|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
25-461 |
8.97e-120 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 357.15 E-value: 8.97e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 25 WKSMSMFLVPLLLSNILQSVGQLFGMVVVGRWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKA 104
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 105 IVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIV 184
Cdd:cd13138 82 AVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVII 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 185 STVLNIILLPILifgwLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLDeavRKYLRMDLDLLKLLLRLGIPA 264
Cdd:cd13138 162 ACVLNIILDLLF----IAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLS---LKDFRFDKEILKEILKIGLPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 265 SINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYII 344
Cdd:cd13138 235 ALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLII 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 345 GGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYY 424
Cdd:cd13138 315 GLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYL 394
|
410 420 430
....*....|....*....|....*....|....*..
gi 446765267 425 LSYHTNLGIKGIWIGYPAAFIVSLFLQYGYYKLSWRK 461
Cdd:cd13138 395 LSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
20-454 |
5.66e-89 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 277.80 E-value: 5.66e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 20 GKKATWKSMSMFLVPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNE 99
Cdd:COG0534 2 TEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGR-LGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 100 DRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPF 179
Cdd:COG0534 81 EEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 180 YFLIVSTVLNIILLPILIFGwlgiPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLDeavRKYLRMDLDLLKLLLR 259
Cdd:COG0534 161 IIMLIGNVLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLR---LRDLRPDRKILKRILR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 260 LGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIV 339
Cdd:COG0534 234 IGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 340 MNYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEV 419
Cdd:COG0534 314 LALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRL 393
|
410 420 430
....*....|....*....|....*....|....*
gi 446765267 420 PVAYYLSyHTNLGIKGIWIGYPAAFIVSLFLQYGY 454
Cdd:COG0534 394 PLAYLLA-FLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-461 |
8.99e-79 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 252.11 E-value: 8.99e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd13142 18 WPIIVSNLLQVAYNLADTFWLGR-LGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIM-RFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNII 191
Cdd:cd13142 97 VIILSLILAVLGYILSRPLLlLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFGSVLLNVI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 192 LLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLDeavRKYLRMDLDLLKLLLRLGIPASINMILV 271
Cdd:cd13142 177 LDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKIS---LRDLKPDWEWLKKIFRIGLPSSIEQSAR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 272 SLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAF 351
Cdd:cd13142 254 ALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 352 IYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHTNL 431
Cdd:cd13142 334 AFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGL 413
|
410 420 430
....*....|....*....|....*....|.
gi 446765267 432 GIKGIWIGYPAAFIVSLFLQYGYYKL-SWRK 461
Cdd:cd13142 414 GVTGIWIAMAISNIVAALIALAWFKRgTWKK 444
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-456 |
3.45e-75 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 242.42 E-value: 3.45e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd13137 8 WPVILENLLQTLVGLVDVFMVGR-LGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIIL 192
Cdd:cd13137 87 ALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 193 LPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLdeaVRKYLRMDLDLLKLLLRLGIPASINMILVS 272
Cdd:cd13137 167 DYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKI---SFKGFRLDRKIIKKLLRIGLPAGLEQLLRS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 273 LSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFI 352
Cdd:cd13137 244 LGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 353 YLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHTNLG 432
Cdd:cd13137 324 FIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVLGLG 403
|
410 420
....*....|....*....|....
gi 446765267 433 IKGIWIGYPAAFIVSLFLQYGYYK 456
Cdd:cd13137 404 LTGIWLAMFVDTIVRAILLLYRFR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
34-381 |
1.52e-65 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 214.42 E-value: 1.52e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 34 PLLLSNILQSVGQLFGMVVVGRWLGMnELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTFT 113
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPV-DLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 114 FIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIILL 193
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 194 PILIFGWLGIpkLGVYGAAYASVISTIVTFIVMLIYLKKKNhplNLDEAVRKYLRMDLDLLKLLLRLGIPASINMILVSL 273
Cdd:TIGR00797 160 YILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKAK---KIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 274 SEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIY 353
Cdd:TIGR00797 235 SFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILI 314
|
330 340
....*....|....*....|....*...
gi 446765267 354 LFSREILSLFLTNSNTIEIAHSLVMITL 381
Cdd:TIGR00797 315 LFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-464 |
2.37e-59 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 200.81 E-value: 2.37e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd13134 10 WPIFIELLLQMLLGTIDTFMLSR-YSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIIL 192
Cdd:cd13134 89 NLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 193 LPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNldeAVRKYLRMDLDLLKLLLRLGIPASINMILVS 272
Cdd:cd13134 169 NYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRF---RLKDLRPFPKKLLKKILKIGLPSAGEELSYN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 273 LSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFI 352
Cdd:cd13134 246 LSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 353 YLFSREILSLFLTNSNTIEIAHSLVMITLwsYLIFGHA--QIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHTN 430
Cdd:cd13134 326 ALFREPILGLFTDDPEIIALGKTLLLISI--LLEPGRAfnIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLGIVLG 403
|
410 420 430
....*....|....*....|....*....|....*
gi 446765267 431 LGIKGIWIGYPA-AFIVSLFLQYGYYKLSWRKKRI 464
Cdd:cd13134 404 LGLLGVWIAFAAdEWVRGIIMLWRWRSGKWIKKAL 438
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
33-456 |
3.32e-59 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 200.24 E-value: 3.32e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRWLGmNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLG-DALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIIL 192
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 193 LPILIFGWLGiPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLDeavRKYLRMDLDLLKLLLRLGIPASINMILVS 272
Cdd:cd12082 161 DPLLIFGLGP-PELGIAGAALATVISYVIGALLLLIYLRKGKKILKFK---LSLLKPDLELLRRLLRIGLPSAIQNSLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 273 LSEIAVIAFVNRF-GSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAF 351
Cdd:cd12082 237 LGLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 352 IYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAyYLSYHTNL 431
Cdd:cd12082 317 ILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA-YVLAYLGL 395
|
410 420
....*....|....*....|....*
gi 446765267 432 GIKGIWIGYPAAFIVSLFLQYGYYK 456
Cdd:cd12082 396 GLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
56-439 |
6.45e-51 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 178.56 E-value: 6.45e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 56 WLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFM 135
Cdd:cd13145 38 KISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 136 GTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIILLPILIFGWLGIPKLGVYGAAYAS 215
Cdd:cd13145 118 GAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIFGGGGIPAMGVSGIALAT 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 216 VIStivTFIVMLIYLKKKNHPLNLDEAVRKYLRMDLDLLKLLLRLGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGV 295
Cdd:cd13145 198 IIS---QFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGI 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 296 VNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHS 375
Cdd:cd13145 275 ALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAG 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446765267 376 LVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHTNLGIKGIWIG 439
Cdd:cd13145 355 YLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWG 418
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
31-450 |
1.14e-47 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 169.61 E-value: 1.14e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 31 FLVPLLLSNILQSVGQLFGMVVVGRWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTL 110
Cdd:cd13143 9 FALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFSTAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 111 TFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNI 190
Cdd:cd13143 89 LLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 191 ILLPILIFGWlgipKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLdeaVRKYLRMDLDLLKLLLRLGIPASINMIL 270
Cdd:cd13143 169 ILDPLFIFVL----GLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKL---SLLRFKLSLKIIKEILALGFPSFLMQLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 271 VSLSEIAVIAFVNRFGSEAT-AAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILI 349
Cdd:cd13143 242 SSVVTIVLNLTLLGYGGDIGvAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 350 AFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHt 429
Cdd:cd13143 322 LILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRL- 400
|
410 420
....*....|....*....|.
gi 446765267 430 nLGIKGIWIGYPAAFIVSLFL 450
Cdd:cd13143 401 -FGLDGIWLAFPLAEILTLLL 420
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
25-466 |
1.18e-47 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 169.60 E-value: 1.18e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 25 WKSMSMFLVPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKA 104
Cdd:cd13131 2 LRALLRLALPILIAQLAQMAMGFVDTVMAGR-LGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 105 IVGTTLTFTFIIGVILAIAGnVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIV 184
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLL-WLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 185 STVLNIILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLkKKNHPLNLDEAVRKYLRMDLDLLKLLLRLGIPA 264
Cdd:cd13131 160 ALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYI-RRHKRFRRYRLFARFWRPDWARLKELLRLGLPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 265 SINMilvsLSEIAVIAFVN----RFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVM 340
Cdd:cd13131 239 GLTI----FFEVSLFAAVAllmgRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 341 NYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWsYLIFGHAQIIGA-TMRASGTVLWPTIIGVVSIWLVEV 419
Cdd:cd13131 315 GVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAAL-FQLFDGIQVVAAgALRGYKDTRVPFLLALISYWGIGL 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 446765267 420 PVAYYLSYHTNLGIKGIWIGYPAAFIVSLFLqygyykLSWRKKRISR 466
Cdd:cd13131 394 PLGYLLAFTTGLGAFGVWIGLIIGLALAAIL------LLWRFRRLQR 434
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
24-456 |
3.73e-44 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 160.39 E-value: 3.73e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 24 TWKSMSMFLVPLLLSNILQSVGQLFGMVVVGrWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLK 103
Cdd:cd13133 3 GYREILKIALPLVLSMLSQTVMGFTDRAFLG-RLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 104 AIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLI 183
Cdd:cd13133 82 RVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 184 VSTVLNIILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLdeAVRKYLRMDLDLLKLLLRLGIP 263
Cdd:cd13133 162 VMVVVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRF--GLRRAWRFDRELLRRILRLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 264 ASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYI 343
Cdd:cd13133 240 SGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 344 IGGILIAFIYLFSREILSLFLTNSNTIEI---AHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVP 420
Cdd:cd13133 320 YMLLLGILFLLFPELLLSIFTPGADFALIaelAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLP 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 446765267 421 VAYYLSYHtNLGIKGIWIGYPAAFIVSLFLQYGYYK 456
Cdd:cd13133 400 PAYLLVVL-GAGLAGAWTVETVYVIVLALIFLLRFR 434
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
56-456 |
3.28e-42 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 155.08 E-value: 3.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 56 WLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFM 135
Cdd:cd13144 37 RLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 136 GTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIILLPILIFGWLGIPKLGVYGAAYAS 215
Cdd:cd13144 117 TDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILDPILIFGLFGFPAMGIAGAAIAT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 216 VISTIVTFIVMLIYLKKKNHPLNLDEAVRKylrMDLDLLKLLLRLGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGV 295
Cdd:cd13144 197 VIGQILAMFLAFFFLLRKNKDVQPDLRLFR---PSLRIIKEIYAVGLPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGI 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 296 VNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHS 375
Cdd:cd13144 274 YFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVP 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 376 LVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHtnLGIKGIWIGYPAAFIVSLFLQYGYY 455
Cdd:cd13144 354 ALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWLLAKM--FGLNGVWWSFPIAEIVSFLLSLLFL 431
|
.
gi 446765267 456 K 456
Cdd:cd13144 432 K 432
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-446 |
4.96e-42 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 155.08 E-value: 4.96e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd13139 21 IPMVLEMVMESLFAVVDLYFVSR-LGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIIL 192
Cdd:cd13139 100 GVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNIIL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 193 LPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLdeaVRKYLRMDLDLLKLLLRLGIPASINMILVS 272
Cdd:cd13139 180 DPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQI---RRRHLKLDWAIIKKIIKIAVGGILQFLIAS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 273 LSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRL-QEVIRAGiVMNYIIGGILIAF 351
Cdd:cd13139 257 SSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAeKSVWRAG-KYNMVFLGIVSLV 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 352 IYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHTNL 431
Cdd:cd13139 336 FFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNL 415
|
410
....*....|....*
gi 446765267 432 GIKGIWIGYPAAFIV 446
Cdd:cd13139 416 GPKGVFIAIPIAETV 430
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-437 |
5.44e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 149.21 E-value: 5.44e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAI--SAFFPLFFLLVSFVIGIGSGssILIGQAFGARNEDRLKAIVGTTL 110
Cdd:cd13140 12 LPIMGTSFIQMAYNLTDMFWVGR-LGSDAVAAVgtAGFFVWLAYALALLSKIGAQ--VKVSQSIGAKDEKEARKYARNAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 111 TFTFIIGVILAIAGNVFALNIMRFMG-TPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLN 189
Cdd:cd13140 89 QLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 190 IILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHplnLDEAVRKYLRMDLDLLKLLLRLGIPASINMI 269
Cdd:cd13140 169 IILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKG---LFLKIRILKRPDRKYIKEILKLGLPVALQSI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 270 LVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILI 349
Cdd:cd13140 246 LFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFAT 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 350 AFIYLFSREILSLFLTNSNTIEIAHslvmitlwSYL-IFGHAQI-----IGATMRASGT--VLWPTIIGVVsIWLVEVPV 421
Cdd:cd13140 326 LLLFFFGEPLFSLFIPDPETIAIGV--------DYLrILGFSQLfmcleITTTGAFNGLgrTKPPAIISIV-FNGLRIPL 396
|
410
....*....|....*.
gi 446765267 422 AYYLSyHTNLGIKGIW 437
Cdd:cd13140 397 ALLLS-PTGLGLNGIW 411
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
57-452 |
5.96e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 148.99 E-value: 5.96e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 57 LGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMG 136
Cdd:cd13149 39 LGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 137 TPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIILLPILIFGWLGIPKLGVYGAAYASV 216
Cdd:cd13149 119 ASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAALVNVILDPILIFGFGPIPGMGIAGAAIATV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 217 ISTIVTFIVMLIYLKKKNHPLNLDEAVRKylrMDLDLLKLLLRLGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGVV 296
Cdd:cd13149 199 ISRALGLGAALYFLHYHHRLIDFSEPSLK---ALFRSWKDILSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 297 NQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSL 376
Cdd:cd13149 276 TRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLY 355
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446765267 377 VMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHtnLGIKGIWIGYPAAFIVSLFLQY 452
Cdd:cd13149 356 LLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYVGSHL--LGFAGVFIGALAGNLIAGILAY 429
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
21-467 |
1.13e-33 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 131.51 E-value: 1.13e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 21 KKATWKsmsmFLVPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNED 100
Cdd:cd13147 8 KKAIIK----LSIPMIIAMLLQTLYNLVDAIWVAG-LGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 101 RLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTpENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFY 180
Cdd:cd13147 83 GADNAAVHSILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 181 FLIVSTVLNIILLPILIFgWLGipkLGVYGAAYASVISTIVTFIVMLIYLK-KKNHPLNLDeavRKYLRMDLDLLKLLLR 259
Cdd:cd13147 162 AMVAGSILNIILDPIFIY-TLG---LGIAGAAWATVISMLISSLVLLYWFFvKKDTYVSLS---LKNFKFDKKIVKDILK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 260 LGIPASINMILVSLSEIAVIAF-VNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGI 338
Cdd:cd13147 235 VGIPASLEQLIMSVLMIILNLIlVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 339 VMNYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLV--MITLWSYLIFGHAQIIGATM-RASGTVLWPTIIGVVSIW 415
Cdd:cd13147 315 KLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVafLRIMCLFLPFVPFGMMSSSMfQGIGKGLTSLIITILREL 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 446765267 416 LVEVPVAYYLSYHTNLGIKGIWIGYPAAFIVSLFLQYgyyklSWRKKRISRL 467
Cdd:cd13147 395 IFQVLFAYLFAIVLGLGLFGVWWGIVLGNAIGSIVGY-----LWARLYIKRL 441
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-446 |
1.61e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 128.54 E-value: 1.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIG-IGSGSSILIGQAFGARNEDRLKAIVGTTLT 111
Cdd:cd13148 19 LPNILALLVQTLVGLAETYFVGQ-LGTDALAGVALVFPLLMLTQMMSNGaMGGGVSSAIARALGAGDRERAEALVWHALV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 112 FTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNII 191
Cdd:cd13148 98 IALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGAVVQIP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 192 LLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLDeavRKYLRMDLDLLKLLLRLGIPASINMILV 271
Cdd:cd13148 178 LSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLR---LRALRLERRLFRDILRVGLLAALSPLQT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 272 SLSEIAVIAFVNRFGSEATAAYGVVNQVaSYVQMPAV-SLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIA 350
Cdd:cd13148 255 NLTVLLLTGLVGRFGTAALAGYGIGSRL-EFLLIPLVfGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAVLAGAIGL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 351 FIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIwLVEVPVAYYLSYHTN 430
Cdd:cd13148 334 VLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAGTLRL-LIAAGGGWIAVALFG 412
|
410
....*....|....*.
gi 446765267 431 LGIKGIWIGYPAAFIV 446
Cdd:cd13148 413 AGLAGLFAAAAAAMVA 428
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-456 |
9.03e-30 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 120.47 E-value: 9.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd13135 8 IPLILQNLVSQLQMLVDRAFLGR-ISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIIL 192
Cdd:cd13135 87 NSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 193 LPILIFGWLGIPKLGVYGAAYASVISTIVTFIvMLIYLKKKNHPLNLDEAVRKYLRMDLDLLKLLLRLGIPASINMILVS 272
Cdd:cd13135 167 DYVLIFGNFGFPRLGIIGAAIATTIANVLNLI-ILVYLCRKIKKLTFKLSNTKVLKANIRPYKFTIKLGLPLGGEEFLWN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 273 LSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFI 352
Cdd:cd13135 246 IGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAAIVF 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 353 YLFSREILSLFLTNSNTIEiaHSLVMITLWSYLIFGHA--QIIGATMRASGTVLWpTIIGVVSIWLVEVPVAYYLSYHTN 430
Cdd:cd13135 326 LAFPYKILSLFTNDPELIN--YSIPYLIFIIIILFFKSinIVYGFAIRAIGDTKW-MLYTQIIGTIIVVSVALLLIFVFK 402
|
410 420
....*....|....*....|....*.
gi 446765267 431 LGIKGIWIGYPAAFIVSLFLQYGYYK 456
Cdd:cd13135 403 LGLAGVYITLFIDEIIRAIINFLKYR 428
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-462 |
1.13e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 117.42 E-value: 1.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd13141 18 LPIAIGMIIQTLYFLVDLYFVGQ-LGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYariLFNSMPVLFLYFSYTTFI---RGTGDSKTPFYFLIVSTVLN 189
Cdd:cd13141 97 AAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTY---LYWFIPSLALQFILTVLGaalRGTGIVKPFMVIQILAVLLN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 190 IILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLDEAVRKylrMDLDLLKLLLRLGIPASINMI 269
Cdd:cd13141 174 IILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWR---PDLPTWKRLLKIGLPSGGEFL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 270 LVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILI 349
Cdd:cd13141 251 LTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALMLVLT 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 350 AFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVlWPTIIGVVSIWLVEVPVAYYLSYHT 429
Cdd:cd13141 331 LLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNT-WPSLLSSASRLLTFALPVIWLSAQP 409
|
410 420 430
....*....|....*....|....*....|...
gi 446765267 430 NLGIKGIWIGYPAAFIVSLFLQYGYYKLSWRKK 462
Cdd:cd13141 410 DFRIEQIWYLSVATTILQAALSLLLLRRELKKR 442
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
34-187 |
3.58e-26 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 103.80 E-value: 3.58e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 34 PLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTFT 113
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGH-LGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446765267 114 FIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTV 187
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLL 153
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
26-462 |
5.61e-24 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 103.81 E-value: 5.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 26 KSMSMFLVPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLL-VSFVIGIGSGSSILIGQAFGARNEDRLKA 104
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGH-LGKLELAAASLASSFANVTgFSILLGLASALDTLCGQAFGAKNYKLVGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 105 IVGTTLTFTFIIGVILAIAGnVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIV 184
Cdd:cd13132 82 YLQRALVILLLCCVPISLLW-LNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 185 STVLNIILLPILIFGwlgiPKLGVYGAAYASVISTIVTFIVMLIYLKKKNhplNLDEAVRKYLRMDLDLLKLLLRLGIPA 264
Cdd:cd13132 161 ALLLNILLNYLLVFV----LGLGFIGAALATSISYWLIVVLLLLYIFFSK---GHKATWGGFSREAFRGWGPFLKLAIPS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 265 SINMIL-VSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYI 343
Cdd:cd13132 234 ALMLCLeWWAFEILVLLAGLLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 344 IGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAY 423
Cdd:cd13132 314 IGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGL 393
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 446765267 424 YLSYHTNLGIKGIWIGYPAAFIVSLFLQYGY-YKLSWRKK 462
Cdd:cd13132 394 LLAFVLGLGLKGLWIGLIAGLILQAVILLLIiLRTDWDKE 433
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
263-423 |
2.63e-23 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 96.10 E-value: 2.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 263 PASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNY 342
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 343 IIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIwLVEVPVA 422
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPLN 159
|
.
gi 446765267 423 Y 423
Cdd:pfam01554 160 Y 160
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
22-466 |
3.98e-22 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 98.35 E-value: 3.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 22 KATWKSMSMFLVPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDR 101
Cdd:PRK01766 8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGG-VSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 102 LKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYF 181
Cdd:PRK01766 87 IAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 182 LIVSTVLNIILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKkNHPLNLDEAVRKYLRMDLDLLKLLLRLG 261
Cdd:PRK01766 167 GFLGLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKR-ARRFRDFRLFKGLYKPDWAVIKRLLKLG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 262 IPASINMIL-VSLSeIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVM 340
Cdd:PRK01766 246 LPIGLAIFFeVSLF-AVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 341 NYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVP 420
Cdd:PRK01766 325 GLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLP 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 446765267 421 VAYYLSYHTNLGIKGIWIGypaaFIVSLFLqyGYYKLSWRKKRISR 466
Cdd:PRK01766 405 LGYILALTDPMGPFGFWIG----LIIGLTA--AAILLLLRLRKLQR 444
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
62-452 |
1.80e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 93.23 E-value: 1.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 62 LAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENI 141
Cdd:cd13146 46 VGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 142 IDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIILLPILIFGWlgipKLGVYGAAYASVISTIV 221
Cdd:cd13146 126 LEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVF----DMGVKGAALATVLAQAI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 222 TFIVMLIYLKKKNHPLNLDEAVRKylrMDLDLLKLLLRLGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVAS 301
Cdd:cd13146 202 SLLYLLYVFLIGKSNVTIHIKLSN---ISSSVIVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQ 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 302 YVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITL 381
Cdd:cd13146 279 FILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMA 358
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446765267 382 WSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHTNLGIKGIWIGYPAAFIVSLFLQY 452
Cdd:cd13146 359 LALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALLAM 429
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
24-373 |
4.60e-20 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 92.24 E-value: 4.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 24 TWKSMSMFLVPLLLSNILQSvgqLFGMV---VVGRWLGMNELAAI---SAFFPLFFLLVSFVIgigSGSSILIGQAFGAR 97
Cdd:cd13136 1 LHREILALALPAILSNITVP---LLGLVdtaVVGHLGSAAYLGAValgTTIFNTLFWLFGFLR---MGTTGLVAQALGAG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 98 NEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKT 177
Cdd:cd13136 75 DREEAIALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 178 PFYFLIVSTVLNIILLPILIFGWlgipKLGVYGAAYASVISTIVTFIVMLIYLKKKnhpLNLDEAVRKYLRMDLDLLKLL 257
Cdd:cd13136 155 PLILQIVGNVVNIVLDPLFVFGL----GWGVAGAALATVIAQYLGALLGLWLLRRR---VRLLGKSLSRRLPSKAALKRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 258 LRLGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAG 337
Cdd:cd13136 228 FKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRL 307
|
330 340 350
....*....|....*....|....*....|....*.
gi 446765267 338 IVMNYIIGGILIAFIYLFSREILSLFLTNSNTIEIA 373
Cdd:cd13136 308 LQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALA 343
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-234 |
8.95e-14 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 72.93 E-value: 8.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 33 VPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTF 112
Cdd:cd13137 233 LPAGLEQLLRSLGFLVLLAIVAS-YGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 113 TFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYfliVSTVLNIIL 192
Cdd:cd13137 312 GVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLI---INLISMWLV 388
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 446765267 193 LPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKN 234
Cdd:cd13137 389 RLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGK 430
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
63-466 |
2.88e-12 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 68.23 E-value: 2.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 63 AAISAFFPLFFllvsfvIGIGSGSSILIGQAFGARNEDRLKAIVGTTLtftfIIGVILAIAGNVFALN---IMRFMGTPE 139
Cdd:PRK00187 52 AASYSFVSIFC------VGVIAAVGTLVAIRHGAGDIEGATRLAQAGL----WLAWLLALVAALLLWNlkpLLLLFGQAP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 140 NIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIILLPILIFGWLGIPKLGVYGAAYASVIST 219
Cdd:PRK00187 122 QNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGAVANLLLNYALIEGWFGLPKLGLMGIGLVTALVS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 220 IVTFIVMLIYLKKknHPLNLDEAVRK-YLRMDLDLLKLLLRLGIPASIN-MILVSLSEIAVIAfVNRFGSEATAAYGVVN 297
Cdd:PRK00187 202 NGMALALALYIRR--HPAYAAYPLRKgLSRPSRAALRELWRLGLPIGGTyAVEVGLFTFAALC-MGALGSTQLAAHQIAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 298 QVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFL-----TNSNTIEI 372
Cdd:PRK00187 279 QIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLdrndpAFAEIVQL 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 373 AHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEVPVAYYLSYHTNLGIKGIWIGYPAAFIVSLFLQy 452
Cdd:PRK00187 359 AVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVAL- 437
|
410
....*....|....
gi 446765267 453 gYYKLSWRKKRISR 466
Cdd:PRK00187 438 -TLAFEWKTARLLR 450
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
22-231 |
6.45e-12 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 66.96 E-value: 6.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 22 KATWKSMSMFLVPLLLSNILQSVGQLFGMVVVGRWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDR 101
Cdd:cd12082 215 LELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDR 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 102 LKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFyf 181
Cdd:cd12082 295 ARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSL-- 372
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 446765267 182 lIVSTVLNIILLPILIFgWLGIPKLGVYGAAYASVISTIVTFIVMLIYLK 231
Cdd:cd12082 373 -IVSLLSYWVVRLPLAY-VLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-231 |
1.25e-10 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 62.94 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 11 SKRLKNQQKGKKATWKSMSMFLVPLLLSNILQSVGQLFGMVVVGRWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILI 90
Cdd:cd13128 191 KILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 91 GQAFgARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIidMSVHYARILFNSMPVLFLYFSYTTFIR 170
Cdd:cd13128 271 SELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYL--PAALVLQILAWGFLFIFLNGIFGSILQ 347
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446765267 171 GTGDSKTPFYFLIVSTVLNIIllpiliFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLK 231
Cdd:cd13128 348 AIGKQKLTLKILLIGALLNVI------LNLLLIPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
25-452 |
2.54e-10 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 62.45 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 25 WKSMSMFLVPLLLSNILQSVGQLFGMVVVGrWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKA 104
Cdd:PRK10189 28 WREITPLAVPIFIENLCVLLMGVLSTFLVS-WLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 105 IVGTTLTFTFIIGVILAIAGNVFALNIMRFMG---TPEnIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYF 181
Cdd:PRK10189 107 AARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAgdaTPE-VKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLI 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 182 LIVSTVLNIILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPlNLDEAVRKYLR-MDLDLLKLLLRL 260
Cdd:PRK10189 186 NGGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNP-ALRISLKSYFKpLNFAIIWEVMGI 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 261 GIPASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAgIVM 340
Cdd:PRK10189 265 GIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRH-VFW 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 341 NYIIGGILIAFIYLFSREILSLFLTNS-NTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWLVEV 419
Cdd:PRK10189 344 LSTLGLTAIAWLSAPFAGLLASFYTQDpDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYAMWVSMLGMWGCRV 423
|
410 420 430
....*....|....*....|....*....|...
gi 446765267 420 PVAYYLSYHTNLGIKGIWIGYPAAFIVSLFLQY 452
Cdd:PRK10189 424 VAGYILGIMLGFGVVGVWMGMFLDWAVRGVLFY 456
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
262-466 |
4.60e-10 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 61.19 E-value: 4.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 262 IPASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMN 341
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 342 YIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIWL--VEV 419
Cdd:cd12082 82 ILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLniLLD 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446765267 420 PVAYYLSYHTNLGIKGIWIGYPAAFIVSLFLQYGYYKLSWRKKRISR 466
Cdd:cd12082 162 PLLIFGLGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKL 208
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-231 |
4.70e-10 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 61.37 E-value: 4.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 12 KRLKNQQKGKKATWKSMSMFLVPLLLSNILQSVGQLFGMVVVGRWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIG 91
Cdd:cd13143 212 KLSLLRFKLSLKIIKEILALGFPSFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 92 QAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRG 171
Cdd:cd13143 292 YNYGAGNYDRVKQALKLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQA 371
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 172 TGDSKTPFYFLIVSTVLNIILlpiliFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLK 231
Cdd:cd13143 372 IGKAKRAALLSLLRQGLFLIP-----LLLILPRLFGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
22-233 |
1.42e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 59.82 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 22 KATWKSMSMFLVPLLLSNILQSVGQLFGMVVVGRwLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDR 101
Cdd:cd13134 224 KKLLKKILKIGLPSAGEELSYNLSQTVITAFIAR-LGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDE 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 102 LKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYF 181
Cdd:cd13134 303 AYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLI 382
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 446765267 182 LIVSTVlniilLPILIFGW-LGIP-KLGVYGAAYASVISTIVTFIVMLIYLKKK 233
Cdd:cd13134 383 GIISMW-----GISVPLAYlLGIVlGLGLLGVWIAFAADEWVRGIIMLWRWRSG 431
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
31-227 |
1.57e-08 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 56.50 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 31 FLVPLLLSNILQSVGQLFGMVVVGRWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGARNEDRLKAIVGTTL 110
Cdd:COG2244 178 YSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKAL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 111 TFTFIIGVILAIAGNVFALNIMRFMGTPEniIDMSVHYARILFNSMPVLFLYFSYTTFIRGTGDSKTPFYFLIVSTVlni 190
Cdd:COG2244 258 RLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV--- 332
|
170 180 190
....*....|....*....|....*....|....*..
gi 446765267 191 illPILIFGWLGIPKLGVYGAAYASVISTIVTFIVML 227
Cdd:COG2244 333 ---LNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
263-466 |
1.69e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 49.94 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 263 PASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNY 342
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 343 IIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIwLVEVPVA 422
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGN-VINIILN 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 446765267 423 YYLSY--HTNLGIKGI----WIGYPAAFIVSLFLQYGYYKLSWRKKRISR 466
Cdd:TIGR00797 160 YILIFgkFGFLGIVGAalatVISYWLMFLLLLYYIKKAKKIGLKWEGLLK 209
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
12-233 |
2.11e-06 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 49.77 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 12 KRLKNQQKGKKATWKSMSMFL----VPLLLSNILQSVGQLFGMVVVGR---WLGMNELAAISAF-------FPLFFLLVS 77
Cdd:cd13124 206 KRLLRKSPRSKISTKEILKELlsyaIPITLSSLILPLLQLIDSFTVPRrlqAAGLSESEATALYgiltgraQPLVQLPTV 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 78 FVIGIGSGSSILIGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIdmsvHYARILFNSMP 157
Cdd:cd13124 286 IATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEGG----LILQILAPSIL 361
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446765267 158 VLFLYFSYTTFIRGTGDSKTPFYFLIVSTVLNIILLpilifgWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKK 233
Cdd:cd13124 362 FLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLN------YVLIPIFGIYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
81-233 |
1.07e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 47.52 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 81 GIGSGSSILIGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYARILFNSMpvLF 160
Cdd:cd13140 285 GFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQ--LF 362
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446765267 161 LYFSYTT--FIRGTGDSKTPFyflIVSTVLNIILLPILIFgwLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKK 233
Cdd:cd13140 363 MCLEITTtgAFNGLGRTKPPA---IISIVFNGLRIPLALL--LSPTGLGLNGIWWAISISSILKGIILTIWFLLY 432
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
71-244 |
2.84e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 46.30 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 71 LFFLLVSFVIGIGSGSSIL--IGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMR--FMG---TPENIID 143
Cdd:COG0728 265 RLYQLPLGLFGVAIGTALLprLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRllFERgafTAEDTAL 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 144 MsvhyARILFNSMPVLFLYFSYTTFIRG---TGDSKTPFYFLIVSTVLNIIllpiliFGWLGIPKLGVYGAAYASVISTI 220
Cdd:COG0728 345 T----ALALAAYALGLPAFALVKVLARAfyaRQDTRTPVRIAVIAVVVNIV------LNLLLVPPLGHAGLALATSLSAL 414
|
170 180
....*....|....*....|....
gi 446765267 221 VTFIVMLIYLKKKNHPLNLDEAVR 244
Cdd:COG0728 415 VNALLLLVLLRRRLGGLPLRGILR 438
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
260-468 |
3.09e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 46.35 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 260 LGIPASINMILVSLSEIAVIAFVNRF-GSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGI 338
Cdd:cd13143 9 FALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFSTAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 339 VMNYIIGGILIAFIYLFSREILSLFLTNSNTIEIAHSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSIwLVE 418
Cdd:cd13143 89 LLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGA-VLN 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 446765267 419 VPVAYYLSYHTNLGIKGIWIGYPAAFIVSLFLQYGYYklsWRKKRISRLV 468
Cdd:cd13143 168 IILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYF---FRGKSLLKLS 214
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
97-460 |
2.05e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 43.60 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 97 RNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFM--GTPENIIDMSVHYARILFnsmPVLFLYfSYTTFIRGTGD 174
Cdd:cd13123 65 EGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLapGFSGDKFELAVALTRIMF---PYLLFI-SLSALLGGILN 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 175 SKTPFYFLIVSTVLNIILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNL-----DEAVRKylrm 249
Cdd:cd13123 141 AHGRFFAPALAPVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPrldfrDPGVRR---- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 250 dldllklLLRLGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVasyVQMP----AVSLGITVSIFAAQSIGGK 325
Cdd:cd13123 217 -------VLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRL---YQLPlgifGVAIATALLPRLSRLAAAG 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 326 QFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFL-----TNSNTIEIAHSLVM--ITLWSYLIFghaQIIGATMR 398
Cdd:cd13123 287 DLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFergafTAEDTLMTASALAAyaLGLPAFALV---KLLSRAFY 363
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446765267 399 ASGTVLWPTIIGVVSIwLVEVPVAYYLSYHtnLGIKGIWIGYPAAFIVSLFLqyGYYKLSWR 460
Cdd:cd13123 364 ALKDTKTPVKIAVIAV-AVNILLNLLLIKP--LGHVGLALATSLSAWVNALL--LLVLLRRR 420
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
72-233 |
4.17e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 42.44 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 72 FFLLVSFVIGIGSGSSIL--IGQAFGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHY- 148
Cdd:cd13123 259 LYQLPLGIFGVAIATALLprLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGAFTAEDTLMt 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 149 ARILFNSMPVLFLYFSYTTFIRG---TGDSKTPFYFLIVSTVLNIIllpiliFGWLGIPKLGVYGAAYASVISTIVTFIV 225
Cdd:cd13123 339 ASALAAYALGLPAFALVKLLSRAfyaLKDTKTPVKIAVIAVAVNIL------LNLLLIKPLGHVGLALATSLSAWVNALL 412
|
....*...
gi 446765267 226 MLIYLKKK 233
Cdd:cd13123 413 LLVLLRRR 420
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
35-414 |
6.12e-04 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 42.14 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 35 LLLSNILQSVGQLFGMVVVGRWLGMNELAAISAFFPLFFLLVSFVIGIGSGSSIligqAFGARN-EDRLKAIVGTTLTFT 113
Cdd:cd13128 8 LFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALV----REIARYrKEKIREIISTSLVLK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 114 FIIGVILAIAGNVFALNIMRFMGTPENIIDMSVHYarILFNSMPVLFLYFsyttfIRGTGDSKTPFYFLIVSTVLNIILL 193
Cdd:cd13128 84 LILGILALLLLFLFAFLIAFYDPELVLLLYILALS--LPFSALNSLFRGI-----FQGFEKMKYIVIARIIESVLSLILA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 194 PILIFgwlgiPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPlnldeavRKYLRMDLDLLKLLLRLGIPASINMILVSL 273
Cdd:cd13128 157 LILVL-----LGGGLIGFALAYLIASVLSAILLLYIYRKKILL-------PKFFSFDLKLAKELLRFSIPLALSGIFSLI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 274 -SEIAVIAFVNRFGSEATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIgGKQFNRLQEVIRAGIVMNYIIGGILIAFI 352
Cdd:cd13128 225 yTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGL 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446765267 353 YLFSREILSLFLTNSNTIEIahSLVMITLWSYLIFGHAQIIGATMRASGTVLWPTIIGVVSI 414
Cdd:cd13128 304 FLFAEPIITLLFGEEYLPAA--LVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGA 363
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
53-446 |
6.80e-04 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 41.90 E-value: 6.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 53 VGRWLGMNELAAISAFFPLFFLLVSF--VIGIGSGSSILIGQafGARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALN 130
Cdd:PRK09575 39 IGHYVGAEGLAGINMAWPVIGIILGIglMVGMGTGSLLSIKR--GEGDLEKAKRILTTGLLLLLLLGPIVSVILFLFADD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 131 IMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIRgTGDSKTPFYFLIVSTVLNIILLPILIFGWLGipkLGVYG 210
Cdd:PRK09575 117 FLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLR-NDESPNLATGLMVIGALINIVLDYLFIGWLD---WGLTG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 211 AAYASVISTIVTFIVMLIYLKKKNHPLNLDEAVRKYLRMDLDLLKLLLRlgipASINMILVSlseIAVIAFVNR----FG 286
Cdd:PRK09575 193 AAIATALAQLVVTVLGLGYFFSSRANIRLTLKELRFNWSLAPKIVLLGS----SSFFMYLYG---SFVVALHNRlfmeYG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 287 SEAT-AAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFlT 365
Cdd:PRK09575 266 SALTvGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLNLFPETMIALF-N 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 366 NSNTIEIAHSLVMITLWSYLIFGHAQIIGATM-----RASGTVLWPTIigvvSIWLVEVPVAYYLSYHtnLGIKGIWIGY 440
Cdd:PRK09575 345 SGDSELIAETIVGIRLHLFAMFLDGFLVLASAyfmavNQGGKALFISI----GNMLIQLPFLFILPKW--LGVDGVWLAM 418
|
....*.
gi 446765267 441 PAAFIV 446
Cdd:PRK09575 419 PLSNIA 424
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
207-452 |
5.13e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 38.99 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 207 GVYGAAYASVISTIVTFIVMLIYLKKKNHPLNLDEAVRKYLRMDLDLLKLL-LRLGIPASINMILVSLSEIAVIAFVNRF 285
Cdd:cd13124 175 AAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEILKElLSYAIPITLSSLILPLLQLIDSFTVPRR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 286 -------GSEATAAYGVVNQVA-SYVQMP---AVSLGITVSIFAAQSIGGKQFNRLQEVIRAGIVMNYIIGGILIAFIYL 354
Cdd:cd13124 255 lqaaglsESEATALYGILTGRAqPLVQLPtviATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAV 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 355 FSREILSLFLTNSNTIEIAHSLVMITLWSYLIfghaQIIGATMRASGTVLWPTIIGVVSIwLVEVPVAYYLSYHtnLGIK 434
Cdd:cd13124 335 LAEPINTLLFGDSEGGLILQILAPSILFLSLQ----QVTAAILQGLGKVKIPVINLLIGL-LVKIVLNYVLIPI--FGIY 407
|
250
....*....|....*...
gi 446765267 435 GIWIGYPAAFIVSLFLQY 452
Cdd:cd13124 408 GAAIATVIGFLVAALLNL 425
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
96-450 |
6.32e-03 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 38.98 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 96 ARNEDRLKAIVGTTLTFTFIIGVILAIAGNVFALNIMRFM--GTPENIIDMSVHYARILFnsmPVLFLYfSYTTFIRGTG 173
Cdd:COG0728 71 KEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLapGFDPEKFALAVALTRIMF---PYILFI-GLSALLGGVL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 174 DSKTPFYFLIVSTVLNIILLPILIFGWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKKKNHPLNL-----DEAVRKylr 248
Cdd:COG0728 147 NARGRFAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPrfdlrDPGVRR--- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 249 mdldllklLLRLGIPASINMILVSLSEIAVIAFVNRFGSEATAAYGVVNQVasyVQMP----AVSLGITVSIFAAQSIGG 324
Cdd:COG0728 224 --------VLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRL---YQLPlglfGVAIGTALLPRLSRAAAA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 325 KQFNRLQEVIRAGIVMNYIIGGILIAFIYLFSREILSLFL-----TNSNTIEIAHSLVM--ITLWSYLIFghaQIIGATM 397
Cdd:COG0728 293 GDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFergafTAEDTALTALALAAyaLGLPAFALV---KVLARAF 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446765267 398 RASGTVLWPTIIGVVSIwLVEVPVAYYLSYHtnLGIKGIWIGYPAAFIVSLFL 450
Cdd:COG0728 370 YARQDTRTPVRIAVIAV-VVNIVLNLLLVPP--LGHAGLALATSLSALVNALL 419
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
19-232 |
7.15e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 38.75 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 19 KGKKATWKSMSMFLVPLLLSNILQSVGqLFGMVVVgrwLGMNELAAIsAFFPLFFLLVSFVI----GIGSGSSILIGQAF 94
Cdd:cd13144 226 RPSLRIIKEIYAVGLPSIIMQAISSVM-VFGLNKI---LAGFGPTAV-AVFGIYFKLQSFVFmpvfGLNNGLIPIVAYNY 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446765267 95 GARNEDRLKaivgTTLTFTFIIGVILAIAGNV----FALNIMRFMGTPENIIDMSVHYARILFNSMPVLFLYFSYTTFIR 170
Cdd:cd13144 301 GAGNKDRIR----EAIKYAILIAVVIMLAGGLlfqlFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQ 376
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446765267 171 GTGDsktPFYFLIVSTVLNIILLPILIfgWLGIPKLGVYGAAYASVISTIVTFIVMLIYLKK 232
Cdd:cd13144 377 ALGR---GVYSLIISVARQLVVLLPLA--WLLAKMFGLNGVWWSFPIAEIVSFLLSLLFLKR 433
|
|
| |
