(2,3-dihydroxybenzoyl)adenylate synthase catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate via a reversible ATP-dependent pyrophosphate exchange reactions to yield the acyladenylate intermediate (2,3-dihydroxybenzoyl)adenylate, such as in the biosynthesis of the siderophore enterobactin| cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
224-283
6.62e-09
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.
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Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 51.41 E-value: 6.62e-09
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
2-203
6.08e-122
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.
Pssm-ID: 238495 Cd Length: 203 Bit Score: 347.40 E-value: 6.08e-122
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
224-283
6.62e-09
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.
Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 51.41 E-value: 6.62e-09
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
2-203
6.08e-122
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.
Pssm-ID: 238495 Cd Length: 203 Bit Score: 347.40 E-value: 6.08e-122
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
32-192
8.69e-50
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.
Pssm-ID: 238245 [Multi-domain] Cd Length: 161 Bit Score: 162.44 E-value: 8.69e-50
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
31-201
5.67e-38
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440946 [Multi-domain] Cd Length: 169 Bit Score: 131.95 E-value: 5.67e-38
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
32-207
3.44e-15
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.
Pssm-ID: 238494 [Multi-domain] Cd Length: 157 Bit Score: 71.47 E-value: 3.44e-15
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
32-186
1.52e-14
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.
Pssm-ID: 238496 [Multi-domain] Cd Length: 155 Bit Score: 69.54 E-value: 1.52e-14
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
33-203
9.10e-14
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.
Pssm-ID: 238497 [Multi-domain] Cd Length: 179 Bit Score: 68.20 E-value: 9.10e-14
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
224-283
6.62e-09
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.
Pssm-ID: 425746 [Multi-domain] Cd Length: 62 Bit Score: 51.41 E-value: 6.62e-09
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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