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Conserved domains on  [gi|446858784|ref|WP_000936040|]
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glutathione ABC transporter permease GsiC [Escherichia coli]

Protein Classification

glutathione ABC transporter permease GsiC( domain architecture ID 11487626)

glutathione ABC transporter permease GsiC is the transmembrane component of the ABC transporter complex GsiABCD that is involved in glutathione import, and is probably responsible for the translocation of the substrate across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15081 PRK15081
glutathione ABC transporter permease GsiC; Provisional
 1-306 0e+00

glutathione ABC transporter permease GsiC; Provisional


:

Pssm-ID: 185039 [Multi-domain]  Cd Length: 306  Bit Score: 602.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLS 80
Cdd:PRK15081   1 MLNYVIKRLLGLIPTLLIVAVLVFLFVHLLPGDPARLAAGPEADAQVVALVRQQLGLDQPLPHQFWHYISNALQGDFGTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  81 MVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELG 160
Cdd:PRK15081  81 MVSRRPVSEEIASRFMPTLWLTITSMVWAVIFGMAIGIASAVWRNRWPDRLGMTLAVSGISFPAFALGMLLMQVFSVELG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 161 WLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFG 240
Cdd:PRK15081 161 WLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVEVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFG 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446858784 241 FLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK 306
Cdd:PRK15081 241 FLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEVLLFSLEFILINLVVDVLYAAINPAIRYK 306
 
Name Accession Description Interval E-value
PRK15081 PRK15081
glutathione ABC transporter permease GsiC; Provisional
 1-306 0e+00

glutathione ABC transporter permease GsiC; Provisional


Pssm-ID: 185039 [Multi-domain]  Cd Length: 306  Bit Score: 602.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLS 80
Cdd:PRK15081   1 MLNYVIKRLLGLIPTLLIVAVLVFLFVHLLPGDPARLAAGPEADAQVVALVRQQLGLDQPLPHQFWHYISNALQGDFGTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  81 MVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELG 160
Cdd:PRK15081  81 MVSRRPVSEEIASRFMPTLWLTITSMVWAVIFGMAIGIASAVWRNRWPDRLGMTLAVSGISFPAFALGMLLMQVFSVELG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 161 WLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFG 240
Cdd:PRK15081 161 WLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVEVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFG 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446858784 241 FLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK 306
Cdd:PRK15081 241 FLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEVLLFSLEFILINLVVDVLYAAINPAIRYK 306
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-305 7.61e-148

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 417.55  E-value: 7.61e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLS 80
Cdd:COG0601    1 MLRYILRRLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  81 MVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELG 160
Cdd:COG0601   81 FVYGRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 161 WLPTVGA--------DSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVV 232
Cdd:COG0601  161 WLPVSGRvspwedflDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPVV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446858784 233 TMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRY 305
Cdd:COG0601  241 TVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRL 313
nickel_nikB TIGR02789
nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of ...
 1-306 5.32e-89

nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikC. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131836 [Multi-domain]  Cd Length: 314  Bit Score: 268.17  E-value: 5.32e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784    1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPA----RLIAGPEADaQVIELVRQQLGLDQPLYHQFWHYISNAVQGD 76
Cdd:TIGR02789   1 MLNYILRRLLLLIPVVLAASLLAFILIHLGPSDPAedylRLSHIPPTD-EAIADMRHSLGLDQPLYVQYFHWLWNALHLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   77 FGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFS 156
Cdd:TIGR02789  80 FGISYISDRPVLDEIARSLPATLELAGFALVIVVLVSVPLGILAARYRDRLPDHAVRFIIFLGVSIPNFWLAFLLVWGFS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  157 VELGWLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMG 236
Cdd:TIGR02789 160 VYLNLLPTNGAGTWQHLVLPAVTLALMSVSIYARLLRASMLDNMQERYVTYARVRGIKERWVIRRHILRNAILPMITALG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  237 LQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK 306
Cdd:TIGR02789 240 MHIGELLGGTFVIENIFSWPGVGRYAISAIFNRDYPVIQCYTLLMGLLFVFCNLIVDLFQALLDPRIRRK 309
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 113-305 5.75e-31

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 114.70  E-value: 5.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  113 GMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFsvelgwlptvGADSWQHYILPSLTLGAAVAAVMARFT 192
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIA----------ILSILGHGILPAIILALLGWAGYARLI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  193 RASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYP 272
Cdd:pfam00528  71 RRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYP 150

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446858784  273 VIQAEILLFSLEFILINLVVDVLYAAINPAIRY 305
Cdd:pfam00528 151 EIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 95-283 3.93e-21

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 88.49  E-value: 3.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  95 FMPTLWLTITSMVWAVIFGMAAGIIAAvWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELGWlptvgaDSWQHYI 174
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILA-RKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGW------GILPGLG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 175 LPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFN 254
Cdd:cd06261   74 LPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGG 153

                        170       180       190
                 ....*....|....*....|....*....|...
gi 446858784 255 ----WPGLGRLLVDSVEMRDYPVIQAEILLFSL 283
Cdd:cd06261  154 geapGPGTGLLLIFAILFPGDLGVAAAVALILL 186
 
Name Accession Description Interval E-value
PRK15081 PRK15081
glutathione ABC transporter permease GsiC; Provisional
 1-306 0e+00

glutathione ABC transporter permease GsiC; Provisional


Pssm-ID: 185039 [Multi-domain]  Cd Length: 306  Bit Score: 602.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLS 80
Cdd:PRK15081   1 MLNYVIKRLLGLIPTLLIVAVLVFLFVHLLPGDPARLAAGPEADAQVVALVRQQLGLDQPLPHQFWHYISNALQGDFGTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  81 MVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELG 160
Cdd:PRK15081  81 MVSRRPVSEEIASRFMPTLWLTITSMVWAVIFGMAIGIASAVWRNRWPDRLGMTLAVSGISFPAFALGMLLMQVFSVELG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 161 WLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFG 240
Cdd:PRK15081 161 WLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVEVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFG 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446858784 241 FLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK 306
Cdd:PRK15081 241 FLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEVLLFSLEFILINLVVDVLYAAINPAIRYK 306
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 1-305 7.61e-148

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 417.55  E-value: 7.61e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLS 80
Cdd:COG0601    1 MLRYILRRLLQAIPVLLGVSTLVFLLLRLLPGDPAAALLGPRATPEAIAALRAELGLDQPLLVQYLDWLGGLLRGDLGTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  81 MVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELG 160
Cdd:COG0601   81 FVYGRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGSWLDRLITVLALLGISIPSFWLGLLLILLFAVKLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 161 WLPTVGA--------DSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVV 232
Cdd:COG0601  161 WLPVSGRvspwedflDALRHLILPALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPVV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446858784 233 TMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRY 305
Cdd:COG0601  241 TVLGLQLGGLLGGAVVVETVFSWPGLGRLLVDAILNRDYPVVQGIVLLIAVLVVLVNLLVDLLYALLDPRIRL 313
nickel_nikB TIGR02789
nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of ...
 1-306 5.32e-89

nickel ABC transporter, permease subunit NikB; This family consists of the NikB family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikC. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131836 [Multi-domain]  Cd Length: 314  Bit Score: 268.17  E-value: 5.32e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784    1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPA----RLIAGPEADaQVIELVRQQLGLDQPLYHQFWHYISNAVQGD 76
Cdd:TIGR02789   1 MLNYILRRLLLLIPVVLAASLLAFILIHLGPSDPAedylRLSHIPPTD-EAIADMRHSLGLDQPLYVQYFHWLWNALHLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   77 FGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFS 156
Cdd:TIGR02789  80 FGISYISDRPVLDEIARSLPATLELAGFALVIVVLVSVPLGILAARYRDRLPDHAVRFIIFLGVSIPNFWLAFLLVWGFS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  157 VELGWLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMG 236
Cdd:TIGR02789 160 VYLNLLPTNGAGTWQHLVLPAVTLALMSVSIYARLLRASMLDNMQERYVTYARVRGIKERWVIRRHILRNAILPMITALG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  237 LQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK 306
Cdd:TIGR02789 240 MHIGELLGGTFVIENIFSWPGVGRYAISAIFNRDYPVIQCYTLLMGLLFVFCNLIVDLFQALLDPRIRRK 309
PRK10914 PRK10914
dipeptide ABC transporter permease DppB;
1-306 1.96e-88

dipeptide ABC transporter permease DppB;


Pssm-ID: 182834 [Multi-domain]  Cd Length: 339  Bit Score: 267.45  E-value: 1.96e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAG-----PEADAQVIElvrqQLGLDQPLYHQFWHYISNAVQG 75
Cdd:PRK10914   1 MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGergisPERHAQLLA----ELGLDKPMWQQYLHYIWGVMHG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  76 DFGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVF 155
Cdd:PRK10914  77 DLGISLKSRIPVWDEFVPRFKATLELGVCAMIFAVAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 156 SVELGWLPTVG-------------------------------ADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDY 204
Cdd:PRK10914 157 SVHWNLTPVSGrvsdmvflddsnpltgfmlidtaiwgedgnfIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDY 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 205 MRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLE 284
Cdd:PRK10914 237 IRTARAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATM 316

                        330       340
                 ....*....|....*....|..
gi 446858784 285 FILINLVVDVLYAAINPAIRYK 306
Cdd:PRK10914 317 IILVNLLVDLLYGVVNPRIRHK 338
PRK10352 PRK10352
nickel transporter permease NikB; Provisional
 1-304 1.73e-86

nickel transporter permease NikB; Provisional


Pssm-ID: 182400 [Multi-domain]  Cd Length: 314  Bit Score: 261.94  E-value: 1.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPA----RLIAGPEADaQVIELVRQQLGLDQPLYHQFWHYISNAVQGD 76
Cdd:PRK10352   1 MLRYILRRLLLLIPMLLAASVIIFLMLRLGTGDPAldylRLSNLPPTP-EMLASTRTMLGLDQPLYVQYGTWLWKALHLD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  77 FGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFS 156
Cdd:PRK10352  80 FGISFATQRPVLDDLLNFLPATLELAGAALVLILLTSVPLGIWAARHRDRLPDFAVRFIAFLGVSMPNFWLAFLLVMAFS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 157 VELGWLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMG 236
Cdd:PRK10352 160 VYLQWLPAMGYGGWQHIILPAVSIAFMSLAINARLLRASMLEVAGQRHVTWARLRGLSERQVERRHILRNASLPMITAVG 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446858784 237 LQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIR 304
Cdd:PRK10352 240 MHIGELIGGTMIIENIFAWPGVGRYAVSAIFNRDYPVIQCFTLMMVVVFVVCNLIVDLLNAALDPRIR 307
oppB PRK09471
oligopeptide ABC transporter permease OppB;
1-305 1.95e-67

oligopeptide ABC transporter permease OppB;


Pssm-ID: 181886 [Multi-domain]  Cd Length: 306  Bit Score: 212.62  E-value: 1.95e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDParLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLS 80
Cdd:PRK09471   1 MLKFILRRCLEAIPTLFILITISFFMMRLAPGSP--FTGERTLPPEVMANIEAKYHLNDPIMTQYFSYLKQLAHGDFGPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  81 MVSR-RPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVEL 159
Cdd:PRK09471  79 FKYKdYSVNDLVASSFPVSAKLGAAAFFLAVILGVSAGVIAALKQNTKWDYTVMGFAMTGVVIPSFVVAPLLVLIFAITL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 160 GWLPTVG--ADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGL 237
Cdd:PRK09471 159 HWLPGGGwnGGALKFMILPMVALSLAYIASIARITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALKPALLPVLSYMGP 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446858784 238 QFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRY 305
Cdd:PRK09471 239 AFVGIITGSMVIETIFGLPGIGQLFVNGALNRDYSLVLSLTILVGALTILFNAIVDVLYAVIDPKIRY 306
PRK15110 PRK15110
peptide ABC transporter permease SapB;
1-301 8.30e-49

peptide ABC transporter permease SapB;


Pssm-ID: 185065 [Multi-domain]  Cd Length: 321  Bit Score: 165.25  E-value: 8.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEAdaqvielvrqqlgldqplyhqFWHYISNAVQGDFGLS 80
Cdd:PRK15110   1 MIIFTLRRLLLLIVTLFLLTLVGFSLSYFTPHAPLQGASLWDA---------------------WVFWFNGLLHWDFGVS 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  81 MVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELG 160
Cdd:PRK15110  60 SINGQPISEQLKEVFPATMELCILAFGFALLVGIPVGIIAGVTRHKWQDNLISALALLGFSIPVFWLALLLTLFFSLTLG 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 161 WLPTVG----------------ADSW---------------QHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTAR 209
Cdd:PRK15110 140 WLPVSGrfdllyevkpvtgfalIDAWlsdspwrdemimsaiRHMILPVITLAVAPTTEVIRLMRISTIEVYDQNYVKAAA 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 210 AKGVSETRVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILIN 289
Cdd:PRK15110 220 TRGLSRFTILRRHVLHNALPPVIPRLGLQFSTMLTLAMITEMVFSWPGLGRWLINAIRQQDYAAISAGVMVVGSLVIIVN 299

                        330
                 ....*....|..
gi 446858784 290 LVVDVLYAAINP 301
Cdd:PRK15110 300 VLSDILGAMANP 311
YejB COG4174
ABC-type microcin C transport system, permease component YejB [Secondary metabolites ...
 1-305 3.71e-43

ABC-type microcin C transport system, permease component YejB [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443333 [Multi-domain]  Cd Length: 363  Bit Score: 151.49  E-value: 3.71e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDP-----ARL----------IAGPEA--------------------DA 45
Cdd:COG4174    1 MGAYILRRLLLMIPTLLGIMLINFVIVQFAPGGPveqviAQLqgtgggatgrISGGGGdagggaaagggskyrgarglDP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  46 QVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLSMVSRRPVADEIASRfMPT-----LWLT-ITSMVwavifGMAAGII 119
Cdd:COG4174   81 EFIAELEKQYGFDKPAHERFLLMLKNYLRFDFGESYFRDISVIDLILEK-LPVsislgLWSTlLTYLI-----SIPLGIR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 120 AAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFS------------------VELGWLPTVGADSWqHYILPSLTLG 181
Cdd:COG4174  155 KAVRDGSRFDVWTSTVIIVGYAIPGFLFAILLIVLFAggsyfdwfplrgltsdnwDQLSWWGKILDYLW-HLTLPVTAMV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 182 AAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQF-GFLLGGSIVVEKVFNWPGLGR 260
Cdd:COG4174  234 IGGFATLTLLTKNSFLDEIRKQYVLTARAKGLSERRVLYGHVFRNAMLIVIAGFPAAFiGAFFTGSLLIETIFSLDGLGL 313

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 446858784 261 LLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRY 305
Cdd:COG4174  314 LGFEAVVNRDYPVVFGTLYIFTLIGLVLKLISDLTYVLVDPRIDF 358
PRK15133 PRK15133
microcin C ABC transporter permease YejB; Provisional
 1-306 3.80e-32

microcin C ABC transporter permease YejB; Provisional


Pssm-ID: 185087 [Multi-domain]  Cd Length: 364  Bit Score: 122.16  E-value: 3.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784   1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDP----------------------------ARLIAGPEADAQ------ 46
Cdd:PRK15133   1 MGAYLIRRLLLVIPTLWAIITINFFIVQIAPGGPvdqaiaaiefgqagglpgaggegvrashAQTGVGNISDSNyrggrg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  47 ----VIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAV 122
Cdd:PRK15133  81 ldpeVIAEITHRYGFDKPLHERYFKMLWDYIRFDFGDSLFRSASVLTLIKDSLPVSITLGLWSTLIIYLVSIPLGIRKAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 123 WRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFS--VELGWLPTVGADSWQ---------------HYILPSLTLGAAVA 185
Cdd:PRK15133 161 RNGSRFDVWSSAFIIIGYAIPAFLFAILLIVFFAggSYFDLFPLRGLVSANfdslpwyqkitdylwHITLPVLATVIGGF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 186 AVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQF-GFLLGGSIVVEKVFNWPGLGRLLVD 264
Cdd:PRK15133 241 AALTMLTKNSFLDEIRKQYVVTARAKGVSEKNILWKHVFRNAMLLVIAGFPATFiSMFFTGSLLIEVMFSLNGLGLLGYE 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446858784 265 SVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK 306
Cdd:PRK15133 321 ATVSRDYPVMFGTLYIFTLIGLLLNIVSDISYTLVDPRIDFE 362
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 113-305 5.75e-31

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 114.70  E-value: 5.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  113 GMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFsvelgwlptvGADSWQHYILPSLTLGAAVAAVMARFT 192
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIA----------ILSILGHGILPAIILALLGWAGYARLI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  193 RASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYP 272
Cdd:pfam00528  71 RRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYP 150

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446858784  273 VIQAEILLFSLEFILINLVVDVLYAAINPAIRY 305
Cdd:pfam00528 151 EIQGPVLAAALILLLLNLLVDILQRLLDPRVRK 183
BPD_transp_1_N pfam19300
Binding-prot-dependent transport system membrane comp, N-term; This is the N-terminal ...
 1-102 1.66e-21

Binding-prot-dependent transport system membrane comp, N-term; This is the N-terminal transmembrane domain of the Binding-protein-dependent transport system inner membrane component.


Pssm-ID: 437132 [Multi-domain]  Cd Length: 114  Bit Score: 87.28  E-value: 1.66e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784    1 MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGD---- 76
Cdd:pfam19300   1 MLRFLVRRTLGAVVILLIISAVTFFLFYAIPRDPARLACGKNCTPETLALIRHNLGLDKPIPVQYWHFLSGIFAGRdfga 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446858784   77 --------FGLSMVSRRPVADEIASRFMPTLWLT 102
Cdd:pfam19300  81 vghcpapcLGYSFANNEPVWDTIMDRFPTTLSLA 114
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 95-283 3.93e-21

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 88.49  E-value: 3.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  95 FMPTLWLTITSMVWAVIFGMAAGIIAAvWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELGWlptvgaDSWQHYI 174
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILA-RKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGW------GILPGLG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 175 LPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFN 254
Cdd:cd06261   74 LPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGG 153

                        170       180       190
                 ....*....|....*....|....*....|...
gi 446858784 255 ----WPGLGRLLVDSVEMRDYPVIQAEILLFSL 283
Cdd:cd06261  154 geapGPGTGLLLIFAILFPGDLGVAAAVALILL 186
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 98-241 4.47e-11

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 4.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  98 TLWLTITSMVWAVIFGMAAGIIAAVWRnRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELGWLptvgadswqhyilpS 177
Cdd:COG1173   81 SLLVGLLAVLIALVIGVLLGLLAGYFG-GWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNV--------------I 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446858784 178 LTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMGLQFGF 241
Cdd:COG1173  146 LALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIAS 209
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 99-259 6.72e-05

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784  99 LWLTITSMVWAVIFGMAAGIIAA---VWRNRWPD------RLSMTIAVSGISFPAFALGMLLIQVFsvelGWLPTVGAds 169
Cdd:PRK15021 148 LMLTLCSSVMGVLAGALQGYYGGkvdLWGQRFIEvwsgmpTLFLIILLSSVVQPNFWWLLAITVLF----GWMSLVGV-- 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446858784 170 wqhyilpsltlgaavaavmarfTRASFVDVLSEDYMRTARAKGVSETRVVLKHGLRNAMIPVVTMMglqfGFLLGGSIVV 249
Cdd:PRK15021 222 ----------------------VRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFL----PFILCSSITT 275

                        170
                 ....*....|
gi 446858784 250 EKVFNWPGLG 259
Cdd:PRK15021 276 LTSLDFLGFG 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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