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Conserved domains on  [gi|446831860|ref|WP_000909116|]
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MULTISPECIES: putative quinol monooxygenase [Enterobacteriaceae]

Protein Classification

putative quinol monooxygenase( domain architecture ID 10003583)

monooxygenase similar to Escherichia coli quinol monooxygenase YgiN that can oxidize menadiol to menadione, may be an antibiotic biosynthesis monooxygenase involved in the biosynthesis of antibiotics, such as Streptomyces tetracenomycin-F1 monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  16496224
SCOP:  4000637

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
128-212 1.02e-14

Quinol monooxygenase YgiN [Energy production and conversion];


:

Pssm-ID: 440970  Cd Length: 91  Bit Score: 67.28  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446831860 128 LVIVEVKPEFQSEFRNIvLPEMVESLKVEKGVLAMYAGTDSETPKRWYFYEIYASEEDYQLHRQTLHFLDYLRQTAHMSA 207
Cdd:COG1359    4 IAKLTVKPGKRDEFLAA-LRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLA 82


                 ....*
gi 446831860 208 RKDAI 212
Cdd:COG1359   83 EPPEV 87
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
22-107 5.80e-09

Quinol monooxygenase YgiN [Energy production and conversion];


:

Pssm-ID: 440970  Cd Length: 91  Bit Score: 51.88  E-value: 5.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446831860  22 IFELGIRPDRDNDFADVARQTISASVdHEAGTLAMYALQRSDNSGQAFMFELYENERAYRKHLNAAPYKAFAARAPDIID 101
Cdd:COG1359    4 IAKLTVKPGKRDEFLAALRELVEATR-AEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLA 82


                 ....*.
gi 446831860 102 RKKKIT 107
Cdd:COG1359   83 EPPEVR 88
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
128-212 1.02e-14

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 67.28  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446831860 128 LVIVEVKPEFQSEFRNIvLPEMVESLKVEKGVLAMYAGTDSETPKRWYFYEIYASEEDYQLHRQTLHFLDYLRQTAHMSA 207
Cdd:COG1359    4 IAKLTVKPGKRDEFLAA-LRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLA 82


                 ....*
gi 446831860 208 RKDAI 212
Cdd:COG1359   83 EPPEV 87
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 131-198 4.15e-10

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 54.20  E-value: 4.15e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446831860  131 VEVKPEFQSEFRNIvLPEMVESLKVEKGVLAMYAGTDSETPKRWYFYEIYASEEDYQLHRQTLHFLDY 198
Cdd:pfam03992   7 IRVKPGKAEEFEEA-LAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAA 73
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
22-107 5.80e-09

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 51.88  E-value: 5.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446831860  22 IFELGIRPDRDNDFADVARQTISASVdHEAGTLAMYALQRSDNSGQAFMFELYENERAYRKHLNAAPYKAFAARAPDIID 101
Cdd:COG1359    4 IAKLTVKPGKRDEFLAALRELVEATR-AEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLA 82


                 ....*.
gi 446831860 102 RKKKIT 107
Cdd:COG1359   83 EPPEVR 88
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 22-93 4.00e-07

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 46.11  E-value: 4.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446831860   22 IFELGIRPDRDNDFADVARQTISASVDhEAGTLAMYALQRSDNSGQAFMFELYENERAYRKHLNAAPYKAFA 93
Cdd:pfam03992   4 VAEIRVKPGKAEEFEEALAELVEATRN-EPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
128-196 3.14e-04

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 38.94  E-value: 3.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446831860 128 LVIVEVKPEFQSEFRNIVLPEMVESLKvEKGVLAMYAGTDSETPKRWYFYEIYASEEDYQLHRQTLHFL 196
Cdd:PRK10486   5 LVEINVKEDKVDEFIEVFRQNHLGSIQ-EPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYK 72
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
128-212 1.02e-14

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 67.28  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446831860 128 LVIVEVKPEFQSEFRNIvLPEMVESLKVEKGVLAMYAGTDSETPKRWYFYEIYASEEDYQLHRQTLHFLDYLRQTAHMSA 207
Cdd:COG1359    4 IAKLTVKPGKRDEFLAA-LRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLA 82


                 ....*
gi 446831860 208 RKDAI 212
Cdd:COG1359   83 EPPEV 87
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 131-198 4.15e-10

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 54.20  E-value: 4.15e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446831860  131 VEVKPEFQSEFRNIvLPEMVESLKVEKGVLAMYAGTDSETPKRWYFYEIYASEEDYQLHRQTLHFLDY 198
Cdd:pfam03992   7 IRVKPGKAEEFEEA-LAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAA 73
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
22-107 5.80e-09

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 51.88  E-value: 5.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446831860  22 IFELGIRPDRDNDFADVARQTISASVdHEAGTLAMYALQRSDNSGQAFMFELYENERAYRKHLNAAPYKAFAARAPDIID 101
Cdd:COG1359    4 IAKLTVKPGKRDEFLAALRELVEATR-AEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPLLA 82


                 ....*.
gi 446831860 102 RKKKIT 107
Cdd:COG1359   83 EPPEVR 88
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 22-93 4.00e-07

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 46.11  E-value: 4.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446831860   22 IFELGIRPDRDNDFADVARQTISASVDhEAGTLAMYALQRSDNSGQAFMFELYENERAYRKHLNAAPYKAFA 93
Cdd:pfam03992   4 VAEIRVKPGKAEEFEEALAELVEATRN-EPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
128-196 3.14e-04

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 38.94  E-value: 3.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446831860 128 LVIVEVKPEFQSEFRNIVLPEMVESLKvEKGVLAMYAGTDSETPKRWYFYEIYASEEDYQLHRQTLHFL 196
Cdd:PRK10486   5 LVEINVKEDKVDEFIEVFRQNHLGSIQ-EPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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