MULTISPECIES: AbrB/MazE/SpoVT family DNA-binding domain-containing protein [Bacillus]
Protein Classification
AbrB/MazE/SpoVT family DNA-binding domain-containing protein( domain architecture ID 14304933)
AbrB/MazE/SpoVT family DNA-binding domain-containing protein similar to Bacillus subtilis transition state regulatory protein AbrB and Mycobacterium tuberculosis antitoxin VapB27, the antitoxin component of a type II toxin-antitoxin system whose cognate toxin is VapC27
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| AbrB_C | pfam18277 | AbrB C-terminal domain; This is the C-terminal domain of AbrB protein from Bacillus subtilis. ... |
53-89 | 3.77e-14 | ||
AbrB C-terminal domain; This is the C-terminal domain of AbrB protein from Bacillus subtilis. AbrB is a transition state regulator. Functions of AbrB include biofilm formation, antibiotic production, competence development, extracellular enzyme production, motility, and sporulation. The C-terminal domain is responsible for multimerization and, to a lesser extent than the N-terminal domain, also contributes in DNA binding. : Pssm-ID: 436380 Cd Length: 37 Bit Score: 60.40 E-value: 3.77e-14
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| SpoVT_C super family | cl46296 | Stage V sporulation protein T C-terminal, transcription factor; SpoVT_C is the C-terminal part ... |
1-48 | 2.22e-13 | ||
Stage V sporulation protein T C-terminal, transcription factor; SpoVT_C is the C-terminal part of the stage V sporulation protein T, a transcription factor involved in endospore formation in Gram-positive bacteria such as Bacillus subtilis. Sporulation is induced by conditions of environmental stress to protect the genome. SpoVT behaves as a tetramer that shows an overall significant distortion mediated by electrostatic interactions. Two monomers dimerize via the highly charged N-terminal AbrB-like domains, family pfam04014, to form swapped-hairpin beta-barrels. These asymmetric dimers then form tetramers through the formation of mixed helix bundles between their C-terminal domains. The C-termini themselves fold as GAF (cGMP-specific and cGMP-stimulated phosphodiesterases, Anabaena adenylate cyclases, and Escherichia coli FhlA) domains. The actual alignment was detected with superfamily member COG5845: Pssm-ID: 480636 Cd Length: 180 Bit Score: 61.72 E-value: 2.22e-13
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| Name | Accession | Description | Interval | E-value | ||
| AbrB_C | pfam18277 | AbrB C-terminal domain; This is the C-terminal domain of AbrB protein from Bacillus subtilis. ... |
53-89 | 3.77e-14 | ||
AbrB C-terminal domain; This is the C-terminal domain of AbrB protein from Bacillus subtilis. AbrB is a transition state regulator. Functions of AbrB include biofilm formation, antibiotic production, competence development, extracellular enzyme production, motility, and sporulation. The C-terminal domain is responsible for multimerization and, to a lesser extent than the N-terminal domain, also contributes in DNA binding. Pssm-ID: 436380 Cd Length: 37 Bit Score: 60.40 E-value: 3.77e-14
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| SpoVT | COG5845 | Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell ... |
1-48 | 2.22e-13 | ||
Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell cycle control, cell division, chromosome partitioning, Transcription]; Pssm-ID: 444547 Cd Length: 180 Bit Score: 61.72 E-value: 2.22e-13
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| MazE_antitoxin | pfam04014 | Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins ... |
8-50 | 2.65e-09 | ||
Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are also found on chromosomes and to be associated with a number of biological functions such as: reduction of protein synthesis, gene regulation and retardation of cell growth under nutritional stress. This family includes proteins from a number of different pairings, eg MazE, AbrB, VapB, PhoU, PemI-like and SpoVT. MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation, and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules. Pssm-ID: 397909 [Multi-domain] Cd Length: 44 Bit Score: 48.28 E-value: 2.65e-09
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| SpoVT_AbrB | smart00966 | SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of ... |
8-47 | 4.11e-08 | ||
SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins. Pssm-ID: 198034 [Multi-domain] Cd Length: 45 Bit Score: 45.19 E-value: 4.11e-08
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| lp_hng_hel_AbrB | TIGR01439 | looped-hinge helix DNA binding domain, AbrB family; This DNA-binding domain family includes ... |
8-48 | 1.60e-05 | ||
looped-hinge helix DNA binding domain, AbrB family; This DNA-binding domain family includes AbrB, a transition state regulator in Bacillus subtilis, whose DNA-binding domain structure in solution was determined by NMR. The domain binds DNA as a dimer in what is termed a looped-hinge helix fold. Some members of the family have two copies of the domain in tandem. The domain is found usually at the N-terminus of a small protein. This model excludes members of family TIGR02609. [Regulatory functions, DNA interactions] Pssm-ID: 273625 [Multi-domain] Cd Length: 43 Bit Score: 38.39 E-value: 1.60e-05
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| Name | Accession | Description | Interval | E-value | ||
| AbrB_C | pfam18277 | AbrB C-terminal domain; This is the C-terminal domain of AbrB protein from Bacillus subtilis. ... |
53-89 | 3.77e-14 | ||
AbrB C-terminal domain; This is the C-terminal domain of AbrB protein from Bacillus subtilis. AbrB is a transition state regulator. Functions of AbrB include biofilm formation, antibiotic production, competence development, extracellular enzyme production, motility, and sporulation. The C-terminal domain is responsible for multimerization and, to a lesser extent than the N-terminal domain, also contributes in DNA binding. Pssm-ID: 436380 Cd Length: 37 Bit Score: 60.40 E-value: 3.77e-14
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| SpoVT | COG5845 | Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell ... |
1-48 | 2.22e-13 | ||
Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression [Cell cycle control, cell division, chromosome partitioning, Transcription]; Pssm-ID: 444547 Cd Length: 180 Bit Score: 61.72 E-value: 2.22e-13
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| AbrB | COG2002 | Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene ... |
6-51 | 3.13e-12 | ||
Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module [Transcription, Defense mechanisms]; Pssm-ID: 441605 [Multi-domain] Cd Length: 70 Bit Score: 56.14 E-value: 3.13e-12
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| MazE_antitoxin | pfam04014 | Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins ... |
8-50 | 2.65e-09 | ||
Antidote-toxin recognition MazE, bacterial antitoxin; AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are also found on chromosomes and to be associated with a number of biological functions such as: reduction of protein synthesis, gene regulation and retardation of cell growth under nutritional stress. This family includes proteins from a number of different pairings, eg MazE, AbrB, VapB, PhoU, PemI-like and SpoVT. MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation, and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules. Pssm-ID: 397909 [Multi-domain] Cd Length: 44 Bit Score: 48.28 E-value: 2.65e-09
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| SpoVT_AbrB | smart00966 | SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of ... |
8-47 | 4.11e-08 | ||
SpoVT / AbrB like domain; This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins. Pssm-ID: 198034 [Multi-domain] Cd Length: 45 Bit Score: 45.19 E-value: 4.11e-08
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| lp_hng_hel_AbrB | TIGR01439 | looped-hinge helix DNA binding domain, AbrB family; This DNA-binding domain family includes ... |
8-48 | 1.60e-05 | ||
looped-hinge helix DNA binding domain, AbrB family; This DNA-binding domain family includes AbrB, a transition state regulator in Bacillus subtilis, whose DNA-binding domain structure in solution was determined by NMR. The domain binds DNA as a dimer in what is termed a looped-hinge helix fold. Some members of the family have two copies of the domain in tandem. The domain is found usually at the N-terminus of a small protein. This model excludes members of family TIGR02609. [Regulatory functions, DNA interactions] Pssm-ID: 273625 [Multi-domain] Cd Length: 43 Bit Score: 38.39 E-value: 1.60e-05
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| MazE | COG2336 | Antitoxin component MazE of the MazEF toxin-antitoxin module [Defense mechanisms]; |
16-50 | 4.22e-05 | ||
Antitoxin component MazE of the MazEF toxin-antitoxin module [Defense mechanisms]; Pssm-ID: 441907 Cd Length: 80 Bit Score: 38.33 E-value: 4.22e-05
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