|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
17-389 |
1.03e-166 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 473.63 E-value: 1.03e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 17 LGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAA 96
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 97 LSDSIWGIILGRALQGSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILAT 176
Cdd:cd17472 81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 177 TGIALTIWVVPNSSTHVLNRESgmVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEHWKVYLAT 256
Cdd:cd17472 161 VSLLILLFFVPDPPKIVQISEK--EKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 257 MLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYK 336
Cdd:cd17472 239 ILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYR 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446923700 337 GTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMK 389
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-389 |
7.75e-47 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 165.83 E-value: 7.75e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 17 LGTVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAA 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 97 LSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAIL 174
Cdd:cd17325 80 FATSYWQLLLARFLQGlaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 175 ATTGIALTIWVVPNS-STHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVA-LPGQLADAGFPAAEHWKV 252
Cdd:cd17325 160 ALLALVLALLLLPEPrPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPfLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 253 YLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAeIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESP 332
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA-LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446923700 333 AGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMK 389
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-353 |
4.53e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 155.13 E-value: 4.53e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 7 TPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLA 86
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 87 VFAAGSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGL 164
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGlgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 165 HALFWMIAILATTGIALTIWVVPNSSTHVLNREsgmvKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AG 243
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARL----RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 244 FPAAEHWKVYLATMLIAFGSVVPFIIYAEvKRKMKQVFVFCVGLIVVAeIVLWNAQTQFWQLVVGVQLFFVAFNLMEALL 323
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLAD-RFGRRRLLLIGLLLLALG-LLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
|
330 340 350
....*....|....*....|....*....|
gi 446923700 324 PSLISKESPAGYKGTAMGVYSTSQFLGVAI 353
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-385 |
2.59e-39 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 145.41 E-value: 2.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 15 WGLGTVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVI 94
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEAL-GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 95 AALSDSIWGIILGRALQ--GSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGitfaIAMVLGPIITHKLGLH---ALFW 169
Cdd:cd17474 81 CGLSDSFALLLAGRALQgiGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALG----LGIAVGPLLGGLLAAIswrYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 170 MIAILATTGIALTIWVVPNSSTHVlNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPgQLADAGFPAAEH 249
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEKA-KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP-FLLELLYGISPI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 250 WK-VYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLIS 328
Cdd:cd17474 235 IIgLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446923700 329 KESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:cd17474 315 ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-385 |
3.56e-34 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 131.39 E-value: 3.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 17 LGTVFSLRMLGMFMVLPVLTTYgMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAA 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPAL-LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 97 LSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIIT--HKLGLHALFWMIA 172
Cdd:cd06174 80 FAPSFWLLLLGRFLLGlgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 173 ILATTGIALTIWVVPNSSTHVLNR----ESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AGFPAA 247
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKneeaSSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 248 EHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMeALLPSLI 327
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL-PLSFALI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446923700 328 SKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWI-DGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-354 |
8.95e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.07 E-value: 8.95e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 17 LGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAA 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 97 LSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAIL 174
Cdd:pfam07690 81 FASSLWLLLVLRVLQGlgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 175 ATTGIALTIWVV--PNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEHWKV 252
Cdd:pfam07690 161 SLLAAVLLLLPRppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 253 YLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIV-VAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKES 331
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|...
gi 446923700 332 PAGYKGTAMGVYSTSQFLGVAIG 354
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-384 |
6.12e-30 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 119.62 E-value: 6.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGI 104
Cdd:cd17489 9 FLSFYLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 105 ILGRALQGSG--AIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALt 182
Cdd:cd17489 88 LVLRLIHGIGwgAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 183 IWVVPNssTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMS--TFVALPGQ---LADAGFpaaehwkvYLATM 257
Cdd:cd17489 167 VFLVKD--PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAisTFLPLYAAergISNAGL--------FFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 258 LIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTqFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKG 337
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS-PWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446923700 338 TAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAV 384
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
26-386 |
1.47e-29 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 118.06 E-value: 1.47e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 26 LGMFMVLPVLTTYGMAL--QGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWG 103
Cdd:cd17330 10 LGFGIVFPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 104 IILGRALQG-SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALT 182
Cdd:cd17330 90 LFLARFLDGlTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 183 IWVVPNSSthvlnresgmvkgsfskvlaepRLLKLNFGIMCLHILLMSTFvalpGQLADAGFPAAEHWKVYLATMLIAFG 262
Cdd:cd17330 170 LFFLPPLR----------------------RLLLVYFLIALAFAGLESVF----SLFLKDRFGFSPSQIGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 263 SVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA-QTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMG 341
Cdd:cd17330 224 ILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPfASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQG 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446923700 342 VYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVAS 386
Cdd:cd17330 304 IIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
15-380 |
3.62e-29 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 117.68 E-value: 3.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 15 WGLGTVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVI 94
Cdd:cd17320 2 LLLALLVALGPLAIDMYLPALPAIARDL-GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 95 AALSDSIWGIILGRALQGSGAIAAAVM--ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIA 172
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 173 ILATTGIALTIWVVPnsSTHVLNREsgmvKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEHWKV 252
Cdd:cd17320 161 LLGLLLLLLVLLFLP--ETLPEEKR----KPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 253 YLATMLIAFGSVVPFIIYAEV-------KRKMKQVFVFCVGLIVVAEIVLWNAQT----QFWQLVVGVQLFFVAFNLMEA 321
Cdd:cd17320 235 SPAQFGLLFALNAIALILGSLlngrlvrRFGPRRLLRLGLLLLLAAALVLLLAALlgglSLWPLVAPLFLIFFGFGLIFP 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446923700 322 LLPSLISKESPaGYKGTAMGVYSTSQFLGVAIGGSLGGWIdgMFDGQGVFLAGAMLAAV 380
Cdd:cd17320 315 NATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLL--PNGTALPMGLLILVLGL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-385 |
3.82e-29 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 117.27 E-value: 3.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 28 MFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILG 107
Cdd:cd17324 15 EYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 108 RALQG--SGAIAAAVMALLSDLTREQNRTKAMA--FIGVSFGITFAIamVLGPIITHKLGLHALFWMIAILATTGIALTI 183
Cdd:cd17324 94 RALAGlaHGGFWAIAAAYAADLVPPEKRGRAIGlvFSGLTLGLVLGR--PLGGLLGQLLGWRAAFLAIAVLALLAALLLW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 184 WVVPNSSTHvlNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAfGS 263
Cdd:cd17324 172 RLLPSLPPK--KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA-GV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 264 VVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGyKGTAMGVY 343
Cdd:cd17324 249 VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLY 327
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446923700 344 STSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:cd17324 328 LAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
33-380 |
3.50e-25 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 106.15 E-value: 3.50e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 33 PVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIG-RKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQ 111
Cdd:cd17490 17 PFLSPYAESL-GASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 112 GsgaIAAAV----MALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVP 187
Cdd:cd17490 96 G---IAAATwvsfTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 188 NSSTHvlNRESGMVKGSFsKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLA-DAGFPAAEHWKVYLATML--IAFGSV 264
Cdd:cd17490 173 ERREK--KPVLTELKELL-SVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAkQLGASSFQLGLLSIIYLLpnALASLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 265 VPFIIYaevkRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFF-VAFNLMEALLPSLISKESPAGYKGTAMGVY 343
Cdd:cd17490 250 SGTLFY----KKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNgFGTGILFPLLMSLSIEGVPAEQRSTAMGFF 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 446923700 344 STSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAV 380
Cdd:cd17490 326 QAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALL 362
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-359 |
1.40e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 104.56 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTYGMAL------QGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALS 98
Cdd:cd17321 2 LLAVFLAALDVTIVNVALptiardLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 99 DSIWGIILGRALQGSGA--IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILAT 176
Cdd:cd17321 82 PSLAFLIAARALQGIGAaaIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 177 TGIALTiwvvpnssthvlnresgmvkgsfskvlaePRLLKLNFGIMCLHILLMSTFVALPGQLADA-GFPAaehWKVYLA 255
Cdd:cd17321 162 VALLLA-----------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSP---LQAGLA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 256 TMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQ----FWQLVVGVQLFFVAFNLMEALLPSLISKES 331
Cdd:cd17321 210 LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGadssVWLLLPGLVLLGLGLGLFATPLTNAALSSV 289
|
330 340
....*....|....*....|....*...
gi 446923700 332 PAGYKGTAMGVYSTSQFLGVAIGGSLGG 359
Cdd:cd17321 290 PKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-389 |
2.22e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 103.80 E-value: 2.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALF 168
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGlgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 169 WMIAILATTGIALTIWVvpnssthvlnresgmvkgsfskvlaeprllkLNFGIMCLHILLMSTFVALPGQLADA-GFPAA 247
Cdd:COG2271 168 LILGLPGLLLALLRFWL-------------------------------LALAYFLVYFALYGFLTWLPTYLVEVrGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 248 EHWKVYLATMLIA-FGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVqLFFVAFNLMEALLPSL 326
Cdd:COG2271 217 QAGLLLSLPFLAGiVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLF-LAGFGLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446923700 327 ISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMK 389
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-186 |
5.56e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 102.65 E-value: 5.56e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALF 168
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGlgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*...
gi 446923700 169 WMIAILATTGIALTIWVV 186
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-385 |
5.65e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 103.04 E-value: 5.65e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALF 168
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGigGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 169 WMIAILATTGIALTIWVVPNSSTHVLNRESGMVKgSFSKVLAEPRLLKLNFgimcLHILLMSTFVALPGQLAD---AGFP 245
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR-DQLEALRDPRFWLLSL----LYFGTFGSFIGFSSWLPPylvDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 246 AAEHWKVYLATMLIAFGSVV-PFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLP 324
Cdd:COG2223 238 LSAATAGLLAALFALLGALGrPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446923700 325 SLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIdgmFDGQGVFLAGAMLAAVWLAVA 385
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL---LDATGSYTAAFLVFAVLALVA 375
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-359 |
9.21e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 102.27 E-value: 9.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTYgMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGI 104
Cdd:cd17504 9 MLVETMLSPALPTI-QREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 105 ILGRALQG-SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTI 183
Cdd:cd17504 88 IAGRALQGiGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 184 WVVPnssthvlnresgmvkgsfsKVLAEPRLLKLNFGIMCLHILLMSTFVALP--GQLADAGFPAAEHWKVYLATMLIAF 261
Cdd:cd17504 168 LIDL-------------------RLLRRRNVLLANITALLAGFGMFMVFQLLPqlLQLPTPTGFGLGITEAGLLLLPGAL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 262 GSVV--PFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTA 339
Cdd:cd17504 229 VMLIagPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIA 308
|
330 340
....*....|....*....|
gi 446923700 340 MGVYSTSQFLGVAIGGSLGG 359
Cdd:cd17504 309 TGMNTVLRTIGSAIGPAIAG 328
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-377 |
2.97e-23 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 100.76 E-value: 2.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 26 LGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGII 105
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 106 LGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIIThKLGLHALFWMIAILATTGIALTI 183
Cdd:cd17329 93 IALVLTGfgGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 184 WVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADA-GFPAAEHWKVYLATMLIAFG 262
Cdd:cd17329 172 FLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIlGLGESLLGLLLALNALLIVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 263 SVVPFIIYAEVKRKMKQVfVFCVGLIVVAEIVLWNAqTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGV 342
Cdd:cd17329 252 LQFPVARLVERFRLRKIL-MIGILLFAIGFAVLAFA-NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF 329
|
330 340 350
....*....|....*....|....*....|....*
gi 446923700 343 YSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAML 377
Cdd:cd17329 330 YALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-383 |
1.12e-22 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 99.18 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 22 SLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSI 101
Cdd:cd17473 9 TLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 102 WGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIIThKLGLHALFWM--IAILAtt 177
Cdd:cd17473 89 YALLASRALLGigVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVylLALPV-- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 178 gIALTIWVVPNSSTHVLNRESGMVKGsfSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEHWKVYLAtm 257
Cdd:cd17473 166 -LILVLLFLPEPARKSKSAASPGAAT--AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALA-- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 258 LIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQF-WQLVVGVQLFFVAFNLMEALLPSLISKESPAGYK 336
Cdd:cd17473 241 IASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGlWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446923700 337 GTAMGVYSTSQFLG-------VAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLA 383
Cdd:cd17473 321 GRAMGIVTSAFFLGqflsplvLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-269 |
3.46e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 93.34 E-value: 3.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 7 TPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLA 86
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL-GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 87 VFAAGSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGL 164
Cdd:COG0477 88 LFGLASLLCGLAPSPELLIAARALQGigAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 165 HALFWMIAILATTGIALTIWVVPNSST--HVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADA 242
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRLPESRGLllALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260
....*....|....*....|....*..
gi 446923700 243 GFPAAEHWKVYLATMLIAFGSVVPFII 269
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLAL 274
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-380 |
1.15e-20 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 92.99 E-value: 1.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 30 MVLPVLTTYgMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIG-RKPLIVGGLAVFAAGSVIAALSDSIWGIILGR 108
Cdd:cd17370 17 MARSILPLF-LVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 109 ALQ--GSGAIAAAVMALLSDLTREQNRTKAMAF------IGVSFGITFAIAMVLGpiitHKLGLHALFWMIAILATTGIA 180
Cdd:cd17370 96 ILErlGKGIRTPPRDALLADATPPSGRGKAFGLhraldtLGAVLGPLLAALLLYL----LGGNYRTIFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 181 LTIWVVPNSsthvlNRESGMVKGSFSKVLAE-PRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEHWKVYLATMLI 259
Cdd:cd17370 172 ILLFVVKEY-----PRPPKLRKKSKKTSLKKlPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 260 AFGSVVPF-IIYAEVKRKMKQVFVFCVGLIVVAEIVLwnaQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGT 338
Cdd:cd17370 247 YALAAYPAgRLSDRIGRKKLLILGYLSLALAYLGFAL---GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGT 323
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446923700 339 AMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAV 380
Cdd:cd17370 324 AYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
51-189 |
3.74e-19 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 83.47 E-value: 3.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 51 GIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLT 128
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGfgAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446923700 129 REQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNS 189
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
15-363 |
6.59e-19 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 88.21 E-value: 6.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 15 WGLGTVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVI 94
Cdd:TIGR00710 8 LLLGCLSILGPLGIDMYLPAFPEIAADL-STPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 95 AALSDSIWGIILGRALQGSGAIAAAVM--ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIA 172
Cdd:TIGR00710 87 LALSNNIETLLVLRFVQAFGASAGSVIsqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 173 ILATTGIALTIWVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEHWKV 252
Cdd:TIGR00710 167 LAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 253 YLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQ---TQFWQLVVGVQLFFVAFNLMEALLPSLISK 329
Cdd:TIGR00710 247 LFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAilgLGSWAMIIGPMMFVGIGNSMISSIAMAYAL 326
|
330 340 350
....*....|....*....|....*....|....
gi 446923700 330 ESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDG 363
Cdd:TIGR00710 327 EDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHG 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-361 |
1.29e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 84.57 E-value: 1.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 7 TPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMAL----QGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIG-----R 77
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFytdvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 78 KPLIVGGLAVFAAGSVIAALSDS-------IWGIILGRALQ-GSGAIAAAVMALLSDLTREQN-RTKAMAFIGVSFGITF 148
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDlsptgklIYALVTYLLLGlAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 149 AIAMVLGPIITHKL------GLHALFWMIAILATTGIALTIWVVPNSSTHVLNRESgmVKGSFSKVLAEPRLLKLNFGIM 222
Cdd:COG2211 161 LLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS--LKESLKALLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 223 CLHILLMSTFVALPGQLADA-GFPAAEhWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQ-T 300
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVlGLSAAL-VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpG 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446923700 301 QFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYK-------GTAMGVYSTSQFLGVAIGGSLGGWI 361
Cdd:COG2211 318 NLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
26-187 |
1.70e-17 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 83.81 E-value: 1.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 26 LGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGII 105
Cdd:PRK11102 5 LAIDMYLPALPVIAADF-GVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 106 LGRALQGSGAIAAAVM--ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTI 183
Cdd:PRK11102 84 YMRFLHGLAAAAASVVinALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163
|
....
gi 446923700 184 WVVP 187
Cdd:PRK11102 164 FFIP 167
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
48-186 |
6.50e-17 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 81.46 E-value: 6.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 48 ALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQ--GSGAIAAAVMALLS 125
Cdd:cd17502 30 SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQgiGGGGLMSLAFIIIA 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446923700 126 DLTREQNRTKAMAFigvsFGITFAIAMVLGPII----THKLGLHALFWM---IAILAtTGIALTIWVV 186
Cdd:cd17502 110 DLVPPRERGKYQGY----IGAVFGIASVAGPLIggafTDHLSWRWCFYInlpIGGLA-LALLRTILLS 172
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
23-233 |
1.35e-16 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 81.14 E-value: 1.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 23 LRMLGMFMVLPVLTTYGMALQGASEAL---IGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSD 99
Cdd:cd17388 10 LDAMGIGLIMPVLPTLLREFVGDSADAathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 100 SIWGIILGRALQG----SGAIAAAVMAllsDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHkLGLHALFWMIAILA 175
Cdd:cd17388 90 TLWWLYLGRIIAGitgaTGAVAAAYIA---DVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAAGLN 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446923700 176 TTGIALTIWVVPNSsthvLNRESgmvKGSFSKVLAEP-RLLKLNFGIMCLHILLMSTFV 233
Cdd:cd17388 166 GLNFLLGLFVLPES----LPPER---RRAFRWRRANPfGSLRWLTGFPGLLGLLAVFFL 217
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
12-181 |
8.14e-15 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 75.66 E-value: 8.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 12 RATWGLGTVFSLRMLGMF-MVLPVLTtygMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:cd17370 200 KAFWLYLLAVALFALGNFsFAFLILR---AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLAL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQGSG-AIAAAVM-ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALF 168
Cdd:cd17370 277 AYLGFALGSSLWLLLLGFILWGLYmGAQESIErAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF 356
|
170
....*....|...
gi 446923700 169 WMIAILATTGIAL 181
Cdd:cd17370 357 LFSAVLALIALLL 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-380 |
2.36e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.19 E-value: 2.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 17 LGTVFSLrmLGMFMVLPVLTTYGMALQGaSEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAA 96
Cdd:cd06173 6 LAQLLSA--LGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 97 L-----SDSIWGIILGRALQGSGAI--AAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFW 169
Cdd:cd06173 83 LlallgSLSLWLLLVLAFLLGIASAffGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 170 MIAILATTGIALTIWV---VPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLnFGIMCLHILLMSTFVALPGQLADAGFPA 246
Cdd:cd06173 163 INALSFLLSALLLLFIrrpPPAAPGESSSLLLRDLREGLRYLRRSPLLRLL-LLALALFALLGGALTVLLPLLAKEVLGG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 247 AEHWKVYLATMlIAFGSVVPFIIYAEV--KRKMKQVFVFCVGLIVVAEIVLWNAqTQFWQLVVGVQLFFVAFNLMEALLP 324
Cdd:cd06173 242 GAAGYGLLLAA-FGVGALLGALLLGRLskRRRRGRLLLIGALLLGLALLVLGLS-PSLWLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446923700 325 SLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAV 380
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-151 |
1.24e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.93 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446923700 91 GSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIA 151
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGfgFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
44-176 |
1.67e-13 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 71.59 E-value: 1.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVM-- 121
Cdd:PRK10473 34 NASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVaf 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446923700 122 ALLSDLTREQNRTKAMAFIGvsfGITFAI---AMVLGPIITHKLGLHALFWMIAILAT 176
Cdd:PRK10473 114 AILRDTLDDRRRAKVLSLLN---GITCIIpvlAPVLGHLIMLKFPWQSLFYTMAAMGI 168
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-357 |
2.96e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 71.07 E-value: 2.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTYGMALQ------GASEALIGIAIGIYGLTQAVFqIPF-GLLSDRIGRKPLIVGGLAVFAAGSVIAAL 97
Cdd:cd17503 2 LLGAFMAILDTTIVNVALPtimgdlGASLDTVQWVITSYLLALAIM-IPLsGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 98 SDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILA 175
Cdd:cd17503 81 APNLASLIIFRILQGfgGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 176 TTGIALTiwvvpnsstHVLNresgmvkgsfSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AGFPAAEhwkvyl 254
Cdd:cd17503 161 ILALLLA---------PLLD----------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFE------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 255 ATMLIAFGSVVPFIIYAEVKRKMKQV---FVFCVGLIVVAEIVLWNAQ----TQFWQLVV-------GVQLFFVAFNLMe 320
Cdd:cd17503 216 SGLVLAPGGLASAILSPLVGRLLDKFgprLLLLAGLLLLALGTLLLAFltpdTSLWLIILplfirglGMGLVFMPLNTL- 294
|
330 340 350
....*....|....*....|....*....|....*..
gi 446923700 321 allpslISKESPAGYKGTAMGVYSTSQFLGVAIGGSL 357
Cdd:cd17503 295 ------ALNSLPPEQIGDATALFNTIRQLGGSIGTAL 325
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
44-396 |
8.07e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 69.52 E-value: 8.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGaIAAAVMAL 123
Cdd:COG2807 49 GLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG-IAVGNVLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 124 LSDLTRE--QNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILAttGIALTIWVVPNSSTHVLNRESGmV 201
Cdd:COG2807 128 PGLIKRWfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLA--LLALLLWLPLLRRRPAAAAAAP-A 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 202 KGSFSKVLAEPRLLKLNFgIMCLHILLMSTFVA-LPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQV 280
Cdd:COG2807 205 AASLRSLWRSPLAWLLTL-FFGLQSLLYYAVVAwLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 281 FVFCVGLIVVAEIVLWNAQTQFWQLVVGVQ-LFFVAFNLMEALLPSLISKeSPAGYkGTAMGVYSTSQFLGVAIGGSLGG 359
Cdd:COG2807 284 LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLgLGQGGLFPLALTLIGLRAR-TPAEA-AALSGMAQSVGYLLAALGPLLVG 361
|
330 340 350
....*....|....*....|....*....|....*..
gi 446923700 360 WIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPYVSS 396
Cdd:COG2807 362 ALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-361 |
9.87e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 69.12 E-value: 9.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 31 VLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRAL 110
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 111 QG--SGAIAAAVMALLSDLTREqNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPN 188
Cdd:cd17478 94 AGigSAAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 189 SSTHVLNRESGMVKGSFSKVLAEPrLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEhwkVYLATMLIAFGSVVPFI 268
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRA-LLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF---AGLLLSLFLFAGAIGTL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 269 IYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGvqLFFVAFNLMEALLPSL-ISKESPAGYKGTAMGVYSTSQ 347
Cdd:cd17478 249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYIL--LVLAGFLLFASFPVTVvLAQELLPGNVGLASGLMMGLS 326
|
330
....*....|....
gi 446923700 348 FLGVAIGGSLGGWI 361
Cdd:cd17478 327 FGLGGIGAPVLGAL 340
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
57-184 |
1.14e-12 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 69.17 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 57 YGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVMA--LLSDLTREQNRT 134
Cdd:PRK11652 52 YLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMArtLPRDLYEGTQLR 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446923700 135 KAMAFIgvSFGITFA--IAMVLGPIITHKLGLHALFWMIAIL-ATTGIALTIW 184
Cdd:PRK11652 132 HANSLL--NMGILVSplLAPLIGGLLTTLFGWRACYLFLLLLgAGVTFSMARW 182
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
44-175 |
4.67e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 67.22 E-value: 4.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQgsGAIAAAVMAL 123
Cdd:cd17323 30 HVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ--GFFGSSPLAI 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446923700 124 ----LSDLTREQNRTKAMAFigvsfgitFAIAMVLGPI--------ITHKLGLHALFWMIAILA 175
Cdd:cd17323 108 gagtIADLFTPEERGKAMGV--------YSLGPLLGPAlgpiiggfITQSLGWRWIFWFLAIIS 163
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-187 |
5.56e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.82 E-value: 5.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 13 ATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGR--KPLIVGGLAVFAA 90
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALF 168
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGfgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170
....*....|....*....
gi 446923700 169 WMIAILATTGIALTIWVVP 187
Cdd:COG2271 341 LLLAALALLAALLALLLLR 359
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
23-366 |
1.77e-11 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 65.47 E-value: 1.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 23 LRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIW 102
Cdd:PRK11646 21 LVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPW 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 103 GIILGRALQGSGA--IAAAVMALLSDLTREQNRtkamafigvsfGITFAIAMVL---GPIITHKLG-------LHALFWM 170
Cdd:PRK11646 101 LLWLSCILSGLGGtlFDPPRTALVIKLIRPHQR-----------GRFFSLLMMQdsaGAVIGALLGswllqydFRLVCAT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 171 IAILATTGIALTIWVVPN---SSTHVLNREsGMvkgsfSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AGFPA 246
Cdd:PRK11646 170 GAVLFVLAAAFNAWLLPAyklSTVRTPVRE-GM-----TRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDiAGSPS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 247 AEHWkVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVgLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSL 326
Cdd:PRK11646 244 AVKW-MYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGL-LIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446923700 327 ISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWidgMFD 366
Cdd:PRK11646 322 SASLADARARGSYMGFSRLGLALGGAIGYIGGGW---LFD 358
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-385 |
3.98e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.16 E-value: 3.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 28 MFMVLPVLTTYGmaLQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILG 107
Cdd:cd17316 18 IGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 108 RALQG--SGAIAAAVMALLSDLTREQNRTKAMAFI--GVSFGITFA--IAMVLGPIITHKLGLHALFWMIAILAttgial 181
Cdd:cd17316 96 RFLQGigIGGEYPGASTYVAEFAPSKRRGFALGLLqsGWALGALLAalVASLLIPLLSGDWGWRILFLIGALPA------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 182 tiwvvpnssthvlnresgmvkgsFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQL-ADAGFPAAEHWKVYLATMLIA 260
Cdd:cd17316 170 -----------------------LLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLqTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 261 FGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAM 340
Cdd:cd17316 227 LVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446923700 341 GVystSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:cd17316 307 GL---SYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-185 |
4.11e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 64.52 E-value: 4.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAAL-SDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGI-TFAIAMVLGPIITHKLGLHA 166
Cdd:COG2223 284 GLLLLALaLGSLWLFLVLFLLLGlaLGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLgGFLGPLLFGALLDATGSYTA 363
|
170
....*....|....*....
gi 446923700 167 LFWMIAILATTGIALTIWV 185
Cdd:COG2223 364 AFLVFAVLALVALVLTLLL 382
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
23-193 |
6.03e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 63.76 E-value: 6.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 23 LRMLGMF---MVLPVLTTYGMALQgASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSD 99
Cdd:PRK11043 14 LSMLGFLatdMYLPAFKAIQADLQ-TSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 100 SIWGIILGRALQGSGAIAAAVM--ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATT 177
Cdd:PRK11043 93 SAAQLLVLRFVQAVGVCSAAVIwqALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLL 172
|
170
....*....|....*.
gi 446923700 178 GIALTIWVVPNSSTHV 193
Cdd:PRK11043 173 LILPTLRLKPSKKARK 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-183 |
1.19e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 62.62 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIA--ALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFI-GVSFGITFAIAMVLGPIITHKLGLH 165
Cdd:cd17316 256 LALPLfyLLSGSPTLLLLLLFILSffVGGVWGALYAYLAELFPTEVRATGVGLSyNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*...
gi 446923700 166 ALFWMIAILATTGIALTI 183
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-385 |
3.59e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.41 E-value: 3.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQGSG--AIAAAVMALLSDLTREqNRTKAMAFIGVSFGI-TFAIAMVLGPIITHKLGL--H 165
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGlgLLDVAANPYVAALGPE-TAASRLNLLHAFFSLgALLGPLLGGLLILLGLSLswH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 166 ALFWMIAILAtTGIALTIWVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFP 245
Cdd:COG0738 165 LPYLILAVLL-LLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 246 AAEHWKVYLATMLIAFgsVVPFIIYAEVKRKMKQ--VFVFCVGLIVVAEIVLWNAqTQFWQLVVGVQLFFVAFNLMEALL 323
Cdd:COG0738 244 SEATAALGLSLFWGGM--TIGRFLGGFLLKRFGPvrLLRLSALLAAVGLLLALLA-PGPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446923700 324 PSLISKESPAgYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:COG0738 321 FSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLA 381
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
22-385 |
4.36e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.04 E-value: 4.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 22 SLRMLGMFMVLPVLTTYgMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSI 101
Cdd:cd17477 6 ALLGLGSGLLLPLLSLR-LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 102 WGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHklGLHALFWMIAILATTGI 179
Cdd:cd17477 85 WVWFLLRFVMGigLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT--AGALPFLIAAVLLLLAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 180 ALtIWVVPNSSTHVLNRESGMVKGSFSKVlaePRLLklnFGIMCLHILLMSTFVALPGQLADAGFPAAEhwkVYLATMLI 259
Cdd:cd17477 163 VP-LLLTRRAAPEIEEAESISLRRLLRIA---PLAL---LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQ---AALLLAAF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 260 AFGSVV--PFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVgvqLFFVAFNLMEALLP---SLISKESPAG 334
Cdd:cd17477 233 VLGGLLlqWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLV---LLFLWGGAAGPLYTlalALAGDRLPGD 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446923700 335 YKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:cd17477 310 ELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
26-158 |
6.95e-10 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 60.30 E-value: 6.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 26 LGMFMVLPVLTTYGMAL-QGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIG--RKPLIVgGLAVFAAGSVIAAL----- 97
Cdd:cd17326 13 LQFSIVLTSIWPYLQKIdPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIV-SILIAIVGNILYALaeyfp 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446923700 98 SDSIWGIILGRALQGSGAIAAAVM-ALLSDLTREQNRTKAMAFIGVSfgitFAIAMVLGPII 158
Cdd:cd17326 92 SNRKYVMLVARFLIGVGAGNVAVLrAYVAAASTLKDRTRAMAVISAA----QALGFIVGPAL 149
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-186 |
7.30e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 60.72 E-value: 7.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 26 LGMFMVLPVLTTYGMALQGASEALIGIAIgIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGII 105
Cdd:cd06179 11 LFGVTLPAAVLPFIVADLGPSSNSTWIST-AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 106 LGRALQGSGAIAAAVM-ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGP--IITHKLGLHALFWMIAILAttGIALT 182
Cdd:cd06179 90 GGQALIGIGAGTQGLGaAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGalVEANAAGWRWIFYINAIFN--ALALI 167
|
....
gi 446923700 183 IWVV 186
Cdd:cd06179 168 LLFF 171
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-183 |
7.99e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 7.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQGSGAIAAAVM--ALLSDLTrEQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALF 168
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAlqTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
170
....*....|....*
gi 446923700 169 WMIAILATTGIALTI 183
Cdd:cd17324 356 WVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-186 |
9.24e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.92 E-value: 9.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYgMALQGASEAL--IGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVF 88
Cdd:cd17489 189 RRLVEKKVLPPALILFLASIAYGAISTF-LPLYAAERGIsnAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 89 AAGSVIAALSDSIWGIILGRALQGSGAIAA--AVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHA 166
Cdd:cd17489 268 ALGLLLLSFAGSPWMLLLAAVLYGLGFGLLfpALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRA 347
|
170 180
....*....|....*....|
gi 446923700 167 LFWMIAILATTGIALTIWVV 186
Cdd:cd17489 348 MFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-186 |
1.08e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.91 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 45 ASEALIGIAIGiygltqAVFqipFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGS--GAIAAAVMA 122
Cdd:cd17365 40 GSAALFGMAIG------ALL---AGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLglGAAMPNAIT 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446923700 123 LLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWM-----IAILATTGIALTIWVV 186
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLggvppLILLPLLRGTLLLWVT 179
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
46-189 |
1.13e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 60.06 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 46 SEALIGIAIGiygltqavfQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQ--GSGAIAAAVMAL 123
Cdd:TIGR00895 59 SAGLIGMAFG---------ALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAglGLGGLMPNLNAL 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446923700 124 LSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNS 189
Cdd:TIGR00895 130 VSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPES 195
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-186 |
1.49e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.92 E-value: 1.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 12 RATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAG 91
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 92 SVIAALS--DSIWGIILGRALQG--SGAIAAAVMALLSDL-------TREQNRTKAMAFIGVSFGITFAIAMVLGPIITH 160
Cdd:COG2211 308 LLLLFFLgpGNLWLLLVLAALAGigLGAILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180 190
....*....|....*....|....*....|....*..
gi 446923700 161 KLG-----------LHALFWMIAILATTGIALTIWVV 186
Cdd:COG2211 388 LFGyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLL 424
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
25-382 |
1.63e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 59.20 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTY----GMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGglAVFAAGSVIA--ALS 98
Cdd:cd17391 9 GIGFSLIAPFLPLYieqlGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLR--ASLGMAIVIGlmAFV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 99 DSIWGIILGRALQG--SGAIAAAvMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILAT 176
Cdd:cd17391 87 TNVWQLLILRLLQGvfSGYVPNA-TALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 177 TGIALTIWVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAehwKVYLAT 256
Cdd:cd17391 166 LAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDAS---NLAFIS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 257 MLIAFGSVVPFIIYAEVKRKMKQVF----VFCVGLIVVAEIVLWNAQTQ-FWQLvvGVQLFFVAFnLMEALLP---SLIS 328
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIghhrILLGALLASALLYIPQAFVQtPWQL--GILRFLLGL-ATGGLLPainSLLA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446923700 329 KESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGA---MLAAVWL 382
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTAllvLLNAIWS 376
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
25-386 |
1.98e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTYgMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIG--RKPLIVGGLAVFAAGSVIAALSDSIW 102
Cdd:cd17335 10 FAALGSLLPFLSVY-LKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkrKALLLLSLLAAVLFFLSLFFVAQIFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 103 GIILGRALqgSGAIAAAVMAL-----LSDLTREQNRTKAMAFIG-VSFGITfaiAMVLGPIITH---KLGLHALFWMIAI 173
Cdd:cd17335 89 LLLLLVIL--GAFFSAPVVPLvdsitLQYLGEERERYGKQRLWGsIGFGIA---ALLVGILIDRsstYKNYTIAFYVFAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 174 LATtGIALTIWVVPNSSTHvlnRESGMVKGSFSKVLAEPRLLKLNF--GIMCLHILLMSTFVALpgQLADAGfpaaehWK 251
Cdd:cd17335 164 LML-LALLLALKFPFRPKH---PEPNENTGGLLALLRNPRVLAFLLvaFLMGFGHGLIYSFLFW--HLQDLG------GS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 252 VYLATMLIAFGSV---VPFIIYAEVKRKMKQVFVFCVGLIV-VAEIVLWNAQTQFWqLVVGVQLFF-VAFNLMEALLPSL 326
Cdd:cd17335 232 KTLIGLLWTVGVVseiPFFFFSSRLIQRFGHVGLLYLGLLAyVVRWLLYSFLENPW-LVLPIELLHgLTFALVWAAAVSY 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446923700 327 ISKESPAGYKGTAMGVYSTSQF-LGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVAS 386
Cdd:cd17335 311 ASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-380 |
2.73e-09 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 58.71 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 26 LGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIG-RKPLIVGGLAVFAAGSVIAALSDSIWG- 103
Cdd:cd17471 10 LAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVl 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 104 IILGRALQGSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGP----IITHKLGLHALFWMIAILATTGI 179
Cdd:cd17471 90 LLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPplafLLLDVLGFTGLFLLAALLYLVVA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 180 ALTIWVVPNSSTHVLNRESgmvKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADaGFPAAEHWKVYLatMLI 259
Cdd:cd17471 170 LLVLFLLPSVKPPAQKATP---ASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTN-ELGGSESWVGLL--FGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 260 AFGSVVPFIIYAEV-KRKMKQVFVFCVGLI--VVAEIVLWNAqTQFWQLVVGvQLF---FVAF------NLMEALLPsli 327
Cdd:cd17471 244 AAALEIPIMLLAGLlAKRFGKRRLLLAGFLagVLFYLGLALA-TSLWQLIAL-QLLnaiFIGItaglgiSYFQDLMP--- 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446923700 328 skespaGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAV 380
Cdd:cd17471 319 ------GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
49-354 |
4.01e-09 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 58.05 E-value: 4.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 49 LIGIAIG-IYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG-SGAIAAAVMALLSD 126
Cdd:cd17389 64 LFGGLIGsLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGiSKGNVSLSTAIVAD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 127 LTREQNRTKAMAFIGVSFGITFAIAMVLGPI--ITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLnresgmvkgs 204
Cdd:cd17389 144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGAYfaSFTRSLGEVFFSMPALFALVLALADLLFIFFFLPETL---------- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 205 fskvlaePRLLKLNFGIMCLHILLMS----TFVALPGQLADagFPAAEHWKVYL---ATMLIAFGSVVPFIIYAEVKRKM 277
Cdd:cd17389 214 -------PSNLRRLGLVYFLYLFLFSglefTLTFLTHQRFQ--YTSMQQGKMFFfigIIMALVQGGYVRRIKPGKEKKAV 284
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446923700 278 KQVFVFCV-GLIVVAeivlWNAQTqfWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIG 354
Cdd:cd17389 285 LQGLILLIpAFLLIG----WASSV--TVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALG 356
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
23-158 |
4.36e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 58.01 E-value: 4.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 23 LRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIW 102
Cdd:cd17390 7 LDLFGVSMILPLLSTHIRSL-GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446923700 103 GIILGRALQG-SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFaiamVLGPII 158
Cdd:cd17390 86 LLFLSRIPLGiFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGF----ILGPVV 138
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
23-188 |
7.93e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 57.27 E-value: 7.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 23 LRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIW 102
Cdd:cd17476 9 LNQAGLGSVIVILPIIGDSF-GTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 103 GIILGRALQGSGA--IAAAVMALLSDLTREQNRTK-AMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAIL-ATTG 178
Cdd:cd17476 88 FFIICRALQGLGPafLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILaAIVA 167
|
170
....*....|
gi 446923700 179 IALTIWVVPN 188
Cdd:cd17476 168 VAAIFWTSPS 177
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
46-163 |
1.36e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.48 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 46 SEALIGIAIGIYG-----LTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSG--AIAA 118
Cdd:cd17328 27 SDFLIDDSLAGLLqtvfiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGeaSYSP 106
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446923700 119 AVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLG 163
Cdd:cd17328 107 IAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG 151
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
30-385 |
1.58e-08 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 56.43 E-value: 1.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 30 MVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWG------ 103
Cdd:PRK05122 33 LPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGLLAAwpvlsl 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 104 --IILGRALQGSGAIAAAVMALLSDLTR--EQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGI 179
Cdd:PRK05122 113 llLLLGRLLLGIGESLAGTGSILWGIGRvgALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGLGLLIMLLALLGL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 180 ALtIWVVPNSSTHVLNRESgmvkgsFSKVLAEPRLLKLNFGIMCLHILLMSTFVALpgqladagFPAAEHWKvYLATMLI 259
Cdd:PRK05122 193 LL-ARPRPAVPPVKGERLP------FRRVLGRVWPYGMGLALASIGFGTIATFITL--------YYAARGWD-GAALALT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 260 AFGsvVPFI------IYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVvGVQLFFVAFNLMEALLPSLISKESPA 333
Cdd:PRK05122 257 LFG--VAFVgarllfGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALI-GAALTGFGFSLVFPALGVEAVKRVPP 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446923700 334 GYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:PRK05122 334 QNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALT 385
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
32-373 |
2.16e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 55.71 E-value: 2.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 32 LPVLTTYgMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIG-RKPLIVGGL---AVFAAGSVIAALSDSIWGIILG 107
Cdd:pfam12832 19 LPYWGLY-LRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASilaAVLFLSVLFIPISLTFWWLALL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 108 RALqGSGAIAA-------AVMALLSDLTREQNRTKAmaFIGVSFGITfaiAMVLGPIITHkLGLHALFWMIAILATtGIA 180
Cdd:pfam12832 98 VVL-FSFFWNAilpqfevATLQHLGEKRKDYGRQRL--WGSVGFALS---VFGLGALFDH-YSVGLLPSVLFYLFA-ALM 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 181 LTIWVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLklnfgIMCLHILLMSTFVALPGQ-----LADAGFPAaehwkvYLA 255
Cdd:pfam12832 170 LLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVI-----IFFLAAFLLGFSHGPFYTflflyLENLGASN------TLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 256 TMLIAFGSV--VPFIIYAE-VKRKMKQVFVFCVGLIVVA-EIVLWNAQTQFWQLVVGVQLFF-VAFNLMEALLPSLISKE 330
Cdd:pfam12832 239 GALWALGVVaeIPLFFYAHrLLRRFGHRNLLIIALLLTAlRWLLYAFFVENPWLVLPIQFLHaISFGLTHAAAIEYVRRI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 446923700 331 SPAGYKGTAMGVYSTSQF-LGVAIGGSLGGWIDGMFDGQGVFLA 373
Cdd:pfam12832 319 FPGSLQGTGQALYSGLYFgLGGALGSLIGGQLWDLFGARFTFRA 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-183 |
3.99e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 55.13 E-value: 3.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDR-IGRKPLIVGGLAVFA 89
Cdd:cd06174 202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 90 AGSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIA-MVLGPIITHKLGLHA 166
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGfgLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGpLLAGFLLAATFGLTG 361
|
170
....*....|....*..
gi 446923700 167 LFWMIAILATTGIALTI 183
Cdd:cd06174 362 AFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-186 |
6.00e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.54 E-value: 6.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:cd17329 199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAALSDSIWGIILGRALQGSGAIAA--AVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALF 168
Cdd:cd17329 279 GFAVLAFANTLAVLILAMIVLTLGEMLVfpAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
170
....*....|....*...
gi 446923700 169 WMIAILATTGIALTIWVV 186
Cdd:cd17329 359 LILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
68-387 |
6.83e-08 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 54.15 E-value: 6.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 68 FGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGR-------ALQGSGAIAaavmallSDLTREQNRTKAMAFI 140
Cdd:cd17331 55 FGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRlpsvfmhAMQAAQMVV-------TDLTDPGERAAALGRL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 141 GVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVP-NSSTHVLNRESGMVKGSFSKVLAEPRLLKLNF 219
Cdd:cd17331 128 GLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPsNTKSKREKEAKESASPPSVFNLKEILRLLRLP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 220 GIMCLhiLLMSTFVALPGQLADAGFP--AAEHWKV------YLATMLIAFGSVVPFIIYAEVKRKM--KQVFVFCVGLIV 289
Cdd:cd17331 208 GVAFL--LLVKLLSGLPIGMFQSMFSlvAMDFFGLtpeengYLMSYAGVLGMVVQGLLVGPLTKRFgeRSLLKLSVALLA 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 290 VAEIVLWNAQTQfWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQG 369
Cdd:cd17331 286 IGYLLLAFVTTV-WQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPS 364
|
330
....*....|....*...
gi 446923700 370 VFLAGAMLAAVWLAVAST 387
Cdd:cd17331 365 FGLLGAAINGLLTVYLLL 382
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
50-247 |
7.10e-08 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 54.12 E-value: 7.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 50 IGIAIGIYGLTQAVFQIPFGLLSDRIG-RKPLIVGGLAVFAAgSVIAALSDSIWGIILGRALQGSGAIAAAV--MALLSD 126
Cdd:cd17384 33 VGLLFASKALVQLITNPIVGPLTNRIGySLPMFVGFVIMFIS-TLLFAFGESYGVLFLARALQGVGSACSSVagMGMLAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 127 L-TREQNRTKAMAF------IGVSFGITFaiamvlGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSThvlnRESG 199
Cdd:cd17384 112 LyPDDKERGKAMGIalgglaLGVLVGPPF------GGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVK----SEES 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446923700 200 MVKGSFSKVLAEPRLLKLNFGIM-----------CLHILLMSTFVALPGQLADAGFPAA 247
Cdd:cd17384 182 EEGTPWKTLLKDPYILIAAGAICfsnsgiailepCLPIWMMETMCPPKWQLGTAFLPDS 240
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
30-385 |
7.36e-08 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 54.30 E-value: 7.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 30 MVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKP-LIVGGLAVFAAGS---------VIAALSD 99
Cdd:PRK12382 33 LPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRsALQGMLACGLAGLayllaailpVSAPFKF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 100 SIwgIILGRALQGSGA--IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATT 177
Cdd:PRK12382 113 AL--LVVGRLILGFGEsqLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHSHFGFAALALTTMVLPLL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 178 GIALTIWVvPNSSTHVLNRESgmvkgsFSKVLAEPRLLKLNFGIMCLHILLMSTFVALpgqladagFPAAEHWKVYLATm 257
Cdd:PRK12382 191 AWAFNGTV-RKVPAHAGERPS------LWSVVGLIWKPGLGLALQGVGFAVIGTFVSL--------YFASKGWAMAGFT- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 258 LIAFGS--VVPFIIYAEVKRKMKQVFVFCVGLIV--VAEIVLWNAQTQfWQLVVGVQLFFVAFNLMEALLPSLISKESPA 333
Cdd:PRK12382 255 LTAFGGafVLMRVLFGWMPDRFGGVKVAIVSLLVetVGLLLLWLAPTA-WVALAGAALTGAGCSLIFPALGVEVVKRVPS 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446923700 334 GYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVA 385
Cdd:PRK12382 334 QVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVT 385
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
43-189 |
2.00e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 53.04 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 43 QGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSD---SIWGIILGRALQG--SGAIA 117
Cdd:pfam00083 41 LAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGigVGGAS 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446923700 118 AAVMALLSDLTREQNRTK--AMAFIGVSFGITFAIAMVLGPIITHK-LGLHALFWMIAILATTGIALtIWVVPNS 189
Cdd:pfam00083 121 VLAPMYISEIAPKKLRGAlgSLYQLAITFGILLAYIFGLGLNKTSNsDGWRIPLGLQLVPALLLIIG-LLFLPES 194
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
17-384 |
2.15e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 52.66 E-value: 2.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 17 LGTVFSLRMLGMFMVLPVLTTYGmalqgASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAA 96
Cdd:cd17355 12 LILSWGIRYYFGVFIIPIIAEFG-----WSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 97 LSDSIWGIILGRAL---QGSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGL-HALFWMIA 172
Cdd:cd17355 87 LATSLWQLYLLWGLlggGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrTALLVLAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 173 ILATTGIALTIWVVPNSSTHVLNRESGMVKGSFSKVLAEP------RLLKLNFGIMCLHilLMSTFVALPGQLADAGFPA 246
Cdd:cd17355 167 LALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEAlrsasfWLLALAFFLCGFA--VVGLIVHLVPYLADRGISP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 247 AEhwkVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIV--VAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLP 324
Cdd:cd17355 245 AA---AAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALraLGLALLLLLPFPPLALLLFAALFGLGWGATVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 325 SLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAV 384
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
25-188 |
3.13e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 52.38 E-value: 3.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFM------VLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALS 98
Cdd:TIGR00711 8 MLGTFMavldstIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 99 DSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMAFigvsFGITFAIAMVLGPI----ITHKLGLHALFWMIA 172
Cdd:TIGR00711 88 PNLELMIIFRVIQGfgGGPLIPLSFSTLLNIYPPEKRGRAMAI----WGLTVLVAPALGPTlggwIIENYHWRWIFLINV 163
|
170
....*....|....*.
gi 446923700 173 ILATTGIALTIWVVPN 188
Cdd:TIGR00711 164 PIGIIVVVVAFFILPR 179
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
5-181 |
3.33e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 52.16 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 5 KMTPGERRATWGLGTVFSLRMLGMFM---VLPVLTTYGMalqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLI 81
Cdd:cd17471 192 LVKAPVNRRLLLLFAAFTLLFAANSMyiiAMPLYVTNEL---GGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 82 VGGLAVFAAGSVIAALSDSIWGIILGRALQGS--GAIAAAVMALLSDLTREQnRTKAMAFIGVSFGITFAIAMVLGPIIT 159
Cdd:cd17471 269 LAGFLAGVLFYLGLALATSLWQLIALQLLNAIfiGITAGLGISYFQDLMPGQ-PGLATTLYSNASRIGSLLGGLLAGVIA 347
|
170 180
....*....|....*....|..
gi 446923700 160 HKLGLHALFWMIAILATTGIAL 181
Cdd:cd17471 348 QYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-184 |
4.26e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.81 E-value: 4.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 15 WGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPF-GLLSDRIGRKPLIVGGLAVFAAGSV 93
Cdd:cd17330 177 RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 94 IAALSDSIWGIILGRALQGSGAIAA--AVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMI 171
Cdd:cd17330 257 LLPFASSVPLLVLAAAILAFGTGIVfpALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336
|
170
....*....|...
gi 446923700 172 AILATTGIALTIW 184
Cdd:cd17330 337 AGLLLIALFLLSL 349
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
15-183 |
4.32e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.79 E-value: 4.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 15 WGLGTVFSLRMLGMFMVLPVLttygMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVI 94
Cdd:cd17478 201 LIIVFLRSWVLSSLTTFLPFY----LVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 95 AALSDSIWGIILgraLQGSGAIAAAVMALLSDLTREQNRTKA-MA---FIGVSFGITFAIAMVLGPIITHkLGLHALFWM 170
Cdd:cd17478 277 FLLTPGIWSYIL---LVLAGFLLFASFPVTVVLAQELLPGNVgLAsglMMGLSFGLGGIGAPVLGALADA-FGLESVLLI 352
|
170
....*....|...
gi 446923700 171 IAILATTGIALTI 183
Cdd:cd17478 353 LALLPLLGALLAF 365
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
37-187 |
5.95e-07 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 51.65 E-value: 5.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 37 TYGMALQGASEALIGIaIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA- 115
Cdd:PRK14995 31 TLSMTLGASGNELLWI-IDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAa 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446923700 116 --IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVP 187
Cdd:PRK14995 110 miVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVP 183
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
44-392 |
6.00e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 51.48 E-value: 6.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVM 121
Cdd:PRK15402 44 NAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLcfIGAVGY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 122 ALLSDLTREQNRTKAMAFIG-VSFgitfaIAMVLGP----IITHKLGLHALFWMIAILATtgIALT-IWVVPNSSTHVLN 195
Cdd:PRK15402 124 AAIQESFEEADAIKITALMAnVAL-----LAPLLGPlvgaALIHVLPWRGMFVLFAALAA--LSFFgLWRAMPETAGRVG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 196 ResgmvKGSFSKVLAEPRLLKLNFGIMCLHILLmsTFVALP-----GQ-----LADAGFPAAEH--WKVYLATMLIAFGS 263
Cdd:PRK15402 197 E-----KLSLKELGRDYKLVLKNRRFVAGALAL--GLVSLPllawiALspvilISGEQLSSYEYglLQVPVFGALIAGNL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 264 VVPFIIYaevKRKMKQVFV-----FCVGLIVVAEIVLWNAQTQFWqLVVGVQLFFVAFNLMEALLPSLISKESPAGyKGT 338
Cdd:PRK15402 270 TLARLTS---RRPLRSLIRmglwpMVAGLLLAALATVISSHAYLW-LTAGLSLYAFGIGLANAGLYRLTLFSSDVS-KGT 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446923700 339 AMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLA-VASTMKEPP 392
Cdd:PRK15402 345 VSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLlVRIFLKDKP 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
44-188 |
7.14e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.03 E-value: 7.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG--SGAIAAAVM 121
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGvaEAGFFPGAI 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446923700 122 ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPN 188
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ 180
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-175 |
1.43e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.38 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 29 FMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGR 108
Cdd:cd17371 15 LLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446923700 109 ALQ--GSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLG----PIITHKLGLHALFWMIAILA 175
Cdd:cd17371 95 ALAglGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAallfPLLPPEIAWRVLFLLGALPA 167
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
4-184 |
1.72e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 4 YKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFqipFGLLSDRIGRKPLIVG 83
Cdd:cd06173 203 YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL---LGRLSKRRRRGRLLLI 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 84 GLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAV--MALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHK 161
Cdd:cd06173 280 GALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVplNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
|
170 180
....*....|....*....|...
gi 446923700 162 LGLHALFWMIAILATTGIALTIW 184
Cdd:cd06173 360 LGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
56-159 |
4.38e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 48.35 E-value: 4.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 56 IYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNR 133
Cdd:cd17317 33 IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGvtSAGIFTVGFVLGMEIVGPKYR 112
|
90 100
....*....|....*....|....*.
gi 446923700 134 TkamaFIGVSFGITFAIAMVLGPIIT 159
Cdd:cd17317 113 S----FVGILFGLFWALGYMLLALLA 134
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-385 |
4.83e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.39 E-value: 4.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 46 SEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAA------A 119
Cdd:cd17475 29 SLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVqpgggrA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 120 VMALLsdltREQNRTKAMAF--IGVSFGItfAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRE 197
Cdd:cd17475 109 IMRWF----PPRERGLAMGIrqTGVPLGG--ALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 198 SGMVK-GSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADA-GFP-AAEHWKVYLATMLIAFGSVVPFIIYAEVK 274
Cdd:cd17475 183 SASTLlRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSvVAAGALLAVAQLGGALGRIGLGRVSDRVF 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 275 RKMKQVFVFCVGLIVVAEIV---LWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGV 351
Cdd:cd17475 263 GGRRRPVLVITAAIAAAALLvlsLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGI 342
|
330 340 350
....*....|....*....|....*....|....*.
gi 446923700 352 AIGGSLGGWI-DGMFDGQGVFLA-GAMLAAVWLAVA 385
Cdd:cd17475 343 AIGPPLFGLLvDATHSYAPAWLAlALLLVLAALLLL 378
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
69-186 |
5.21e-06 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 48.43 E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 69 GLLSDRIGRKPLIVGGLAVFAAGSVIAALS------DSIWGIILGRALQ----GSGAIAAAVMALLSDLTREQNRTKAMA 138
Cdd:cd17386 51 GSWSDRYGRKPPLLMSLVGLLLSSLILVLIvyfttvPSVWWFYLSAIPLalfgGFTAFLSASFAYISDISSEKKRTYRMA 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 446923700 139 FIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVV 186
Cdd:cd17386 131 ILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL 178
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
44-380 |
5.54e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.39 E-value: 5.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDR----IG-RKPLIVgglavfaAGSVIAALSDSI--WGIILGRALQGSGAI 116
Cdd:cd17313 30 GLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFIL-------VGAPLAALGLILipNAADIGLALGDGPRT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 117 AAAVM--------------------ALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHAL--------F 168
Cdd:cd17313 103 WALVLfvlgivlldfamnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFAlggnlkvpF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 169 WMIAILATTGIALTIWVV------PNSSTHVLNRESGMVKGSFSKVLAEprlLKLNFGIMCLHILLmsTFVAL-PGQLAD 241
Cdd:cd17313 183 YIGAIILLVCVLVTLFFVkepplsPEAGEHSENPSLGEVLKSLLKLLKI---MPRSLLRLLLVIFF--WWIAFfPFELFF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 242 AGFPAAEHWK------------VYLATMLIAFGSVVpFIIYAEVKRKMKQ-----------VFVFCVGLIVVAeivLWNA 298
Cdd:cd17313 258 TDYMGEEVYHgtsaasshygagVRMGAWGLLIFSLA-FLIFSLPIGKLGKkigrkkvyligLVLFAVGMALMA---LVHN 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 299 QTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYkGTAMGVYSTSQFLGVAIGGSLGGWIDgMFDGQGVFLAGAMLA 378
Cdd:cd17313 334 VTVALVLFALGGIGWATININPYPLVSDYHSESGRGQ-GTDTGLLNLAISLAQILVSLLAGPII-DVKGYGTVFPVAAVA 411
|
..
gi 446923700 379 AV 380
Cdd:cd17313 412 SF 413
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
68-289 |
7.14e-06 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 48.00 E-value: 7.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 68 FGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG---SGAIAAAVMALLSDLTREQnRTKAMAFIGVSF 144
Cdd:PRK12307 73 FGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGmgmAGEYACASTYAVESWPKHL-KSKASAFLVSGF 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 145 GITFAIAMVLGPIITHKLGLHALFWmIAILAttgIALTIWV---VPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFG- 220
Cdd:PRK12307 152 GIGNIIAAYFMPSFAEAYGWRAAFF-VGLLP---VLLVIYIrarAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNr 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 221 -----IMCLHILLMSTFVA-------LPGQLADAGFPAAehwkVYLATMLIA-FGSVVPFIIYAEVKRKMKQVFVFCVGL 287
Cdd:PRK12307 228 aqfplTLCVFIVLFSIFGAnwpifglLPTYLAGEGFDTG----VVSNLMTAAaFGTVLGNIVWGLCADRIGLKKTFSIGL 303
|
..
gi 446923700 288 IV 289
Cdd:PRK12307 304 LM 305
|
|
| PUCC |
pfam03209 |
PUCC protein; This protein is required for high-level transcription of the PUC operon. |
49-359 |
3.23e-05 |
|
PUCC protein; This protein is required for high-level transcription of the PUC operon.
Pssm-ID: 367394 Cd Length: 401 Bit Score: 45.81 E-value: 3.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 49 LIGIAIGIYGLTqAVFQIPFGLLSDRIG-----RKPLIVGGLAVFAAGSVIAALS--------------DSIWGIILGRA 109
Cdd:pfam03209 16 LVGAMIALPQLV-APFRALIGFRSDTHRalgwkRTPYIWLGSLAQAGGLAIMPFAlivlsgsgdangapTWAGLILAAVA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 110 LQ----GSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTI-- 183
Cdd:pfam03209 95 FLlyglGVHMSQTPGLALAADLADEERRPKVVGIMWVMLLIGIIVSAITVGWLLDDYTPARLIRVIQGVALITFVLNIia 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 184 -W---VVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHI-LLMSTFVALPGQLADAGFPAAEHWKVylaTML 258
Cdd:pfam03209 175 lWkieVGRPSRPAERPEQDPSFLEAWLLLVAEPQALIFLFFLFLGTLaFFMQDVILEPYGGEVFGLTVGETTKL---TAF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 259 IAFGSVVPFIIYAEVK----RKMKQVFVFC-VGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPA 333
Cdd:pfam03209 252 FAGGTLVGFGLAGRVLspglGPGRLAGLGClLGLPSFLALILAGLLGNVALFFAGVLLFGLGGGLFTVAALTAMMDLAPE 331
|
330 340
....*....|....*....|....*.
gi 446923700 334 GYKGTAMGVYSTSQFLGVAIGGSLGG 359
Cdd:pfam03209 332 GRAGTALGAWGAAQATAAGLAGLLGG 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-152 |
3.26e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 19 TVFSLRMLGMFMVLPVLTTYGMALqGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALS 98
Cdd:pfam07690 207 LALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446923700 99 DSIWGIILGRALQ-----GSGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAM 152
Cdd:pfam07690 286 SLTLSSLWLLLALlllgfGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-165 |
3.27e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 11 RRATWGLGTVFSLrMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAA 90
Cdd:cd17321 168 RTFSGAVLAAFLL-GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIAAL---SDSIWGIILGRALQGSG---AIAAAVMALLSDLTREQnRTKAMAFIGV--SFGITFAIAmVLGPIITHKL 162
Cdd:cd17321 247 GLLLLALlgaDSSVWLLLPGLVLLGLGlglFATPLTNAALSSVPKEK-AGAASGILNTarQLGGALGVA-LLGALLTAGL 324
|
...
gi 446923700 163 GLH 165
Cdd:cd17321 325 SAN 327
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
29-112 |
4.74e-05 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 45.43 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 29 FMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAAL---SDSIWGII 105
Cdd:cd17366 210 YMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLlmnSGSIAAIF 289
|
....*..
gi 446923700 106 LGRALQG 112
Cdd:cd17366 290 IGLLVLG 296
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
15-185 |
5.72e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.29 E-value: 5.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 15 WGLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVI 94
Cdd:cd17353 216 WLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 95 AALS-DSIWGIILGRALQGS--GAIAAAVMALLSDLTREQNRTKAMAFIGVSFGitfaIAMVLGPIIT----HKLGLHAL 167
Cdd:cd17353 296 LPFIgSVAVLFVLGVALIGFcyGGGFALFPALTADFFGTKNAGTNYGLLYTAKG----VGGLIGPIIAayvlYTGGYNAA 371
|
170
....*....|....*...
gi 446923700 168 FWMIAILATTGIALTIWV 185
Cdd:cd17353 372 FIIAAALSLVALALALLL 389
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
44-189 |
7.36e-05 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 44.93 E-value: 7.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALS-DSIWGIILGRALQGSGAIAAAVMA 122
Cdd:cd17356 41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLV 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446923700 123 --LLSDLTREQNRTKAMAFIG--VSFGITFAIAMVLGpiiTHKLGLHALF---WMIAILATTGIALTIWVVPNS 189
Cdd:cd17356 121 pvYQSEVAPKHIRGTLVSLYQlaITIGILVAYCINYG---THKLDGSAQWripLGLQIVWGLLLLIGMFFLPES 191
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
25-388 |
8.95e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 8.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTYG------MALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALS 98
Cdd:cd17352 9 FLVNFFTDGILNSFGvlfvelLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 99 DSIWGIILGRA-LQGSG---AIAAAVMALLSDLTREQNRTKAMAFIGVSFGItfaiaMVLGPIITHKLGLHALFWMIAIL 174
Cdd:cd17352 89 TSLWQLYLTYGvLGGLGlglIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGT-----FVFPPLLRYLLDNYGWRGALLIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 175 AttGIALtiwvvpnssthvlnreSGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAGFPAAEhwkVYL 254
Cdd:cd17352 164 G--GLCL----------------NLCVCGLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESD---AAF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 255 ATMLIA----FGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTqFWQLVVGVQLFFVAFNLMEALLPSLISKE 330
Cdd:cd17352 223 LLSIIGisdiVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATT-YVGLIVFSVLFGFCSGSYSSLTPVILADL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446923700 331 SPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIdgmFDGQGVFLAGAMLAAVWLAVASTM 388
Cdd:cd17352 302 VGLEKLSNAYGLVLLFQGLAALVGPPIAGLL---RDYTGDYDAAFYFCGACLLLSGVL 356
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
278-392 |
9.08e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 9.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 278 KQVFVFCVGLIVVAEIVLWNAQTqFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSL 357
Cdd:COG2814 75 RRVLLLGLLLFALGSLLCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
90 100 110
....*....|....*....|....*....|....*.
gi 446923700 358 GGWIDGMFDGQGVFLAGAMLAAV-WLAVASTMKEPP 392
Cdd:COG2814 154 GGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESR 189
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
69-175 |
9.14e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.49 E-value: 9.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 69 GLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVMA--LLSDLTREQNRTK--AMAFIGVSF 144
Cdd:cd17315 55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVplYISEIAPAKIRGAlgTLNQLMITF 134
|
90 100 110
....*....|....*....|....*....|.
gi 446923700 145 GITFAIAMVLGPIITHKLGLHALFWMIAILA 175
Cdd:cd17315 135 GILLAYLLGLALSLSPPGWWRLMFALAAVPA 165
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
35-185 |
1.06e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.46 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 35 LTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG-- 112
Cdd:COG0738 233 LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGlg 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446923700 113 SGAIAAAVMALLSDLTREqNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWV 185
Cdd:COG0738 313 LSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
16-365 |
1.13e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.13 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 16 GLGTVFSLRMLGMFMVLPVLTTYGMALqgaseALIGIAIGIYGLTQAVFQIPFGLLSDRI-----GRKPLIVGGLAVFAA 90
Cdd:cd17332 8 DFGNNLIFQIVSTYLLFFYTDVLGLSA-----AAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 91 GSVIA-------ALSDSIWGIILGRALQ-GSGAIAAAVMALLSDLTREQN-RTKA----MAFIGVSFGITFAIAMVLGPI 157
Cdd:cd17332 83 LFVLLfttpdgsGTGKLIYALITYILLDlLYTLVNIPYTALIPELTDDPEeRTSLtswrMFFATIGGLLVTVLPPPLVAY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 158 ITHKLGLHALFWMIAILATTGIALTIWVVPNS----STHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFV 233
Cdd:cd17332 163 FGGGNASRGYFLTALIIGIIGIILLLICFFGTrervVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 234 ALPGQLADAgFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQ-TQFWQLVVGVQLF 312
Cdd:cd17332 243 VLVYYFKYV-LGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpGNLVLILVLAVLA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 313 FVAFNLMEALLPSLISKESPAGYK-------GTAMGVYSTSQFLGVAIGGSLGGWIDGMF 365
Cdd:cd17332 322 GIGYGGANLLPWAMLADVIDYGELktgkrreGIFYSVMTFFRKLGLALAGALVGLILSLA 381
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
69-380 |
1.38e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 69 GLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTrEQNRTKAMAFIGVSFGI 146
Cdd:cd17333 52 GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGlgAGILDTGANTFVGALF-EESSATRLNVLHGFFGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 147 TFAIA-MVLGPIITHKLGLHALFWMIAILATTGIALtiWVVPNSSTHVLNRESGMVKGSFSKVLAE----PRLLKLNFGI 221
Cdd:cd17333 131 GALIGpLIATSLLTSELSWSWAYLIIGLIYLLLAIL--ILLTLFPELPSARNPQQSVGAFSASASRllrnPSIILGALAL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 222 MCLHILLMSTFVALPGQLADAGFPAAEhwkvyLATMLIA---FGSVVPFIIYAEVKRKMKQ---VFVFCVGLIVVAEIVL 295
Cdd:cd17333 209 FLYVGAETAFSSWVPSYLVEKKHVSDG-----LAGYLLSgfwVGITIGRLLGGPISRRIKPhtlLVLSGSGALLGLLILL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 296 WNaQTQFWQLVVGVQLFFVafnlMEALLPSLISK--ESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLA 373
Cdd:cd17333 284 LA-PTLVVGLVATALLGLF----MAALFPTILSLgiSNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLL 358
|
....*..
gi 446923700 374 GAMLAAV 380
Cdd:cd17333 359 ITILYAI 365
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
25-175 |
2.29e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.28 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 25 MLGMFMVLPVLTTYGMA----LQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGG---LAVFAAGSVIAAL 97
Cdd:cd17369 237 RLAENVLFYLFTTFALSyatqTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGallAALFAFPFFWLLD 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 98 SDSIWGIILGrALQGSGAIAAAVMALLSDLTREQNRTKaMAFIGVSFG--ITFAIAMVLGPIITHKL-----GLHALFWM 170
Cdd:cd17369 317 TGSTWLIVLA-AVVVLGVLHGMMYGPQAAFLAELFPTR-VRYTGASLGyqLGAILGGGFAPLIATALvaatgSWWPVALY 394
|
....*
gi 446923700 171 IAILA 175
Cdd:cd17369 395 LAALA 399
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
65-175 |
2.89e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.93 E-value: 2.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 65 QIPFGLLSDRIGRKplIVGGLAVFAAGS----VIAALSDSIWGIILGRALQG--SGAIAAAVMALLSDLTREQNRTKAMA 138
Cdd:cd17380 51 QVLGGYLADRFGGK--KVLLLAVALWSLatllTPLLAYSSLPLLILSRILLGlgEGVHFPSMTSLFSRWVPVSERSRAVS 128
|
90 100 110
....*....|....*....|....*....|....*....
gi 446923700 139 FI--GVSFGITFaiAMVLGPIITHKLGLHALFWMIAILA 175
Cdd:cd17380 129 IVtaGSYLGTLL--GGLIGPLLLEYYGWPSVFYFFGLLG 165
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
52-149 |
3.28e-04 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 42.68 E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 52 IAIGIYGLTQAVFQI---PF-GLLSDRIG-RKPLIVGgLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAA--AVMALL 124
Cdd:cd17383 30 IAIGVLFASKAIVQLlvnPFsGTLIDRVGyDIPMMIG-LTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFAdtAGLAMI 108
|
90 100 110
....*....|....*....|....*....|
gi 446923700 125 SD-LTREQNRTK----AMAFIgvSFGITFA 149
Cdd:cd17383 109 ADrFTEEAERSKalgiALAFI--SFGCLVA 136
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
46-388 |
3.29e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 42.96 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 46 SEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQgsgAIAAAVM---- 121
Cdd:PRK03545 42 QTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGI---AFAHAIFwsit 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 122 -ALLSDLTREQNRTKAMAFIGVSfgitFAIAMVLG----PIITHKLGLHALFWMIAILATTGIALTIWVVPN-SSTHvln 195
Cdd:PRK03545 119 aSLAIRVAPAGKKAQALSLLATG----TALAMVLGlplgRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPLlPSEH--- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 196 resgmvKGSFSKVlaePRLLKlNFGIMCLHILLMSTFVAL--------PGQLADAGFPAAehwkvyLATM-LIAFGS--V 264
Cdd:PRK03545 192 ------SGSLKSL---PLLFR-RPALVSLYLLTVVVVTAHftaysyiePFVQQVAGLSEN------FATLlLLLFGGagI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 265 VPFIIYAEVKRKMKQVFVFC-VGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGyKGTAMGVY 343
Cdd:PRK03545 256 IGSVLFSRLGNRHPSGFLLIaIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKLAPDA-TDVAMALF 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446923700 344 STSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTM 388
Cdd:PRK03545 335 SGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSILI 379
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
48-186 |
4.71e-04 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 42.49 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 48 ALIGIAIGIYGLTQaVFQIPFGLLSDRIG-----RKPLIVGGLAVFAAGSVIAALS-------DSIWGIILGRAL----- 110
Cdd:cd06176 36 TLVGLLIALHYLVA-PLRVWIGHRSDTHPlrgyrRTPYIWLGMLLLALGLALAPFAalllagaAFWLGLALAVLAfllyg 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 111 QGSGAIAAAVMALLSDLTREQNRTKAMAFIgvsfgitfAIAMVLGPIITHKLGLHAL-----FWMIAILATTG-IALTIW 184
Cdd:cd06176 115 IGVGAAGTAFLALLADLTPEERRPRAVTVV--------WTMLILGIIVTAIVFGRLLdpyspERLIQVFQIVAlVALLLA 186
|
..
gi 446923700 185 VV 186
Cdd:cd06176 187 LL 188
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
20-183 |
5.44e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.21 E-value: 5.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 20 VFSLrmLGMF-MVLPVLTTYG-----MALQGASEALIGIAIGIYGLTQAVFQIPFGLL-SDRIGRKPLIVGGLAVFAAGS 92
Cdd:cd17490 198 FFSL--LAILqQMITFSTTFGftpliAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYC 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 93 VIAALSDSIWGIILGRALQG--SGAIAAAVMAL-LSDLTREQnRTKAMAFigvsFGITFAIAMVLGPI----ITHKLGLH 165
Cdd:cd17490 276 FLIPFAPNLTLLYLLQALNGfgTGILFPLLMSLsIEGVPAEQ-RSTAMGF----FQAIYALGMFLGPVlvgiISEAFGLQ 350
|
170
....*....|....*...
gi 446923700 166 ALFWMIAILATTGIALTI 183
Cdd:cd17490 351 TGFFVIGVIALLAAILSL 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
300-403 |
5.95e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 300 TQFWQLVVG--VQLFFVAFNLMEALlpSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAML 377
Cdd:cd17325 82 TSYWQLLLArfLQGLASAAVWPAAM--ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
90 100
....*....|....*....|....*.
gi 446923700 378 AAVWLAVASTMKEPPYVSSLRIEIPA 403
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSA 185
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
57-188 |
6.12e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 42.03 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 57 YGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGsgaIAAAVMALLSDLT------RE 130
Cdd:PRK10504 54 YVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQG---VGGAMMVPVGRLTvmkivpRE 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446923700 131 QnRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPN 188
Cdd:PRK10504 131 Q-YMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMPN 187
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
34-386 |
6.22e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.83 E-value: 6.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 34 VLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGS 113
Cdd:cd17353 24 VFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 114 GAIAAAVMALLSDLTR--EQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILAT---TGIALTI----- 183
Cdd:cd17353 104 IGAGIGYITPVSTAVKwfPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLiiiVIGAFLIrdppk 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 184 -WVVPNSSTHVLNRESGMVKGSFSKVLAEPR--LLKLNFGIMCLHILLMSTFVALPGQlADAGFPAAEhwkvylATMLIA 260
Cdd:cd17353 184 gWVPPGVDPLANNAENSPRDYTPREMLRTPTfwLLWLMFFLNATAGLMLIGQAKPIGQ-EFAGLDAGI------AALAVS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 261 FGSVV-----PFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGY 335
Cdd:cd17353 257 ILSIFngggrPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKN 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446923700 336 KGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVAS 386
Cdd:cd17353 337 AGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
44-186 |
7.27e-04 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 41.53 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQ--GSGAIAAAVM 121
Cdd:cd17479 234 GGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHafSNGALWWAVN 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446923700 122 ALLSDLTREQ-NRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWmiailaTTGIALTIWVV 186
Cdd:cd17479 314 SQVEFLASPGmERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQ------ACCVVLGLWLI 373
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
16-125 |
1.08e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 41.08 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 16 GLGTVFSLRMLGMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQ-IPFGLLSDRIGRKPLIVGGLAVFAAGSVI 94
Cdd:cd17388 210 GLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQaFVTGPIAKRLGEKRAILLGLAADALGFLL 289
|
90 100 110
....*....|....*....|....*....|..
gi 446923700 95 AALSDSIWGIILGRALQGSGAIAA-AVMALLS 125
Cdd:cd17388 290 LAFATQGWMVFPILILLALGGIAGpALQGLLS 321
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
278-413 |
1.11e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 278 KQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVqLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSL 357
Cdd:pfam07690 62 RRVLLIGLLLFALGLLLLLFASSLWLLLVLRV-LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLL 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446923700 358 GGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPANIAANEALKV 413
Cdd:pfam07690 141 GGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
27-185 |
1.42e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.91 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 27 GMFMVLPVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIW---- 102
Cdd:COG2270 253 GVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALafwi 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 103 -GIILGRALqgsGAIAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLG-LHALFWMIAILATTGIA 180
Cdd:COG2270 333 lGLLIGLVM---GGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGsQRLGILSLIVFFVIGLV 409
|
....*
gi 446923700 181 LTIWV 185
Cdd:COG2270 410 LLLRV 414
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
69-209 |
1.62e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.72 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 69 GLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAA--VMALLSDLTREQNRTKAMAFI--GVSF 144
Cdd:PRK11551 71 GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALpnLIALTSEAVGPRLRGTAVSLMycGVPF 150
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446923700 145 GitFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRESGMVKGSFSKVL 209
Cdd:PRK11551 151 G--GALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRAL 213
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
45-243 |
1.71e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 40.58 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 45 ASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVMA 122
Cdd:PRK15403 48 ADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSIcfIATVGYV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 123 LLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTH-VLNRESGMV 201
Cdd:PRK15403 128 TVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRgAVPFSAKSV 207
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 446923700 202 KGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLADAG 243
Cdd:PRK15403 208 LRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAG 249
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
44-175 |
2.07e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.32 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 44 GASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVM 121
Cdd:cd17393 231 GASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLsvVVPLAF 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446923700 122 ALLSDLTREqNRTKAMAFIGVsfgiTFAIAMVLGP----IITHKLGLHALFWMIAILA 175
Cdd:cd17393 311 SAAGALPGL-AAGIAVARVAT----LGYLGFLVGPpligFLADATGLRTAFLVVALLA 363
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
52-187 |
3.65e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 52 IAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALsdsiwGIILGRALQGSGAIAAAVMALL------- 124
Cdd:pfam00083 291 LVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGI-----VALLGVSKSDWAGIVAIVFIALfiaffam 365
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446923700 125 ----------SDLTREQNRTKAMAFIGVS-FGITFAIAMvLGPIITHKLGLHALFWMIAILATTGIALTIWVVP 187
Cdd:pfam00083 366 gwgpvpwvivSELFPLSVRSKAMALATAAnWLANFLIGF-LFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVP 438
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
39-377 |
3.78e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.37 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 39 GMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIvggLAVFAAGSVIAALS------DSIWGIILGRALQG 112
Cdd:COG2270 43 ALGDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPF---LAFFTLLGVLATAAlffvapGGLWLGLLLFVLAN 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 113 SGAIAAAVM--ALLSDLTREQNRTK------AMAFIGVSFGITFAIAMVLGP----IITHKLGLHALFWMIAILATTGIA 180
Cdd:COG2270 120 IGFEGSLVFynAFLPDIATPEEIGRvsglgwALGYLGGVLLLLINLALFLKPeafgLPDAGEAVRISFLLTALWWLLFAL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 181 LTIWVVPNSSTHVLNRESGMVKGSFSKVLAEPRLLK--------------LNFGIMCLhILLMSTFVAlpgqlADAGFPA 246
Cdd:COG2270 200 PLFLFLPERPRPGPAPPRGAVRAGFRELRRTLRELRryrdllrfllayffYRDGVQTV-IAFAGIYAA-----GVLGFST 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 247 AEHWKVYLATMLIAFGSVvpfIIYAEVKRKM--KQVFVFCVGLIVVAEIVLW--NAQTQFWQLVVGVQLFFVAfnlMEAL 322
Cdd:COG2270 274 TELIVFGLLVQIVAALGA---LLFGRLDDRIgpKRVILVSLVIWIVVCLAAYflTTALAFWILGLLIGLVMGG---IQAL 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446923700 323 LPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQ-------GVFLAGAML 377
Cdd:COG2270 348 SRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQrlgilslIVFFVIGLV 409
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
58-189 |
4.50e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 4.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 58 GLTQAVFQIP-------FGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVMALLsdLTRE 130
Cdd:TIGR00898 130 DLTQSCFFVGvllgsfvFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV--LNTE 207
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446923700 131 QNRTKAMAFIGVSFGITFAIAMVLgpiithkLGLHALF-----WMIAILATTGI--ALTIWVVPNS 189
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVL-------LPLVAYFipdwrWLQLAVSLPTFlfFLLSWFVPES 266
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
46-189 |
4.52e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 39.09 E-value: 4.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 46 SEALIGIAIGiygltqAVFqipFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQG--SGAIAAAVMAL 123
Cdd:cd17359 43 SSALLGAAIG------ALF---AGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGlaVGGASALVPMY 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446923700 124 LSDLTREQNRTKAMAF--------IGVSFGITFAIAMVLGPIIthkLGLHALFWMIAILATTGIALTI--WVVPNS 189
Cdd:cd17359 114 IAEVAPAEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADW---LGAEGWRWMLGLEAIPAILFLLgmLFIPES 186
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
51-189 |
5.12e-03 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 38.94 E-value: 5.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 51 GIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVggLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAV-MALLSDLTR 129
Cdd:cd17387 39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMRISPWWYFAMISVSGIFSVTFSViFAYVADITT 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 130 EQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNS 189
Cdd:cd17387 117 EEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPES 176
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
32-189 |
5.43e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.27 E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 32 LPVLTTYgMALQGASEALIGIA--IG----------IYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSD 99
Cdd:pfam06609 51 LNVCATY-FVLQASASALPNILqdIGqsenqglfstLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTAN 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 100 SIWGIILGRALQGSGAIAAAVMAL-LSDLTreQNRTKAMAFIGVSfgITFAIAMVLGPIITHKLGLHA----LFWMIAIL 174
Cdd:pfam06609 130 KFNTLLAAMTLLGVAAGPAGASPLfIGELM--SNKTKFLGLLIVS--APTIAMNGAGPYFGQRLAIQGnwrwIFYIYIIM 205
|
170
....*....|....*.
gi 446923700 175 ATTGIAL-TIWVVPNS 189
Cdd:pfam06609 206 SAIAVLLiIIWYHPPS 221
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
14-385 |
5.77e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 38.71 E-value: 5.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 14 TWGLGTVFSLRML------GMFMVLpVLTTYGMALQGASEALIGIAIGIYGLTQAVFQIPFGLLSDRI-GRKPLIVGGLA 86
Cdd:cd17346 1 PKGLYTLFFTEMWerfsyyGMRAIL-ILYLTAQLGDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIGGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 87 VFAAGSVIAALSD-SIWGIILGRAL--QGSGAIAAAVMALLSDLTREQNRTKAMAF----IGVSFGITFAiamvlgPIIT 159
Cdd:cd17346 80 LMALGYLLLALSPfSVSMLYLGLALiiVGNGLFKPNISSLVGKLYDENDPRRDSGFsifyMGINLGAFLA------PLLC 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 160 HKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNResgmvkgsfSKVLAeprllklnFGIMCLHILL--------MST 231
Cdd:cd17346 154 GTLGDNYGYHYGFGLAAVGMLLGLLIFLLGRKKLLER---------KKMLA--------IIILFLFAVVfwaiyeqaGTS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 232 FVALPGQLADA---GFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQ---VFVFCVGLIVVA----------EIVL 295
Cdd:cd17346 217 LALFADENVDRllgGFTIPPSWFQSLNPLFIILLAPILAALWTKLGKRGKDpsiPTKFALGLLLLGlsfllmvlaaSFAG 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 296 WNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYstsqFLGVAIGGSLGGWIDGMFDGQGVFLAGA 375
Cdd:cd17346 297 GSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLW----FLASALGNILAGYLAGFYAQPKDPLASA 372
|
410
....*....|.
gi 446923700 376 -MLAAVWLAVA 385
Cdd:cd17346 373 lVYTDYFGLIG 383
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
65-187 |
5.87e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 5.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 65 QIPFGLLSDRIGRKPLIVGGL---AVFAAGSVIAALSDSIWGIILgRALQG--SGAIAAAVMALLSDLTR--EQNRTKAM 137
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSIlitALLTLLTPLAARGGYGALIVL-RILQGlaQGVTFPAMHALWAKWAPplERSRLTSI 151
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446923700 138 AFIGVSFGItfAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVP 187
Cdd:cd17318 152 AYSGSQFGT--VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
51-171 |
6.68e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 38.64 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 51 GIAIGIYGLTQavfqipFGLLSDRIGRKPLIV---GGLAVFAAGSV-IAALSDSIWGIILGRALQGS----GAIAAAVMA 122
Cdd:cd17449 74 GFLVGLFSVTL------LGPWSDSVGRRPVLIlpsLGLALQAAVYLlVMYLQLHVAYFLIGRILSGLlgdfNGILAGCFA 147
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446923700 123 LLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMI 171
Cdd:cd17449 148 YVADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLV 196
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
8-187 |
7.93e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 38.32 E-value: 7.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 8 PGERRATWGLGTVFSLRMLGMFMVLP---VLTTyGMALQG---------------------ASEALIGIAIGIYGLTQAV 63
Cdd:cd17315 151 PGWWRLMFALAAVPALLQLLLMFFLPesrALLV-GVGLQLlqqltginavmyyaptifksaGGGTASILASIIVGVVNLL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 64 FQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSdsiwgIILGRALQGSGAIAAAVMA----------------LLSDL 127
Cdd:cd17315 230 ATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIA-----FLLPALAKAAGWLALLGILlyiaafamgagpvpwlLLSEI 304
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446923700 128 TREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVP 187
Cdd:cd17315 305 FPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVP 364
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
69-114 |
8.15e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.41 E-value: 8.15e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 446923700 69 GLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSG 114
Cdd:cd17360 56 GWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLG 101
|
|
| |
