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Conserved domains on  [gi|446902997|ref|WP_000980253|]
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MULTISPECIES: host cell division inhibitor Icd-like protein [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
phage_ICD_like NF033153
host cell division inhibitor Icd domain; Icd from temperate phage P1 inhibits cell division in ...
 143-190 5.24e-20

host cell division inhibitor Icd domain; Icd from temperate phage P1 inhibits cell division in its host. Homologous sequence is found in many other proteins, often as the C-terminal region of what appears to be a much larger protein. Putative phage proteins that contain this domain may be designated "host cell division inhibitor Icd-like protein". See PMID: 8491703 for a description of Icd. Many proteins with this domain also have the Ash domain described by PF10554, which also occurs in phage.


:

Pssm-ID: 467967  Cd Length: 48  Bit Score: 78.74  E-value: 5.24e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446902997 143 FVFVFAAVRRADRHPRICMLRTVAGDERSARRSLVRDYVLSLAARLPV 190
Cdd:NF033153   1 FTWRFAAVRRTDRTARPCVIRITADTEREARRQLARDYVLVFAARIPV 48
Phage_ASH super family cl11183
Ash protein family; This family was identified by Iyer and colleagues. It includes the Ash ...
 26-142 3.02e-17

Ash protein family; This family was identified by Iyer and colleagues. It includes the Ash protein from bacteriophage P4.


The actual alignment was detected with superfamily member pfam10554:

Pssm-ID: 431354  Cd Length: 105  Bit Score: 73.39  E-value: 3.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446902997   26 AVAKSAAGRENPSMLSATYDA-PCVFFCVAINATEHQIMvwrvvcragmilfaiACYTSESMVAQAGQPPGWPVSDNAGI 104
Cdd:pfam10554   2 ALAKSVAGRGNPNITKATVDAtPSVFAFFVDEALTHPSN---------------PAMDLFSMVAQAGQPKGWPVSFVAGY 66

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 446902997  105 LTPVWAIA-IERENSGDSVIYAVIGGCLMAMTLTPSHPE 142
Cdd:pfam10554  67 ANPVWVTAhKEIGVSGGSFTNKVKEAAYMATIPHCTQPK 105
 
Name Accession Description Interval E-value
phage_ICD_like NF033153
host cell division inhibitor Icd domain; Icd from temperate phage P1 inhibits cell division in ...
 143-190 5.24e-20

host cell division inhibitor Icd domain; Icd from temperate phage P1 inhibits cell division in its host. Homologous sequence is found in many other proteins, often as the C-terminal region of what appears to be a much larger protein. Putative phage proteins that contain this domain may be designated "host cell division inhibitor Icd-like protein". See PMID: 8491703 for a description of Icd. Many proteins with this domain also have the Ash domain described by PF10554, which also occurs in phage.


Pssm-ID: 467967  Cd Length: 48  Bit Score: 78.74  E-value: 5.24e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446902997 143 FVFVFAAVRRADRHPRICMLRTVAGDERSARRSLVRDYVLSLAARLPV 190
Cdd:NF033153   1 FTWRFAAVRRTDRTARPCVIRITADTEREARRQLARDYVLVFAARIPV 48
Phage_ASH pfam10554
Ash protein family; This family was identified by Iyer and colleagues. It includes the Ash ...
 26-142 3.02e-17

Ash protein family; This family was identified by Iyer and colleagues. It includes the Ash protein from bacteriophage P4.


Pssm-ID: 431354  Cd Length: 105  Bit Score: 73.39  E-value: 3.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446902997   26 AVAKSAAGRENPSMLSATYDA-PCVFFCVAINATEHQIMvwrvvcragmilfaiACYTSESMVAQAGQPPGWPVSDNAGI 104
Cdd:pfam10554   2 ALAKSVAGRGNPNITKATVDAtPSVFAFFVDEALTHPSN---------------PAMDLFSMVAQAGQPKGWPVSFVAGY 66

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 446902997  105 LTPVWAIA-IERENSGDSVIYAVIGGCLMAMTLTPSHPE 142
Cdd:pfam10554  67 ANPVWVTAhKEIGVSGGSFTNKVKEAAYMATIPHCTQPK 105
 
Name Accession Description Interval E-value
phage_ICD_like NF033153
host cell division inhibitor Icd domain; Icd from temperate phage P1 inhibits cell division in ...
 143-190 5.24e-20

host cell division inhibitor Icd domain; Icd from temperate phage P1 inhibits cell division in its host. Homologous sequence is found in many other proteins, often as the C-terminal region of what appears to be a much larger protein. Putative phage proteins that contain this domain may be designated "host cell division inhibitor Icd-like protein". See PMID: 8491703 for a description of Icd. Many proteins with this domain also have the Ash domain described by PF10554, which also occurs in phage.


Pssm-ID: 467967  Cd Length: 48  Bit Score: 78.74  E-value: 5.24e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446902997 143 FVFVFAAVRRADRHPRICMLRTVAGDERSARRSLVRDYVLSLAARLPV 190
Cdd:NF033153   1 FTWRFAAVRRTDRTARPCVIRITADTEREARRQLARDYVLVFAARIPV 48
Phage_ASH pfam10554
Ash protein family; This family was identified by Iyer and colleagues. It includes the Ash ...
 26-142 3.02e-17

Ash protein family; This family was identified by Iyer and colleagues. It includes the Ash protein from bacteriophage P4.


Pssm-ID: 431354  Cd Length: 105  Bit Score: 73.39  E-value: 3.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446902997   26 AVAKSAAGRENPSMLSATYDA-PCVFFCVAINATEHQIMvwrvvcragmilfaiACYTSESMVAQAGQPPGWPVSDNAGI 104
Cdd:pfam10554   2 ALAKSVAGRGNPNITKATVDAtPSVFAFFVDEALTHPSN---------------PAMDLFSMVAQAGQPKGWPVSFVAGY 66

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 446902997  105 LTPVWAIA-IERENSGDSVIYAVIGGCLMAMTLTPSHPE 142
Cdd:pfam10554  67 ANPVWVTAhKEIGVSGGSFTNKVKEAAYMATIPHCTQPK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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