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Conserved domains on  [gi|446766901|ref|WP_000844157|]
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MULTISPECIES: Uxu operon transcriptional regulator [Shigella]

Protein Classification

PRK10225 family protein( domain architecture ID 11484619)

PRK10225 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-257 0e+00

Uxu operon transcriptional regulator;


:

Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 539.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   1 MKSVTSAQRPYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80
Cdd:PRK10225   1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  81 NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH 160
Cdd:PRK10225  81 NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901 161 NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI 240
Cdd:PRK10225 161 NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI 240

                        250
                 ....*....|....*..
gi 446766901 241 YFDGYLFDSWPLDKVDA 257
Cdd:PRK10225 241 YFDGYLFDSWPLDKVDA 257
 
Name Accession Description Interval E-value
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-257 0e+00

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 539.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   1 MKSVTSAQRPYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80
Cdd:PRK10225   1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  81 NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH 160
Cdd:PRK10225  81 NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901 161 NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI 240
Cdd:PRK10225 161 NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI 240

                        250
                 ....*....|....*..
gi 446766901 241 YFDGYLFDSWPLDKVDA 257
Cdd:PRK10225 241 YFDGYLFDSWPLDKVDA 257
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
5-233 2.21e-66

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 205.55  E-value: 2.21e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   5 TSAQRPYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDS 84
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  85 -PDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASsaPGSSESGDMQFHLAIAEATHNSM 163
Cdd:COG2186   83 lALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEASGNPL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901 164 LVELFRQSWQWRENNpmwiqLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLE 233
Cdd:COG2186  161 LALLLESLRELLRRS-----VRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLRE 225
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 97-226 1.97e-24

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 94.35  E-value: 1.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901    97 ELLQARQLLESNIAEFAALQATREDIVKMRQAL-QLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQswqwr 175
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLdAMEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLES----- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 446766901   176 ennpMWIQLHSHLDDSLYR-KEWLGDHKQILAALIKKDARAAKLAMWQHLEN 226
Cdd:smart00895  76 ----LRARLRRLRRLSLEAaRRALDEHRAILDAIRARDAEAARAAMREHLEA 123
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-73 9.15e-23

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 88.06  E-value: 9.15e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446766901   10 PYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-73 5.98e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 80.57  E-value: 5.98e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446766901  11 YQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:cd07377    3 YEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
 
Name Accession Description Interval E-value
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-257 0e+00

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 539.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   1 MKSVTSAQRPYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80
Cdd:PRK10225   1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  81 NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH 160
Cdd:PRK10225  81 NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901 161 NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI 240
Cdd:PRK10225 161 NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI 240

                        250
                 ....*....|....*..
gi 446766901 241 YFDGYLFDSWPLDKVDA 257
Cdd:PRK10225 241 YFDGYLFDSWPLDKVDA 257
PRK11523 PRK11523
transcriptional regulator ExuR;
4-257 8.02e-78

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 235.51  E-value: 8.02e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   4 VTSAQRPYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTD 83
Cdd:PRK11523   3 ITEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  84 SPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMrqaLQLEERELASSAPGSSEsGDMQFHLAIAEATHNSM 163
Cdd:PRK11523  83 ADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKL---MAIQEQARGEDCFRDSE-WDLQFHVQVALATQNSA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901 164 LVELFRQSWQWRENNPMWIQLHSHLDDSLYrKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEfSNVDDIYF- 242
Cdd:PRK11523 159 LAAIVEKMWTQRSHNPYWKKLHEHIDDRTV-DNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFN-ETSDDFEFn 236

                        250
                 ....*....|....*.
gi 446766901 243 -DGYLFDSWPLDKVDA 257
Cdd:PRK11523 237 aDRYLFAENPVVHLDT 252
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
5-233 2.21e-66

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 205.55  E-value: 2.21e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   5 TSAQRPYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDS 84
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  85 -PDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASsaPGSSESGDMQFHLAIAEATHNSM 163
Cdd:COG2186   83 lALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEASGNPL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901 164 LVELFRQSWQWRENNpmwiqLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLE 233
Cdd:COG2186  161 LALLLESLRELLRRS-----VRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLRE 225
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
2-233 2.85e-36

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 128.12  E-value: 2.85e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   2 KSVTSAQRPYQEVGAMIHDLIIKtpynPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDssgshn 81
Cdd:COG1802    8 RRESLAEQVYEALREAILSGELP----PGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  82 tdsPDAnvcNDAgpFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHN 161
Cdd:COG1802   77 ---LSP---EEI--RELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGN 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446766901 162 SMLVELFRQswQWRENNPMWIQLHSHLDDslyRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLE 233
Cdd:COG1802  149 PRLAELLRR--LRARLRRYRRLSLRSPGR---LEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLE 215
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 13-234 7.82e-31

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 114.86  E-value: 7.82e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  13 EVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV---LDSSGSHNTDSPDAN- 88
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIrwrHETWSEQNIVQPLKTl 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  89 VCNDAG-PFELLQARQLLESNIAEFAALQATREDIVKMRQ---ALQLEERELASSApgssesgDMQFHLAIAEATHNSML 164
Cdd:PRK10421  86 MADDPDySFDILEARHAIEASTAWHAAMRATPGDKEKIQLcfeATLSEDPDLASQA-------DVRFHLAIAEASHNVVL 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901 165 VELFRQSWQWRENNPMWIQLHSHLDDSLYrKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEF 234
Cdd:PRK10421 159 LQTMRGFFDVLQSSVKQSRQRMYLVPPVF-SQLTEQHQAVMDAILAGDAEGARKAMMAHLSFVHTTIKRF 227
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
21-235 7.58e-27

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 104.33  E-value: 7.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  21 LIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDsPDANVCND--AGPFEL 98
Cdd:PRK09464  22 LILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSD-PLVELLSDhpESQFDL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  99 LQARQLLESNIAEFAALQATREDIVKMRQA-LQLEERELASSAPGSSESgDMQFHLAIAEATHNSMLVELFRQSWQWREN 177
Cdd:PRK09464 101 LETRHALEGIAAYYAALRGTDEDFERIREChHAIELAQQSGDLDAEANA-VMQYQIAVTEAAHNVVLLHLLRCMEPMLEQ 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446766901 178 NpmwIQLHSHLddsLYRKE----WLGDHK-QILAALIKKDARAAKLAMWQHLENVKQRLLEFS 235
Cdd:PRK09464 180 N---VRQNFEL---LYRRRemlpKVSSHRaRIFEAIVAGKPEKAREASHRHLAFIEEILLDLS 236
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 97-226 1.97e-24

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 94.35  E-value: 1.97e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901    97 ELLQARQLLESNIAEFAALQATREDIVKMRQAL-QLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQswqwr 175
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLdAMEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLES----- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 446766901   176 ennpMWIQLHSHLDDSLYR-KEWLGDHKQILAALIKKDARAAKLAMWQHLEN 226
Cdd:smart00895  76 ----LRARLRRLRRLSLEAaRRALDEHRAILDAIRARDAEAARAAMREHLEA 123
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 11-227 7.20e-23

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 93.55  E-value: 7.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  11 YQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHN--------- 81
Cdd:PRK03837  15 SEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIigqlsgmak 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  82 ---TDSPDanvcndaGPFELLQARQLLESNIAEFAALQATREDIVKMRQALqleerELASSAPGSSE---SGDMQFHLAI 155
Cdd:PRK03837  95 dflSQSPD-------GLAHLKQARLFFESSLARYAAEHATDEQIALLRKAL-----ERNSQSLGDNAafiRSDMEFHRVI 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446766901 156 AEATHNSMLVELFRQSWQW-RENNPMWIQLHSHLDDSlyrkewLGDHKQILAALIKKDARAAKLAMWQHLENV 227
Cdd:PRK03837 163 AEIPGNPIFMAIHEALLDWlIEARPEVVILHGHENVT------LQEHIAIVDAIRAHDPDEADRALQSHLNRV 229
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-73 9.15e-23

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 88.06  E-value: 9.15e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446766901   10 PYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 97-222 8.54e-21

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 84.73  E-value: 8.54e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   97 ELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWqwre 176
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLW---- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 446766901  177 nNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQ 222
Cdd:pfam07729  77 -DRLRRLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 1.12e-20

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 82.62  E-value: 1.12e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901    14 VGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-73 5.98e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 80.57  E-value: 5.98e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446766901  11 YQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:cd07377    3 YEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 14-165 4.31e-18

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 80.97  E-value: 4.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  14 VGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTdSPDANVCNdA 93
Cdd:PRK09990  12 VAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDA-SPLMHLFS-S 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  94 GP---FELLQARQLLESNIAEFAALQATREDIVKMRQALqleERELASSAPGSSESG------DMQFHLAIAEATHNSML 164
Cdd:PRK09990  90 QPrtlYDLLEVRALLEGESARLAALRGTQADFVLITRRY---EEMLAAHENNKEIDPieharlDHAFHLAICEASHNPVL 166


                 .
gi 446766901 165 V 165
Cdd:PRK09990 167 V 167
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
11-84 6.54e-15

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 71.82  E-value: 6.54e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446766901  11 YQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDS 84
Cdd:COG2188    7 YLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
10-125 4.04e-11

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 58.65  E-value: 4.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901  10 PYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTR-TVVReALIMLEIKGLVEVRRGAGIYVldssgshntdSPDAN 88
Cdd:COG1725   11 IYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPnTVAK-AYRELEDEGLIETRRGKGTFV----------AEDAR 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446766901  89 VCNDAGPFELLqaRQLLESNIAEFAALQATREDIVKM 125
Cdd:COG1725   80 ELLEERREEFL--EEALRELVAEARRLGLSLEELLEL 114
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 11-73 1.17e-09

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 57.92  E-value: 1.17e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446766901  11 YQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:COG1167   14 YLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 5-74 4.95e-06

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 46.31  E-value: 4.95e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446766901   5 TSAQRPYQEVGAMIHDLIiKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVL 74
Cdd:PRK10079   8 TSYPTRYQEIAAKLEQEL-RQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVL 76
PRK11402 PRK11402
transcriptional regulator PhoB;
6-73 2.20e-05

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 44.44  E-value: 2.20e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446766901   6 SAQRPYQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:PRK11402   6 SHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV 73
PRK09764 PRK09764
GntR family transcriptional regulator;
7-73 1.32e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 42.12  E-value: 1.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446766901   7 AQRP-YQEVGAMIHDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
Cdd:PRK09764   2 GHKPlYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
22-54 4.30e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 40.62  E-value: 4.30e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446766901  22 IIKTPYN----PGERLPPEREIAEMLDVTRTVVREAL 54
Cdd:PRK04984  16 IIESIWNnrfpPGSILPAERELSELIGVTRTTLREVL 52
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 28-70 5.88e-04

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 39.07  E-value: 5.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 446766901   28 NPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAG 70
Cdd:pfam02082  18 HPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVRGAG 60
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 37-68 4.11e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 34.80  E-value: 4.11e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 446766901   37 REIAEMLDVTRTVVREALIMLEIKGLVEVRRG 68
Cdd:pfam01978  26 DEIAEESGVPRSKVYEVLRSLEDKGLVEREKG 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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