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penicillin-binding protein 2 [Bacillus wiedmannii]
Protein Classification
peptidoglycan D,D-transpeptidase FtsI family protein ( domain architecture ID 11433609 )
peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
30-570
1.45e-117
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 359.91
E-value: 1.45e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 30 S I TIATSS A E RG K I S D Q NG VI LATN KK V K SLY ctsndek VSNQDTSNTLAFFNQFSNEF qh DISA E DIKSQ L qqsc KK QT 109
Cdd:COG0768 51 R I RTVPIP A P RG L I Y D R NG NV LATN VP V Y SLY ------- ADPEEVKDPEETAEKLAKLL -- GLDP E ELRKK L ---- KK KS 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 110 MNDIP L YSDINES E LTF I NKK K PNN V IIKD E WI RYYP KH E VGSQLI GYV en DLNSKYGSV GKSG I E LQ YE ND L K G K PGK T 189
Cdd:COG0768 118 RFPVY L KRNLSPE E AAR I RAL K LPG V YVEA E YK RYYP YG E LAAHVL GYV -- GEINGGDGI GKSG L E KA YE DL L R G T PGK R 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 190 LIFKMNNKKFLWNIQKV --- QK GKD IR L AL DS K LQ QKT EEAL RSQIKK i TDVNA G Y VVV T D V KTG A IL T MA NSAV FDPN T 266
Cdd:COG0768 196 RVEVDARGRVIRDLGEE kpp VP GKD LV L TI DS D LQ KIA EEAL KKAVEE - YKAKS G A VVV M D P KTG E IL A MA SYPS FDPN L 274
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 267 LY eqvssk KENIKS L s Q N K A I Q klkyg ES Y V n MA ST I KP L T ILIG L N E KLFQ P ED T YLDK G TFQYDNQN n I TNAPGTPT G 346
Cdd:COG0768 275 FV ------ GGPDEP L - R N R A V Q ----- GT Y E - PG ST F KP F T AAAA L E E GVIT P DT T FDCP G YYRVGGRT - I RDWDRGGH G 340
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 347 EI T PRQ A IIN SSN TFM t A K V AL P L fnqnng N I E K vahi WTE YLK Q FGL RS KTG V DLP F E ED G Q ye FHPTNKF en GISALL 426
Cdd:COG0768 341 TL T LTE A LAK SSN VGF - Y K L AL R L ------ G I D K ---- LYD YLK K FGL GQ KTG I DLP G E AS G L -- LPSPKRW -- YPGETA 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 427 NA S W G - G NE V h TPLQLAQ YA A TL A SK G DKY KP QILSA I I D QN G KET K KFKPI L ES -- S NRY pvkf WSV V QG GM SQNIE E - 502
Cdd:COG0768 406 TM S I G q G LS V - TPLQLAQ AY A AI A NG G VLV KP HLVKE I V D PD G EVV K EEPEV L RR vi S PET ---- AET V RE GM EGVVN E p 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 503 ------ IKNLPFH VAGKTG ---- ITGAPNEQERMINHSL F IAY AP TED P QI AV S VV IPGSNSEKN --- I AA L V TS EI L E Y 569
Cdd:COG0768 481 ggtarr AAIPGYR VAGKTG taqv VDIGNGGYYKGRHIAS F VGF AP ADN P RY AV A VV VENPGGGAY ggt V AA P V FR EI M E A 560
.
gi 446825128 570 W 570
Cdd:COG0768 561 Y 561
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
30-570
1.45e-117
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 359.91
E-value: 1.45e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 30 S I TIATSS A E RG K I S D Q NG VI LATN KK V K SLY ctsndek VSNQDTSNTLAFFNQFSNEF qh DISA E DIKSQ L qqsc KK QT 109
Cdd:COG0768 51 R I RTVPIP A P RG L I Y D R NG NV LATN VP V Y SLY ------- ADPEEVKDPEETAEKLAKLL -- GLDP E ELRKK L ---- KK KS 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 110 MNDIP L YSDINES E LTF I NKK K PNN V IIKD E WI RYYP KH E VGSQLI GYV en DLNSKYGSV GKSG I E LQ YE ND L K G K PGK T 189
Cdd:COG0768 118 RFPVY L KRNLSPE E AAR I RAL K LPG V YVEA E YK RYYP YG E LAAHVL GYV -- GEINGGDGI GKSG L E KA YE DL L R G T PGK R 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 190 LIFKMNNKKFLWNIQKV --- QK GKD IR L AL DS K LQ QKT EEAL RSQIKK i TDVNA G Y VVV T D V KTG A IL T MA NSAV FDPN T 266
Cdd:COG0768 196 RVEVDARGRVIRDLGEE kpp VP GKD LV L TI DS D LQ KIA EEAL KKAVEE - YKAKS G A VVV M D P KTG E IL A MA SYPS FDPN L 274
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 267 LY eqvssk KENIKS L s Q N K A I Q klkyg ES Y V n MA ST I KP L T ILIG L N E KLFQ P ED T YLDK G TFQYDNQN n I TNAPGTPT G 346
Cdd:COG0768 275 FV ------ GGPDEP L - R N R A V Q ----- GT Y E - PG ST F KP F T AAAA L E E GVIT P DT T FDCP G YYRVGGRT - I RDWDRGGH G 340
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 347 EI T PRQ A IIN SSN TFM t A K V AL P L fnqnng N I E K vahi WTE YLK Q FGL RS KTG V DLP F E ED G Q ye FHPTNKF en GISALL 426
Cdd:COG0768 341 TL T LTE A LAK SSN VGF - Y K L AL R L ------ G I D K ---- LYD YLK K FGL GQ KTG I DLP G E AS G L -- LPSPKRW -- YPGETA 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 427 NA S W G - G NE V h TPLQLAQ YA A TL A SK G DKY KP QILSA I I D QN G KET K KFKPI L ES -- S NRY pvkf WSV V QG GM SQNIE E - 502
Cdd:COG0768 406 TM S I G q G LS V - TPLQLAQ AY A AI A NG G VLV KP HLVKE I V D PD G EVV K EEPEV L RR vi S PET ---- AET V RE GM EGVVN E p 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 503 ------ IKNLPFH VAGKTG ---- ITGAPNEQERMINHSL F IAY AP TED P QI AV S VV IPGSNSEKN --- I AA L V TS EI L E Y 569
Cdd:COG0768 481 ggtarr AAIPGYR VAGKTG taqv VDIGNGGYYKGRHIAS F VGF AP ADN P RY AV A VV VENPGGGAY ggt V AA P V FR EI M E A 560
.
gi 446825128 570 W 570
Cdd:COG0768 561 Y 561
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
38-570
8.01e-86
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 277.87
E-value: 8.01e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 38 AE RG K I S D Q NGV I LA T N KKVK SL YCTS nd EKV SNQ D tsntl A FFNQFSNEF qh D ISA EDI KSQ L QQSCKKQTMND IPL Y S 117
Cdd:TIGR03423 48 PP RG L I L D R NGV L LA D N RPSF SL EIVP -- EKV DDL D ----- A TLDRLAKLL -- D LDP EDI ARF L KELKRSRRFEP IPL K S 118
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 118 D IN E S E LTFINKKKPN -- N V I I KDEWI RYYP KH E VGSQLI GYV ---- E N DL NSKYGS ------- V GKSGIE LQ YE ND L K G 184
Cdd:TIGR03423 119 D LT E E E VARFAVNQYR lp G V E I EARLK RYYP YG E LAAHVL GYV gein E E DL ERLEPA nyaggdy I GKSGIE KY YE DE L R G 198
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 185 KPG KTLI f KM N NK - KFLWNIQK V -- QK GKD IR L AL D SK LQQ KT E E AL rsqikkit DVNA G Y VVV T D VK TG A IL T M ANSAV 261
Cdd:TIGR03423 199 KPG YREV - EV N AR g RVIRTLSR V pp VP GKD LV L TI D AR LQQ AA E K AL -------- GGRR G A VVV M D PR TG E IL A M VSTPS 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 262 FDPN TLYEQV SSK ke NI K S L SQ ------- N K AIQ klkyge SYVNMA ST I KP LTI L IG L N E KLFQ PE DTYLDK G T FQ YDNQ 334
Cdd:TIGR03423 270 FDPN LFVDGI SSK -- DY K A L LN dpdrpll N R AIQ ------ GVYPPG ST F KP VVA L AA L E E GVIT PE TRIYCP G Y FQ LGGR 341
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 335 N - NITNAP G tp T G EITP R Q AI IN S SNTFMT a KV AL P L fnqnn G n I E K V A hiwt EY L K Q FG LRS KTG V DLP F E ED G qye FH 413
Cdd:TIGR03423 342 R f RCWKRG G -- H G RVDL R K AI EE S CDVYFY - QL AL R L ----- G - I D K I A ---- EY A K R FG FGQ KTG I DLP G E KS G --- LV 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 414 P T ----- NK F ENG -- ISAL LN A S W G - G NEVH TPLQLA QYA A T LA SK G DK YKP QILSA I I D QN G KETKKFK P ILESSNRYP 485
Cdd:TIGR03423 406 P S rewkr KR F GQP wy PGDT LN V S I G q G YVLV TPLQLA VAT A A LA NG G KL YKP HLVKS I E D PD G GVVRRTE P EVLRPLPIS 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 486 VKFWS VV QG GM SQNIEE -------- IKN LP FHV AGKTG ----------- ITG A PNEQ ER MIN H S LF I A Y AP TED P Q IAV S 546
Cdd:TIGR03423 486 PENLD VV RE GM RDVVNG pggtarra RLG LP YKM AGKTG taqvvslkqge KYD A EQIP ER LRD H A LF V A F AP YDN P K IAV A 565
570 580
....*....|....*....|....
gi 446825128 547 V VIPGSNSEKNI AA LVTSE I LEYW 570
Cdd:TIGR03423 566 V IVEHGGGGSSA AA PIARK I MDAY 589
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
241-568
1.45e-40
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 149.10
E-value: 1.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 241 G YV VV T D V KTG AI L T M ANSAVF DPN TLYEQV sskkeniksls Q N K A IQK lkyge S Y V n MA ST I KP L T I L IG L NEKLFQ P E 320
Cdd:pfam00905 1 G SA VV L D P KTG EV L A M VGKPSY DPN GFIGPL ----------- R N R A VTS ----- R Y E - PG ST F KP F T A L AA L DNGVLK P D 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 321 D T YL D KGTF Q YDNQ n N I TNAPGTPT G EI T P RQA IIN SSN TF M t A K V A LP L fnqnng NIE K vahi WTE YLK Q FG LRS KTG V 400
Cdd:pfam00905 64 E T IF D WPGK Q QGGK - S I GDWNQDQV G IG T L RQA LEY SSN WY M - Q K L A QK L ------ GAD K ---- LRS YLK K FG YGN KTG I 131
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 401 D LP F E ED G Q yefh P T NKF eng ISALLNASWG G NEV h TPLQ L AQ YA A TL A SK G DKYK P QILSA I I D QNGKETKKFK PI LE S 480
Cdd:pfam00905 132 G LP G E NA G Y ---- L T PYW --- LEGATASFGI G LTI - TPLQ Q AQ AY A AI A NG G KLVP P HLVKS I E D KVDPKVLNKL PI SK S 203
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 481 SNRYPVK - FWS VV QG G MSQNIEEI kn LPFH VAGKTG ---- ITGAPNEQERMINHSL F IA YAP TED P QI A VS V V I -- P GSN 553
Cdd:pfam00905 204 TAEKVKD m LRL VV ND G TGTGTAAV -- PGYK VAGKTG taqv AGPKGGGYYDGAQIGW F VG YAP ADN P KY A FA V L I dd P KRY 281
330
....*....|....*
gi 446825128 554 SEKNI AA LVTSE ILE 568
Cdd:pfam00905 282 YGGKV AA PIFKD ILE 296
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
31-549
2.89e-31
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 128.73
E-value: 2.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 31 IT IA T S sae RG K I S D Q NG VI LA T N KKVKS L YCTS nd EKV S N - Q D T SNT L AFFN qfsnefqh D ISAE DI KSQLQQSCKKQT 109
Cdd:PRK10795 63 VP IA P S --- RG I I Y D R NG TP LA L N RTIYQ L EMMP -- EKV D N l Q Q T LDA L RSVV -------- D LTDD DI AAFRKERARSRR 129
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 110 MND IP LYSDIN E SELT -- FI N KKKPNN V II K DEWI RYYP KHEVGSQL IGYV E -- ND LN ---------- SK Y GS --- V GK S 172
Cdd:PRK10795 130 FTS IP VKTNLT E VQVA rf AV N QYRFPG V EV K GYQR RYYP YGSALTHV IGYV S ki ND KD verldkegkl AN Y AA thd I GK L 209
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 173 GIE LQ YE ND L K GK P G KTLIFKM N NKKFLWNI -- Q KV Q K G K DI R L A LD S KLQQ kteealrs Q I KKITDVNAGY VVVTD VK T 250
Cdd:PRK10795 210 GIE RY YE DV L H GK T G YEEVEVN N RGRVIRQL he Q PP Q A G H DI Y L T LD L KLQQ -------- Y I ETLLAGSRAA VVVTD PR T 281
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 251 G A IL TMANSAVF DPN TLYEQV SSK ke NIKS L SQ ------- N K A I Q KL k Y GE syvnm AST I KP LTILIG L NEKLFQPEDTY 323
Cdd:PRK10795 282 G G IL ALVSTPSY DPN LFVDGI SSK -- DYSG L LN dpnrpli N R A T Q GV - Y PP ----- AST V KP YVAVSA L SAGVITRNTSL 353
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 324 L D K G TF Q Y dnqnnitna PG TPT ---------- G EITPRQAIIN S SN TF MT a K VA LPL fnqnng N I EKVA hiwt E YLKQ FG 393
Cdd:PRK10795 354 F D P G WW Q L --------- PG SEK ryrdwkkwgh G RLNVTKSLEE S AD TF FY - Q VA YDM ------ G I DRLS ---- E WMGK FG 413
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 394 LRSK TG V DL PF E ED G -------- Q YE F H ---- PTNKFEN GI SA llnaswg G NEVH TP L Q LAQYAA TL ASK G DKYK P QI L S 461
Cdd:PRK10795 414 YGHY TG I DL AE E RS G nmptrewk Q KR F K kpwy QGDTIPV GI GQ ------- G YWTA TP I Q MSKALM TL IND G IVKV P HL L M 486
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 462 AII d QN GK ETKKFK P ILESSNRYPVKF W SVVQG GM -------- SQNIEEIKNL P FHV A G K T G ITG ---- AP NE Q ------ 523
Cdd:PRK10795 487 STA - ED GK QVPWVQ P HEPPVGDIHSGY W EIAKD GM ygvanrpn GTAHKYFASA P YKI A A K S G TAQ vfgl KA NE T ynahki 565
570 580
....*....|....*....|....*..
gi 446825128 524 - ER MIN H S L FI A Y AP TED PQ I AV SVVI 549
Cdd:PRK10795 566 a ER LRD H K L MT A F AP YNN PQ V AV AIIL 592
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
30-570
1.45e-117
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 359.91
E-value: 1.45e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 30 S I TIATSS A E RG K I S D Q NG VI LATN KK V K SLY ctsndek VSNQDTSNTLAFFNQFSNEF qh DISA E DIKSQ L qqsc KK QT 109
Cdd:COG0768 51 R I RTVPIP A P RG L I Y D R NG NV LATN VP V Y SLY ------- ADPEEVKDPEETAEKLAKLL -- GLDP E ELRKK L ---- KK KS 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 110 MNDIP L YSDINES E LTF I NKK K PNN V IIKD E WI RYYP KH E VGSQLI GYV en DLNSKYGSV GKSG I E LQ YE ND L K G K PGK T 189
Cdd:COG0768 118 RFPVY L KRNLSPE E AAR I RAL K LPG V YVEA E YK RYYP YG E LAAHVL GYV -- GEINGGDGI GKSG L E KA YE DL L R G T PGK R 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 190 LIFKMNNKKFLWNIQKV --- QK GKD IR L AL DS K LQ QKT EEAL RSQIKK i TDVNA G Y VVV T D V KTG A IL T MA NSAV FDPN T 266
Cdd:COG0768 196 RVEVDARGRVIRDLGEE kpp VP GKD LV L TI DS D LQ KIA EEAL KKAVEE - YKAKS G A VVV M D P KTG E IL A MA SYPS FDPN L 274
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 267 LY eqvssk KENIKS L s Q N K A I Q klkyg ES Y V n MA ST I KP L T ILIG L N E KLFQ P ED T YLDK G TFQYDNQN n I TNAPGTPT G 346
Cdd:COG0768 275 FV ------ GGPDEP L - R N R A V Q ----- GT Y E - PG ST F KP F T AAAA L E E GVIT P DT T FDCP G YYRVGGRT - I RDWDRGGH G 340
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 347 EI T PRQ A IIN SSN TFM t A K V AL P L fnqnng N I E K vahi WTE YLK Q FGL RS KTG V DLP F E ED G Q ye FHPTNKF en GISALL 426
Cdd:COG0768 341 TL T LTE A LAK SSN VGF - Y K L AL R L ------ G I D K ---- LYD YLK K FGL GQ KTG I DLP G E AS G L -- LPSPKRW -- YPGETA 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 427 NA S W G - G NE V h TPLQLAQ YA A TL A SK G DKY KP QILSA I I D QN G KET K KFKPI L ES -- S NRY pvkf WSV V QG GM SQNIE E - 502
Cdd:COG0768 406 TM S I G q G LS V - TPLQLAQ AY A AI A NG G VLV KP HLVKE I V D PD G EVV K EEPEV L RR vi S PET ---- AET V RE GM EGVVN E p 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 503 ------ IKNLPFH VAGKTG ---- ITGAPNEQERMINHSL F IAY AP TED P QI AV S VV IPGSNSEKN --- I AA L V TS EI L E Y 569
Cdd:COG0768 481 ggtarr AAIPGYR VAGKTG taqv VDIGNGGYYKGRHIAS F VGF AP ADN P RY AV A VV VENPGGGAY ggt V AA P V FR EI M E A 560
.
gi 446825128 570 W 570
Cdd:COG0768 561 Y 561
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
38-570
8.01e-86
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 277.87
E-value: 8.01e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 38 AE RG K I S D Q NGV I LA T N KKVK SL YCTS nd EKV SNQ D tsntl A FFNQFSNEF qh D ISA EDI KSQ L QQSCKKQTMND IPL Y S 117
Cdd:TIGR03423 48 PP RG L I L D R NGV L LA D N RPSF SL EIVP -- EKV DDL D ----- A TLDRLAKLL -- D LDP EDI ARF L KELKRSRRFEP IPL K S 118
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 118 D IN E S E LTFINKKKPN -- N V I I KDEWI RYYP KH E VGSQLI GYV ---- E N DL NSKYGS ------- V GKSGIE LQ YE ND L K G 184
Cdd:TIGR03423 119 D LT E E E VARFAVNQYR lp G V E I EARLK RYYP YG E LAAHVL GYV gein E E DL ERLEPA nyaggdy I GKSGIE KY YE DE L R G 198
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 185 KPG KTLI f KM N NK - KFLWNIQK V -- QK GKD IR L AL D SK LQQ KT E E AL rsqikkit DVNA G Y VVV T D VK TG A IL T M ANSAV 261
Cdd:TIGR03423 199 KPG YREV - EV N AR g RVIRTLSR V pp VP GKD LV L TI D AR LQQ AA E K AL -------- GGRR G A VVV M D PR TG E IL A M VSTPS 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 262 FDPN TLYEQV SSK ke NI K S L SQ ------- N K AIQ klkyge SYVNMA ST I KP LTI L IG L N E KLFQ PE DTYLDK G T FQ YDNQ 334
Cdd:TIGR03423 270 FDPN LFVDGI SSK -- DY K A L LN dpdrpll N R AIQ ------ GVYPPG ST F KP VVA L AA L E E GVIT PE TRIYCP G Y FQ LGGR 341
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 335 N - NITNAP G tp T G EITP R Q AI IN S SNTFMT a KV AL P L fnqnn G n I E K V A hiwt EY L K Q FG LRS KTG V DLP F E ED G qye FH 413
Cdd:TIGR03423 342 R f RCWKRG G -- H G RVDL R K AI EE S CDVYFY - QL AL R L ----- G - I D K I A ---- EY A K R FG FGQ KTG I DLP G E KS G --- LV 405
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 414 P T ----- NK F ENG -- ISAL LN A S W G - G NEVH TPLQLA QYA A T LA SK G DK YKP QILSA I I D QN G KETKKFK P ILESSNRYP 485
Cdd:TIGR03423 406 P S rewkr KR F GQP wy PGDT LN V S I G q G YVLV TPLQLA VAT A A LA NG G KL YKP HLVKS I E D PD G GVVRRTE P EVLRPLPIS 485
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 486 VKFWS VV QG GM SQNIEE -------- IKN LP FHV AGKTG ----------- ITG A PNEQ ER MIN H S LF I A Y AP TED P Q IAV S 546
Cdd:TIGR03423 486 PENLD VV RE GM RDVVNG pggtarra RLG LP YKM AGKTG taqvvslkqge KYD A EQIP ER LRD H A LF V A F AP YDN P K IAV A 565
570 580
....*....|....*....|....
gi 446825128 547 V VIPGSNSEKNI AA LVTSE I LEYW 570
Cdd:TIGR03423 566 V IVEHGGGGSSA AA PIARK I MDAY 589
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
241-568
1.45e-40
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 149.10
E-value: 1.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 241 G YV VV T D V KTG AI L T M ANSAVF DPN TLYEQV sskkeniksls Q N K A IQK lkyge S Y V n MA ST I KP L T I L IG L NEKLFQ P E 320
Cdd:pfam00905 1 G SA VV L D P KTG EV L A M VGKPSY DPN GFIGPL ----------- R N R A VTS ----- R Y E - PG ST F KP F T A L AA L DNGVLK P D 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 321 D T YL D KGTF Q YDNQ n N I TNAPGTPT G EI T P RQA IIN SSN TF M t A K V A LP L fnqnng NIE K vahi WTE YLK Q FG LRS KTG V 400
Cdd:pfam00905 64 E T IF D WPGK Q QGGK - S I GDWNQDQV G IG T L RQA LEY SSN WY M - Q K L A QK L ------ GAD K ---- LRS YLK K FG YGN KTG I 131
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 401 D LP F E ED G Q yefh P T NKF eng ISALLNASWG G NEV h TPLQ L AQ YA A TL A SK G DKYK P QILSA I I D QNGKETKKFK PI LE S 480
Cdd:pfam00905 132 G LP G E NA G Y ---- L T PYW --- LEGATASFGI G LTI - TPLQ Q AQ AY A AI A NG G KLVP P HLVKS I E D KVDPKVLNKL PI SK S 203
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 481 SNRYPVK - FWS VV QG G MSQNIEEI kn LPFH VAGKTG ---- ITGAPNEQERMINHSL F IA YAP TED P QI A VS V V I -- P GSN 553
Cdd:pfam00905 204 TAEKVKD m LRL VV ND G TGTGTAAV -- PGYK VAGKTG taqv AGPKGGGYYDGAQIGW F VG YAP ADN P KY A FA V L I dd P KRY 281
330
....*....|....*
gi 446825128 554 SEKNI AA LVTSE ILE 568
Cdd:pfam00905 282 YGGKV AA PIFKD ILE 296
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
38-191
1.15e-34
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 128.98
E-value: 1.15e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 38 A E RG K I S D Q NGV I LATNK K V K SL YC T sn DE K VSNQ D TSN T LAFFNQFSN e FQH D ISA ED IKSQLQQSCKKQTMNDIPLYS 117
Cdd:pfam03717 4 A P RG E I Y D R NGV V LATNK P V Y SL TI T -- PS K LKKA D ALK T ALKLAKLLS - NYE D LDD ED LTERFLKMNSYKSYYPVVIKK 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 118 DIN E S E LTF I NKKKPN -- N V I I KDEWI RYYP KH E VGSQ L I GYV -------- E ND L NSK Y GS --- VGKSG I E L QYE ND L K G 184
Cdd:pfam03717 81 NLS E E E VAR I EENLLE lp G V S I ETDPV RYYP YG E LAAH L L GYV geiteeel E KY L DKG Y SR gdl VGKSG L E K QYE SV L R G 160
....*..
gi 446825128 185 K P G KTLI 191
Cdd:pfam03717 161 K D G VRQV 167
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
31-549
2.89e-31
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 128.73
E-value: 2.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 31 IT IA T S sae RG K I S D Q NG VI LA T N KKVKS L YCTS nd EKV S N - Q D T SNT L AFFN qfsnefqh D ISAE DI KSQLQQSCKKQT 109
Cdd:PRK10795 63 VP IA P S --- RG I I Y D R NG TP LA L N RTIYQ L EMMP -- EKV D N l Q Q T LDA L RSVV -------- D LTDD DI AAFRKERARSRR 129
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 110 MND IP LYSDIN E SELT -- FI N KKKPNN V II K DEWI RYYP KHEVGSQL IGYV E -- ND LN ---------- SK Y GS --- V GK S 172
Cdd:PRK10795 130 FTS IP VKTNLT E VQVA rf AV N QYRFPG V EV K GYQR RYYP YGSALTHV IGYV S ki ND KD verldkegkl AN Y AA thd I GK L 209
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 173 GIE LQ YE ND L K GK P G KTLIFKM N NKKFLWNI -- Q KV Q K G K DI R L A LD S KLQQ kteealrs Q I KKITDVNAGY VVVTD VK T 250
Cdd:PRK10795 210 GIE RY YE DV L H GK T G YEEVEVN N RGRVIRQL he Q PP Q A G H DI Y L T LD L KLQQ -------- Y I ETLLAGSRAA VVVTD PR T 281
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 251 G A IL TMANSAVF DPN TLYEQV SSK ke NIKS L SQ ------- N K A I Q KL k Y GE syvnm AST I KP LTILIG L NEKLFQPEDTY 323
Cdd:PRK10795 282 G G IL ALVSTPSY DPN LFVDGI SSK -- DYSG L LN dpnrpli N R A T Q GV - Y PP ----- AST V KP YVAVSA L SAGVITRNTSL 353
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 324 L D K G TF Q Y dnqnnitna PG TPT ---------- G EITPRQAIIN S SN TF MT a K VA LPL fnqnng N I EKVA hiwt E YLKQ FG 393
Cdd:PRK10795 354 F D P G WW Q L --------- PG SEK ryrdwkkwgh G RLNVTKSLEE S AD TF FY - Q VA YDM ------ G I DRLS ---- E WMGK FG 413
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 394 LRSK TG V DL PF E ED G -------- Q YE F H ---- PTNKFEN GI SA llnaswg G NEVH TP L Q LAQYAA TL ASK G DKYK P QI L S 461
Cdd:PRK10795 414 YGHY TG I DL AE E RS G nmptrewk Q KR F K kpwy QGDTIPV GI GQ ------- G YWTA TP I Q MSKALM TL IND G IVKV P HL L M 486
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 462 AII d QN GK ETKKFK P ILESSNRYPVKF W SVVQG GM -------- SQNIEEIKNL P FHV A G K T G ITG ---- AP NE Q ------ 523
Cdd:PRK10795 487 STA - ED GK QVPWVQ P HEPPVGDIHSGY W EIAKD GM ygvanrpn GTAHKYFASA P YKI A A K S G TAQ vfgl KA NE T ynahki 565
570 580
....*....|....*....|....*..
gi 446825128 524 - ER MIN H S L FI A Y AP TED PQ I AV SVVI 549
Cdd:PRK10795 566 a ER LRD H K L MT A F AP YNN PQ V AV AIIL 592
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
212-547
7.16e-25
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 108.85
E-value: 7.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 212 I RLA LD S KLQ QKT E E A LRSQI -- K K ITDVN A G y V VV T D V KTG AI L T M A nsavfdpntlyeqvsskkeniksls QNK aiqk 289
Cdd:COG0744 297 I YTT LD P KLQ KAA E K A VKNVL pe G K PGGLQ A A - L VV V D P KTG EV L A M V ------------------------- GGR ---- 346
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 290 l K YG E S YV N M A -------- ST I KP LTILIG L NEK l FQ P ED T YL D KGTFQYDNQNNIT N AP G TPT G EI T P R Q A II NS S NT f 361
Cdd:COG0744 347 - D YG K S QF N R A tqakrqpg ST F KP FVYAAA L EQG - YT P AT T VD D EPVTFPGGGWSPK N YD G RYR G PV T L R E A LA NS L NT - 423
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 362 mtak V A LP L FNQNN gn IE KV A hiwt EYLKQF G LR S K tgvdlpfeedgqyefhptnk FENGI S AL L nasw G GN EV h T PL QL 441
Cdd:COG0744 424 ---- P A VR L AQEVG -- LD KV V ---- DTARRL G IT S P -------------------- LDPNP S LA L ---- G TS EV - S PL EM 468
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 442 A QYA AT L A SK G DKYK P QILSAII D QN GK ETKKF KP il ESSNRYPVKFWSVVQGGMSQNIEE ------- IKNL P fh VAGKT 514
Cdd:COG0744 469 A SAY AT F A NG G VYVE P HAITKVT D AD GK VLYEA KP -- KCEQVISPEVAYLMTDMLQDVVTS gtgraar LPGR P -- VAGKT 544
330 340 350
....*....|....*....|....*....|...
gi 446825128 515 G I T gapn EQE R min HSL F IA Y apte D PQ IAVS V 547
Cdd:COG0744 545 G T T ---- NDN R --- DAW F VG Y ---- T PQ LVTA V 566
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
30-549
7.60e-21
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 96.43
E-value: 7.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 30 S ITIATS S AE RG K I S D QN G VI LA TNKK VK SLYC tsn D E K VSNQDTSNTL affnqfsn EFQHDIS A EDIKSQ L Q Q SCKKQT 109
Cdd:PRK15105 60 S LRVQEV S TS RG M I T D RS G RP LA VSVP VK AIWA --- D P K EVHDAGGISV -------- DDRWKAL A DALNIP L D Q LSARIN 128
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 110 M N D ---- I P L YSDI N ESELTF I N K K K PNNVIIKD E WI RYYP KH EV GSQ LIG YVEN D lnskyg S V G KS G I E LQYEND L K G K 185
Cdd:PRK15105 129 A N P kgrf I Y L ARQV N PDMADY I K K L K LPGIHLRE E SR RYYP SG EV TAH LIG FTNV D ------ S Q G IE G V E KSFDKW L T G Q 202
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 186 PG KTLIF K MNNKKFLWN I QKV -- Q KGKDIR L AL D SK LQ QKTEEA L RSQIK k ITDVNA G YV V VT DV K TG AI L T MANS AVFD 263
Cdd:PRK15105 203 PG ERIVR K DRYGRVIED I SST ds Q AAHNLA L SI D ER LQ ALVYRE L NNAVA - FNKAES G SA V LV DV N TG EV L A MANS PSYN 281
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 264 PN T L yeq VSSK K ENIK slsq N K AI QKL kygesy VNMA ST I KP LTILIG L NEKLFQ p E DTY L DKGTF q YD N QNN I TNAPGT 343
Cdd:PRK15105 282 PN N L --- SGTP K DAMR ---- N R AI TDV ------ FEPG ST V KP MVVMTA L QRGVVK - E NSV L NTVPY - RI N GHE I KDVARY 346
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 344 PTGEI T prq AIINS S NTFMTA K V AL PL fnqnngniek VAHIWTEYLKQ FGL RSK T GVD L PF E ED G Q Y efh P TNKFENG I S 423
Cdd:PRK15105 347 SELTL T --- GVLQK S SNVGVS K L AL AM ---------- PSSALVDTYSR FGL GKA T NLG L VG E RS G L Y --- P QKQRWSD I E 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 424 A l LNA S W G GNEVH TPLQLA QYA AT LA S K G d K Y K P QILSA i I D QNGKETKK F K pil ES SN R YP V KFWSV V Q ---- GG MSQN 499
Cdd:PRK15105 411 R - ATF S F G YGLMV TPLQLA RVY AT IG S Y G - I Y R P LSITK - V D PPVPGERV F P --- ES IV R TV V HMMES V A lpgg GG VKAA 484
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 446825128 500 I EE iknlp FHV A G KTG ITGAPNEQE R M IN H sl F IAY ---- AP TED P QI A VS VVI 549
Cdd:PRK15105 485 I KG ----- YRI A I KTG TAKKVGPDG R Y IN K -- Y IAY tagv AP ASQ P RF A LV VVI 531
PbpC
COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
201-452
2.08e-04
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain]
Cd Length: 773
Bit Score: 44.44
E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 201 WNIQKVQK G KD IR LA LD SK LQ QKT E EAL R SQIKKITD --- V NA G y V V V T D VK TG AI L TMAN SA V F D pntlyeqvsskken 277
Cdd:COG4953 263 RLLRQLPG G TR IR TT LD AG LQ RRL E RLV R RYVRRLKQ ngi H NA A - V L V V D NR TG EV L AYVG SA D F F -------------- 327
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 278 ikslsq NKAI Q K lkyges Y V N M A ------- ST I KP L ti L I GL -- NEK L FQ PE ---- D TYLDK G TFQ --- Y D NQNN itnap 341
Cdd:COG4953 328 ------ DASR Q G ------ Q V D M V ralrspg ST L KP F -- L Y GL al DQG L IH PE tlla D VPTSF G GYR pen F D GTFQ ----- 388
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446825128 342 gtpt G EITP R Q A IIN S S N T --- FMTAKVALPL F nqnngniekvahiw TEY L KQF GLR sktgvd L PFEEDGQ Y efhptnkf 418
Cdd:COG4953 389 ---- G PVSA R E A LAR S L N I pav RLLEALGPAR F -------------- YAR L RRA GLR ------ L LLPPAEH Y -------- 436
250 260 270
....*....|....*....|....*....|....*
gi 446825128 419 en G I S AL L nasw GG N EV h T PLQ L AQ - YAA t LA SK G 452
Cdd:COG4953 437 -- G L S LI L ---- GG A EV - T LEE L VG l YAA - LA RG G 463
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
