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Conserved domains on  [gi|446838826|ref|WP_000916082|]
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MULTISPECIES: hydrogenase 4 subunit H [Enterobacteriaceae]

Protein Classification

PRK08222 family protein( domain architecture ID 11483168)

PRK08222 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 1-179 3.39e-107

hydrogenase 4 subunit H; Validated


:

Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 303.98  E-value: 3.39e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGAC--ACPANALTIQTDDQQNSRTWQLYLRRCIYCGR 78
Cdd:PRK08222   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGACtcACPANALTIQTDDQQNSRTWQLYLGRCIYCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  79 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQQQNAPQNREMLRAQASVCPEC 158
Cdd:PRK08222  81 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQQQNAPQNREMLRAQASVCPEC 160

                        170       180
                 ....*....|....*....|.
gi 446838826 159 KQRATLINDDTDVPLVAKEQL 179
Cdd:PRK08222 161 KQRATLINDDTDVPLVAKEQL 181
 
Name Accession Description Interval E-value
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 1-179 3.39e-107

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 303.98  E-value: 3.39e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGAC--ACPANALTIQTDDQQNSRTWQLYLRRCIYCGR 78
Cdd:PRK08222   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGACtcACPANALTIQTDDQQNSRTWQLYLGRCIYCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  79 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQQQNAPQNREMLRAQASVCPEC 158
Cdd:PRK08222  81 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQQQNAPQNREMLRAQASVCPEC 160

                        170       180
                 ....*....|....*....|.
gi 446838826 159 KQRATLINDDTDVPLVAKEQL 179
Cdd:PRK08222 161 KQRATLINDDTDVPLVAKEQL 181
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 15-104 4.22e-22

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 85.93  E-value: 4.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   15 TVKYPFAPLEVSPGFRG-----KPDLMPSQCIACGACA--CPANALTIQT----DDQQNSRTWQLYLRRCIYCGRCEEVC 83
Cdd:TIGR01971  15 TVQYPEEKLYLPPRFRGrivltRDPNGEEKCIGCTLCAavCPADAIRVVPaegeDGKRRLKFYEINFGRCIFCGLCEEAC 94

                          90       100
                  ....*....|....*....|.
gi 446838826   84 PTRAIQLTNNFELTVTNKADL 104
Cdd:TIGR01971  95 PTDAIVLTPEFELATYTRSDL 115
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 37-103 2.32e-15

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 67.08  E-value: 2.32e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446838826  37 PSQCIACGAC--ACPANALTIqtDDQQNSRTWQLYLRRCIYCGRCEEVCPTRAIQLTnNFELTVTNKAD 103
Cdd:COG1143    1 EDKCIGCGLCvrVCPVDAITI--EDGEPGKVYVIDPDKCIGCGLCVEVCPTGAISMT-PFELAVEDREE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 37-98 4.00e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 57.41  E-value: 4.00e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446838826  37 PSQCIACGAC--ACPANALTIQTDDQqNSRTWQLYLRRCIYCGRCEEVCPTRAIQLTNNFELTV 98
Cdd:cd10549    5 PEKCIGCGICvkACPTDAIELGPNGA-IARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYV 67
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 40-87 6.55e-08

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 47.14  E-value: 6.55e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446838826   40 CIACGAC--ACPANALTIQTDDQQN-SRTWQLYLRRCIYCGRCEEVCPTRA 87
Cdd:pfam12838   1 CIGCGACvaACPVGAITLDEVGEKKgTKTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 40-89 8.41e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 44.46  E-value: 8.41e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446838826  40 CIACGACA--CPANALTIQtddqqNSR-TWQlylRRCIYCGRCEEVCPTRAIQ 89
Cdd:NF038196 187 CIGCGICAkvCPVNNIEME-----DGKpVWG---HNCTHCLACIHRCPKEAIE 231
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 72-93 3.62e-04

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 39.84  E-value: 3.62e-04
                         10        20
                 ....*....|....*....|..
gi 446838826  72 RCIYCGRCEEVCPTRAIQLTNN 93
Cdd:NF038196 186 KCIGCGICAKVCPVNNIEMEDG 207
 
Name Accession Description Interval E-value
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 1-179 3.39e-107

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 303.98  E-value: 3.39e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGAC--ACPANALTIQTDDQQNSRTWQLYLRRCIYCGR 78
Cdd:PRK08222   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGACtcACPANALTIQTDDQQNSRTWQLYLGRCIYCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  79 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQQQNAPQNREMLRAQASVCPEC 158
Cdd:PRK08222  81 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQQQNAPQNREMLRAQASVCPEC 160

                        170       180
                 ....*....|....*....|.
gi 446838826 159 KQRATLINDDTDVPLVAKEQL 179
Cdd:PRK08222 161 KQRATLINDDTDVPLVAKEQL 181
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 1-169 5.26e-76

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 225.30  E-value: 5.26e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGAC--ACPANALTIQTDDQQNSRTWQLYLRRCIYCGR 78
Cdd:PRK12387   1 MFKLIKKVIKTGTATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACvnACPSNALTVETDLATGELAWEFNLGRCIFCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  79 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLaqQQNAPQNREMLRAQASVCPEC 158
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQQSEFALCNCRVCGRPFAVQKEIDYAIALL--KHNGDSRAENHRESFETCPEC 158

                        170
                 ....*....|.
gi 446838826 159 KQRATLINDDT 169
Cdd:PRK12387 159 KRQKCLVPSDR 169
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
14-105 3.22e-29

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 105.73  E-value: 3.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  14 ATVKYPFAPLEVSPGFRGKPDLMP-----SQCIACGACA--CPANALTIQTDDQQNSR----TWQLYLRRCIYCGRCEEV 82
Cdd:PRK05888  29 VTIQYPEEKLPLSPRFRGRHALRRdpngeERCIACKLCAaiCPADAITIEAAEREDGRrrttRYDINFGRCIFCGFCEEA 108

                         90       100
                 ....*....|....*....|...
gi 446838826  83 CPTRAIQLTNNFELTVTNKADLY 105
Cdd:PRK05888 109 CPTDAIVETPDFELATETREELI 131
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 15-104 4.22e-22

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 85.93  E-value: 4.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   15 TVKYPFAPLEVSPGFRG-----KPDLMPSQCIACGACA--CPANALTIQT----DDQQNSRTWQLYLRRCIYCGRCEEVC 83
Cdd:TIGR01971  15 TVQYPEEKLYLPPRFRGrivltRDPNGEEKCIGCTLCAavCPADAIRVVPaegeDGKRRLKFYEINFGRCIFCGLCEEAC 94

                          90       100
                  ....*....|....*....|.
gi 446838826   84 PTRAIQLTNNFELTVTNKADL 104
Cdd:TIGR01971  95 PTDAIVLTPEFELATYTRSDL 115
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 37-103 2.32e-15

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 67.08  E-value: 2.32e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446838826  37 PSQCIACGAC--ACPANALTIqtDDQQNSRTWQLYLRRCIYCGRCEEVCPTRAIQLTnNFELTVTNKAD 103
Cdd:COG1143    1 EDKCIGCGLCvrVCPVDAITI--EDGEPGKVYVIDPDKCIGCGLCVEVCPTGAISMT-PFELAVEDREE 66
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 1-103 3.94e-12

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 60.23  E-value: 3.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   1 MLKLLKTIMRAGT---ATVKYPFA-PLEVSPGFRGKPDLMPSQCIACGAC--ACPANALtIQTDDQQNSRTWqlyLRRCI 74
Cdd:PRK08348   1 RLPLLPTVLRNLFkkpATNLFPATePVPVPEDFRGKILYDVDKCVGCRMCvtVCPAGVF-VYLPEIRKVALW---TGRCV 76

                         90       100
                 ....*....|....*....|....*....
gi 446838826  75 YCGRCEEVCPTRAIQLTNNFELTVTNKAD 103
Cdd:PRK08348  77 FCGQCVDVCPTGALQMSDDFLLASYDRFD 105
ndhI CHL00014
NADH dehydrogenase subunit I
 15-104 3.35e-11

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 58.62  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  15 TVKYPFAPLEVSPGFRGKPDLMPSQCIACGAC--ACPANALTIQTDDQQNSRTWQLY-----LRRCIYCGRCEEVCPTRA 87
Cdd:CHL00014  36 TIQYPYEKLITSERFRGRIHFEFDKCIACEVCvrVCPIDLPVVDWKLETDIRKKRLLnysidFGVCIFCGNCVEYCPTNC 115

                         90
                 ....*....|....*..
gi 446838826  88 IQLTNNFELTVTNKADL 104
Cdd:CHL00014 116 LSMTEEYELSTYDRHEL 132
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 37-98 4.00e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 57.41  E-value: 4.00e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446838826  37 PSQCIACGAC--ACPANALTIQTDDQqNSRTWQLYLRRCIYCGRCEEVCPTRAIQLTNNFELTV 98
Cdd:cd10549    5 PEKCIGCGICvkACPTDAIELGPNGA-IARGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYV 67
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
31-95 9.21e-10

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 52.43  E-value: 9.21e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446838826  31 GKPDLMPSQCIACGACA--CPANALTIQTDdqqnsrTWQLYLRRCIYCGRCEEVCPTRAIQLTNNFE 95
Cdd:COG2768    4 GKPYVDEEKCIGCGACVkvCPVGAISIEDG------KAVIDPEKCIGCGACIEVCPVGAIKIEWEED 64
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 30-90 1.17e-09

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 52.04  E-value: 1.17e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446838826  30 RGKPDLMPSQCIACGACA--CPANALTIQtddqqNSRTWQLYLRRCIYCGRCEEVCPTRAIQL 90
Cdd:COG1149    3 RKIPVIDEEKCIGCGLCVevCPEGAIKLD-----DGGAPVVDPDLCTGCGACVGVCPTGAITL 60
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 40-98 1.30e-09

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 53.55  E-value: 1.30e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446838826  40 CIACGACA--CPANALTIQTDDQQNSRTWQ---LYLRRCIYCGRCEEVCPTRAIQLTNNFELTV 98
Cdd:cd10549   42 CVFCGACVevCPTGAIELTPEGKEYVPKEKeaeIDEEKCIGCGLCVKVCPVDAITLEDELEIVI 105
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 37-88 2.32e-08

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 48.55  E-value: 2.32e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446838826  37 PSQCIACGAC--ACPANALTIQTDDQqnsRTWQLYLRRCIYCGRCEEVCPTRAI 88
Cdd:COG1146    7 TDKCIGCGACveVCPVDVLELDEEGK---KALVINPEECIGCGACELVCPVGAI 57
NapF COG1145
Ferredoxin [Energy production and conversion];
37-93 6.11e-08

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 50.88  E-value: 6.11e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446838826  37 PSQCIACGAC--ACPANALTIQtddqQNSRTWQLYLRRCIYCGRCEEVCPTRAIQLTNN 93
Cdd:COG1145  181 AEKCIGCGLCvkVCPTGAIRLK----DGKPQIVVDPDKCIGCGACVKVCPVGAISLEPK 235
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 40-87 6.55e-08

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 47.14  E-value: 6.55e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446838826   40 CIACGAC--ACPANALTIQTDDQQN-SRTWQLYLRRCIYCGRCEEVCPTRA 87
Cdd:pfam12838   1 CIGCGACvaACPVGAITLDEVGEKKgTKTVVIDPERCVGCGACVAVCPTGA 51
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 32-88 1.11e-07

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 46.97  E-value: 1.11e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446838826  32 KPDLMPSQCIACGAC--ACPANALTIQTDdqqnsrTWQLYLRRCIYCGRCEEVCPTRAI 88
Cdd:COG2221    9 PPKIDEEKCIGCGLCvaVCPTGAISLDDG------KLVIDEEKCIGCGACIRVCPTGAI 61
PRK13984 PRK13984
putative oxidoreductase; Provisional
 15-94 2.19e-07

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 49.77  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  15 TVKYPFAPLEVSPGFRG--KPDLmpSQCIACGACA--CPANALT-IQTDD--QQNSRTWQ---LYLRRCIYCGRCEEVCP 84
Cdd:PRK13984  22 TIKVPNVKREAAERYRGfhINDW--EKCIGCGTCSkiCPTDAITmVEVPDlpQEYGKKPQrpvIDYGRCSFCALCVDICT 99

                         90
                 ....*....|
gi 446838826  85 TRAIQLTNNF 94
Cdd:PRK13984 100 TGSLKMTREY 109
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
30-104 4.27e-07

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 46.96  E-value: 4.27e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446838826  30 RGKPDLMPSQCIAC--GACA--CPANALTIQTDdqqnsrTWQLYLRRCIYCGRCEEVCPTRAIQLTNNFELTVTNKADL 104
Cdd:COG1142   42 RKAGVSAPVQCRHCedAPCAevCPVGAITRDDG------AVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAVAVKCDL 114
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 40-91 5.09e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 46.62  E-value: 5.09e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446838826  40 CIACGAC--ACPANALTIQTD-----DQQnsrtwqlylrRCIYCGRCEEVCPTRAIQLT 91
Cdd:cd10549   80 CIGCGLCvkVCPVDAITLEDEleiviDKE----------KCIGCGICAEVCPVNAIKLV 128
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
37-95 1.24e-06

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 47.33  E-value: 1.24e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446838826  37 PSQCIACGAC--ACPANAltIQTDDQQNSrtwqLYLRRCIYCGRCEEVCPTRAIQLTNNFE 95
Cdd:COG4624   90 KEKCKNCYPCvrACPVKA--IKVDDGKAE----IDEEKCISCGQCVAVCPFGAITEKSDIE 144
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
37-95 1.37e-06

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 46.98  E-value: 1.37e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446838826  37 PSQCIACGAC--ACPANAltiqtdDQQNSRTWQLylrRCIYCGRCEEVCPTRAIQLTNNFE 95
Cdd:COG0348  209 RGDCIDCGLCvkVCPMGI------DIRKGEINQS---ECINCGRCIDACPKDAIRFSSRGE 260
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 37-90 1.58e-06

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 43.88  E-value: 1.58e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  37 PSQCIACGAC--ACPANALTIQTD----DQqnsrtwqlylRRCIYCGRCEEVCPTRAIQL 90
Cdd:COG4231   21 EDKCTGCGACvkVCPADAIEEGDGkaviDP----------DLCIGCGSCVQVCPVDAIKL 70
PRK09898 PRK09898
ferredoxin-like protein;
38-98 2.30e-06

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 45.98  E-value: 2.30e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446838826  38 SQCIACGAC--ACPANALTIQTDDQQNSRtwqlylrrCIYCGRCEEVCPTRAIQLTNNFELTV 98
Cdd:PRK09898 154 KRCIGCSACttACPWMMATVNTESKKSSK--------CVLCGECANACPTGALKIIEWKDITV 208
Rama_corrin_act TIGR04270
methylamine methyltransferase corrinoid protein reductive activase; Members of this family ...
 38-94 2.37e-06

methylamine methyltransferase corrinoid protein reductive activase; Members of this family occur as paralogs in species capable of generating methane from mono-, di-, and tri-methylamine. Members include RamA (Reductive Activation of Methyltransfer, Amines) from Methanosarcina barkeri MS (DSM 800). Member proteins have two C-terminal motifs with four Cys each, likely to bind one 4Fe-4S cluster per motif.


Pssm-ID: 211993 [Multi-domain]  Cd Length: 535  Bit Score: 46.68  E-value: 2.37e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446838826   38 SQCIACGACA--CPANALTIQTDDQQNSRTwqlylRRCI--YCGRCEEVCPTRAIQLTNNF 94
Cdd:TIGR04270 479 EGCIACQKCVkeCPGKALSILESEPPRIDT-----DRCLgtACRRCERVCPEKVFDIRNFF 534
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 32-90 2.58e-06

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 43.50  E-value: 2.58e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446838826  32 KPDLMPSQCIACGAC--ACPANALTIQtddqqNSRTWQLYLRRCIYCGRCEEVCPTRAIQL 90
Cdd:COG1144   24 RPVVDEDKCIGCGLCwiVCPDGAIRVD-----DGKYYGIDYDYCKGCGICAEVCPVKAIEM 79
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
19-93 2.72e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 46.08  E-value: 2.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  19 PFAPLEVSPGFrgkPDLMPSQCIACGAC--ACPANALTIQTDDQQ-----NSRTWQLYLRR-----CIYCGRCEEVCPTR 86
Cdd:PRK07118 152 PFDAIHIENGL---PVVDEDKCTGCGACvkACPRNVIELIPKSARvfvacNSKDKGKAVKKvcevgCIGCGKCVKACPAG 228


                 ....*..
gi 446838826  87 AIQLTNN 93
Cdd:PRK07118 229 AITMENN 235
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
40-93 5.98e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 44.92  E-value: 5.98e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  40 CIACGAC--ACPANALTIQTD----DQQnsrtwqlylrRCIYCGRCEEVCPTRAIQLTNN 93
Cdd:PRK07118 215 CIGCGKCvkACPAGAITMENNlaviDQE----------KCTSCGKCVEKCPTKAIRILNK 264
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 40-89 8.41e-06

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 44.46  E-value: 8.41e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446838826  40 CIACGACA--CPANALTIQtddqqNSR-TWQlylRRCIYCGRCEEVCPTRAIQ 89
Cdd:NF038196 187 CIGCGICAkvCPVNNIEME-----DGKpVWG---HNCTHCLACIHRCPKEAIE 231
PRK13795 PRK13795
hypothetical protein; Provisional
 38-84 9.65e-06

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 44.99  E-value: 9.65e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446838826  38 SQCIACGAC--ACPANALTIQtddqQNSRTWQLYLRRCIYCGRCEEVCP 84
Cdd:PRK13795 581 AECVGCGVCvgACPTGAIRIE----EGKRKISVDEEKCIHCGKCTEVCP 625
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
9-92 1.83e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 44.08  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826   9 MRAGTATVKypfAPLEVSPGFrgkPDLMPSQCIACGAC--ACPANALTIqtDDQQNSRTWQLylrRCIYCGRCEEVCPTR 86
Cdd:COG1148  473 ARAIQLLSK---GELGVEPSV---AEVDPEKCTGCGRCveVCPYGAISI--DEKGVAEVNPA---LCKGCGTCAAACPSG 541


                 ....*.
gi 446838826  87 AIQLTN 92
Cdd:COG1148  542 AISLKG 547
Fer4_9 pfam13187
4Fe-4S dicluster domain;
39-88 2.33e-05

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 40.23  E-value: 2.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446838826   39 QCIACGAC--ACPANALTIQTDDQQNSRTWQLYlrRCIYCGRCEEVCPTRAI 88
Cdd:pfam13187   1 KCTGCGACvaACPAGAIVPDLVGQTIRGDIAGL--ACIGCGACVDACPRGAI 50
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 40-94 4.04e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 42.82  E-value: 4.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446838826  40 CIACGAC--ACPANALTIQ----TDDQQNSRTWQLYLRRCIYCGRCEEVCPTRaIQLTNNF 94
Cdd:COG4656  366 CIRCGRCvdACPMGLLPQQlywyARAGDFDKAEEYNLMDCIECGCCSYVCPSK-IPLVQYI 425
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 38-85 8.38e-05

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 42.01  E-value: 8.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446838826  38 SQCIACGAC--ACP-------ANALTIQTDDQQNSRTWQlylrRCIYCGRCEEVCPT 85
Cdd:cd01916  365 AKCTDCGWCtrACPnslrikeAMEAAKEGDFSGLADLFD----QCVGCGRCEQECPK 417
PRK13984 PRK13984
putative oxidoreductase; Provisional
 72-118 1.06e-04

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 41.68  E-value: 1.06e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446838826  72 RCIYCGRCEEVCPTRAIQLTNNFELTvTNKADLYTRATFHLQRCSRC 118
Cdd:PRK13984  46 KCIGCGTCSKICPTDAITMVEVPDLP-QEYGKKPQRPVIDYGRCSFC 91
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 38-165 1.07e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 41.94  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446838826  38 SQCIACGAC-------ACPANALTIQTDdqqnsrTWQLYLRRCIYCGRCEEVCPTRAIQLTNNfeltVTNKADLYTRATF 110
Cdd:PRK12809  51 ANPVACHHCnnapcvtACPVNALTFQSD------SVQLDEQKCIGCKRCAIACPFGVVEMVDT----IAQKCDLCNQRSS 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446838826 111 HLQRC-SRCerpfaPQKTVALAAELLAQQQNAPQNREMLRAQASVCPECKQRATLI 165
Cdd:PRK12809 121 GTQACiEVC-----PTQALRLMDDKGLQQIKVARQRKTAAGKASSDAQPSRSAALL 171
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 19-90 1.17e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 39.95  E-value: 1.17e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446838826  19 PFAPLEVSPGfrGKPDLMPSQCIACGAC--ACPANAltIQTDDQQNsrtwqlYLRRCIYCGRCEEVCPTRAIQL 90
Cdd:cd16370   66 PTGALEPRKG--GGVVLDKEKCIGCGNCvkACIVGA--IFWDEETN------KPIICIHCGYCARYCPHDVLAM 129
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 32-90 1.48e-04

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 41.14  E-value: 1.48e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446838826  32 KPDLMPSQCIACGAC--ACPANALTIQTDDQQNSRTWQLYLR-------RCIYCGRCEEVCPTRAIQL 90
Cdd:PRK14028 241 KPVIDHSKCIMCRKCwlYCPDDAIIEAWREAEGPRGRKFRMKmidfdyqYCKGCGVCAEVCPTGAIQM 308
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 72-98 2.42e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 37.79  E-value: 2.42e-04
                         10        20
                 ....*....|....*....|....*..
gi 446838826  72 RCIYCGRCEEVCPTRAIQLTNNFELTV 98
Cdd:COG1149   12 KCIGCGLCVEVCPEGAIKLDDGGAPVV 38
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 37-84 2.64e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 37.62  E-value: 2.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446838826   37 PSQCIACGAC--ACPANaLTIQTDDQQNSRTWQLY--LRRCIYCGRCEEVCP 84
Cdd:pfam13237   6 PDKCIGCGRCtaACPAG-LTRVGAIVERLEGEAVRigVWKCIGCGACVEACP 56
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 40-84 2.87e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 40.32  E-value: 2.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446838826  40 CIACGAC--ACPANALTIQ----TDDQQNSRTWQLYLRRCIYCGRCEEVCP 84
Cdd:PRK05035 372 CIRCGACadACPASLLPQQlywfAKAEEHDKAQEYNLFDCIECGACAYVCP 422
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 72-93 3.62e-04

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 39.84  E-value: 3.62e-04
                         10        20
                 ....*....|....*....|..
gi 446838826  72 RCIYCGRCEEVCPTRAIQLTNN 93
Cdd:NF038196 186 KCIGCGICAKVCPVNNIEMEDG 207
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-89 4.72e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 38.78  E-value: 4.72e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446838826  40 CIACGAC--ACPANALTIQTDDQ--QNSRTWQLYLRR--CIYCG-RCEEVCPTRAIQ 89
Cdd:cd16373   16 CIRCGLCveACPTGVIQPAGLEDglEGGRTPYLDPREgpCDLCCdACVEVCPTGALR 72
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 72-118 5.24e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 36.95  E-value: 5.24e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446838826  72 RCIYCGRCEEVCPTRAIQLTNNfeltvtnkadlytRATFHLQRCSRC 118
Cdd:COG2221   16 KCIGCGLCVAVCPTGAISLDDG-------------KLVIDEEKCIGC 49
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 24-88 5.65e-04

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 37.62  E-value: 5.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446838826   24 EVSPGFRGKPDLMPSQCIACGAC--ACPANALTIQtddQQNSRTWQLYLRRCIYCGRCEEVCPTRAI 88
Cdd:TIGR00402  20 QIRPPWSARESLFSAVCTRCGECasACENNILQLG---QQGQPTVEFDNAECDFCGKCAEACPTNAF 83
sulfite_red_A TIGR02910
sulfite reductase, subunit A; Members of this protein family include the A subunit, one of ...
 62-85 6.42e-04

sulfite reductase, subunit A; Members of this protein family include the A subunit, one of three subunits, of the anaerobic sulfite reductase of Salmonella, and close homologs from various Clostridum species, where the three-gene neighborhood is preserved. Two such gene clusters are found in Clostridium perfringens, but it may be that these sets of genes correspond to the distinct assimilatory and dissimilatory forms as seen in Clostridium pasteurianum. Note that any one of these enzymes may have secondary substates such as NH2OH, SeO3(2-), and SO3(2-). Heterologous expression of the anaerobic sulfite reductase of Salmonella confers on Escherichia coli the ability to produce hydrogen sulfide gas from sulfite. [Central intermediary metabolism, Sulfur metabolism]


Pssm-ID: 131956  Cd Length: 334  Bit Score: 39.43  E-value: 6.42e-04
                          10        20
                  ....*....|....*....|....
gi 446838826   62 NSRTWQLYLRRCIYCGRCEEVCPT 85
Cdd:TIGR02910 211 RSDFWDEYDSRCIACGRCNTVCPT 234
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 72-89 9.68e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 35.30  E-value: 9.68e-04
                          10
                  ....*....|....*...
gi 446838826   72 RCIYCGRCEEVCPTRAIQ 89
Cdd:pfam00037   7 KCIGCGACVEVCPVGAIT 24
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 39-84 1.08e-03

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 38.52  E-value: 1.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446838826  39 QCIACGAC--ACPANALT-----------------IQTDDQQN-SRTWQLYLRRCIYCGRCEEVCP 84
Cdd:COG0247   79 ACVGCGFCraMCPSYKATgdekdsprgrinllrevLEGELPLDlSEEVYEVLDLCLTCKACETACP 144
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 38-90 1.31e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 36.93  E-value: 1.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446838826  38 SQCIACGAC--ACPANALtIQTDDQQNSRtwqlylrRCIYCGRCEEVCPTRAIQL 90
Cdd:cd16372   77 KLCVGCLMCvgFCPEGAM-FKHEDYPEPF-------KCIACGICVKACPTGALEL 123
PRK06273 PRK06273
ferredoxin; Provisional
 40-84 1.97e-03

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 37.00  E-value: 1.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446838826  40 CIACGACA--CPANALTIQ-------TDDQQNSRTWQLYLRRCIYCGRCEEVCP 84
Cdd:PRK06273  51 CIGCGGCAnvCPTKAIEMIpvepvkiTEGYVKTKIPKIDYEKCVYCLYCHDFCP 104
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
31-61 4.06e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.93  E-value: 4.06e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 446838826  31 GKPDLMPSQCIACGAC--ACPANALTIQTDDQQ 61
Cdd:COG4624  113 GKAEIDEEKCISCGQCvaVCPFGAITEKSDIEK 145
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 70-90 4.29e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 36.08  E-value: 4.29e-03
                         10        20
                 ....*....|....*....|.
gi 446838826  70 LRRCIYCGRCEEVCPTRAIQL 90
Cdd:cd16373   13 LALCIRCGLCVEACPTGVIQP 33
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 40-90 4.65e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 36.78  E-value: 4.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446838826  40 CIACGAC--------ACPANALTiqtdDQQNSRTWQLYLRRCIYCGRCEEVCPTRAIQL 90
Cdd:PRK12771 506 CLSCGNCfecdncygACPQDAII----KLGPGRRYHFDYDKCTGCHICADVCPCGAIEM 560
napH_ TIGR02163
ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, ...
 38-92 5.45e-03

ferredoxin-type protein, NapH/MauN family; Most members of this family are the NapH protein, found next to NapG,in operons that encode the periplasmic nitrate reductase. Some species with this reductase lack NapC but accomplish electron transfer to NapAB in some other manner, likely to involve NapH, NapG, and/or some other protein. A few members of this protein are designated MauN and are found in methylamine utilization operons in species that appear to lack a periplasmic nitrate reductase.


Pssm-ID: 274004 [Multi-domain]  Cd Length: 255  Bit Score: 36.17  E-value: 5.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446838826   38 SQCIACGAC--ACPANALTIQTDDQQNSRtwQLYLRRCIYCGRCEEVCPTRAIQLTN 92
Cdd:TIGR02163 201 EKCTNCMDCfnVCPEPQVLRMPLKKGGST--LVLSGDCTLCGRCIDVCHEDVLGFTT 255
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
34-84 5.94e-03

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 36.34  E-value: 5.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446838826  34 DLMPSQCIACGACA-CPANA----------LTIQTDDQQNSR-TWQLYLR-----RCIYCGRCEEVCP 84
Cdd:COG1453  277 ELLKDFCTGCGYCMpCPQGInipevfrlynLARAYGMREYAKeRYNALGPgakasACIECGACEERCP 344
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 37-89 8.32e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 35.31  E-value: 8.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446838826  37 PSQCIACGAC--ACPANALTIQTDDQQnsrtwqlyLRRCIYCG---------RCEEVCPTRAIQ 89
Cdd:COG0437   89 YDKCIGCRYCvaACPYGAPRFNPETGV--------VEKCTFCAdrldegllpACVEACPTGALV 144
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 37-88 9.93e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 34.92  E-value: 9.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446838826  37 PSQCIA------CGAC--ACPANALTIQTDDQqnSRTWQLYLRRCIYCGRCEEVCPT---RAI 88
Cdd:cd16373   90 KDRCLAwqggtdCGVCveACPTEAIAIVLEDD--VLRPVVDEDKCVGCGLCEYVCPVeppKAI 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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