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Conserved domains on  [gi|446788651|ref|WP_000865907|]
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MULTISPECIES: PTS sugar transporter subunit IIB [Bacillus]

Protein Classification

PTS sugar transporter subunit IIB( domain architecture ID 10144914)

subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS)

CATH:  3.40.50.2300
EC:  2.7.1.-
Gene Ontology:  GO:0008643|GO:0009401|GO:0008982
PubMed:  8246840|2197982|11361063

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIB_chitobiose_lichenan cd05564
PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N, ...
 2-98 1.83e-40

PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


:

Pssm-ID: 99906  Cd Length: 96  Bit Score: 128.77  E-value: 1.83e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   2 KVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVkNGWDVVMVAPQIRHRFDSVKKFAEEESIPCGIIPP 81
Cdd:cd05564    1 KILLVCSAGMSTSILVKKMKKAAEKRGIDAEIEAVPESELEEYI-DDADVVLLGPQVRYMLDEVKKKAAEYGIPVAVIDM 79

                         90
                 ....*....|....*..
gi 446788651  82 QAYTPLGGPTLLKTVNE 98
Cdd:cd05564   80 MDYGMMNGEKVLKQALK 96
 
Name Accession Description Interval E-value
PTS_IIB_chitobiose_lichenan cd05564
PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N, ...
 2-98 1.83e-40

PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99906  Cd Length: 96  Bit Score: 128.77  E-value: 1.83e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   2 KVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVkNGWDVVMVAPQIRHRFDSVKKFAEEESIPCGIIPP 81
Cdd:cd05564    1 KILLVCSAGMSTSILVKKMKKAAEKRGIDAEIEAVPESELEEYI-DDADVVLLGPQVRYMLDEVKKKAAEYGIPVAVIDM 79

                         90
                 ....*....|....*..
gi 446788651  82 QAYTPLGGPTLLKTVNE 98
Cdd:cd05564   80 MDYGMMNGEKVLKQALK 96
CelA COG1440
Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and ...
 1-101 5.78e-39

Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism];


Pssm-ID: 441049  Cd Length: 100  Bit Score: 125.25  E-value: 5.78e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   1 MKVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNgWDVVMVAPQIRHRFDSVKKFAEEESIPCGIIP 80
Cdd:COG1440    1 KKILLVCAAGMSTSLLVKKMKKAAKERGIDVEIEAVSAGELEDVIDD-YDVVLLGPQVRYMLDEIKKIADEKGIPVAVID 79

                         90       100
                 ....*....|....*....|.
gi 446788651  81 PQAYTPLGGPTLLKTVNELIS 101
Cdd:COG1440   80 MQDYGMMDGEKVLDQALELLK 100
pts-lac TIGR00853
PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and ...
 3-89 3.75e-16

PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as those in E. coli. While the Lac family usually consists of two polypeptide components IIA and IICB, the Chb permease of E. coli consists of three IIA, IIB and IIC. This family is specific for the IIB subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273300  Cd Length: 95  Bit Score: 67.42  E-value: 3.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651    3 VLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNgWDVVMVAPQIRHRFDSVKKFAEEESIPCGIIPPQ 82
Cdd:TIGR00853   6 ILLLCAAGMSTSLLVNKMNKAAEEYGVPVKIAAGSYGAAGEKLDD-ADVVLLAPQVAYMLPDLKKETDKKGIPVEVINGA 84


                  ....*..
gi 446788651   83 AYTPLGG 89
Cdd:TIGR00853  85 QYGKLTG 91
celB PRK09590
PTS cellobiose transporter subunit IIB;
2-87 1.08e-15

PTS cellobiose transporter subunit IIB;


Pssm-ID: 181974  Cd Length: 104  Bit Score: 66.35  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   2 KVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNG-WDVVMVAPQIRHRFDSVKKFAEEESIPCGIIP 80
Cdd:PRK09590   3 KALIICAAGMSSSMMAKKTTEYLKEQGKDIEVDAITATEGEKAIAAAeYDLYLVSPQTKMYFKQFEEAGAKVGKPVVQIP 82


                 ....*..
gi 446788651  81 PQAYTPL 87
Cdd:PRK09590  83 PQAYIPI 89
PTS_IIB pfam02302
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar ...
 2-94 1.12e-10

PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.


Pssm-ID: 396744  Cd Length: 92  Bit Score: 53.11  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651    2 KVLFVCSGGM-SSAIVVNALKKEAEKNGVnmeVHAIGTNEVE----EEVKNGWDVVMVAPQIrhRFDSVKKFAEeesIPC 76
Cdd:pfam02302   1 KILTACGAGMaTSLMAAEALEKAAKELGI---VEAQGAAGVNeltaEDIADDADVVILAPDV--AVEDLARFAG---KPV 72

                          90
                  ....*....|....*....
gi 446788651   77 GIIPPQ-AYTPLGGPTLLK 94
Cdd:pfam02302  73 YVIPVKdALGMKDAEEVLE 91
 
Name Accession Description Interval E-value
PTS_IIB_chitobiose_lichenan cd05564
PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N, ...
 2-98 1.83e-40

PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99906  Cd Length: 96  Bit Score: 128.77  E-value: 1.83e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   2 KVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVkNGWDVVMVAPQIRHRFDSVKKFAEEESIPCGIIPP 81
Cdd:cd05564    1 KILLVCSAGMSTSILVKKMKKAAEKRGIDAEIEAVPESELEEYI-DDADVVLLGPQVRYMLDEVKKKAAEYGIPVAVIDM 79

                         90
                 ....*....|....*..
gi 446788651  82 QAYTPLGGPTLLKTVNE 98
Cdd:cd05564   80 MDYGMMNGEKVLKQALK 96
CelA COG1440
Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and ...
 1-101 5.78e-39

Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism];


Pssm-ID: 441049  Cd Length: 100  Bit Score: 125.25  E-value: 5.78e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   1 MKVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNgWDVVMVAPQIRHRFDSVKKFAEEESIPCGIIP 80
Cdd:COG1440    1 KKILLVCAAGMSTSLLVKKMKKAAKERGIDVEIEAVSAGELEDVIDD-YDVVLLGPQVRYMLDEIKKIADEKGIPVAVID 79

                         90       100
                 ....*....|....*....|.
gi 446788651  81 PQAYTPLGGPTLLKTVNELIS 101
Cdd:COG1440   80 MQDYGMMDGEKVLDQALELLK 100
pts-lac TIGR00853
PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and ...
 3-89 3.75e-16

PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as those in E. coli. While the Lac family usually consists of two polypeptide components IIA and IICB, the Chb permease of E. coli consists of three IIA, IIB and IIC. This family is specific for the IIB subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273300  Cd Length: 95  Bit Score: 67.42  E-value: 3.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651    3 VLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNgWDVVMVAPQIRHRFDSVKKFAEEESIPCGIIPPQ 82
Cdd:TIGR00853   6 ILLLCAAGMSTSLLVNKMNKAAEEYGVPVKIAAGSYGAAGEKLDD-ADVVLLAPQVAYMLPDLKKETDKKGIPVEVINGA 84


                  ....*..
gi 446788651   83 AYTPLGG 89
Cdd:TIGR00853  85 QYGKLTG 91
celB PRK09590
PTS cellobiose transporter subunit IIB;
2-87 1.08e-15

PTS cellobiose transporter subunit IIB;


Pssm-ID: 181974  Cd Length: 104  Bit Score: 66.35  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   2 KVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNG-WDVVMVAPQIRHRFDSVKKFAEEESIPCGIIP 80
Cdd:PRK09590   3 KALIICAAGMSSSMMAKKTTEYLKEQGKDIEVDAITATEGEKAIAAAeYDLYLVSPQTKMYFKQFEEAGAKVGKPVVQIP 82


                 ....*..
gi 446788651  81 PQAYTPL 87
Cdd:PRK09590  83 PQAYIPI 89
PTS_IIB pfam02302
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar ...
 2-94 1.12e-10

PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.


Pssm-ID: 396744  Cd Length: 92  Bit Score: 53.11  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651    2 KVLFVCSGGM-SSAIVVNALKKEAEKNGVnmeVHAIGTNEVE----EEVKNGWDVVMVAPQIrhRFDSVKKFAEeesIPC 76
Cdd:pfam02302   1 KILTACGAGMaTSLMAAEALEKAAKELGI---VEAQGAAGVNeltaEDIADDADVVILAPDV--AVEDLARFAG---KPV 72

                          90
                  ....*....|....*....
gi 446788651   77 GIIPPQ-AYTPLGGPTLLK 94
Cdd:pfam02302  73 YVIPVKdALGMKDAEEVLE 91
PTS_IIB cd00133
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the ...
 2-68 3.05e-10

PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system. The PTS is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, polyols, amino sugars, and other sugar derivatives. The four proteins (domains) forming the PTS phosphorylation cascade (EI, HPr, EIIA, and EIIB), can phosphorylate or interact with numerous non-PTS proteins thereby regulating their activity.


Pssm-ID: 99904  Cd Length: 84  Bit Score: 51.87  E-value: 3.05e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446788651   2 KVLFVCSGG-MSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEvkNGWDVVMVAPQIRHRFDSVKKF 68
Cdd:cd00133    1 KILVVCGSGiGSSSMLAEKLEKAAKELGIEVKVEAQGLSEVIDL--ADADLIISTVPLAARFLGKPVI 66
PTS_IIB_lactose cd05565
PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate: ...
 2-76 8.41e-10

PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIC and IIB domains are expressed as a single protein from the lac operon. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include lactose, chitobiose/lichenan, ascorbate, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99907  Cd Length: 99  Bit Score: 51.25  E-value: 8.41e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446788651   2 KVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAiGTNEVEEEVKNGWDVVMVAPQIRHRFDSVKKFAEEESIPC 76
Cdd:cd05565    2 NVLVLCAGGGTSGLLANALNKGAKERGVPLEAAA-GAYGSHYDMIPDYDLVILAPQMASYYDELKKDTDRLGIKL 75
SgaB COG3414
Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and ...
 1-58 3.05e-06

Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism];


Pssm-ID: 442640  Cd Length: 94  Bit Score: 41.70  E-value: 3.05e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446788651   1 MKVLFVCSGGM-SSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNgWDVVMVAPQI 58
Cdd:COG3414    2 KKILVVCGSGLgTSTMLKMKIEKVLKELGIDAEVEHCDVSSAKSKADD-ADLIVTTTDL 59
PRK10499 PRK10499
PTS sugar transporter subunit IIB;
2-94 1.68e-04

PTS sugar transporter subunit IIB;


Pssm-ID: 182499  Cd Length: 106  Bit Score: 37.59  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446788651   2 KVLFVCSGGMSSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKNGwDVVMVAPQIRHRFDSVKKFAEEEsiPCGIIPP 81
Cdd:PRK10499   5 HIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQNA-DVVLLGPQIAYMLPEIQRLLPNK--PVEVIDS 81

                         90
                 ....*....|...
gi 446788651  82 QAYTPLGGPTLLK 94
Cdd:PRK10499  82 LLYGKVDGLGVLK 94
PTS_IIB_mannitol cd05567
PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate: ...
 1-52 5.59e-03

PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIA, IIB, and IIC domains are expressed from the mtlA gene as a single protein, also known as the mannitol PTS permease, the mtl transporter, or MtlA. MtlA is only functional as a dimer with the dimer contacts occuring between the IIC domains. MtlA takes up exogenous mannitol releasing the phosphate ester into the cytoplasm in preparation for oxidation to fructose-6-phosphate by the NAD-dependent mannitol-P dehydrogenase (MtlD). The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include mannitol, chitobiose/lichenan, ascorbate, lactose, galactitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99909 [Multi-domain]  Cd Length: 87  Bit Score: 32.93  E-value: 5.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446788651   1 MKVLFVCSGGM-SSAIVVNALKKEAEKNGVNMEVhaigTNEVEEEVKNGWDVV 52
Cdd:cd05567    1 KKIVFACDAGMgSSAMGASVLRKKLKKAGLEIPV----TNSAIDELPSDADLV 49
PTS_IIB_galactitol cd05566
PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific ...
 2-53 8.45e-03

PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99908  Cd Length: 89  Bit Score: 32.51  E-value: 8.45e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446788651   2 KVLFVCSGGM-SSAIVVNALKKEAEKNGVNMEVHAIGTNEVEEEVKnGWDVVM 53
Cdd:cd05566    2 KILVACGTGVaTSTVVASKVKELLKENGIDVKVEQCKIAEVPSLLD-DADLIV 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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