIISEFLALAK-P 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 300 KNNVLVKLDSLSLNKEVENLLdYLEYLSDEKEICFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDT 378
Cdd:COG5805 347 QAVNKEKENINELIQDVVTLL-ETEAILHNIQIRLELlDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEED 425
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749510 379 NgYLNIDIASPGTKINEP--EKLFRRFWrgdnSRHSEGQGLGLSLVKAIAELHGGSATY-HYFNKHNVFRITLP 449
Cdd:COG5805 426 N-SVIIRVIDEGIGIPEErlKKLGEPFF----TTKEKGTGLGLMVSYKIIENHNGTIDIdSKVGKGTTFTITLP 494
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
1.08e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 52.71 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPEK--SRIHITSFLDTNGYLnIDIASPGTKINEP--EKLFRRFWRGDNSRHSEGQGLGLSLVKA 424
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWT-FYVRDNGIGIDPEyaEKVFGIFQRLHSREEYEGTGVGLAIVRK 79
|
90
....*....|
gi 446749510 425 IAELHGGSAT 434
Cdd:cd16921 80 IIERHGGRIW 89
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-449 |
1.42e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 52.29 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 345 DKILLQRMLSNLIVNAIRYSPEKSRIHITSFlDTNGYLNIDIASPGTKINEPE--KLFRRFWRGDNSRHS-EGQGLGLSL 421
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDlpRVFDKGFTGENGRNFqESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 446749510 422 VKAIAE-LHGGSATYHYFNKHNVFRITLP 449
Cdd:cd16948 81 VKKLCDkLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
237-449 |
1.53e-08 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 57.05 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 237 SQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEV 316
Cdd:PRK09959 713 SQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLV 792
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 317 ENLLDYLEYLSDEKEICfkVECNQQiFADKILL-------QRMLSNLIVNAIRYSPEKSrIHITSFL----DTNGYLNID 385
Cdd:PRK09959 793 QNTCHSFGAIAASKSIA--LSCSST-FPDHYLVkidpqafKQVLSNLLSNALKFTTEGA-VKITTSLghidDNHAVIKMT 868
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446749510 386 IASPGTKINEPE--KLFRRFWRGDNSRHSEGQGLGLSLVKA-IAELHGGSATYHYFNKHNVFRITLP 449
Cdd:PRK09959 869 IMDSGSGLSQEEqqQLFKRYSQTSAGRQQTGSGLGLMICKElIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
2.23e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.80 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPEKS-RIHITSFLDTNGY-LNIDIASPGTKINEPEKLFRRFW--RGDNSRHSEGQGLGLSLVKA 424
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTgRITVSAMPTGKMVtISVEDEGPGIPQEKLESIFDRFYteRPANEAFGQHSGLGLSISRQ 80
|
90
....*....|
gi 446749510 425 IAELHGGSAT 434
Cdd:cd16953 81 IIEAHGGISV 90
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
235-299 |
2.44e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 50.64 E-value: 2.44e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446749510 235 RLSQFADDLAHELRTPINALLGQNQVTLSQTRSiAEYQKTIAGNIEELENISRLTENILFLARAD 299
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-429 |
3.67e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 51.43 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIRYSPEKSRIHITSFLDTNG-YLNIDIASPGTKINEPEKLFRRFWRGDNSRHSE--GQGLGLSLVKAI 425
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGaRLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNtgGTGLGLAIVKHV 80
|
....
gi 446749510 426 AELH 429
Cdd:cd16952 81 MSRH 84
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
1.09e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 49.70 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 349 LQRMLSNLIVNAIR----YSPEKSRIHITSFLDTNGYLNIDI--ASPGTKINEPEKLFRRFWrgdnSRHSEGQGLGLSLV 422
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVTISVkdTGPGIAEEVAGQLFDPFY----TTKSEGLGMGLSIC 76
|
90 100 110
....*....|....*....|....*....|.
gi 446749510 423 KAIAELHGGSATyhyFNKHN----VFRITLP 449
Cdd:cd16920 77 RSIIEAHGGRLS---VESPAgggaTFQFTLP 104
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
184-432 |
1.31e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 53.87 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 184 LREIKKLSGVTEALNyNDSREPVEVSAlPRELKPLGQALNKMhhaLVKDFERLSQFA---DDLAHELRTPINALlgqnQV 260
Cdd:PRK10815 216 LRPIEALAKQVRELE-EGEREQLDPNP-PRELTSLVRNLNRL---LKNERERYTKYRttlTDLTHSLKTPLAVL----QS 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 261 TLsqtRSIAEYQKTiagNIEE-----LENISRLTENI-LFLARAD---KNNVLVK--------LDSL--SLNK-----EV 316
Cdd:PRK10815 287 TL---RSLRSGKQM---SVEQaepimLEQISRISQQIgYYLHRASmrsEHNLLSRelhsvaplLDNLtsALNKvyqrkGV 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 317 ENLLDYleylsdEKEICFKVECNQqifadkiLLQRMlSNLIVNAIRYSPEksRIHITSFLDTNG-YLNIDIASPGTKINE 395
Cdd:PRK10815 361 NITLDI------SPEITFVGEKND-------FMEVM-GNVLDNACKYCLE--FVEISARQTDEHlHIVVEDDGPGIPESK 424
|
250 260 270
....*....|....*....|....*....|....*..
gi 446749510 396 PEKLFRRFWRGDNSRhsEGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10815 425 RELIFDRGQRADTLR--PGQGLGLSVAREITEQYEGK 459
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
25-449 |
1.42e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 53.48 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 25 IVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDILIIHGDSINKIVNRTNVSDDMLNNI 104
Cdd:COG2972 23 LILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 105 PASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIVLCSVLSPLLIRTGL 184
Cdd:COG2972 103 LALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSIT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 185 REIKKLSGVTEALNYNDSREPVEVSALprELKPLGQALNKMH---HALVKDFERLSQfaddLAHELRtpINALlgQNQV- 260
Cdd:COG2972 183 RPIKRLKKAMKKVEKGDLVRLEVSGND--EIGILARSFNEMVeriKELIEEVYELEL----EKKEAE--LKAL--QAQIn 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 261 ------TLSQTRSIAEyqktiagnIEELENISRLTENILFLARA--DKNNVLVkldslSLNKEVENLLDYLE-----Yls 327
Cdd:COG2972 253 phflfnTLNSIRWLAE--------LEDPEEAEEMLEALSKLLRYslSKGDELV-----TLEEELELIKSYLEiqklrF-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 328 dEKEICFKVECNQQIfADKILLQRMLSNLIVNAIRY----SPEKSRIHITSFLDtNGYLNIDIASPGTKINEP--EKLFR 401
Cdd:COG2972 318 -GDRLEVEIEIDEEL-LDLLIPKLILQPLVENAIEHgiepKEGGGTIRISIRKE-GDRLVITVEDNGVGMPEEklEKLLE 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 446749510 402 RFwrgdnSRHSEGQGLGLSLVKAIAELH-GGSATYHYFNKHNVF---RITLP 449
Cdd:COG2972 395 EL-----SSKGEGRGIGLRNVRERLKLYyGEEYGLEIESEPGEGttvTIRIP 441
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
236-449 |
1.76e-06 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 50.17 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 236 LSQFADDLAHELRTPinallgqnqvtLSQTRSIAEY--QKTIAGN---------IEELENISRLTENILFLARADKnnvl 304
Cdd:PRK10364 237 LGHLAAGVAHEIRNP-----------LSSIKGLAKYfaERAPAGGeahqlaqvmAKEADRLNRVVSELLELVKPTH---- 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 305 VKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGy 381
Cdd:PRK10364 302 LALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTlpeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAG- 380
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446749510 382 LNIDIASPGTKI--NEPEKLFRRFWRGDNsrhsEGQGLGLSLVKAIAELHGG--SATYHYfNKHNVFRITLP 449
Cdd:PRK10364 381 VKISVTDSGKGIaaDQLEAIFTPYFTTKA----EGTGLGLAVVHNIVEQHGGtiQVASQE-GKGATFTLWLP 447
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
237-449 |
4.89e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.08 E-value: 4.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 237 SQFADDLAHELRTPINALLG------QNQVTLSQTrsiaEYQKTI---AGN----IEELENISRL------TENILFLAR 297
Cdd:PRK11107 294 SEFLANMSHELRTPLNGVIGftrqtlKTPLTPTQR----DYLQTIersANNllaiINDILDFSKLeagklvLENIPFSLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 298 AdknnvlvkldslSLNkEVENLldyLEYLSDEKEICFKVECNQQI----FADKILLQRMLSNLIVNAIRYSPEKS---RI 370
Cdd:PRK11107 370 E------------TLD-EVVTL---LAHSAHEKGLELTLNIDPDVpdnvIGDPLRLQQIITNLVGNAIKFTESGNidiLV 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 371 HITSFLDTNGYLNIDIASPGTKINEP--EKLFRRFWRGDNS---RHSeGQGLGLSLVKAIAELHGGSATYHY-FNKHNVF 444
Cdd:PRK11107 434 ELRALSNTKVQLEVQIRDTGIGISERqqSQLFQAFRQADASisrRHG-GTGLGLVITQKLVNEMGGDISFHSqPNRGSTF 512
|
....*
gi 446749510 445 RITLP 449
Cdd:PRK11107 513 WFHLP 517
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
239-431 |
1.41e-05 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 47.63 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 239 FADDLAHELRTPINALLGQNQVTLsQTRSIAE---YQKTIAGNIEELENIsrlTENILFLARADKNNvlVKLDSLSLNke 315
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILL-DTELTAEqrkYLKTIHVSAITLGNI---FNDIIDMDKMERRK--LQLDNQPID-- 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 316 VENLLDYLEYLS----DEKEICFKVECN----QQIFADKILLQRMLSNLIVNAIRYSpEKSRIHITSFLDTNGYLNIDIA 387
Cdd:PRK11091 358 FTDFLADLENLSglqaEQKGLRFDLEPLlplpHKVITDGTRLRQILWNLISNAVKFT-QQGGVTVRVRYEEGDMLTFEVE 436
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 446749510 388 SPGTKI--NEPEKLFRRFWR---GDNSRHSEGQGLGLSLVKAIAELHGG 431
Cdd:PRK11091 437 DSGIGIpeDELDKIFAMYYQvkdSHGGKPATGTGIGLAVSKRLAQAMGG 485
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
176-451 |
1.45e-05 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 47.59 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 176 SPLLIRTGLREIKKLSGVTEALNYNdsrepveVSALPR---ELKPLGQALNKMHHALV-----------KDFERLSQFAD 241
Cdd:PRK11466 377 SPFPETAGVRELDTIGRLMDAFRSN-------VHALNRhreQLAAQVKARTAELQELViehrqaraeaeKASQAKSAFLA 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 242 DLAHELRTPINALLGQNQVTLSQTRSIA--EYQKTIAGNIEELENIsrLTENILFLA-RADKNNVLVKLDSLSLNKEVEN 318
Cdd:PRK11466 450 AMSHEIRTPLYGILGTAQLLADNPALNAqrDDLRAITDSGESLLTI--LNDILDYSAiEAGGKNVSVSDEPFEPRPLLES 527
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 319 LLDYLEYLSDEKEICFKVECNQQIFA----DKILLQRMLSNLIVNAIRYSpEKSRIHITSFLDTNGYLnIDIASPGTKIN 394
Cdd:PRK11466 528 TLQLMSGRVKGRPIRLATDIADDLPTalmgDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWL-VEVEDSGCGID 605
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446749510 395 EPEK--LFRRFWRGDNSRHseGQGLGLSLVKAIAELHGG----SATYHyfnKHNVFRITLPQR 451
Cdd:PRK11466 606 PAKLaeIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGelsaTSTPE---VGSCFCLRLPLR 663
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-434 |
1.84e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 43.43 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 352 MLSNLIVNAI----RYSPEKSRIHItSFLDTNGYLNIDIASPGTKInEPEKLFRRFWRGDNSRHSEGQGLGLSLVKAIAE 427
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEV-FLRDEGDDLVIEVRDTGPGI-APELRDKVFERGVSTKGQGERGIGLALVRQSVE 81
|
....*..
gi 446749510 428 LHGGSAT 434
Cdd:cd16915 82 RLGGSIT 88
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-432 |
1.45e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 40.87 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 348 LLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLnIDIASPGTKInEPE---KLFRRFWrgDNSRHSEGQGLGLSLVKA 424
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVL-IEVEDTGSGI-DPEilgRIFDPFF--TTKPVGEGTGLGLSLSYR 78
|
....*...
gi 446749510 425 IAELHGGS 432
Cdd:cd16943 79 IIQKHGGT 86
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
413-449 |
3.55e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 40.08 E-value: 3.55e-04
10 20 30
....*....|....*....|....*....|....*..
gi 446749510 413 EGQGLGLSLVKAIAELHGGSATYHYFNKHNVFRITLP 449
Cdd:cd16918 73 NGTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
220-434 |
6.13e-04 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 42.32 E-value: 6.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 220 QALNKMHHALVKDFERLSQFADDLAHELRTPINALLG-----QN-QVTLSQtRSIAEYQKTIAGNIEELENisrlteNIL 293
Cdd:PRK15347 382 QALAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGalellQNtPLTAEQ-MDLADTARQCTLSLLAIIN------NLL 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 294 FLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQI----FADKILLQRMLSNLIVNAIRYSPEKS- 368
Cdd:PRK15347 455 DFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVplylHLDSLRLRQILVNLLGNAVKFTETGGi 534
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446749510 369 RIHITSFLDTNgYLNIDIASPGTKINEPEKLFRRFWRGDNsrHSEGQGLGLSLVKAIAELHGGSAT 434
Cdd:PRK15347 535 RLRVKRHEQQL-CFTVEDTGCGIDIQQQQQIFTPFYQADT--HSQGTGLGLTIASSLAKMMGGELT 597
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
341-427 |
1.19e-03 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 41.50 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 341 QIFADKILLQRMLSNLIVNAIRYSpEKSRIHITSFLDtNGYLNIDIASPGTKINEPE--KLFRRFWR-GDN-SRHSEGQG 416
Cdd:PRK10841 555 ALNGDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVD-GDYLSFRVRDTGVGIPAKEvvRLFDPFFQvGTGvQRNFQGTG 632
|
90
....*....|.
gi 446749510 417 LGLslvkAIAE 427
Cdd:PRK10841 633 LGL----AICE 639
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
238-361 |
3.43e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 39.92 E-value: 3.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749510 238 QFADDLAHELRTPINALlGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVE 317
Cdd:PRK10618 452 AFLQNIGDELKQPLQSL-AQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLID 530
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446749510 318 NLLdyLEYLSDEKE------ICFKVECNQQIFADKILLQRMLSNLIVNAI 361
Cdd:PRK10618 531 EVL--PEVLPAIKRkglqllIHNHLKAEQLRIGDRDALRKILLLLLNYAI 578
|
|
| |
