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Conserved domains on  [gi|446783564|ref|WP_000860820|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacillus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
7-102 8.67e-49

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 150.79  E-value: 8.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446783564   7 PVEATLEVIGGKWKVVILCHLKKDKKRTCELKQLMSGITQKMLTQQLRELEEDGVIERKVYNQVPPKVEYSLTDYGHSLD 86
Cdd:COG1733   11 PVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLL 90

                         90
                 ....*....|....*.
gi 446783564  87 SILDTLCNWGENHLEK 102
Cdd:COG1733   91 PVLDALAEWGEEHLPE 106
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
7-102 8.67e-49

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 150.79  E-value: 8.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446783564   7 PVEATLEVIGGKWKVVILCHLKKDKKRTCELKQLMSGITQKMLTQQLRELEEDGVIERKVYNQVPPKVEYSLTDYGHSLD 86
Cdd:COG1733   11 PVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLL 90

                         90
                 ....*....|....*.
gi 446783564  87 SILDTLCNWGENHLEK 102
Cdd:COG1733   91 PVLDALAEWGEEHLPE 106
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 14-101 1.03e-44

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 140.13  E-value: 1.03e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446783564   14 VIGGKWKVVILCHLKKDKKRTCELKQLMSGITQKMLTQQLRELEEDGVIERKVYNQVPPKVEYSLTDYGHSLDSILDTLC 93
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*...
gi 446783564   94 NWGENHLE 101
Cdd:pfam01638  81 DWGEEYLE 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-88 6.48e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.44  E-value: 6.48e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446783564  12 LEVIGGKWKVVILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIERKvynQVPPKVEYSLTDYGHSLDSI 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALL 73
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-80 1.18e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.19  E-value: 1.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446783564    23 ILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIERKvynQVPPKVEYSLTD 80
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESR---REGKRVYYSLTD 55
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 23-80 3.65e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.59  E-value: 3.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446783564  23 ILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIE-----RKVYnqvppkveYSLTD 80
Cdd:NF033788  16 ILELLAEGELCVCELAEAL-GLSQSAVSQHLKVLRDAGLVTsrregRWVY--------YRLAD 69
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
7-102 8.67e-49

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 150.79  E-value: 8.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446783564   7 PVEATLEVIGGKWKVVILCHLKKDKKRTCELKQLMSGITQKMLTQQLRELEEDGVIERKVYNQVPPKVEYSLTDYGHSLD 86
Cdd:COG1733   11 PVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLL 90

                         90
                 ....*....|....*.
gi 446783564  87 SILDTLCNWGENHLEK 102
Cdd:COG1733   91 PVLDALAEWGEEHLPE 106
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 14-101 1.03e-44

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 140.13  E-value: 1.03e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446783564   14 VIGGKWKVVILCHLKKDKKRTCELKQLMSGITQKMLTQQLRELEEDGVIERKVYNQVPPKVEYSLTDYGHSLDSILDTLC 93
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*...
gi 446783564   94 NWGENHLE 101
Cdd:pfam01638  81 DWGEEYLE 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-88 6.48e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.44  E-value: 6.48e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446783564  12 LEVIGGKWKVVILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIERKvynQVPPKVEYSLTDYGHSLDSI 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALL 73
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-80 1.18e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.19  E-value: 1.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446783564    23 ILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIERKvynQVPPKVEYSLTD 80
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESR---REGKRVYYSLTD 55
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
23-94 3.07e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 36.79  E-value: 3.07e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446783564  23 ILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIE-----RKVYnqvppkveYSLTDygHSLDSILDTLCN 94
Cdd:COG0640   25 ILRLLAEGELCVGELAEAL-GLSQSTVSHHLKVLREAGLVTsrregRWVY--------YRLAD--EALAELLEWLLE 90
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
23-92 2.60e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 35.64  E-value: 2.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446783564  23 ILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIERKVYnqvppkvEYSLTDYG----HSLDSILDTL 92
Cdd:COG4742   21 ILLLLAEGPKTRSELAESL-DVSRSTILRQLKELEERGLIERDDG-------EYELTTLGrlvvEEMEPLLDTL 86
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 23-80 3.65e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 33.59  E-value: 3.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446783564  23 ILCHLKKDKKRTCELKQLMsGITQKMLTQQLRELEEDGVIE-----RKVYnqvppkveYSLTD 80
Cdd:NF033788  16 ILELLAEGELCVCELAEAL-GLSQSAVSQHLKVLRDAGLVTsrregRWVY--------YRLAD 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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