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Conserved domains on  [gi|446868929|ref|WP_000946185|]
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MULTISPECIES: SH3 domain-containing protein [Bacillus]

Protein Classification

SH3 domain-containing protein( domain architecture ID 707922)

Src Homology 3 (SH3) domain-containing protein plays versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others

CATH:  2.30.30.40
Gene Ontology:  GO:0005515|GO:0070064
PubMed:  28510178|11256992|1639195
SCOP:  4000369

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YraI super family cl28549
Uncharacterized conserved protein YraI [Function unknown];
9-107 3.39e-06

Uncharacterized conserved protein YraI [Function unknown];


The actual alignment was detected with superfamily member COG4991:

Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 41.97  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446868929   9 TLLTAFIFTLFTFNGSAFAATNTTENETVvaacakggtvgtygaKMRSGYTVGSPVLHTFTSGQKITgtwvtgeyVQGhY 88
Cdd:COG4991    3 RALLAAALALLLLAPAAAAAATAVATDDL---------------NLRSGPGTGYPVVGTLPAGATVT--------VLG-C 58

                         90
                 ....*....|....*....
gi 446868929  89 SNSKQWLKVTYKGMTGYVS 107
Cdd:COG4991   59 TSGGGWCKVSYGGQRGWVS 77
 
Name Accession Description Interval E-value
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
9-107 3.39e-06

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 41.97  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446868929   9 TLLTAFIFTLFTFNGSAFAATNTTENETVvaacakggtvgtygaKMRSGYTVGSPVLHTFTSGQKITgtwvtgeyVQGhY 88
Cdd:COG4991    3 RALLAAALALLLLAPAAAAAATAVATDDL---------------NLRSGPGTGYPVVGTLPAGATVT--------VLG-C 58

                         90
                 ....*....|....*....
gi 446868929  89 SNSKQWLKVTYKGMTGYVS 107
Cdd:COG4991   59 TSGGGWCKVSYGGQRGWVS 77
SH3_3 pfam08239
Bacterial SH3 domain;
51-111 4.14e-04

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 35.69  E-value: 4.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446868929   51 GAKMRSGYTVGSPVLHTFTSGQKITgtwVTGEYVQGhysnskqWLKV-TYKGMTGYVSHTTL 111
Cdd:pfam08239   2 GLNVRSGPSTSSEVVGTLPKGEKVE---VLEEQGGG-------WYKVrTYDGYEGWVSSSYL 53
 
Name Accession Description Interval E-value
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
9-107 3.39e-06

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 41.97  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446868929   9 TLLTAFIFTLFTFNGSAFAATNTTENETVvaacakggtvgtygaKMRSGYTVGSPVLHTFTSGQKITgtwvtgeyVQGhY 88
Cdd:COG4991    3 RALLAAALALLLLAPAAAAAATAVATDDL---------------NLRSGPGTGYPVVGTLPAGATVT--------VLG-C 58

                         90
                 ....*....|....*....
gi 446868929  89 SNSKQWLKVTYKGMTGYVS 107
Cdd:COG4991   59 TSGGGWCKVSYGGQRGWVS 77
SH3_3 pfam08239
Bacterial SH3 domain;
51-111 4.14e-04

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 35.69  E-value: 4.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446868929   51 GAKMRSGYTVGSPVLHTFTSGQKITgtwVTGEYVQGhysnskqWLKV-TYKGMTGYVSHTTL 111
Cdd:pfam08239   2 GLNVRSGPSTSSEVVGTLPKGEKVE---VLEEQGGG-------WYKVrTYDGYEGWVSSSYL 53
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 54-107 9.08e-03

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 33.56  E-value: 9.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446868929  54 MRSGYTVGSPVLHTFTSGQKITGTWVTGEyvqghysnskqWLKVTY-KGMTGYVS 107
Cdd:COG3103   16 VRSGPGTSYRIVGTLPKGEKVTVLGRSGG-----------WYKVRYsNGKTGWVS 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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