NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446900423|ref|WP_000977679|]
View 

MULTISPECIES: diacylglycerol kinase [Bacillus]

Protein Classification

diacylglycerol kinase family lipid kinase( domain architecture ID 11486557)

diacylglycerol kinase family lipid kinase such as diacylglycerol (DAG) kinase, which catalyzes the phosphorylation of DAG into phosphatidic acid and is involved in the production of lipoteichoic acid

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK13337 PRK13337
putative lipid kinase; Reviewed
 2-301 0e+00

putative lipid kinase; Reviewed


:

Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 588.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   2 MKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:PRK13337   1 MKRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  82 EFRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQLA 161
Cdd:PRK13337  81 ENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 162 YYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQR 241
Cdd:PRK13337 161 YYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIATLALR 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 242 GEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIYHCLELFVPEHQEDAL 301
Cdd:PRK13337 241 GEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAEFENLYRHIEVFVPKDQENAE 300
 
Name Accession Description Interval E-value
PRK13337 PRK13337
putative lipid kinase; Reviewed
 2-301 0e+00

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 588.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   2 MKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:PRK13337   1 MKRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  82 EFRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQLA 161
Cdd:PRK13337  81 ENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 162 YYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQR 241
Cdd:PRK13337 161 YYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIATLALR 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 242 GEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIYHCLELFVPEHQEDAL 301
Cdd:PRK13337 241 GEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAEFENLYRHIEVFVPKDQENAE 300
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 2-286 2.90e-123

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 354.12  E-value: 2.90e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423    2 MKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   82 EFRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTY-FINIAGGGRITELTYEVPSKLKTVLGQL 160
Cdd:TIGR00147  81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  161 AYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQ 240
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 446900423  241 RGEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIY 286
Cdd:TIGR00147 241 EGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILP 286
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-295 9.81e-122

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 350.31  E-value: 9.81e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   1 MMKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVG 80
Cdd:COG1597    1 AMMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  81 HefRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQL 160
Cdd:COG1597   81 T--GPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 161 AYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQ 240
Cdd:COG1597  159 AYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLL 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446900423 241 RGEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDA-PMEFENIYHCLELFVPE 295
Cdd:COG1597  239 RGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLAtPLEFEVLPGALRVLVPA 294
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 4-128 5.57e-55

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 174.31  E-value: 5.57e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423    4 RARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGHEF 83
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 446900423   84 RPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRA 128
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 7-125 5.14e-12

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 61.93  E-value: 5.14e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423     7 IIYNPTSGrelfKKSLPEVLQKLEQAG-----YETSchaTTGPGDATVAARQAADrkFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:smart00046   2 VFVNPKSG----GGKGEKLLRKFRLLLnprqvFDLT---KKGPAVALVIFRDVPD--FNRVLVCGGDGTVGWVLNALDKR 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 446900423    82 EFR---PKFGIIPVGTTNDFARAIGVP------RSIEEAADIICeGKTVPLDL 125
Cdd:smart00046  73 ELPlpePPVAVLPLGTGNDLARSLGWGggydgeKLLKTLRDALE-SDTVKLDR 124
 
Name Accession Description Interval E-value
PRK13337 PRK13337
putative lipid kinase; Reviewed
 2-301 0e+00

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 588.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   2 MKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:PRK13337   1 MKRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  82 EFRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQLA 161
Cdd:PRK13337  81 ENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 162 YYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQR 241
Cdd:PRK13337 161 YYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIATLALR 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 242 GEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIYHCLELFVPEHQEDAL 301
Cdd:PRK13337 241 GEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAEFENLYRHIEVFVPKDQENAE 300
PRK13055 PRK13055
putative lipid kinase; Reviewed
 1-293 2.07e-138

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 394.36  E-value: 2.07e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   1 MMKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATT-GPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLV 79
Cdd:PRK13055   1 MQKRARLIYNPTSGQEIMKKNVADILDILEQAGYETSAFQTTpEPNSAKNEAKRAAEAGFDLIIAAGGDGTINEVVNGIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  80 GHEFRPKFGIIPVGTTNDFARAIGVPR-SIEEAADIICEGKTVPLDLGRAN-DTYFINIAGGGRITELTYEVPSKLKTVL 157
Cdd:PRK13055  81 PLEKRPKMAIIPAGTTNDYARALKIPRdNPVEAAKVILKNQTIKMDIGRANeDKYFINIAAGGSLTELTYSVPSQLKSMF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 158 GQLAYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAAT 237
Cdd:PRK13055 161 GYLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTANLFELLHLMA 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446900423 238 QA-QRGEHINNPKVLYTQANRIKVHS--PDKLMINLDGEYGGDAPMEFENIYHCLELFV 293
Cdd:PRK13055 241 LIlNGGKHIDDPRVIYIKTSKLTIEPlgDDRLMVNLDGEYGGDAPMTFENLKQHIEFFA 299
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 2-286 2.90e-123

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 354.12  E-value: 2.90e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423    2 MKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   82 EFRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTY-FINIAGGGRITELTYEVPSKLKTVLGQL 160
Cdd:TIGR00147  81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  161 AYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQ 240
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 446900423  241 RGEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIY 286
Cdd:TIGR00147 241 EGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILP 286
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-295 9.81e-122

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 350.31  E-value: 9.81e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   1 MMKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVG 80
Cdd:COG1597    1 AMMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  81 HefRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQL 160
Cdd:COG1597   81 T--GPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 161 AYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQ 240
Cdd:COG1597  159 AYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLL 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446900423 241 RGEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDA-PMEFENIYHCLELFVPE 295
Cdd:COG1597  239 RGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLAtPLEFEVLPGALRVLVPA 294
PRK13059 PRK13059
putative lipid kinase; Reviewed
 2-294 2.92e-68

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 214.13  E-value: 2.92e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   2 MKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTgPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:PRK13059   1 MKKVKFIYNPYSGENAIISELDKVIRIHQEKGYLVVPYRIS-LEYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  82 EFRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQLA 161
Cdd:PRK13059  80 NIDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDKYFINVASTGLFTDVSQKTDVNLKNTIGKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 162 YYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFeKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQR 241
Cdd:PRK13059 160 YYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNF-NLAYKAEVDDGLLDVIIIKACPIIDLIPLFIKVLK 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446900423 242 GEHINNPK-VLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIYHCLELFVP 294
Cdd:PRK13059 239 GEHLEDVNgLIYFKTDKLEIESNEEIVTDIDGERGPDFPLNIECIKGGLKVLGI 292
PRK13054 PRK13054
lipid kinase; Reviewed
 1-273 3.50e-59

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 191.24  E-value: 3.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   1 MMKRARIIYNptsGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVG 80
Cdd:PRK13054   2 TFPKSLLILN---GKSAGNEELREAVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  81 H--EFRPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRAND-TYFINIAGGGRITELTYEVPSKLKTVL 157
Cdd:PRK13054  79 LegDARPALGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDrTYFINMATGGFGTRVTTETPEKLKAAL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 158 GQLAYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKkgSIADLIKAAT 237
Cdd:PRK13054 159 GGVAYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILP--APQELLPTLL 236

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446900423 238 QAQRGEHINNPKVLYTQANRIKVHSPDKLMINLDGE 273
Cdd:PRK13054 237 STLTGGSEDNPNIIRARLPWLEIQAPHELTFNLDGE 272
PRK13057 PRK13057
lipid kinase;
19-295 3.54e-57

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 185.51  E-value: 3.54e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  19 KKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRkFDVVIAAGGDGTLNEVVNGLVghEFRPKFGIIPVGTTNDF 98
Cdd:PRK13057  12 RAALAAARAALEAAGLELVEPPAEDPDDLSEVIEAYADG-VDLVIVGGGDGTLNAAAPALV--ETGLPLGILPLGTANDL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  99 ARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQLAYYLKGIEMLPSLHPTYV 178
Cdd:PRK13057  89 ARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHYFFNVASLGLSAELARRLTKELKRRWGTLGYAIAALRVLRRSRPFTA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 179 EIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQRGEHINNPKVLYTQANRI 258
Cdd:PRK13057 169 EIEHDGRTERVKTLQVAVGNGRYYGGGMTVAHDATIDDGRLDLYSLEVAHWWRLLALLPALRRGRHGEWPDVRAFRTTEL 248

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 446900423 259 KVHSPDKLMINLDGEYGGDAPMEFENIYHCLELFVPE 295
Cdd:PRK13057 249 ELRTRKPRPINTDGELTTYTPAHFRVLPKALRVLAPP 285
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 4-128 5.57e-55

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 174.31  E-value: 5.57e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423    4 RARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGHEF 83
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 446900423   84 RPKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRA 128
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
PRK00861 PRK00861
putative lipid kinase; Reviewed
 1-298 3.23e-47

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 160.17  E-value: 3.23e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   1 MMKRARIIYNPTSGRELFKKSLPEVLQKLEQAgYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVG 80
Cdd:PRK00861   1 MTRSACLIFNPVAGQGNPEVDLALIRAILEPE-MDLDIYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALIG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  81 HEFrpKFGIIPVGTTNDFARAIGVPRSIEEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLGQL 160
Cdd:PRK00861  80 TDI--PLGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVDVAYCNGQPMILLAGIGFEAETVEEADREAKNRFGIL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 161 AYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNT---RSV--GGFEKVAPyasiNDGLFDLLVLKKGSIADLIKA 235
Cdd:PRK00861 158 AYILSGLQQLRELESFEVEIETEDQIITTNAVAVTVANAappTSVlaQGPGAVIP----DDGLLDVTIVAPKNLAEAVAA 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446900423 236 ATQ----AQRGEHINNPKVLYTQANRIKV--HSPDKLMInlDGEYGGDAPMEFENIYHCLELFVPEHQE 298
Cdd:PRK00861 234 SYHllqtALQGNPAERDDIGYLRAKQVKIttDPPQKVVI--DGEVVGTTPIEIECLPRSLKVFAPLQAE 300
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 1-296 1.62e-31

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 119.12  E-value: 1.62e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   1 MMKRARIIYNPTSGRELFKKSLPEVLQKLEQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVG 80
Cdd:PRK11914   7 EIGKVTVLTNPLSGHGAAPHAAERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVISNALQVLAG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  81 HEFrpKFGIIPVGTTNDFARAIGVP-RSIEEAADIICEGKTVPLDLGRANDT-----YFINIAGGGrITELTYEVPSKLK 154
Cdd:PRK11914  87 TDI--PLGIIPAGTGNDHAREFGIPtGDPEAAADVIVDGWTETVDLGRIQDDdgivkWFGTVAATG-FDSLVTDRANRMR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 155 TVLGQLAYYLKGIEMLPSLHPTYVEIEYDG-KLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLI 233
Cdd:PRK11914 164 WPHGRMRYNLAMLAELSKLRPLPFRLVLDGtEEIVTDLTLAAFGNTRSYGGGMLICPNADHTDGLLDITMVQSASRTRLL 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446900423 234 KAATQAQRGEHINNPKVLYTQANRIKVHSPDklmINL--DGEYGGDAPMEFENIYHCLELFVPEH 296
Cdd:PRK11914 244 RLFPTVFKGTHVELDEVSTARAKTVHVECPG---INAyaDGDFACPLPAEISAVPGALQILRPRP 305
PRK12361 PRK12361
hypothetical protein; Provisional
 3-295 6.23e-27

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 110.10  E-value: 6.23e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   3 KRARIIYNPTSGRELFKKSLPEVLQKLEqAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGHE 82
Cdd:PRK12361 243 KRAWLIANPVSGGGKWQEYGEQIQRELK-AYFDLTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELVNTD 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  83 FrpKFGIIPVGTTNDFARAI-GVPRSI---EEAADIICEGKTVPLDLGRANDTYFINIAGGGRITELTYEVPSKLKTVLG 158
Cdd:PRK12361 322 I--TLGIIPLGTANALSHALfGLGSKLipvEQACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRERKNALG 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 159 QLAyYLKG-IEMLPSLHPTYVEIEYDGKLLQE-EITMFLITNtrsvggfekVAPYAS----------INDGLFDLLVLKK 226
Cdd:PRK12361 400 QLA-YLDGlWRAVNENETLTLTVTLDDAEPQTiSTHSLVVAN---------AAPFTSllaqgggepnMTDGLLDITWLDS 469

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446900423 227 G--------SIADLikaaTQAQRGEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIYHCLELFVPE 295
Cdd:PRK12361 470 GgepgeqllSLAEL----ALSGLGKEPEANKVHHAHAKKVTISSQKPIKYVIDGELFEDEDLTIEVQPASLKVFVPY 542
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 7-125 5.14e-12

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 61.93  E-value: 5.14e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423     7 IIYNPTSGrelfKKSLPEVLQKLEQAG-----YETSchaTTGPGDATVAARQAADrkFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:smart00046   2 VFVNPKSG----GGKGEKLLRKFRLLLnprqvFDLT---KKGPAVALVIFRDVPD--FNRVLVCGGDGTVGWVLNALDKR 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 446900423    82 EFR---PKFGIIPVGTTNDFARAIGVP------RSIEEAADIICeGKTVPLDL 125
Cdd:smart00046  73 ELPlpePPVAVLPLGTGNDLARSLGWGggydgeKLLKTLRDALE-SDTVKLDR 124
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 157-293 1.97e-10

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 58.36  E-value: 1.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  157 LGQLAYYLKGIEMLPSLHPTYVEIEYDGKLLQEEITMFLITNTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAA 236
Cdd:pfam19279  22 PGALSYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGGGMRIAPDARVDDGLLDVVVIEAASRRTLLRLL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446900423  237 TQAQRGEHINNPKVLYTQANRIKVHSPDKLMINLDGEYGGDAPMEFENIYHCLELFV 293
Cdd:pfam19279 102 PKVYDGRHVRLPQVEVLRGREVRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
 3-273 6.16e-07

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 50.63  E-value: 6.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   3 KRARIIYNPTSGRELFKKSLPEVLQKL-EQAGYETSCHATTGPGDATVAARQAADRKFDVVIAAGGDGTLNEVVNGLVGH 81
Cdd:PLN02958 112 KRLLVFVNPFGGKKSASKIFFDVVKPLlEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNGLLER 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423  82 E-----FRPKFGIIPVGTTNDFARA----IGVPRSIEEAADIICEGKTVPLDLGR--ANDTYF----------------- 133
Cdd:PLN02958 192 EdwktaIKLPIGMVPAGTGNGMAKSlldsVGEPCSATNAVLAIIRGHKCSLDVATilQGETKFfsvlmlawglvadidie 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 134 -----------INIAGGGRITELTYE------VPSKLKTVLGQLAYYlKGIEMLPSLHPTYVEIEYDG------KLLQEE 190
Cdd:PLN02958 272 sekyrwmgsarLDFYGLQRILCLRQYngrisfVPAPGFEAYGEPTSY-NGESTSKEESGKDKQHGYQGpdvkleNLDWRT 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423 191 ITMFLIT----NTRSVGGFEKVAPYASINDGLFDLLVLKKGSIADLIKAATQAQRGEHINNPKVLYTQANRI------KV 260
Cdd:PLN02958 351 IKGPFVSvwlhNVPWGGEDTLAAPDAKFSDGYLDLILIKDCPKLALLALMTKLSDGTHVKSPYVMYLKVKAFvlepgpRT 430

                        330
                 ....*....|....
gi 446900423 261 HSPDKL-MINLDGE 273
Cdd:PLN02958 431 DDPTKGgIIDSDGE 444
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
2-71 1.13e-05

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 45.90  E-value: 1.13e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446900423   2 MKRARIIYNPtsGRELFKKSLPEVLQKLEQAGYETSCHATTgpgDATVAARQAADRKFDVVIAAGGDGTL 71
Cdd:COG0061    1 MKRIAIVAKP--GKPEALEAAEELAELLEERGIEVVLDEDT---AVPGVPLEELGEEADLVIVLGGDGTL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH