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Conserved domains on  [gi|446778895|ref|WP_000856151|]
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MULTISPECIES: oligosaccharide flippase family protein [Bacillus]

Protein Classification

MATE family efflux transporter( domain architecture ID 8282)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_like super family cl09326
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 6-401 9.38e-38

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


The actual alignment was detected with superfamily member cd13128:

Pssm-ID: 447704 [Multi-domain]  Cd Length: 402  Bit Score: 142.30  E-value: 9.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   6 ILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMREGTR-KDANISVLISSYL 84
Cdd:cd13128    1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARyRKEKIREIISTSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  85 RIRFVLAVVISVLFAIFAQFFYTDAYLRAMVYWVVLPTMFGATLQGVGMAYFQVTERMQFTAIISVLQGVTAAAALLLGM 164
Cdd:cd13128   81 VLKLILGILALLLLFLFAFLIAFYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 165 SLKWSLMTVAAMYGISSLVTGVIAFIMVLRHTTVHKGW--DKGILDQLLIF----TINGIIIMLLPQLGPIILEKVSTYE 238
Cdd:cd13128  161 LLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFsfDLKLAKELLRFsiplALSGIFSLIYTRIDTIMLGYFLGDA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 239 QVGFFGAASKIPAVLYQIPGVIAAAFYPKLFTFgNEKNIDEHRKLSQFELKLMSFLGMGISIPFIADPSFWIVTLLGEEY 318
Cdd:cd13128  241 AVGIYNAAYRIAELLLFIPSAISTALFPRISEL-YKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 319 APAGDALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGFTL 398
Cdd:cd13128  320 LPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLY 399


                 ...
gi 446778895 399 FVR 401
Cdd:cd13128  400 LLK 402
 
Name Accession Description Interval E-value
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 6-401 9.38e-38

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 142.30  E-value: 9.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   6 ILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMREGTR-KDANISVLISSYL 84
Cdd:cd13128    1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARyRKEKIREIISTSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  85 RIRFVLAVVISVLFAIFAQFFYTDAYLRAMVYWVVLPTMFGATLQGVGMAYFQVTERMQFTAIISVLQGVTAAAALLLGM 164
Cdd:cd13128   81 VLKLILGILALLLLFLFAFLIAFYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 165 SLKWSLMTVAAMYGISSLVTGVIAFIMVLRHTTVHKGW--DKGILDQLLIF----TINGIIIMLLPQLGPIILEKVSTYE 238
Cdd:cd13128  161 LLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFsfDLKLAKELLRFsiplALSGIFSLIYTRIDTIMLGYFLGDA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 239 QVGFFGAASKIPAVLYQIPGVIAAAFYPKLFTFgNEKNIDEHRKLSQFELKLMSFLGMGISIPFIADPSFWIVTLLGEEY 318
Cdd:cd13128  241 AVGIYNAAYRIAELLLFIPSAISTALFPRISEL-YKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 319 APAGDALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGFTL 398
Cdd:cd13128  320 LPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLY 399


                 ...
gi 446778895 399 FVR 401
Cdd:cd13128  400 LLK 402
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 4-396 1.24e-33

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 130.07  E-value: 1.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   4 NKILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMREGTR-KDANISVLISS 82
Cdd:COG2244    2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEyREEELRRLLST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  83 YLRIRFVLAVVISVLFAIFAQFF--YTDAYLRAMVYWVVLPTMFGATLQGVGMAYFQVTERMQFTAIISVLQGVTAAAAL 160
Cdd:COG2244   82 ALLLRLLLSLLLALLLLLLAPFIaaLLGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 161 LLGMSLKWSLMTVAAMYGISslvtgviafimvlrhttvhkgwdkgildqlliFTINGIIIMLLPQLGPIILEKVSTYEQV 240
Cdd:COG2244  162 LLLALLGLGLWGLVLKYSLP--------------------------------LLLSGLLGLLLTNLDRLLLGALLGPAAV 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 241 GFFGAASKIPAVLYQIPGVIAAAFYPKLFTFGNEKNIDEHRKLSQFELKLMSFLGMGISIPFIADPSFWIVTLLGEEYAP 320
Cdd:COG2244  210 GIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE 289

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446778895 321 AGDALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGF 396
Cdd:COG2244  290 AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLL 365
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 6-249 6.18e-07

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 50.76  E-value: 6.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895    6 ILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMRE--GTRKDANISVLISSY 83
Cdd:pfam01943   1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREiaKYREKYELVSLYWLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   84 LRIRFVLAVVISVLFAIFAQFFYTDAYLRAMVYWVVLPTMFGATLQGVGMaYFQVTERMQFTAIISVLQGVTAAAALLLG 163
Cdd:pfam01943  81 ALLVKLVLVLLFLLLPLIAAFLGLPELAVLYRILALMFLLLPGVVQFRRG-LFQGLERMKYALISQIVESLSRVILVFIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  164 MSLKWSLMTVAAMYGISSLVTGVIAFIMVLR--HTTVHKGWDKGILDQLLI---FTINGIIIMLLPQLGPIILEKVSTYE 238
Cdd:pfam01943 160 VFLPGDIVAALLYQVLAALVGGIIALAVLRKifRPRFVFPSLKLVRKLLSFgapLFISSLAISLYTYIDSILLGLLLGAG 239

                         250
                  ....*....|.
gi 446778895  239 QVGFFGAASKI 249
Cdd:pfam01943 240 AVGIYNAAYQL 250
 
Name Accession Description Interval E-value
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 6-401 9.38e-38

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 142.30  E-value: 9.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   6 ILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMREGTR-KDANISVLISSYL 84
Cdd:cd13128    1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARyRKEKIREIISTSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  85 RIRFVLAVVISVLFAIFAQFFYTDAYLRAMVYWVVLPTMFGATLQGVGMAYFQVTERMQFTAIISVLQGVTAAAALLLGM 164
Cdd:cd13128   81 VLKLILGILALLLLFLFAFLIAFYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 165 SLKWSLMTVAAMYGISSLVTGVIAFIMVLRHTTVHKGW--DKGILDQLLIF----TINGIIIMLLPQLGPIILEKVSTYE 238
Cdd:cd13128  161 LLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFsfDLKLAKELLRFsiplALSGIFSLIYTRIDTIMLGYFLGDA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 239 QVGFFGAASKIPAVLYQIPGVIAAAFYPKLFTFgNEKNIDEHRKLSQFELKLMSFLGMGISIPFIADPSFWIVTLLGEEY 318
Cdd:cd13128  241 AVGIYNAAYRIAELLLFIPSAISTALFPRISEL-YKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 319 APAGDALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGFTL 398
Cdd:cd13128  320 LPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLY 399


                 ...
gi 446778895 399 FVR 401
Cdd:cd13128  400 LLK 402
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 4-396 1.24e-33

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 130.07  E-value: 1.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   4 NKILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMREGTR-KDANISVLISS 82
Cdd:COG2244    2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEyREEELRRLLST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  83 YLRIRFVLAVVISVLFAIFAQFF--YTDAYLRAMVYWVVLPTMFGATLQGVGMAYFQVTERMQFTAIISVLQGVTAAAAL 160
Cdd:COG2244   82 ALLLRLLLSLLLALLLLLLAPFIaaLLGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 161 LLGMSLKWSLMTVAAMYGISslvtgviafimvlrhttvhkgwdkgildqlliFTINGIIIMLLPQLGPIILEKVSTYEQV 240
Cdd:COG2244  162 LLLALLGLGLWGLVLKYSLP--------------------------------LLLSGLLGLLLTNLDRLLLGALLGPAAV 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 241 GFFGAASKIPAVLYQIPGVIAAAFYPKLFTFGNEKNIDEHRKLSQFELKLMSFLGMGISIPFIADPSFWIVTLLGEEYAP 320
Cdd:COG2244  210 GIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE 289

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446778895 321 AGDALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGF 396
Cdd:COG2244  290 AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLL 365
MATE_tuaB_like cd13127
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 6-402 4.02e-17

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240532 [Multi-domain]  Cd Length: 406  Bit Score: 82.92  E-value: 4.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   6 ILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMREGTRKDAnisvLISSYLR 85
Cdd:cd13127    1 AVSGAFWSAISQVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSSALIQRKDLTEE----DLSTVFW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  86 IRFVLAVVISVLFAIFAQF---FYTDAYLRAMVYWVVLPTMFGAtLQGVGMAYFQVTERMQFTAIISVLQGVTAAAALLL 162
Cdd:cd13127   77 LNLLLGLLLYLLLFLLAPLiaaFYNEPELIPLLRVLSLSFLLSG-LGSVPRALLQRELRFKKLAIIELISTLVSGVVAIV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 163 GMSLKWSLMTVAAMYGISSLVTGVIAFIMVlrHTTVHKGWDKGILDQLLIF----TINGIIIMLLPQLGPIILEKVSTYE 238
Cdd:cd13127  156 LALLGFGVWALVAQQLVGALVSTVLLWILS--RWRPRLSFSLASLKELLSFgsklLGSNLLNYFSRNLDNLIIGKFLGAA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 239 QVGFFGAASKIPA-VLYQIPGVIAAAFYPKLFtfgneKNIDEHRKLSQFELKLMSFLGMgISIP------FIADPsfWIV 311
Cdd:cd13127  234 ALGYYSRAYRLALlPVQNITGPITRVLFPALS-----RLQDDPERLRRAYLKALRLLAL-ITFPlmvglaLLAEP--LVL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 312 TLLGEEYAPAGDALAILAFMVILQSINYPLADNLTTIGQQwKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEIT 391
Cdd:cd13127  306 LLLGEKWLPAVPILQILALAGLFQPLSSLNGSLLLALGRT-DLLLKLGLIKAVLTVLALLIGIPYGIIGVAIAYVIASLL 384

                        410
                 ....*....|.
gi 446778895 392 LLIGFTLFVRK 402
Cdd:cd13127  385 SFPLNLYLAGR 395
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 1-452 1.39e-10

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 63.26  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   1 MKTNKILKNASYLFVGNITVRFVLAIATILFARYVspGEYGM--FTTALAVSAVICYFTDAGLThtfmregtrkdANISV 78
Cdd:COG5841    1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNII--GDEGFglYQMAYPIYGLFLTLATAGIP-----------VAISK 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  79 LISSY------------LRIRFVLAVVISVLFAI--------FAQFFYTDAYLrAMVYWVVLPTMFGATLQGVGMAYFQV 138
Cdd:COG5841   68 LVAEYnalgdykgarriFRVSLLLLLILGLVFFLllffgapfIARLLLGDPRA-YYSLRALAPALLIVPVMSVLRGYFQG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 139 TERMQFTAIISVL-QGVTAAAALLLGMSLKWSLMTVAAMYGISSLVTGVIAFIMVL----------------RHTTVHKG 201
Cdd:COG5841  147 LQNMTPTAVSQVIeQIVRVIFILLLAYLLLPYGLEYAAAGATFGAVIGALAGLLVLlyyyrkrkkklkrlleKSKTKSKE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 202 WDKGILDQLLI----FTINGIIIMLLPQLGPIILEK------VSTYEQVGFFGAASKIPAVLYQIPGVIAAAFY----PK 267
Cdd:COG5841  227 SSKDILKELLRiaipITLSSLVLPLFQLIDSFTVPRrlqaagLSASEATSLYGILSGMAQPLVNLPTVLATALAtslvPA 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 268 LFTFGNEKNIDEHRKLSQFELKLMSFLGMGISIPFI--ADPsfwIVTLLgEEYAPAGDALAILAFMVILQSINYPLADNL 345
Cdd:COG5841  307 ISEAFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAvlAEP---INTLL-FGNPEGGGILAILAPSAIFLSLQQVTTGIL 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 346 TTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGFTLFVRK--GFSL-----LFKGIIFNTLAF 418
Cdd:COG5841  383 QGLGKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKytGFKLdlrrrLLKPLLASLIMG 462

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 446778895 419 ILSYILYRTILITLPP---------LIALTITGILYGIIGLAI 452
Cdd:COG5841  463 IVVLLLYRLLSLFLPEsrlgallatLIAVLVGAIVYLLLLLKL 505
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 84-402 2.63e-07

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 52.86  E-value: 2.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  84 LRIRFVLAVVISVLFAIF--------AQFFYTDAYLrAMVYWVVLPTMFGATLQGVGMAYFQVTERMQFTAIISVLQ--- 152
Cdd:cd13124   75 FRVSLILLLILGLVFFLLlffgapflAQLLLGDPRL-APVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEqiv 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 153 --GVTAAAALLLgMSLKWSLMTVAAMYGISSLVTGVIAFIMVL--------------RHTTVHKGWDKGILDQLLI---- 212
Cdd:cd13124  154 rvIVILVLAYLL-LPVGGGLYYAAAGATFGAVIGALAGLLVLLyyyrkkrrelkrllRKSPRSKISTKEILKELLSyaip 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 213 FTINGIIIMLLPQLGPIILEK------VSTYEQVGFFGAASKIPAVLYQIPGVIAAAFY----PKLFTFGNEKNIDEHRK 282
Cdd:cd13124  233 ITLSSLILPLLQLIDSFTVPRrlqaagLSESEATALYGILTGRAQPLVQLPTVIATALStslvPAISEAYAKGDKKELRR 312

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 283 LSQFELKLMSFLGMGISIPF--IADPsfwIVTLLGEeYAPAGDALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGI 360
Cdd:cd13124  313 RINQALRLTLLIGLPAAVGLavLAEP---INTLLFG-DSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLI 388

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446778895 361 GLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGFTLFVRK 402
Cdd:cd13124  389 GLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKK 430
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 6-249 6.18e-07

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 50.76  E-value: 6.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895    6 ILKNASYLFVGNITVRFVLAIATILFARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMRE--GTRKDANISVLISSY 83
Cdd:pfam01943   1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREiaKYREKYELVSLYWLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   84 LRIRFVLAVVISVLFAIFAQFFYTDAYLRAMVYWVVLPTMFGATLQGVGMaYFQVTERMQFTAIISVLQGVTAAAALLLG 163
Cdd:pfam01943  81 ALLVKLVLVLLFLLLPLIAAFLGLPELAVLYRILALMFLLLPGVVQFRRG-LFQGLERMKYALISQIVESLSRVILVFIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  164 MSLKWSLMTVAAMYGISSLVTGVIAFIMVLR--HTTVHKGWDKGILDQLLI---FTINGIIIMLLPQLGPIILEKVSTYE 238
Cdd:pfam01943 160 VFLPGDIVAALLYQVLAALVGGIIALAVLRKifRPRFVFPSLKLVRKLLSFgapLFISSLAISLYTYIDSILLGLLLGAG 239

                         250
                  ....*....|.
gi 446778895  239 QVGFFGAASKI 249
Cdd:pfam01943 240 AVGIYNAAYQL 250
Polysacc_synt_C pfam14667
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ...
 324-452 1.55e-05

Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.


Pssm-ID: 434111 [Multi-domain]  Cd Length: 141  Bit Score: 44.49  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  324 ALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAIAAILTEITLLIGFTLFVRK- 402
Cdd:pfam14667   1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRy 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446778895  403 -GFSLLFKGIIFNTLAFILSYILYRTILITLPPLIALTITGILYGIIGLAI 452
Cdd:pfam14667  81 lGLRLLLRRLLKPLLAALVMGIVVYLLLLLLGLLLGLALALLLAVLVGALV 131
Polysacc_synt_3 pfam13440
Polysaccharide biosynthesis protein;
32-321 9.82e-04

Polysaccharide biosynthesis protein;


Pssm-ID: 404342 [Multi-domain]  Cd Length: 293  Bit Score: 41.04  E-value: 9.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895   32 ARYVSPGEYGMFTTALAVSAVICYFTDAGLTHTFMREGTRKDANISVLISSYLRIRFVLAVVIsVLFAIFAQFFYTDAYL 111
Cdd:pfam13440   3 ARLLSPEDFGVVAIATVVISFANIFVDMGFSSALIQKKDITETDYSTVFTFNLIFGALIYLIL-FALAPLIASFYNQPEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  112 RAMVYWVVLPTMFGAtLQGVGMAYFQVTERMQFTAIISVL-QGVTAAAALLLGMSLK--WSLMtvaamygISSLVTGVIA 188
Cdd:pfam13440  82 VPVLRVLALVLILNG-LSSVQTALLRRDLRFKKLFKITLTsSVIGGIVGIVLAYLGFgvWALV-------IGTLAQQLLS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  189 FIMVLrHTTVHK---GWDKGILDQLLIF----TINGIIIMLLPQLGPIILEKVSTYEQVGFFGAASKIP-AVLYQIPGVI 260
Cdd:pfam13440 154 LVLLW-LASDWRprlTFSLKVIKELFSFgswlLLSNLLNYLARNLDNLIIGKVLGTAALGLYSVAYRLAlLPTANITSVI 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446778895  261 AAAFYPKLFTFGNEKniDEHRKLSQFELKLMSFLGMGISIPFIADPSFWIVTLLGEEYAPA 321
Cdd:pfam13440 233 TKVLFPALSRIQDDK--AKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLLGSQWLES 291
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 10-401 4.77e-03

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 39.23  E-value: 4.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  10 ASYLFVGNITVRFVLAIATILFARYVSPGeYGMFTTALAVSAVICYFTDAGLTHTFMREGTRKDANISVLISSYLRIRFV 89
Cdd:cd12082    1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDA-LAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  90 LAVVISVLFAIFAQFFYTDAYLRAMV-----------YWVVLPTMFGATLQGVGMAYFQVTERMQFTAIISVLQGVT--- 155
Cdd:cd12082   80 LAILLGLLLAALLLFFSPLILSLLGAeeevielaatyLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLnil 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 156 AAAALLLGMSLKWSLMTVAAMYGISSLVTGVIAFIMVLRH-----------TTVHKGWDKGILDQLLIFTINGIIIMLLP 224
Cdd:cd12082  160 LDPLLIFGLGPPELGIAGAALATVISYVIGALLLLIYLRKgkkilkfklslLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 225 QLGPIILEKVSTYEQVGFFGAASKIPAVLYQIPGVIAAAFYPKLFTFGNEKNIDEHRKLSQFELKLMSFLG--MGISIPF 302
Cdd:cd12082  240 LIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGavLGLLILL 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 303 IADPSFWIVTLLGEEYAPAGDALAILAFMVILQSINYPLADNLTTIGQQWK--RATTMGIGLAVAIISYIVLGSQFGMMG 380
Cdd:cd12082  320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKslIVSLLSYWVVRLPLAYVLAYLGLGLYG 399

                        410       420
                 ....*....|....*....|.
gi 446778895 381 AAIAAILTEITLLIGFTLFVR 401
Cdd:cd12082  400 IWLALVISLILAALVLLLFFR 420
MATE_like_10 cd13125
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 79-404 5.48e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240530 [Multi-domain]  Cd Length: 409  Bit Score: 39.06  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895  79 LISSYLRIRFVLAVVISVLFAIF----AQFFYTDAYLRAMVYWVVLpTMFGATLQGVGMAYFQVTERMQFTAIISVLQGV 154
Cdd:cd13125   75 VWSTAFRITLILSILGGLLLLLFskplSSLLFGDIDYSWVFILLGL-ALPLFALNNLLLAILNGLKEIKRYALINIISSL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 155 TAAAALLLgMSLKWSLMTVAAMYGISSLVTGVIAFIMVLR------HTTVHKgWDKGILDQLLIFTINGIIIMLLPQLGP 228
Cdd:cd13125  154 IGLLVSVL-LVYFYGLKGALLALVLNQSLIFLVTLIYSRKqpwfklKYLWGR-LDKDIIKKLLKFSLMALVSALSLPLSQ 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 229 I----ILEKVSTYEQVGFFGAASKIPAV-LYQIPGVIAAAFYPKLftFGNEKNIDEHRKLSQFELKLMSFLGMGISIPFI 303
Cdd:cd13125  232 IivrnILIRQLGWEAAGYWQAVWKISDVyLGFITTALSTYYLPRL--SAIKDNKELKREVNKQLKVILPLVAIGALLIYL 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446778895 304 ADPsFWIVTLLGEEYAPAGDALAILAFMVILQSINYPLADNLTTIGQQWKRATTMGIGLAVAIISYIVLGSQFGMMGAAI 383
Cdd:cd13125  310 LRD-LIIQILFSEEFLPARELFLWQLIGDFFKIASWLLGYILLAKGMTKLFIITEILFALLFVLLSLLFIPLFGLEGAGI 388

                        330       340
                 ....*....|....*....|.
gi 446778895 384 AAILTEITLLIGFTLFVRKGF 404
Cdd:cd13125  389 AYAINYILYLILMYFIFRKLL 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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