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Conserved domains on  [gi|446906410|ref|WP_000983666|]
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helix-turn-helix transcriptional regulator [Escherichia coli]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10616232)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
5-72 1.75e-33

Winged helix-turn-helix DNA-binding;


:

Pssm-ID: 433408  Cd Length: 70  Bit Score: 109.63  E-value: 1.75e-33
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446906410   5 DWHPADIIAGLRKQRTSLAEVSRSAGLASATLANALSRSWPRGEKLIADVLETSPEIICPSRYFDDQG 72
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDDTG 68
 
Name Accession Description Interval E-value
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
5-72 1.75e-33

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 109.63  E-value: 1.75e-33
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446906410   5 DWHPADIIAGLRKQRTSLAEVSRSAGLASATLANALSRSWPRGEKLIADVLETSPEIICPSRYFDDQG 72
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDDTG 68
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
2-68 1.72e-30

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 102.22  E-value: 1.72e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446906410  2 MQQDWHPADIIAGLRKQRTSLAEVSRSAGLASATLANALSRSWPRGEKLIADVLETSPEIICPSRYF 68
Cdd:COG3423   3 KKKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
5-82 4.23e-29

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 99.27  E-value: 4.23e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906410  5 DWHPADIIAGLRKQRTSLAEVSRSAGLASATLANALSRSWPRGEKLIADVLETSPEIICPSRYFDDQG----NRTeRPMR 80
Cdd:PRK10344  7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQThefiDRT-QLMR 85


                ..
gi 446906410 81 KR 82
Cdd:PRK10344 86 SY 87
 
Name Accession Description Interval E-value
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
5-72 1.75e-33

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 109.63  E-value: 1.75e-33
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446906410   5 DWHPADIIAGLRKQRTSLAEVSRSAGLASATLANALSRSWPRGEKLIADVLETSPEIICPSRYFDDQG 72
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDDTG 68
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
2-68 1.72e-30

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 102.22  E-value: 1.72e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446906410  2 MQQDWHPADIIAGLRKQRTSLAEVSRSAGLASATLANALSRSWPRGEKLIADVLETSPEIICPSRYF 68
Cdd:COG3423   3 KKKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
5-82 4.23e-29

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 99.27  E-value: 4.23e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906410  5 DWHPADIIAGLRKQRTSLAEVSRSAGLASATLANALSRSWPRGEKLIADVLETSPEIICPSRYFDDQG----NRTeRPMR 80
Cdd:PRK10344  7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQThefiDRT-QLMR 85


                ..
gi 446906410 81 KR 82
Cdd:PRK10344 86 SY 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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