NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446777424|ref|WP_000854680|]
View 

MULTISPECIES: type IV toxin-antitoxin system toxin YkfI [Enterobacterales]

Protein Classification

toxin( domain architecture ID 10535962)

uncharacterized toxin similar to Escherichia coli toxins YeeV, YkfI, and YpjF

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CbtA_toxin pfam06755
CbtA_toxin of type IV toxin-antitoxin system; CbtA is a family of bacterial and archaeal ...
 1-108 7.92e-79

CbtA_toxin of type IV toxin-antitoxin system; CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerization, and for MreB it inhibits its ATP-dependent polymerization. These actions of CbtA appear to occur simultaneously. he cognate antitoxin family is represented by pfam06154.


:

Pssm-ID: 369065  Cd Length: 108  Bit Score: 226.75  E-value: 7.92e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446777424    1 MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF 80
Cdd:pfam06755   1 MNTLPATHVRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFADERVIKEHIDAGITLADAVNFLVEKYELVRIDQPGF 80

                          90       100
                  ....*....|....*....|....*...
gi 446777424   81 SWQEQSPYLRAADILRARQATGLLRQSR 108
Cdd:pfam06755  81 SWQTQSPYINSIDILRARRVTGLLTRDN 108
 
Name Accession Description Interval E-value
CbtA_toxin pfam06755
CbtA_toxin of type IV toxin-antitoxin system; CbtA is a family of bacterial and archaeal ...
 1-108 7.92e-79

CbtA_toxin of type IV toxin-antitoxin system; CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerization, and for MreB it inhibits its ATP-dependent polymerization. These actions of CbtA appear to occur simultaneously. he cognate antitoxin family is represented by pfam06154.


Pssm-ID: 369065  Cd Length: 108  Bit Score: 226.75  E-value: 7.92e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446777424    1 MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF 80
Cdd:pfam06755   1 MNTLPATHVRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFADERVIKEHIDAGITLADAVNFLVEKYELVRIDQPGF 80

                          90       100
                  ....*....|....*....|....*...
gi 446777424   81 SWQEQSPYLRAADILRARQATGLLRQSR 108
Cdd:pfam06755  81 SWQTQSPYINSIDILRARRVTGLLTRDN 108
 
Name Accession Description Interval E-value
CbtA_toxin pfam06755
CbtA_toxin of type IV toxin-antitoxin system; CbtA is a family of bacterial and archaeal ...
 1-108 7.92e-79

CbtA_toxin of type IV toxin-antitoxin system; CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerization, and for MreB it inhibits its ATP-dependent polymerization. These actions of CbtA appear to occur simultaneously. he cognate antitoxin family is represented by pfam06154.


Pssm-ID: 369065  Cd Length: 108  Bit Score: 226.75  E-value: 7.92e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446777424    1 MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF 80
Cdd:pfam06755   1 MNTLPATHVRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFADERVIKEHIDAGITLADAVNFLVEKYELVRIDQPGF 80

                          90       100
                  ....*....|....*....|....*...
gi 446777424   81 SWQEQSPYLRAADILRARQATGLLRQSR 108
Cdd:pfam06755  81 SWQTQSPYINSIDILRARRVTGLLTRDN 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH