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Conserved domains on  [gi|446772838|ref|WP_000850094|]
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MULTISPECIES: sporulation histidine kinase inhibitor Sda [Bacillus]

Protein Classification

sporulation histidine kinase inhibitor Sda( domain architecture ID 18824081)

sporulation histidine kinase inhibitor Sda mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sda COG5851
Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication ...
 6-51 1.21e-13

Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];


:

Pssm-ID: 444553  Cd Length: 46  Bit Score: 57.60  E-value: 1.21e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 446772838  6 MEQLSTELLTESYYKAKELKLNPDFILLIKQEIIRRSLEDKLVKSS 51
Cdd:COG5851   1 MKKLSDELLIESYHKAKELKLSPDFIELLEEEIQRRSLSHKLSASS 46
 
Name Accession Description Interval E-value
Sda COG5851
Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication ...
 6-51 1.21e-13

Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];


Pssm-ID: 444553  Cd Length: 46  Bit Score: 57.60  E-value: 1.21e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 446772838  6 MEQLSTELLTESYYKAKELKLNPDFILLIKQEIIRRSLEDKLVKSS 51
Cdd:COG5851   1 MKKLSDELLIESYHKAKELKLSPDFIELLEEEIQRRSLSHKLSASS 46
Sda pfam08970
Sporulation inhibitor A; Members of this protein family contain two antiparallel alpha helices ...
 6-47 3.93e-12

Sporulation inhibitor A; Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilized by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A).


Pssm-ID: 370219  Cd Length: 45  Bit Score: 53.77  E-value: 3.93e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 446772838   6 MEQLSTELLTESYYKAKELKLNPDFILLIKQEIIRRSLEDKL 47
Cdd:pfam08970  1 MKKLSDELLIEAYYKAIELNLSPDFIELIEEEIERRSLSHKI 42
 
Name Accession Description Interval E-value
Sda COG5851
Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication ...
 6-51 1.21e-13

Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];


Pssm-ID: 444553  Cd Length: 46  Bit Score: 57.60  E-value: 1.21e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 446772838  6 MEQLSTELLTESYYKAKELKLNPDFILLIKQEIIRRSLEDKLVKSS 51
Cdd:COG5851   1 MKKLSDELLIESYHKAKELKLSPDFIELLEEEIQRRSLSHKLSASS 46
Sda pfam08970
Sporulation inhibitor A; Members of this protein family contain two antiparallel alpha helices ...
 6-47 3.93e-12

Sporulation inhibitor A; Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilized by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A).


Pssm-ID: 370219  Cd Length: 45  Bit Score: 53.77  E-value: 3.93e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 446772838   6 MEQLSTELLTESYYKAKELKLNPDFILLIKQEIIRRSLEDKL 47
Cdd:pfam08970  1 MKKLSDELLIEAYYKAIELNLSPDFIELIEEEIERRSLSHKI 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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