|
Name |
Accession |
Description |
Interval |
E-value |
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
7-414 |
0e+00 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 534.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 7 NQHVLNNLLYILSSIFIFYFIYDSGRYVKK-YKKLLIILCTSIPLILCMRYPIYMDESCIHDLRQIPVIIGTLYGGFPVG 85
Cdd:COG5806 1 IKDLLLNLLFILLPIFIYQIFWEDRRRNKPvKNRMLIGVLSSIAIILCMTFPIHITDGFIFDLRQVPIILGTLYGGWRVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 86 IILLTILLIIRFSFYGFSM-LTMLVYGIMFIITAFASAKFNTYNRKIKVAYAMFLTFFLAIFTTVIVLT-LSDFEVNNLY 163
Cdd:COG5806 81 LFLFLILLLYRFYLGGEGVfVTLLVYTVILILPLLLRRKFHRLSRKGKIVLAILLSFLSALLLLLLAIIfIADISELLDF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 164 IIYFIILPTVLMLFVVYFNEVLKDAVCMRSKLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRDEYI 243
Cdd:COG5806 161 ILYFIIIQLLAMLIAVYLIENLIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 244 KHILEELHHAQGIIDDYLTFAKPASEKLDEISVEQELNRVINMILPLCNMNTIHITKDFS-TATIVGNKQHFQQCFLNLL 322
Cdd:COG5806 241 RIALEELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEpGLYIEGDRQKLQQCLINII 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 323 KNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVIN 402
Cdd:COG5806 321 KNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVG 400
|
410
....*....|..
gi 446935012 403 KGTTLTITFPKC 414
Cdd:COG5806 401 KGTTFTITLPLA 412
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
195-413 |
7.82e-70 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 228.85 E-value: 7.82e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 195 LIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKtpnLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPASEKLDEI 274
Cdd:COG5805 278 MARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQ---PGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKE 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 275 SVEQELNRVINMILPLCNMNTIHITKDFS--TATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIED 352
Cdd:COG5805 355 NINELIQDVVTLLETEAILHNIQIRLELLdeDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVID 434
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446935012 353 SGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:COG5805 435 EGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
191-418 |
9.84e-65 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 211.24 E-value: 9.84e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 191 MRSKLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKTpNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPASEK 270
Cdd:COG3852 122 LERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLER-ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPE 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 271 LDEISVEQELNRVINMILPLCNmNTIHITKDF--STATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSIS------ 342
Cdd:COG3852 201 REPVNLHEVLERVLELLRAEAP-KNIRIVRDYdpSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqvtlg 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 343 ----NNKVIIRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPKCNKNS 418
Cdd:COG3852 280 glrpRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
194-413 |
1.75e-64 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 214.45 E-value: 1.75e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 194 KLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKtPNLTPESRdEYIKHILEELHHAQGIIDDYLTFAKPASEKLDE 273
Cdd:COG5809 260 LLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLK-DTIDEEQK-TYLDIMLSELDRIESIISEFLVLAKPQAIKYEP 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 274 ISVEQELNRVINMILPLCNMNTIHITKDFS--TATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNIS-SSISNNKVIIRI 350
Cdd:COG5809 338 KDLNTLIEEVIPLLQPQALLKNVQIELELEddIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIEtKAEDDDKVVISV 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446935012 351 EDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:COG5809 418 TDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
194-412 |
7.64e-64 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 209.26 E-value: 7.64e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 194 KLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKTPNLTPEsRDEYIKHILEELHHAQGIIDDYLTFAKPASEKLDE 273
Cdd:COG5807 137 KLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSE-REEYFNIIISEIDRINTIITELLVLSKPKKFNFKK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 274 ISVEQELNRVINMILPLCNMNTIHITKDFSTATIV--GNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIE 351
Cdd:COG5807 216 LNLNDVLEDVIALLSTEAILKNISIKYDLADDEPVinGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVK 295
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446935012 352 DSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:COG5807 296 DEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
191-412 |
3.00e-61 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 202.34 E-value: 3.00e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 191 MRSKLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLK---TPNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPA 267
Cdd:COG4191 129 LQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRrrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 268 SEKLDEISVEQELNRVINMILPLCNMNTIHITKDFSTA--TIVGNKQHFQQCFLNLLKNGIEAMPNG--GTLNISSSISN 343
Cdd:COG4191 209 EEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDlpPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREG 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446935012 344 NKVIIRIEDSGIGMSQEQINRFGEPYFSTK--TKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:COG4191 289 DYVVISVRDNGPGIPPEVLERIFEPFFTTKpvGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
193-413 |
2.32e-59 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 199.42 E-value: 2.32e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 193 SKLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLK---TPNLT--PESRDEYIKHILEELHHAQGIIDDYLTFAKPA 267
Cdd:COG5000 190 TELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRrklADKLEedREDLERALDTIIRQVDRLKRIVDEFLDFARLP 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 268 SEKLDEISVEQELNRVINMILPLCNMNTIHITKDFSTA--TIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNK 345
Cdd:COG5000 270 EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDlpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGR 349
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446935012 346 VIIRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:COG5000 350 VRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
96-413 |
3.17e-55 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 185.88 E-value: 3.17e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 96 RFSFYGFSMLTMLVYGIMFIITAFASAKFNTYNRKIKVAYAMFLTFFLAIFTTVIVLTLSDFEVNNLYIIYFIILPTVLM 175
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 176 LFVVYFNEVLKDAVCMRSKLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKtpNLTPESRDEYIKHILEELHHAQG 255
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLL--EELDEEQREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 256 IIDDYLTFAKPASEKLD----EISVEQELNRVINMILPLCNMNTIHITKDFS--TATIVGNKQHFQQCFLNLLKNGIEAM 329
Cdd:COG0642 160 LINDLLDLSRLEAGKLElepePVDLAELLEEVVELFRPLAEEKGIELELDLPddLPTVRGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 330 PNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTK----TKGTGLGTMVAVKIIETMQGSLKIRSVINKGT 405
Cdd:COG0642 240 PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDpsrrGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*...
gi 446935012 406 TLTITFPK 413
Cdd:COG0642 320 TFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
191-413 |
8.38e-50 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 168.55 E-value: 8.38e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 191 MRSKLIKMEKMEivSQLAASISHEVRNPLTVVKGFTQLLK-TPNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPASE 269
Cdd:COG2205 5 ALEELEELERLK--SEFLANVSHELRTPLTSILGAAELLLdEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 270 KL----DEISVEQELNRVINMILPLCNMNTIHITKDF--STATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISN 343
Cdd:COG2205 83 KLslelEPVDLAELLEEAVEELRPLAEEKGIRLELDLppELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446935012 344 NKVIIRIEDSGIGMSQEQINRFGEPYF----STKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
193-413 |
6.03e-46 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 163.18 E-value: 6.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 193 SKLIKMEKMEivSQLAASISHEVRNPLTVVKGFTQLLKT-PNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPASEKL 271
Cdd:COG5002 156 TELERLEQMR--REFVANVSHELRTPLTSIRGYLELLLDgAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGEL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 272 ----DEISVEQELNRVINMILPLCNMNTIHITKDFST--ATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNK 345
Cdd:COG5002 234 klekEPVDLAELLEEVVEELRPLAEEKGIELELDLPEdpLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQ 313
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446935012 346 VIIRIEDSGIGMSQEQINRFGEPYF------STKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:COG5002 314 VRISVRDTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
191-412 |
2.11e-40 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 152.04 E-value: 2.11e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 191 MRSKLIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRdEYIKHILEELHHAQGIIDDYLTFAKPASEK 270
Cdd:PRK11360 377 LQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQ-EYLSVVLREVDRLNKVIDQLLEFSRPRESQ 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 271 LDEISVEQELNRVINMILPLCNMNTIHITKDFSTA--TIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNIS-SSISNNKVI 347
Cdd:PRK11360 456 WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNElpPIWADPELLKQVLLNILINAVQAISARGKIRIRtWQYSDGQVA 535
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446935012 348 IRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK11360 536 VSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
140-412 |
5.07e-32 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 126.44 E-value: 5.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 140 TFFLAIFTTVIVLTLSDfEVNNLYIIYF----IILPTVLMLFvvYFNEVLKDAVCMRSKLIKMEKMEIVSQLAASISHEV 215
Cdd:PRK10364 172 AIFIAFDASNLVSAQAR-EQRNTLIILFalatVLLASLLAFF--WYRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 216 RNPLTVVKGFTQLL--KTPnltPESRDEYIKHIL-EELHHAQGIIDDYLTFAKPASEKLDEISVEQELNRVINMILPLCN 292
Cdd:PRK10364 249 RNPLSSIKGLAKYFaeRAP---AGGEAHQLAQVMaKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDAN 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 293 MNTIHI--TKDFSTATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYF 370
Cdd:PRK10364 326 SREIQLrfTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF 405
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446935012 371 STKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK10364 406 TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| 5TM-5TMR_LYT |
pfam07694 |
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ... |
21-178 |
1.24e-28 |
|
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).
Pssm-ID: 429599 Cd Length: 170 Bit Score: 110.35 E-value: 1.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 21 IFIFYFIYDSGRYvKKYKKLLIILCTSIPLILCMRYPIYMDESCIHDLRQIPVIIGTLYGGFPVGIILLTILLIIRFSFY 100
Cdd:pfam07694 1 IPLFRRLLSKRRL-RLKDKVLLGLIFGLFSILGTYTGIEIEPGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446935012 101 GFSMLTMLVYGIM-FIITAFASAKFNTYNRKIKVAYAMFLTFFLAIFTTVIVLTLSDFEVNNLYIIYFIILPTVLMLFV 178
Cdd:pfam07694 80 GFTALACGISTILaGLIAGLLHRRLKRRRRLISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNSL 158
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
199-412 |
1.13e-27 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 115.93 E-value: 1.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 199 EKMEIVSQLAASISHEVRNPLTVVKGFTQLLKTpNLTPESR-DEYIKHILEELHHAQGIIDDYLTFakpaSEKLDEISVE 277
Cdd:PRK13837 445 RRLEAVGTLASGIAHNFNNILGAILGYAEMALN-KLARHSRaARYIDEIISAGARARLIIDQILAF----GRKGERNTKP 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 278 QELNRVINMILPLCNMNTI-HITKDFS----TATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNK------- 345
Cdd:PRK13837 520 FDLSELVTEIAPLLRVSLPpGVELDFDqdqePAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRapkvlsh 599
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446935012 346 --------VIIRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK13837 600 gvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
206-413 |
2.73e-26 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 110.65 E-value: 2.73e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 206 QLAASISHEVRNPLTVVKGFTQLLKT---PNLTPESRdEYIKHILEELHHAQGIIDDYLTFAKPASEKLD--EISVEQEL 280
Cdd:COG4251 284 QFAYVASHDLREPLRKISGFSQLLEEdygDKLDEEGR-EYLERIRDAAERMQALIDDLLAYSRVGRQELEfePVDLNELL 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 281 NRVINMILPLCNMNTIHITKDfSTATIVGNKQHFQQCFLNLLKNGIEAMPNG--GTLNISSSISNNKVIIRIEDSGIGMS 358
Cdd:COG4251 363 EEVLEDLEPRIEERGAEIEVG-PLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGID 441
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446935012 359 QEQINR-FGepYF-----STKTKGTGLG-TMVAvKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:COG4251 442 PEYAEKiFE--IFqrlhsRDEYEGTGIGlAIVK-KIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
309-414 |
3.63e-26 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 101.57 E-value: 3.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 309 GNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTK-----TKGTGLGTMV 383
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 446935012 384 AVKIIETMQGSLKIRSVINKGTTLTITFPKC 414
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
309-412 |
4.01e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 90.51 E-value: 4.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 309 GNKQHFQQCFLNLLKNGIEAMPNGGTLNISssIS-NNKVIIRIEDSGIGMSQEQINRFGEPYFS---TKTKGTGLGTMVA 384
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT--LSeGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*...
gi 446935012 385 VKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-412 |
9.16e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 89.40 E-value: 9.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 316 QCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKT--KGTGLGTMVAVKIIETMQG 393
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQKHGG 85
|
90
....*....|....*....
gi 446935012 394 SLKIRSVINKGTTLTITFP 412
Cdd:cd16943 86 TIRVASVPGGGTRFTIILP 104
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
209-412 |
8.19e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 95.09 E-value: 8.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 209 ASISHEVRNPLTVVKGFTQLLKTPNLTPESRDeyikhILEELHHAQ----GIIDDYLTFAKPASEKLdeisveqELNRVI 284
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQNTPLTAEQMD-----LADTARQCTlsllAIINNLLDFSRIESGQM-------TLSLEE 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 285 NMILPLCN--MNTIH---ITKDFSTATIVGnkQHF-----------QQCFLNLLKNGIEAMPNGGtlnISSSI--SNNKV 346
Cdd:PRK15347 471 TALLPLLDqaMLTIQgpaQSKSLTLRTFVG--AHVplylhldslrlRQILVNLLGNAVKFTETGG---IRLRVkrHEQQL 545
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446935012 347 IIRIEDSGIGMSQEQINRFGEPYFSTKT--KGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK15347 546 CFTVEDTGCGIDIQQQQQIFTPFYQADThsQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
314-412 |
8.10e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 84.35 E-value: 8.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 314 FQQCFLNLLKNGIEAMPNGGTLNISSS---------------ISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKT--KG 376
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSnqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 446935012 377 TGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
203-412 |
1.31e-18 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 88.37 E-value: 1.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 203 IVSQLAASISHEVRNPLTVVKGFT-QLLKTPnLTPESRDeYIKHILEELHHAQGIIDDYLTFAKPASEK--LDEI--SVE 277
Cdd:PRK11107 292 IKSEFLANMSHELRTPLNGVIGFTrQTLKTP-LTPTQRD-YLQTIERSANNLLAIINDILDFSKLEAGKlvLENIpfSLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 278 QELNRVINMI--------LPLcnmnTIHITKDFStATIVGNKQHFQQCFLNLLKNGIEAMPNGgTLNISS---SISNNKV 346
Cdd:PRK11107 370 ETLDEVVTLLahsahekgLEL----TLNIDPDVP-DNVIGDPLRLQQIITNLVGNAIKFTESG-NIDILVelrALSNTKV 443
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 347 IIRIE--DSGIGMSQEQ--------------INR-FGepyfstktkGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTI 409
Cdd:PRK11107 444 QLEVQirDTGIGISERQqsqlfqafrqadasISRrHG---------GTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWF 514
|
...
gi 446935012 410 TFP 412
Cdd:PRK11107 515 HLP 517
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-412 |
4.61e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.98 E-value: 4.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 315 QQCFLNLLKNGIEAM----PNGGTLNISSSISNNK-VIIRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIE 389
Cdd:cd16920 2 QQVLINLVRNGIEAMseggCERRELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIE 81
|
90 100
....*....|....*....|...
gi 446935012 390 TMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16920 82 AHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
195-412 |
1.45e-17 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 84.72 E-value: 1.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 195 LIKMEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKT----PNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKpaSEK 270
Cdd:PRK13557 154 LRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAalshPDADRGRMARSVENIRAAAERAATLTQQLLAFAR--KQR 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 271 LDeisveqelNRVIN---MILPLCNM--NTI--HITKDFSTATIVGNKQ----HFQQCFLNLLKNGIEAMPNGGTLNISS 339
Cdd:PRK13557 232 LE--------GRVLNlngLVSGMGELaeRTLgdAVTIETDLAPDLWNCRidptQAEVALLNVLINARDAMPEGGRVTIRT 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 340 ---SISNNK------------VIIRIEDSGIGMSQEQINRFGEPYFSTKT--KGTGLG-TMVA--VKiietmQ--GSLKI 397
Cdd:PRK13557 304 rnvEIEDEDlamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGlSMVYgfAK-----QsgGAVRI 378
|
250
....*....|....*
gi 446935012 398 RSVINKGTTLTITFP 412
Cdd:PRK13557 379 YSEVGEGTTVRLYFP 393
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
205-412 |
5.71e-17 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 83.63 E-value: 5.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 205 SQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPASeklDEISVEQELNRVI 284
Cdd:PRK09959 713 SQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIES---GNYQLQPQWVDIP 789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 285 NMILPLC-NMNTIHITKDFSTAT---------IVGNKQHFQQCFLNLLKNGIEaMPNGGTLNISSS---ISNNKVIIR-- 349
Cdd:PRK09959 790 TLVQNTChSFGAIAASKSIALSCsstfpdhylVKIDPQAFKQVLSNLLSNALK-FTTEGAVKITTSlghIDDNHAVIKmt 868
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446935012 350 IEDSGIGMSQEQ----INRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK09959 869 IMDSGSGLSQEEqqqlFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
191-412 |
6.83e-17 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 82.81 E-value: 6.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 191 MRSKLIKMEKMEIVSQLAASISHEVRNPLTVVKG--FTQLLKTPNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPAS 268
Cdd:COG4192 420 TQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMylFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSD 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 269 EKLDEISVEQelnrVINMILPLCNMN------TIHITKDfstATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSIS 342
Cdd:COG4192 500 TPLQPVDLRQ----VIEQAWELVESRakpqqiTLHIPDD---LMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSN 572
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 343 NNKVIIRIEDSGIGMsqEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:COG4192 573 AENLRVAISDNGNGW--PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
191-413 |
2.11e-16 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 80.66 E-value: 2.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 191 MRSKLikmEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKTPnLTPESRDEYIKHILEELHHAQGIIDDYLTFAK----P 266
Cdd:PRK11100 246 MRVKL---EGKAYVEQYVQTLTHELKSPLAAIRGAAELLQED-PPPEDRARFTGNILTQSARLQQLIDRLLELARleqrQ 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 267 ASEKLDEISVEQELNRVINMILPLCNMNTIHITKDFSTATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKV 346
Cdd:PRK11100 322 ELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQV 401
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446935012 347 IIRIEDSGIGMSQEQINRFGEPYFS-----TKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:PRK11100 402 ALSVEDQGPGIPDYALPRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
201-265 |
4.13e-16 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 72.25 E-value: 4.13e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446935012 201 MEIVSQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRDEYIKHILEELHHAQGIIDDYLTFAK 265
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
198-413 |
8.35e-16 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 78.35 E-value: 8.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 198 MEKMEIVSQLAASISHEVRNPLTVVKGFTQLLKTpnltpESRDEYIKHILEELHHAQGIIDDYLTFAKPASEKLDEISVE 277
Cdd:COG3290 183 LEGVKELAEALRAQRHDFRNHLHTISGLLQLGEY-----DEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 278 QELNrvINMIL-PLCNMNTIHITkDFSTATIVGNkqhfqqcflnLLKNGIEAMPNGGTLN----ISSSISNNKVIIRIED 352
Cdd:COG3290 258 RERG--IDLTIdIDSDLPDLPLS-DTDLVTILGN----------LLDNAIEAVEKLPEEErrveLSIRDDGDELVIEVED 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446935012 353 SGIGMSQEQINRFGEPYFSTKTK-GTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:COG3290 325 SGPGIPEELLEKIFERGFSTKLGeGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
314-412 |
8.46e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 72.91 E-value: 8.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 314 FQQCFLNLLKNGIEAMPNGG-TLNIS---SSISNNKVIIRIEDSGIGMSQEQINRFGEPY------FSTKTKGTGLGTMV 383
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 446935012 384 AVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
205-265 |
1.60e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 70.67 E-value: 1.60e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446935012 205 SQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRdEYIKHILEELHHAQGIIDDYLTFAK 265
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQR-EYLETILREAERLLRLINDLLDLSR 62
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
205-269 |
4.54e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 69.55 E-value: 4.54e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446935012 205 SQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRdEYIKHILEELHHAQGIIDDYLTFAKPASE 269
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQR-EYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
209-413 |
8.50e-14 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 72.74 E-value: 8.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 209 ASISHEVRNPLTVVKGFTQLLKTPNLTPESRDEYIKHILEELHHAQGIIDDYLTFAK----PASEkLDEIS--------V 276
Cdd:PRK11006 209 ANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKieaaPTID-LNEKVdvpmmlrvL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 277 EQELNRVINmilplcNMNTIHITKDFSTAtIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIG 356
Cdd:PRK11006 288 EREAQTLSQ------GKHTITFEVDNSLK-VFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPG 360
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446935012 357 MSQEQINRFGEPYF------STKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:PRK11006 361 IAPEHIPRLTERFYrvdkarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
205-412 |
1.02e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 73.40 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 205 SQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRDeYIKHILEELHHAQGIIDDYLTF-AKPASEKLDEISVE-----Q 278
Cdd:PRK11466 445 SAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRD-DLRAITDSGESLLTILNDILDYsAIEAGGKNVSVSDEpfeprP 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 279 ELNRVINMILPLCNMNTIHITKDFST---ATIVGNKQHFQQCFLNLLKNGIEaMPNGGTLNISSSISNNKVIIRIEDSGI 355
Cdd:PRK11466 524 LLESTLQLMSGRVKGRPIRLATDIADdlpTALMGDPRRIRQVITNLLSNALR-FTDEGSIVLRSRTDGEQWLVEVEDSGC 602
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446935012 356 GMSQEQINRFGEPY--FSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK11466 603 GIDPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
316-412 |
1.48e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 66.41 E-value: 1.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 316 QCFLNLLKNG---IEAMPNG---GTLNISSSISNNKVIIrIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIE 389
Cdd:cd16944 7 QVLTNILKNAaeaIEGRPSDvgeVRIRVEADQDGRIVLI-VCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIME 85
|
90 100
....*....|....*....|...
gi 446935012 390 TMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16944 86 EHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-412 |
2.41e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 63.25 E-value: 2.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 314 FQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKTK------GTGLGTMVAVKI 387
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 446935012 388 IETMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-399 |
4.42e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 62.09 E-value: 4.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 315 QQCFLNLLKNGIEAMPN--GGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKT--KGTGLGTMVAVKIIET 390
Cdd:cd16976 2 QQVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVEE 81
|
....*....
gi 446935012 391 MQGSLKIRS 399
Cdd:cd16976 82 HGGRLSVAN 90
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
206-412 |
1.27e-11 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 65.49 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 206 QLAA-----SISHEVRNPLTVVKGFTQLLKT----PNLTpesrdEYIKHILEELHHAQGIIDDYLTFAKPASEKLDEI-S 275
Cdd:PRK11073 127 QVAArdlvrGLAHEIKNPLGGLRGAAQLLSKalpdPALT-----EYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIhK 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 276 VEQELNRVINMILPlcnmNTIHITKDF--STATIVGNKQHFQQCFLNLLKNGIEAM-PNGGTLNISSSISNNKVI----- 347
Cdd:PRK11073 202 VAERVVQLVSLELP----DNVRLIRDYdpSLPELAHDPDQIEQVLLNIVRNALQALgPEGGTITLRTRTAFQLTLhgery 277
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 348 -----IRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKgTTLTITFP 412
Cdd:PRK11073 278 rlaarIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-412 |
4.09e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 59.61 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 321 LLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTK-----TKGTGLGTMVAVKIIETMQGSL 395
Cdd:cd16948 13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGHKI 92
|
90
....*....|....*..
gi 446935012 396 KIRSVINKGTTLTITFP 412
Cdd:cd16948 93 DVESEVGEGTTFTITFP 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
180-412 |
2.35e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 62.68 E-value: 2.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 180 YFNE-----VLKDAvcmrSKLIKMEK----M----EIVSQ----LAASISHEVRNPLTVVKGFTQLLKTPNLTPESrdey 242
Cdd:PRK10841 410 YRNEnvaicVLVDV----SARVKMEEslqeMaqaaEQASQsksmFLATVSHELRTPLYGIIGNLDLLQTKELPKGV---- 481
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 243 iKHILEELHHAQG----IIDDYLTFAKPASEKLD----EISVEQELNRVINMILPL---------CnmntiHITKDFSTA 305
Cdd:PRK10841 482 -DRLVTAMNNSSSlllkIISDILDFSKIESEQLKieprEFSPREVINHITANYLPLvvkkrlglyC-----FIEPDVPVA 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 306 tIVGNKQHFQQCFLNLLKNGIEAMPNGGTLnISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKT------KGTGL 379
Cdd:PRK10841 556 -LNGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrnfQGTGL 633
|
250 260 270
....*....|....*....|....*....|...
gi 446935012 380 GTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK10841 634 GLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-412 |
3.98e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 56.83 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 318 FLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYF------STKTKGTGLGTMVAVKIIETM 391
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 446935012 392 QGSLKIRSVINKGTTLTITFP 412
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
318-412 |
4.07e-10 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 58.75 E-value: 4.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 318 FLNLLKN----GIEA--------MPNGGTLNISSSISNNKVIIRIEDSGIG-----------------------MSQEQI 362
Cdd:cd16916 43 LTHLLRNavdhGIEApeerlaagKPPEGTITLRAEHQGNQVVIEVSDDGRGidrekirekaierglitadeaatLSDDEV 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446935012 363 NRF-GEPYFSTKTK-----GTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16916 123 LNLiFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
207-398 |
4.16e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 61.08 E-value: 4.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 207 LAASISHEVRNPLTVVKgftqlLKTPNLTPEsrDEYIKH-ILEELHHAQGIIDDYLTFAKPASEK----------LDE-I 274
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIR-----LATEMMSEE--DGYLAEsINKDIEECNAIIEQFIDYLRTGQEMpmemadlnalLGEvI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 275 SVEQELNRVINMILPLC----NMNTIHItkdfstativgnkqhfQQCFLNLLKNGIEAmpNGGTLNISSSISNNKVIIRI 350
Cdd:PRK09467 305 AAESGYEREIETALQPGpievPMNPIAI----------------KRALANLVVNAARY--GNGWIKVSSGTEGKRAWFQV 366
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 446935012 351 EDSGIGMSQEQINRFGEPYfsTK------TKGTGLGTMVAVKIIETMQGSLKIR 398
Cdd:PRK09467 367 EDDGPGIPPEQLKHLFQPF--TRgdsargSSGTGLGLAIVKRIVDQHNGKVELG 418
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
193-412 |
4.64e-10 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 61.19 E-value: 4.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 193 SKLIKMEKMEivSQLAASISHEVRNPLTVVKGFTQLLK--TPNLTPESrdeyIKHILEELHHAQGIIDDY---------- 260
Cdd:PRK10549 231 STLEKNEQMR--RDFMADISHELRTPLAVLRGELEAIQdgVRKFTPES----VASLQAEVGTLTKLVDDLhqlslsdega 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 261 LTFAKPASE--KLDEISVEQELNRVINmilplcnmNTIHITKDFST-ATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNI 337
Cdd:PRK10549 305 LAYRKTPVDlvPLLEVAGGAFRERFAS--------RGLTLQLSLPDsATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHI 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 338 SSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKTK------GTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITF 411
Cdd:PRK10549 377 SAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
.
gi 446935012 412 P 412
Cdd:PRK10549 457 P 457
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
325-413 |
5.34e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 60.80 E-value: 5.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 325 GIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPyFSTKTKGTGLGTMVAVKIIETMQG---SLKIRSVI 401
Cdd:COG2972 352 GIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEP 430
|
90
....*....|..
gi 446935012 402 NKGTTLTITFPK 413
Cdd:COG2972 431 GEGTTVTIRIPL 442
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-413 |
1.10e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 55.41 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 314 FQQCFLNLLKNGIEAMPngGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYF------STKTKGTGLGTMVAVKI 387
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 446935012 388 IETMQGSLKIRSVINKGTTLTITFPK 413
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
212-412 |
1.40e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.93 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 212 SHEVRNPLTVVKGFTQLLKTPNLtpesrDEYIKHIL----EELHHAQGIIDDyltfakP--ASEKLDEISVEQELNrvIN 285
Cdd:PRK11086 347 SHEFMNKLHVILGLLHLKSYDQL-----EDYILKTAnnyqEEIGSLLGKIKS------PviAGFLLGKISRARELG--IT 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 286 MIL-------PLCNMNTIHITkdfstATIVGNkqhfqqcflnLLKNGIEAMPN--GGTLNISSSISNNKVIIRIEDSGIG 356
Cdd:PRK11086 414 LIIsedsqlpDSGDEDQVHEL-----ITILGN----------LIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPG 478
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 446935012 357 MSQEQINRFGEPYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK11086 479 IAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
209-412 |
1.90e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 59.57 E-value: 1.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 209 ASISHEVRNPLTVVKGFTQLLKTPNLTPESRdEYIKHIleelhHAQG-----IIDDYLTFAKPASEKLdeisveQELNRV 283
Cdd:PRK11091 288 STISHELRTPLNGIVGLSRILLDTELTAEQR-KYLKTI-----HVSAitlgnIFNDIIDMDKMERRKL------QLDNQP 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 284 INMILPLCNMNTIH--------ITKDFST-----ATIVGNKQHFQQCFLNLLKNGIEAMPNGG-TLNISSSIsNNKVIIR 349
Cdd:PRK11091 356 IDFTDFLADLENLSglqaeqkgLRFDLEPllplpHKVITDGTRLRQILWNLISNAVKFTQQGGvTVRVRYEE-GDMLTFE 434
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 350 IEDSGIGMSQEQINRFGEPYFSTKTK-------GTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK11091 435 VEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
206-412 |
2.49e-09 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 58.42 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 206 QLAASISHEVRNPLTVVKGFTQLLK------TPNLTPESRDEYIKHILEELHHAQGIIDDYLTFAKPASEKLDEISVEQE 279
Cdd:PRK09303 153 RVLAMLAHDLRTPLTAASLALETLElgqideDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLD 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 280 LNR----VINMILPLCNMNTIHITKDFST--ATIVGNKQHFQQCFLNLLKNGIEAMPNGGTlnISSSI---SNNKVIIRI 350
Cdd:PRK09303 233 LGSlcqeVILELEKRWLAKSLEIQTDIPSdlPSVYADQERIRQVLLNLLDNAIKYTPEGGT--ITLSMlhrTTQKVQVSI 310
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446935012 351 EDSGIGMSQEQINRFGEPYF----STKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK09303 311 CDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
170-413 |
4.36e-09 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 58.24 E-value: 4.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 170 LPTVLMLFVVYFNEVLkdavcmrsklikmEKMEIV----SQLAASISHEVRNPLTVVKGFTQLLKTPNLTPESRDEYIKH 245
Cdd:PRK09835 237 VPIELEQLVLSFNHMI-------------ERIEDVftrqSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYS 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 246 ILEELHHAQGIIDDYLTFAKPASEKL----DEISVEQELNRVINMILPLCNMNTIHITKDFSTATIVGNKQHFQQCFLNL 321
Cdd:PRK09835 304 NLEELTRMAKMVSDMLFLAQADNNQLipekKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNL 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 322 LKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFST------KTKGTGLGTMVAVKIIETMQGSL 395
Cdd:PRK09835 384 LSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTV 463
|
250
....*....|....*...
gi 446935012 396 KIRSVInKGTTLTITFPK 413
Cdd:PRK09835 464 AVTSDA-RGTRFVISLPR 480
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-400 |
5.43e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 50.54 E-value: 5.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 315 QQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFS-----TKTKGTGLGTMVAVKIIE 389
Cdd:cd16945 6 RQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQ 85
|
90
....*....|.
gi 446935012 390 TMQGSLKIRSV 400
Cdd:cd16945 86 LHGGRITLRNR 96
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-399 |
7.51e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 50.48 E-value: 7.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 315 QQCFLNLLKNGIEAMP-NGGTLNISSSISNNKVI----------IRIEDSGIGMSQEQINRFGEPYFSTKTKGTGLGTMV 383
Cdd:cd16918 2 IQVFLNLVRNAAQALAgSGGEIILRTRTQRQVTLghprhrlalrVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLAI 81
|
90
....*....|....*.
gi 446935012 384 AVKIIETMQGSLKIRS 399
Cdd:cd16918 82 AQNIVSQHGGVIECDS 97
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
211-412 |
7.60e-08 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 54.53 E-value: 7.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 211 ISHEVRNPLTVVKGftqLLktpNLT-PESRDEYIKHILEELH---HAQGIIDDYLTfakpASEKLDEISVEQELNRVINM 286
Cdd:COG3920 302 LHHRVKNNLQVVSS---LL---RLQaRRADDPEAREALEESQnriQALALVHELLY----QSEDWEGVDLRDYLRELLEP 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 287 ILPLCNMNTIHITKDF-------STATIVGnkqhfqqcfL-------NLLKNGIEAMPnGGTLNISSSISNNKVIIRIED 352
Cdd:COG3920 372 LRDSYGGRGIRIELDGpdvelpaDAAVPLG---------LilnelvtNALKHAFLSGE-GGRIRVSWRREDGRLRLTVSD 441
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 353 SGIGMSQEqinrfgepyfSTKTKGTGLGTMVAVKIIETMQGSLKIRSviNKGTTLTITFP 412
Cdd:COG3920 442 NGVGLPED----------VDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFP 489
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
305-412 |
1.17e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 49.59 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 305 ATIVGNkqhfqqcflnLLKNGIEAM----PNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTK-TKGTGL 379
Cdd:cd16915 2 ITIVGN----------LIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKgQGERGI 71
|
90 100 110
....*....|....*....|....*....|...
gi 446935012 380 GTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16915 72 GLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
321-412 |
1.39e-07 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 53.65 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 321 LLKN----GIEaMP-----NG----GTLNISSSISNNKVIIRIEDSGIG-----------------------MSQEQINR 364
Cdd:COG0643 285 LVRNavdhGIE-TPeerlaAGkpetGTITLSAYHEGGRVVIEVSDDGRGldlekirakaiekglitaeeaaaLSDEELLE 363
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446935012 365 F-GEPYFSTKTK-----GTGLGtMVAVK-IIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:COG0643 364 LiFAPGFSTAEEvtdlsGRGVG-MDVVKtNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-412 |
1.66e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 49.25 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 315 QQCFLNLLKNGIEAMPNGGTLNIS--SSISNNKVIIRIEDSGIGMSQEQINR----FGEPYFSTKTKGTGLGTMVAVKII 388
Cdd:cd16921 2 GQVLTNLLGNAIKFRRPRRPPRIEvgAEDVGEEWTFYVRDNGIGIDPEYAEKvfgiFQRLHSREEYEGTGVGLAIVRKII 81
|
90 100
....*....|....*....|....
gi 446935012 389 ETMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16921 82 ERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
309-410 |
3.16e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 49.05 E-value: 3.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 309 GNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKT------KGTGLGTM 382
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDsrnsakQGNGLGLT 95
|
90 100
....*....|....*....|....*...
gi 446935012 383 VAVKIIETMQGSLKIRSVINKGTTLTIT 410
Cdd:cd16947 96 ITKRLAESMGGSIYVNSKPYEKTVFTVT 123
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
213-393 |
1.36e-06 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 50.42 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 213 HEVRNPLTVVKGFTQLLKTPNLTPESRDeyikHILEELHhaQGI------IDDYLTFAKPASEK----LDEISVEQELNR 282
Cdd:PRK10337 246 HELRSPLAALKVQTEVAQLSDDDPQARK----KALLQLH--AGIdratrlVDQLLTLSRLDSLDnlqdVAEIPLEDLLQS 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 283 VINMILPLCNMNTIHITKDFSTATIVGNKQHFQQCFL--NLLKNGIEAMPNGGTLNISSSISNnkviIRIEDSGIGMSQE 360
Cdd:PRK10337 320 AVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLvrNLLDNAIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPE 395
|
170 180 190
....*....|....*....|....*....|....*..
gi 446935012 361 QINRFGEPYF----STKTkGTGLGTMVaVKIIETMQG 393
Cdd:PRK10337 396 ALARIGERFYrppgQEAT-GSGLGLSI-VRRIAKLHG 430
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
199-412 |
1.48e-06 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 50.42 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 199 EKMEIVSQLAASISHEVRNPLTVVKGFTQLLkTPNLTPEsRDEYIKH---ILEELHHAQGIIDDYLTFAKPASE----KL 271
Cdd:PRK10490 659 EREQLRNALLAALSHDLRTPLTVLFGQAEIL-TLDLASE-GSPHARQaseIRQQVLNTTRLVNNLLDMARIQSGgfnlRK 736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 272 DEISVEQELNRVINMILPLCNMNTIHITKDFSTATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIE 351
Cdd:PRK10490 737 EWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVW 816
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446935012 352 DSGIGMSQEQINRFGEPyFSTKTK-----GTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:PRK10490 817 DNGPGIPPGQEQLIFDK-FARGNKesaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
314-412 |
1.55e-06 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 46.72 E-value: 1.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 314 FQQCFLNLLKNGIEAMPNGGTLNISSSISN-NKVIIRIEDSGIG----MSQEQINRF--GEPYFSTKTKGTGLGTMVAVK 386
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGippnLREEIFERFrqGDGSSTRAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|....*.
gi 446935012 387 IIETMQGSLKIRSVINKGTTLTITFP 412
Cdd:cd16925 85 FVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-412 |
1.90e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 46.30 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 320 NLLKNGIEAMPNGGTLNISSSI-SNNKVIIRIEDSGIGMSQEQINRFGEPYFstktKGTGLGTMVAVKIIETMQGS-LKI 397
Cdd:cd16955 12 NAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISPKVIERVEQDEM----PGNKIGLLNVHQRLKLGYGEgLHI 87
|
90
....*....|....*
gi 446935012 398 RSVINKGTTLTITFP 412
Cdd:cd16955 88 RSRPDPGTLIAFYIP 102
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-411 |
2.99e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 45.53 E-value: 2.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 318 FLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYFSTKTKGT-----GLGTMVAVKIIETMQ 392
Cdd:cd16975 9 LINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIAKNLVEKHG 88
|
90
....*....|....*....
gi 446935012 393 GSLKIRSVINKGTTLTITF 411
Cdd:cd16975 89 GSLIIENSQKGGAEVTVKI 107
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
331-412 |
4.12e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 47.69 E-value: 4.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 331 NGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRfgepyfstktKGTGLGTMVavKIIETMQGSLKIRSVINKGTTLTIT 410
Cdd:COG4585 179 GATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPG----------GGLGLRGMR--ERAEALGGTLTIGSAPGGGTRVRAT 246
|
..
gi 446935012 411 FP 412
Cdd:COG4585 247 LP 248
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-398 |
4.60e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 45.13 E-value: 4.60e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446935012 332 GGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYF----STKTKGTGLGTMVAVKIIETMQGSLKIR 398
Cdd:cd16950 17 GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQRISDAHGGSLTLA 87
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-411 |
2.03e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 43.55 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 320 NLLKNGIEAMPNGGTLNISSSiSNNKVIIRIEDSGIGMSQEQINRFGEPYF---STKTKGTGLGTMVAVKIIETMQGSLK 396
Cdd:cd16940 20 NLVDNAVRYSPQGSRVEIKLS-ADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVKRIVELHGGQIF 98
|
90
....*....|....*
gi 446935012 397 IRSVINKGTTLTITF 411
Cdd:cd16940 99 LGNAQGGGLEAWVRL 113
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
332-410 |
6.18e-05 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 42.53 E-value: 6.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 332 GGTLNISSSISNNKVIIRIEDSGIGMsqEQINRFGEPYFSTKT--KGTGLGtmvaVKIIETMQGSLKIRSVINKGTTLTI 409
Cdd:cd16942 60 NGIVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTTKPelERSGMG----FTIMENFMDEVIVESEVNKGTTVYL 133
|
.
gi 446935012 410 T 410
Cdd:cd16942 134 K 134
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-412 |
8.03e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 41.60 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 315 QQCFLNLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYF----STKTKGTGLGTMVAVKIIET 390
Cdd:cd16923 2 QRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIEL 81
|
90 100
....*....|....*....|..
gi 446935012 391 MQGSLKIRSViNKGTTLTITFP 412
Cdd:cd16923 82 HGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
206-418 |
2.06e-04 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 43.03 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 206 QLAASISHEVRNPLTVVKgftqllktpnltpesrdeyiKHIleELHHAQGIIDdyltfAKPASEKLDEI--SVEQ--ELN 281
Cdd:PRK10755 139 LFTADVAHELRTPLAGIR--------------------LHL--ELLEKQHHID-----VAPLIARLDQMmhTVEQllQLA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 282 RVIN---------------MILP----LCNM-----NTIHITKDFSTATIVGNKQHFQQCFLNLLKNGIEAMPNGGTLNI 337
Cdd:PRK10755 192 RAGQsfssghyqtvklledVILPsqdeLSEMleqrqQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITI 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 338 SSSISNNKVIIRIEDSGIGMSQEQINRFGEPY--FSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINK-GTTLTITFPKC 414
Cdd:PRK10755 272 KLSQEDGGAVLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERsGTRAWVWLPKA 351
|
....
gi 446935012 415 NKNS 418
Cdd:PRK10755 352 QNVA 355
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-412 |
3.67e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 40.48 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 332 GGTLNISSSISNNKVIIRIEDSGIGMSQEqinrfgepyFSTKTKGTgLGTMVAVKIIETMQGSLKIRSVINKGTTLTITF 411
Cdd:cd16951 61 GGTITIRSVVDGDYLRITVIDDGVGLPQD---------EDWPNKGS-LGLQIVRSLVEGELKAFLEVQSAENGTRVNIDI 130
|
.
gi 446935012 412 P 412
Cdd:cd16951 131 P 131
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-411 |
5.10e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 39.92 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 289 PLCNM-NTIH------ITKDFS-TATIVGNKQHFQQCFLNLLKN----GIEampnggTLNISSSISNNKVIIRIEDSGIG 356
Cdd:cd16954 5 SLCSAlNKVYqrkgvsISLDISpELRFPGERNDLMELLGNLLDNackwCLE------FVEVTARQTDGGLHLIVDDDGPG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446935012 357 MSQEQINRFGE--PYFSTKTKGTGLGTMVAVKIIETMQGSLKIRSVINKGTTLTITF 411
Cdd:cd16954 79 VPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-412 |
2.42e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 37.43 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 320 NLLKNGIEAMPNGGTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEpyfsTKTKGTGLGtMVAV--KIIETM--QGSL 395
Cdd:cd16924 12 NAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGK----KPKEGNGIG-LYNVhqRLILLFgeDYGI 86
|
90
....*....|....*..
gi 446935012 396 KIRSVINKGTTLTITFP 412
Cdd:cd16924 87 HIASEPDKGTRITFTIP 103
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-412 |
4.73e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 36.64 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446935012 319 LNLLKNGIEAMPNggTLNISSSISNNKVIIRIEDSGIGMSQEQINRFGEPYF------STKTKGTGLGTMVAVKIIETMQ 392
Cdd:cd16939 6 DNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRVALWHG 83
|
90 100
....*....|....*....|
gi 446935012 393 GSLKIRSVINKGTTLTITFP 412
Cdd:cd16939 84 GHVECDDSELGGACFRLTWP 103
|
|
| |
