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Conserved domains on  [gi|446930474|ref|WP_001007730|]
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MULTISPECIES: YheV family putative zinc ribbon protein [Enterobacteriaceae]

Protein Classification

YheV family putative metal-binding protein( domain architecture ID 10007521)

YheV family putative metal-binding protein is a DUF2387 domain-containing protein; similar to Escherichia coli protein YheV

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3529 COG3529
Predicted nucleic-acid-binding protein, contains Zn-ribbon domain [General function prediction ...
 1-66 5.60e-32

Predicted nucleic-acid-binding protein, contains Zn-ribbon domain [General function prediction only];


:

Pssm-ID: 442751  Cd Length: 67  Bit Score: 104.98  E-value: 5.60e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446930474  1 MAIRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGHQMREADKEARDHVRKDEQVIGIFHPD 66
Cdd:COG3529   2 TKMKKRFIAGAVCPKCQAMDTLVLWRENGVEVRECVSCGYTETQPDEEVEAATEAEEQVIGIFKPE 67
 
Name Accession Description Interval E-value
COG3529 COG3529
Predicted nucleic-acid-binding protein, contains Zn-ribbon domain [General function prediction ...
 1-66 5.60e-32

Predicted nucleic-acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 442751  Cd Length: 67  Bit Score: 104.98  E-value: 5.60e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446930474  1 MAIRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGHQMREADKEARDHVRKDEQVIGIFHPD 66
Cdd:COG3529   2 TKMKKRFIAGAVCPKCQAMDTLVLWRENGVEVRECVSCGYTETQPDEEVEAATEAEEQVIGIFKPE 67
TIGR02443 TIGR02443
conserved hypothetical metal-binding protein; Members of this family are small proteins, about ...
 2-60 4.41e-31

conserved hypothetical metal-binding protein; Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various Proteobacteria.


Pssm-ID: 131496  Cd Length: 59  Bit Score: 102.52  E-value: 4.41e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446930474   2 AIRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGHQMREADKEARDHVRKDEQVI 60
Cdd:TIGR02443  1 KIKKRFIAGAVCPACSAQDTLAMWKENNIELVECVECGYQEQQKDQSVSVHERANEQVI 59
DUF2387 pfam09526
Probable metal-binding protein (DUF2387); Members of this family are small proteins, about 70 ...
 3-63 4.74e-17

Probable metal-binding protein (DUF2387); Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.


Pssm-ID: 430664  Cd Length: 72  Bit Score: 67.52  E-value: 4.74e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446930474   3 IRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGH--QMREAD--KEARDHVRKDE-------QVIGIF 63
Cdd:pfam09526  1 TKKRFIAGAVCPACSEMDKLVMWKEDGVPHRECVACGFsdTLNEKSvpKELGTRVNVSApaadpqvQTVQFF 72
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 29-66 5.88e-03

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 32.70  E-value: 5.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446930474  29 NIDIVECVKCGHQMREADKEARDHVRKDEQVIGIFHPD 66
Cdd:cd00296  110 SLDRVRCTSCGKEYPRDEVLEREKPPRCPKCGGLLRPD 147
 
Name Accession Description Interval E-value
COG3529 COG3529
Predicted nucleic-acid-binding protein, contains Zn-ribbon domain [General function prediction ...
 1-66 5.60e-32

Predicted nucleic-acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 442751  Cd Length: 67  Bit Score: 104.98  E-value: 5.60e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446930474  1 MAIRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGHQMREADKEARDHVRKDEQVIGIFHPD 66
Cdd:COG3529   2 TKMKKRFIAGAVCPKCQAMDTLVLWRENGVEVRECVSCGYTETQPDEEVEAATEAEEQVIGIFKPE 67
TIGR02443 TIGR02443
conserved hypothetical metal-binding protein; Members of this family are small proteins, about ...
 2-60 4.41e-31

conserved hypothetical metal-binding protein; Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various Proteobacteria.


Pssm-ID: 131496  Cd Length: 59  Bit Score: 102.52  E-value: 4.41e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446930474   2 AIRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGHQMREADKEARDHVRKDEQVI 60
Cdd:TIGR02443  1 KIKKRFIAGAVCPACSAQDTLAMWKENNIELVECVECGYQEQQKDQSVSVHERANEQVI 59
DUF2387 pfam09526
Probable metal-binding protein (DUF2387); Members of this family are small proteins, about 70 ...
 3-63 4.74e-17

Probable metal-binding protein (DUF2387); Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.


Pssm-ID: 430664  Cd Length: 72  Bit Score: 67.52  E-value: 4.74e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446930474   3 IRKRFIAGAKCPACQAQDSMAMWRENNIDIVECVKCGH--QMREAD--KEARDHVRKDE-------QVIGIF 63
Cdd:pfam09526  1 TKKRFIAGAVCPACSEMDKLVMWKEDGVPHRECVACGFsdTLNEKSvpKELGTRVNVSApaadpqvQTVQFF 72
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 29-66 5.88e-03

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 32.70  E-value: 5.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446930474  29 NIDIVECVKCGHQMREADKEARDHVRKDEQVIGIFHPD 66
Cdd:cd00296  110 SLDRVRCTSCGKEYPRDEVLEREKPPRCPKCGGLLRPD 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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