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MULTISPECIES: anaerobic ribonucleoside triphosphate reductase [Bacillus]
Protein Classification
anaerobic ribonucleoside-triphosphate reductase ( domain architecture ID 11487400 )
anaerobic ribonucleoside-triphosphate reductase, a class III ribonucleotide reductase, uses an oxygen-sensitive glycyl radical and an iron-sulfur cluster to catalyze the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides during anaerobic conditions
List of domain hits
Name
Accession
Description
Interval
E-value
PRK14704
PRK14704 anaerobic ribonucleoside triphosphate reductase; Provisional
1-619
0e+00
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain]
Cd Length: 618
Bit Score: 1285.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 1 MLQ N NTRGEE e LM K VFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDF 80
Cdd:PRK14704 1 MLQ K NTRGEE - LM R VFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDF 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 81 YATGTTTCSQIPLAQMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFD I DLAPYVRKT I ERHKKRL 160
Cdd:PRK14704 80 YATGTTTCSQIPLAQMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFD V DLAPYVRKT V ERHKKRL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 161 QSYPLTKEQIEEF S WKETENDTYQACEAF V HNSNSMHSRGGGQVPFISINYGTDTSKEGR M LIKQLLKATQAGLGKGETP 240
Cdd:PRK14704 160 QSYPLTKEQIEEF A WKETENDTYQACEAF I HNSNSMHSRGGGQVPFISINYGTDTSKEGR L LIKQLLKATQAGLGKGETP 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 241 IFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPESEVCYMGCRTRVMSNIHGEETAI 320
Cdd:PRK14704 240 IFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPESEVCYMGCRTRVMSNIHGEETAI 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 321 GRGNLSFTSINLVKLALISGSKEAFFEALNYYLDLGIKQLLERF A YQCTKRARDF Q FLYSQGVWRGGE T L H PEDSVASIL 400
Cdd:PRK14704 320 GRGNLSFTSINLVKLALISGSKEAFFEALNYYLDLGIKQLLERF E YQCTKRARDF R FLYSQGVWRGGE K L Q PEDSVASIL 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 401 KQGTLS I GFIGLAECLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEH Q LNFSVIATPAEGLSGKFVKKDR K EFGV 480
Cdd:PRK14704 400 KQGTLS L GFIGLAECLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEH E LNFSVIATPAEGLSGKFVKKDR E EFGV 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 481 ISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDGAAMHNKKALKQIVQAMAEHGVGYGSINHPV 560
Cdd:PRK14704 480 ISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDGAAMHNKKALKQIVQAMAEHGVGYGSINHPV 559
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 446862820 561 DRCKCCSYHGVIGNECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE I DRVKHK 619
Cdd:PRK14704 560 DRCKCCSYHGVIGNECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE M DRVKHK 618
Name
Accession
Description
Interval
E-value
PRK14704
PRK14704 anaerobic ribonucleoside triphosphate reductase; Provisional
1-619
0e+00
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain]
Cd Length: 618
Bit Score: 1285.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 1 MLQ N NTRGEE e LM K VFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDF 80
Cdd:PRK14704 1 MLQ K NTRGEE - LM R VFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDF 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 81 YATGTTTCSQIPLAQMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFD I DLAPYVRKT I ERHKKRL 160
Cdd:PRK14704 80 YATGTTTCSQIPLAQMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFD V DLAPYVRKT V ERHKKRL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 161 QSYPLTKEQIEEF S WKETENDTYQACEAF V HNSNSMHSRGGGQVPFISINYGTDTSKEGR M LIKQLLKATQAGLGKGETP 240
Cdd:PRK14704 160 QSYPLTKEQIEEF A WKETENDTYQACEAF I HNSNSMHSRGGGQVPFISINYGTDTSKEGR L LIKQLLKATQAGLGKGETP 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 241 IFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPESEVCYMGCRTRVMSNIHGEETAI 320
Cdd:PRK14704 240 IFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPESEVCYMGCRTRVMSNIHGEETAI 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 321 GRGNLSFTSINLVKLALISGSKEAFFEALNYYLDLGIKQLLERF A YQCTKRARDF Q FLYSQGVWRGGE T L H PEDSVASIL 400
Cdd:PRK14704 320 GRGNLSFTSINLVKLALISGSKEAFFEALNYYLDLGIKQLLERF E YQCTKRARDF R FLYSQGVWRGGE K L Q PEDSVASIL 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 401 KQGTLS I GFIGLAECLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEH Q LNFSVIATPAEGLSGKFVKKDR K EFGV 480
Cdd:PRK14704 400 KQGTLS L GFIGLAECLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEH E LNFSVIATPAEGLSGKFVKKDR E EFGV 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 481 ISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDGAAMHNKKALKQIVQAMAEHGVGYGSINHPV 560
Cdd:PRK14704 480 ISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDGAAMHNKKALKQIVQAMAEHGVGYGSINHPV 559
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 446862820 561 DRCKCCSYHGVIGNECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE I DRVKHK 619
Cdd:PRK14704 560 DRCKCCSYHGVIGNECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE M DRVKHK 618
NrdD
TIGR02487 anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ...
29-618
0e+00
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain]
Cd Length: 579
Bit Score: 789.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 29 Q ENAN V D GRS P MGVMGTF ASE SA K Y YA VEN LL SDQVKK A INENILYP HDLD FYA T G TT T C SQIP L AQM L AN GF H TG HGHM 108
Cdd:TIGR02487 1 N ENAN M D SPT P STQRKLI ASE VS K D YA LLH LL PKDIAR A HLNGDIHI HDLD YAL T L TT N C CLHD L RNL L KY GF R TG NIVS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 109 RQ P QD I KS AL ALSSI I F Q AN QN M Q H GGQSF AL FD ID LAPY VR KT IER H K K R LQ SYP L TKEQIE E FSWKE T EN D TY QA CEA 188
Cdd:TIGR02487 81 KP P KH I DV AL NHIVN I L Q SL QN E Q Y GGQSF PE FD TL LAPY IE KT NLK H R K V LQ QLQ L LLFEAT E YAARR T FT D VT QA MQG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 189 FVH N S N SM HS R GG g Q V PF I SI N YGT D TSKEGRM LI K Q LL KATQA G L GKGE TP IFP IQ IFK MKK G V N FE E S DP n YDLFELA 268
Cdd:TIGR02487 161 PEY N P N TL HS A GG - Q T PF E SI G YGT E TSKEGRM IA K A LL DVRME G D GKGE PF IFP KI IFK VRE G F N WD E P DP - YDLFELA 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 269 L E TT A E R LF P N F SF LD APF N a V HY D G R pesev CY MGCRT RVMS N IH -- GEE TA IGRGN LSF TSINL VKL A LI S - G SK E A F 345
Cdd:TIGR02487 239 F E CA A K R GY P Y F LN LD PED N - V KE D V R ----- YP MGCRT FLSP N EN gd GEE SY IGRGN IGV TSINL PRI A YK S r G DE E E F 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 346 FE A L NY YL DLGIKQ L LE R FA Y QCTKR A R D FQFL YSQG V W R GG ET L hp ED SV AS ILK Q GT L SIGFIGL A E C LVALTGKH HG 425
Cdd:TIGR02487 313 FE E L DE YL EIAKEA L EI R RE Y LKKML A K D LPPM YSQG G W D GG NL L -- DE SV EE ILK S GT N SIGFIGL N E A LVALTGKH LH 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 426 E D EE SWK L GYE I IS F M RD RM D KATE E HQ LN F SV I ATPAE G L S G K F V KKDR K EFG V I S G I T NHN YYTNSFH I PVY YNIQAI 505
Cdd:TIGR02487 391 E E EE ARE L AIR I LE F I RD KA D EFKK E TG LN Y SV Y ATPAE S L C G R F A KKDR E EFG E I P G V T DKP YYTNSFH V PVY EDVNLG 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 506 N KI RL E G PFH A L C NGGHITYIELD G A AMHN k K ALK Q I VQAMAEH G V GY GS IN H PVD R C KC C S Y H G VIG N - E CP S CG NE D e 584
Cdd:TIGR02487 471 E KI DI E A PFH P L T NGGHITYIELD E A IPDP - E ALK D I TKKAMKN G I GY FG IN P PVD V C ED C G Y T G EGL N d K CP K CG SH D - 548
570 580 590
....*....|....*....|....*....|....
gi 446862820 585 an IE R I R RITGYL v G DMSK WN SA K RS E EI DR V KH 618
Cdd:TIGR02487 549 -- IE V I S RITGYL - G PVEN WN DG K QA E FK DR K KH 579
NRDD
pfam13597 Anaerobic ribonucleoside-triphosphate reductase;
31-618
0e+00
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain]
Cd Length: 554
Bit Score: 757.80
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 31 NAN V D GR SP M G VMGTF A S E SA K Y YA VEN LL SDQVKK A IN E NILYP HDLD F YA TG T TT C SQ I P L AQM L A NGF H TG H G HM R Q 110
Cdd:pfam13597 1 NAN K D SY SP S G QRLYI A G E VS K D YA LRK LL PPEIAD A HE E GDIHI HDLD Y YA LR T PY C CG I D L RDL L E NGF V TG N G VS R P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 111 P QD I KS A L A LSSI I FQAN QN M Q H GGQ S F AL FD ID LAP Y VRK TI E R H K K R L qsypltkeqieefswke T ENDTY QA CE AFV 190
Cdd:pfam13597 81 P KH I ET A C A QAVN I LATV QN E Q A GGQ A F SS FD TY LAP F VRK DY E K H L K G L ----------------- T YKEVK QA MQ AFV 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 191 H N S N S M H SR G GGQ V PF IS IN Y G T DT S KEGR ---- M L IK Q LL KATQA G L G K G E TP I - FPI Q I F K M K K G V N FE E S DPNYDLF 265
Cdd:pfam13597 144 Y N L N T M P SR R GGQ T PF TN IN L G L DT P KEGR demd M I IK A LL EVMLE G D G N G G TP F t FPI P I Y K L K E G F N WD E G DPNYDLF 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 266 ELA L E T TA E R LF P N FS FL D apfnavh Y D GR P ESE - V CY MGCR T R VMSNIHGEETAIG RGN LSFTS INL VKL A LIS - G SKE 343
Cdd:pfam13597 224 ELA F E C TA K R GY P Y FS NF D ------- S D LL P GDG y V AS MGCR L R LDLRPNRKRFGGL RGN IGVVT INL PRI A YEA a G DED 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 344 A FFE A L NYY L D L GIKQ LL E R FAYQCTKR A RD - FQ FL YSQ G VW RGG ET lhpedsvasilkqg TL S IGFIGL A E C L V ALTGK 422
Cdd:pfam13597 297 K FFE L L DER L E L AKEA LL I R REVLKKLL A KG l LP FL MGE G YL RGG NH -------------- TL T IGFIGL N E A L K ALTGK 362
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 423 HHGE D EE SWKLGYE I ISF MR DRM D KAT EE HQ LNFS VI ATPAE G LS GK F V K K D R K E FG V I S G I T NHN YYTNSFH I PV Y Y N I 502
Cdd:pfam13597 363 HHGE S EE AKEFALK I LKH MR EKA D EWK EE TG LNFS LE ATPAE S LS YR F A K L D K K R FG E I K G V T DKP YYTNSFH V PV D Y T I 442
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 503 Q A IN K IR LE G PF HA L CN GGHI TYI EL D g A A MH N KK AL KQI V QAMAEH G V GY G SIN H P V D R C KC C S Y H G V I G n ECP S CGN E 582
Cdd:pfam13597 443 D A FE K LK LE A PF QP L TT GGHI SHV EL G - E A QP N PE AL EKL V RIAYDT G I GY F SIN P P I D V C PD C G Y T G E I E - ECP N CGN H 520
570 580 590
....*....|....*....|....*....|....*.
gi 446862820 583 DE a NI E R IRRITGYL VGDMS k WN SA K RS E EI DRVKH 618
Cdd:pfam13597 521 DE - KV E V IRRITGYL RPVSD - WN KG K QA E LK DRVKH 554
NrdD
COG1328 Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ...
10-608
0e+00
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain]
Cd Length: 671
Bit Score: 690.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 10 EE L MKVF E TIVHGNE q DLMQ ENAN V d GR S PMGVMGTF A S E SA K Y YA VENL L SDQ V KK A INENILYP HDLD FYAT g T T T C S 89
Cdd:COG1328 101 TT L VDDI E LLDEYDD - WRVN ENAN K - SY S FSTQRDLI A G E VS K E YA LNKI L PPE V AD A HRNGDIHI HDLD YLPR - M T N C C 177
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 90 QIP L AQM L A NGF HT G H G HMRQ P QD I KS ALA LSSI I FQAN Q NM Q H GGQ S F AL FD ID LAPYVRK tierhkkrlqsypltkeq 169
Cdd:COG1328 178 LWD L RDL L K NGF NG G N G KVEP P KH I QT ALA QMAQ I IATV Q SE Q A GGQ A F SR FD TY LAPYVRK ------------------ 239
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 170 ie EFSWKE T ENDTY QA CEAFVH N S N SMH SR G G g Q V PF I SI NY G TD T ---- S K E G RM LI K QL L KATQA G L G K G E T P IFP IQ 245
Cdd:COG1328 240 -- DKLEGK T YKEIK QA MQSLEY N L N TLP SR R G - Q T PF T SI TF G LG T pedf S W E M RM IN K AI L EVRIE G D G E G R T F IFP KL 316
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 246 IF KMKK G V N F E ES DPNYDL FE LA L E T TA E R LF P N F SFL D APFN av H Y D G rpe S EVCY MGCR TRVMSNIH GEE TAI GRGNL 325
Cdd:COG1328 317 IF NITE G F N W E PE DPNYDL LQ LA F E C TA K R GY P Y F LNY D NSDE -- L Y K G --- S FKRS MGCR LFLDGWEN GEE LNR GRGNL 391
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 326 SFTSI NL VKL A LIS - G SK E A FFE A L NYY LDL GIKQ L LERFAY - Q CTKR A RDFQF LY SQ G VW rg GET L H P E DS VASIL K Q G 403
Cdd:COG1328 392 GVVTL NL PRI A YEA k G DE E K FFE I L DER LDL AKEA L EIKRKR l Q KLAK A GLAPI LY QT G AY -- LGR L K P D DS IDELF K N G 469
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 404 TLS IG F IGL A E C L VAL TGKHH G E D EE SWKLGY EI ISF MR D R M D KAT EE HQLNF S VI ATPAE G L SGK F V K K D R K E FG V I S G 483
Cdd:COG1328 470 FST IG Y IGL N E M L LNF TGKHH I E S EE AKAFAL EI LKH MR E R A D EWQ EE TGYLY S LY ATPAE S L TYR F A K L D K K R FG D I I G 549
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 484 I T NHN YYTNSFH I PV YYN I QAIN K IRL E GPFHA L CN GG H I T Y I EL d G AAMH N KK AL KQI V Q - A MAEHGV GY GS IN H P V D R 562
Cdd:COG1328 550 V T DKP YYTNSFH L PV RKT I DPFE K LDF E DEYQP L YT GG T I S Y V EL - G ELQP N PE AL EAV V R y A YDNYRI GY LG IN P P F D I 628
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 446862820 563 C KC C S Y H G VIGN ECP S CGNED ea NI E R IRR IT GYL VGD m SK WN SA K 608
Cdd:COG1328 629 C PK C G Y L G GEHD ECP K CGNED -- TV E V IRR TC GYL GNV - QP WN DG K 671
RNR_III
cd01675 Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
30-599
0e+00
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain]
Cd Length: 555
Bit Score: 644.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 30 ENANVD G r SP MGV M GTF A SESA K Y Y AVENL L SDQVKK A INENILYP HDLD FYAT g T TT C SQIP L AQM L AN GF H TG H G HMR 109
Cdd:cd01675 1 ENANVD S - SP GST M KDL A AGIV K K Y YLLKI L PKEIAR A HLNGDIHI HDLD YLPL - T PY C CGWD L RPL L EK GF T TG N G IIE 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 110 Q P QDIK SAL ALSSIIFQAN QN M Q H GGQ S F AL FD ID LAP Y VRK TIERHKKRL qsypltkeqieefswke T ENDTY QA CEA F 189
Cdd:cd01675 79 P P KHLS SAL GHIVNFLGTV QN E Q A GGQ A F PE FD TY LAP F VRK DYLKYRLTA ----------------- T RKEIK QA MQG F 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 190 VH N S N S m H SR G GGQ V PF IS I NY G ------------------- T DT S KE G RM LI K QL L KATQA G LG KG ETPI FPI QI F KMK 250
Cdd:cd01675 142 IY N L N T - L SR R GGQ T PF TN I TL G lvcpkdlefegggepvfty G DT D KE A RM IQ K AF L EVRLE G DA KG RPFT FPI PT F NVT 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 251 K G V N F ees DPNYDL F ELA L E TT A E R LF P N F SFL D APF N AVHY dgrpese V CY MGCR TRVMS N IH ----- G E ETAI G R GN L 325
Cdd:cd01675 221 E G F N L --- DPNYDL K ELA F E CA A K R GY P Y F LNF D NSD N VPGD ------- V RA MGCR LFLDK N EL krggg L E GSGD G T GN I 290
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 326 SFTS INL VKL A LIS - G SK E A FFE A L NY YL D L GIKQ L LE R FAYQCTKR AR DFQF LY SQ G VWR G GE tlhpedsv AS ILK QG T 404
Cdd:cd01675 291 GVVT INL PRI A YEA r G DE E K FFE L L DE YL E L AKDA L EI R RKRLKEAL AR GLPP LY QE G LGG G KL -------- LF ILK RH T 362
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 405 L S IGFIGL A E CLV ALTGK HH GE D EE SWKL G YE I ISFM R D R M D KAT EE HQ L NF SV I ATPAE G L SGK F V KKDRK EF G - V I S G 483
Cdd:cd01675 363 L T IGFIGL N E AAE ALTGK GI GE S EE AREF G IR I LEHI R E R A D EFK EE TG L LY SV E ATPAE S L AYR F A KKDRK KY G d I I P G 442
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 484 I T NHN YYTNSFH I PVY YN I QAIN KI RL E GPF H A L CN GGHI TY IEL DG a A MH N KK AL KQI V QAM A EH GV G Y GS IN H P V D R C 563
Cdd:cd01675 443 V T DKP YYTNSFH V PVY ED I DPFE KI DI E AKL H P L TT GGHI LH IEL GE - A KP N PE AL EAL V KKA A KR GV I Y FG IN T P I D I C 521
570 580 590
....*....|....*....|....*....|....*..
gi 446862820 564 KC C S Y H G - VI G NE CP S CG N ED ean I E R I R RITGYL VG 599
Cdd:cd01675 522 ND C G Y I G e GE G FK CP K CG S ED --- V E V I S RITGYL GP 555
Name
Accession
Description
Interval
E-value
PRK14704
PRK14704 anaerobic ribonucleoside triphosphate reductase; Provisional
1-619
0e+00
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain]
Cd Length: 618
Bit Score: 1285.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 1 MLQ N NTRGEE e LM K VFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDF 80
Cdd:PRK14704 1 MLQ K NTRGEE - LM R VFETIVHGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDF 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 81 YATGTTTCSQIPLAQMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFD I DLAPYVRKT I ERHKKRL 160
Cdd:PRK14704 80 YATGTTTCSQIPLAQMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFD V DLAPYVRKT V ERHKKRL 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 161 QSYPLTKEQIEEF S WKETENDTYQACEAF V HNSNSMHSRGGGQVPFISINYGTDTSKEGR M LIKQLLKATQAGLGKGETP 240
Cdd:PRK14704 160 QSYPLTKEQIEEF A WKETENDTYQACEAF I HNSNSMHSRGGGQVPFISINYGTDTSKEGR L LIKQLLKATQAGLGKGETP 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 241 IFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPESEVCYMGCRTRVMSNIHGEETAI 320
Cdd:PRK14704 240 IFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPESEVCYMGCRTRVMSNIHGEETAI 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 321 GRGNLSFTSINLVKLALISGSKEAFFEALNYYLDLGIKQLLERF A YQCTKRARDF Q FLYSQGVWRGGE T L H PEDSVASIL 400
Cdd:PRK14704 320 GRGNLSFTSINLVKLALISGSKEAFFEALNYYLDLGIKQLLERF E YQCTKRARDF R FLYSQGVWRGGE K L Q PEDSVASIL 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 401 KQGTLS I GFIGLAECLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEH Q LNFSVIATPAEGLSGKFVKKDR K EFGV 480
Cdd:PRK14704 400 KQGTLS L GFIGLAECLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEH E LNFSVIATPAEGLSGKFVKKDR E EFGV 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 481 ISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDGAAMHNKKALKQIVQAMAEHGVGYGSINHPV 560
Cdd:PRK14704 480 ISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDGAAMHNKKALKQIVQAMAEHGVGYGSINHPV 559
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 446862820 561 DRCKCCSYHGVIGNECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE I DRVKHK 619
Cdd:PRK14704 560 DRCKCCSYHGVIGNECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE M DRVKHK 618
PRK07111
PRK07111 anaerobic ribonucleoside triphosphate reductase; Provisional
11-618
0e+00
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain]
Cd Length: 735
Bit Score: 960.94
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 11 E LMK VF E T I vh GN EQ D L mq ENANV D G RS P M G V M GTF ASES A K Y Y AVEN LL SDQVK KA INENILYP HDLDFY AT g TTTC S Q 90
Cdd:PRK07111 100 D LMK AI E E I -- GN DT D R -- ENANV S G NT P S G K M LRI ASES N K D Y YNLY LL PKELA KA HENGDIHI HDLDFY NL - TTTC L Q 174
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 91 I P L AQM L AN GF H TGHG HM R Q P QD I K SA L AL SS II F Q A NQN MQ HGGQS FAL FD I D L AP Y V R KT IE RH K K RLQSYP L ----- 165
Cdd:PRK07111 175 I D L KKL L ER GF N TGHG YI R E P KR I E SA A AL AC II L Q S NQN DM HGGQS IPN FD N D M AP F V E KT FR RH R K EILEKL L elgvg 254
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 166 ----------------------------- TK E QIE E FSW KET END TYQA C E A F V HN S N S MHSR G G G QVPF I SINYGTDTS 216
Cdd:PRK07111 255 eevdekeslneeeellllllaldfniakk AQ E KAD E LAE KET RKR TYQA M E G F I HN L N T MHSR A G A QVPF S SINYGTDTS 334
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 217 K EGRM LIKQ LL K AT QA GLGKGETPIFPIQIF KM K K GVN FE E S DPNYDLF E LA LETT A E RLFPNFSFLDAPFN AVH YD - GR 295
Cdd:PRK07111 335 P EGRM VCEN LL L AT EK GLGKGETPIFPIQIF RV K E GVN YN E E DPNYDLF K LA CRVA A K RLFPNFSFLDAPFN KEY YD k GR 414
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 296 P ES EV CY MGCRTRVMSN IH GEE TAI GRGNLSFT S INL VK LA LIS - GSKEA FFE A L NYY L D L G I K QLL E R FAY Q C T KRAR D 374
Cdd:PRK07111 415 P PT EV AT MGCRTRVMSN VN GEE GTK GRGNLSFT T INL PR LA IEA k KDIDK FFE L L DER L E L A I E QLL H R YEV Q K T LKVK D 494
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 375 F Q FL YS QG V W R G G E T L H P E DS VASI LKQGTL S IGFIGLAE C LVALTGKHHGE D EE SWK LG YE I I S F MRD RM D KAT EE HQ L 454
Cdd:PRK07111 495 F P FL MG QG L W K G S E N L G P D DS IEPV LKQGTL G IGFIGLAE T LVALTGKHHGE S EE AQE LG LK I V S H MRD FC D EYK EE YK L 574
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 455 N F S VI ATPAEGLSG K F V K K DRK E FG V I S G I T NHN YYTNSFH I PVYY N I QAIN KI RL E G P F H A L C NGGHI T Y I ELDG AAMH 534
Cdd:PRK07111 575 N Y S LL ATPAEGLSG R F I K M DRK K FG E I K G V T DKE YYTNSFH V PVYY P I SIFE KI EI E A P Y H K L T NGGHI S Y V ELDG DPSK 654
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 535 N KK A LKQ IV Q AM AEHGV GYGSINHPVDRC KC C S Y H GVI GNE CP S CG NE dea NI E RIRRITGYL v G DMSKW NSAK RS E EI D 614
Cdd:PRK07111 655 N VE A FEI IV K AM KNTNI GYGSINHPVDRC PV C G Y L GVI EDK CP K CG ST --- NI Q RIRRITGYL - G TLDRF NSAK KA E RR D 730
....
gi 446862820 615 RVKH 618
Cdd:PRK07111 731 RVKH 734
NrdD
TIGR02487 anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ...
29-618
0e+00
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain]
Cd Length: 579
Bit Score: 789.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 29 Q ENAN V D GRS P MGVMGTF ASE SA K Y YA VEN LL SDQVKK A INENILYP HDLD FYA T G TT T C SQIP L AQM L AN GF H TG HGHM 108
Cdd:TIGR02487 1 N ENAN M D SPT P STQRKLI ASE VS K D YA LLH LL PKDIAR A HLNGDIHI HDLD YAL T L TT N C CLHD L RNL L KY GF R TG NIVS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 109 RQ P QD I KS AL ALSSI I F Q AN QN M Q H GGQSF AL FD ID LAPY VR KT IER H K K R LQ SYP L TKEQIE E FSWKE T EN D TY QA CEA 188
Cdd:TIGR02487 81 KP P KH I DV AL NHIVN I L Q SL QN E Q Y GGQSF PE FD TL LAPY IE KT NLK H R K V LQ QLQ L LLFEAT E YAARR T FT D VT QA MQG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 189 FVH N S N SM HS R GG g Q V PF I SI N YGT D TSKEGRM LI K Q LL KATQA G L GKGE TP IFP IQ IFK MKK G V N FE E S DP n YDLFELA 268
Cdd:TIGR02487 161 PEY N P N TL HS A GG - Q T PF E SI G YGT E TSKEGRM IA K A LL DVRME G D GKGE PF IFP KI IFK VRE G F N WD E P DP - YDLFELA 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 269 L E TT A E R LF P N F SF LD APF N a V HY D G R pesev CY MGCRT RVMS N IH -- GEE TA IGRGN LSF TSINL VKL A LI S - G SK E A F 345
Cdd:TIGR02487 239 F E CA A K R GY P Y F LN LD PED N - V KE D V R ----- YP MGCRT FLSP N EN gd GEE SY IGRGN IGV TSINL PRI A YK S r G DE E E F 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 346 FE A L NY YL DLGIKQ L LE R FA Y QCTKR A R D FQFL YSQG V W R GG ET L hp ED SV AS ILK Q GT L SIGFIGL A E C LVALTGKH HG 425
Cdd:TIGR02487 313 FE E L DE YL EIAKEA L EI R RE Y LKKML A K D LPPM YSQG G W D GG NL L -- DE SV EE ILK S GT N SIGFIGL N E A LVALTGKH LH 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 426 E D EE SWK L GYE I IS F M RD RM D KATE E HQ LN F SV I ATPAE G L S G K F V KKDR K EFG V I S G I T NHN YYTNSFH I PVY YNIQAI 505
Cdd:TIGR02487 391 E E EE ARE L AIR I LE F I RD KA D EFKK E TG LN Y SV Y ATPAE S L C G R F A KKDR E EFG E I P G V T DKP YYTNSFH V PVY EDVNLG 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 506 N KI RL E G PFH A L C NGGHITYIELD G A AMHN k K ALK Q I VQAMAEH G V GY GS IN H PVD R C KC C S Y H G VIG N - E CP S CG NE D e 584
Cdd:TIGR02487 471 E KI DI E A PFH P L T NGGHITYIELD E A IPDP - E ALK D I TKKAMKN G I GY FG IN P PVD V C ED C G Y T G EGL N d K CP K CG SH D - 548
570 580 590
....*....|....*....|....*....|....
gi 446862820 585 an IE R I R RITGYL v G DMSK WN SA K RS E EI DR V KH 618
Cdd:TIGR02487 549 -- IE V I S RITGYL - G PVEN WN DG K QA E FK DR K KH 579
NRDD
pfam13597 Anaerobic ribonucleoside-triphosphate reductase;
31-618
0e+00
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain]
Cd Length: 554
Bit Score: 757.80
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 31 NAN V D GR SP M G VMGTF A S E SA K Y YA VEN LL SDQVKK A IN E NILYP HDLD F YA TG T TT C SQ I P L AQM L A NGF H TG H G HM R Q 110
Cdd:pfam13597 1 NAN K D SY SP S G QRLYI A G E VS K D YA LRK LL PPEIAD A HE E GDIHI HDLD Y YA LR T PY C CG I D L RDL L E NGF V TG N G VS R P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 111 P QD I KS A L A LSSI I FQAN QN M Q H GGQ S F AL FD ID LAP Y VRK TI E R H K K R L qsypltkeqieefswke T ENDTY QA CE AFV 190
Cdd:pfam13597 81 P KH I ET A C A QAVN I LATV QN E Q A GGQ A F SS FD TY LAP F VRK DY E K H L K G L ----------------- T YKEVK QA MQ AFV 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 191 H N S N S M H SR G GGQ V PF IS IN Y G T DT S KEGR ---- M L IK Q LL KATQA G L G K G E TP I - FPI Q I F K M K K G V N FE E S DPNYDLF 265
Cdd:pfam13597 144 Y N L N T M P SR R GGQ T PF TN IN L G L DT P KEGR demd M I IK A LL EVMLE G D G N G G TP F t FPI P I Y K L K E G F N WD E G DPNYDLF 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 266 ELA L E T TA E R LF P N FS FL D apfnavh Y D GR P ESE - V CY MGCR T R VMSNIHGEETAIG RGN LSFTS INL VKL A LIS - G SKE 343
Cdd:pfam13597 224 ELA F E C TA K R GY P Y FS NF D ------- S D LL P GDG y V AS MGCR L R LDLRPNRKRFGGL RGN IGVVT INL PRI A YEA a G DED 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 344 A FFE A L NYY L D L GIKQ LL E R FAYQCTKR A RD - FQ FL YSQ G VW RGG ET lhpedsvasilkqg TL S IGFIGL A E C L V ALTGK 422
Cdd:pfam13597 297 K FFE L L DER L E L AKEA LL I R REVLKKLL A KG l LP FL MGE G YL RGG NH -------------- TL T IGFIGL N E A L K ALTGK 362
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 423 HHGE D EE SWKLGYE I ISF MR DRM D KAT EE HQ LNFS VI ATPAE G LS GK F V K K D R K E FG V I S G I T NHN YYTNSFH I PV Y Y N I 502
Cdd:pfam13597 363 HHGE S EE AKEFALK I LKH MR EKA D EWK EE TG LNFS LE ATPAE S LS YR F A K L D K K R FG E I K G V T DKP YYTNSFH V PV D Y T I 442
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 503 Q A IN K IR LE G PF HA L CN GGHI TYI EL D g A A MH N KK AL KQI V QAMAEH G V GY G SIN H P V D R C KC C S Y H G V I G n ECP S CGN E 582
Cdd:pfam13597 443 D A FE K LK LE A PF QP L TT GGHI SHV EL G - E A QP N PE AL EKL V RIAYDT G I GY F SIN P P I D V C PD C G Y T G E I E - ECP N CGN H 520
570 580 590
....*....|....*....|....*....|....*.
gi 446862820 583 DE a NI E R IRRITGYL VGDMS k WN SA K RS E EI DRVKH 618
Cdd:pfam13597 521 DE - KV E V IRRITGYL RPVSD - WN KG K QA E LK DRVKH 554
NrdD
COG1328 Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ...
10-608
0e+00
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain]
Cd Length: 671
Bit Score: 690.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 10 EE L MKVF E TIVHGNE q DLMQ ENAN V d GR S PMGVMGTF A S E SA K Y YA VENL L SDQ V KK A INENILYP HDLD FYAT g T T T C S 89
Cdd:COG1328 101 TT L VDDI E LLDEYDD - WRVN ENAN K - SY S FSTQRDLI A G E VS K E YA LNKI L PPE V AD A HRNGDIHI HDLD YLPR - M T N C C 177
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 90 QIP L AQM L A NGF HT G H G HMRQ P QD I KS ALA LSSI I FQAN Q NM Q H GGQ S F AL FD ID LAPYVRK tierhkkrlqsypltkeq 169
Cdd:COG1328 178 LWD L RDL L K NGF NG G N G KVEP P KH I QT ALA QMAQ I IATV Q SE Q A GGQ A F SR FD TY LAPYVRK ------------------ 239
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 170 ie EFSWKE T ENDTY QA CEAFVH N S N SMH SR G G g Q V PF I SI NY G TD T ---- S K E G RM LI K QL L KATQA G L G K G E T P IFP IQ 245
Cdd:COG1328 240 -- DKLEGK T YKEIK QA MQSLEY N L N TLP SR R G - Q T PF T SI TF G LG T pedf S W E M RM IN K AI L EVRIE G D G E G R T F IFP KL 316
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 246 IF KMKK G V N F E ES DPNYDL FE LA L E T TA E R LF P N F SFL D APFN av H Y D G rpe S EVCY MGCR TRVMSNIH GEE TAI GRGNL 325
Cdd:COG1328 317 IF NITE G F N W E PE DPNYDL LQ LA F E C TA K R GY P Y F LNY D NSDE -- L Y K G --- S FKRS MGCR LFLDGWEN GEE LNR GRGNL 391
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 326 SFTSI NL VKL A LIS - G SK E A FFE A L NYY LDL GIKQ L LERFAY - Q CTKR A RDFQF LY SQ G VW rg GET L H P E DS VASIL K Q G 403
Cdd:COG1328 392 GVVTL NL PRI A YEA k G DE E K FFE I L DER LDL AKEA L EIKRKR l Q KLAK A GLAPI LY QT G AY -- LGR L K P D DS IDELF K N G 469
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 404 TLS IG F IGL A E C L VAL TGKHH G E D EE SWKLGY EI ISF MR D R M D KAT EE HQLNF S VI ATPAE G L SGK F V K K D R K E FG V I S G 483
Cdd:COG1328 470 FST IG Y IGL N E M L LNF TGKHH I E S EE AKAFAL EI LKH MR E R A D EWQ EE TGYLY S LY ATPAE S L TYR F A K L D K K R FG D I I G 549
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 484 I T NHN YYTNSFH I PV YYN I QAIN K IRL E GPFHA L CN GG H I T Y I EL d G AAMH N KK AL KQI V Q - A MAEHGV GY GS IN H P V D R 562
Cdd:COG1328 550 V T DKP YYTNSFH L PV RKT I DPFE K LDF E DEYQP L YT GG T I S Y V EL - G ELQP N PE AL EAV V R y A YDNYRI GY LG IN P P F D I 628
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 446862820 563 C KC C S Y H G VIGN ECP S CGNED ea NI E R IRR IT GYL VGD m SK WN SA K 608
Cdd:COG1328 629 C PK C G Y L G GEHD ECP K CGNED -- TV E V IRR TC GYL GNV - QP WN DG K 671
RNR_III
cd01675 Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
30-599
0e+00
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain]
Cd Length: 555
Bit Score: 644.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 30 ENANVD G r SP MGV M GTF A SESA K Y Y AVENL L SDQVKK A INENILYP HDLD FYAT g T TT C SQIP L AQM L AN GF H TG H G HMR 109
Cdd:cd01675 1 ENANVD S - SP GST M KDL A AGIV K K Y YLLKI L PKEIAR A HLNGDIHI HDLD YLPL - T PY C CGWD L RPL L EK GF T TG N G IIE 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 110 Q P QDIK SAL ALSSIIFQAN QN M Q H GGQ S F AL FD ID LAP Y VRK TIERHKKRL qsypltkeqieefswke T ENDTY QA CEA F 189
Cdd:cd01675 79 P P KHLS SAL GHIVNFLGTV QN E Q A GGQ A F PE FD TY LAP F VRK DYLKYRLTA ----------------- T RKEIK QA MQG F 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 190 VH N S N S m H SR G GGQ V PF IS I NY G ------------------- T DT S KE G RM LI K QL L KATQA G LG KG ETPI FPI QI F KMK 250
Cdd:cd01675 142 IY N L N T - L SR R GGQ T PF TN I TL G lvcpkdlefegggepvfty G DT D KE A RM IQ K AF L EVRLE G DA KG RPFT FPI PT F NVT 220
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 251 K G V N F ees DPNYDL F ELA L E TT A E R LF P N F SFL D APF N AVHY dgrpese V CY MGCR TRVMS N IH ----- G E ETAI G R GN L 325
Cdd:cd01675 221 E G F N L --- DPNYDL K ELA F E CA A K R GY P Y F LNF D NSD N VPGD ------- V RA MGCR LFLDK N EL krggg L E GSGD G T GN I 290
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 326 SFTS INL VKL A LIS - G SK E A FFE A L NY YL D L GIKQ L LE R FAYQCTKR AR DFQF LY SQ G VWR G GE tlhpedsv AS ILK QG T 404
Cdd:cd01675 291 GVVT INL PRI A YEA r G DE E K FFE L L DE YL E L AKDA L EI R RKRLKEAL AR GLPP LY QE G LGG G KL -------- LF ILK RH T 362
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 405 L S IGFIGL A E CLV ALTGK HH GE D EE SWKL G YE I ISFM R D R M D KAT EE HQ L NF SV I ATPAE G L SGK F V KKDRK EF G - V I S G 483
Cdd:cd01675 363 L T IGFIGL N E AAE ALTGK GI GE S EE AREF G IR I LEHI R E R A D EFK EE TG L LY SV E ATPAE S L AYR F A KKDRK KY G d I I P G 442
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 484 I T NHN YYTNSFH I PVY YN I QAIN KI RL E GPF H A L CN GGHI TY IEL DG a A MH N KK AL KQI V QAM A EH GV G Y GS IN H P V D R C 563
Cdd:cd01675 443 V T DKP YYTNSFH V PVY ED I DPFE KI DI E AKL H P L TT GGHI LH IEL GE - A KP N PE AL EAL V KKA A KR GV I Y FG IN T P I D I C 521
570 580 590
....*....|....*....|....*....|....*..
gi 446862820 564 KC C S Y H G - VI G NE CP S CG N ED ean I E R I R RITGYL VG 599
Cdd:cd01675 522 ND C G Y I G e GE G FK CP K CG S ED --- V E V I S RITGYL GP 555
PRK09263
PRK09263 anaerobic ribonucleoside triphosphate reductase; Provisional
5-618
5.48e-142
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain]
Cd Length: 711
Bit Score: 428.91
E-value: 5.48e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 5 N T RGE EE LMKV feti VHGNEQDLMQ ENAN V D GR spmg V MG T F ---- A SESA K Y YA VEN LL SDQ V KK A INENILYP HDLD F 80
Cdd:PRK09263 95 A T DLN EE IRGL ---- IEQSNEAVLN ENAN K D SK ---- V FS T Q rdll A GIVS K H YA LRH LL PRD V VN A HEKGDIHY HDLD Y 166
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 81 YA - TGTTT C SQ I P L AQ ML A NGF HT G HGHMRQ P QD I KS A L A - LSS II F Q ANQN m Q H GG QSFALF D ID LAPY VR K TI E R H K K 158
Cdd:PRK09263 167 SP f FPMFN C CL I D L KG ML T NGF KI G NAEIES P KS I QT A T A v TAQ II A Q VASS - Q Y GG CTINRI D EV LAPY AE K SY E K H L K 245
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 159 RLQSY p LTK E QI E EFSWKE TE NDT Y Q A CEAFVHNS N SM H S r GG GQ V PF ISINY G TD TS K E G R MLI K QL L KATQ AGLGK - G 237
Cdd:PRK09263 246 DAEEW - VIE E KA E AYARAR TE KEI Y D A MQSLEYEI N TL H T - SN GQ T PF VTLGF G LG TS W E S R LIQ K AI L RNRI AGLGK e R 323
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 238 E T P IFP IQI F KM K K G V N FEES DPNYD LFE LALE TTAE R LF P NFSFL D apf NA V HYD G rpe S EVCY MGCR T -- RVMSNIH G 315
Cdd:PRK09263 324 K T A IFP KLV F AI K D G L N LKPG DPNYD IKQ LALE CATK R MY P DILNY D --- KI V ELT G --- S FKTP MGCR S fl QGWKDEN G 397
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 316 EE TAI GR G NL SFTSI NL VKL AL IS - G SKEA F F E A L NYY L D L GI K Q L LE R FAYQCTKRA R DFQF LY SQ G VW rg G ET L HPE D 394
Cdd:PRK09263 398 EE VHD GR N NL GVVTL NL PRI AL EA k G DEDK F W E I L DER L E L AK K A L MT R IERLKGAKP R VAPI LY MY G AF -- G VR L KAD D 475
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 395 S V ASIL K Q G -- T L S I G F IGL A E CLV AL T G KHHGEDE E SWKLGYE I ISF M R D RM D KATE E HQLN FS VIA TP A E G L SGK F VK 472
Cdd:PRK09263 476 D V DELF K N G ra T I S L G Y IGL Y E TIN AL Y G GSWEVNP E AKAFALA I VKR M K D AC D QWKK E TGYG FS LYS TP S E S L TDR F CR 555
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 473 K D RKE FGVI S GIT NHN YYTNSFH IP V YYNIQAIN K IRL E G P FHA L CN GG H I T Y I E LDG aa M - HN K KAL KQIVQAMAEH g V 551
Cdd:PRK09263 556 L D TEK FGVI P GIT DKG YYTNSFH YD V RKKVNPFE K LDF E K P YPP L AS GG F I H Y C E YPN -- L q HN L KAL EAVWDYSYDR - V 632
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446862820 552 GY GSI N H P V D R C KC C SYH G VI ----- G NE CP S CGN E D EANIERI RR IT GYL VGDMSK - W N SAKRS E EID RVKH 618
Cdd:PRK09263 633 GY LGT N T P I D E C YE C GFT G EF ectek G FT CP K CGN H D PKTVSVT RR TC GYL GNPDAR p F N HGRQE E IKR RVKH 705
PRK08270
PRK08270 ribonucleoside triphosphate reductase;
29-584
1.91e-32
ribonucleoside triphosphate reductase;
Pssm-ID: 236212 [Multi-domain]
Cd Length: 656
Bit Score: 132.66
E-value: 1.91e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 29 Q EN A N V d G R S PM G VMGTFASESAKY Y AVENLLSDQVKK A INENI L YP HDLD F --- Y atgttt C SQIP L AQM L AN GF HTGH 105
Cdd:PRK08270 117 N EN S N M - G Y S LQ G LILNISGKVTAN Y WLNKVYPPEIGE A HRNGD L HI HDLD M lsg Y ------ C AGWS L RDL L LE GF NGVP 189
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 106 G H mrqpqd IK S ALA -- LS S IIF Q - A N ----- QN MQH G G Q S F AL FD ID LAP Y VRK tierhk KR L q SY PLT K EQ I E EF swke 177
Cdd:PRK08270 190 G K ------ VE S KPP kh FR S ALG Q i V N flgtl QN EWA G A Q A F SS FD TY LAP F VRK ------ DG L - SY KEV K QA I Q EF ---- 252
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 178 tendtyqaceaf V H N S N S m H SR G G G Q V PF ISI ------------------------ N YG t D TS KE GR M LIKQLLKATQA G 233
Cdd:PRK08270 253 ------------ V F N L N V - P SR W G F Q T PF TNL tfdltvpedlkdqpviiggeemdf T YG - D FQ KE MD M INRAFIEVMLE G 318
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 234 LGK G ETPI FPI QIFKMK K gv N F EESDP N Y DL F ela L E T TA ERLF P N F S fldapf N AVHY D GR PE s E V CY M G CR TR v MSNI 313
Cdd:PRK08270 319 DAN G RVFT FPI PTYNIT K -- D F DWDSE N A DL L --- F E M TA KYGL P Y F Q ------ N FINS D LK PE - D V RS M C CR LQ - LDLR 385
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 314 H ----------- G E E T aigr G NLSFTS INL VK L ALI S GSK E A FF EA L NYYL DL G ---------- I KQ L LERFA Y QC TKR a 372
Cdd:PRK08270 386 E lrkrggglfgs A E L T ---- G SIGVVT INL PR L GYL S KDE E E FF AR L DELM DL A kdsleikrkv I ER L TDKGL Y PY TKR - 460
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 373 rdfq F L ysq G VW R G getl H pedsvasilkqgt L S - IG FI G LA E CLVALT GK HHG e D EE SWKLGYEIISF MR D R MDKAT EE 451
Cdd:PRK08270 461 ---- Y L --- G TL R N ---- H ------------- F S t IG LN G MN E ACLNFL GK DIT - T EE GRAFALRVLDH MR E R LVEFQ EE 515
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 452 HQLNFSVI ATPAEG LSGKFV K K D R K EFGV I -- S G ITNHN YYTNS FHI PV Y Y NIQAINKIR L EGPFHALCN GG --- H I t Y I 526
Cdd:PRK08270 516 TGNLYNLE ATPAEG TTYRLA K E D K K RYPD I it A G TDEEP YYTNS TQL PV G Y TDDPFEALE L QDELQTKYT GG tvf H L - Y L 594
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446862820 527 eld G A A MHNKK A L K QI V QAMA E H - GVG Y GS I N h P VDR ck C C SY HG VIGN E --- CP S CG N E D E 584
Cdd:PRK08270 595 --- G E A ISDAE A C K KL V KKAL E N y RLP Y IT I T - P TFS -- I C PK HG YLSG E hef CP K CG E E T E 650
PRK08271
PRK08271 anaerobic ribonucleoside triphosphate reductase; Provisional
303-611
4.79e-17
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 181342 [Multi-domain]
Cd Length: 623
Bit Score: 84.67
E-value: 4.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 303 MG CR T R VMSNIH G EETAI G R G NLSFT S ----- INL VKL A LISGSKEA F F E A L NYYL D ------ L GIKQLL E R fa YQ ctkr 371
Cdd:PRK08271 324 SC CR L R NEISDN G FSYSL G A G GVNTG S invit INL PRI A QEARDRDD F L E I L RERV D kihkyq L AYREIM E E -- RI ---- 397
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 372 A RDFQF LY SQ G VW rggetlhpedsva S IL KQ g T L S IG FI G LA E CLVAL t G KHH G ED EE SWKLGY E IISFMRDRMD KA TE E 451
Cdd:PRK08271 398 A AGMLP LY DA G FI ------------- S LD KQ - F L T IG IN G MV E AAEFM - G LTV G YN EE YKDFVQ E VLKVIYEANE KA SK E 462
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 452 HQLN F SVIAT PAE G L SG K FV K K DR K - EF GV IS gi TNH N Y Y tns FHIPVYY N IQ A IN K IR L E G - PFHALCN GG HITYIE LD 529
Cdd:PRK08271 463 YGFT F NTEFV PAE N L GV K LA K W DR E d GY GV PR -- QCY N S Y --- SYVVEDA N TD A LD K FK L H G k ELDKYLS GG SALHLN LD 537
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 530 GAA mh NKKALKQIVQAM A EH G VG Y GSI N HPVDR C KC C SYHGV - I G NE CP S CG N E dea NI ERIR R IT GYL V g DM S KWNSAK 608
Cdd:PRK08271 538 ERL -- SEEGYRKLLNIA A KT G CN Y FAF N VKITI C ND C HHIDK r T G KR CP I CG S E --- NI DYYT R VI GYL K - RV S AFSKVR 611
...
gi 446862820 609 RS E 611
Cdd:PRK08271 612 QK E 614
PRK08579
PRK08579 anaerobic ribonucleoside triphosphate reductase; Provisional
7-611
9.44e-15
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236303 [Multi-domain]
Cd Length: 625
Bit Score: 77.48
E-value: 9.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 7 RG E EELMKVF E TIVHG N EQ D LM q ENAN vdg R S P m G VM G T FA -- S E S A KYYAVEN LL SDQVKK A INENIL Y P H D L D f Y ATG 84
Cdd:PRK08579 4 LM E MKKRDII E EYAAW N SL D VN - ENAN --- R Y P - G PT G F FA yv L E E A LKESLVS LL PEPGLE A HFSGDI Y I H K L P - Y SLY 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 85 TTT C SQIPLAQM L AN G fhtghgh MRQ P Q d I K S AL A LSSII F Q --- AN Q -- N MQH --- G G Q S F ALFDIDLA P YV RK ti ER h 156
Cdd:PRK08579 78 IPY C TGHSISRL L EK G ------- LKT P T - I I S RP A RHFDT F V dhv AN Y li T MQH yft G A Q A F SSVEWYAG P FI RK -- DG - 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 157 kkrlqsyp L TKEQ I E efswketendty Q ACEAF V H N S N s MH SR G G G Q V PF ISINYGT D TS K ------------------- 217
Cdd:PRK08579 147 -------- L DYRK I K ------------ Q NIQRL V Y N L N - YP SR V G M Q T PF TNFTVTL D AP K kmlegdyavydgkkvgplg 205
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 218 ---- E GRMLIKQ L LKATQA G LGK G ETPI FPI QIFKMKK gv NFEES DP ny DL FE LALE T T A E R lf PN F SF L DA pf NA V H yd 293
Cdd:PRK08579 206 eyee E AKLFLLA L TEVLRE G DAL G QPFT FPI PTLMTTA -- KMLWD DP -- EV FE AVFT T A A K R -- GS F YW L NT -- RV V D -- 275
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 294 gr P ESEVC y M G CR TRVMS N ---------------- IHG EE TAIGR ---------------- G NLSF T SI NL VKL AL IS - G 340
Cdd:PRK08579 276 -- P DASYA - M C CR INIDK N elmyafgvggksrrdl EDA EE EYLEK lekqrfgglwampdit G SVNV T TV NL PRI AL EA r G 352
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 341 SKEA F F E ALNYY L D L g IKQL L ER F AYQCT K RARDFQFL YS Q gvwrggetlhpeds VASI L KQGTL S ---- IG F IGL A E CL 416
Cdd:PRK08579 353 DDDK F W E LYEER L E L - VRIT L DW F RERYV K LLKTYPEM YS M -------------- IKEY L EEFPS S hfnt IG I IGL P E AA 417
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 417 VALT G K ------- HHGEDE E SWK L GYEIIS F MRDRMDKATE E HQLNFS V IAT P A E GLSG K FVK KD R K E F GVI sgitn HN Y 489
Cdd:PRK08579 418 AIYL G E pklwteg SRRDWL E AAE L MKKMVE F AVEKAREWMK E TGTPWN V EEV P G E SAAA K LAI KD L K L F PEL ----- RE Y 492
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 490 -------- Y TN S F h I P V Y YNIQAINK I RL E GPFHALCN GG HITY I E L DGAA mh NKK AL KQIVQAMAEHGVG Y G S INHPVD 561
Cdd:PRK08579 493 lsdpenpi Y ST S I - A P Y Y GPLELWDR I EI E EKVQQEFT GG VMMH I F L GEEP -- DPE AL AKLTKRIMNTKLV Y W S YTPAIT 569
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 446862820 562 R C KC C -- S YH G VI g NE CP S CG N ED ean I E RIR RI T GY L v GDMSK WN SAKRS E 611
Cdd:PRK08579 570 V C NK C gr S TT G LY - TR CP R CG S ED --- V E VWS RI I GY Y - RPLKN WN PYRKK E 616
RNR_PFL
cd00576 Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...
66-550
4.32e-13
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain]
Cd Length: 401
Bit Score: 71.41
E-value: 4.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 66 K A INENILYPHDL D FYA TG ttt C SQIPLAQM L AN G FH tgh G HMRQPQD I KS A LAL - SS II FQ A NQ N MQH GG Q SFA LFDID 144
Cdd:cd00576 6 E A VKSGVITVGRP D LPF TG --- C VLVDYGDS L DP G IK --- G VNETAKS I NE A IQK t YQ II AL A AS N QNG GG V SFA RASSI 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 145 L A PY VRKTIERHKK rlqsypltkeqieefswke TE N D TYQ A CE AF VHNSNSM h SR G G G QVPFISINY G TDTSKE G RMLIK 224
Cdd:cd00576 80 L S PY GSRDYAKGSG ------------------- TE T D AVE A AD AF NLALKEV - GQ G N G RTGAATGFI G GVHKGK G DKISQ 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 225 QL L KATQ A GL G K G ETPI FP --- IQIFKM K K G VN fees DPNYD L FE L AL E TTAERLF P NFSFLDAPF navhydgrpesevc 301
Cdd:cd00576 140 EF L NLAL A NG G E G IPLN FP nls VRVSSD K P G IL ---- VKAVE L KQ L IA E EARKTGS P GIFNDELCN -------------- 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 302 ymgcrtrvmsnihgeetaigrgnls FT S I NL VKLAL -- I S GS KEAFF E A L NY yldlgikqller F A YQCT k RA r DFQFLY 379
Cdd:cd00576 202 ------------------------- LV S L NL ARIME ka I N GS MDVVL E E L EE ------------ L A FLAV - RA - LDCVID 242
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 380 S QGVWRGGET L hpedsva SILKQG T LSI G FI G L A EC L VA L t G KHHGE D E E SWK L GY E IISFMRDRMD KAT E E HQL NF SVI 459
Cdd:cd00576 243 S HDERIPTIE L ------- GGDERR T VGL G IA G V A DL L IK L - G LEKVG D P E ADD L AA E LVDQLKKHLV KAT N E RGF NF LLG 314
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 460 AT P A E GL S GK fvkkdrkefgvisgitnh NYY TN SFHIPV -- YYNIQAIN ----- KIRLEGPFHALCNG G HITY I ELDGA A 532
Cdd:cd00576 315 LS P S E SN S SG ------------------ APA TN GVSPSR g* IAIVLNGD igpee SLASVAILQFYADN G ISDT I TIPDS A 376
490
....*....|....*...
gi 446862820 533 MHNKKA L KQ I VQ A M A EHG 550
Cdd:cd00576 377 TNLDQL L AV I DG A A A IKT 394
Gly_radical
pfam01228 Glycine radical;
506-598
5.83e-13
Glycine radical;
Pssm-ID: 426140 [Multi-domain]
Cd Length: 106
Bit Score: 65.27
E-value: 5.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446862820 506 NKIRL EGP FHA L CNG G H I T Y - I ELDG A a MH N K K A L KQIVQA ma EHGV GY GSI N HPV D RCKCCSY H G --- V IGN E - C P SCG 580
Cdd:pfam01228 9 HGADF EGP TAV L NSV G K I D Y e V ELDG I - SL N Q K F L PAVLGY -- YDEE GY ANL N TLI D TYFEGGH H L qfn V VDR E t L P DAQ 85
90
....*....|....*...
gi 446862820 581 NED E ANIERIR R IT GY LV 598
Cdd:pfam01228 86 KHP E KYPDLTV R VS GY SA 103
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
