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Conserved domains on  [gi|446929925|ref|WP_001007181|]
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MULTISPECIES: GntR family transcriptional regulator [Streptococcus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-229 1.47e-43

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 146.93  E-value: 1.47e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925   1 MAIPKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRARKH----KL 76
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEyplsRL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925  77 VEFSDVEIFETKDDKVTVLSIERGNKLEYL-DKLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYInANYPNLDY-YS 154
Cdd:COG2188   82 TSFTEELRARGREPSTRVLSAERVPADEEVaEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALF-PGLLEEDLeTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446929925 155 SIYTRF--KLDYRIHMSDEHFEeineiAFPTPEHAASVLGIDTQFPTVFQTKTTKLeATGQVLAYSETYKRADYYKI 229
Cdd:COG2188  161 SLYELLeeRYGLRITRAEQRIE-----AVLADAEEAELLGVPPGAPVLVIERVTYD-ADGRPVEYSRSYYRGDRYRF 231
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-229 1.47e-43

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 146.93  E-value: 1.47e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925   1 MAIPKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRARKH----KL 76
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEyplsRL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925  77 VEFSDVEIFETKDDKVTVLSIERGNKLEYL-DKLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYInANYPNLDY-YS 154
Cdd:COG2188   82 TSFTEELRARGREPSTRVLSAERVPADEEVaEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALF-PGLLEEDLeTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446929925 155 SIYTRF--KLDYRIHMSDEHFEeineiAFPTPEHAASVLGIDTQFPTVFQTKTTKLeATGQVLAYSETYKRADYYKI 229
Cdd:COG2188  161 SLYELLeeRYGLRITRAEQRIE-----AVLADAEEAELLGVPPGAPVLVIERVTYD-ADGRPVEYSRSYYRGDRYRF 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 1.64e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.43  E-value: 1.64e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446929925   4 PKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVS 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
4-166 2.00e-18

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 81.03  E-value: 2.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925   4 PKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFV-SRARKHKLVE---F 79
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVqSQKVENALLTvsgF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925  80 SDVEIFETKDDKVTVLSIERGNKLEYLDKLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYinanYPNLDYY----SS 155
Cdd:PRK11402  89 TDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSR----YPDFDEIyvegSS 164

                        170
                 ....*....|.
gi 446929925 156 IYTRFKLDYRI 166
Cdd:PRK11402 165 TYQLFQERFDT 175
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 5-68 1.72e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.80  E-value: 1.72e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446929925    5 KYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFV 68
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 88-228 1.06e-16

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 74.25  E-value: 1.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925    88 KDDKVTVLSIERGNKLEYL-DKLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYInANYPNLDYYSSIYTRFKLDYRI 166
Cdd:smart00866   4 RKPTTKVLSFERVPADEELaEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALF-PGLLEEDLSGSLYEYLEERLGL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446929925   167 HMSDEHFEEINEIAFPTPEHAASVLGIDTQFPTVFQTKTTKLEAtGQVLAYSETYKRADYYK 228
Cdd:smart00866  83 KIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDD-GRPVEYSRSYYRGDRFR 143
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 5-124 2.02e-11

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 61.61  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925    5 KYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRARKHK-----LVEF 79
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEfpisgITSF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446929925   80 SDVEIFETKDDKVTVLSIERGNKLEYL--DKLGLRGDQFYYKIERIR 124
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLPETlaQLTGLEEGSLIWRIKRVR 127
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
1-229 1.47e-43

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 146.93  E-value: 1.47e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925   1 MAIPKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRARKH----KL 76
Cdd:COG2188    2 SPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEyplsRL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925  77 VEFSDVEIFETKDDKVTVLSIERGNKLEYL-DKLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYInANYPNLDY-YS 154
Cdd:COG2188   82 TSFTEELRARGREPSTRVLSAERVPADEEVaEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALF-PGLLEEDLeTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446929925 155 SIYTRF--KLDYRIHMSDEHFEeineiAFPTPEHAASVLGIDTQFPTVFQTKTTKLeATGQVLAYSETYKRADYYKI 229
Cdd:COG2188  161 SLYELLeeRYGLRITRAEQRIE-----AVLADAEEAELLGVPPGAPVLVIERVTYD-ADGRPVEYSRSYYRGDRYRF 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-69 1.64e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.43  E-value: 1.64e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446929925   4 PKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVS 69
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
4-166 2.00e-18

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 81.03  E-value: 2.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925   4 PKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFV-SRARKHKLVE---F 79
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVqSQKVENALLTvsgF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925  80 SDVEIFETKDDKVTVLSIERGNKLEYLDKLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYinanYPNLDYY----SS 155
Cdd:PRK11402  89 TDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSR----YPDFDEIyvegSS 164

                        170
                 ....*....|.
gi 446929925 156 IYTRFKLDYRI 166
Cdd:PRK11402 165 TYQLFQERFDT 175
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 5-68 1.72e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 73.80  E-value: 1.72e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446929925    5 KYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFV 68
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 88-228 1.06e-16

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 74.25  E-value: 1.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925    88 KDDKVTVLSIERGNKLEYL-DKLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYInANYPNLDYYSSIYTRFKLDYRI 166
Cdd:smart00866   4 RKPTTKVLSFERVPADEELaEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALF-PGLLEEDLSGSLYEYLEERLGL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446929925   167 HMSDEHFEEINEIAFPTPEHAASVLGIDTQFPTVFQTKTTKLEAtGQVLAYSETYKRADYYK 228
Cdd:smart00866  83 KIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDD-GRPVEYSRSYYRGDRFR 143
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-68 3.86e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 70.30  E-value: 3.86e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925     9 IKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFV 68
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-78 7.68e-16

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 70.98  E-value: 7.68e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446929925   3 IPKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRARKHKLVE 78
Cdd:COG1725    9 VPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEE 84
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
6-78 3.91e-13

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 66.50  E-value: 3.91e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446929925   6 YQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSsITVVR-ALNDLAKDGYIVRQQGKGTFVSRARKHKLVE 78
Cdd:COG2186    9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVS-RTTVReALRALEALGLVEVRQGGGTFVREPSPWALLD 81
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-72 5.67e-13

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 67.55  E-value: 5.67e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446929925   1 MAIPKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRAR 72
Cdd:COG1167    9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-72 6.35e-12

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 63.03  E-value: 6.35e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446929925   4 PKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRAR 72
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 5-124 2.02e-11

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 61.61  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925    5 KYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRARKHK-----LVEF 79
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEfpisgITSF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 446929925   80 SDVEIFETKDDKVTVLSIERGNKLEYL--DKLGLRGDQFYYKIERIR 124
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLPETlaQLTGLEEGSLIWRIKRVR 127
PRK09764 PRK09764
GntR family transcriptional regulator;
2-238 1.48e-10

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 59.46  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925   2 AIPKYQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSRARK----HKLV 77
Cdd:PRK09764   3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVnydiFQLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925  78 EF------------SDVEIFETK--DDKV-TVLSIERGNKLEYldklglrgdqfyykIERIRQTNDVTYIYHTSYIPEqy 142
Cdd:PRK09764  83 SFdeklsdrhvdthSEVLIFEVIpaDDFLqQQLQITAQDRVWH--------------VKRVRYRKQKPMALEETWMPL-- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925 143 inANYPNLDYysSIYTRFKLDY----RIHMSDEHFEEIneIAFPTPEHAASVLGIDTQFPTVfQTKTTKLEATGQVLAYS 218
Cdd:PRK09764 147 --ALFPDLTW--QVMENSKYHFieevKKMVIDRSEQEI--IPLMPTEEMSRLLNISQTKPIL-EKVSRGYLVDGRVFEYS 219

                        250       260
                 ....*....|....*....|
gi 446929925 219 ETYKRADYYKIKFISCNRGH 238
Cdd:PRK09764 220 RNAFNTDDYKFTLIAQRKSS 239
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
11-70 2.61e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 58.40  E-value: 2.61e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446929925  11 DELKNKIISGQFASGDKFyTEAELIAMYDVsSITVVR-ALNDLAKDGYIVRQQGKGTFVSR 70
Cdd:COG1802   18 EALREAILSGELPPGERL-SEAELAERLGV-SRTPVReALRRLEAEGLVEIRPNRGARVAP 76
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 108-228 5.33e-10

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 56.07  E-value: 5.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925  108 KLGLRGDQFYYKIERIRQTNDVTYIYHTSYIPEQYInanyPNLDYY----SSIYTRFKLDYRIHMSdeHFEEINEIAFPT 183
Cdd:pfam07702  25 ALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELV----PDLLEEdleeGSLYDYLEERYGLPIT--RAEQTIEAVLAD 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 446929925  184 PEhAASVLGIDTQFPtVFQTKTTKLEATGQVLAYSETYKRADYYK 228
Cdd:pfam07702  99 AE-EAELLGISPGAP-VLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
9-69 4.55e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 43.47  E-value: 4.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446929925   9 IKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVS 69
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQ 75
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 5-68 1.30e-04

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 42.07  E-value: 1.30e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446929925   5 KYQYIKDELKNKIiSGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFV 68
Cdd:PRK10079  13 RYQEIAAKLEQEL-RQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 6-70 3.61e-04

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 40.78  E-value: 3.61e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446929925   6 YQYIKDELKNKIISGQFASGDKFYTEAELIAMYDVSSITVVRALNDLAKDGYIVRQQGKGTFVSR 70
Cdd:PRK03837  15 SEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSR 79
PRK11523 PRK11523
transcriptional regulator ExuR;
6-83 3.41e-03

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 37.90  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446929925   6 YQYIKDELKNKIISGQFASGDKFYTEaELIAMYDVSSITVVR-ALNDLAKDGYIVRQQGKGTFV-SRARKHKLVEFSDVE 83
Cdd:PRK11523  10 YQQLAAELKERIEQGVYLVGDKLPAE-RFIADEKNVSRTVVReAIIMLEVEGYVEVRKGSGIHVvSNQPRHQQAADNNME 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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