MULTISPECIES: multidrug effflux MFS transporter [Bacillus]
Protein Classification
multidrug effflux MFS transporter( domain architecture ID 13022939)
multidrug resistance (MDR) MFS transporter is a drug/H+ antiporter (DHA) that mediates the efflux of one or more from a variety of drugs and toxic compounds, and confer resistance to these compounds
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| MFS_MdfA_MDR_like | cd17320 | Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-398 | 1.33e-99 | ||||||
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. : Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 301.80 E-value: 1.33e-99
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| Name | Accession | Description | Interval | E-value | ||||||
| MFS_MdfA_MDR_like | cd17320 | Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-398 | 1.33e-99 | ||||||
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 301.80 E-value: 1.33e-99
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| efflux_Bcr_CflA | TIGR00710 | drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-398 | 1.96e-90 | ||||||
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033. Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 278.50 E-value: 1.96e-90
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| PRK11102 | PRK11102 | Bcr/CflA family multidrug efflux MFS transporter; |
31-404 | 1.37e-77 | ||||||
Bcr/CflA family multidrug efflux MFS transporter; Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 245.21 E-value: 1.37e-77
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| AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-364 | 2.70e-49 | ||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 170.54 E-value: 2.70e-49
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| MFS_1 | pfam07690 | Major Facilitator Superfamily; |
23-366 | 2.10e-29 | ||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 117.13 E-value: 2.10e-29
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| Name | Accession | Description | Interval | E-value | |||||||
| MFS_MdfA_MDR_like | cd17320 | Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-398 | 1.33e-99 | |||||||
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 301.80 E-value: 1.33e-99
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| efflux_Bcr_CflA | TIGR00710 | drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-398 | 1.96e-90 | |||||||
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033. Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 278.50 E-value: 1.96e-90
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| PRK11102 | PRK11102 | Bcr/CflA family multidrug efflux MFS transporter; |
31-404 | 1.37e-77 | |||||||
Bcr/CflA family multidrug efflux MFS transporter; Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 245.21 E-value: 1.37e-77
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| AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-364 | 2.70e-49 | |||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 170.54 E-value: 2.70e-49
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| PRK11043 | PRK11043 | Bcr/CflA family multidrug efflux MFS transporter; |
23-406 | 2.39e-42 | |||||||
Bcr/CflA family multidrug efflux MFS transporter; Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 153.51 E-value: 2.39e-42
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| MFS_MMR_MDR_like | cd17321 | Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-370 | 3.77e-35 | |||||||
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 133.07 E-value: 3.77e-35
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| MFS_YfmO_like | cd17474 | Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-397 | 1.36e-32 | |||||||
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 126.53 E-value: 1.36e-32
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| MFS_MdtG_SLC18_like | cd17325 | bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-387 | 2.73e-31 | |||||||
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 122.68 E-value: 2.73e-31
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| emrD | PRK11652 | multidrug transporter EmrD; |
19-405 | 4.28e-31 | |||||||
multidrug transporter EmrD; Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 122.71 E-value: 4.28e-31
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| MFS_Tpo1_MDR_like | cd17323 | Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
20-197 | 1.72e-30 | |||||||
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 120.76 E-value: 1.72e-30
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| MFS_1 | pfam07690 | Major Facilitator Superfamily; |
23-366 | 2.10e-29 | |||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 117.13 E-value: 2.10e-29
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| MFS_NepI_like | cd17324 | Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
41-386 | 1.15e-28 | |||||||
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 115.34 E-value: 1.15e-28
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| PRK10473 | PRK10473 | MdtL family multidrug efflux MFS transporter; |
31-399 | 1.69e-28 | |||||||
MdtL family multidrug efflux MFS transporter; Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 115.50 E-value: 1.69e-28
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| UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-404 | 1.90e-28 | |||||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 114.58 E-value: 1.90e-28
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| ProP | COG0477 | MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-308 | 1.25e-27 | |||||||
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]; Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 111.06 E-value: 1.25e-27
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| MFS_LmrB_MDR_like | cd17503 | Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
40-371 | 7.24e-26 | |||||||
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 107.66 E-value: 7.24e-26
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| NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-401 | 1.50e-25 | |||||||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.89 E-value: 1.50e-25
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| MFS_arabinose_efflux_permease_like | cd17473 | Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
17-396 | 1.17e-23 | |||||||
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 101.50 E-value: 1.17e-23
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| PRK15402 | PRK15402 | MdfA family multidrug efflux MFS transporter; |
35-401 | 1.23e-23 | |||||||
MdfA family multidrug efflux MFS transporter; Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 101.55 E-value: 1.23e-23
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| MFS_MMR_MDR_like | cd17504 | Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
36-370 | 1.67e-23 | |||||||
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 100.73 E-value: 1.67e-23
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| 2_A_01_02 | TIGR00880 | Multidrug resistance protein; |
63-196 | 8.29e-23 | |||||||
Multidrug resistance protein; Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 93.48 E-value: 8.29e-23
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| FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
13-405 | 1.23e-22 | |||||||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 98.77 E-value: 1.23e-22
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| MFS_Azr1_MDR_like | cd17502 | Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
41-364 | 2.07e-22 | |||||||
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 97.25 E-value: 2.07e-22
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| MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-395 | 1.43e-21 | |||||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.57 E-value: 1.43e-21
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| MFS_MdtH_MDR_like | cd17329 | Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-321 | 6.26e-17 | |||||||
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 81.89 E-value: 6.26e-17
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| efflux_EmrB | TIGR00711 | drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
16-364 | 7.75e-17 | |||||||
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other] Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 82.04 E-value: 7.75e-17
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| MFS_YajR_like | cd17472 | Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
60-307 | 9.25e-16 | |||||||
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 78.03 E-value: 9.25e-16
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| MelB | COG2211 | Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
44-371 | 1.79e-15 | |||||||
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 77.63 E-value: 1.79e-15
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| MFS_SV2_like | cd17316 | Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
45-322 | 3.68e-14 | |||||||
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 73.02 E-value: 3.68e-14
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| MFS_ExuT_GudP_like | cd17319 | Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-398 | 5.27e-14 | |||||||
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.60 E-value: 5.27e-14
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| MFS_SLC46_TetA_like | cd17330 | Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
26-386 | 8.16e-14 | |||||||
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 72.23 E-value: 8.16e-14
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| MFS_YfcJ_like | cd17489 | Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
32-318 | 8.67e-14 | |||||||
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.24 E-value: 8.67e-14
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| MFS_TetA | cd17388 | Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
17-300 | 1.89e-13 | |||||||
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 71.13 E-value: 1.89e-13
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| PRK15403 | PRK15403 | multidrug efflux MFS transporter MdtM; |
32-260 | 1.04e-12 | |||||||
multidrug efflux MFS transporter MdtM; Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 69.08 E-value: 1.04e-12
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| MFS_MefA_like | cd06173 | Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
36-319 | 4.78e-12 | |||||||
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.87 E-value: 4.78e-12
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| 2A0115 | TIGR00895 | benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-197 | 1.91e-11 | |||||||
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 65.07 E-value: 1.91e-11
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| CynX | COG2807 | Cyanate permease [Inorganic ion transport and metabolism]; |
1-397 | 3.31e-11 | |||||||
Cyanate permease [Inorganic ion transport and metabolism]; Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.51 E-value: 3.31e-11
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| MFS_PcaK_like | cd17365 | 4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
41-179 | 1.61e-10 | |||||||
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 62.22 E-value: 1.61e-10
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| MFS_MucK | cd17371 | Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
36-247 | 1.56e-09 | |||||||
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 59.24 E-value: 1.56e-09
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| MFS_XylE_like | cd17359 | D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
41-192 | 3.47e-09 | |||||||
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 57.96 E-value: 3.47e-09
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| MFS_Amf1_MDR_like | cd17476 | Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
41-194 | 5.60e-09 | |||||||
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 57.27 E-value: 5.60e-09
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| 2A0104 | TIGR00881 | phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
68-370 | 7.24e-09 | |||||||
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 57.00 E-value: 7.24e-09
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| MFS_YcxA_like | cd17355 | MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-237 | 1.73e-08 | |||||||
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.13 E-value: 1.73e-08
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| MFS_MJ1317_like | cd17370 | MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
20-393 | 2.08e-08 | |||||||
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 55.63 E-value: 2.08e-08
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| 2A0119 | TIGR00898 | cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
31-127 | 2.16e-08 | |||||||
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 56.18 E-value: 2.16e-08
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| MFS_spinster_like | cd17328 | Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-222 | 2.35e-08 | |||||||
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 55.70 E-value: 2.35e-08
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| MFS_YxlH_like | cd17490 | Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
73-261 | 2.35e-08 | |||||||
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 55.69 E-value: 2.35e-08
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| MFS_MT3072_like | cd17475 | Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
39-387 | 5.74e-08 | |||||||
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.17 E-value: 5.74e-08
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| NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-201 | 7.12e-08 | |||||||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 54.12 E-value: 7.12e-08
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| MFS_TRI12_like | cd06179 | Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
51-187 | 1.21e-07 | |||||||
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.78 E-value: 1.21e-07
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| MFS_FucP_MFSD4_like | cd17333 | Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
39-396 | 3.02e-07 | |||||||
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.94 E-value: 3.02e-07
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| MFS_FsR | cd17478 | Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-395 | 3.06e-07 | |||||||
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 3.06e-07
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| MelB | COG2211 | Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-194 | 3.15e-07 | |||||||
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 3.15e-07
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| Sugar_tr | pfam00083 | Sugar (and other) transporter; |
24-117 | 3.33e-07 | |||||||
Sugar (and other) transporter; Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 52.27 E-value: 3.33e-07
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| PRK03545 | PRK03545 | putative arabinose transporter; Provisional |
82-321 | 3.70e-07 | |||||||
putative arabinose transporter; Provisional Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 51.81 E-value: 3.70e-07
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| MFS_SLC22A18 | cd17331 | Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
48-304 | 3.70e-07 | |||||||
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.84 E-value: 3.70e-07
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| MFS_GLUT_like | cd17315 | Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
52-117 | 5.15e-07 | |||||||
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 51.42 E-value: 5.15e-07
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| MFS_KgtP | cd17367 | Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
68-313 | 5.35e-07 | |||||||
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 51.53 E-value: 5.35e-07
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| MFS_SLC22 | cd17317 | Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-122 | 2.25e-06 | |||||||
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.12 E-value: 2.25e-06
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| MFS_OPA_SLC37 | cd17312 | Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
68-393 | 2.46e-06 | |||||||
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.19 E-value: 2.46e-06
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| MFS_OFA_like | cd17353 | Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-192 | 3.85e-06 | |||||||
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.76 E-value: 3.85e-06
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| MFS_MosC_like | cd17393 | Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
39-393 | 4.03e-06 | |||||||
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 48.41 E-value: 4.03e-06
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| MFS_MJ1317_like | cd17370 | MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
16-187 | 4.42e-06 | |||||||
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 4.42e-06
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| MFS_MFSD9 | cd17390 | Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
32-187 | 5.79e-06 | |||||||
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 47.99 E-value: 5.79e-06
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| MFS_2 | pfam13347 | MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
72-377 | 1.04e-05 | |||||||
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins. Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 47.30 E-value: 1.04e-05
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| MFS_YcaD_like | cd17477 | YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-189 | 1.13e-05 | |||||||
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.17 E-value: 1.13e-05
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| PRK10504 | PRK10504 | putative transporter; Provisional |
74-187 | 1.41e-05 | |||||||
putative transporter; Provisional Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 47.03 E-value: 1.41e-05
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| MFS_Set | cd17471 | Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
57-307 | 2.27e-05 | |||||||
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.27e-05
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| MFS_GLUT6_8_Class3_like | cd17358 | Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
19-120 | 5.30e-05 | |||||||
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 45.26 E-value: 5.30e-05
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| MFS_MFSD10 | cd17389 | Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
73-205 | 5.66e-05 | |||||||
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 44.96 E-value: 5.66e-05
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| MFS_YcaD_like | cd17477 | YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
32-318 | 6.57e-05 | |||||||
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.86 E-value: 6.57e-05
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| MFS_MdtG_MDR_like | cd17391 | Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
74-204 | 7.80e-05 | |||||||
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 7.80e-05
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| MFS_SLC18A1_2_VAT1_2 | cd17384 | Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
72-237 | 1.35e-04 | |||||||
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 43.72 E-value: 1.35e-04
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| MFS_MdtG_MDR_like | cd17391 | Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
17-194 | 1.59e-04 | |||||||
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 1.59e-04
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| MFS_FsR | cd17478 | Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
17-193 | 1.77e-04 | |||||||
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 1.77e-04
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| MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-187 | 1.88e-04 | |||||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 1.88e-04
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| PRK03893 | PRK03893 | putative sialic acid transporter; Provisional |
69-117 | 2.20e-04 | |||||||
putative sialic acid transporter; Provisional Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.15 E-value: 2.20e-04
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| MFS_SLC46 | cd17386 | Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
54-193 | 2.40e-04 | |||||||
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 43.04 E-value: 2.40e-04
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| MFS_HMIT_like | cd17360 | H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
38-117 | 3.08e-04 | |||||||
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 42.64 E-value: 3.08e-04
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| MFS_OAT | cd17374 | Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
44-127 | 4.47e-04 | |||||||
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 41.89 E-value: 4.47e-04
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| MFS_PhT | cd17364 | Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
55-117 | 6.05e-04 | |||||||
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 41.88 E-value: 6.05e-04
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| MFS_SLC22A1_2_3 | cd17379 | Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
64-197 | 7.47e-04 | |||||||
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 41.18 E-value: 7.47e-04
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| PRK09874 | PRK09874 | multidrug efflux MFS transporter MdtG; |
73-200 | 7.58e-04 | |||||||
multidrug efflux MFS transporter MdtG; Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.44 E-value: 7.58e-04
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| MFS_YjiJ | cd06180 | Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
37-397 | 1.11e-03 | |||||||
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.75 E-value: 1.11e-03
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| PRK11551 | PRK11551 | putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
61-117 | 1.57e-03 | |||||||
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.33 E-value: 1.57e-03
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| MFS_SLC22A7_OAT2 | cd17447 | Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
54-126 | 2.41e-03 | |||||||
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 39.71 E-value: 2.41e-03
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| synapt_SV2 | TIGR01299 | synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
64-191 | 2.59e-03 | |||||||
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices. Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.96 E-value: 2.59e-03
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| MFS_SLC22A17 | cd17445 | Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
63-132 | 3.27e-03 | |||||||
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 39.37 E-value: 3.27e-03
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| PRK11646 | PRK11646 | multidrug efflux MFS transporter MdtH; |
56-168 | 3.68e-03 | |||||||
multidrug efflux MFS transporter MdtH; Pssm-ID: 183255 Cd Length: 400 Bit Score: 39.27 E-value: 3.68e-03
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| MFS_SLC22A6_OAT1_like | cd17446 | Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
54-127 | 3.71e-03 | |||||||
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 39.32 E-value: 3.71e-03
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| MFS_GLUT10_12_Class3_like | cd17362 | Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
63-117 | 3.86e-03 | |||||||
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 39.26 E-value: 3.86e-03
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| MFS_HXT | cd17356 | Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
64-117 | 4.41e-03 | |||||||
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.16 E-value: 4.41e-03
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| PRK12307 | PRK12307 | MFS transporter; |
55-187 | 4.88e-03 | |||||||
MFS transporter; Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 39.14 E-value: 4.88e-03
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| BtlA | COG2270 | MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
72-323 | 5.43e-03 | |||||||
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only]; Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 5.43e-03
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| MFS_NRT2_like | cd17341 | Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
39-196 | 5.54e-03 | |||||||
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.77 E-value: 5.54e-03
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| MFS_SLC45_SUC | cd17313 | Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
47-193 | 8.73e-03 | |||||||
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 37.99 E-value: 8.73e-03
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| MFS_SLC18A3_VAChT | cd17383 | Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
70-184 | 9.23e-03 | |||||||
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 38.06 E-value: 9.23e-03
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| MFS_UhpC | cd17488 | Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
40-198 | 9.25e-03 | |||||||
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 38.16 E-value: 9.25e-03
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