|
Name |
Accession |
Description |
Interval |
E-value |
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
3-449 |
7.69e-89 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 277.73 E-value: 7.69e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 3 RLSITVRLTLLFILVLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDT----LPVYFNRMMDVSQD 78
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEdikrLQEKIDDLLVGHSD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 79 ILIihgdSINKIVNRTNVSDDMLNNIPATETISAAG-IYRSIINDTEIDALRINIDEVSP------SLTVTVAKLASARH 151
Cdd:TIGR01386 81 LAL----SILNPDGRLLFERAQGAALVPAVAANDALlELDQADAKMTHYRSILRSVAALPggkgrkPVQITVALDINAHT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 152 NMLEQYKINSIIICIVAIILCSVLSPLLIRTGLREIKKLSGVTEALNYNDNREPVEVSALPRELKPLGQALNKMHQALVK 231
Cdd:TIGR01386 157 HLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLED 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 232 DFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLS 311
Cdd:TIGR01386 237 AFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 312 LNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILItSFLDTNGSLNIDIASPGT 391
Cdd:TIGR01386 317 LAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITV-RIERRSDEVRVSVSNPGP 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446749551 392 KINEP--EKLFRRFWRGDNSRH--SVGQGLGLSLVKAIAELHGGSATYHYLNKLNVFRITLP 449
Cdd:TIGR01386 396 GIPPEhlSRLFDRFYRVDPARSnsGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
221-452 |
3.20e-46 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 160.07 E-value: 3.20e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 221 ALNKMHQALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNI-EELENISRLTENILFLARAD 299
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIrESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 300 KNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRILITSFL 376
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElplVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446749551 377 DtNGSLNIDIASPGTKINEP--EKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHY-LNKLNVFRITLPQRN 452
Cdd:COG2205 161 E-GDGVRISVSDNGPGIPEEelERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESePGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
175-449 |
7.98e-46 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 161.61 E-value: 7.98e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 175 LSPLLIRTGLREIKKLSGVTEALNYNDNREPVEVSALPRELKPLGQALNKMHQALVKDFERLSQFADDLAHELRTPINAL 254
Cdd:COG0642 49 LLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 255 LGQNQVTLSQTRsiAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICF 334
Cdd:COG0642 129 RGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIEL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 335 KVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDtNGSLNIDIASPGTKINEP--EKLFRRFWRGDNS 409
Cdd:COG0642 207 ELDLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE-GDRVRISVEDTGPGIPPEdlERIFEPFFRTDPS 285
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446749551 410 RHSVGQGLGLSLVKAIAELHGGSATYHY-LNKLNVFRITLP 449
Cdd:COG0642 286 RRGGGTGLGLAIVKRIVELHGGTIEVESePGKGTTFTVTLP 326
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
178-451 |
9.74e-43 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 157.24 E-value: 9.74e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 178 LLIRTGLREIKKLSGVTEALNYNDNREPVEVSALPRELKPLGQALNKMHQALVKDFERLSQFADDLAHELRTPINALLGQ 257
Cdd:PRK09835 204 LAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQ 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 258 NQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVE 337
Cdd:PRK09835 284 TEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFV 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 338 CNQ-QIFADKILLQRMLSNLIVNAIRYSPEKSRILItSFLDTNGSLNIDIASPGTKINEPE--KLFRRFWRGDNSRHSVG 414
Cdd:PRK09835 364 GDPcQVAGDPLMLRRAISNLLSNALRYTPAGEAITV-RCQEVDHQVQLVVENPGTPIAPEHlpRLFDRFYRVDPSRQRKG 442
|
250 260 270
....*....|....*....|....*....|....*....
gi 446749551 415 Q--GLGLSLVKAIAELHGGSATYHYLNKLNVFRITLPQR 451
Cdd:PRK09835 443 EgsGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLPRL 481
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
1.36e-42 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 145.61 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPEKSRILITSFLDTNgSLNIDIASPGTKINE--PEKLFRRFWRGDNSRHSVGQGLGLSLVKAIA 426
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDD-VVNIMFKNPSSHPLDfkLEKLFERFYRGDNSRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|...
gi 446749551 427 ELHGGSATYHYLNKLNVFRITLP 449
Cdd:cd16923 80 ELHGGSASAEYDDNHDLFKVRLP 102
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
115-449 |
1.05e-40 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 149.70 E-value: 1.05e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 115 IYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIILCSVLSPLLIRTGLREIKKLSGVT 194
Cdd:COG5002 44 LLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 195 EALNYNDNREPVEVSALPRELKPLGQALNKMHQALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQ-TRSIAEYQK 273
Cdd:COG5002 124 LLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERRE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 274 TIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQ 350
Cdd:COG5002 204 YLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpllVLGDPDRLE 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 351 RMLSNLIVNAIRYSPEKSRILITSFLDtNGSLNIDIASPGTKINEP--EKLFRRFWRGDNS--RHSVGQGLGLSLVKAIA 426
Cdd:COG5002 284 QVLTNLLDNAIKYTPEGGTITVSLREE-DDQVRISVRDTGIGIPEEdlPRIFERFYRVDKSrsRETGGTGLGLAIVKHIV 362
|
330 340
....*....|....*....|....
gi 446749551 427 ELHGGSATYHY-LNKLNVFRITLP 449
Cdd:COG5002 363 EAHGGRIWVESePGKGTTFTITLP 386
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
185-436 |
1.45e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 102.62 E-value: 1.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 185 REIKKLSGVTEALNYNdnrEPVEVSAL-PRELKPLGQALNKMHQALV-KDF-ERLSQfadDLAHELRTPINALLGQNQvt 261
Cdd:PRK11100 208 RSIRRLTRYADAVTEG---KPVPLPKLgSSELRELAQALESMRVKLEgKAYvEQYVQ---TLTHELKSPLAAIRGAAE-- 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 262 LSQTRSIAEYQKTIAGNIE-ELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVEC-N 339
Cdd:PRK11100 280 LLQEDPPPEDRARFTGNILtQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPdD 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 340 QQIFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDtNGSLNIDIASPGTKINEP--EKLFRRFW---RGDNSRHSvg 414
Cdd:PRK11100 360 ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVD-GEQVALSVEDQGPGIPDYalPRIFERFYslpRPANGRKS-- 436
|
250 260
....*....|....*....|..
gi 446749551 415 QGLGLSLVKAIAELHGGSATYH 436
Cdd:PRK11100 437 TGLGLAFVREVARLHGGEVTLR 458
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
171-431 |
2.19e-22 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 99.13 E-value: 2.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 171 LCSVLSPLLIRTGLRE-IKKLSGVTEALNYNDNREPVEVSAlPRELKPLGQALNKMHQALVKDFERLSQFADDLAHELRT 249
Cdd:NF012163 175 LLAALAAFLLARGLLApVKRLVEATHRLAAGDYTTRVTPTS-NDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 250 PINALLGQNQVTLSQTRSIAeyQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLS----LNKEVENLLDYLEy 325
Cdd:NF012163 254 PLAVLRAELEAIQDGIRKFT--PESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDlvplLEVEGGAFRERFA- 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 326 lSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILI-TSFLDTNGSLNIDIASPGTKINEPEKLFRRFW 404
Cdd:NF012163 331 -SAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHIsASQRPKEVTLTVADSAPGVSDEQLARLFERFY 409
|
250 260
....*....|....*....|....*....
gi 446749551 405 RGDNSRH--SVGQGLGLSLVKAIAELHGG 431
Cdd:NF012163 410 RVEVSRNraSGGSGLGLAISLNIVQAHGG 438
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
178-435 |
4.88e-22 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 98.18 E-value: 4.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 178 LLIRTGL--REIKKLSGVTEALNYN--DNREPVEVSALPRELKPLGQALN----KMHQALVKdfERlsQFADDLAHELRT 249
Cdd:PRK10337 175 LIILMVLlgRELAPLKKLALALRMRdpDSETPLNATGVPSEVRPLVEALNqlfaRTHAMMVR--ER--RFTSDAAHELRS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 250 PINALLGQNQVT-LSQTRSIAEyQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSD 328
Cdd:PRK10337 251 PLAALKVQTEVAqLSDDDPQAR-KKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQ 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 329 EKEICFKVECNqqifADKI-------LLQRMLSNLIVNAIRYSPEKSRILITSfldTNGSLNIDIASPGTkinEPEKLFR 401
Cdd:PRK10337 330 QAGIDVRLTLN----AHPVirtgqplLLSLLVRNLLDNAIRYSPQGSVVDVTL---NARNFTVRDNGPGV---TPEALAR 399
|
250 260 270
....*....|....*....|....*....|....*..
gi 446749551 402 ---RFWRgDNSRHSVGQGLGLSLVKAIAELHGGSATY 435
Cdd:PRK10337 400 igeRFYR-PPGQEATGSGLGLSIVRRIAKLHGMNVSF 435
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
349-448 |
5.54e-22 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 89.97 E-value: 5.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPEKSRILITSFLDTNGsLNIDIASPGTKINE--PEKLFRRFWRGDNSRHSVGQGLGLSLVKAIA 426
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDG-VVLEVEDNGPGIPEedLERIFERFYRGDKSREGGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 446749551 427 ELHGGSATYHY-LNKLNVFRITL 448
Cdd:cd00075 80 EAHGGRITVESePGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
344-451 |
1.94e-21 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 88.86 E-value: 1.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 344 ADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDtNGSLNIDIASPGTKINE--PEKLFRRFWRGDNSRHSVGQ-GLGLS 420
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERD-GDHVEITVEDNGPGIPPedLEKIFEPFFRTDKRSRKIGGtGLGLS 79
|
90 100 110
....*....|....*....|....*....|....
gi 446749551 421 LVKAIAELHGGsaTYHYLNKLN---VFRITLPQR 451
Cdd:smart00387 80 IVKKLVELHGG--EISVESEPGggtTFTITLPLE 111
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-432 |
8.50e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 87.08 E-value: 8.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 339 NQQIFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNGSLNIDIASPGTKINEPEKLFRRFWRGDnSRHSVGQGLG 418
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSD-GQNYGGSGLG 82
|
90
....*....|....
gi 446749551 419 LSLVKAIAELHGGS 432
Cdd:cd16940 83 LSIVKRIVELHGGQ 96
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
201-431 |
2.40e-20 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 91.95 E-value: 2.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 201 DNREPVEVSALPRELKPLGQALNKMHQALVKDFERLSQFADDLAHELRTPINA------LLGQNQVTLSQTRsiaeyqkt 274
Cdd:PRK10755 102 DNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGirlhleLLEKQHHIDVAPL-------- 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 275 iagnIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEV----ENLLDYLEYLSDEKEICFKVECNQQIFADKILLQ 350
Cdd:PRK10755 174 ----IARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVilpsQDELSEMLEQRQQTLLLPESAADITVQGDATLLR 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 351 RMLSNLIVNAIRYSPEKSRILITSFLDTNGS-LNIDIASPG---TKINEPEKLFRRFwrgdNSRHSvGQGLGLSLVKAIA 426
Cdd:PRK10755 250 LLLRNLVENAHRYSPEGSTITIKLSQEDGGAvLAVEDEGPGideSKCGELSKAFVRM----DSRYG-GIGLGLSIVSRIT 324
|
....*
gi 446749551 427 ELHGG 431
Cdd:PRK10755 325 QLHHG 329
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
71-452 |
1.76e-19 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 90.61 E-value: 1.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 71 RMMDVSQDILIIHGDSINKIVNRTNVSDDMLNNIPATETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASAR 150
Cdd:COG4251 117 ELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLL 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 151 HNMLEQYKINSIIICIVAIILCSVLSPLLIRTGLREIKKLSGVTEALNYNDNREPVEVSALPRELKPLGQALNKMHQALV 230
Cdd:COG4251 197 LLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELE 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 231 KDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRS-----IAEYQKTIAGNIEELeniSRLTENILFLARADKNNVlv 305
Cdd:COG4251 277 RSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDkldeeGREYLERIRDAAERM---QALIDDLLAYSRVGRQEL-- 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 306 KLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILIT-SFLDTNGSLNI 384
Cdd:COG4251 352 EFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEiGAEREGGEWVF 431
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446749551 385 DIASPGTKINEP--EKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHylNKLN---VFRITLPQRN 452
Cdd:COG4251 432 SVRDNGIGIDPEyaEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVE--SEPGegaTFYFTLPKAP 502
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
209-432 |
1.93e-19 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 90.05 E-value: 1.93e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 209 SALPRelkpLGQALNKMH---QALVKDFErlsQFADDLAHELRTPINALlgQNQVTLSQTRSIAEyQKTIAGNIEELENi 285
Cdd:PRK10604 189 SSLER----LGVAFNQMAdniNALIASKK---QLIDGIAHELRTPLVRL--RYRLEMSDNLSAAE-SQALNRDIGQLEA- 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 286 srLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEI-CFKVECNQQIFADKILLQRMLSNLIVNAIRYS 364
Cdd:PRK10604 258 --LIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVrLDTPHQGDYGALDMRLMERVLDNLLNNALRYA 335
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 365 PEKSRILITsFLDTNGSLNIDIASPGTKINEPEKLFRRFWRGDNSRH--SVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10604 336 HSRVRVSLL-LDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDraTGGCGLGLAIVHSIALAMGGS 404
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
214-451 |
2.82e-19 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 90.08 E-value: 2.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 214 ELKPLGQALNKMHQAL------VKDFERLSQ-FADDLAHELRTPINA------LLGQNQVTL-SQTRSIAEYQKTiagni 279
Cdd:NF040691 242 DLARLARSFNQMADSLqrqirqLEELSRLQQrFVSDVSHELRTPLTTirmaadVIHDSRDDFdPATARSAELLHT----- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 280 eELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIF---ADKILLQRMLSNL 356
Cdd:NF040691 317 -ELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVvaeVDPRRVERVLRNL 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 357 IVNAIRYSpEKSRILITsfLDTNGS---LNIDIASPGTKINEPEKLFRRFWRGDNSR--HSVGQGLGLSLVKAIAELHGG 431
Cdd:NF040691 396 VVNAIEHG-EGKPVVVT--VAQDDTavaVTVRDHGVGLKPGEVALVFDRFWRADPARarTTGGTGLGLAIALEDARLHGG 472
|
250 260
....*....|....*....|....*....
gi 446749551 432 satyhylnKLNV---------FRITLPQR 451
Cdd:NF040691 473 --------WLEAwgrpgqgsqFRLTLPRV 493
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
344-452 |
3.23e-18 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 79.72 E-value: 3.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 344 ADKILLQRMLSNLIVNAIRYSPEKSRILITsfLDTNGSLNIDIASPGTKINEP--EKLFRRFWRGDNSRHSvGQGLGLSL 421
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT--LSEGGELTLTVEDNGIGIPPEdlPRIFEPFSTADKRGGG-GTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 446749551 422 VKAIAELHGGSATYHYLNKLN-VFRITLPQRN 452
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGtTVTLTLPLAQ 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
243-450 |
3.70e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 87.40 E-value: 3.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 243 LAHELRTPINALLGQNQV-TLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLLD 321
Cdd:PRK10490 671 LSHDLRTPLTVLFGQAEIlTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQ 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 322 YLEYLSDEKEIcfKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNgSLNIDI--ASPGTKINEP 396
Cdd:PRK10490 751 MLEPGLSGHPI--NLSLPEPltlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGE-RLQLDVwdNGPGIPPGQE 827
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446749551 397 EKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHylNKLN---VFRITLPQ 450
Cdd:PRK10490 828 QLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAE--NRPEggaCFRVTLPL 882
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
243-449 |
4.70e-18 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 85.78 E-value: 4.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 243 LAHELR---TPI--NALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNnvlvKLDSLSLNKEVE 317
Cdd:COG5000 208 IAHEIKnplTPIqlSAERLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEP----QLEPVDLNELLR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 318 NLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDtNGSLNIDIASPGTKIN 394
Cdd:COG5000 284 EVLALYEPALKEKDIRLELDLDPDlpeVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE-DGRVRIEVSDNGPGIP 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 395 EP--EKLFRRFwrgdNSRHSVGQGLGLSLVKAIAELHGGSATYHylNKLN---VFRITLP 449
Cdd:COG5000 363 EEvlERIFEPF----FTTKPKGTGLGLAIVKKIVEEHGGTIELE--SRPGggtTFTIRLP 416
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
201-431 |
1.02e-17 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 83.80 E-value: 1.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 201 DNREPVE-VSALPRELK------PLGqalNKMHQALVKDFERLSQ-------FADDLAHELRTPINALLGQNQvTLSQTR 266
Cdd:TIGR02966 68 RFSEPLElPSPINSERVleiriaPYG---EEQKLLVARDVTRLRRleqmrrdFVANVSHELRTPLTVLRGYLE-TLADGP 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 267 SI--AEYQKTIAGNIEELENISRLTENILFLAR-----ADKNNVLVKLDSLslnkeVENLLDYLEYLSDEKE--ICFKVE 337
Cdd:TIGR02966 144 DEdpEEWNRALEIMLEQSQRMQSLVEDLLTLSRlesaaSPLEDEPVDMPAL-----LDHLRDEAEALSQGKNhqITFEID 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 338 CNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDtNGSLNIDIASPGTKInEPE---KLFRRFWRGD--NSRHS 412
Cdd:TIGR02966 219 GGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRD-GGGAEFSVTDTGIGI-APEhlpRLTERFYRVDksRSRDT 296
|
250
....*....|....*....
gi 446749551 413 VGQGLGLSLVKAIAELHGG 431
Cdd:TIGR02966 297 GGTGLGLAIVKHVLSRHHA 315
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
207-449 |
5.53e-16 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 79.07 E-value: 5.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 207 EVSALPRELKPLGQALNKMHQAlvkdfERLS---QFADDLAHELRTPINALLGQNQV---TLSQTRSIAEYQKTIAGNIE 280
Cdd:COG4191 115 DITELERAEEELRELQEQLVQS-----EKLAalgELAAGIAHEINNPLAAILGNAELlrrRLEDEPDPEELREALERILE 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 281 ELENISRLTENILFLARADKnnvlVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQ---QIFADKILLQRMLSNLI 357
Cdd:COG4191 190 GAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVELDLPPdlpPVLGDPGQLEQVLLNLL 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 358 VNAIRYSPEKS--RILITSFLDtNGSLNIDIASPGTKINEP--EKLFRRFW----RGDnsrhsvGQGLGLSLVKAIAELH 429
Cdd:COG4191 266 INAIDAMEEGEggRITISTRRE-GDYVVISVRDNGPGIPPEvlERIFEPFFttkpVGK------GTGLGLSISYGIVEKH 338
|
250 260
....*....|....*....|...
gi 446749551 430 GGSATYHylNKLN---VFRITLP 449
Cdd:COG4191 339 GGRIEVE--SEPGggtTFTITLP 359
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
178-432 |
2.55e-15 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 77.75 E-value: 2.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 178 LLIRTGLREIKKLSGVTEALNYNDNREPVEVSAlPRELKPLGQALNKMHQALVKDFERLSQFADDLAHELRTPINALLG- 256
Cdd:PRK10549 183 LLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTS-RDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGe 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 257 ----QNQVTLSQTRSIAEYQKtiagnieELENISRLTENILFLARADknnvlvkLDSLSLNKEVENLLDYLE-------- 324
Cdd:PRK10549 262 leaiQDGVRKFTPESVASLQA-------EVGTLTKLVDDLHQLSLSD-------EGALAYRKTPVDLVPLLEvaggafre 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 325 -YLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNG-SLNIDIASPGTKINEPEKLFRR 402
Cdd:PRK10549 328 rFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTlRLTFADSAPGVSDEQLQKLFER 407
|
250 260 270
....*....|....*....|....*....|..
gi 446749551 403 FWRGDNSRH--SVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10549 408 FYRTEGSRNraSGGSGLGLAICLNIVEAHNGR 439
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
193-431 |
7.71e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 76.55 E-value: 7.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 193 VTEALNYNDNREPVEVSALPRELKPLGQALNKMHQAlvkdfERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIa 269
Cdd:PRK11360 349 VSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQ-----ERLAalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP- 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 270 EYQKTIAGNIEELENISRLTENILFLARADKnnvlVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADK 346
Cdd:PRK11360 423 PSQEYLSVVLREVDRLNKVIDQLLEFSRPRE----SQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNElppIWADP 498
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 347 ILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNGSLNIDIASPGTKInEPE---KLFRRFWrgdnSRHSVGQGLGLSLVK 423
Cdd:PRK11360 499 ELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGI-DPEllkKIFDPFF----TTKAKGTGLGLALSQ 573
|
....*...
gi 446749551 424 AIAELHGG 431
Cdd:PRK11360 574 RIINAHGG 581
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
212-450 |
8.25e-15 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 75.42 E-value: 8.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 212 PRELKPLGQALNKMHQALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGN-IEELENISRLTE 290
Cdd:NF012226 114 SAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQGRLQGILD---GVFEPDPALFKSlLNQVEGLSHLVE 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 291 NILFLARADKNNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVE-CNQQIFADKILLQRMLSNLIVNAIRYSpEKSR 369
Cdd:NF012226 191 DLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNlTATPVFCDRRRIEQVLIALIDNAIRYA-NAGK 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 370 ILITSFLDTNG-SLNIDIASPGTKINEPEKLFRRFWRGDNSRHSV--GQGLGLSLVKAIAELHGGSATYHYLNKLNVFRI 446
Cdd:NF012226 270 LKISSSVIQDDwILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEfgGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTI 349
|
....
gi 446749551 447 TLPQ 450
Cdd:NF012226 350 KLPA 353
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
239-451 |
2.26e-14 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 74.66 E-value: 2.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 239 FADdLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNnvlvklDSLSLNKEVE- 317
Cdd:PRK11006 208 FAN-VSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAA------PTIDLNEKVDv 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 318 -NLLDYLEY----LSDEK-EICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNGSLnIDIASPGT 391
Cdd:PRK11006 281 pMMLRVLEReaqtLSQGKhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAE-FSVEDNGP 359
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749551 392 KInEPEKLFR---RFWRGDN--SRHSVGQGLGLSLVKaiaelHggsATYHYLNKLNV---------FRITLPQR 451
Cdd:PRK11006 360 GI-APEHIPRlteRFYRVDKarSRQTGGSGLGLAIVK-----H---ALSHHDSRLEIesevgkgtrFSFVLPER 424
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
5.20e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 67.74 E-value: 5.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPEKsrILITSFLDTNG-SLNIDIASPGTKINEPEKLFRRFWRGDNSR--HSVGQGLGLSLVKAI 425
Cdd:cd16949 1 LARALENVLRNALRYSPSK--ILLDISQDGDQwTITITDDGPGVPEDQLEQIFLPFYRVDSARdrESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 446749551 426 AELHGGS--ATYHYLNKLNVfRITLP 449
Cdd:cd16949 79 IEQHGGKikASNRKPGGLRV-RIWLP 103
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-432 |
1.54e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 66.72 E-value: 1.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 345 DKILLQRMLSNLIVNAIRYSPEKSRILI-TSFLDTNGSLNIDIASPGTKINEPEKLFRRFWRGDNSRH--SVGQGLGLSL 421
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIrAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNraSGGSGLGLAI 80
|
90
....*....|.
gi 446749551 422 VKAIAELHGGS 432
Cdd:cd16946 81 CHNIALAHGGT 91
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
212-432 |
2.06e-13 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 71.89 E-value: 2.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 212 PRELKPLGQALNKMHQAL---VKDFERLsqfADDLAHELRTPI------NALLgqnqvtlsqTRSIAEYQKT--IAGNIE 280
Cdd:PRK09470 219 PQEFRQAGASFNQMVTALermMTSQQRL---LSDISHELRTPLtrlqlaTALL---------RRRQGESKELerIETEAQ 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 281 ELEN-ISRLteniLFLARADKNNVLVKlDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNL 356
Cdd:PRK09470 287 RLDSmINDL----LVLSRNQQKNHLER-ETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGpwpINGNPNALASALENI 361
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446749551 357 IVNAIRYSpeKSRILITSFLDTNG-SLNIDIASPGTKINEPEKLFRRFWRGDNS--RHSVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK09470 362 VRNALRYS--HTKIEVAFSVDKDGlTITVDDDGPGVPEEEREQIFRPFYRVDEArdRESGGTGLGLAIVENAIQQHRGW 438
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
2.84e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 65.55 E-value: 2.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSpeKSRILITSFLDTNGsLNIDIASPGTKINEPE--KLFRRFWRGDNSRHSVGQGLGLSLVKAIA 426
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNR-TRIQVLDNGPGIAPEEvdELFQPFYRGDNARGTSGTGLGLAIVQRIS 77
|
....*...
gi 446749551 427 ELHGGSAT 434
Cdd:cd16950 78 DAHGGSLT 85
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
344-436 |
1.07e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 64.44 E-value: 1.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 344 ADKIllQRMLSNLIVNAIRYSPEKSRI-LITSFLDTNGSL-NIDIASPGTKINEPEKLFRRFWRG--DNSRHSVGQGLGL 419
Cdd:cd16925 2 AEKY--ERVVLNLLSNAFKFTPDGGRIrCILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGL 79
|
90
....*....|....*..
gi 446749551 420 SLVKAIAELHGGSATYH 436
Cdd:cd16925 80 SIVKEFVELHGGTVTVS 96
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
329-432 |
2.67e-12 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 68.40 E-value: 2.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 329 EKEICFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSpeKSRILITSFLDT---------NGslnidiasPGTKINEPEK 398
Cdd:PRK09467 311 EREIETALqPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGkrawfqvedDG--------PGIPPEQLKH 380
|
90 100 110
....*....|....*....|....*....|....
gi 446749551 399 LFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGS 432
Cdd:PRK09467 381 LFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGK 414
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-434 |
7.87e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 61.71 E-value: 7.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 345 DKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNgSLNIDIASPGTKINEP--EKLFRRFWRGDNSRHSVGQ-GLGLSL 421
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEE-YLYFEIWDNGHGFSEQdlKKALELFYRDDTSRRSGGHyGMGLYI 79
|
90
....*....|...
gi 446749551 422 VKAIAELHGGSAT 434
Cdd:cd16975 80 AKNLVEKHGGSLI 92
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
236-449 |
2.00e-11 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 65.25 E-value: 2.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 236 LSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKnnvlVKLDSLSLNKE 315
Cdd:COG3852 135 VGELAAGLAHEIRNPLTGIRGAAQL-LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 316 VENLLDYLEYLSDeKEICFKVECNQ---QIFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNGSLN--------- 383
Cdd:COG3852 210 LERVLELLRAEAP-KNIRIVRDYDPslpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLGglrprlyvr 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446749551 384 IDIASPGTKINEP--EKLFRRFW--RGDnsrhsvGQGLGLSLVKAIAELHGGSATYH-YLNKLNVFRITLP 449
Cdd:COG3852 289 IEVIDNGPGIPEEilDRIFEPFFttKEK------GTGLGLAIVQKIVEQHGGTIEVEsEPGKGTTFRIYLP 353
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
243-431 |
2.25e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 64.97 E-value: 2.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 243 LAHELRTPINAL--------LGQNQ-VTLSQTRSIAEYQKTIAgniEELENISRLTENILFLARAdKNNVL----VKLDS 309
Cdd:PRK09303 158 LAHDLRTPLTAAslaletleLGQIDeDTELKPALIEQLQDQAR---RQLEEIERLITDLLEVGRT-RWEALrfnpQKLDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 310 LSLNKEVenLLDYLEYLSdEKEICFKVECNQQI---FADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNGSLNIDI 386
Cdd:PRK09303 234 GSLCQEV--ILELEKRWL-AKSLEIQTDIPSDLpsvYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVQVSI 310
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446749551 387 AS--PGTKINEPEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGG 431
Cdd:PRK09303 311 CDtgPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-433 |
3.03e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 59.75 E-value: 3.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPEKSRIlitSFLDTNGSLNIDIAS--PGTKINEPEKLFRRFWRGDNSR--HSVGQGLGLSLVKA 424
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRI---ALLVSGGRLTLIVEDdgPGIPAAARERVFEPFVRLDPSRdrATGGFGLGLAIVHR 77
|
....*....
gi 446749551 425 IAELHGGSA 433
Cdd:cd16939 78 VALWHGGHV 86
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
245-431 |
8.30e-11 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 64.00 E-value: 8.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 245 HELRTPinallgqnqvtLSQTRSIAE------YQ-KTIAGNI-----EELENISRLTENILFLARADKNNVLVKLDSLSL 312
Cdd:NF033092 381 HELRTP-----------LTTMRSYLEaladgaWKdPELAPRFlgvtqNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNF 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 313 NKEVENLLDYLEYLSDEKEICFKVEC-NQQIFA----DKIllQRMLSNLIVNAIRYSPEKSRILItSFLDTNGSLNIDIA 387
Cdd:NF033092 450 NEFFNYIIDRFEMILKNKNITFKREFpKRDLWVeidtDKI--TQVLDNIISNAIKYSPEGGTITF-RLLETHNRIIISIS 526
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 446749551 388 SPGTKI--NEPEKLFRRFWRGDN--SRHSVGQGLGLSLVKAIAELHGG 431
Cdd:NF033092 527 DQGLGIpkKDLDKIFDRFYRVDKarSRKMGGTGLGLAIAKEVVEAHGG 574
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
234-297 |
8.65e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.22 E-value: 8.65e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749551 234 ERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLAR 297
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
243-432 |
1.81e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 63.17 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 243 LAHELRTPINAL-----LGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENilFLARADknnvlVKLDSLSLNKEVE 317
Cdd:COG4192 440 LAHELNQPLNAMsmylfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQ--FSRKSD-----TPLQPVDLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 318 NLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILItSFLDTNGSLNIDIASPGTKINEPE 397
Cdd:COG4192 513 QAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISV-DLLSNAENLRVAISDNGNGWPLVD 591
|
170 180 190
....*....|....*....|....*....|....*
gi 446749551 398 KLFRRFwrgdNSRHSVGQGLGLSLVKAIAELHGGS 432
Cdd:COG4192 592 KLFTPF----TTTKEVGLGLGLSICRSIMQQFGGD 622
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-448 |
4.31e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 57.14 E-value: 4.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 334 FKVECN---QQIFA--DKILLQRMLSNLIVNAIRYSPEkSRILITSFLDTNGSLNIDIASPGTKINEP--EKLFRRFWRG 406
Cdd:cd16947 1 FQVEINipdRPIYAnaNTEALQRILKNLISNAIKYGSD-GKFLGMTLREDEKHVYIDIWDKGKGISETekDHVFERLYTL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446749551 407 DNSRHSV--GQGLGLSLVKAIAELHGGSATYH-YLNKLNVFRITL 448
Cdd:cd16947 80 EDSRNSAkqGNGLGLTITKRLAESMGGSIYVNsKPYEKTVFTVTL 124
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
3.14e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.50 E-value: 3.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPEKSRILITSFLDTNGSLNIDIAS--PGTKINEPEKLFRRFWRGDNSRHSVGQ--GLGLSLVKA 424
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDegPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQ 80
|
90
....*....|
gi 446749551 425 IAELHGGSAT 434
Cdd:cd16953 81 IIEAHGGISV 90
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
227-449 |
3.47e-09 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 58.32 E-value: 3.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 227 QALVKDFERLSQFADDL---AHELRTPINALLGqnqvtLSQTrsiaeyqktiaGNIEELEN-ISRLTENIlflaradkNN 302
Cdd:COG3290 177 ERLEEELEGVKELAEALraqRHDFRNHLHTISG-----LLQL-----------GEYDEALEyIDEISEEL--------QE 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 303 VLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKI---LLQRMLSNLIVNAIRY---SPEKSRILITSFL 376
Cdd:COG3290 233 LIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLsdtDLVTILGNLLDNAIEAvekLPEEERRVELSIR 312
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749551 377 DTNGSLNIDIASPGTKINePEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHYL-NKLNVFRITLP 449
Cdd:COG3290 313 DDGDELVIEVEDSGPGIP-EELLEKIFERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEeGEGTVFTVRLP 385
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
234-449 |
4.04e-09 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 58.45 E-value: 4.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 234 ERLS---QFADDLAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGNI-EELENISRLTENILFLARADKnnvlVKLDS 309
Cdd:COG5809 265 EKLSvvgELAAGIAHEIRNPLTSLKGFIQLLKD---TIDEEQKTYLDIMlSELDRIESIISEFLVLAKPQA----IKYEP 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 310 LSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNGSLNIDI 386
Cdd:COG5809 338 KDLNTLIEEVIPLLQPQALLKNVQIELELEDDipdILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVVISV 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446749551 387 ASPGTKINEP--EKLFRRFWrgdnSRHSVGQGLGLSLVKAIAELHGGSATYHY-LNKLNVFRITLP 449
Cdd:COG5809 418 TDEGCGIPEErlKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKITVESeVGKGTTFSITLP 479
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
349-432 |
4.33e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 54.04 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPE---KSRILITSFLDTNGSLNIDIASPGTKINEPE--KLFRRFWRGDNS--RHSVGQGLGLSL 421
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEgevTLRVSLEEEEEDGVQLRFSVEDTGIGIPEEQqaRLFEPFSQADSSttRKYGGTGLGLAI 80
|
90
....*....|.
gi 446749551 422 VKAIAELHGGS 432
Cdd:cd16922 81 SKKLVELMGGD 91
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
237-449 |
5.27e-09 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 58.59 E-value: 5.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 237 SQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEV 316
Cdd:PRK09959 713 SQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLV 792
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 317 ENLLDYLEYLSDEKEICfkVECNQQiFADKILL-------QRMLSNLIVNAIRYSPEKSRILITSFL---DTNGSLNIDI 386
Cdd:PRK09959 793 QNTCHSFGAIAASKSIA--LSCSST-FPDHYLVkidpqafKQVLSNLLSNALKFTTEGAVKITTSLGhidDNHAVIKMTI 869
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446749551 387 ASPGTKINEPE--KLFRRFWRGDNSRHSVGQGLGLSLVKA-IAELHGGSATYHYLNKLNVFRITLP 449
Cdd:PRK09959 870 MDSGSGLSQEEqqQLFKRYSQTSAGRQQTGSGLGLMICKElIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-434 |
6.26e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 53.23 E-value: 6.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 345 DKILLQRMLSNLIVNAIRYSPEKSRILITSFLDTNGsLNIDIASPGTKINE--PEKLFRRFW---RGDNSRHSvgQGLGL 419
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEG-IELLVFDEGSGIPDyaLNRVFERFYslpRPHSGQKS--TGLGL 77
|
90
....*....|....*
gi 446749551 420 SLVKAIAELHGGSAT 434
Cdd:cd16945 78 AFVQEVAQLHGGRIT 92
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
235-299 |
6.44e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 52.21 E-value: 6.44e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446749551 235 RLSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARAD 299
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-435 |
9.15e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 53.79 E-value: 9.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 314 KEVENLLDYLEYLSDEK--EICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEksRILITSFLDTNGS-LNIDIASPG 390
Cdd:cd16954 1 PLLDSLCSALNKVYQRKgvSISLDISPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLhLIVDDDGPG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446749551 391 TKINEPEKLFRRFWRGDNSRHsvGQGLGLSLVKAIAELHGGSATY 435
Cdd:cd16954 79 VPESQRSKIFQRGQRLDEQRP--GQGLGLAIAKEIVEQYGGELSL 121
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
235-299 |
4.44e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.87 E-value: 4.44e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446749551 235 RLSQFADDLAHELRTPINALLGQNQVTLSQTRSiAEYQKTIAGNIEELENISRLTENILFLARAD 299
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-429 |
5.97e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 50.66 E-value: 5.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPEKSRILITSFLDTNGS-LNIDIASPGTKINEPEKLFRRFWRGD--NSRHSVGQGLGLSLVKAI 425
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGArLSVEDTGPGIPPEHIPRLTERFYRVDieRCRNTGGTGLGLAIVKHV 80
|
....
gi 446749551 426 AELH 429
Cdd:cd16952 81 MSRH 84
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
223-449 |
1.48e-07 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 53.58 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 223 NKMHQALVKDFERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIagnIEELENISRLTENILFLARaD 299
Cdd:COG5805 271 KKEAEELMARSEKLSiagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIM---LSELDRIESIISEFLALAK-P 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 300 KNNVLVKLDSLSLNKEVENLLdYLEYLSDEKEICFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRILITSFLDT 378
Cdd:COG5805 347 QAVNKEKENINELIQDVVTLL-ETEAILHNIQIRLELlDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEED 425
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749551 379 NgSLNIDIASPGTKINEP--EKLFRRFWrgdnSRHSVGQGLGLSLVKAIAELHGGSATY-HYLNKLNVFRITLP 449
Cdd:COG5805 426 N-SVIIRVIDEGIGIPEErlKKLGEPFF----TTKEKGTGLGLMVSYKIIENHNGTIDIdSKVGKGTTFTITLP 494
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
184-432 |
7.22e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 51.56 E-value: 7.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 184 LREIKKLSGVTEALNyNDNREPVEVSAlPRELKPLGQALNKMhqaLVKDFERLSQFA---DDLAHELRTPINALlgqnQV 260
Cdd:PRK10815 216 LRPIEALAKQVRELE-EGEREQLDPNP-PRELTSLVRNLNRL---LKNERERYTKYRttlTDLTHSLKTPLAVL----QS 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 261 TLsqtRSIAEYQKTiagNIEE-----LENISRLTENI-LFLARAD---KNNVLVK--------LDSL--SLNK-----EV 316
Cdd:PRK10815 287 TL---RSLRSGKQM---SVEQaepimLEQISRISQQIgYYLHRASmrsEHNLLSRelhsvaplLDNLtsALNKvyqrkGV 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 317 ENLLDYleylsdEKEICFKVECNQqifadkilLQRMLSNLIVNAIRYSPEKSRIlitSFLDTNGSLNI--DIASPGTKIN 394
Cdd:PRK10815 361 NITLDI------SPEITFVGEKND--------FMEVMGNVLDNACKYCLEFVEI---SARQTDEHLHIvvEDDGPGIPES 423
|
250 260 270
....*....|....*....|....*....|....*...
gi 446749551 395 EPEKLFRRFWRGDNSRHsvGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10815 424 KRELIFDRGQRADTLRP--GQGLGLSVAREITEQYEGK 459
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
2.29e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 45.85 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIR----YSPEKSRILITSFLDTNGSLNIDI--ASPGTKINEPEKLFRRFWrgdnSRHSVGQGLGLSLV 422
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVTISVkdTGPGIAEEVAGQLFDPFY----TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 446749551 423 KAIAELHGGSATYHYLNKLN-VFRITLP 449
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGaTFQFTLP 104
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
239-431 |
2.63e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 49.94 E-value: 2.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 239 FADDLAHELRTPINALLGQNQVTLsQTRSIAE---YQKTIAGNIEELENIsrlTENILFLARADKNNvlVKLDSLSLNke 315
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILL-DTELTAEqrkYLKTIHVSAITLGNI---FNDIIDMDKMERRK--LQLDNQPID-- 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 316 VENLLDYLEYLS----DEKEICFKVECN----QQIFADKILLQRMLSNLIVNAIRYSpEKSRILITSFLDTNGSLNIDIA 387
Cdd:PRK11091 358 FTDFLADLENLSglqaEQKGLRFDLEPLlplpHKVITDGTRLRQILWNLISNAVKFT-QQGGVTVRVRYEEGDMLTFEVE 436
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 446749551 388 SPGTKI--NEPEKLFRRFWR---GDNSRHSVGQGLGLSLVKAIAELHGG 431
Cdd:PRK11091 437 DSGIGIpeDELDKIFAMYYQvkdSHGGKPATGTGIGLAVSKRLAQAMGG 485
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
237-449 |
3.20e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.85 E-value: 3.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 237 SQFADDLAHELRTPINALLG------QNQVTLSQTrsiaEYQKTI---AGN----IEELENISRL------TENILFLAR 297
Cdd:PRK11107 294 SEFLANMSHELRTPLNGVIGftrqtlKTPLTPTQR----DYLQTIersANNllaiINDILDFSKLeagklvLENIPFSLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 298 AdknnvlvkldslSLNkEVENLldyLEYLSDEKEICFKVECNQQI----FADKILLQRMLSNLIVNAIRYSPEKS---RI 370
Cdd:PRK11107 370 E------------TLD-EVVTL---LAHSAHEKGLELTLNIDPDVpdnvIGDPLRLQQIITNLVGNAIKFTESGNidiLV 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 371 LITSFLDTNGSLNIDIASPGTKINEP--EKLFRRFWRGDNS---RHSvGQGLGLSLVKAIAELHGGSATYHY-LNKLNVF 444
Cdd:PRK11107 434 ELRALSNTKVQLEVQIRDTGIGISERqqSQLFQAFRQADASisrRHG-GTGLGLVITQKLVNEMGGDISFHSqPNRGSTF 512
|
....*
gi 446749551 445 RITLP 449
Cdd:PRK11107 513 WFHLP 517
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
4.05e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 45.40 E-value: 4.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 349 LQRMLSNLIVNAIRYSPEK--SRILITSFLDTNGSLnIDIASPGTKINEP--EKLFRRFWRGDNSRHSVGQGLGLSLVKA 424
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWT-FYVRDNGIGIDPEyaEKVFGIFQRLHSREEYEGTGVGLAIVRK 79
|
90
....*....|
gi 446749551 425 IAELHGGSAT 434
Cdd:cd16921 80 IIERHGGRIW 89
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-449 |
4.13e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 45.35 E-value: 4.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 345 DKILLQRMLSNLIVNAIRYSPEKSRILITSFlDTNGSLNIDIASPGTKINEPE--KLFRRFWRGDNSRHSV-GQGLGLSL 421
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDlpRVFDKGFTGENGRNFQeSTGMGLYL 80
|
90 100 110
....*....|....*....|....*....|
gi 446749551 422 VKAIAE--LHGGSATYHYlNKLNVFRITLP 449
Cdd:cd16948 81 VKKLCDklGHKIDVESEV-GEGTTFTITFP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
176-451 |
1.68e-05 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 47.21 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 176 SPLLIRTGLREIKKLSGVTEALNYND---NREPVEVSALPRELKPLGQALNKMHQALVKDFERLSQ----FADDLAHELR 248
Cdd:PRK11466 377 SPFPETAGVRELDTIGRLMDAFRSNVhalNRHREQLAAQVKARTAELQELVIEHRQARAEAEKASQaksaFLAAMSHEIR 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 249 TPINALLGQNQVTLSQTRSIA--EYQKTIAGNIEELENIsrLTENILFLA-RADKNNVLVKLDSLSLNKEVENLLDYLEY 325
Cdd:PRK11466 457 TPLYGILGTAQLLADNPALNAqrDDLRAITDSGESLLTI--LNDILDYSAiEAGGKNVSVSDEPFEPRPLLESTLQLMSG 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 326 LSDEKEICFKVECNQQIFA----DKILLQRMLSNLIVNAIRYSpEKSRILITSFLDTNGSLnIDIASPGTKINEPEK--L 399
Cdd:PRK11466 535 RVKGRPIRLATDIADDLPTalmgDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWL-VEVEDSGCGIDPAKLaeI 612
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 446749551 400 FRRFWRGDNSRHsvGQGLGLSLVKAIAELHGGSATY-HYLNKLNVFRITLPQR 451
Cdd:PRK11466 613 FQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSAtSTPEVGSCFCLRLPLR 663
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-434 |
3.89e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 42.66 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 352 MLSNLIVNAI----RYSPEKSRILItSFLDTNGSLNIDIASPGTKInEPEKLFRRFWRGDNSRHSVGQGLGLSLVKAIAE 427
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEV-FLRDEGDDLVIEVRDTGPGI-APELRDKVFERGVSTKGQGERGIGLALVRQSVE 81
|
....*..
gi 446749551 428 LHGGSAT 434
Cdd:cd16915 82 RLGGSIT 88
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-449 |
6.23e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 42.02 E-value: 6.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 348 LLQRMLSNLIVNAIRYSPEKSRILITSFLDTNgSLNIDIASPGTKInEPE---KLFRRFWrgdnSRHSVGQG--LGLSLV 422
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVD-QVLIEVEDTGSGI-DPEilgRIFDPFF----TTKPVGEGtgLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 446749551 423 KAIAELHGGS-ATYHYLNKLNVFRITLP 449
Cdd:cd16943 77 YRIIQKHGGTiRVASVPGGGTRFTIILP 104
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
227-449 |
6.29e-05 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 45.16 E-value: 6.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 227 QALVKDFERLS---QFADDLAHELRTPinallgqnqvtLSQTRSIAEY--QKTIAGN---------IEELENISRLTENI 292
Cdd:PRK10364 225 QDEMKRKEKLValgHLAAGVAHEIRNP-----------LSSIKGLAKYfaERAPAGGeahqlaqvmAKEADRLNRVVSEL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 293 LFLARADKnnvlVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSR 369
Cdd:PRK10364 294 LELVKPTH----LALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTlpeIQADPDRLTQVLLNLYLNAIQAIGQHGV 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 370 ILITSFLDTNGsLNIDIASPGTKI--NEPEKLFRRFWRGDNSrhsvGQGLGLSLVKAIAELHGGSATYHYL-NKLNVFRI 446
Cdd:PRK10364 370 ISVTASESGAG-VKISVTDSGKGIaaDQLEAIFTPYFTTKAE----GTGLGLAVVHNIVEQHGGTIQVASQeGKGATFTL 444
|
...
gi 446749551 447 TLP 449
Cdd:PRK10364 445 WLP 447
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
3-449 |
9.57e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 41.54 E-value: 9.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 3 RLSITVRLTLLFILVLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDILII 82
Cdd:COG2972 1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 83 HGDSINKIVNRTNVSDDMLNNIPATETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSI 162
Cdd:COG2972 81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 163 IICIVAIILCSVLSPLLIRTGLREIKKLSGVTEALnYNDNREPVEVSAlPRELKPLGQALNKMH---QALVKDFERLSQf 239
Cdd:COG2972 161 LIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKV-EKGDLVRLEVSG-NDEIGILARSFNEMVeriKELIEEVYELEL- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 240 addLAHELRtpINALlgQNQV-------TLSQTRSIAEyqktiagnIEELENISRLTENILFLARA--DKNNVLVkldsl 310
Cdd:COG2972 238 ---EKKEAE--LKAL--QAQInphflfnTLNSIRWLAE--------LEDPEEAEEMLEALSKLLRYslSKGDELV----- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 311 SLNKEVENLLDYLE-----YlsdEKEICFKVECNQQIfADKILLQRMLSNLIVNAIRY----SPEKSRILITSFLDtNGS 381
Cdd:COG2972 298 TLEEELELIKSYLEiqklrF---GDRLEVEIEIDEEL-LDLLIPKLILQPLVENAIEHgiepKEGGGTIRISIRKE-GDR 372
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446749551 382 LNIDIASPGTKINEP--EKLFRRFwrgdnSRHSVGQGLGLSLVKAIAELH-GGSATYHYLNKLNVF---RITLP 449
Cdd:COG2972 373 LVITVEDNGVGMPEEklEKLLEEL-----SSKGEGRGIGLRNVRERLKLYyGEEYGLEIESEPGEGttvTIRIP 441
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
222-361 |
3.68e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 39.92 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749551 222 LNKMHQALVKDFERLSQFADDLAHELRTPINALlGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKN 301
Cdd:PRK10618 436 LQQAQREYEKNQQARKAFLQNIGDELKQPLQSL-AQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQ 514
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446749551 302 NVLVKLDSLSLNKEVENLLdyLEYLSDEKE------ICFKVECNQQIFADKILLQRMLSNLIVNAI 361
Cdd:PRK10618 515 DWKPEQELFSLQDLIDEVL--PEVLPAIKRkglqllIHNHLKAEQLRIGDRDALRKILLLLLNYAI 578
|
|
| |
