|
Name |
Accession |
Description |
Interval |
E-value |
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
2-460 |
0e+00 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 800.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 2 LAFLNQVRKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVG 81
Cdd:PRK09556 1 LAFLNQVRKPTLDLPLEVQRKMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 82 KTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFL 161
Cdd:PRK09556 81 KTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 162 GFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGEEISEEDKETE 241
Cdd:PRK09556 161 GFWNISHNLGGAGAGGVALWGANYFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 242 STDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDL 321
Cdd:PRK09556 241 STDMTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 322 ANGRRGLVACIALALIIATLGVYQHASNQYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDS 401
Cdd:PRK09556 321 ANGRRALVACIALALIIFTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDS 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446801934 402 FAKLGLGMIAD----GTPVFG--LTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQL 460
Cdd:PRK09556 401 FAKVGLGMIADptknGTPIFGytLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQL 465
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
28-444 |
3.00e-170 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 484.44 E-value: 3.00e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 28 FMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAI 107
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 108 CMLGFSASMGSGSvSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLF 187
Cdd:cd17345 81 INILIGFVPSATS-SVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 188 DGHVIGMFIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFA 267
Cdd:cd17345 160 DGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 268 NIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSD-LANGRRGLVACIALALIIATLGVYQH 346
Cdd:cd17345 240 NVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDkLFKGRRAPTGIIFMILVIVALIVYWL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 347 ASNQYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADgtpvfgLTGWAGTF 426
Cdd:cd17345 320 APNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVD------HFGWNGGF 393
|
410
....*....|....*...
gi 446801934 427 AALDIAAIGCICLMAIVA 444
Cdd:cd17345 394 IVLLASCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-426 |
1.83e-140 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 407.53 E-value: 1.83e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 36 FIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSAS 115
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 116 MgsgsvSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIgmF 195
Cdd:TIGR00881 81 T-----SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV--F 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 196 IFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGEEiSEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFLYVVR 275
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE-PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 276 IGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSD-LANGRRGLVACIALALIIATLGVYQH--ASNQYI 352
Cdd:TIGR00881 233 TGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLM 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446801934 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGtpvfglTGWAGTF 426
Cdd:TIGR00881 313 DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADG------FGWAGAF 379
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
7-459 |
4.35e-60 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 203.02 E-value: 4.35e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 7 QVRKPTLDLPLEVRRKMWfkpfmQSYLVVFIGYLTMYLIRKNFNIAQNDMISTyGLSMTQLGMIGLGFSITYGVGKTLVS 86
Cdd:PRK11273 11 KARLPAAEIDPTYRRLRW-----QIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 87 YYADGKNTKQFLPFMLILSAICMLGFS-ASMGSGSVSLFLMIAFyaLSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWN 165
Cdd:PRK11273 85 SVSDRSNPRVFLPAGLILAAAVMLFMGfVPWATSSIAVMFVLLF--LCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 166 ISHNLGGAGAAGVALFGANYLFDGHviGMFIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEElFGEEISEEDKETESTDM 245
Cdd:PRK11273 163 CAHNVGGGLPPLLFLLGMAWFNDWH--AALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEE-YKNDYPDDYNEKHEQEL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 246 TKWQIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYafqeLKLSKAVAIQ----GFTLFEAGALVGTLLWGWLSD- 320
Cdd:PRK11273 240 TAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTY----LKEVKHFALDksswAYFLYEYAGIPGTLLCGWMSDk 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 321 LANGRRGLVACIALALI-IATLgVY--QHASNQYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYL 397
Cdd:PRK11273 316 VFRGNRGATGVFFMTLVtIATI-VYwlNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYL 394
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446801934 398 IGDSFAKLGLGMIADgtpvfgLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQ 459
Cdd:PRK11273 395 GGSVAASAIVGYTVD------FFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKRN 450
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
33-433 |
3.92e-58 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 197.63 E-value: 3.92e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAIC--ML 110
Cdd:PRK11663 26 ITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIIniLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 111 GFSASmgsgsvsLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGAnyLFDGH 190
Cdd:PRK11663 106 GFSSS-------LWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIA--LHYGW 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 191 VIGMfIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGEEIsEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIF 270
Cdd:PRK11663 177 RYGM-MIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDAL-ELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 271 LYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSD-LANGRRGLVACI-ALALIIATLGVYQHAS 348
Cdd:PRK11663 255 VYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDkLFNGNRGPMNLIfAAGILLSVGSLWLMPF 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 349 NQYIYLAS-LFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADgtpvfgLTGWAGTFA 427
Cdd:PRK11663 335 ASYVMQAAcFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLE------IWHWTGFFV 407
|
....*.
gi 446801934 428 ALDIAA 433
Cdd:PRK11663 408 VISIAA 413
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-440 |
1.10e-50 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 175.93 E-value: 1.10e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 30 QSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICM 109
Cdd:cd17312 3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 110 LGFSAsmgsgSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYlFDG 189
Cdd:cd17312 83 IFMGF-----STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASY-YGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 190 HVIgmFIFPSIIALIVGFIGLRYGSDSPeayglgkaeelfgeeiseedketestdmtkwqifveyvlknKVIWLLCFANI 269
Cdd:cd17312 157 RAA--FLVPGIVGLVVAIILFFFLRDSP-----------------------------------------PYVWVLSLAYA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 270 FLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLA-NGRRGLVACIALALIIATLGVYQHAS 348
Cdd:cd17312 194 FVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWFFP 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 349 NQYIYLASLFAL-GFLVFGPQLLIG-VAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADGtpvfglTGWAGTF 426
Cdd:cd17312 274 HNKLLSIVLLFLiGFFVGGPINLIGgAAAQDIGRKEAAGTATGFVGLFGY-LGASLAGLPLGYIIDH------YGWSTVF 346
|
410
....*....|....
gi 446801934 427 AALDIAAIGCICLM 440
Cdd:cd17312 347 YFLISAALLSVLLL 360
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
35-441 |
2.19e-48 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 169.89 E-value: 2.19e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 35 VFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSA 114
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 115 SMgsgsvSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNlggagaagvalfganylfdghvIGM 194
Cdd:cd17488 88 SS-----SLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHN----------------------IGG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 195 FIFPSIIALIVGFIGLRYGSDSPEAYGLGKAeelfgeeiseedketestdmtkwqIFVEYVLKNK--VIWLLCFANIFLY 272
Cdd:cd17488 141 ALIPILTGFAALTYGWRAGMYVPGIIAILMG------------------------IVLCWRLRDRppYIWLLAFCYVLVY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 273 VVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSD-LANGRRGLVACI-ALALIIATLGVYQHASNQ 350
Cdd:cd17488 197 VVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDkLFKGNRGPMNLIfALGLLVSVGALWLVPVHS 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 351 YIYLASLF-ALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADgtpvfgLTGWAGTFAAL 429
Cdd:cd17488 277 YWLLATCFfTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYL-GAALAGYPLAKVIE------SWGWSGFFIVI 349
|
410
....*....|..
gi 446801934 430 DIAAIGCICLMA 441
Cdd:cd17488 350 SIAAAISGLLLL 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-444 |
3.24e-39 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 145.01 E-value: 3.24e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 113 SAsmgsgSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2271 93 GF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 193 GMFIFPSIIALIVGFIGlrygsdspeayglgkaeelfgeeiseedketestdmtkwqifveyvlknkvIWLLCFANIFLY 272
Cdd:COG2271 165 AAFLILGLPGLLLALLR---------------------------------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 273 VVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNQYI 352
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvfgLTGWAGTFAALDIA 432
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLD------ATGYQAAFLLLAAL 346
|
410
....*....|..
gi 446801934 433 AIGCICLMAIVA 444
Cdd:COG2271 347 ALLAALLALLLL 358
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
31-435 |
3.50e-23 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 101.26 E-value: 3.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 31 SYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICML 110
Cdd:cd17343 4 IFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 111 GFSasmgsGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdGH 190
Cdd:cd17343 84 AFS-----GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY--GW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 191 VIGMFIfPSIIALIVGFIGLRYGSDSPEAYGLGKAEElfgeEISEEDKETESTDMTKWQifveYVLKNKVIWLLCFANIF 270
Cdd:cd17343 157 RSTLSI-SGTVAVVMSVVCLLFIKNEPSDVGLNNIEE----EESKGKKKKSPRGESTLK----ELLLSPFLWLLSLGYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 271 LYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGL--------------VACIALAL 336
Cdd:cd17343 228 VFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSssrgnprmplalvfMAGLTVSL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 337 IIATLGVYQHASNQYIYLASlFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpv 416
Cdd:cd17343 308 HLFRVHITSDSSELFILLLG-FLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAK---- 381
|
410
....*....|....*....
gi 446801934 417 fgLTGWAGTFAALDIAAIG 435
Cdd:cd17343 382 --HYDWRTAFLLLEILCAI 398
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
35-429 |
6.81e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.95 E-value: 6.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 35 VFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSa 114
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 115 smgsGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGAnYLFDGHVIGM 194
Cdd:cd06174 80 ----FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 195 FIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGEeiseedketestdmtkWQIFVEYVLKNKVIWLLCFANIFLYVV 274
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESARAKNEEASSKS----------------VLKLLKRVLKNPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 275 RIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVAcIALALIIATLGVYQHASNQYIYL 354
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL-IGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446801934 355 ASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADGTPVFGLTGWAGTFAAL 429
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL-GGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
33-455 |
1.77e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.78 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 113 SASmgsgsVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2223 88 ALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 193 GMFIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGeeiseedketestdmtkwqifVEYVLKNKVIWLLCFANIFLY 272
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD---------------------QLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 273 VVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALaLIIATLGVYQHASNQYI 352
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL-MALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 353 YLASLFALGFLvFGPQLLIGVAAVG-FVPKKAIGAADGIKGTfAYLIGDSFAKLGLGMIADgtpvfgltgWAGTFAALDI 431
Cdd:COG2223 298 FLVLFLLLGLA-LGGGNGAVFALVPdIFPTKNAGAVYGLVGA-AGGLGGFLGPLLFGALLD---------ATGSYTAAFL 366
|
410 420
....*....|....*....|....
gi 446801934 432 AAIGCICLMAIVAVMEERKIRREK 455
Cdd:COG2223 367 VFAVLALVALVLTLLLYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-400 |
1.21e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.79 E-value: 1.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 33 LVVFIGYLTMYLIrknfNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2814 17 LGAFLSGLGIGIV----LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 113 SASMgsgsvSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2814 93 ALAP-----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 193 GMFIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGeeiseedketestdmtkwqifveyVLKNKVIWLLCFANIFLY 272
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------------------------LLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 273 VVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVacIALALIIATLGVYQHASNQYI 352
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446801934 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGD 400
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
35-399 |
3.84e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.38 E-value: 3.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 35 VFIGYLTMYLIRKNFNIA-QNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFS 113
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 114 ASmgsgsVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVIG 193
Cdd:pfam07690 81 FA-----SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---GWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 194 MFIFPSIIALIVGFIGLRYGSDSPEAYGLGKAEELFGEEISeedketestdmtkwqifVEYVLKNKVIWLLcFANIFLYV 273
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-----------------WKALLRDPVLWLL-LALLLFGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 274 VRIGIDQWSTVYAfQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSD-LANGRRGLVACIALALIIATLGVYQHASNQYI 352
Cdd:pfam07690 215 AFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLW 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446801934 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIG 399
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-440 |
4.21e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.20 E-value: 4.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 56 MISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICM--LGFSAsmgsgsvSLFLMIAFYALS 133
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLslLGFAP-------NYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 134 GFfqstgGSCSY----STITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDghvIGMFIFPSIIALIVGFIG 209
Cdd:cd17478 95 GI-----GSAAFhpegARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG---LGLLILLIIPGLAVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 210 LRYGSDSPEAYGLGKAEELFGEeiseedketestdmtkwqifvEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYaFQE 289
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSARS---------------------TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFY-LVQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 290 LKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIiaTLGVYQHASNQYIYLaSLFALGFLVFGPQL 369
Cdd:cd17478 225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAP--FLLLFLLTPGIWSYI-LLVLAGFLLFASFP 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446801934 370 LIGVAAVGFVPKKaIGAADGIKGTFAYLIGdSFAKLGLGMIADgtpVFGLTgWAGTFAALdIAAIGCICLM 440
Cdd:cd17478 302 VTVVLAQELLPGN-VGLASGLMMGLSFGLG-GIGAPVLGALAD---AFGLE-SVLLILAL-LPLLGALLAF 365
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-442 |
4.66e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 67.21 E-value: 4.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAIcmlgF 112
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL----F 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 113 SASMGsGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANyLFDGHvi 192
Cdd:cd17319 82 TALTG-FATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-LFGWR-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 193 GMFIFPSIIALIVGFIGLRYGsdspeayglgkaeelfgeeiseedketestdmtkwqifveyvlknKVIWLLCFANIFLY 272
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFYL---------------------------------------------RQVWGLALGYFGIN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 273 VVRIGIDQWSTVYAFQELklskavaiqGFTLFEAG---------ALVGTLLWGWLSD-LANGRRGLVACIALALIIATLG 342
Cdd:cd17319 193 YALYGLLTWLPTYLKQAR---------GFSLKQVGllaaipflaGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 343 VYQHASNQYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGTpvfGLTGW 422
Cdd:cd17319 264 LAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLLIGYLVDAT---GSYTA 339
|
410 420
....*....|....*....|
gi 446801934 423 AGTFAALdIAAIGCICLMAI 442
Cdd:cd17319 340 AFLFLAA-VALLAALLVLLL 358
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
67-448 |
6.28e-12 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 66.96 E-value: 6.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 67 LGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGSGSVSLFLMIAFYALSGFFQSTGGSCSYS 146
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 147 TITKWTPRRKRGTFLGFWNiSHNlggagaagVALFGANYLFDGHVI----GM-FIFPSIIALIVGFIGLRYGSDSPEAyg 221
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWN-SHT--------SVGNILGSLIAGIFVssawGLsFIVPGIIIAAMGVLVFLFLVEHPPG-- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 222 lgkaeelfgeeiseedketestdmtkwqiFVEYVLknkviwLLCFANI----FLYvvrigidqWSTVYAFQELKLSKAVA 297
Cdd:cd17344 213 -----------------------------VIEFSL------CLFFAKLvsytFLY--------WLPLYISNTAILSAKKA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 298 IQGFTLFEAGALVGTLLWGWLSDLANGrRGLVACIALALIIATLGVYQH--ASNQYIYLASLFALGFLVFGPQLLIGVAA 375
Cdd:cd17344 250 GDLSTLFDVGGIVGGILAGYISDYTGG-RATTCAAMLILAAPMLFIYNYfgQVSMTTNIVLLIVCGLLVNGPYALITTAV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 376 vgfvpkkaigAADgiKGTFAYLIGDSFAKLGLGMIADGTPVFGL------------TGWAGTFAALdIAAIGCICLMAIV 443
Cdd:cd17344 329 ----------SAD--LGTHKSLKGNARALATVTAIIDGTGSIGAalgpllaglissRGWNNVFYML-IAADVCAGLLLTR 395
|
....*
gi 446801934 444 AVMEE 448
Cdd:cd17344 396 LVYKE 400
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-454 |
2.45e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.18 E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 23 MWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFML 102
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 103 ILSAICMLGFSASMgsgsvSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKR---GTFLGFWNISHNLGGAGAAGVA 179
Cdd:COG0738 81 LLMALGLLLFALAP-----SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 180 LFGANYLFDGHVIGMFIFPSIIALIVGFIGLRygsdspeayglgkaeelfgeEISEEDKETESTDMTKWQIFveyvlKNK 259
Cdd:COG0738 156 LLGLSLSWHLPYLILAVLLLLLALLFLRSKLP--------------------EIEEEEEEAAGSAASLKSLL-----KNP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 260 VIWLLCFAnIFLYV-VRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALII 338
Cdd:COG0738 211 RLLLGGLA-IFLYVgAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 339 ATLGVYqhASNQYIYLASLFALGFLVfGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvfg 418
Cdd:COG0738 290 LLLALL--APGPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLAD------ 359
|
410 420 430
....*....|....*....|....*....|....*.
gi 446801934 419 LTGWAGTFaaldIAAIGCICLMAIVAVMEERKIRRE 454
Cdd:COG0738 360 AFGLRAAF----LVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-442 |
8.28e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 8.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 32 YLVVFIGYLTMYLIRKNFNIaqndMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLG 111
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPL----YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 112 FSASMgsgsvSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLggagaagvalfganylfdGHV 191
Cdd:cd17325 78 FAFAT-----SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGL------------------GFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 192 IG---------------MFIFPSIIALIVGFIGLRYGSDSPEAyglgkaeelfgeeiseedKETESTDMTKWQIFVEYVL 256
Cdd:cd17325 135 IGpllgglladalgyraPFLVCAALALLALVLALLLLPEPRPP------------------PNKRAVSAARLRSGLRLLL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 257 KNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRglVACIALAL 336
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP--LILIGLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 337 IIATLGVYQHASNQYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFaYLIGDSFAKLGLGMIADgtpv 416
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYD---- 349
|
410 420
....*....|....*....|....*.
gi 446801934 417 fgLTGWAGTFAALDIAAIGCICLMAI 442
Cdd:cd17325 350 --AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-439 |
2.94e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 55.70 E-value: 2.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 34 VVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKqflpfmlILSAICMLGFS 113
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRK-------WILAVGILIWS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 114 ASMGSGSVS--LFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHV 191
Cdd:cd17328 76 AATLLSSFApnFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 192 IgmFIFPSIIALIVGFIGLRYGSDSPEAyglgkaeelfgeeiSEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFANIFL 271
Cdd:cd17328 156 A--FRVTGVLGVLLAILLLLFVREPPRG--------------AAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 272 YVVRIGIDQWSTVY---AFQELKLSKAVAIQGFTLFEA-GALVGTLLWGWLSDLANGR--RGLVACIALALIIAT----L 341
Cdd:cd17328 220 SFVTGALAFWAPTFflrAFGVGDLSSADVGLIFGAITCiAGVLGVLLGGILADRLRRKtpRADPLVCAVGLLAAApflfL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 342 GVYQHASNQYIYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIAD------GTP 415
Cdd:cd17328 300 ALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDllrqnkDSP 379
|
410 420
....*....|....*....|....*
gi 446801934 416 VFGLTGWA-GTFAALDIAAIGCICL 439
Cdd:cd17328 380 LAEAASLQyALLLCSFVLVLGGFFF 404
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
60-435 |
3.98e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 3.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 60 YGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKqflpFMLILSAICMLGFSASMGSgSVSLFLMIAFYALSGFFQST 139
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRK----KALILTLLLFGLATLLIGL-LPTPILLLVLRFLQGIGIGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 140 GGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVI-GMFIFPSIIALIVGFIGLRygsdspe 218
Cdd:cd17316 106 EYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWrILFLIGALPALLALLLRRR------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 219 ayglgkaeelfgeeiseedketestdmtkwqifveyvlknkvIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAI 298
Cdd:cd17316 179 ------------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 299 QGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNQYIYLASLFALGFLVFGPQLLIGVAAVGF 378
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446801934 379 VPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGTPVFGLTGWAGTFAALDIAAIG 435
Cdd:cd17316 297 FPTEVRATGVGLSYNLGRLGG-GGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
255-446 |
5.24e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.47 E-value: 5.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 255 VLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSD-LANGRRGLVACIA 333
Cdd:cd17475 194 VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDrVFGGRRRPVLVIT 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 334 LALIIATLGVYQ--HASNQYIYLASLFAL-GFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLigdsfaklglgMI 410
Cdd:cd17475 274 AAIAAAALLVLSllSPGTPLWLLVLLLILlGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFI-----------GI 342
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 446801934 411 ADGTPVFGL-----TGWAGTFAALdiaaigCICLMAIVAVM 446
Cdd:cd17475 343 AIGPPLFGLlvdatHSYAPAWLAL------ALLLVLAALLL 377
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
33-372 |
7.25e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 51.10 E-value: 7.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 33 LVVFIGYLTMYLIRKNFNIAQ-NDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLg 111
Cdd:cd17327 8 PLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTL- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 112 FSASMGSGSVslflMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHV 191
Cdd:cd17327 87 LTAAVKNFGG----LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 192 IG---MFIFPSIIALIVGFIGLRYGSDSPE-AYGLGKAEELFGEEISEEDKETESTDMTKWQIFVEyVLKNKVIWLLCFA 267
Cdd:cd17327 163 AGwrwLFIIEGLITIIIGLVIFFWLPDNPSkAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKE-AFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 268 NIFLYVVRIGIDQWSTV-------YAFQELKLSKAVAIQGFtlfeagalVGTLLWGWLSDLANGrRGLVACIALALIIAT 340
Cdd:cd17327 242 FFCSQITNNGISNFLPLilkslgfYSLQTNLLSVPIGALGA--------VSLLIAALLSDRFKK-RGLFAIFACVLALVG 312
|
330 340 350
....*....|....*....|....*....|...
gi 446801934 341 LGVYQHASNQ-YIYLASLFALGFLVFGPQLLIG 372
Cdd:cd17327 313 SIILLAAPNPpGAYFAAYILGGGSYAGFPILLS 345
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
58-362 |
2.54e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 58 STYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTK--QFLPFMLILSAICMLG----FSASMGSGSVSLFLMIAFYA 131
Cdd:COG2211 39 DVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPLALSfvllFTAPDLSPTGKLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 132 LSGFFQSTGGSCSYSTITKWTP-RRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIG---MFIFPSIIALIVGF 207
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGyrlTALIFAVLGLLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 208 IGLRYgsdspeayglgkaeelfgeeiSEEDKETESTDMTKWQIFVEyVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAF 287
Cdd:COG2211 199 LTFFG---------------------TKERPVPEEEKVSLKESLKA-LLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446801934 288 QELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRRGLVACIALALIIATLGVYQHASNQYIYLASLFALGF 362
Cdd:COG2211 257 YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
193-449 |
3.07e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 46.14 E-value: 3.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 193 GMFIFPSIIALIVGFIGlRYGSDSPEAyglgkaeelfgeEISEEDKETESTDMTKWQIFVEYVLKNKVIWLLCFanIFLY 272
Cdd:cd17371 158 VLFLLGALPALLVLFIR-RFVKEPPQW------------QAARAARRHFADRPSLRELFSPPLLRTTLLASLLA--TGAL 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 273 VVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLAnGRRGLVACIALALIIATLGVYQHASNQYI 352
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI-GRRNNFALFALGSAISILLYFFLPLSPTL 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGikgtFAYLIGDSFAKLG---LGMIADGtpvfglTGWAGTFAAL 429
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQG----FCYNVGRIIGALFpflVGFLATS------GSLGTAIAVF 371
|
250 260
....*....|....*....|
gi 446801934 430 diAAIGCICLMAIVAVMEER 449
Cdd:cd17371 372 --AAVYYIAGLVLALLLPET 389
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
67-374 |
4.11e-05 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 45.77 E-value: 4.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 67 LGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSA-SMGSGSVSLFLMIAFYALSGFFQSTGGSCSY 145
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVlTEWLHFYNKYLYCILWVLNGLLQSTGWPCVV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 146 STITKWTPRRKRGTFLGFWNISHNLggagaagvalfganylfdGHVIGmfifpSIIALIVGFIGLRYGSdspeaygLGKA 225
Cdd:cd17342 145 AIMGNWFGKSSRGFVLGLWSACASV------------------GNIIG-----ALLASSVLDYGYEYAF-------LVTS 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 226 EELFGEEISeedketestdmtkwqIFVEYVLKNKVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFE 305
Cdd:cd17342 195 SLLFAGAIV---------------VFFGLLSSPPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYD 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 306 AGALVGTLLWGWLSDLAnGRRGLVACIALALIIATLGVYQHASNQYIYLASLFAL-GFLVFGPQLLIGVA 374
Cdd:cd17342 260 VGGIIGGIVAGYISDRM-GSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTItGFFIGGPANLISSA 328
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-170 |
1.13e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 18 EVRRKMWFKPFMQSYLVVFIGYLTMYLIrknFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQF 97
Cdd:COG2814 199 SLRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446801934 98 LPFMLILSAICMLGFSASmgsgsVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNL 170
Cdd:COG2814 276 LLIGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
259-368 |
8.03e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 8.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 259 KVIWLLCFANIFLYVVRIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLAnGRRGLVACIALALII 338
Cdd:cd17369 228 RALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRV-GRRPVYLAGALLAAL 306
|
90 100 110
....*....|....*....|....*....|....*.
gi 446801934 339 ATLGVY---QHASNQYIYLASLFALGFL---VFGPQ 368
Cdd:cd17369 307 FAFPFFwllDTGSTWLIVLAAVVVLGVLhgmMYGPQ 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-170 |
2.13e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.25 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 26 KPFMQSYLVVFIGYLTMYLIRKNFNIaqnDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILS 105
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPL---YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446801934 106 AICMLGFSASmgsgsVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNL 170
Cdd:cd17325 276 AVALLLLPLA-----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
195-441 |
2.58e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.93 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 195 FIFPSIIALIVGFIGLRYGSDSPEAyglgkaeelfgeeiseedKETESTDMTKWqifvEYVLKNKVIWLLCFANIFLYVV 274
Cdd:cd17341 163 FFVPGILLAIAAVLVLLFGDDLPTG------------------KASALEFLKVQ----LAVLKNYRTWILSLLYGVTFGS 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 275 RIGIDQWSTVYAFQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLANGRR---GLVACIALALIIATLGVYQHASNQY 351
Cdd:cd17341 221 FVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRrlwWLFIVMTIGAALLSLSLPTSGTNLV 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 352 IYLASLFALGFLV-FGPQLLIGVAAvgFVPKKAIGAADGIKGTFAYLIGDSFAKL-GLGMIADGTPVFGLTGWAgtfaal 429
Cdd:cd17341 301 LFLALFVALGLGAgAGNGSVFRMVP--FIFRRELGAVTGLVGAIGGLGGFFLPLLfGSSALMTGSGVGAFSLFG------ 372
|
250
....*....|..
gi 446801934 430 dIAAIGCICLMA 441
Cdd:cd17341 373 -VLAVACTLLVW 383
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
283-443 |
5.96e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 5.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 283 TVYAfQELKLSKAVAIQGFTLFEAGALVGTLLWGWLSDLAnGRRGLVACIALALIIATLGVYQHASNQYIYLASLFALGF 362
Cdd:cd17477 212 PLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRF-DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 363 LVFGPQLLIGVAAVGFVPKKAIGAADGIkGTFAYligdsfaklGLGMIADGTPVFGLTGWAGTFAALDIAAIGCICLMAI 442
Cdd:cd17477 290 AAGPLYTLALALAGDRLPGDELVAANAA-LLLLY---------GLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
.
gi 446801934 443 V 443
Cdd:cd17477 360 L 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-170 |
7.07e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 9 RKPTLDLPLEVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYY 88
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446801934 89 ADGKNTKQFLPFMLILSAICMLGFSasMGSGSVSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISH 168
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLL--LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
|
..
gi 446801934 169 NL 170
Cdd:pfam07690 337 SL 338
|
|
| |
