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Conserved domains on  [gi|446887245|ref|WP_000964501|]
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autotransporter outer membrane beta-barrel domain-containing protein [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
autotrans_barl super family cl36898
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
5-62 2.76e-08

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


The actual alignment was detected with superfamily member TIGR01414:

Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 47.76  E-value: 2.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446887245    5 RLGDESVNASIDGAAFRVGAGVQADITKNMGAYASLDYTKGDDIENPLQGVVGINVTW 62
Cdd:TIGR01414 374 RVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
 
Name Accession Description Interval E-value
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
5-62 2.76e-08

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 47.76  E-value: 2.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446887245    5 RLGDESVNASIDGAAFRVGAGVQADITKNMGAYASLDYTKGDDIENPLQGVVGINVTW 62
Cdd:TIGR01414 374 RVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
4-62 1.17e-04

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 37.62  E-value: 1.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446887245   4 LRLGDESVNASIDGAAFRVGAGVQADITKNMGAYASLDYTKGDD--IENPLQGVVGINVTW 62
Cdd:COG3468  786 VTVNGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDgyDSSDTSGNLGVRYSF 846
 
Name Accession Description Interval E-value
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
5-62 2.76e-08

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 47.76  E-value: 2.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446887245    5 RLGDESVNASIDGAAFRVGAGVQADITKNMGAYASLDYTKGDDIENPLQGVVGINVTW 62
Cdd:TIGR01414 374 RVNGVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
4-62 1.17e-04

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 37.62  E-value: 1.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446887245   4 LRLGDESVNASIDGAAFRVGAGVQADITKNMGAYASLDYTKGDD--IENPLQGVVGINVTW 62
Cdd:COG3468  786 VTVNGVSFSQDGSGTWGELGLGVTGQLNKNLSLYGDVGYQTGLDgyDSSDTSGNLGVRYSF 846
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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