|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
230-581 |
9.56e-92 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 287.60 E-value: 9.56e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 230 IGQLSQAFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKDFLLRqiEDTFK 309
Cdd:COG5002 37 LLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLA--LLILL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 310 SKQTEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTIRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGI 389
Cdd:COG5002 115 AALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 390 VTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVW 469
Cdd:COG5002 195 ADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 470 -NYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLG 548
Cdd:COG5002 275 vLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLG 354
|
330 340 350
....*....|....*....|....*....|...
gi 446910524 549 LFICKMIIEEHGGSIDVKSELGKGTTFIIKLPK 581
Cdd:COG5002 355 LAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
182-580 |
1.85e-83 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 272.01 E-value: 1.85e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 182 VIFLTVTTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEhvdALSTSKNIR--- 258
Cdd:NF033092 184 LIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAFNNLTKRLQE---AQATTESERrkl 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 259 DSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDA--KDFL-LRQIEDTFK-----SKQTEMR-DLEMNARFFV--V 327
Cdd:NF033092 261 DSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVlgQSILdVLGLEEEYTlrdllEEQDSLLlDFSTEEEPLIlrA 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 328 TTSYIDKiEQGGKSGVVVTIRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDES 407
Cdd:NF033092 341 NFSVIQR-ESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALADGAWKDPELAPRFLGVTQNET 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 408 KRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDK------MKIKyrQQaddlglNMTF--NYCKKRVWNY-DMDRMDQ 478
Cdd:NF033092 420 ERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYiidrfeMILK--NK------NITFkrEFPKRDLWVEiDTDKITQ 491
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 479 VLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEE 558
Cdd:NF033092 492 VLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEA 571
|
410 420
....*....|....*....|..
gi 446910524 559 HGGSIDVKSELGKGTTFIIKLP 580
Cdd:NF033092 572 HGGRIWAESEEGKGTTIYFTLP 593
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
182-581 |
5.21e-81 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 260.66 E-value: 5.21e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 182 VIFLTVTTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRDSL 261
Cdd:COG5000 16 LLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERRRYLETI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 262 INSMVEGVLGINESRQIILSNKMANDIMDNIDEDA----------KDFLLRQIEDTFKSKQTEMRDLEMNAR--FFVVTT 329
Cdd:COG5000 96 LENLPAGVIVLDADGRITLANPAAERLLGIPLEELigkpleellpELDLAELLREALERGWQEEIELTRDGRrtLLVRAS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 330 SYIDkieqggkSGVVVTIRDMTNEHNLDQMK--KDFIANVSHELRTPISLLQGYTESIV----DGIVTEPDEIKESLAIV 403
Cdd:COG5000 176 PLRD-------DGYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLRrklaDKLEEDREDLERALDTI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 404 LDESKRLNRLVNELLNVARMDAeglsVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVW-NYDMDRMDQVLTN 482
Cdd:COG5000 249 IRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEvLADRDQLEQVLIN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 483 LIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKvdaarTRgKQGTGLGLFICKMIIEEHGGS 562
Cdd:COG5000 325 LLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFT-----TK-PKGTGLGLAIVKKIVEEHGGT 398
|
410
....*....|....*....
gi 446910524 563 IDVKSELGKGTTFIIKLPK 581
Cdd:COG5000 399 IELESRPGGGTTFTIRLPL 417
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
356-583 |
5.59e-76 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 240.96 E-value: 5.59e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 356 LDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQ 435
Cdd:COG2205 12 LERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 436 PIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVW-NYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKD 514
Cdd:COG2205 92 DLAELLEEAVEELRPLAEEKGIRLELDLPPELPLvYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSD 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446910524 515 TGTGIAPEHLQQVFDRFYKVDaaRTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE 583
Cdd:COG2205 172 NGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
354-582 |
4.88e-70 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 229.02 E-value: 4.88e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 354 HNLDQMKKDFIANVSHELRTPISLLQGYTESIVDgivTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKE 433
Cdd:COG0642 104 EEANEAKSRFLANVSHELRTPLTAIRGYLELLLE---ELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 434 VQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVW-NYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYI 512
Cdd:COG0642 181 PVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTvRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISV 260
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 513 KDTGTGIAPEHLQQVFDRFYKVDAARTRGkqGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKP 582
Cdd:COG0642 261 EDTGPGIPPEDLERIFEPFFRTDPSRRGG--GTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
259-575 |
1.76e-67 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 222.08 E-value: 1.76e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 259 DSLINSMVEGVLGINESRQIILSNKMANDIMD-NIDEDAK---DFLLRQIE--DTFKSKQTEmRDLEMNARFfvvttsYI 332
Cdd:TIGR02966 9 RAAAQALPDAVVVLDEEGQIEWCNPAAERLLGlRWPDDLGqriTNLIRHPEfvEYLAAGRFS-EPLELPSPI------NS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 333 DKIEQG-----GKSGVVVTIRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDES 407
Cdd:TIGR02966 82 ERVLEIriapyGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 408 KRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNyCKKRVWNY-DMDRMDQVLTNLIDN 486
Cdd:TIGR02966 162 QRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFE-IDGGVDVLgDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 487 ASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVK 566
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
....*....
gi 446910524 567 SELGKGTTF 575
Cdd:TIGR02966 321 SELGKGSTF 329
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
250-583 |
8.07e-45 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 162.71 E-value: 8.07e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 250 ALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMD---------NIDE--DAKDFLLRQIEDTFKSKQT----E 314
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGlsaeellgrPLAElfPEDSPLRELLERALAEGQPvterE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 315 MRDLEMNARFFVV--TTSYIDkiEQGGKSGVVVTIRDMTN-------EHNLDQMK--KDFIANVSHELRTPISLLQGYTE 383
Cdd:COG3852 81 VTLRRKDGEERPVdvSVSPLR--DAEGEGGVLLVLRDITErkrlereLRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 384 SIVDGIvtEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAeglsVNKEVQPIAALLDKMkikYRQQADDLGLNMTFny 463
Cdd:COG3852 159 LLEREL--PDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEVLERV---LELLRAEAPKNIRI-- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 464 ckkrVWNY---------DMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDI----------LYIKDTGTGIAPEHL 524
Cdd:COG3852 228 ----VRDYdpslpevlgDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyvrIEVIDNGPGIPEEIL 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446910524 525 QQVFDRFYkvdaaRTRGKqGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE 583
Cdd:COG3852 304 DRIFEPFF-----TTKEK-GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
348-581 |
8.66e-43 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 158.64 E-value: 8.66e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 348 RDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKeSLAIVLDESKRLNRLVNELLNVARMDAEG 427
Cdd:PRK11006 192 RDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREK-ALHTMREQTQRMEGLVKQLLTLSKIEAAP 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 428 LSVNKEVQPIAALLDKMkikyRQQADDLGLN---MTFNYCKK-RVWNyDMDRMDQVLTNLIDNASRYTKPGDEIAITCDE 503
Cdd:PRK11006 271 TIDLNEKVDVPMMLRVL----EREAQTLSQGkhtITFEVDNSlKVFG-NEDQLRSAISNLVYNAVNHTPEGTHITVRWQR 345
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446910524 504 NESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPK 581
Cdd:PRK11006 346 VPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
362-580 |
2.30e-42 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 158.32 E-value: 2.30e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 362 DFIANVSHELRTPISLLQGYTESIV----DGivtepDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPI 437
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLLGQTQVALsqprTG-----EEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 438 AALLDKMKIKYRQQADDLGLNMTFN-YCKKRVwnyDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTG 516
Cdd:TIGR01386 318 AAELAKVAEYFEPLAEERGVRIRVEgEGLVRG---DPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPG 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446910524 517 TGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKgTTFIIKLP 580
Cdd:TIGR01386 395 PGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
182-580 |
1.48e-41 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 156.14 E-value: 1.48e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 182 VIFLTVTTVFAFFLSSR-ITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHvdalstsknirds 260
Cdd:NF012163 170 VALALLLAALAAFLLARgLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKN------------- 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 261 linsmvegvlginesrqiilsnkmandimdnidedakdfllrqiedtfkskqtemrdlemnarffvvttsyidkieqggk 340
Cdd:NF012163 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 341 sgvvvtirdmtnehnlDQMKKDFIANVSHELRTPISLLQGYTESIVDGIvtePDEIKESLAIVLDESKRLNRLVNELLNV 420
Cdd:NF012163 237 ----------------EQMRRDFMADISHELRTPLAVLRAELEAIQDGI---RKFTPESLDSLQAEVGTLTKLVDDLHDL 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 421 ARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYTKPGDEIAIT 500
Cdd:NF012163 298 SMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHIS 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 501 CDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVK-SELGkGTTFIIKL 579
Cdd:NF012163 378 ASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAhSPLG-GLRIVVTL 456
|
.
gi 446910524 580 P 580
Cdd:NF012163 457 P 457
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
182-580 |
1.89e-40 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 153.25 E-value: 1.89e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 182 VIFLTVTTVFAFFLSSR-ITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEehvdalstsKNirds 260
Cdd:PRK10549 170 VALSTLLAALATFLLARgLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLE---------KN---- 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 261 linsmvegvlginesrqiilsnkmandimdnidedakdfllrqiedtfkskqtemrdlemnarffvvttsyidkieqggk 340
Cdd:PRK10549 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 341 sgvvvtirdmtnehnlDQMKKDFIANVSHELRTPISLLQGYTESIVDGiVTEPDeiKESLAIVLDESKRLNRLVNELLNV 420
Cdd:PRK10549 237 ----------------EQMRRDFMADISHELRTPLAVLRGELEAIQDG-VRKFT--PESVASLQAEVGTLTKLVDDLHQL 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 421 ARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYTKPGDEIAIT 500
Cdd:PRK10549 298 SLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHIS 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 501 CDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVK-SELGkGTTFIIKL 579
Cdd:PRK10549 378 AEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVEL 456
|
.
gi 446910524 580 P 580
Cdd:PRK10549 457 P 457
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
182-580 |
7.40e-40 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 153.59 E-value: 7.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 182 VIFLTVTTVF--AFFLSSRITKPLRRLRDQATRVsEGDYSYK-PSVTtkDEIGQLSQAFNQMSteieehvDALSTSKNIR 258
Cdd:PRK11360 195 VLAAGLVIGLllIFLLSRRFSANVDIIKDGLSTL-ENDLSTRlPPLP--GELGEISQAINNLA-------QALRETRSLN 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 259 DSLINSMVEGVLGINESRQIILSNKMANDIMDnidEDAKDFLLRQIEDTFKS-------------KQTEMRDLEM----- 320
Cdd:PRK11360 265 ELILESIADGVIAIDRQGKITTMNPAAEVITG---LQRHELVGKPYSELFPPntpfasplldtleHGTEHVDLEIsfpgr 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 321 -NARFFVVTTSYIdKIEQGGKSGVVVTIRDMTNEHNL-DQMKK--------DFIANVSHELRTPISLLQGYTESIVDGiv 390
Cdd:PRK11360 342 dRTIELSVSTSLL-HNTHGEMIGALVIFSDLTERKRLqRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQ-- 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 391 TEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAeglSVNKEVQpIAALLDKMKIKYRQQADDLGLNMTFNYCKK--RV 468
Cdd:PRK11360 419 TSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRE---SQWQPVS-LNALVEEVLQLFQTAGVQARVDFETELDNElpPI 494
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 469 WnYDMDRMDQVLTNLIDNASRYTKPGDEIAITCdENESEDILYIK--DTGTGIAPEHLQQVFDRFYkvdaarTRGKQGTG 546
Cdd:PRK11360 495 W-ADPELLKQVLLNILINAVQAISARGKIRIRT-WQYSDGQVAVSieDNGCGIDPELLKKIFDPFF------TTKAKGTG 566
|
410 420 430
....*....|....*....|....*....|....
gi 446910524 547 LGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:PRK11360 567 LGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
365-580 |
3.21e-39 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 147.25 E-value: 3.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 365 ANVSHELRTPISLLQGYTESIVDGI--VTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGL---SVNKEVQPIAA 439
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRRRLedEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEERepvDLNELIDEALE 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 440 LLdkmkikyRQQADDLGLNMTFNYCKKRVWNY-DMDRMDQVLTNLIDNAsRY---TKPGDEIAITCDENESEDILYIKDT 515
Cdd:COG4191 227 LL-------RPRLKARGIEVELDLPPDLPPVLgDPGQLEQVLLNLLINA-IDameEGEGGRITISTRREGDYVVISVRDN 298
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446910524 516 GTGIAPEHLQQVFDRFY--KvdaartRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:COG4191 299 GPGIPPEVLERIFEPFFttK------PVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
362-583 |
3.91e-39 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 150.32 E-value: 3.91e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 362 DFIANVSHELRTPISLLQGYTESIVDGIVTEPDE-IKESLAIVLDESKRLNRLVNELLNVARMDAEGL-----SVNKEVQ 435
Cdd:COG4251 284 QFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEeGREYLERIRDAAERMQALIDDLLAYSRVGRQELefepvDLNELLE 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 436 PIAALLDkMKIKYRQ---QADDLGlnmtfnyckkRVWnYDMDRMDQVLTNLIDNASRYTKPGD--EIAITCDENESEDIL 510
Cdd:COG4251 364 EVLEDLE-PRIEERGaeiEVGPLP----------TVR-GDPTLLRQVFQNLISNAIKYSRPGEppRIEIGAEREGGEWVF 431
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446910524 511 YIKDTGTGIAPEHLQQVFDRFYKVDAARTRgkQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE 583
Cdd:COG4251 432 SVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAP 502
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
476-579 |
7.23e-37 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 132.34 E-value: 7.23e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGkqGTGLGLFICKMI 555
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG--GTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 446910524 556 IEEHGGSIDVKSELGKGTTFIIKL 579
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
472-582 |
1.57e-36 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 132.00 E-value: 1.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 472 DMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDaARTRGKQGTGLGLFI 551
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 446910524 552 CKMIIEEHGGSIDVKSELGKGTTFIIKLPKP 582
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
245-580 |
5.91e-36 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 137.99 E-value: 5.91e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 245 EEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDA--------KDFL-LRQIEDTFKSKQTEM 315
Cdd:COG5807 16 NQEFKLTEDSEFKFKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYigktfveeKCILkDEQLYNKEAFDRIEI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 316 RDLEMNARFFVVTTSYIdkIEQGGKSGVVVTIRDMTNEHNLDQMK---------KDFIANVSHELRTPISLLQGYTESIV 386
Cdd:COG5807 96 SYLTKNGEFDEIIYPIY--YKDGVILGLITVYRDITKRKEAEDKLlrseklsvaGELAAGIAHEIRNPLTSIKGFLQLLQ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 387 DGIvtEPDEIKESLAIVLDESKRLNRLVNELLNVARMDA---EGLSVNKEVQPIAALLD------KMKIKYRQQADDLgl 457
Cdd:COG5807 174 ESR--EDSEREEYFNIIISEIDRINTIITELLVLSKPKKfnfKKLNLNDVLEDVIALLSteailkNISIKYDLADDEP-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 458 nmtfnyckkrVWNYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYkvdaa 537
Cdd:COG5807 250 ----------VINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFF----- 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446910524 538 rTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:COG5807 315 -TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
362-581 |
2.79e-35 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 138.75 E-value: 2.79e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 362 DFIANVSHELRTPISLLQGYTEsIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALL 441
Cdd:PRK09835 264 NFSADIAHEIRTPITNLITQTE-IALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEV 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 442 DKMKIKYRQQADDLGLNMTFNYCKKRVWNyDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAP 521
Cdd:PRK09835 343 GKVFDFFEAWAEERGVELRFVGDPCQVAG-DPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAP 421
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 522 EHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELgKGTTFIIKLPK 581
Cdd:PRK09835 422 EHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPR 480
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
363-580 |
1.72e-34 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 136.03 E-value: 1.72e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 363 FIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKesLAIVLDESKRLNRLVNELLNVARMDAEGL---SVNKEVQPIAA 439
Cdd:COG5808 244 FAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKY--FDIIQEEIQRINQIVSEFLVLGKPTAKKLeldDLNELIEEILS 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 440 LLD----KMKIKYRQQADDlglNMTFNYCKKrvwnydmDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDT 515
Cdd:COG5808 322 IIDseanLKNIRVEKQSLD---EPLHIKCDK-------DRIKQVLLNLIKNAIEAMKEGGKLTISIENDDEKAVIEVIDN 391
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446910524 516 GTGIAPEHLQQVFDRFYkvdaarTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:COG5808 392 GEGIPEDIIDEIFEPFV------TTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLP 450
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
249-581 |
3.81e-34 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 135.49 E-value: 3.81e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 249 DALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMA-------------NDIMDNIDEDAKDFLLRQIEDTFKSK---Q 312
Cdd:COG5809 134 EALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAAckllgisieeligKSILELIHSDDQENVAAFISQLLKDGgiaQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 313 TEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTIRDMTNEHNLDQMKKD---------FIANVSHELRTPISLLQGYTE 383
Cdd:COG5809 214 GEVRFWTKDGRWRLLEASGAPIKKNGEVDGIVIIFRDITERKKLEELLRKseklsvvgeLAAGIAHEIRNPLTSLKGFIQ 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 384 SIVDGIVtepDEIKESLAIVLDESKRLNRLVNELLNVAR---MDAEGLSVNKEVQPIA------ALLDKMKIKYRQQADD 454
Cdd:COG5809 294 LLKDTID---EEQKTYLDIMLSELDRIESIISEFLVLAKpqaIKYEPKDLNTLIEEVIpllqpqALLKNVQIELELEDDI 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 455 LGLnmtfnYCkkrvwnyDMDRMDQVLTNLIDNASRYTKPGDEIAI-TCDENESEDILYIKDTGTGIAPEHLQQVFDRFYk 533
Cdd:COG5809 371 PDI-----LG-------DENQLKQVFINLLKNAIEAMPEGGNITIeTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFY- 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446910524 534 vdaarTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPK 581
Cdd:COG5809 438 -----TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
132-581 |
2.91e-32 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 130.53 E-value: 2.91e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 132 GSSQTYILLGYPTKAQK-NSHSKYsgvFIYkDLKSIEDTNNAITIITIITAVIFLTVTTVFAFFLSSRITKPLRRLRDQA 210
Cdd:NF040691 148 GSSAPALVVGTPVTLPVaGNYELY---LLF-PLEDEQSTLALVRGTLLLGGLALVVLLGLIAWLVTRQVVAPVRSAARTA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 211 TRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSteieehvdalstsknirDSLinsmvegvlgineSRQIilsnkmandimd 290
Cdd:NF040691 224 ERFAAGDLSERMPVKGEDDLARLARSFNQMA-----------------DSL-------------QRQI------------ 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 291 nidedakdfllRQIEDtfkskqtemrdlemnarffvvttsyidkieqggksgvvvtirdmtnehnLDQMKKDFIANVSHE 370
Cdd:NF040691 262 -----------RQLEE-------------------------------------------------LSRLQQRFVSDVSHE 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 371 LRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQ 450
Cdd:NF040691 282 LRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQ 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 451 QADDLGLNMTFNYCKKRVwNYDMD--RMDQVLTNLIDNASRYTKpGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVF 528
Cdd:NF040691 362 LAERAGVELRVDAPGTPV-VAEVDprRVERVLRNLVVNAIEHGE-GKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVF 439
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 446910524 529 DRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPK 581
Cdd:NF040691 440 DRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPR 492
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
365-581 |
1.41e-31 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 125.49 E-value: 1.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 365 ANVSHELRTPISLLQGYTESIVDGiVTEPDEI-KESLaivLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDK 443
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDG-VFEPDPAlFKSL---LNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 444 MKIKYRQQADDLGLNMTFNYCKKRVWnYDMDRMDQVLTNLIDNASRYTKPGdEIAITCDENESEDILYIKDTGTGIAPEH 523
Cdd:NF012226 219 VLKMFEDRLEQAQLTIVLNLTATPVF-CDRRRIEQVLIALIDNAIRYANAG-KLKISSSVIQDDWILQIEDEGPGIAEEY 296
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 446910524 524 LQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGkGTTFIIKLPK 581
Cdd:NF012226 297 QQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQG-NSVFTIKLPA 353
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
476-580 |
1.80e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 117.59 E-value: 1.80e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTKPGdEIAITCD-ENESEDILYIK----DTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLF 550
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEG-EVTLRVSlEEEEEDGVQLRfsveDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 446910524 551 ICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
472-583 |
2.23e-30 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 114.77 E-value: 2.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 472 DMDRMDQVLTNLIDNASRYTKPGDEIAITCDENEsEDILYIKDTGTGIAPEHLQQVFDRFYKVDaarTRGKQGTGLGLFI 551
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 446910524 552 CKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE 583
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
301-582 |
9.09e-30 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 122.92 E-value: 9.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 301 LRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKI-EQGGKSGVVVTIRDMTNEHNLDQM--KKDFI-------ANVSHE 370
Cdd:COG5805 218 IESITEVWQEFIIEREIITKDGRIRYFEAVIVPLIdTDGSVKGILVILRDITEKKEAEELmaRSEKLsiagqlaAGIAHE 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 371 LRTPISLLQGYTESIVDGIvtepDEIKESLAIVLDESKRLNRLVNELLNVARMDA---EGLSVNKEVQPIAALLDKMKIK 447
Cdd:COG5805 298 IRNPLTSIKGFLQLLQPGI----EDKEEYFDIMLSELDRIESIISEFLALAKPQAvnkEKENINELIQDVVTLLETEAIL 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 448 YRQQ--ADDLGLNMtFNYCkkrvwnyDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQ 525
Cdd:COG5805 374 HNIQirLELLDEDP-FIYC-------DENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLK 445
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 446910524 526 QVFDRFYkvdaarTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKP 582
Cdd:COG5805 446 KLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
348-583 |
2.22e-28 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 120.65 E-value: 2.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 348 RDMTNEHNldQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEpdEIKESLAIVLDESKRLNRLVNELLNVARMDAEG 427
Cdd:TIGR02956 454 RAEAEEAN--RAKSAFLATMSHEIRTPLNGILGTLELLGDTGLTS--QQQQYLQVINRSGESLLDILNDILDYSKIEAGH 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 428 LSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKK--RVWNYDMDRMDQVLTNLIDNASRYTKPGdEIAITCDENE 505
Cdd:TIGR02956 530 LSISPRPFDLNALLDDVHHLMVSRAQLKGIQLRLNIPEQlpNWWQGDGPRIRQVLINLVGNAIKFTDRG-SVVLRVSLND 608
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446910524 506 SEDILY-IKDTGTGIAPEHLQQVFDRFYKVDAARTRGkqGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE 583
Cdd:TIGR02956 609 DSSLLFeVEDTGCGIAEEEQATLFDAFTQADGRRRSG--GTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLTR 685
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-580 |
4.36e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 108.32 E-value: 4.36e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 472 DMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFI 551
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 446910524 552 CKMIIEEHGGSIDVK-SELGkGTTFIIKLP 580
Cdd:cd16946 81 CHNIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
258-581 |
7.46e-28 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 115.72 E-value: 7.46e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 258 RDSLINSMVEGVLGINESRQIILSNKMANDIMDnidedaKDFLLRQIEDTFKS-KQTEMRDLEMNARFFVVTTSYIDKIE 336
Cdd:COG3290 86 REAVLESIREGVIAVDRDGRITLINDAARRLLG------LDAIGRPIDEVLAEvLETGERDEEILLNGRVLVVNRVPIRD 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 337 QGGKSGVVVTIRDMTN----EHNLDQMKK--DFIANVSHELRTPISLLQGYTESivdgivtepDEIKESLAIVLDESKRL 410
Cdd:COG3290 160 DGRVVGAVATFRDRTElerlEEELEGVKElaEALRAQRHDFRNHLHTISGLLQL---------GEYDEALEYIDEISEEL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 411 NRLVNELLnvarmdaeglsVNKEVQPIAALLdkmkIKYRQQADDLGLNMTFNyCKKRVWNYDMDRMD--QVLTNLIDNAS 488
Cdd:COG3290 231 QELIDSLL-----------SRIGNPVLAALL----LGKAARARERGIDLTID-IDSDLPDLPLSDTDlvTILGNLLDNAI 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 489 RYTKPGDE----IAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYkvdaaRTRGKQGTGLGLFICKMIIEEHGGSID 564
Cdd:COG3290 295 EAVEKLPEeerrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF-----STKLGEGRGLGLALVKQIVEKYGGTIE 369
|
330
....*....|....*..
gi 446910524 565 VKSELGKGTTFIIKLPK 581
Cdd:COG3290 370 VESEEGEGTVFTVRLPK 386
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-580 |
1.78e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 106.26 E-value: 1.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTKPGD--EIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDaarTRGK-QGTGLGLFIC 552
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 446910524 553 KMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
365-580 |
2.33e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 112.19 E-value: 2.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 365 ANVSHELRTPISLLQGYT----ESIVDGivTEPDEIKESLAivlDESKRLNRLVNELLNV---ARMDAEGLSVNKEVQPI 437
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAkyfaERAPAG--GEAHQLAQVMA---KEADRLNRVVSELLELvkpTHLALQAVDLNDLINHS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 438 AALLdkmkikyRQQADDLG--LNMTFNYCKKRVwNYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDT 515
Cdd:PRK10364 317 LQLV-------SQDANSREiqLRFTANDTLPEI-QADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDS 388
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446910524 516 GTGIAPEHLQQVFDRFYkvdaarTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:PRK10364 389 GKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
357-580 |
5.17e-26 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 113.21 E-value: 5.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 357 DQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTE-------PDEIKESlaiVLDESkrlnRLVNELLNVARMDAEGLS 429
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEgspharqASEIRQQ---VLNTT----RLVNNLLDMARIQSGGFN 733
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 430 VNKEVQPI-----AAL--LDKMkIKYRQQADDLGLNMTFNYCkkrvwnyDMDRMDQVLTNLIDNASRYTKPGDEIAI--T 500
Cdd:PRK10490 734 LRKEWLTLeevvgSALqmLEPG-LSGHPINLSLPEPLTLIHV-------DGPLFERVLINLLENAVKYAGAQAEIGIdaH 805
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 501 CDENESEdiLYIKDTGTGIAPEHLQQVFDRFykvdaarTRGKQ-----GTGLGLFICKMIIEEHGGSIDVKSELGKGTTF 575
Cdd:PRK10490 806 VEGERLQ--LDVWDNGPGIPPGQEQLIFDKF-------ARGNKesaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACF 876
|
....*
gi 446910524 576 IIKLP 580
Cdd:PRK10490 877 RVTLP 881
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
480-580 |
1.21e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 101.51 E-value: 1.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 480 LTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEH 559
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 446910524 560 GGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
365-580 |
2.04e-24 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 105.72 E-value: 2.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 365 ANVSHELRTPISLLQGYTEsIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDA---EGLSVNKEVQPIAALL 441
Cdd:COG5806 206 ASIAHEVRNPLTVVRGFIQ-LLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPeklEKIDVSEELEHVIDVL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 442 DKMKIKYR---QQADDLGLNMTfnyckkrvwnYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTG 518
Cdd:COG5806 285 SPYANMNNveiQTELEPGLYIE----------GDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVG 354
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446910524 519 IAPEHLQQVFDRFYKvdaarTRGKqGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:COG5806 355 MTKEQLERLGEPYFS-----TKEK-GTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
345-580 |
5.74e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 104.69 E-value: 5.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 345 VTIRDMTNehNLDQM---KKDFIANVSHELRTPISLLQgYTESIVDGIvTEPdeikESLAIVLDESKrLNRLVNELLNVA 421
Cdd:PRK10604 196 VAFNQMAD--NINALiasKKQLIDGIAHELRTPLVRLR-YRLEMSDNL-SAA----ESQALNRDIGQ-LEALIEELLTYA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 422 RMDAEGLSVNkeVQPI------AALLDKMKIKYRQQADDLGLNMTFNYckkrvWNYDMDRMDQVLTNLIDNASRYTkpGD 495
Cdd:PRK10604 267 RLDRPQNELH--LSEPdlpawlSTHLADIQAVTPEKTVRLDTPHQGDY-----GALDMRLMERVLDNLLNNALRYA--HS 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 496 EIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDV-KSELGkGTT 574
Cdd:PRK10604 338 RVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCdESELG-GAR 416
|
....*.
gi 446910524 575 FIIKLP 580
Cdd:PRK10604 417 FSFSWP 422
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-580 |
8.46e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 95.95 E-value: 8.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKvdaarTRG-KQGTGLGLFICKM 554
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPvGEGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 446910524 555 IIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
352-580 |
1.27e-23 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 103.11 E-value: 1.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 352 NEHNLDQMK-KD-FIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVL-DESKR----LNRLVNELLNVARMD 424
Cdd:PRK09303 141 NETLLEQLKfKDrVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQLqDQARRqleeIERLITDLLEVGRTR 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 425 AEGLSVN-KEVQ--PIAA-----LLDKMKIKYRQ-QAD---DLGLnmtfnyckkrVWNyDMDRMDQVLTNLIDNASRYTK 492
Cdd:PRK09303 221 WEALRFNpQKLDlgSLCQevileLEKRWLAKSLEiQTDipsDLPS----------VYA-DQERIRQVLLNLLDNAIKYTP 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 493 PGDEIAITcdenesedILY---------IKDTGTGIAPEHLQQVFDRFYKVDaaRTRGKQGTGLGLFICKMIIEEHGGSI 563
Cdd:PRK09303 290 EGGTITLS--------MLHrttqkvqvsICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQI 359
|
250
....*....|....*..
gi 446910524 564 DVKSELGKGTTFIIKLP 580
Cdd:PRK09303 360 WVDSEPGQGSCFHFTLP 376
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
182-580 |
2.21e-22 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 102.03 E-value: 2.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 182 VIFLTVTTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMsteieehvdaLSTSKNIRDSL 261
Cdd:PRK15347 304 LILVLLTSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKAYNQL----------LDTLNEQYDTL 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 262 INSMVEGVLGINESRQiilsnkmandimdnidedakdfllrqiedtfkskQTEmrdlEMNARffvvttsyidkieqggKS 341
Cdd:PRK15347 374 ENKVAERTQALAEAKQ----------------------------------RAE----QANKR----------------KS 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 342 gvvvtirdmtnEHnldqmkkdfIANVSHELRTP-------ISLLQGytesivdgivTEPDEIKESLA-IVLDESKRLNRL 413
Cdd:PRK15347 400 -----------EH---------LTTISHEIRTPlngvlgaLELLQN----------TPLTAEQMDLAdTARQCTLSLLAI 449
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 414 VNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMtfnYC--KKRVWNY-DMD--RMDQVLTNLIDNAS 488
Cdd:PRK15347 450 INNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTL---RTfvGAHVPLYlHLDslRLRQILVNLLGNAV 526
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 489 RYTKPGdEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAArtrgKQGTGLGLFICKMIIEEHGGSIDVKSE 568
Cdd:PRK15347 527 KFTETG-GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTLFST 601
|
410
....*....|..
gi 446910524 569 LGKGTTFIIKLP 580
Cdd:PRK15347 602 PGVGSCFSLVLP 613
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
364-580 |
2.97e-22 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 100.01 E-value: 2.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 364 IANVSHELRTPISLLQGYT--------ESivdgivtepdeiKEsLAIVLDESKRLNRLVNELLNVARMDAEgLSVNKEVQ 435
Cdd:PRK09470 247 LSDISHELRTPLTRLQLATallrrrqgES------------KE-LERIETEAQRLDSMINDLLVLSRNQQK-NHLERETF 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 436 PIAALLDKMKIKYRQQADDLGLNMTFNYCKKRvW--NYDMDRMDQVLTNLIDNASRYTKpgDEIAITCDENESEDILYIK 513
Cdd:PRK09470 313 KANSLWSEVLEDAKFEAEQMGKSLTVSAPPGP-WpiNGNPNALASALENIVRNALRYSH--TKIEVAFSVDKDGLTITVD 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446910524 514 DTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDV-KSELGkGTTFIIKLP 580
Cdd:PRK09470 390 DDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLP 456
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
355-580 |
5.44e-22 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 100.96 E-value: 5.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 355 NLDQMKKDFIANVSHELRTPISLLQGYTEsIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEV 434
Cdd:PRK09959 707 NATVAKSQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQW 785
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 435 QPIAALLDKMKIKYRQQA--DDLGLNMTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYTKPGdEIAITC-----DENESE 507
Cdd:PRK09959 786 VDIPTLVQNTCHSFGAIAasKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEG-AVKITTslghiDDNHAV 864
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446910524 508 DILYIKDTGTGIAPEHLQQVFDRFYKVDAARTrgKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:PRK09959 865 IKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQ--QTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
355-580 |
1.93e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 98.82 E-value: 1.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 355 NLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTepDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEV 434
Cdd:PRK11466 439 KASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPAL--NAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVSD 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 435 QPIA--ALLDKMK--IKYRQQADDLGLNMTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYTKPGdEIAITCDENESEDIL 510
Cdd:PRK11466 517 EPFEprPLLESTLqlMSGRVKGRPIRLATDIADDLPTALMGDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLV 595
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 511 YIKDTGTGIAPEHLQQVFDRFYKVDAARTrgkqGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKRG----GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| HisK_sensor |
pfam18698 |
Histidine kinase sensor domain; The Bacillus subtilis ResD-ResE two-component (TC) regulatory ... |
39-164 |
4.04e-21 |
|
Histidine kinase sensor domain; The Bacillus subtilis ResD-ResE two-component (TC) regulatory system activates genes involved in nitrate respiration in response to oxygen limitation or nitric oxide (NO). The sensor kinase ResE activates the response regulator ResD through phosphorylation, which then binds to the regulatory region of genes involved in anaerobiosis to activate their transcription. In other words, ResE is involved in sensing signals related to the redox state of the cells. ResE is composed of an N-terminal signal input domain and a C-terminal catalytic domain. The N-terminal domain contains two transmembrane subdomains and a large extra-cytoplasmic loop. Mutational analysis indicate that cytoplasmic ResE lacking the transmembrane segments and the extra-cytoplasmic loop retains the ability to sense oxygen limitation and NO, which leads to transcriptional activation of ResDE-dependent genes. Having said that, it is also proposed that the extra-cytoplasmic region may serve as a second signal-sensing subdomain. This suggests that the extracytoplasmic region could contribute to amplification of ResE activity leading to the robust activation of genes required for anaerobic metabolism in B. subtilis. This entry represents the extracytoplasmic subdomain. Family members also include SrrB found in S. aureus that is similar to ResE of B. subtilis.
Pssm-ID: 436672 Cd Length: 126 Bit Score: 89.16 E-value: 4.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 39 FTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGGLMII-NNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFD 117
Cdd:pfam18698 1 HIQEAENELTQTANKISSIVEEHEDEELALEIAWELLDDSTGVVIVkDDGEVWYSPESEELKKLPLSFILNDPELSKVFE 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446910524 118 KGKSVTRNVTI--KEKGSSQTYILLGYPTKAQKNSHskySGVFIYKDLK 164
Cdd:pfam18698 81 GGKTVKKEMSLsnNEENRYENYLIVGVPLKLSNGEN---GAVFIYQSLE 126
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
360-582 |
3.50e-20 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 94.62 E-value: 3.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 360 KKDFIANVSHELRTPISLLQGYTESIVDgivTEPDEIKES-LAIVLDESKRLNRLVNELLNVARMDAEGLSV-NK----- 432
Cdd:PRK11091 283 KTTFISTISHELRTPLNGIVGLSRILLD---TELTAEQRKyLKTIHVSAITLGNIFNDIIDMDKMERRKLQLdNQpidft 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 433 ----EVQPIAALLDKMKikyrqqadDLGLNMTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYTKPGdEIAITCDENESED 508
Cdd:PRK11091 360 dflaDLENLSGLQAEQK--------GLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQG-GVTVRVRYEEGDM 430
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446910524 509 ILY-IKDTGTGIAPEHLQQVFDRFYKV-DAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKP 582
Cdd:PRK11091 431 LTFeVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAP 506
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
358-580 |
6.14e-20 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 94.27 E-value: 6.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 358 QMKKDFIANVSHELRTPI-------SLLQgyTESIvdgivtePDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSV 430
Cdd:PRK10841 445 QSKSMFLATVSHELRTPLygiignlDLLQ--TKEL-------PKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKI 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 431 N-KEVQP------IAALLDKMKIKYRqqaddLGLnmtfnYC--KKRVWNY---DMDRMDQVLTNLIDNASRYTKPGDEI- 497
Cdd:PRK10841 516 EpREFSPrevinhITANYLPLVVKKR-----LGL-----YCfiEPDVPVAlngDPMRLQQVISNLLSNAIKFTDTGCIVl 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 498 AITCDEneseDILY--IKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTF 575
Cdd:PRK10841 586 HVRVDG----DYLSfrVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQF 661
|
....*
gi 446910524 576 IIKLP 580
Cdd:PRK10841 662 TIRIP 666
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-579 |
6.30e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 85.64 E-value: 6.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 470 NYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGL 549
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGL 94
|
90 100 110
....*....|....*....|....*....|
gi 446910524 550 FICKMIIEEHGGSIDVKSELGKGTTFIIKL 579
Cdd:cd16947 95 TITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-580 |
6.53e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 85.03 E-value: 6.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 479 VLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARtRGKQGTGLGLFICKMIIEE 558
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLCDK 87
|
90 100
....*....|....*....|..
gi 446910524 559 HGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16948 88 LGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
472-580 |
6.87e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 85.24 E-value: 6.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 472 DMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILY-IKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLF 550
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLtVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 446910524 551 ICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
356-582 |
8.67e-20 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 92.60 E-value: 8.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 356 LDQMK-----KDFIANV----SHELRTPISLLQGYTESIVDGIvtePDEIKESLAI-VLDESKRLNRLVNELLNVARM-- 423
Cdd:PRK11100 243 LESMRvklegKAYVEQYvqtlTHELKSPLAAIRGAAELLQEDP---PPEDRARFTGnILTQSARLQQLIDRLLELARLeq 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 424 -----DAEGLSVNKEVQPI----AALLDKMKIKYRQQADDLGLNmtfnyckkrvWNYDMDRmdQVLTNLIDNASRYTKPG 494
Cdd:PRK11100 320 rqeleVLEPVALAALLEELvearEAQAAAKGITLRLRPDDARVL----------GDPFLLR--QALGNLLDNAIDFSPEG 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 495 DEIAITCDENESEDILYIKDTGTGIaPEH-LQQVFDRFYKVdaAR-TRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKG 572
Cdd:PRK11100 388 GTITLSAEVDGEQVALSVEDQGPGI-PDYaLPRIFERFYSL--PRpANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGG 464
|
250
....*....|
gi 446910524 573 TTFIIKLPKP 582
Cdd:PRK11100 465 VLATLTLPRH 474
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-579 |
1.22e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 84.38 E-value: 1.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNASRYTKPGDEIAITCdENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTrgkQGTGLGLFICKMIIE 557
Cdd:cd16940 16 LLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNY---GGSGLGLSIVKRIVE 91
|
90 100
....*....|....*....|..
gi 446910524 558 EHGGSIDVKSELGKGTTFIIKL 579
Cdd:cd16940 92 LHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-581 |
3.03e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 83.14 E-value: 3.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNASRYTKPGDEIAITCDENESedILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIE 557
Cdd:cd16949 3 RALENVLRNALRYSPSKILLDISQDGDQW--TITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 446910524 558 EHGGSIDVKSELGKGTTFIIKLPK 581
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-580 |
3.34e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 82.83 E-value: 3.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNA----SRYTKPGDEIAITCDENES-EDILYIKDTGTGIAPEHLQQVFDRFYkvdaarTRGKQGTGLGLFIC 552
Cdd:cd16920 3 QVLINLVRNGieamSEGGCERRELTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 446910524 553 KMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
360-580 |
4.61e-19 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 91.45 E-value: 4.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 360 KKDFIANVSHELRTPISLLQGYT---------ESIVDGIVTepdeIKES----LAI---VLDESKrlnrlvnelLNVARM 423
Cdd:PRK11107 293 KSEFLANMSHELRTPLNGVIGFTrqtlktpltPTQRDYLQT----IERSannlLAIindILDFSK---------LEAGKL 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 424 DAEGLSVnkevqPIAALLDKMKIKYRQQADDLGLNMTFNyCKKRVWNY---DMDRMDQVLTNLIDNASRYTKPGD-EIAI 499
Cdd:PRK11107 360 VLENIPF-----SLRETLDEVVTLLAHSAHEKGLELTLN-IDPDVPDNvigDPLRLQQIITNLVGNAIKFTESGNiDILV 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 500 TCDENESEDILY---IKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFI 576
Cdd:PRK11107 434 ELRALSNTKVQLevqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFW 513
|
....
gi 446910524 577 IKLP 580
Cdd:PRK11107 514 FHLP 517
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
363-560 |
3.43e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 87.40 E-value: 3.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 363 FIANVSHELRTPISLLQGYTEsiVDGIVTEPDEIKESLAIVLDES-KRLNRLVNELLNVARMDAegLSVNKEVQPIA--A 439
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTE--VAQLSDDDPQARKKALLQLHAGiDRATRLVDQLLTLSRLDS--LDNLQDVAEIPleD 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 440 LLDK--MKIKYRQQADDLGLNMTFNyckkrvwNYDMDRMDQVL------TNLIDNASRYTKPGDEIAITCDENEsediLY 511
Cdd:PRK10337 316 LLQSavMDIYHTAQQAGIDVRLTLN-------AHPVIRTGQPLllsllvRNLLDNAIRYSPQGSVVDVTLNARN----FT 384
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 446910524 512 IKDTGTGIAPEHLQQVFDRFYkvdaaRTRG--KQGTGLGLFICKMIIEEHG 560
Cdd:PRK10337 385 VRDNGPGVTPEALARIGERFY-----RPPGqeATGSGLGLSIVRRIAKLHG 430
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-580 |
5.45e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 79.35 E-value: 5.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGkqGTGLGLFICKMI 555
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTE--GAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 446910524 556 IEEHGGSIDVKSElGKGTTFIIKLP 580
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-580 |
9.38e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 78.64 E-value: 9.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTkpGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGkqGTGLGLFICKMI 555
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS--GTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 446910524 556 IEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-580 |
1.05e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 78.48 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 479 VLTNLIDNA----SRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKvdaarTRGKQGTGLGLFICKM 554
Cdd:cd16915 4 IVGNLIDNAldalAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 446910524 555 IIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
347-583 |
1.61e-17 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 85.35 E-value: 1.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 347 IRDMTNEHNldQMKKD----------FIANVSHELRTPISLLQGYTESIV-------DGIVTEpdeIKESLAIVldeskr 409
Cdd:PRK09467 208 VRSVTRAFN--QMAAGikqleddrtlLMAGVSHDLRTPLTRIRLATEMMSeedgylaESINKD---IEECNAII------ 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 410 lNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKmkikyRQQADDLGLNMtfnyCKKRVWnydMDR--MDQVLTNLIDNA 487
Cdd:PRK09467 277 -EQFIDYLRTGQEMPMEMADLNALLGEVIAAESG-----YEREIETALQP----GPIEVP---MNPiaIKRALANLVVNA 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 488 SRYTKpgDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARtrGKQGTGLGLFICKMIIEEHGGSIDV-K 566
Cdd:PRK09467 344 ARYGN--GWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSAR--GSSGTGLGLAIVKRIVDQHNGKVELgN 419
|
250
....*....|....*..
gi 446910524 567 SELGkGTTFIIKLPKPE 583
Cdd:PRK09467 420 SEEG-GLSARAWLPLTT 435
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-580 |
2.90e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 74.77 E-value: 2.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTKPGDEIAITCDENESedILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMI 555
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRL--TLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*.
gi 446910524 556 IEEHGGSIDV-KSELGkGTTFIIKLP 580
Cdd:cd16939 79 ALWHGGHVECdDSELG-GACFRLTWP 103
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
258-580 |
5.87e-16 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 80.73 E-value: 5.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 258 RDSLINSMVEGVLGINESRQIILSNKMANDIM--------DNIDEDAKDFLLR-QIEDTFKSKQTEM-RDLEMNARFFVV 327
Cdd:PRK11086 223 RQAMLQSIKEGVIAVDDRGEVTLINDEAKRLFnykkgledDPLGTDVESWMPVsRLKEVLRTGTPRRdEEININGRLLLT 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 328 TTSYIdkIEQGGKSGVVVTIRDMTNehnldqmkkdfianVSHelrtpisLLQGytesiVDGIVTEPD-------EIKESL 400
Cdd:PRK11086 303 NTVPV--RVNGEIIGAIATFRDKTE--------------VRQ-------LAQR-----LDGMVNYADalraqshEFMNKL 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 401 AIVLD--ESKRLNRLVNELLNVA-RMDAEGLSVNKEVQ-PIAA--LLDKMkikyrQQADDLGLNMTFNyCKKRVWNYDMD 474
Cdd:PRK11086 355 HVILGllHLKSYDQLEDYILKTAnNYQEEIGSLLGKIKsPVIAgfLLGKI-----SRARELGITLIIS-EDSQLPDSGDE 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 475 RMDQVLT----NLIDNA--SRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKvdaarTRGKqGTGLG 548
Cdd:PRK11086 429 DQVHELItilgNLIENAleAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYS-----TKGS-NRGVG 502
|
330 340 350
....*....|....*....|....*....|..
gi 446910524 549 LFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:PRK11086 503 LYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-580 |
6.60e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 73.76 E-value: 6.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNASRYTKPGD-EIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMII 556
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82
|
90 100
....*....|....*....|....*...
gi 446910524 557 EEHGGSIDVKS----ELGKGTTFIIKLP 580
Cdd:cd16953 83 EAHGGISVAENhnqpGQVIGARFTVQLP 110
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
357-422 |
9.94e-16 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 71.86 E-value: 9.94e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446910524 357 DQMKKDFIANVSHELRTPISLLQGYTESIVDGIvTEPDEIKESLAIVLDESKRLNRLVNELLNVAR 422
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEEL-LDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
363-580 |
1.16e-15 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 80.56 E-value: 1.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 363 FIANVSHELRTPISLLQGYTESIvdGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLD 442
Cdd:TIGR03785 488 MSSRLSHELRTPVAVVRSSLENL--ELQALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLS 565
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 443 KMKIKYRQQadDLGLNMTFNYCKK-RVWNYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIaP 521
Cdd:TIGR03785 566 GCMQGYQMT--YPPQRFELNIPETpLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPL-P 642
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446910524 522 EHL-QQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSEL-GKGTTFIIKLP 580
Cdd:TIGR03785 643 EDMgEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISLP 703
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
359-426 |
3.02e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 70.32 E-value: 3.02e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446910524 359 MKKDFIANVSHELRTPISLLQGYTESIVDGivTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAE 426
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDE--KLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
364-570 |
3.58e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 78.14 E-value: 3.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 364 IANVSHELRTPISLLQGYTESIVDGIVTEpdeIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDK 443
Cdd:PRK10815 270 LTDLTHSLKTPLAVLQSTLRSLRSGKQMS---VEQAEPIMLEQISRISQQIGYYLHRASMRSEHNLLSRELHSVAPLLDN 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 444 M-----KIKYRQqaddlGLNMTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESedILYIKDTGTG 518
Cdd:PRK10815 347 LtsalnKVYQRK-----GVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHL--HIVVEDDGPG 419
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 446910524 519 IAPEHLQQVFDRFYKVDAARTrgkqGTGLGLFICKMIIEEHGGSIDV-KSELG 570
Cdd:PRK10815 420 IPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAgDSPLG 468
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-442 |
5.17e-15 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 78.23 E-value: 5.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 1 MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG 80
Cdd:COG2770 38 ALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 81 LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIY 160
Cdd:COG2770 118 LALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 161 KDLKSIEDTNNAITIITIITAVIFLTVTTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQM 240
Cdd:COG2770 198 LLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRM 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 241 STEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKDFLLRQIEDTFKSKQTEMRDLEM 320
Cdd:COG2770 278 ADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALA 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 321 NARFFVVTTSYIDKIEQGGKSGVVVTIRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESL 400
Cdd:COG2770 358 ALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAA 437
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 446910524 401 AIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLD 442
Cdd:COG2770 438 LELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALL 479
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
359-426 |
6.16e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 69.52 E-value: 6.16e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446910524 359 MKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDeiKESLAIVLDESKRLNRLVNELLNVARMDAE 426
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
200-244 |
6.35e-15 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 68.63 E-value: 6.35e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446910524 200 TKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEI 244
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
182-433 |
1.14e-14 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 76.46 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 182 VIFLTVTTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTS-----KN 256
Cdd:COG3850 125 LLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEeeleaEL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 257 IRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKDFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIE 336
Cdd:COG3850 205 ELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELE 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 337 QGGKSGVVVTIRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNE 416
Cdd:COG3850 285 LLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAA 364
|
250
....*....|....*..
gi 446910524 417 LLNVARMDAEGLSVNKE 433
Cdd:COG3850 365 AAAAAGLARALAQAGAD 381
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-579 |
1.40e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 69.79 E-value: 1.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNA--SRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYkvdAARTRGKqGTGLGLFICKMI 555
Cdd:cd16976 3 QVLMNLLQNAldAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVGK-GTGLGLSISYGI 78
|
90 100
....*....|....*....|....
gi 446910524 556 IEEHGGSIDVKSELGKGTTFIIKL 579
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HAMP |
pfam00672 |
HAMP domain; |
194-246 |
3.32e-14 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 66.88 E-value: 3.32e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 446910524 194 FLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEE 246
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
198-249 |
3.33e-14 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 66.89 E-value: 3.33e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446910524 198 RITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVD 249
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-580 |
2.79e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 66.41 E-value: 2.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 472 DMDRMDQVLTNLIDNAS-----RYTKPGdEIAITCDENESEDI-LYIKDTGTGIAPEHLQQVFDRFykvdaARTRGKqGT 545
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVG-EVRIRVEADQDGRIvLIVCDNGKGFPREMRHRATEPY-----VTTRPK-GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 446910524 546 GLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-566 |
5.96e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 65.17 E-value: 5.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTrGKQGTGLGLFICKMIIE 557
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHS-GQKSTGLGLAFVQEVAQ 85
|
....*....
gi 446910524 558 EHGGSIDVK 566
Cdd:cd16945 86 LHGGRITLR 94
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
478-580 |
7.16e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 71.63 E-value: 7.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNASRYTKPGDEIAITCD--ENESEDIL---------YI----KDTGTGIAPEHLQQVFDRFYKvdaarTRGk 542
Cdd:PRK13837 563 QVLMNLCSNAAQAMDGAGRVDISLSraKLRAPKVLshgvlppgrYVllrvSDTGAGIDEAVLPHIFEPFFT-----TRA- 636
|
90 100 110
....*....|....*....|....*....|....*...
gi 446910524 543 QGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:PRK13837 637 GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-578 |
7.58e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 64.79 E-value: 7.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 472 DMDRMDQVLTNLIDNASRYTKPGDEIAIT-CDENEsedILY--IKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQgTGLG 548
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISiYDEEE---YLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRSGGH-YGMG 76
|
90 100 110
....*....|....*....|....*....|
gi 446910524 549 LFICKMIIEEHGGSIDVKSELGKGTTFIIK 578
Cdd:cd16975 77 LYIAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
432-579 |
1.15e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 62.26 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 432 KEVQPIAALLDKMkikYRqqadDLGLNMTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYtkpGDE-IAITCDENESEDIL 510
Cdd:cd16954 1 PLLDSLCSALNKV---YQ----RKGVSISLDISPELRFPGERNDLMELLGNLLDNACKW---CLEfVEVTARQTDGGLHL 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 511 YIKDTGTGIAPEHLQQVFDRFYKVDAARtrgkQGTGLGLFICKMIIEEHGGSIDV-KSELGkGTTFIIKL 579
Cdd:cd16954 71 IVDDDGPGVPESQRSKIFQRGQRLDEQR----PGQGLGLAIAKEIVEQYGGELSLsDSPLG-GARFEVVF 135
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
478-580 |
6.03e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 59.70 E-value: 6.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 478 QVLTNLIDNASRYTKPGDEIAITcdenesedilyIKDTGTGIAPEHLQQVFDRFYKvdaarTRG-KQGTGLGLFICKMII 556
Cdd:cd16919 29 QRVDADYALNYRDLIPGNYVCLE-----------VSDTGSGMPAEVLRRAFEPFFT-----TKEvGKGTGLGLSMVYGFV 92
|
90 100
....*....|....*....|....
gi 446910524 557 EEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16919 93 KQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
352-580 |
1.15e-10 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 63.18 E-value: 1.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 352 NEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIvtePD-EIKESLAIVLDESKRLNRLVNELLNVARmdaEGLsv 430
Cdd:PRK11073 122 LQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKAL---PDpALTEYTKVIIEQADRLRNLVDRLLGPQR---PGT-- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 431 nKEVQPIAALLDKMkikyRQQAD-DLGLNMTFnyckkrVWNYD---------MDRMDQVLTNLIDNASR-YTKPGDEIAI 499
Cdd:PRK11073 194 -HVTESIHKVAERV----VQLVSlELPDNVRL------IRDYDpslpelahdPDQIEQVLLNIVRNALQaLGPEGGTITL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 500 TCDENESEDI----------LYIKDTGTGIaPEHLQQVFdrFYKVDAARtrgKQGTGLGLFICKMIIEEHGGSIDVKSEL 569
Cdd:PRK11073 263 RTRTAFQLTLhgeryrlaarIDIEDNGPGI-PPHLQDTL--FYPMVSGR---EGGTGLGLSIARNLIDQHSGKIEFTSWP 336
|
250
....*....|.
gi 446910524 570 GKgTTFIIKLP 580
Cdd:PRK11073 337 GH-TEFSVYLP 346
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
1-254 |
1.20e-10 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 64.27 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 1 MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGG 80
Cdd:COG0840 2 LILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 81 LMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTI------KEKGSSQTYILLGYPTKAQKNSHSKY 154
Cdd:COG0840 82 LALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIallalaALLALAALALALLALALLAAAAAAAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 155 SGVFIYKDLKSIEDTNNAITIITIITAVIFLTVTTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLS 234
Cdd:COG0840 162 ALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLA 241
|
250 260
....*....|....*....|
gi 446910524 235 QAFNQMSTEIEEHVDALSTS 254
Cdd:COG0840 242 DAFNRMIENLRELVGQVRES 261
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
354-561 |
3.05e-10 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 61.91 E-value: 3.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 354 HNLDQmKKDFIANVSHELRTPISLLQGYTEsivdgiVTEPDEIKESLAIVldesKRLNRL---VNELLNVARMD---AEG 427
Cdd:PRK10755 132 STLDQ-ERLFTADVAHELRTPLAGIRLHLE------LLEKQHHIDVAPLI----ARLDQMmhtVEQLLQLARAGqsfSSG 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 428 ----LSVNKEV-QPIAALLDKMkIKYRQQADDLGLNMTFNYCKKrvwNYDMDRMdqVLTNLIDNASRYTKPGDEIAITCD 502
Cdd:PRK10755 201 hyqtVKLLEDViLPSQDELSEM-LEQRQQTLLLPESAADITVQG---DATLLRL--LLRNLVENAHRYSPEGSTITIKLS 274
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446910524 503 ENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDaarTRGKqGTGLGLFICKMIIEEHGG 561
Cdd:PRK10755 275 QEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD---SRYG-GIGLGLSIVSRITQLHHG 329
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-580 |
1.25e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 55.87 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 476 MDQVLTNLIDNASRYTKPGD-EIAITCDENESEDI----------LYIKDTGTGIAPEHLQQVFDRFYkvdaarTRGKQG 544
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgEIILRTRTQRQVTLghprhrlalrVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 446910524 545 TGLGLFICKMIIEEHGGSIDVKSELGKgTTFIIKLP 580
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
367-580 |
1.52e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 60.86 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 367 VSHELRTPISLLQGYTESIVDGIVTEPDE-IKESLAIVLDESKRLNRLVNELLNVARMDAEGL-SVN-KEVQPIAALLDK 443
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALEQENYAqLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLqPVDlRQVIEQAWELVE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 444 MKIKyRQQAddlglnmTFNYCKKRVWNYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPeh 523
Cdd:COG4192 520 SRAK-PQQI-------TLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL-- 589
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446910524 524 LQQVFDRFYkvdaarTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:COG4192 590 VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
358-580 |
1.06e-08 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 58.41 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 358 QMKKDFIANVSHELRTPISLLQGYTESIVDgiVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPI 437
Cdd:PRK10618 448 QARKAFLQNIGDELKQPLQSLAQLAAQLRQ--TSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSL 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 438 AALLD--------KMKIKyrqqaddlGLNMTFNYCKK--RVWNYDMDRMDQVLTNLIDNASRYTKPGdEIAITCD-ENES 506
Cdd:PRK10618 526 QDLIDevlpevlpAIKRK--------GLQLLIHNHLKaeQLRIGDRDALRKILLLLLNYAITTTAYG-KITLEVDqDESS 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 507 EDILYIK--DTGTGIAPEHL---------QQVFDRFYkvdaartrgkQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTF 575
Cdd:PRK10618 597 PDRLTIRilDTGAGVSIKELdnlhfpflnQTQGDRYG----------KASGLTFFLCNQLCRKLGGHLTIKSREGLGTRY 666
|
....*
gi 446910524 576 IIKLP 580
Cdd:PRK10618 667 SIHLK 671
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
157-249 |
1.99e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 56.95 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 157 VFIYKDLKSIEDTNNAITIITIITAVIFLTVTTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPsVTTKDEIGQLSQA 236
Cdd:COG2972 139 LVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLE-VSGNDEIGILARS 217
|
90
....*....|...
gi 446910524 237 FNQMSTEIEEHVD 249
Cdd:COG2972 218 FNEMVERIKELIE 230
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
377-580 |
8.65e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 51.60 E-value: 8.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 377 LLQ---GYTESI---VDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVAR---MDAEGLSVN---KEVQPIA--ALLD 442
Cdd:PRK13557 177 LLQvmsGYLDVIqaaLSHPDADRGRMARSVENIRAAAERAATLTQQLLAFARkqrLEGRVLNLNglvSGMGELAerTLGD 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 443 KMKIKYRQQADdlglnmtfnyckkrVWNYDMDR--MDQVLTNLIDNAsRYTKPGDE--------IAITCDENESEDIL-- 510
Cdd:PRK13557 257 AVTIETDLAPD--------------LWNCRIDPtqAEVALLNVLINA-RDAMPEGGrvtirtrnVEIEDEDLAMYHGLpp 321
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446910524 511 --Y----IKDTGTGIAPEHLQQVFDRFYKvdaarTRGK-QGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:PRK13557 322 grYvsiaVTDTGSGMPPEILARVMDPFFT-----TKEEgKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
544-580 |
2.60e-06 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 50.18 E-value: 2.60e-06
10 20 30
....*....|....*....|....*....|....*..
gi 446910524 544 GTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
185-251 |
3.68e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 49.67 E-value: 3.68e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446910524 185 LTVTTVFafFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDAL 251
Cdd:PRK10600 137 LLVFTII--WLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAELAESYAVL 201
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
544-580 |
8.53e-06 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 46.42 E-value: 8.53e-06
10 20 30
....*....|....*....|....*....|....*..
gi 446910524 544 GTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP 580
Cdd:cd16916 142 GRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
497-580 |
1.58e-05 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 45.41 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 497 IAITCDENESEDILYIKDTGTGIAPEHLQQVFdrFYKVDAARTRGKQ---------------GTGLGLFICKMIIEEHGG 561
Cdd:cd16929 73 IKVTVAKGDEDLTIKISDRGGGIPREDLARLF--SYMYSTAPQPSLDdfsdlisgtqpsplaGFGYGLPMSRLYAEYFGG 150
|
90
....*....|....*....
gi 446910524 562 SIDVKSELGKGTTFIIKLP 580
Cdd:cd16929 151 DLDLQSMEGYGTDVYIYLK 169
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
366-583 |
6.61e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 44.61 E-value: 6.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 366 NVSHELrtpiSLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVAR---MDAEGLsvnkeVQPIAALLD 442
Cdd:COG4585 64 GVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGLRppaLDDLGL-----AAALEELAE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 443 KMkikyrqqADDLGLNMTFNYckkrvwNYDMDRMDQ-VLTNL-------IDNASRYTKpGDEIAITCDENESEDILYIKD 514
Cdd:COG4585 135 RL-------LRAAGIRVELDV------DGDPDRLPPeVELALyrivqeaLTNALKHAG-ATRVTVTLEVDDGELTLTVRD 200
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446910524 515 TGTGIAPEHLQqvfdrfykvdaartrgkqGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE 583
Cdd:COG4585 201 DGVGFDPEAAP------------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
413-583 |
7.15e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.67 E-value: 7.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 413 LVNELL----NVARMDAEGLsVNKEVQPIAALLDKMKIKYRQQADDLGLNMtfnyckkrvwnydmdrmDQ------VLTN 482
Cdd:COG3920 345 LVHELLyqseDWEGVDLRDY-LRELLEPLRDSYGGRGIRIELDGPDVELPA-----------------DAavplglILNE 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 483 LIDNASRYTKPGDE---IAITCDENESEDILYIKDTGTGIAPEhlqqvfdrfykVDAARTRGkqgtgLGLFICKMIIEEH 559
Cdd:COG3920 407 LVTNALKHAFLSGEggrIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARKG-----LGLRLIRALVRQL 470
|
170 180
....*....|....*....|....
gi 446910524 560 GGSIDVKSElgKGTTFIIKLPKPE 583
Cdd:COG3920 471 GGTLELDRP--EGTRVRITFPLAE 492
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-580 |
1.37e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.00 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 486 NASRYTkPGDEIAITCDENESEDILYIKDTGTGIAPEhlqqvfdrfykvdaartRGKQGTGLGLfickMIIEEH----GG 561
Cdd:cd16917 11 NALKHA-GASRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGL----LGMRERaellGG 68
|
90
....*....|....*....
gi 446910524 562 SIDVKSELGKGTTFIIKLP 580
Cdd:cd16917 69 TLTIGSRPGGGTRVTARLP 87
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
398-581 |
2.66e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 43.67 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 398 ESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYR------------QQADDLGLNMTF---N 462
Cdd:PRK15053 340 ESLRTLRHEHLNWMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFAdrqvagllfgkvQRARELGLKMVIvpgS 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 463 YCKKRVWNYDMDRMDQVLTNLIDNA---SRYTKPGDEIAITCDENESED-ILYIKDTGTGIAPEHLQQVFDRFYkvdAAR 538
Cdd:PRK15053 420 QLSQLPPGLDSTEFAAIVGNLLDNAfeaSLRSDEGNKIVELFLSDEGDDvVIEVADQGCGVPESLRDKIFEQGV---STR 496
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 446910524 539 TRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPK 581
Cdd:PRK15053 497 ADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
182-249 |
2.85e-04 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 43.69 E-value: 2.85e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446910524 182 VIFLTVttvfaFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKD-EIGQLSQAFNQMSTEI-------EEHVD 249
Cdd:PRK10935 164 LVFFTV-----RFTRRQVVAPLNQLVTASQQIEKGQFDHIPLDTTLPnELGLLAKAFNQMSSELhklyrslEASVE 234
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
259-358 |
5.49e-04 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 42.84 E-value: 5.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446910524 259 DSLINSMVEGVLGINESRQIILSNKMANDIMD---------NIDEDAKDFLLRQIEDTFKSKQTEMRDLEMNARFFVVTT 329
Cdd:COG3829 14 EAILDSLDDGIIVVDADGRITYVNRAAERILGlpreevigkNVTELIPNSPLLEVLKTGKPVTGVIQKTGGKGKTVIVTA 93
|
90 100
....*....|....*....|....*....
gi 446910524 330 SYIdkIEQGGKSGVVVTIRDMTNEHNLDQ 358
Cdd:COG3829 94 IPI--FEDGEVIGAVETFRDITELKRLER 120
|
|
| |
